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Conserved domains on  [gi|52697494|gb|AAU86484|]
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heat shock protein, partial [Escherichia coli]

Protein Classification

nucleotide exchange factor GrpE( domain architecture ID 1562)

nucleotide exchange factor GrpE functions as a nucleotide exchange factor for DnaK and participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may also function as a thermosensor

CATH:  3.90.20.20|2.30.22.10
Gene Ontology:  GO:0000774|GO:0051087|GO:0006457|GO:0042803
SCOP:  4003783|4002724

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GrpE super family cl03075
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 1-160 3.36e-101

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


The actual alignment was detected with superfamily member PRK10325:

Pssm-ID: 446000 [Multi-domain]  Cd Length: 197  Bit Score: 288.88  E-value: 3.36e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494    1 EEIIMDQHEEIEAVEPEASAEQVDPRDEKIANLEAQLAEAQTRERDGILRVKAEMENLRRRTELDIEKAHKFALEKFINE 80
Cdd:PRK10325  15 EEIIMDQHEEIEAVEPEASAEQVDPRDEKIANLEAQLAEAQTRERDGILRVKAEMENLRRRTELDIEKAHKFALEKFINE 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494   81 LLPVIDSLDRALEVADKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIM 160
Cdd:PRK10325  95 LLPVIDSLDRALEVADKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIM 174
 
Name Accession Description Interval E-value
PRK10325 PRK10325
heat shock protein GrpE; Provisional
 1-160 3.36e-101

heat shock protein GrpE; Provisional


Pssm-ID: 182379 [Multi-domain]  Cd Length: 197  Bit Score: 288.88  E-value: 3.36e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494    1 EEIIMDQHEEIEAVEPEASAEQVDPRDEKIANLEAQLAEAQTRERDGILRVKAEMENLRRRTELDIEKAHKFALEKFINE 80
Cdd:PRK10325  15 EEIIMDQHEEIEAVEPEASAEQVDPRDEKIANLEAQLAEAQTRERDGILRVKAEMENLRRRTELDIEKAHKFALEKFINE 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494   81 LLPVIDSLDRALEVADKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIM 160
Cdd:PRK10325  95 LLPVIDSLDRALEVADKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIM 174
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 31-160 1.01e-42

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 138.75  E-value: 1.01e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494  31 ANLEAQLAEAqtreRDGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSLDRALEVADKaNPDMSAMVEGIE 110
Cdd:COG0576   2 EELEAELAEL----KDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALAAAEE-DEDVKSLLEGVE 76

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 52697494 111 LTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIM 160
Cdd:COG0576  77 MTLKQLLDVLEKHGVEEIEPVGEPFDPNLHEAVSQVPSPDVEPGTVVEVL 126
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 45-160 2.72e-42

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 137.25  E-value: 2.72e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494  45 RDGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSLDRALEVADKaNPDMSAMVEGIELTLKSMLDVVRKFG 124
Cdd:cd00446   4 KDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPK-EEELKNLLEGVEMTLKQLLKVLEKHG 82

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 52697494 125 VEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIM 160
Cdd:cd00446  83 VEEIEPEGEKFDPNLHEAVMQVESPDKEPGTVVEVL 118
GrpE pfam01025
GrpE;
19-160 2.40e-36

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 123.10  E-value: 2.40e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494    19 SAEQVDPRDEKIANLEAQLAEAQTRER---DGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSLDRALEVA 95
Cdd:pfam01025   2 EKKNEEALTDEIESLEEEIEELEKKIEelkEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNSA 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 52697494    96 dKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIM 160
Cdd:pfam01025  82 -PENEDVKSLLEGVEMTLKQLLKILEKHGVEKIEPEGEPFDPNLHEAVSQVPSPEKPEGTVVEVL 145
 
Name Accession Description Interval E-value
PRK10325 PRK10325
heat shock protein GrpE; Provisional
 1-160 3.36e-101

heat shock protein GrpE; Provisional


Pssm-ID: 182379 [Multi-domain]  Cd Length: 197  Bit Score: 288.88  E-value: 3.36e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494    1 EEIIMDQHEEIEAVEPEASAEQVDPRDEKIANLEAQLAEAQTRERDGILRVKAEMENLRRRTELDIEKAHKFALEKFINE 80
Cdd:PRK10325  15 EEIIMDQHEEIEAVEPEASAEQVDPRDEKIANLEAQLAEAQTRERDGILRVKAEMENLRRRTELDIEKAHKFALEKFINE 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494   81 LLPVIDSLDRALEVADKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIM 160
Cdd:PRK10325  95 LLPVIDSLDRALEVADKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIM 174
PRK14150 PRK14150
heat shock protein GrpE; Provisional
 1-160 5.90e-71

heat shock protein GrpE; Provisional


Pssm-ID: 184539 [Multi-domain]  Cd Length: 193  Bit Score: 212.09  E-value: 5.90e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494    1 EEIIMDQHEEIEAVEPEAsAEQVDPRDEKIANLEAQLAEAQTRERDGILRVKAEMENLRRRTELDIEKAHKFALEKFINE 80
Cdd:PRK14150  15 EEIEAEVEQQEEADEAEL-EDELDEADARIAELEAQLAEAQAEERDSVLRARAEVENIRRRAEQDVEKAHKFALEKFANE 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494   81 LLPVIDSLDRALEVADKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIM 160
Cdd:PRK14150  94 LLPVIDNLERALQAADKENEALKALIEGVELTLKSLLDTVAKFGVEVVGPVGEPFNPEVHQAISMQESEDHEPNTVMMVM 173
PRK14151 PRK14151
heat shock protein GrpE; Provisional
 16-157 4.01e-44

heat shock protein GrpE; Provisional


Pssm-ID: 172640 [Multi-domain]  Cd Length: 176  Bit Score: 143.38  E-value: 4.01e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494   16 PEASAEQVDPRDE---KIANLEAQLAEAQtrerDGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSLDRAL 92
Cdd:PRK14151  12 PEAAQAEAAAGDDltaRVQELEEQLAAAK----DQSLRAAADLQNVRRRAEQDVEKAHKFALEKFAGDLLPVVDSLERGL 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 52697494   93 EVADKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVL 157
Cdd:PRK14151  88 ELSSADDEAIKPMREGVELTLKMFQDTLKRYQLEAVDPHGEPFNPEHHQAMAMQESADVEPNSVL 152
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 31-160 1.01e-42

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 138.75  E-value: 1.01e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494  31 ANLEAQLAEAqtreRDGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSLDRALEVADKaNPDMSAMVEGIE 110
Cdd:COG0576   2 EELEAELAEL----KDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALAAAEE-DEDVKSLLEGVE 76

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 52697494 111 LTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIM 160
Cdd:COG0576  77 MTLKQLLDVLEKHGVEEIEPVGEPFDPNLHEAVSQVPSPDVEPGTVVEVL 126
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 45-160 2.72e-42

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 137.25  E-value: 2.72e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494  45 RDGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSLDRALEVADKaNPDMSAMVEGIELTLKSMLDVVRKFG 124
Cdd:cd00446   4 KDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPK-EEELKNLLEGVEMTLKQLLKVLEKHG 82

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 52697494 125 VEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIM 160
Cdd:cd00446  83 VEEIEPEGEKFDPNLHEAVMQVESPDKEPGTVVEVL 118
GrpE pfam01025
GrpE;
19-160 2.40e-36

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 123.10  E-value: 2.40e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494    19 SAEQVDPRDEKIANLEAQLAEAQTRER---DGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSLDRALEVA 95
Cdd:pfam01025   2 EKKNEEALTDEIESLEEEIEELEKKIEelkEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNSA 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 52697494    96 dKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIM 160
Cdd:pfam01025  82 -PENEDVKSLLEGVEMTLKQLLKILEKHGVEKIEPEGEPFDPNLHEAVSQVPSPEKPEGTVVEVL 145
PRK14139 PRK14139
heat shock protein GrpE; Provisional
 6-149 2.55e-33

heat shock protein GrpE; Provisional


Pssm-ID: 237621 [Multi-domain]  Cd Length: 185  Bit Score: 115.84  E-value: 2.55e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494    6 DQHEEIEAVEPEASAEQVDP--RDEKIANLEAQLAEAQTRER---DGILRVKAEMENLRRRTELDIEKAHKFALEKFINE 80
Cdd:PRK14139   8 PSEQEAEEAGAAAQAAAAAAaaAEDAAPALEAELAEAEAKAAelqDSFLRAKAETENVRRRAQEDVAKAHKFAIESFAES 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 52697494   81 LLPVIDSLDRALevADKaNPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESD 149
Cdd:PRK14139  88 LLPVKDSLEAAL--ADE-SGDLEKLREGVELTLKQLTSAFEKGRVVEINPVGEKFDPHQHQAISMVPAE 153
PRK14144 PRK14144
heat shock protein GrpE; Provisional
 6-159 4.44e-31

heat shock protein GrpE; Provisional


Pssm-ID: 184535 [Multi-domain]  Cd Length: 199  Bit Score: 110.97  E-value: 4.44e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494    6 DQHEEIEAVEPEASAEQVDPRDE---------KIANLEAQL--AEAQTRER-DGILRVKAEMENLRRRTELDIEKAHKFA 73
Cdd:PRK14144  14 DEHKEEHKVENEILEEETDEESQhqepalghpSYTALEEQLtlAEQKAHENwEKSVRALAELENVRRRMEREVANAHKYG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494   74 LEKFINELLPVIDSLDRALEVADKANPdmSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAP 153
Cdd:PRK14144  94 VEKLISALLPVVDSLEQALQLADKNSD--PSMHEGLELTMKLFLDALQKFDVEQIDPLGQTFDPQQHEAMSMQPAPGAPP 171


                 ....*.
gi 52697494  154 GNVLGI 159
Cdd:PRK14144 172 NSVITV 177
PRK14140 PRK14140
heat shock protein GrpE; Provisional
 1-156 1.49e-29

heat shock protein GrpE; Provisional


Pssm-ID: 237622 [Multi-domain]  Cd Length: 191  Bit Score: 106.62  E-value: 1.49e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494    1 EEIIMDQHEEiEAVEPEASAEQVDPRDEKIANLEAQLAEAQTRErdgiLRVKAEMENLRRRTELDIEKAHKFALEKFINE 80
Cdd:PRK14140  18 EEAVEDEVEE-ETVEEESEAELLDEEQAKIAELEAKLDELEERY----LRLQADFENYKRRIQKENEAAEKYRAQSLASD 92

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 52697494   81 LLPVIDSLDRALEVADKaNPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNV 156
Cdd:PRK14140  93 LLPALDNFERALQIEAD-DEQTKSLLKGVEMVHRQLLEALKKEGVEVIEAVGEQFDPNLHQAVMQDEDEDFESNEV 167
PRK14147 PRK14147
heat shock protein GrpE; Provisional
 5-159 5.69e-27

heat shock protein GrpE; Provisional


Pssm-ID: 237625 [Multi-domain]  Cd Length: 172  Bit Score: 99.25  E-value: 5.69e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494    5 MDQ-HEEIEAVEPEASAEQVDPRDEKIANLEAQLAEAQTrerdGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLP 83
Cdd:PRK14147   1 MNQdHPEFDSEDLAQNPPETDPLKAEVESLRSEIALVKA----DALRERADLENQRKRIARDVEQARKFANEKLLGELLP 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 52697494   84 VIDSLDRALEVadkANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGI 159
Cdd:PRK14147  77 VFDSLDAGLTA---AGTEPSPLRDGLELTYKQLLKVAADNGLTLLDPVGQPFNPEHHQAISQGEAEGVAPGHVVQV 149
PRK14158 PRK14158
heat shock protein GrpE; Provisional
 1-159 7.08e-27

heat shock protein GrpE; Provisional


Pssm-ID: 172646 [Multi-domain]  Cd Length: 194  Bit Score: 99.62  E-value: 7.08e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494    1 EEIIMDQHEEIEAVEPEASAEQVDPRDEKIANLEAQLA--EAQTRER-DGILRVKAEMENLRRRTELDIEKAHKFALEKF 77
Cdd:PRK14158  13 EALKAKAAKEAEAAQGKPEAAQPVAAADRIKELEEALAakEAEAAANwDKYLRERADLENYRKRVQKEKEELLKYGNESL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494   78 INELLPVIDSLDRALEVADKANpdMSAMVEGIELTLKSMLDVVRKFGVEVI-AETNVPLDPNVHQAIAMVESDDVAPGNV 156
Cdd:PRK14158  93 ILEILPAVDNMERALDHADEES--MSAIIEGIRMTLSMLLSTLKKFGVTPVeAEKGTPFDPAYHQAMCQVESAEQEPNTV 170


                 ...
gi 52697494  157 LGI 159
Cdd:PRK14158 171 VAV 173
PRK14141 PRK14141
heat shock protein GrpE; Provisional
 15-156 4.53e-24

heat shock protein GrpE; Provisional


Pssm-ID: 172630  Cd Length: 209  Bit Score: 92.81  E-value: 4.53e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494   15 EPEASAEQVDPRDEKIANLEAQLAEAqtreRDGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSLDRAL-- 92
Cdd:PRK14141  25 EAKPYEMEDDPEPDPLEALKAENAEL----KDRMLRLAAEMENLRKRTQRDVADARAYGIAGFARDMLSVSDNLRRALda 100

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 52697494   93 ---EVADKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNV 156
Cdd:PRK14141 101 ipaEARAAADAGLKALIEGVEMTERAMLNALERHGVKKLDPEGQKFDPNFHQAMFEVPNPDVPNNTV 167
PRK14148 PRK14148
heat shock protein GrpE; Provisional
 5-146 2.00e-23

heat shock protein GrpE; Provisional


Pssm-ID: 172637 [Multi-domain]  Cd Length: 195  Bit Score: 90.97  E-value: 2.00e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494    5 MDQHEEIEAVEPEASAEQVDPRDEKIANLEaqlaEAQTRERDGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPV 84
Cdd:PRK14148  24 TAQESASGALEELSVEEQLERAKDTIKELE----DSCDQFKDEALRAKAEMENIRKRAERDVSNARKFGIEKFAKELLPV 99

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 52697494   85 IDSLDRALEVADKANPDMsAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMV 146
Cdd:PRK14148 100 IDSIEQALKHEVKLEEAI-AMKEGIELTAKMLVDILKKNGVEELDPKGEKFDPNLHEAMAMI 160
PRK14155 PRK14155
heat shock protein GrpE; Provisional
 12-160 1.22e-20

heat shock protein GrpE; Provisional


Pssm-ID: 237627 [Multi-domain]  Cd Length: 208  Bit Score: 83.86  E-value: 1.22e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494   12 EAVEPEASAEQVDPRDEKIANLEAQLAEAqtreRDGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSLDRA 91
Cdd:PRK14155   4 EQTPAEDGPFEADDAAQEIEALKAEVAAL----KDQALRYAAEAENTKRRAEREMNDARAYAIQKFARDLLGAADNLGRA 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 52697494   92 LEVA--DKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAET-NVPLDPNVHQAIAMVESDDVAPGNVLGIM 160
Cdd:PRK14155  80 TAASpkDSADPAVKNFIIGVEMTEKELLGAFERNGLKKIDPAkGDKFDPHLHQAMMEQPSTEVAAGGVLQVM 151
PRK14149 PRK14149
heat shock protein GrpE; Provisional
 9-160 5.63e-20

heat shock protein GrpE; Provisional


Pssm-ID: 184538 [Multi-domain]  Cd Length: 191  Bit Score: 81.84  E-value: 5.63e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494    9 EEIEAVEPEASAEQVDPRDEKIANLEAQLAEAqtreRDGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSL 88
Cdd:PRK14149  24 CACKEQQGEEKQEASEKEGEIKEDFELKYKEM----HEKYLRVHADFENVKKRLERDKSMALEYAYEKIALDLLPVIDAL 99

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 52697494   89 DRALEVAdKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIaETNVPLDPNVHQAIAMVESDDVAPGNVLGIM 160
Cdd:PRK14149 100 LGALKSA-AEVDKESALTKGLELTMEKLHEVLARHGIEGI-ECLEEFDPNFHNAIMQVKSEEKENGKIVQVL 169
PRK14153 PRK14153
heat shock protein GrpE; Provisional
 1-152 1.38e-17

heat shock protein GrpE; Provisional


Pssm-ID: 184540 [Multi-domain]  Cd Length: 194  Bit Score: 75.65  E-value: 1.38e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494    1 EEIIMDQHEEIEAVEPEASAEQVDPRDEKIANLEAQLAEAQTRE-----RDGILRVKAEMENLRRRTELDIEKAHKFALE 75
Cdd:PRK14153   4 KEVGKDKAENSEARNSGSSAEEAEELKEEPEDSTADSETEKCREeieslKEQLFRLAAEFDNFRKRTAREMEENRKFVLE 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 52697494   76 KFINELLPVIDSLDRALEVADKANpDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVA 152
Cdd:PRK14153  84 QVLLDLLEVTDNFERALESARTAE-DMNSIVEGIEMVSKQFFSILEKYGLERIECEGEEFDPHRHEAMMHVETSEVP 159
PRK14154 PRK14154
heat shock protein GrpE; Provisional
 2-160 4.28e-17

heat shock protein GrpE; Provisional


Pssm-ID: 237626 [Multi-domain]  Cd Length: 208  Bit Score: 74.85  E-value: 4.28e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494    2 EIIMDQHEEIEAVEPEASAEQVDPRD----EKIANLEAQLAEAQTR---ERDGILRVKAEMENLRRRTELDIEKAHKFAL 74
Cdd:PRK14154  22 EKVMEAEEEQEEGGGDGSQEMEPHREglefPSREKLEGQLTRMERKvdeYKTQYLRAQAEMDNLRKRIEREKADIIKFGS 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494   75 EKFINELLPVIDSLDRALEVADKANPDMSAMVEGIELTLKSMLDVVRKFGVEVI-AETNVPLDPNVHQAIAMVESDDVAP 153
Cdd:PRK14154 102 KQLITDLLPVADSLIHGLESPASEDPQVKSMRDGMSLTLDLLHNTLAKHGVQVInPNPGDPFDPALHEAMSVQAVPDAKP 181


                 ....*..
gi 52697494  154 GNVLGIM 160
Cdd:PRK14154 182 DTIIQVL 188
PRK14159 PRK14159
heat shock protein GrpE; Provisional
 6-160 3.24e-14

heat shock protein GrpE; Provisional


Pssm-ID: 172647 [Multi-domain]  Cd Length: 176  Bit Score: 66.25  E-value: 3.24e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494    6 DQHEEIEAVEPEASAEQVDPRDEKIANLEAQLAEAQTRE-RDGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPV 84
Cdd:PRK14159   3 EQKQEFENENAENSEHLQDENLQNIEDVEQNKLQKDYDElKDKYMRANAEFENIKKRMEKEKLSAMAYANESFAKDLLDV 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 52697494   85 IDSLDRALEVadKANPDMSAMV-EGIELTLKSMLDVVRKFGVEVIAETNvPLDPNVHQAIAMVESDDVAPGNVLGIM 160
Cdd:PRK14159  83 LDALEAAVNV--ECHDEISLKIkEGVQNTLDLFLKKLEKHGVALIKEEK-EFDPNLHEAMFHVDSENHQSGEVVQVL 156
PRK14163 PRK14163
heat shock protein GrpE; Provisional
 12-160 9.02e-14

heat shock protein GrpE; Provisional


Pssm-ID: 184546 [Multi-domain]  Cd Length: 214  Bit Score: 65.92  E-value: 9.02e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494   12 EAVEPEASAEQ-VDPRDEKIAN--LEAQLAEAQTR--ERDGIL-RVKAEMENLRRRTELDIEKAHKFALEKFINELLPVI 85
Cdd:PRK14163  21 DDAEPKAASEEgAAPAGDAAATagLTAQLDQVRTAlgERTADLqRLQAEYQNYRRRVERDRVTVKEIAVANLLSELLPVL 100

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 52697494   86 DSLDRALEVADkanpdmsaMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIM 160
Cdd:PRK14163 101 DDVGRAREHGE--------LVGGFKSVAESLETTVAKLGLQQFGKEGEPFDPTIHEALMHSYAPDVTETTCVAIL 167
PRK14162 PRK14162
heat shock protein GrpE; Provisional
 13-150 1.90e-13

heat shock protein GrpE; Provisional


Pssm-ID: 237631 [Multi-domain]  Cd Length: 194  Bit Score: 64.86  E-value: 1.90e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494   13 AVEPEASAEQVDPRDEKIANLEAQLAEAQTRER---DGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSLD 89
Cdd:PRK14162  24 KEAKEAPKEEDQEKQNPVEDLEKEIADLKAKNKdleDKYLRSQAEIQNMQNRYAKERAQLIKYESQSLAKDVLPAMDNLE 103

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 52697494   90 RALEVadKANPDMSAMVE-GIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDD 150
Cdd:PRK14162 104 RALAV--KADDEAAKQLKkGVQMTLDHLVKALKDHGVTEIKADGEKFDPTLHQAVQTVAAEN 163
PRK14145 PRK14145
heat shock protein GrpE; Provisional
 9-157 3.12e-13

heat shock protein GrpE; Provisional


Pssm-ID: 184536 [Multi-domain]  Cd Length: 196  Bit Score: 64.17  E-value: 3.12e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494    9 EEIEAVEPEASAEQVDPRDEKIANLEAQLAEAQtRERDGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSL 88
Cdd:PRK14145  30 EDEQAQQNQPQQQTVDEIEELKQKLQQKEVEAQ-EYLDIAQRLKAEFENYRKRTEKEKSEMVEYGKEQVILELLPVMDNF 108

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 52697494   89 DRALEvadkANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVL 157
Cdd:PRK14145 109 ERALA----SSGDYNSLKEGIELIYRQFKKILDKFGVKEIEAEGQIFDPYKHHAVMQEEVEGKQPNEII 173
PRK14161 PRK14161
heat shock protein GrpE; Provisional
 6-160 6.51e-13

heat shock protein GrpE; Provisional


Pssm-ID: 237630 [Multi-domain]  Cd Length: 178  Bit Score: 63.07  E-value: 6.51e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494    6 DQHEEIEAVEPEASAEQVDPRDEKIANLEAQLAEAQtrerDGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVI 85
Cdd:PRK14161   4 DNIENNEQTINDIAEEIVETANPEITALKAEIEELK----DKLIRTTAEIDNTRKRLEKARDEAKDYAIATFAKELLNVS 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 52697494   86 DSLDRALE-VADKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIA-ETNVPLDPNVHQAIAMVESDDVAPGNVLGIM 160
Cdd:PRK14161  80 DNLSRALAhKPANSDVEVTNIIAGVQMTKDELDKVFHKHHIEEIKpEIGSMFDYNLHNAISQIEHPDHAPNSIITLM 156
PRK14146 PRK14146
heat shock protein GrpE; Provisional
 7-157 1.80e-12

heat shock protein GrpE; Provisional


Pssm-ID: 172635 [Multi-domain]  Cd Length: 215  Bit Score: 62.44  E-value: 1.80e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494    7 QHEEIEAVEPEASAEQVDPRDEKIAnLEAQLAEAQTR---ERDGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLP 83
Cdd:PRK14146  34 NSEESQTITEETQEQAVEGAETETS-LQKELDNAKKEiesLKDSWARERAEFQNFKRRSAQEFVSIRKEAVKSLVSGFLN 112

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 52697494   84 VIDSLDRALEVADKAnPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVL 157
Cdd:PRK14146 113 PIDNLERVGATQNQS-EELKPFVEGVKMILKEFYSVLEKSNVIRFDPKGEPFDPMSMEALSSEEGDQYSEETVI 185
PRK14160 PRK14160
heat shock protein GrpE; Provisional
 1-156 3.31e-12

heat shock protein GrpE; Provisional


Pssm-ID: 237629 [Multi-domain]  Cd Length: 211  Bit Score: 61.69  E-value: 3.31e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494    1 EEIIMDQHEEIEAVEPEASAEQVDPRDEKiANLEAQLAEAQTRerdgILRVKAEMENLRRRTELDIEKAHKFALEKFINE 80
Cdd:PRK14160  42 EEIIEDSEESNEVKIEELKDENNKLKEEN-KKLENELEALKDR----LLRTVAEYDNYRKRTAKEKEGIYSDACEDVLKE 116

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 52697494   81 LLPVIDSLDRALEVadkaNPDMSAMVEGIELTLKSMLDVVRKFGVEVIaETNVPLDPNVHQAIAMVESDDVAPGNV 156
Cdd:PRK14160 117 LLPVLDNLERAAAV----EGSVEDLKKGIEMTVKQFKTSLEKLGVEEI-STEGEFDPNLHNAVMHVEDENYGENEI 187
PRK14143 PRK14143
heat shock protein GrpE; Provisional
 10-157 4.25e-11

heat shock protein GrpE; Provisional


Pssm-ID: 237624 [Multi-domain]  Cd Length: 238  Bit Score: 58.97  E-value: 4.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494   10 EIEAVEPEASAEQVDPRDEKIANLEAQLAEAQTR----------ERDGILRVKAEMENLRRRTELDIEKAHKFALEKFIN 79
Cdd:PRK14143  42 EGDAAEAESSPDSGSAASETAADNAARLAQLEQEleslkqeleeLNSQYMRIAADFDNFRKRTSREQEDLRLQLKCNTLS 121

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 52697494   80 ELLPVIDSLDRALEVADKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVL 157
Cdd:PRK14143 122 EILPVVDNFERARQQLKPEGEEAQALHRSYQGLYKQLVDVLKRLGVSPMRVVGQEFDPNLHEAVLREPSDEHPEDVVL 199
PRK14164 PRK14164
heat shock protein GrpE; Provisional
 1-157 4.25e-10

heat shock protein GrpE; Provisional


Pssm-ID: 237632 [Multi-domain]  Cd Length: 218  Bit Score: 55.96  E-value: 4.25e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494    1 EEIIMDQHEEIEAVEPEASAEQVDPRDEkiANLEAQLAEaqtRERDgILRVKAEMENLRRRTELDIEKAHKFALEKFINE 80
Cdd:PRK14164  52 GEIDPDLEADLEDLLDDVDPELADDGEA--STVEAQLAE---RTED-LQRVTAEYANYRRRTERERQAIIETAKAGVATD 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494   81 LLPVIDSLDRALEVADkanpdmsaMVEGielTLKSMLD----VVRKFGVEVIAETNVPLDPNVHQAIA-MVESDDVAPGN 155
Cdd:PRK14164 126 LLPILDDLDLAEQHGD--------LNEG---PLKAFSDkltnVLAGLKVEKFGEEGDAFDPEIHEAVQdLSSGDEKVLGT 194


                 ..
gi 52697494  156 VL 157
Cdd:PRK14164 195 VL 196
PRK14156 PRK14156
heat shock protein GrpE; Provisional
 9-153 2.02e-09

heat shock protein GrpE; Provisional


Pssm-ID: 237628 [Multi-domain]  Cd Length: 177  Bit Score: 53.68  E-value: 2.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494    9 EEIEAVEPEASAEQVDPRDEKIANLEAQLAEAQTRErDGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSL 88
Cdd:PRK14156  12 EEVEATETEETVEEVVEETPEKSELELANERADEFE-NKYLRAHAEMQNIQRRANEERQQLQRYRSQDLAKAILPSLDNL 90

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 52697494   89 DRALEVADKANPdmsaMVEGIELTLKSMLDVVRKFGVEVIAETNvpLDPNVHQAIAMVESDDVAP 153
Cdd:PRK14156  91 ERALAVEGLTDD----VKKGLEMVQESLIQALKEEGVEEVAVDS--FDHNLHMAVQTLPADDEHP 149
PRK14157 PRK14157
heat shock protein GrpE; Provisional
 9-143 1.39e-04

heat shock protein GrpE; Provisional


Pssm-ID: 184543 [Multi-domain]  Cd Length: 227  Bit Score: 40.71  E-value: 1.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494    9 EEIEAVEPEASAEQVDPRDEKIANL------EAQLAEAQTRERdgilrvkAEMENLRRRTELDIEKAHKFALEKFINELL 82
Cdd:PRK14157  62 EGEAKAAAEKTGEAQSDSDDTLTPLgqakkeAAEYLEALQRER-------AEFINYRNRTQKEQDRFRQHGIIDVLTALL 134

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 52697494   83 PVIDSLDRALEvadkanpdMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAI 143
Cdd:PRK14157 135 PALDDIDRIRE--------HSEMDDSFKAVAAKIDKAFEKFGVEKFGEKGEDFDPTKHDAI 187
PRK14142 PRK14142
heat shock protein GrpE; Provisional
 26-143 4.88e-04

heat shock protein GrpE; Provisional


Pssm-ID: 237623  Cd Length: 223  Bit Score: 38.83  E-value: 4.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697494   26 RDEKIANLEAQLAeaqtrerdgilRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSLDRALEVADKANPDMSAM 105
Cdd:PRK14142  45 TEDKVAELTADLQ-----------RVQADFANYRKRALRDQQAAADRAKASVVSQLLGVLDDLERARKHGDLESGPLKSV 113

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 52697494  106 VEGIELTLKSMLDVVrkFGVEviaetNVPLDPNVHQAI 143
Cdd:PRK14142 114 ADKLDSALTGLGLVA--FGAE-----GEDFDPVLHEAV 144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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