Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31455594 165 QIEENSNANTLVMKLNATDADEPNnlNSMIAFKIIrqEPSDSPMFTINRKTGEIRTmNNFLDREQYSQYSLVVRGSdrDG 244
Cdd:cd11304   5 SVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIV--SGNEDGLFSIDPSTGEITT-AKPLDREEQSSYTLTVTAT--DG 77

                        90       100
                ....*....|....*....|.
gi 31455594 245 GADGMSAESECSITILDVNDN 265
Cdd:cd11304  78 GGPPLSSTATVTITVLDVNDN 98

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31455594 273 SYDITIEENT-LHSQLLQIRVIDLDEEfsDNWKAIIFFISGNEGNWFEIemNERTnvGTLKVVKPLDYEAVKNLQLCIGV 351
Cdd:cd11304   1 SYEVSVPENApPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                        90       100
                ....*....|....*....|....*...
gi 31455594 352 RNVAEFHQSiisqyrlTVTLITVTVLNV 379
Cdd:cd11304  75 TDGGGPPLS-------STATVTITVLDV 95

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31455594 165 QIEENSNANTLVMKLNATDADEPNnlNSMIAFKIIrqEPSDSPMFTINRKTGEIRTmNNFLDREQYSQYSLVVRGSdrDG 244
Cdd:cd11304   5 SVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIV--SGNEDGLFSIDPSTGEITT-AKPLDREEQSSYTLTVTAT--DG 77

                        90       100
                ....*....|....*....|.
gi 31455594 245 GADGMSAESECSITILDVNDN 265
Cdd:cd11304  78 GGPPLSSTATVTITVLDVNDN 98

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31455594    180 NATDADEPNNlnSMIAFKIIRQEPSDspMFTINRKTGEIRTMNNfLDREQYSQYSLVVRGsdRDGGADGMSAESECSITI 259
Cdd:smart00112   1 SATDADSGEN--GKVTYSILSGNDDG--LFSIDPETGEITTTKP-LDREEQPEYTLTVEA--TDGGGPPLSSTATVTITV 73

                   ....*...
gi 31455594    260 LDVNDNIP 267
Cdd:smart00112  74 LDVNDNAP 81

Cadherin domain;

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31455594    54 FAAACREGE-DNSKRNPIAKIHSDCAANQPVTYRISGvgidQPPYGIFIINQKTGEINITSIVDREVTPFFIIYCRALNA 132
Cdd:pfam00028   1 YSASVPENApVGTEVLTVTATDPDLGPNGRIFYSILG----GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*
gi 31455594   133 QGQDLENPLELRVRV 147
Cdd:pfam00028  77 GGPPLSSTATVTITV 91

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31455594 273 SYDITIEENT-LHSQLLQIRVIDLDEEfsDNWKAIIFFISGNEGNWFEIemNERTnvGTLKVVKPLDYEAVKNLQLCIGV 351
Cdd:cd11304   1 SYEVSVPENApPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                        90       100
                ....*....|....*....|....*...
gi 31455594 352 RNVAEFHQSiisqyrlTVTLITVTVLNV 379
Cdd:cd11304  75 TDGGGPPLS-------STATVTITVLDV 95

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 31455594   676 ADEDEGRPSNDCLLIYDIEGVGSPAG---SVGCCSFIEDLDESFLDTLGPKFKKLADI 730
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGslsSLESSTSDSDQDYDYLSDWGPRFKKLAEL 58

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31455594 165 QIEENSNANTLVMKLNATDADEPNnlNSMIAFKIIrqEPSDSPMFTINRKTGEIRTmNNFLDREQYSQYSLVVRGSdrDG 244
Cdd:cd11304   5 SVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIV--SGNEDGLFSIDPSTGEITT-AKPLDREEQSSYTLTVTAT--DG 77

                        90       100
                ....*....|....*....|.
gi 31455594 245 GADGMSAESECSITILDVNDN 265
Cdd:cd11304  78 GGPPLSSTATVTITVLDVNDN 98

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31455594    180 NATDADEPNNlnSMIAFKIIRQEPSDspMFTINRKTGEIRTMNNfLDREQYSQYSLVVRGsdRDGGADGMSAESECSITI 259
Cdd:smart00112   1 SATDADSGEN--GKVTYSILSGNDDG--LFSIDPETGEITTTKP-LDREEQPEYTLTVEA--TDGGGPPLSSTATVTITV 73

                   ....*...
gi 31455594    260 LDVNDNIP 267
Cdd:smart00112  74 LDVNDNAP 81

Cadherin domain;

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31455594    54 FAAACREGE-DNSKRNPIAKIHSDCAANQPVTYRISGvgidQPPYGIFIINQKTGEINITSIVDREVTPFFIIYCRALNA 132
Cdd:pfam00028   1 YSASVPENApVGTEVLTVTATDPDLGPNGRIFYSILG----GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*
gi 31455594   133 QGQDLENPLELRVRV 147
Cdd:pfam00028  77 GGPPLSSTATVTITV 91

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31455594 273 SYDITIEENT-LHSQLLQIRVIDLDEEfsDNWKAIIFFISGNEGNWFEIemNERTnvGTLKVVKPLDYEAVKNLQLCIGV 351
Cdd:cd11304   1 SYEVSVPENApPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                        90       100
                ....*....|....*....|....*...
gi 31455594 352 RNVAEFHQSiisqyrlTVTLITVTVLNV 379
Cdd:cd11304  75 TDGGGPPLS-------STATVTITVLDV 95

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 31455594   676 ADEDEGRPSNDCLLIYDIEGVGSPAG---SVGCCSFIEDLDESFLDTLGPKFKKLADI 730
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGslsSLESSTSDSDQDYDYLSDWGPRFKKLAEL 58

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31455594  57 ACREGEDNSKRnpIAKIHSDCAANQPVTYRISGVGIDQPPyGIFIINQKTGEINITSIVDREVTPFFIIYCRALNAQGQD 136
Cdd:cd00031   5 SAVEGRSRGSF--RVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANV 81

                        90
                ....*....|....*..
gi 31455594 137 LENPLELRVRVMDINDN 153
Cdd:cd00031  82 PQTSSVFSIEVYDENDN 98