NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|52697056|gb|AAU86265|]
View 

clp protease ATP-binding subunit, partial [Escherichia albertii]

Protein Classification

ATP-dependent Clp protease ATP-binding subunit ClpX( domain architecture ID 1021634)

ATP-dependent Clp protease ATP-binding subunit ClpX is an ATP-dependent specificity component of the Clp protease that uses cycles of ATP-binding and hydrolysis to unfold proteins and translocate them to the ClpP protease

CATH:  1.10.8.60
Gene Ontology:  GO:0005524|GO:0016887|GO:0006457
SCOP:  4000283

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ClpX super family cl34188
ATP-dependent protease Clp, ATPase subunit ClpX [Posttranslational modification, protein ...
 1-204 8.25e-168

ATP-dependent protease Clp, ATPase subunit ClpX [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG1219:

Pssm-ID: 440832 [Multi-domain]  Cd Length: 409  Bit Score: 467.22  E-value: 8.25e-168
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056   1 HYKRLRNGDTS-NGVELGKSNILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTEAGYVGEDVENIIQKLLQKCDYDV 79
Cdd:COG1219  91 HYKRLNSGSKDdDDVELEKSNILLIGPTGSGKTLLAQTLARILDVPFAIADATTLTEAGYVGEDVENILLKLLQAADYDV 170

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056  80 QKAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTVAAVPPQGGRKHPQQEFLQVDTSKILFICGGAFAG 159
Cdd:COG1219 171 EKAERGIIYIDEIDKIARKSENPSITRDVSGEGVQQALLKILEGTVANVPPQGGRKHPQQEFIQIDTTNILFICGGAFDG 250

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 52697056 160 LDKVISHRVETgSGIGFGATVKAKSDKaSEGELLAQVEPEDLIKF 204
Cdd:COG1219 251 LEKIIERRLGK-KSIGFGAEVKSKKEK-DEGELLKQVEPEDLIKF 293
 
Name Accession Description Interval E-value
ClpX COG1219
ATP-dependent protease Clp, ATPase subunit ClpX [Posttranslational modification, protein ...
 1-204 8.25e-168

ATP-dependent protease Clp, ATPase subunit ClpX [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440832 [Multi-domain]  Cd Length: 409  Bit Score: 467.22  E-value: 8.25e-168
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056   1 HYKRLRNGDTS-NGVELGKSNILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTEAGYVGEDVENIIQKLLQKCDYDV 79
Cdd:COG1219  91 HYKRLNSGSKDdDDVELEKSNILLIGPTGSGKTLLAQTLARILDVPFAIADATTLTEAGYVGEDVENILLKLLQAADYDV 170

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056  80 QKAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTVAAVPPQGGRKHPQQEFLQVDTSKILFICGGAFAG 159
Cdd:COG1219 171 EKAERGIIYIDEIDKIARKSENPSITRDVSGEGVQQALLKILEGTVANVPPQGGRKHPQQEFIQIDTTNILFICGGAFDG 250

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 52697056 160 LDKVISHRVETgSGIGFGATVKAKSDKaSEGELLAQVEPEDLIKF 204
Cdd:COG1219 251 LEKIIERRLGK-KSIGFGAEVKSKKEK-DEGELLKQVEPEDLIKF 293
clpX PRK05342
ATP-dependent Clp protease ATP-binding subunit ClpX;
1-204 2.54e-164

ATP-dependent Clp protease ATP-binding subunit ClpX;


Pssm-ID: 235422 [Multi-domain]  Cd Length: 412  Bit Score: 458.47  E-value: 2.54e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056    1 HYKRLRNG-DTSNGVELGKSNILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTEAGYVGEDVENIIQKLLQKCDYDV 79
Cdd:PRK05342  90 HYKRLRHGdKKDDDVELQKSNILLIGPTGSGKTLLAQTLARILDVPFAIADATTLTEAGYVGEDVENILLKLLQAADYDV 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056   80 QKAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTVAAVPPQGGRKHPQQEFLQVDTSKILFICGGAFAG 159
Cdd:PRK05342 170 EKAQRGIVYIDEIDKIARKSENPSITRDVSGEGVQQALLKILEGTVASVPPQGGRKHPQQEFIQVDTTNILFICGGAFDG 249

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 52697056  160 LDKVISHRVEtGSGIGFGATVKAKSDKASEGELLAQVEPEDLIKF 204
Cdd:PRK05342 250 LEKIIKQRLG-KKGIGFGAEVKSKKEKRTEGELLKQVEPEDLIKF 293
RecA-like_ClpX cd19497
ATP-dependent Clp protease ATP-binding subunit ClpX; ClpX is a component of the ATP-dependent ...
 1-204 2.09e-139

ATP-dependent Clp protease ATP-binding subunit ClpX; ClpX is a component of the ATP-dependent protease ClpXP. In ClpXP, ClpX ATPase serves to specifically recognize, unfold, and translocate protein substrates into the chamber of ClpP protease for degradation. This RecA-like_ClpX domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410905 [Multi-domain]  Cd Length: 251  Bit Score: 389.27  E-value: 2.09e-139
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056   1 HYKRLRNG--DTSNGVELGKSNILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTEAGYVGEDVENIIQKLLQKCDYD 78
Cdd:cd19497  31 HYKRIRNNlkQKDDDVELEKSNILLIGPTGSGKTLLAQTLAKILDVPFAIADATTLTEAGYVGEDVENILLKLLQAADYD 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056  79 VQKAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTVAAVPPQGGRKHPQQEFLQVDTSKILFICGGAFA 158
Cdd:cd19497 111 VERAQRGIVYIDEIDKIARKSENPSITRDVSGEGVQQALLKILEGTVANVPPQGGRKHPQQEFIQVDTTNILFICGGAFV 190

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 52697056 159 GLDKVISHRVETGSgIGFGATVKAKSDKASEGELLAQVEPEDLIKF 204
Cdd:cd19497 191 GLEKIIARRLGKKS-LGFGAETSSEKDEKERDELLSKVEPEDLIKF 235
clpX TIGR00382
endopeptidase Clp ATP-binding regulatory subunit (clpX); A member of the ATP-dependent ...
 1-204 4.72e-132

endopeptidase Clp ATP-binding regulatory subunit (clpX); A member of the ATP-dependent proteases, ClpX has ATP-dependent chaperone activity and is required for specific ATP-dependent proteolytic activities expressed by ClpPX. The gene is also found to be involved in stress tolerance in Bacillus subtilis and is essential for the efficient acquisition of genes specifying type IA and IB restriction. [Protein fate, Protein folding and stabilization, Protein fate, Degradation of proteins, peptides, and glycopeptides]


Pssm-ID: 273047 [Multi-domain]  Cd Length: 413  Bit Score: 376.80  E-value: 4.72e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056     1 HYKRLR---NGDTSNGVELGKSNILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTEAGYVGEDVENIIQKLLQKCDY 77
Cdd:TIGR00382  96 HYKRLNfekNKKSDNGVELSKSNILLIGPTGSGKTLLAQTLARILNVPFAIADATTLTEAGYVGEDVENILLKLLQAADY 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056    78 DVQKAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTVAAVPPQGGRKHPQQEFLQVDTSKILFICGGAF 157
Cdd:TIGR00382 176 DVEKAQKGIIYIDEIDKISRKSENPSITRDVSGEGVQQALLKIIEGTVANVPPQGGRKHPYQEFIQIDTSNILFICGGAF 255

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 52697056   158 AGLDKVISHRVETGSgIGFGATVKAKSDKasEGELLAQVEPEDLIKF 204
Cdd:TIGR00382 256 VGLEKIIKKRTGKSS-IGFGAEVKKKSKE--KADLLRQVEPEDLVKF 299
AAA_2 pfam07724
AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected ...
 18-204 3.34e-32

AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400187 [Multi-domain]  Cd Length: 168  Bit Score: 114.21  E-value: 3.34e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056    18 KSNILLIGPTGSGKTLLAETLARLLDV---PFTMADATTLTEagyvgedvENIIQKLLQKCDYDVQKAQRG--------- 85
Cdd:pfam07724   3 IGSFLFLGPTGVGKTELAKALAELLFGderALIRIDMSEYME--------EHSVSRLIGAPPGYVGYEEGGqlteavrrk 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056    86 ---IVYIDEIDKISRksdnpsitrdvsgeGVQQALLKLIEGTVaaVPPQGGRkhpqqeflQVDTSKILFICGGAFAGLDK 162
Cdd:pfam07724  75 pysIVLIDEIEKAHP--------------GVQNDLLQILEGGT--LTDKQGR--------TVDFKNTLFIMTGNFGSEKI 130

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 52697056   163 VIshrvetgsgigfgatvkAKSDKASEGELLAQVEPEDLIKF 204
Cdd:pfam07724 131 SD-----------------ASRLGDSPDYELLKEEVMDLLKK 155
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 18-98 1.17e-06

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 46.60  E-value: 1.17e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056     18 KSNILLIGPTGSGKTLLAETLARLLDVP---FTMADATTLTEAGYVGEDVENIIQKLLQKCDYD--------VQKAQRGI 86
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPPgggVIYIDGEDILEEVLDQLLLIIVGGKKASGSGELrlrlalalARKLKPDV 81

                           90
                   ....*....|..
gi 52697056     87 VYIDEIDKISRK 98
Cdd:smart00382  82 LILDEITSLLDA 93
 
Name Accession Description Interval E-value
ClpX COG1219
ATP-dependent protease Clp, ATPase subunit ClpX [Posttranslational modification, protein ...
 1-204 8.25e-168

ATP-dependent protease Clp, ATPase subunit ClpX [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440832 [Multi-domain]  Cd Length: 409  Bit Score: 467.22  E-value: 8.25e-168
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056   1 HYKRLRNGDTS-NGVELGKSNILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTEAGYVGEDVENIIQKLLQKCDYDV 79
Cdd:COG1219  91 HYKRLNSGSKDdDDVELEKSNILLIGPTGSGKTLLAQTLARILDVPFAIADATTLTEAGYVGEDVENILLKLLQAADYDV 170

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056  80 QKAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTVAAVPPQGGRKHPQQEFLQVDTSKILFICGGAFAG 159
Cdd:COG1219 171 EKAERGIIYIDEIDKIARKSENPSITRDVSGEGVQQALLKILEGTVANVPPQGGRKHPQQEFIQIDTTNILFICGGAFDG 250

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 52697056 160 LDKVISHRVETgSGIGFGATVKAKSDKaSEGELLAQVEPEDLIKF 204
Cdd:COG1219 251 LEKIIERRLGK-KSIGFGAEVKSKKEK-DEGELLKQVEPEDLIKF 293
clpX PRK05342
ATP-dependent Clp protease ATP-binding subunit ClpX;
1-204 2.54e-164

ATP-dependent Clp protease ATP-binding subunit ClpX;


Pssm-ID: 235422 [Multi-domain]  Cd Length: 412  Bit Score: 458.47  E-value: 2.54e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056    1 HYKRLRNG-DTSNGVELGKSNILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTEAGYVGEDVENIIQKLLQKCDYDV 79
Cdd:PRK05342  90 HYKRLRHGdKKDDDVELQKSNILLIGPTGSGKTLLAQTLARILDVPFAIADATTLTEAGYVGEDVENILLKLLQAADYDV 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056   80 QKAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTVAAVPPQGGRKHPQQEFLQVDTSKILFICGGAFAG 159
Cdd:PRK05342 170 EKAQRGIVYIDEIDKIARKSENPSITRDVSGEGVQQALLKILEGTVASVPPQGGRKHPQQEFIQVDTTNILFICGGAFDG 249

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 52697056  160 LDKVISHRVEtGSGIGFGATVKAKSDKASEGELLAQVEPEDLIKF 204
Cdd:PRK05342 250 LEKIIKQRLG-KKGIGFGAEVKSKKEKRTEGELLKQVEPEDLIKF 293
RecA-like_ClpX cd19497
ATP-dependent Clp protease ATP-binding subunit ClpX; ClpX is a component of the ATP-dependent ...
 1-204 2.09e-139

ATP-dependent Clp protease ATP-binding subunit ClpX; ClpX is a component of the ATP-dependent protease ClpXP. In ClpXP, ClpX ATPase serves to specifically recognize, unfold, and translocate protein substrates into the chamber of ClpP protease for degradation. This RecA-like_ClpX domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410905 [Multi-domain]  Cd Length: 251  Bit Score: 389.27  E-value: 2.09e-139
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056   1 HYKRLRNG--DTSNGVELGKSNILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTEAGYVGEDVENIIQKLLQKCDYD 78
Cdd:cd19497  31 HYKRIRNNlkQKDDDVELEKSNILLIGPTGSGKTLLAQTLAKILDVPFAIADATTLTEAGYVGEDVENILLKLLQAADYD 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056  79 VQKAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTVAAVPPQGGRKHPQQEFLQVDTSKILFICGGAFA 158
Cdd:cd19497 111 VERAQRGIVYIDEIDKIARKSENPSITRDVSGEGVQQALLKILEGTVANVPPQGGRKHPQQEFIQVDTTNILFICGGAFV 190

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 52697056 159 GLDKVISHRVETGSgIGFGATVKAKSDKASEGELLAQVEPEDLIKF 204
Cdd:cd19497 191 GLEKIIARRLGKKS-LGFGAETSSEKDEKERDELLSKVEPEDLIKF 235
clpX TIGR00382
endopeptidase Clp ATP-binding regulatory subunit (clpX); A member of the ATP-dependent ...
 1-204 4.72e-132

endopeptidase Clp ATP-binding regulatory subunit (clpX); A member of the ATP-dependent proteases, ClpX has ATP-dependent chaperone activity and is required for specific ATP-dependent proteolytic activities expressed by ClpPX. The gene is also found to be involved in stress tolerance in Bacillus subtilis and is essential for the efficient acquisition of genes specifying type IA and IB restriction. [Protein fate, Protein folding and stabilization, Protein fate, Degradation of proteins, peptides, and glycopeptides]


Pssm-ID: 273047 [Multi-domain]  Cd Length: 413  Bit Score: 376.80  E-value: 4.72e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056     1 HYKRLR---NGDTSNGVELGKSNILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTEAGYVGEDVENIIQKLLQKCDY 77
Cdd:TIGR00382  96 HYKRLNfekNKKSDNGVELSKSNILLIGPTGSGKTLLAQTLARILNVPFAIADATTLTEAGYVGEDVENILLKLLQAADY 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056    78 DVQKAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTVAAVPPQGGRKHPQQEFLQVDTSKILFICGGAF 157
Cdd:TIGR00382 176 DVEKAQKGIIYIDEIDKISRKSENPSITRDVSGEGVQQALLKIIEGTVANVPPQGGRKHPYQEFIQIDTSNILFICGGAF 255

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 52697056   158 AGLDKVISHRVETGSgIGFGATVKAKSDKasEGELLAQVEPEDLIKF 204
Cdd:TIGR00382 256 VGLEKIIKKRTGKSS-IGFGAEVKKKSKE--KADLLRQVEPEDLVKF 299
RecA-like_HslU cd19498
ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease ...
 15-157 4.54e-37

ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease HslVU. In HslVU, HslU ATPase serves to unfold and translocate protein substrate, and the HslV protease degrades the unfolded proteins. This RecA-like_HslU subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410906 [Multi-domain]  Cd Length: 183  Bit Score: 127.11  E-value: 4.54e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056  15 ELGKSNILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTEAGYVGEDVENIIQKLLQkcdydvqkaqrGIVYIDEIDK 94
Cdd:cd19498  43 EVTPKNILMIGPTGVGKTEIARRLAKLAGAPFIKVEATKFTEVGYVGRDVESIIRDLVE-----------GIVFIDEIDK 111

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 52697056  95 ISRKSDnpSITRDVSGEGVQQALLKLIEGTVaaVPPQGGrkhpqqeflQVDTSKILFICGGAF 157
Cdd:cd19498 112 IAKRGG--SSGPDVSREGVQRDLLPIVEGST--VSTKYG---------PVKTDHILFIAAGAF 161
AAA_2 pfam07724
AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected ...
 18-204 3.34e-32

AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400187 [Multi-domain]  Cd Length: 168  Bit Score: 114.21  E-value: 3.34e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056    18 KSNILLIGPTGSGKTLLAETLARLLDV---PFTMADATTLTEagyvgedvENIIQKLLQKCDYDVQKAQRG--------- 85
Cdd:pfam07724   3 IGSFLFLGPTGVGKTELAKALAELLFGderALIRIDMSEYME--------EHSVSRLIGAPPGYVGYEEGGqlteavrrk 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056    86 ---IVYIDEIDKISRksdnpsitrdvsgeGVQQALLKLIEGTVaaVPPQGGRkhpqqeflQVDTSKILFICGGAFAGLDK 162
Cdd:pfam07724  75 pysIVLIDEIEKAHP--------------GVQNDLLQILEGGT--LTDKQGR--------TVDFKNTLFIMTGNFGSEKI 130

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 52697056   163 VIshrvetgsgigfgatvkAKSDKASEGELLAQVEPEDLIKF 204
Cdd:pfam07724 131 SD-----------------ASRLGDSPDYELLKEEVMDLLKK 155
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 4-123 1.12e-22

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 89.26  E-value: 1.12e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056   4 RLRNGDTSNGVELGKSNILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTEA--GYVGEDVENIIQKLLQKcdydvqk 81
Cdd:cd19481  12 PRRGSRLRRYGLGLPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKyvGESEKNLRKIFERARRL------- 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 52697056  82 aQRGIVYIDEIDKISRKSDNPSITRDVSgeGVQQALLKLIEG 123
Cdd:cd19481  85 -APCILFIDEIDAIGRKRDSSGESGELR--RVLNQLLTELDG 123
hslU PRK05201
ATP-dependent protease ATPase subunit HslU;
20-157 7.26e-20

ATP-dependent protease ATPase subunit HslU;


Pssm-ID: 235364 [Multi-domain]  Cd Length: 443  Bit Score: 86.28  E-value: 7.26e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056   20 NILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTEAGYVGEDVENII------------------------------- 68
Cdd:PRK05201  52 NILMIGPTGVGKTEIARRLAKLANAPFIKVEATKFTEVGYVGRDVESIIrdlveiavkmvreekrekvrekaeeaaeeri 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056   69 --------------------------------------------------------------------QKLLQKC----- 75
Cdd:PRK05201 132 ldallppaknnwgeeeekeeisatrqkfrkklregelddkeieievaeaapmmeimgppgmeemtiqlQDMFGNLgpkkk 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056   76 -----------------------DYD--VQKA-----QRGIVYIDEIDKISRKSDNPSitRDVSGEGVQQALLKLIEGTV 125
Cdd:PRK05201 212 kkrklkvkearkilieeeaakliDMEeiKQEAierveQNGIVFIDEIDKIAARGGSSG--PDVSREGVQRDLLPLVEGST 289

                        250       260       270
                 ....*....|....*....|....*....|..
gi 52697056  126 AAVppqggrKHPqqeflQVDTSKILFICGGAF 157
Cdd:PRK05201 290 VST------KYG-----MVKTDHILFIASGAF 310
HslU COG1220
ATP-dependent protease HslVU (ClpYQ), ATPase subunit HslU [Posttranslational modification, ...
 20-157 8.56e-17

ATP-dependent protease HslVU (ClpYQ), ATPase subunit HslU [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440833 [Multi-domain]  Cd Length: 454  Bit Score: 77.78  E-value: 8.56e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056  20 NILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTEAGYVGEDVENII------------------------------- 68
Cdd:COG1220  52 NILMIGPTGVGKTEIARRLAKLANAPFIKVEATKFTEVGYVGRDVESMIrdlveiavkmvreekmekvrekaeeaaeeri 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056  69 -----------------------------------QKLLQK--------------------------------------- 74
Cdd:COG1220 132 ldlllpppkkkagsnnpfeeeeeeeeeeeeisrtrEKFRKKlregelddreieieveessspgveimgppgmeemgmnlq 211

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056  75 ---------------------------------CDYD--VQKA-----QRGIVYIDEIDKISRKSDNPSItrDVSGEGVQ 114
Cdd:COG1220 212 dmfgnlmpkkkkkrkvkvkearkiltqeeaaklIDMDevKQEAieraeQNGIIFIDEIDKIASRGGGSGP--DVSREGVQ 289

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 52697056 115 QALLKLIEG-TVAAvppqggrKHPqqeflQVDTSKILFICGGAF 157
Cdd:COG1220 290 RDLLPIVEGsTVNT-------KYG-----MVKTDHILFIAAGAF 321
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 21-153 1.73e-16

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 72.24  E-value: 1.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056    21 ILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTEaGYVGEDVENIIQKLLQkcdydVQKAQRGIVYIDEIDKISRKSD 100
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVS-KYVGESEKRLRELFEA-----AKKLAPCVIFIDEIDALAGSRG 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 52697056   101 NPSitrDVSGEGVQQALLKLIEGtvaavppqggrkhpqqefLQVDTSKILFIC 153
Cdd:pfam00004  75 SGG---DSESRRVVNQLLTELDG------------------FTSSNSKVIVIA 106
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 18-101 2.53e-15

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 69.87  E-value: 2.53e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056  18 KSNILLIGPTGSGKTLLAETLARLL---DVPFTMADATTLTEAGYVGEDVENIIQKLLQKcdyDVQKAQRGIVYIDEIDK 94
Cdd:cd00009  19 PKNLLLYGPPGTGKTTLARAIANELfrpGAPFLYLNASDLLEGLVVAELFGHFLVRLLFE---LAEKAKPGVLFIDEIDS 95


                ....*..
gi 52697056  95 ISRKSDN 101
Cdd:cd00009  96 LSRGAQN 102
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 13-123 2.37e-13

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 67.63  E-value: 2.37e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056  13 GVELGKSnILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTeAGYVGEDVENiIQKLLQKcdydVQKAQRGIVYIDEI 92
Cdd:COG0464 187 GLPPPRG-LLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLV-SKYVGETEKN-LREVFDK----ARGLAPCVLFIDEA 259

                        90       100       110
                ....*....|....*....|....*....|.
gi 52697056  93 DKISRKSDNpsiTRDVSGEGVQQALLKLIEG 123
Cdd:COG0464 260 DALAGKRGE---VGDGVGRRVVNTLLTEMEE 287
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 21-123 7.77e-12

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 60.77  E-value: 7.77e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056  21 ILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTeAGYVGEDVENiiqklLQKCDYDVQKAQRGIVYIDEIDKI--SRK 98
Cdd:cd19503  37 VLLHGPPGTGKTLLARAVANEAGANFLSISGPSIV-SKYLGESEKN-----LREIFEEARSHAPSIIFIDEIDALapKRE 110

                        90       100
                ....*....|....*....|....*
gi 52697056  99 SDNPSITRDVsgegVQQaLLKLIEG 123
Cdd:cd19503 111 EDQREVERRV----VAQ-LLTLMDG 130
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 21-117 8.38e-09

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 52.79  E-value: 8.38e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056  21 ILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTeAGYVGEDVENiIQKLlqkcdYDVQKAQR-GIVYIDEIDKISRKS 99
Cdd:cd19518  37 VLLHGPPGCGKTMLANAIAGELKVPFLKISATEIV-SGVSGESEEK-IREL-----FDQAISNApCIVFIDEIDAITPKR 109

                        90
                ....*....|....*...
gi 52697056 100 DNPSitRDVSGEGVQQAL 117
Cdd:cd19518 110 ESAQ--REMERRIVSQLL 125
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 13-123 1.21e-08

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 53.86  E-value: 1.21e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056  13 GVELGKSnILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTEAgYVGEDvENIIQKLLQKcdydVQKAQRGIVYIDEI 92
Cdd:COG1222 108 GIEPPKG-VLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSK-YIGEG-ARNVREVFEL----AREKAPSIIFIDEI 180

                        90       100       110
                ....*....|....*....|....*....|...
gi 52697056  93 DKISRKSDNpSITrdvSGEG--VQQALLKLIEG 123
Cdd:COG1222 181 DAIAARRTD-DGT---SGEVqrTVNQLLAELDG 209
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 21-127 1.31e-07

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 49.27  E-value: 1.31e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056  21 ILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTeAGYVGEDvENIIQKLlqkcdYDV-QKAQRGIVYIDEIDKI--SR 97
Cdd:cd19509  35 ILLYGPPGTGKTLLARAVASESGSTFFSISASSLV-SKWVGES-EKIVRAL-----FALaRELQPSIIFIDEIDSLlsER 107

                        90       100       110
                ....*....|....*....|....*....|
gi 52697056  98 KSDNPSITRDVSGEgvqqaLLKLIEGTVAA 127
Cdd:cd19509 108 GSGEHEASRRVKTE-----FLVQMDGVLNK 132
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 20-97 1.85e-07

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 48.44  E-value: 1.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056    20 NILLIGPTGSGKTLLAETLARLLD--VPFTMADATTLTEAGYVGE-DVENIIQKLLQKCdyDVQKAQRG-IVYIDEIDKI 95
Cdd:pfam07728   1 GVLLVGPPGTGKTELAERLAAALSnrPVFYVQLTRDTTEEDLFGRrNIDPGGASWVDGP--LVRAAREGeIAVLDEINRA 78


                  ..
gi 52697056    96 SR 97
Cdd:pfam07728  79 NP 80
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 13-123 2.44e-07

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 50.29  E-value: 2.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056    13 GVELGKSnILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTeAGYVGEDVENiiqklLQKCDYDVQKAQRGIVYIDEI 92
Cdd:TIGR01243 208 GIEPPKG-VLLYGPPGTGKTLLAKAVANEAGAYFISINGPEIM-SKYYGESEER-----LREIFKEAEENAPSIIFIDEI 280

                          90       100       110
                  ....*....|....*....|....*....|.
gi 52697056    93 DKISRKSDnpSITRDVSGEGVQQaLLKLIEG 123
Cdd:TIGR01243 281 DAIAPKRE--EVTGEVEKRVVAQ-LLTLMDG 308
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
 21-98 9.78e-07

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 46.84  E-value: 9.78e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 52697056  21 ILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTEAgYVGEDVENiIQKLLQKcdydVQKAQRGIVYIDEIDKISRK 98
Cdd:cd19501  40 VLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEM-FVGVGASR-VRDLFEQ----AKKNAPCIVFIDEIDAVGRK 111
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 18-98 1.17e-06

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 46.60  E-value: 1.17e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056     18 KSNILLIGPTGSGKTLLAETLARLLDVP---FTMADATTLTEAGYVGEDVENIIQKLLQKCDYD--------VQKAQRGI 86
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPPgggVIYIDGEDILEEVLDQLLLIIVGGKKASGSGELrlrlalalARKLKPDV 81

                           90
                   ....*....|..
gi 52697056     87 VYIDEIDKISRK 98
Cdd:smart00382  82 LILDEITSLLDA 93
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
21-98 1.30e-06

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 48.11  E-value: 1.30e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 52697056   21 ILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTEAgYVGEDVENIIQKLLQkcdydVQKAQRGIVYIDEIDKISRK 98
Cdd:PRK10733 188 VLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEM-FVGVGASRVRDMFEQ-----AKKAAPCIIFIDEIDAVGRQ 259
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 21-97 2.09e-06

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 45.88  E-value: 2.09e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 52697056  21 ILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTEAGYvGEDveniiQKLLQKCDYDVQKAQRGIVYIDEIDKISR 97
Cdd:cd19520  38 VLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWY-GES-----QKLVAAVFSLASKLQPSIIFIDEIDSFLR 108
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 21-111 2.47e-06

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 45.61  E-value: 2.47e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056  21 ILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTeAGYVGEDvENIIQKLLQKcdydVQKAQRGIVYIDEIDKI--SRK 98
Cdd:cd19524  36 LLLFGPPGNGKTMLAKAVAAESNATFFNISAASLT-SKYVGEG-EKLVRALFAV----ARELQPSIIFIDEVDSLlsERS 109

                        90
                ....*....|...
gi 52697056  99 SDNPSITRDVSGE 111
Cdd:cd19524 110 EGEHEASRRLKTE 122
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 21-123 5.16e-06

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 44.73  E-value: 5.16e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056  21 ILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTeAGYVGEDVENiiqklLQKCDYDVQKAQRGIVYIDEIDKISRKSD 100
Cdd:cd19519  37 ILLYGPPGTGKTLIARAVANETGAFFFLINGPEIM-SKLAGESESN-----LRKAFEEAEKNAPAIIFIDEIDAIAPKRE 110

                        90       100
                ....*....|....*....|...
gi 52697056 101 NpsITRDVSGEGVQQaLLKLIEG 123
Cdd:cd19519 111 K--THGEVERRIVSQ-LLTLMDG 130
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 21-118 5.20e-06

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 45.93  E-value: 5.20e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056  21 ILLIGPTGSGKTLLAETLARLLDVPF--------TM-ADATtlteaG---YVGEDVENIIQK--LLQkcdydvqkaqrGI 86
Cdd:COG0714  34 LLLEGVPGVGKTTLAKALARALGLPFiriqftpdLLpSDIL-----GtyiYDQQTGEFEFRPgpLFA-----------NV 97

                        90       100       110
                ....*....|....*....|....*....|..
gi 52697056  87 VYIDEIDKISRKsdnpsitrdvsgegVQQALL 118
Cdd:COG0714  98 LLADEINRAPPK--------------TQSALL 115
ftsH CHL00176
cell division protein; Validated
 21-98 5.95e-06

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 46.20  E-value: 5.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056   21 ILLIGPTGSGKTLLAETLARLLDVPFtmadattLTEAGyvGEDVENIIQKLLQKCDYDVQKAQRG---IVYIDEIDKISR 97
Cdd:CHL00176 219 VLLVGPPGTGKTLLAKAIAGEAEVPF-------FSISG--SEFVEMFVGVGAARVRDLFKKAKENspcIVFIDEIDAVGR 289


                 .
gi 52697056   98 K 98
Cdd:CHL00176 290 Q 290
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
 21-135 7.91e-06

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 44.59  E-value: 7.91e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056  21 ILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTeAGYVGEDveniiQKLLqKCDYDVQKAQR-GIVYIDEIDKI-SRK 98
Cdd:cd19522  36 VLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLT-SKYRGES-----EKLV-RLLFEMARFYApTTIFIDEIDSIcSRR 108

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 52697056  99 --SDNPSITRDVSGEgvqqaLLKLIEGTVAAVPPQGGRK 135
Cdd:cd19522 109 gtSEEHEASRRVKSE-----LLVQMDGVGGASENDDPSK 142
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 9-100 8.19e-06

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 44.59  E-value: 8.19e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056   9 DTSNGVELGKSNILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTeAGYVGEDvENIIQKLlqkcdYDVQKAQR-GIV 87
Cdd:cd19525  46 DIFTGLRGPPKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLT-SKWVGEG-EKMVRAL-----FSVARCKQpAVI 118

                        90
                ....*....|....
gi 52697056  88 YIDEIDK-ISRKSD 100
Cdd:cd19525 119 FIDEIDSlLSQRGE 132
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 14-125 1.23e-05

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 45.08  E-value: 1.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056   14 VELGK-SNILLIGPTGSGKTLLAETLARLLDVPFTMADATTlteAGyVgEDVENIIQKLLQKCDYDvqkaQRGIVYIDEI 92
Cdd:PRK13342  31 IEAGRlSSMILWGPPGTGKTTLARIIAGATDAPFEALSAVT---SG-V-KDLREVIEEARQRRSAG----RRTILFIDEI 101

                         90       100       110
                 ....*....|....*....|....*....|....
gi 52697056   93 DKISRKSdnpsitrdvsgegvQQALLKLIE-GTV 125
Cdd:PRK13342 102 HRFNKAQ--------------QDALLPHVEdGTI 121
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 18-120 1.47e-05

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 43.66  E-value: 1.47e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056  18 KSNILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTEAgYVGEDVENiIQKLLQKcdydVQKAQRGIVYIDEIDKISR 97
Cdd:cd19527  26 RSGILLYGPPGTGKTLLAKAIATECSLNFLSVKGPELINM-YIGESEAN-VREVFQK----ARDAKPCVIFFDELDSLAP 99

                        90       100
                ....*....|....*....|...
gi 52697056  98 KSDNPSITRDVSGEGVQQALLKL 120
Cdd:cd19527 100 SRGNSGDSGGVMDRVVSQLLAEL 122
AAA_22 pfam13401
AAA domain;
14-101 1.73e-05

AAA domain;


Pssm-ID: 379165 [Multi-domain]  Cd Length: 129  Bit Score: 42.71  E-value: 1.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056    14 VELGKSNILLIGPTGSGKTLLAETLARLLD------VPFTMADATTLTE-----AGYVGEDVENIIQK---LLQKCDYDV 79
Cdd:pfam13401   1 IRFGAGILVLTGESGTGKTTLLRRLLEQLPevrdsvVFVDLPSGTSPKDllralLRALGLPLSGRLSKeelLAALQQLLL 80

                          90       100
                  ....*....|....*....|..
gi 52697056    80 QKAQRGIVYIDEIDKISRKSDN 101
Cdd:pfam13401  81 ALAVAVVLIIDEAQHLSLEALE 102
RecA-like_Lon cd19500
lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an ...
 21-153 2.89e-05

lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an evolutionarily conserved ATP-dependent serine protease, present in bacteria and eukaryotic mitochondria and peroxisomes, which mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Lon protease is both an ATP-dependent peptidase and a protein-activated ATPase. This RecA-like Lon domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410908 [Multi-domain]  Cd Length: 182  Bit Score: 42.93  E-value: 2.89e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056  21 ILLIGPTGSGKTLLAETLARLLDVPFT------MADattltEA-------GYVGEDVENIIQKlLQKCdydvqKAQRGIV 87
Cdd:cd19500  40 LCLVGPPGVGKTSLGKSIARALGRKFVrislggVRD-----EAeirghrrTYVGAMPGRIIQA-LKKA-----GTNNPVF 108

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 52697056  88 YIDEIDKISRKSD-NPSitrdvsgegvqQALLKLIEgtvaavPPQGGRKHPQQEFLQVDTSKILFIC 153
Cdd:cd19500 109 LLDEIDKIGSSFRgDPA-----------SALLEVLD------PEQNSTFSDHYLDVPFDLSKVLFIA 158
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 21-121 3.03e-05

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 42.71  E-value: 3.03e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056  21 ILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTEAgYVGEDVEnIIQKLLQKcdydVQKAQRGIVYIDEIDKI--SRK 98
Cdd:cd19502  40 VLLYGPPGTGKTLLAKAVANHTDATFIRVVGSELVQK-YIGEGAR-LVRELFEM----AREKAPSIIFIDEIDAIgaKRF 113

                        90       100
                ....*....|....*....|...
gi 52697056  99 SDNPSITRDvsgegVQQALLKLI 121
Cdd:cd19502 114 DSGTGGDRE-----VQRTMLELL 131
YifB COG0606
Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational ...
 20-42 4.71e-05

Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440371 [Multi-domain]  Cd Length: 502  Bit Score: 43.11  E-value: 4.71e-05
                        10        20
                ....*....|....*....|...
gi 52697056  20 NILLIGPTGSGKTLLAETLARLL 42
Cdd:COG0606 213 NLLMIGPPGSGKTMLARRLPGIL 235
clpC CHL00095
Clp protease ATP binding subunit
 18-92 4.81e-05

Clp protease ATP binding subunit


Pssm-ID: 214361 [Multi-domain]  Cd Length: 821  Bit Score: 43.51  E-value: 4.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056   18 KSNILLIGPTGSGKTLLAETLARLL---DVPFTMAD--------ATTLTEAGYVGEdVENIIQKLLQkcdyDVQKAQRGI 86
Cdd:CHL00095 200 KNNPILIGEPGVGKTAIAEGLAQRIvnrDVPDILEDklvitldiGLLLAGTKYRGE-FEERLKRIFD----EIQENNNII 274


                 ....*.
gi 52697056   87 VYIDEI 92
Cdd:CHL00095 275 LVIDEV 280
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
 18-120 5.47e-05

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 41.65  E-value: 5.47e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056  18 KSNILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTeAGYVGEDVENiIQKLLQKcdydVQKAQRGIVYIDEIDKIS- 96
Cdd:cd19526  27 RSGILLYGPPGCGKTLLASAIASECGLNFISVKGPELL-NKYIGASEQN-VRDLFSR----AQSAKPCILFFDEFDSIAp 100

                        90       100
                ....*....|....*....|....*
gi 52697056  97 -RKSDNPSITRDVsgegVQQALLKL 120
Cdd:cd19526 101 kRGHDSTGVTDRV----VNQLLTQL 121
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 21-103 1.33e-04

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 40.73  E-value: 1.33e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056  21 ILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTEAgYVGEDvENIIQKLLQKcdydVQKAQRGIVYIDEIDKI-SRKS 99
Cdd:cd19511  30 VLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSK-YVGES-ERAVREIFQK----ARQAAPCIIFFDEIDSLaPRRG 103


                ....
gi 52697056 100 DNPS 103
Cdd:cd19511 104 QSDS 107
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
 20-107 1.60e-04

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 40.20  E-value: 1.60e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056  20 NILLIGPTGSGKTLLAETLARLLDVPFTMadaTTLTEAGYVGEDVENIIQKLLqkcDYdVQKAQRG-IVYIDEIDKISRK 98
Cdd:cd19512  24 NILFYGPPGTGKTLFAKKLALHSGMDYAI---MTGGDVAPMGREGVTAIHKVF---DW-ANTSRRGlLLFVDEADAFLRK 96


                ....*....
gi 52697056  99 SDNPSITRD 107
Cdd:cd19512  97 RSTEKISED 105
clpA PRK11034
ATP-dependent Clp protease ATP-binding subunit; Provisional
 18-95 1.96e-04

ATP-dependent Clp protease ATP-binding subunit; Provisional


Pssm-ID: 236828 [Multi-domain]  Cd Length: 758  Bit Score: 41.75  E-value: 1.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056   18 KSNILLIGPTGSGKTLLAETLA-RLL--DVPFTMADATT--------LTEAGYVGeDVENIIQKLLQKcdydVQKAQRGI 86
Cdd:PRK11034 207 KNNPLLVGESGVGKTAIAEGLAwRIVqgDVPEVMADCTIysldigslLAGTKYRG-DFEKRFKALLKQ----LEQDTNSI 281


                 ....*....
gi 52697056   87 VYIDEIDKI 95
Cdd:PRK11034 282 LFIDEIHTI 290
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 21-98 2.99e-04

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 41.05  E-value: 2.99e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 52697056    21 ILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTeAGYVGEDvENIIQKLLQKcdydVQKAQRGIVYIDEIDKISRK 98
Cdd:TIGR01243 490 VLLFGPPGTGKTLLAKAVATESGANFIAVRGPEIL-SKWVGES-EKAIREIFRK----ARQAAPAIIFFDEIDAIAPA 561
Mg_chelatase pfam01078
Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that ...
 17-51 3.31e-04

Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that catalyzes the insertion of Mg2+ into protoporphyrin IX. This is the first unique step in the synthesis of (bacterio)chlorophyll. Due to this, it is thought that Mg-chelatase has an important role in channelling inter- mediates into the (bacterio)chlorophyll branch in response to conditions suitable for photosynthetic growth. ChlI and BchD have molecular weight between 38-42 kDa.


Pssm-ID: 426032 [Multi-domain]  Cd Length: 207  Bit Score: 40.21  E-value: 3.31e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 52697056    17 GKSNILLIGPTGSGKTLLAETLARLLDvPFTMADA 51
Cdd:pfam01078  21 GGHNLLMIGPPGSGKTMLAKRLPGILP-PLTEAEA 54
RecA-like_NSF-SEC18_r1-like cd19504
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...
 21-123 3.60e-04

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410912 [Multi-domain]  Cd Length: 177  Bit Score: 39.78  E-value: 3.60e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056  21 ILLIGPTGSGKTLLAETLARLLDV--PFTMADATTLTEagYVGEDVENiIQKLLQkcDYDVQKAQRG------IVYIDEI 92
Cdd:cd19504  38 ILLYGPPGTGKTLMARQIGKMLNArePKIVNGPEILNK--YVGESEAN-IRKLFA--DAEEEQRRLGansglhIIIFDEI 112

                        90       100       110
                ....*....|....*....|....*....|...
gi 52697056  93 DKISRKSDNpsiTRDVSGEG--VQQALLKLIEG 123
Cdd:cd19504 113 DAICKQRGS---MAGSTGVHdtVVNQLLSKIDG 142
aroK PRK00131
shikimate kinase; Reviewed
 16-46 3.80e-04

shikimate kinase; Reviewed


Pssm-ID: 234654 [Multi-domain]  Cd Length: 175  Bit Score: 39.40  E-value: 3.80e-04
                         10        20        30
                 ....*....|....*....|....*....|.
gi 52697056   16 LGKSNILLIGPTGSGKTLLAETLARLLDVPF 46
Cdd:PRK00131   2 LKGPNIVLIGFMGAGKSTIGRLLAKRLGYDF 32
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 21-120 5.18e-04

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 39.02  E-value: 5.18e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056  21 ILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTeAGYVGEDvENIIQKLLQKcdydVQKAQRGIVYIDEIDKIS--RK 98
Cdd:cd19529  30 ILLYGPPGTGKTLLAKAVATESNANFISVKGPELL-SKWVGES-EKAIREIFRK----ARQVAPCVIFFDEIDSIAprRG 103

                        90       100
                ....*....|....*....|..
gi 52697056  99 SDNPSitrDVSGEGVQQALLKL 120
Cdd:cd19529 104 TTGDS---GVTERVVNQLLTEL 122
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 19-103 7.81e-04

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 38.69  E-value: 7.81e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056  19 SNILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTeAGYVGEDvENIIQKLLQKcdydVQKAQRGIVYIDEIDKI-SR 97
Cdd:cd19521  41 SGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLV-SKWMGES-EKLVKQLFAM----ARENKPSIIFIDEVDSLcGT 114


                ....*.
gi 52697056  98 KSDNPS 103
Cdd:cd19521 115 RGEGES 120
CDC6 COG1474
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
19-101 9.25e-04

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 39.45  E-value: 9.25e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056  19 SNILLIGPTGSGKTLLA-------ETLARLLDVPFTMA-----DATTLTEA-----------------GYVGEDVENIIQ 69
Cdd:COG1474  52 SNVLIYGPTGTGKTAVAkyvleelEEEAEERGVDVRVVyvncrQASTRYRVlsrileelgsgedipstGLSTDELFDRLY 131

                        90       100       110
                ....*....|....*....|....*....|..
gi 52697056  70 KLLQKCDYDVqkaqrgIVYIDEIDKISRKSDN 101
Cdd:COG1474 132 EALDERDGVL------VVVLDEIDYLVDDEGD 157
SK cd00464
Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic ...
 20-50 9.78e-04

Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids, p-aminobenzoic acid, folate and ubiquinone. Shikimate kinase catalyses the phosphorylation of the 3-hydroxyl group of shikimic acid using ATP.


Pssm-ID: 238260 [Multi-domain]  Cd Length: 154  Bit Score: 38.31  E-value: 9.78e-04
                        10        20        30
                ....*....|....*....|....*....|.
gi 52697056  20 NILLIGPTGSGKTLLAETLARLLDVPFTMAD 50
Cdd:cd00464   1 NIVLIGMMGAGKTTVGRLLAKALGLPFVDLD 31
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
 21-94 1.26e-03

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 38.12  E-value: 1.26e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 52697056  21 ILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTeAGYVGEDVENIIQKL-----LQKCdydvqkaqrgIVYIDEIDK 94
Cdd:cd19507  34 LLLVGIQGTGKSLTAKAIAGVWQLPLLRLDMGRLF-GGLVGESESRLRQMIqtaeaIAPC----------VLWIDEIEK 101
PspF COG1221
Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain ...
 20-38 2.27e-03

Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription, Signal transduction mechanisms];


Pssm-ID: 440834 [Multi-domain]  Cd Length: 835  Bit Score: 38.17  E-value: 2.27e-03
                        10
                ....*....|....*....
gi 52697056  20 NILLIGPTGSGKTLLAETL 38
Cdd:COG1221 132 HTLILGPTGVGKSFFAELM 150
NadR3 COG3172
Nicotinamide riboside kinase [Coenzyme transport and metabolism]; Nicotinamide riboside kinase ...
 21-90 2.57e-03

Nicotinamide riboside kinase [Coenzyme transport and metabolism]; Nicotinamide riboside kinase is part of the Pathway/BioSystem: NAD biosynthesis


Pssm-ID: 442405 [Multi-domain]  Cd Length: 178  Bit Score: 37.11  E-value: 2.57e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 52697056  21 ILLIGPTGSGKTLLAETLARLLDVP--------FTMADATTLTEagyvgEDVENIIQKLLQKCDYDVQKAqRGIVYID 90
Cdd:COG3172  11 IVLLGAESTGKTTLARALAAHYNTPwvpeygreYLEEKGRALTY-----DDLLAIARGQLALEDAAAKRA-NKLLFCD 82
PRK13946 PRK13946
shikimate kinase; Provisional
 16-50 2.69e-03

shikimate kinase; Provisional


Pssm-ID: 184411 [Multi-domain]  Cd Length: 184  Bit Score: 37.21  E-value: 2.69e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 52697056   16 LGKSNILLIGPTGSGKTLLAETLARLLDVPFTMAD 50
Cdd:PRK13946   8 LGKRTVVLVGLMGAGKSTVGRRLATMLGLPFLDAD 42
AroK COG0703
Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the ...
 21-46 2.75e-03

Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 440467 [Multi-domain]  Cd Length: 165  Bit Score: 37.03  E-value: 2.75e-03
                        10        20
                ....*....|....*....|....*.
gi 52697056  21 ILLIGPTGSGKTLLAETLARLLDVPF 46
Cdd:COG0703   1 IVLIGMMGAGKSTVGRLLAKRLGLPF 26
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 21-93 2.94e-03

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 36.79  E-value: 2.94e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 52697056  21 ILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTeAGYVGEDvENIIQK--LLQKCdydvqkAQRGIVYIDEID 93
Cdd:cd19523  36 ILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLV-AKWAGEG-EKILQAsfLAARC------RQPSVLFISDLD 102
ycf46 CHL00195
Ycf46; Provisional
 21-101 4.36e-03

Ycf46; Provisional


Pssm-ID: 177094 [Multi-domain]  Cd Length: 489  Bit Score: 37.31  E-value: 4.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056   21 ILLIGPTGSGKTLLAETLARLLDVPFTMADATTLTeAGYVGED---VENIIQ--KLLQKCdydvqkaqrgIVYIDEIDKI 95
Cdd:CHL00195 262 LLLVGIQGTGKSLTAKAIANDWQLPLLRLDVGKLF-GGIVGESesrMRQMIRiaEALSPC----------ILWIDEIDKA 330


                 ....*.
gi 52697056   96 SRKSDN 101
Cdd:CHL00195 331 FSNSES 336
RecA-like_ClpB_Hsp104-like cd19499
Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and ...
 22-94 4.95e-03

Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and eukaryotic Heat shock protein 104 (Hsp104) are ATP-dependent molecular chaperones and essential proteins of the heat-shock response. ClpB/Hsp104 ATPases, in concert with the DnaK/Hsp70 chaperone system, disaggregate and reactivate aggregated proteins. This RecA-like_ClpB_Hsp104_like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410907 [Multi-domain]  Cd Length: 178  Bit Score: 36.39  E-value: 4.95e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056  22 LLIGPTGSGKTLLAETLARLL---DVPFTMAD---------ATTLTEA--GYVGEDVeniIQKLLQKcdydVQKAQRGIV 87
Cdd:cd19499  45 LFLGPTGVGKTELAKALAELLfgdEDNLIRIDmseymekhsVSRLIGAppGYVGYTE---GGQLTEA----VRRKPYSVV 117


                ....*..
gi 52697056  88 YIDEIDK 94
Cdd:cd19499 118 LLDEIEK 124
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
 21-121 4.98e-03

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 37.05  E-value: 4.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52697056   21 ILLIGPTGSGKTLLAETLARlldvpftmadATTLTEAGYVGEDvenIIQKLL---QKCDYDVQKAQR----GIVYIDEID 93
Cdd:PTZ00454 182 VLLYGPPGTGKTMLAKAVAH----------HTTATFIRVVGSE---FVQKYLgegPRMVRDVFRLARenapSIIFIDEVD 248

                         90       100
                 ....*....|....*....|....*...
gi 52697056   94 KISRKSDNPSITRDvsgEGVQQALLKLI 121
Cdd:PTZ00454 249 SIATKRFDAQTGAD---REVQRILLELL 273
TIP49 COG1224
DNA helicase TIP49, TBP-interacting protein [Transcription];
21-51 5.20e-03

DNA helicase TIP49, TBP-interacting protein [Transcription];


Pssm-ID: 440837 [Multi-domain]  Cd Length: 452  Bit Score: 37.26  E-value: 5.20e-03
                        10        20        30
                ....*....|....*....|....*....|...
gi 52697056  21 ILLIGPTGSGKTLLAETLARLL--DVPFTMADA 51
Cdd:COG1224  67 ILIVGPPGTGKTALAVAIARELgeDTPFVAISG 99
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 21-44 7.75e-03

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 35.97  E-value: 7.75e-03
                        10        20
                ....*....|....*....|....
gi 52697056  21 ILLIGPTGSGKTLLAETLARLLDV 44
Cdd:COG0572  10 IGIAGPSGSGKTTFARRLAEQLGA 33
MiaA COG0324
tRNA A37 N6-isopentenylltransferase MiaA [Translation, ribosomal structure and biogenesis]; ...
 21-44 9.06e-03

tRNA A37 N6-isopentenylltransferase MiaA [Translation, ribosomal structure and biogenesis]; tRNA A37 N6-isopentenylltransferase MiaA is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440093  Cd Length: 306  Bit Score: 36.19  E-value: 9.06e-03
                        10        20
                ....*....|....*....|....
gi 52697056  21 ILLIGPTGSGKTLLAETLARLLDV 44
Cdd:COG0324   5 IVIVGPTASGKTALAIELAKRLGG 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH