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Conserved domains on  [gi|38112388|gb|AAR11280|]
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Ku autoantigen, partial [Macaca mulatta]

Protein Classification

ATP-dependent DNA helicase 2 subunit KU80( domain architecture ID 10555821)

ATP-dependent DNA helicase 2 subunit KU80 is part of a single-stranded DNA-dependent, ATP-dependent helicase involved in non-homologous end joining (NHEJ) DNA double strand break repair

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ku_PK_bind pfam08785
Ku C terminal domain like; The non-homologous end joining (NHEJ) pathway is one method by ...
 1-112 3.00e-36

Ku C terminal domain like; The non-homologous end joining (NHEJ) pathway is one method by which double stranded breaks in chromosomal DNA are repaired. Ku is a component of a multi-protein complex that is involved in the NHEJ. Ku has affinity for DNA ends and recruits the DNA-dependent protein kinase catalytic subunit (DNA-PKcs). This domain is found at the C terminal of Ku which binds to DNA-PKcs.


:

Pssm-ID: 462604  Cd Length: 117  Bit Score: 120.38  E-value: 3.00e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38112388     1 AENFRVLVKQKK--ASFEEASNQLINHIEQFLDTNETP-YFMKSMDCIRAFREEAIKFSEEQRFNNFLKALREKVEIKQL 77
Cdd:pfam08785   3 VPDFKQLLARGDdvDAVEKAVKQMGNIIEDLVRDSFGDsNYDKALECLRALREECIEEEEPDLYNDFLRDLKKKLLEGDR 82

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 38112388    78 NHFWEIVVQDGITLITKEEASGSSVTADEAKKFLA 112
Cdd:pfam08785  83 REFWELVRKNKLGLITKDEAEDSDVTEEEAKEFLS 117
 
Name Accession Description Interval E-value
Ku_PK_bind pfam08785
Ku C terminal domain like; The non-homologous end joining (NHEJ) pathway is one method by ...
 1-112 3.00e-36

Ku C terminal domain like; The non-homologous end joining (NHEJ) pathway is one method by which double stranded breaks in chromosomal DNA are repaired. Ku is a component of a multi-protein complex that is involved in the NHEJ. Ku has affinity for DNA ends and recruits the DNA-dependent protein kinase catalytic subunit (DNA-PKcs). This domain is found at the C terminal of Ku which binds to DNA-PKcs.


Pssm-ID: 462604  Cd Length: 117  Bit Score: 120.38  E-value: 3.00e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38112388     1 AENFRVLVKQKK--ASFEEASNQLINHIEQFLDTNETP-YFMKSMDCIRAFREEAIKFSEEQRFNNFLKALREKVEIKQL 77
Cdd:pfam08785   3 VPDFKQLLARGDdvDAVEKAVKQMGNIIEDLVRDSFGDsNYDKALECLRALREECIEEEEPDLYNDFLRDLKKKLLEGDR 82

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 38112388    78 NHFWEIVVQDGITLITKEEASGSSVTADEAKKFLA 112
Cdd:pfam08785  83 REFWELVRKNKLGLITKDEAEDSDVTEEEAKEFLS 117
 
Name Accession Description Interval E-value
Ku_PK_bind pfam08785
Ku C terminal domain like; The non-homologous end joining (NHEJ) pathway is one method by ...
 1-112 3.00e-36

Ku C terminal domain like; The non-homologous end joining (NHEJ) pathway is one method by which double stranded breaks in chromosomal DNA are repaired. Ku is a component of a multi-protein complex that is involved in the NHEJ. Ku has affinity for DNA ends and recruits the DNA-dependent protein kinase catalytic subunit (DNA-PKcs). This domain is found at the C terminal of Ku which binds to DNA-PKcs.


Pssm-ID: 462604  Cd Length: 117  Bit Score: 120.38  E-value: 3.00e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38112388     1 AENFRVLVKQKK--ASFEEASNQLINHIEQFLDTNETP-YFMKSMDCIRAFREEAIKFSEEQRFNNFLKALREKVEIKQL 77
Cdd:pfam08785   3 VPDFKQLLARGDdvDAVEKAVKQMGNIIEDLVRDSFGDsNYDKALECLRALREECIEEEEPDLYNDFLRDLKKKLLEGDR 82

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 38112388    78 NHFWEIVVQDGITLITKEEASGSSVTADEAKKFLA 112
Cdd:pfam08785  83 REFWELVRKNKLGLITKDEAEDSDVTEEEAKEFLS 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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