general transcription factor IIA, 2, 12kDa [Homo sapiens]
transcription initiation factor IIA subunit 2 family protein( domain architecture ID 1004649)
transcription initiation factor IIA (TFIIA) subunit 2 family protein is a component of TFIIA, part of the transcription machinery of RNA polymerase II that plays an important role in transcriptional activation
List of domain hits
Name | Accession | Description | Interval | E-value | |||
TOA2 super family | cl34913 | Transcription initiation factor IIA, gamma subunit [Transcription]; |
3-103 | 7.60e-28 | |||
Transcription initiation factor IIA, gamma subunit [Transcription]; The actual alignment was detected with superfamily member COG5123: Pssm-ID: 227452 [Multi-domain] Cd Length: 113 Bit Score: 98.10 E-value: 7.60e-28
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Name | Accession | Description | Interval | E-value | |||
TOA2 | COG5123 | Transcription initiation factor IIA, gamma subunit [Transcription]; |
3-103 | 7.60e-28 | |||
Transcription initiation factor IIA, gamma subunit [Transcription]; Pssm-ID: 227452 [Multi-domain] Cd Length: 113 Bit Score: 98.10 E-value: 7.60e-28
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TFIIA_gamma_N | pfam02268 | Transcription initiation factor IIA, gamma subunit, helical domain; Accurate transcription in ... |
3-48 | 3.10e-24 | |||
Transcription initiation factor IIA, gamma subunit, helical domain; Accurate transcription in vivo requires at least six general transcription initiation factors, in addition to RNA polymerase II. Transcription initiation factor IIA (TFIIA) is a multimeric protein which facilitates the binding of TFIID to the TATA box. The N-terminal domain of the gamma subunit is a 4 helix bundle. Pssm-ID: 460518 Cd Length: 46 Bit Score: 86.74 E-value: 3.10e-24
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TFIIA_gamma_C | cd10014 | Gamma subunit of transcription initiation factor IIA, C-terminal domain; Transcription factor ... |
56-101 | 5.83e-24 | |||
Gamma subunit of transcription initiation factor IIA, C-terminal domain; Transcription factor II A (TFIIA) is one of the general transcription factors for RNA polymerase II. TFIIA increases the affinity of the TATA-binding protein (TBP) for DNA, in order to assemble the initiation complex. TFIIA also functions as an activator during development and differentiation, and is involved in transcription from TATA-less promoters. TFIIA is composed of more than one subunit in various organisms. Mammalian TFIIA large subunits (TFIIA alpha and beta), and the smaller subunit (TFIIA gamma) form a heterotrimer. TFIIA alpha and beta are encoded by a single TFIIA_alpha_beta gene and post-translationally processed and cleaved. TOA1 and TOA2 are the two subunits of Yeast TFIIA which correspond to Mammalian TFIIA_alpha_beta and TFIIA gamma, respectively. TOA1 and TOA2 form a heterodimeric protein complex. The TFIIA gamma subunit is highly conserved between humans, Drosophila and yeast and it is required for TFIIA function. The C-terminal domain of the gamma (TFIIA_gamma_C) subunit forms a beta-barrel structure together with TFIIA beta. Pssm-ID: 199900 Cd Length: 47 Bit Score: 86.15 E-value: 5.83e-24
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Name | Accession | Description | Interval | E-value | |||
TOA2 | COG5123 | Transcription initiation factor IIA, gamma subunit [Transcription]; |
3-103 | 7.60e-28 | |||
Transcription initiation factor IIA, gamma subunit [Transcription]; Pssm-ID: 227452 [Multi-domain] Cd Length: 113 Bit Score: 98.10 E-value: 7.60e-28
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TFIIA_gamma_N | pfam02268 | Transcription initiation factor IIA, gamma subunit, helical domain; Accurate transcription in ... |
3-48 | 3.10e-24 | |||
Transcription initiation factor IIA, gamma subunit, helical domain; Accurate transcription in vivo requires at least six general transcription initiation factors, in addition to RNA polymerase II. Transcription initiation factor IIA (TFIIA) is a multimeric protein which facilitates the binding of TFIID to the TATA box. The N-terminal domain of the gamma subunit is a 4 helix bundle. Pssm-ID: 460518 Cd Length: 46 Bit Score: 86.74 E-value: 3.10e-24
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TFIIA_gamma_C | cd10014 | Gamma subunit of transcription initiation factor IIA, C-terminal domain; Transcription factor ... |
56-101 | 5.83e-24 | |||
Gamma subunit of transcription initiation factor IIA, C-terminal domain; Transcription factor II A (TFIIA) is one of the general transcription factors for RNA polymerase II. TFIIA increases the affinity of the TATA-binding protein (TBP) for DNA, in order to assemble the initiation complex. TFIIA also functions as an activator during development and differentiation, and is involved in transcription from TATA-less promoters. TFIIA is composed of more than one subunit in various organisms. Mammalian TFIIA large subunits (TFIIA alpha and beta), and the smaller subunit (TFIIA gamma) form a heterotrimer. TFIIA alpha and beta are encoded by a single TFIIA_alpha_beta gene and post-translationally processed and cleaved. TOA1 and TOA2 are the two subunits of Yeast TFIIA which correspond to Mammalian TFIIA_alpha_beta and TFIIA gamma, respectively. TOA1 and TOA2 form a heterodimeric protein complex. The TFIIA gamma subunit is highly conserved between humans, Drosophila and yeast and it is required for TFIIA function. The C-terminal domain of the gamma (TFIIA_gamma_C) subunit forms a beta-barrel structure together with TFIIA beta. Pssm-ID: 199900 Cd Length: 47 Bit Score: 86.15 E-value: 5.83e-24
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TFIIA_gamma_N | cd10145 | Gamma subunit of transcription initiation factor IIA, N-terminal helical domain; Transcription ... |
2-50 | 1.19e-23 | |||
Gamma subunit of transcription initiation factor IIA, N-terminal helical domain; Transcription factor II A (TFIIA) is one of the general transcription factors for RNA polymerase II. TFIIA increases the affinity of the TATA-binding protein (TBP) for DNA, in order to assemble the initiation complex. TFIIA also functions as an activator during development and differentiation, and is involved in transcription from TATA-less promoters. TFIIA is composed of more than one subunit in various organisms. Mammalian TFIIA large subunits (TFIIA alpha and beta), and the smaller subunit (TFIIA gamma) form a heterotrimer. TFIIA alpha and beta are encoded by a single TFIIA_alpha_beta gene and post-translationally processed and cleaved. TOA1 and TOA2 are the two subunits of Yeast TFIIA which correspond to Mammalian TFIIA_alpha_beta and TFIIA gamma, respectively. TOA1 and TOA2 form a heterodimeric protein complex. The TFIIA gamma subunit is highly conserved between humans, Drosophila and yeast and it is required for TFIIA function. The N-terminal domain of the gamma subunit forms a 4-helix bundle together with the alpha subunit. Pssm-ID: 199901 Cd Length: 49 Bit Score: 85.31 E-value: 1.19e-23
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TFIIA_gamma_C | pfam02751 | Transcription initiation factor IIA, gamma subunit; Accurate transcription in vivo requires at ... |
59-100 | 4.72e-23 | |||
Transcription initiation factor IIA, gamma subunit; Accurate transcription in vivo requires at least six general transcription initiation factors, in addition to RNA polymerase II. Transcription initiation factor IIA (TFIIA) is a multimeric protein which facilitates the binding of TFIID to the TATA box. The C-terminal domain of the gamma subunit is a 12 stranded beta-barrel. Pssm-ID: 460675 Cd Length: 43 Bit Score: 83.74 E-value: 4.72e-23
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Blast search parameters | ||||
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