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Conserved domains on  [gi|45445615|gb|AAS64883|]
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eiger, isoform B [Drosophila melanogaster]

Protein Classification

TNF domain-containing protein( domain architecture ID 10075925)

TNF domain-containing protein similar to Homo sapiens lymphotoxin-alpha, which acts as cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TNF cd00184
Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT ...
 272-407 6.16e-24

Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal domain, a short transmembrane segment, an extracellular stalk, and a globular TNF-like extracellular domain of about 150 residues. They initiate apoptosis by binding to related receptors, some of which have intracellular death domains. They generally form homo- or hetero- trimeric complexes.TNF cytokines bind one elongated receptor molecule along each of three clefts formed by neighboring monomers of the trimer with ligand trimerization a requiste for receptor binding.


:

Pssm-ID: 238108  Cd Length: 137  Bit Score: 96.26  E-value: 6.16e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445615 272 PAAHFHLSSRRRhqgsmGYHGDMYIGNDneRNSYQ-GHFQTRDGVLTVTNTGLYYVYAQICYNNSHDQNGF--IVFQGDT 348
Cdd:cd00184   1 PAAHLIGTNSSS-----GGTGLSWESDD--GRAFLsGGLELQNGELVVPQDGLYYIYSQVYFRGQCCSTLSvsHVLQLRT 73

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 45445615 349 ---PFLQCLNTVPTNMPHKV-----HTCHTSGLIHLERNERIHLKDihnDRNAVLREGNNRSYFGIF 407
Cdd:cd00184  74 dsyPEPILLLKGIRSVCSSVsegwyNSVYLGGLFQLRAGDRLSVNV---SAPALLDLSQGTTFFGAF 137
 
Name Accession Description Interval E-value
TNF cd00184
Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT ...
 272-407 6.16e-24

Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal domain, a short transmembrane segment, an extracellular stalk, and a globular TNF-like extracellular domain of about 150 residues. They initiate apoptosis by binding to related receptors, some of which have intracellular death domains. They generally form homo- or hetero- trimeric complexes.TNF cytokines bind one elongated receptor molecule along each of three clefts formed by neighboring monomers of the trimer with ligand trimerization a requiste for receptor binding.


Pssm-ID: 238108  Cd Length: 137  Bit Score: 96.26  E-value: 6.16e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445615 272 PAAHFHLSSRRRhqgsmGYHGDMYIGNDneRNSYQ-GHFQTRDGVLTVTNTGLYYVYAQICYNNSHDQNGF--IVFQGDT 348
Cdd:cd00184   1 PAAHLIGTNSSS-----GGTGLSWESDD--GRAFLsGGLELQNGELVVPQDGLYYIYSQVYFRGQCCSTLSvsHVLQLRT 73

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 45445615 349 ---PFLQCLNTVPTNMPHKV-----HTCHTSGLIHLERNERIHLKDihnDRNAVLREGNNRSYFGIF 407
Cdd:cd00184  74 dsyPEPILLLKGIRSVCSSVsegwyNSVYLGGLFQLRAGDRLSVNV---SAPALLDLSQGTTFFGAF 137
TNF pfam00229
TNF(Tumour Necrosis Factor) family;
302-409 5.07e-09

TNF(Tumour Necrosis Factor) family;


Pssm-ID: 425540  Cd Length: 127  Bit Score: 54.24  E-value: 5.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445615   302 RNSYQGHFQT-----RDGVLTVTNTGLYYVYAQICYNN---SHDQNGFIV--------FQGDTPFLQCLNTVPT--NMPH 363
Cdd:pfam00229   4 ESDRGGAFLLngvtySNGELVVPQAGLYYVYSQVYFRGegcPSGSVPLTHylykfsssYPGPVLLLKGAESPCSseNPEY 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 45445615   364 KVHTCHTSGLIHLERNERIHLkDIHNDRNAVLREgNNRSYFGIFKV 409
Cdd:pfam00229  84 WYQSIYLGGLFELRAGDRLSV-NVSNPSLVDLSA-PGKTYFGAFLL 127
TNF smart00207
Tumour necrosis factor family; Family of cytokines that form homotrimeric or heterotrimeric ...
 312-409 5.37e-06

Tumour necrosis factor family; Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor.


Pssm-ID: 214557  Cd Length: 125  Bit Score: 45.42  E-value: 5.37e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445615    312 RDGVLTVTNTGLYYVYAQICY------NNSHDQNGFIVFQGDT-PF-LQCLNTVPTNMPHKVHTCHTS----GLIHLERN 379
Cdd:smart00207  19 QNGELVVPRDGLYYIYSQVYFrgqgcnGKSVELSLSLHLRKPSyPLpLLLLEAARSSCWSASSAWKDSvylgGLFPLTAG 98

                           90       100       110
                   ....*....|....*....|....*....|
gi 45445615    380 ERIHlkdIHNDRNAVLREGNNRSYFGIFKV 409
Cdd:smart00207  99 DRLS---VNVTEPSLVDLAPGATFFGAFLV 125
 
Name Accession Description Interval E-value
TNF cd00184
Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT ...
 272-407 6.16e-24

Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal domain, a short transmembrane segment, an extracellular stalk, and a globular TNF-like extracellular domain of about 150 residues. They initiate apoptosis by binding to related receptors, some of which have intracellular death domains. They generally form homo- or hetero- trimeric complexes.TNF cytokines bind one elongated receptor molecule along each of three clefts formed by neighboring monomers of the trimer with ligand trimerization a requiste for receptor binding.


Pssm-ID: 238108  Cd Length: 137  Bit Score: 96.26  E-value: 6.16e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445615 272 PAAHFHLSSRRRhqgsmGYHGDMYIGNDneRNSYQ-GHFQTRDGVLTVTNTGLYYVYAQICYNNSHDQNGF--IVFQGDT 348
Cdd:cd00184   1 PAAHLIGTNSSS-----GGTGLSWESDD--GRAFLsGGLELQNGELVVPQDGLYYIYSQVYFRGQCCSTLSvsHVLQLRT 73

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 45445615 349 ---PFLQCLNTVPTNMPHKV-----HTCHTSGLIHLERNERIHLKDihnDRNAVLREGNNRSYFGIF 407
Cdd:cd00184  74 dsyPEPILLLKGIRSVCSSVsegwyNSVYLGGLFQLRAGDRLSVNV---SAPALLDLSQGTTFFGAF 137
TNF pfam00229
TNF(Tumour Necrosis Factor) family;
302-409 5.07e-09

TNF(Tumour Necrosis Factor) family;


Pssm-ID: 425540  Cd Length: 127  Bit Score: 54.24  E-value: 5.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445615   302 RNSYQGHFQT-----RDGVLTVTNTGLYYVYAQICYNN---SHDQNGFIV--------FQGDTPFLQCLNTVPT--NMPH 363
Cdd:pfam00229   4 ESDRGGAFLLngvtySNGELVVPQAGLYYVYSQVYFRGegcPSGSVPLTHylykfsssYPGPVLLLKGAESPCSseNPEY 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 45445615   364 KVHTCHTSGLIHLERNERIHLkDIHNDRNAVLREgNNRSYFGIFKV 409
Cdd:pfam00229  84 WYQSIYLGGLFELRAGDRLSV-NVSNPSLVDLSA-PGKTYFGAFLL 127
TNF smart00207
Tumour necrosis factor family; Family of cytokines that form homotrimeric or heterotrimeric ...
 312-409 5.37e-06

Tumour necrosis factor family; Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor.


Pssm-ID: 214557  Cd Length: 125  Bit Score: 45.42  E-value: 5.37e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445615    312 RDGVLTVTNTGLYYVYAQICY------NNSHDQNGFIVFQGDT-PF-LQCLNTVPTNMPHKVHTCHTS----GLIHLERN 379
Cdd:smart00207  19 QNGELVVPRDGLYYIYSQVYFrgqgcnGKSVELSLSLHLRKPSyPLpLLLLEAARSSCWSASSAWKDSvylgGLFPLTAG 98

                           90       100       110
                   ....*....|....*....|....*....|
gi 45445615    380 ERIHlkdIHNDRNAVLREGNNRSYFGIFKV 409
Cdd:smart00207  99 DRLS---VNVTEPSLVDLAPGATFFGAFLV 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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