transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily; TGF-beta superfamily consists of a large group of cell regulatory proteins, such as TFG-betas, Nodal, Activins/Inhibins, glial cell-line-derived neurotrophic factor (GDNF) family of ligands, bone morphogenetic proteins (BMPs), and growth and differentiation factors (GDFs). They play important roles in developmental and physiological processes in a variety of species, including invertebrates as well as vertebrates, through specific receptor complexes that are composed of type I and type II serine/threonine receptor kinases. The receptor kinases subsequently activate Smad proteins, which then propagate the signals into the nucleus to regulate target gene expression. Proteins from the TGF-beta superfamily are only active as homo- or heterodimer.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 37683095   1 VLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS 52
Cdd:cd19386  50 VLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS 101

transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-3 (TGF-beta-3) and similar proteins; TGF-beta-3 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is involved in embryogenesis and cell differentiation. It regulates molecules involved in cellular adhesion and extracellular matrix (ECM) formation during the process of palate development.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 37683095   1 VLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS 52
Cdd:cd19386  50 VLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS 101

Transforming growth factor beta like domain;

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 37683095     1 VLGLYNTLNPEASASPCCVPQDLEPLTILYYV-GRTPKVEQLSNMVVKSCKC 51
Cdd:pfam00019  51 LQSLLHSLKPANVPKPCCVPTKLSPLSVLYYDdEGNVVLKTYPDMVVESCGC 102

transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-3 (TGF-beta-3) and similar proteins; TGF-beta-3 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is involved in embryogenesis and cell differentiation. It regulates molecules involved in cellular adhesion and extracellular matrix (ECM) formation during the process of palate development.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 37683095   1 VLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS 52
Cdd:cd19386  50 VLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS 101

transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1), beta-2 (TGF-beta-2), beta-3 (TGF-beta-3) and similar proteins; The family includes TGF-beta-1, TGF-beta-2 and TGF-beta-3, which are polypeptide members of the transforming growth factor beta superfamily of cytokines. TGF-beta-1 is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation, and apoptosis. TGF-beta-2 is a secreted protein that performs many cellular functions and has a vital role during embryonic development. It can suppress the effects of interleukin-2 dependent T-cell growth. TGF-beta-3 is involved in embryogenesis and cell differentiation. It regulates molecules involved in cellular adhesion and extracellular matrix (ECM) formation during the process of palate development.

                       10        20        30        40        50
               ....*....|....*....|....*....|....*....|....*....|.
gi 37683095  1 VLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKC 51
Cdd:cd13753 47 VLQLYNRLNPVASAAPCCSPRELEPLTILYYDGRNPKIETLSNMIVTSCKC 97

Transforming growth factor-beta (TGF-beta) family; Family members are active as disulphide-linked homo- or heterodimers. TGFB is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 37683095      1 VLGLYNTLNPEASASPCCVPQDLEPLTILYYV-GRTPKVEQLSNMVVKSCKCS 52
Cdd:smart00204  50 VQTLVHLLGPNPVPKPCCVPTKLSPLSMLYYDdDGNVVLRNYPNMVVEECGCR 102

transforming growth factor beta (TGF-beta) like domain found in mammalian growth/differentiation factor 15 (GDF-15) and similar proteins; GDF-15, also termed macrophage inhibitory cytokine 1 (MIC-1), or NSAID-activated gene 1 protein (NAG-1), or NSAID-regulated gene 1 protein (NRG-1), or placental TGF-beta, or placental bone morphogenetic protein, or prostate differentiation factor, regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 37683095   6 NTLNPEASASPCCVPQDLEPLTILYYvGRTPKVEQ--LSNMVVKSCKCS 52
Cdd:cd19376  54 HRLNPGAVPAPCCVPSSYEPLTLLHY-DSDGKLTLteFDDMIVKDCHCA 101

transforming growth factor beta (TGF-beta) like domain found in the BMP/GDF family; The BMP/GDF family consists of bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and similar proteins. BMPs are a group of growth factors also known as cytokines and as metabologens. They induce the formation of bone and cartilage and functions as pivotal morphogenetic signals, orchestrating tissue architecture throughout the body. GDFs have functions predominantly in development.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 37683095   1 VLGLYNTLNPEASAS-PCCVPQDLEPLTILYYVG-RTPKVEQLSNMVVKSCKC 51
Cdd:cd13756  50 LQALLHSLNPKKSVPkPCCVPTKYSPLSVLYYDEdGNVVLKTYPDMVVEECGC 102

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 5 (GDF5), factor 6 (GDF6), factor 7 (GDF7) and similar proteins; The family includes GDF5, GDF6 and GDF7. GDF5, also termed bone morphogenetic protein 14 (BMP-14), or cartilage-derived morphogenetic protein 1 (CDMP-1), or lipopolysaccharide-associated protein 4 (LAP-4), or LPS-associated protein 4, or radotermin, is a growth factor involved in bone and cartilage formation. GDF6, also termed bone morphogenetic protein 13 (BMP-13), or growth/differentiation factor 16, is a growth factor that controls proliferation and cellular differentiation in the retina and bone formation. GDF7, also termed bone morphogenetic protein 12 (BMP-12), may play an active role in the motor area of the primate neocortex.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 37683095   4 LYNTLNPEASASPCCVPQDLEPLTILYY-VGRTPKVEQLSNMVVKSCKCS 52
Cdd:cd13766  53 LMNSMDPESTPPSCCVPTKLSPISILYIdSANNVVYKQYEDMVVESCGCR 102

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 8 (GDF8) and similar proteins; GDF8, also termed myostatin, acts specifically as a negative regulator of skeletal muscle growth.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 37683095   4 LYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVE-QLSNMVVKSCKCS 52
Cdd:cd19388  59 LVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYgKIPAMVVDRCGCS 108

transforming growth factor beta (TGF-beta) like domain found in Nodal (NODAL)-related proteins; NODAL is essential for mesoderm formation and axial patterning during embryonic development.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 37683095   3 GLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKC 51
Cdd:cd13759  54 SLLKLYQPDRVPLPCCVPTKLSPLSMLYYEHGEVVVRHHEDMIVEECGC 102

transforming growth factor beta (TGF-beta) like domain found in Drosophila melanogaster maverick and similar proteins; Maverick, also termed MAV, is a novel member of the TGF-beta superfamily in Drosophila. It's a bone morphogenetic protein (BMP)/TGF-beta related ligand.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 37683095  15 SPCCVPQDLEPLTILYYVGRTP---KVEQLSNMVVKSCKC 51
Cdd:cd13755  63 RPCCAPSKLESLEVLHYDESDSsklKVTKWKGMIVSECAC 102

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 8A (BMP-8A), 8B (BMP-8B) and similar proteins; BMP-8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis. BMP-8B, also termed BMP-8, or osteogenic protein 2 (OP-2), may act as secreted factor in cancer progression. It also plays an essential role in bone metabolism and can regulate thermogenesis and energy balance. Like BMP-8A, BMP-8B plays a role in spermatogenesis and placental development. Mutation in either of the genes encoding BMP-8A or BMP-8B causes postnatal depletion of spermatogonia in mice.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 37683095   4 LYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKV-EQLSNMVVKSCKC 51
Cdd:cd19398  56 LVHLMKPEAVPKACCAPTKLSATSVLYYDSNNNVIlKKHRNMVVKSCGC 104

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 11 (GDF11) and similar proteins; GDF11, also termed bone morphogenetic protein 11 (BMP-11), is a secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 37683095   4 LYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVE-QLSNMVVKSCKCS 52
Cdd:cd19389  60 LVQQANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYgKIPGMVVDRCGCS 109

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 6 (BMP-6) and similar proteins; BMP-6, also termed VG-1-related protein, or VG-1-R, or VGR-1, induces cartilage and bone formation.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 37683095   1 VLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKV-EQLSNMVVKSCKC 51
Cdd:cd19396  51 VQTLVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVIlKKYRNMVVRACGC 102

transforming growth factor beta (TGF-beta) like domain found in inhibin beta C chain (INHBC), inhibin beta E chain (INHBE) and similar proteins; The family includes INHBC and INHBE. INHBC, also termed activin beta-C chain, might play important roles in carcinogenesis. It may function as a negative regulator of liver growth. INHBE, also termed activin beta-E chain, is a possible insulin resistance-associated hepatokine with hepatic gene expression that positively correlated with insulin resistance and body mass index in humans. It also acts as a possible new marker for drug-induced endoplasmic reticulum stress.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 37683095   1 VLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVE-QLSNMVVKSCKCS 52
Cdd:cd19406  52 VLNLVKANNIATAVHSCCVPTARRPLSLLYFDRNSNIVKtDIPDMIVEACGCS 104

transforming growth factor beta (TGF-beta) like domain found in Drosophila melanogaster protein decapentaplegic (Dpp) and similar proteins; decapentaplegic (Dpp) and similar proteins Dpp, also termed as protein DPP-C, is required later in embryogenesis for dorsal closure and patterning of the hindgut. It also functions postembryonically as a long-range morphogen during imaginal disk development and is responsible for the progression of the morphogenetic furrow during eye development.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 37683095   1 VLGLYNTLNPEASASPCCVPQDLEPLTILyYVGRTPKV--EQLSNMVVKSCKC 51
Cdd:cd19392  57 VQTLVNSVDPQAVPKACCVPTELSSIAML-YVDEHDKVvlKNYQDMVVEGCGC 108

transforming growth factor beta (TGF-beta) like domain found in anti-dorsalizing morphogenetic protein (ADMP) and similar proteins; ADMP is a bone morphogenetic protein (BMP)-like transforming growth factor beta ligand, functions in the trunk organizer to antagonize head formation, thereby regulating organizer patterning. It negatively affects the formation of the organizer, although it is robustly expressed within the organizer itself. The organizer-promoting signal of ADMP is mediated by the activin A type I receptor, ACVR1 (also known as activin receptor-like kinase-2, ALK2).

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 37683095   1 VLGLYNTLN-PEASASPCCVPQDLEPLTILYYVGRTPKV-EQLSNMVVKSCKC 51
Cdd:cd13765  52 VQSIVHALKlAKGVEMPCCVPDKLYSISLLYFDDDENVVlKQYDDMVAASCGC 104

transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA) and similar proteins; INHBA, also termed activin beta-A chain, or erythroid differentiation protein (EDF), is a component of inhibin A, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 37683095   9 NPEASASPCCVPQDLEPLTILYYVGRTPKVEQ-LSNMVVKSCKCS 52
Cdd:cd19404  64 SPFANLKSCCVPTKLRAMSMLYYDDGQNIIKKdIQNMIVEECGCS 108

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 10 (BMP-10) and similar proteins; BMP-10 is required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. It inhibits endothelial cell migration and growth. It may reduce cell migration and cell matrix adhesion in breast cancer cell lines.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 37683095   4 LYNTLNPEASASPCCVPQDLEPLTILYY--VGRTPKVEQLSNMVVKSCKC 51
Cdd:cd19401  55 LVHLKNPQKASKACCVPTKLDPISILYLddAGVVTYKFKYEGMVVAECGC 104

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 3 (BMP-3) and similar proteins; BMP-3, also termed BMP-3A, or osteogenin, negatively regulates bone density. It antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.

                        10        20        30
                ....*....|....*....|....*....|....*..
gi 37683095  16 PCCVPQDLEPLTILYY-VGRTPKVEQLSNMVVKSCKC 51
Cdd:cd19393  73 PCCVPEKMSSLSILFFdENKNVVLKVYPNMTVESCAC 109