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Conserved domains on  [gi|28416565|gb|AAO42813|]
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At1g78130 [Arabidopsis thaliana]

Protein Classification

spinster family MFS transporter( domain architecture ID 13023647)

spinster family major facilitator superfamily (MFS) transporter may function as a sphingolipid transporter that plays a central role in endosome and/or lysosome storage

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0006869
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1.49

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 8-434 1.51e-74

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 240.60  E-value: 1.51e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565   8 LLLVNLAGIMERADESLLPGVYKEVGLALHTDPTGLGSLTLLRSMVQAACYPLAAYMAIRHNRAHVIALGAFLWSAATFL 87
Cdd:cd17328   1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  88 VAFSSTFFQVAVSRALNGIGLALVAPAIQSLVADSTDDANRGTAFGWLQLTANIGSILGGLCSVLIAPLTfmgiPGWRVA 167
Cdd:cd17328  81 SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQAT----GGWRWA 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 168 FHIVGVISVIVGVLVRVFANDPHFvKDGVDVSNQPGSRKPFCTEVKDLvreadtvIKIRSFQIIVAQGVTGSFPWSALSF 247
Cdd:cd17328 157 FRVTGVLGVLLAILLLLFVREPPR-GAAEGGVMAKSTATSFLADLKAL-------AKNPSFILSTLGFTAVSFVTGALAF 228

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 248 APMWLELIGFS--HGKTAFLMGLFVAASSLGGLFGGKMGDFLSTRL---PNSGRIILAQISSASAIPLAAILLLVlpddp 322
Cdd:cd17328 229 WAPTFFLRAFGvgDLSSADVGLIFGAITCIAGVLGVLLGGILADRLrrkTPRADPLVCAVGLLAAAPFLFLALVL----- 303

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 323 stAAIHGLILVLLGLFVSWNAPATNNPIFA---EIVPEKSRTSVYALDKSFESILSSFAPPIVGILAQHVYGYKPipegs 399
Cdd:cd17328 304 --ALSNLLLAWVLLFLGEFLLSLNWAPVFAillYVVIPTRRSTASAIQILLSHLLGDAGSPYLIGLISDLLRQNK----- 376

                       410       420       430
                ....*....|....*....|....*....|....*
gi 28416565 400 srsteiATDRENAASLAKALYTSIGLPMAACCFIY 434
Cdd:cd17328 377 ------DSPLAEAASLQYALLLCSFVLVLGGFFFL 405
 
Name Accession Description Interval E-value
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 8-434 1.51e-74

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 240.60  E-value: 1.51e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565   8 LLLVNLAGIMERADESLLPGVYKEVGLALHTDPTGLGSLTLLRSMVQAACYPLAAYMAIRHNRAHVIALGAFLWSAATFL 87
Cdd:cd17328   1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  88 VAFSSTFFQVAVSRALNGIGLALVAPAIQSLVADSTDDANRGTAFGWLQLTANIGSILGGLCSVLIAPLTfmgiPGWRVA 167
Cdd:cd17328  81 SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQAT----GGWRWA 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 168 FHIVGVISVIVGVLVRVFANDPHFvKDGVDVSNQPGSRKPFCTEVKDLvreadtvIKIRSFQIIVAQGVTGSFPWSALSF 247
Cdd:cd17328 157 FRVTGVLGVLLAILLLLFVREPPR-GAAEGGVMAKSTATSFLADLKAL-------AKNPSFILSTLGFTAVSFVTGALAF 228

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 248 APMWLELIGFS--HGKTAFLMGLFVAASSLGGLFGGKMGDFLSTRL---PNSGRIILAQISSASAIPLAAILLLVlpddp 322
Cdd:cd17328 229 WAPTFFLRAFGvgDLSSADVGLIFGAITCIAGVLGVLLGGILADRLrrkTPRADPLVCAVGLLAAAPFLFLALVL----- 303

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 323 stAAIHGLILVLLGLFVSWNAPATNNPIFA---EIVPEKSRTSVYALDKSFESILSSFAPPIVGILAQHVYGYKPipegs 399
Cdd:cd17328 304 --ALSNLLLAWVLLFLGEFLLSLNWAPVFAillYVVIPTRRSTASAIQILLSHLLGDAGSPYLIGLISDLLRQNK----- 376

                       410       420       430
                ....*....|....*....|....*....|....*
gi 28416565 400 srsteiATDRENAASLAKALYTSIGLPMAACCFIY 434
Cdd:cd17328 377 ------DSPLAEAASLQYALLLCSFVLVLGGFFFL 405
MFS_1 pfam07690
Major Facilitator Superfamily;
13-379 2.57e-26

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 109.43  E-value: 2.57e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565    13 LAGIMERADESLLPGVYKE-VGLALHTDPTGLGSLTLLRSMVQAACYPLAAYMAIRHNRAHVIALGAFLWSAATFLVAFS 91
Cdd:pfam07690   3 LAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565    92 STFFQVAVSRALNGIGLALVAPAIQSLVADSTDDANRGTAFGWLQLTANIGSILGGLCSVLIApltfmGIPGWRVAFHIV 171
Cdd:pfam07690  83 SSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA-----SLFGWRAAFLIL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565   172 GVISVIVGVLVRVFANDPhfvkDGVDVSNQPGSRKPFCTEVKDLVREadtvikiRSFQIIVAQGVTGSFPWSALSFAPMW 251
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPP----ESKRPKPAEEARLSLIVAWKALLRD-------PVLWLLLALLLFGFAFFGLLTYLPLY 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565   252 LELIGFSHGKTAFLMGLFVAASSLGGLFGGKmgdfLSTRLPNSGRIILaqissASAIPLAAILLLVLPDDPSTAAIHGLI 331
Cdd:pfam07690 227 QEVLGLSALLAGLLLGLGGLLGAIGRLLLGR----LSDRLGRRRRLLL-----ALLLLILAALGLLLLSLTLSSLWLLLA 297

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 28416565   332 LVLLGLFVSWNAPATNNpIFAEIVPEKSRTSVYALDKSFESILSSFAP 379
Cdd:pfam07690 298 LLLLGFGFGLVFPALNA-LVSDLAPKEERGTASGLYNTAGSLGGALGP 344
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
6-395 2.06e-25

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 107.26  E-value: 2.06e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565   6 MTLLLVNLAGIMERADESLLPGVYKEVGLALHTDPTGLGSLTLLRSMVQAACYPLAAYMAIRHNRAHVIALGAFLWSAAT 85
Cdd:COG2271  10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  86 FLVAFSSTFFQVAVSRALNGIGLALVAPAIQSLVADSTDDANRGTAFGWLQLTANIGSILGGLCSVLIAPLTfmgipGWR 165
Cdd:COG2271  90 LLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF-----GWR 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 166 VAFHIVGVISVIVGVLvrvfandphfvkdgvdvsnqpgsrkpfctevkdlvreadtvikirSFQIIVAQGVTGSFPWSA- 244
Cdd:COG2271 165 AAFLILGLPGLLLALL---------------------------------------------RFWLLALAYFLVYFALYGf 199

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 245 LSFAPMWL-ELIGFSHGKTAFLMGLFVAASSLGGLFGGkmgdFLSTRLPNSGRIILAqisSASAIPLAAILLLVLPDDPS 323
Cdd:COG2271 200 LTWLPTYLvEVRGLSLAQAGLLLSLPFLAGIVGSLLGG----WLSDRLGRRRKLVLA---IGLLLAALALLLLALLPSPA 272

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 28416565 324 TAAIhglILVLLGLFVSWNAPATnNPIFAEIVPEKSRTSVYALDKSFESILSSFAPPIVGILAQHvYGYKPI 395
Cdd:COG2271 273 LAIA---LLFLAGFGLGGAFGLL-WALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDA-TGYQAA 339
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 43-339 2.33e-10

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 62.37  E-value: 2.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565    43 LGSLTLLRSMVQAAcypLAAYMAIRHNRAHVIALGAFLWSAATFLVAFSSTFFQVAVSRALNGIGLALVAPAIQSLVADS 122
Cdd:TIGR00895  57 LFSAGLIGMAFGAL---FFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEY 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565   123 TDDANRGTAFGWLQLTANIGSILGGLCSVLIAPLTfmgipGWRVAFHIVGVISVIVGVLVRVFANDPhfvKDGVDVSNQP 202
Cdd:TIGR00895 134 APKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVF-----GWRSLFYVGGIAPLLLLLLLMRFLPES---IDFLVSKRPE 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565   203 GSRKPFCTEVKDLVREADTVI--------KIRSFQIIVAQG----------VTGSFPWSALSFAPMWLELI----GFSHG 260
Cdd:TIGR00895 206 TVRRIVNAIAPQMQAEAQSALpeqkstqgTKRSVFKALFQGktaritvllwLLYFMLLVGVYFLTNWLPKLmvelGFSLS 285

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 28416565   261 KTAFLMGLFVAASSLGGLFGGKMGDFLSTRLPNSGRIilaqissasaipLAAILLLVLPDDPSTAAIHGLILVLLGLFV 339
Cdd:TIGR00895 286 LAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLL------------LGAVFAVLVGSTLFSPTLLLLLGAIAGFFV 352
 
Name Accession Description Interval E-value
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 8-434 1.51e-74

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 240.60  E-value: 1.51e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565   8 LLLVNLAGIMERADESLLPGVYKEVGLALHTDPTGLGSLTLLRSMVQAACYPLAAYMAIRHNRAHVIALGAFLWSAATFL 87
Cdd:cd17328   1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  88 VAFSSTFFQVAVSRALNGIGLALVAPAIQSLVADSTDDANRGTAFGWLQLTANIGSILGGLCSVLIAPLTfmgiPGWRVA 167
Cdd:cd17328  81 SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQAT----GGWRWA 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 168 FHIVGVISVIVGVLVRVFANDPHFvKDGVDVSNQPGSRKPFCTEVKDLvreadtvIKIRSFQIIVAQGVTGSFPWSALSF 247
Cdd:cd17328 157 FRVTGVLGVLLAILLLLFVREPPR-GAAEGGVMAKSTATSFLADLKAL-------AKNPSFILSTLGFTAVSFVTGALAF 228

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 248 APMWLELIGFS--HGKTAFLMGLFVAASSLGGLFGGKMGDFLSTRL---PNSGRIILAQISSASAIPLAAILLLVlpddp 322
Cdd:cd17328 229 WAPTFFLRAFGvgDLSSADVGLIFGAITCIAGVLGVLLGGILADRLrrkTPRADPLVCAVGLLAAAPFLFLALVL----- 303

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 323 stAAIHGLILVLLGLFVSWNAPATNNPIFA---EIVPEKSRTSVYALDKSFESILSSFAPPIVGILAQHVYGYKPipegs 399
Cdd:cd17328 304 --ALSNLLLAWVLLFLGEFLLSLNWAPVFAillYVVIPTRRSTASAIQILLSHLLGDAGSPYLIGLISDLLRQNK----- 376

                       410       420       430
                ....*....|....*....|....*....|....*
gi 28416565 400 srsteiATDRENAASLAKALYTSIGLPMAACCFIY 434
Cdd:cd17328 377 ------DSPLAEAASLQYALLLCSFVLVLGGFFFL 405
MFS_1 pfam07690
Major Facilitator Superfamily;
13-379 2.57e-26

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 109.43  E-value: 2.57e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565    13 LAGIMERADESLLPGVYKE-VGLALHTDPTGLGSLTLLRSMVQAACYPLAAYMAIRHNRAHVIALGAFLWSAATFLVAFS 91
Cdd:pfam07690   3 LAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565    92 STFFQVAVSRALNGIGLALVAPAIQSLVADSTDDANRGTAFGWLQLTANIGSILGGLCSVLIApltfmGIPGWRVAFHIV 171
Cdd:pfam07690  83 SSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA-----SLFGWRAAFLIL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565   172 GVISVIVGVLVRVFANDPhfvkDGVDVSNQPGSRKPFCTEVKDLVREadtvikiRSFQIIVAQGVTGSFPWSALSFAPMW 251
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPP----ESKRPKPAEEARLSLIVAWKALLRD-------PVLWLLLALLLFGFAFFGLLTYLPLY 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565   252 LELIGFSHGKTAFLMGLFVAASSLGGLFGGKmgdfLSTRLPNSGRIILaqissASAIPLAAILLLVLPDDPSTAAIHGLI 331
Cdd:pfam07690 227 QEVLGLSALLAGLLLGLGGLLGAIGRLLLGR----LSDRLGRRRRLLL-----ALLLLILAALGLLLLSLTLSSLWLLLA 297

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 28416565   332 LVLLGLFVSWNAPATNNpIFAEIVPEKSRTSVYALDKSFESILSSFAP 379
Cdd:pfam07690 298 LLLLGFGFGLVFPALNA-LVSDLAPKEERGTASGLYNTAGSLGGALGP 344
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
6-395 2.06e-25

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 107.26  E-value: 2.06e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565   6 MTLLLVNLAGIMERADESLLPGVYKEVGLALHTDPTGLGSLTLLRSMVQAACYPLAAYMAIRHNRAHVIALGAFLWSAAT 85
Cdd:COG2271  10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  86 FLVAFSSTFFQVAVSRALNGIGLALVAPAIQSLVADSTDDANRGTAFGWLQLTANIGSILGGLCSVLIAPLTfmgipGWR 165
Cdd:COG2271  90 LLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF-----GWR 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 166 VAFHIVGVISVIVGVLvrvfandphfvkdgvdvsnqpgsrkpfctevkdlvreadtvikirSFQIIVAQGVTGSFPWSA- 244
Cdd:COG2271 165 AAFLILGLPGLLLALL---------------------------------------------RFWLLALAYFLVYFALYGf 199

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 245 LSFAPMWL-ELIGFSHGKTAFLMGLFVAASSLGGLFGGkmgdFLSTRLPNSGRIILAqisSASAIPLAAILLLVLPDDPS 323
Cdd:COG2271 200 LTWLPTYLvEVRGLSLAQAGLLLSLPFLAGIVGSLLGG----WLSDRLGRRRKLVLA---IGLLLAALALLLLALLPSPA 272

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 28416565 324 TAAIhglILVLLGLFVSWNAPATnNPIFAEIVPEKSRTSVYALDKSFESILSSFAPPIVGILAQHvYGYKPI 395
Cdd:COG2271 273 LAIA---LLFLAGFGLGGAFGLL-WALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDA-TGYQAA 339
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
6-366 5.83e-24

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 102.74  E-value: 5.83e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565   6 MTLLLVNLAGIMERADESLLPGVYKEVGLALHTDPTGLGSLTLLRSMVQAACYPLAAYMAIRHNRAHVIALGAFLWSAAT 85
Cdd:COG2814  10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  86 FLVAFSSTFFQVAVSRALNGIGLALVAPAIQSLVADSTDDANRGTAFGWLQLTANIGSILGGLCSVLIAPLTfmgipGWR 165
Cdd:COG2814  90 LLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF-----GWR 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 166 VAFHIVGVISVIVGVLVRVFANDPHfvkdgvdvsnqPGSRKPFCTEVKDLVREADTVIkirsfqIIVAQGVTGSFPWSAL 245
Cdd:COG2814 165 WVFLVNAVLALLALLLLLRLLPESR-----------PAARARLRGSLRELLRRPRLLL------LLLLAFLLGFGFFALF 227

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 246 SFAPMWL-ELIGFSHGKTAFLMGLFVAASSLGGLFGGKMGDFLSTRlpnsgRIILAqissASAIPLAAILLLVLPDDPST 324
Cdd:COG2814 228 TYLPLYLqEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRR-----RLLLI----GLLLLALGLLLLALAGSLWL 298

                       330       340       350       360
                ....*....|....*....|....*....|....*....|..
gi 28416565 325 AAIhglILVLLGLFVSWNAPATNNpIFAEIVPEKSRTSVYAL 366
Cdd:COG2814 299 LLL---ALFLLGFGFGLLFPLLQA-LVAELAPPEARGRASGL 336
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 36-389 7.31e-22

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 96.88  E-value: 7.31e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  36 LHTDPTGLGSLTLLRSMVQAACYPLAAYMAIRHNRAHVIALGAFLWSAATFLVAFSSTFFQVAVSRALNGIGLALVAPAI 115
Cdd:cd17325  26 LGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAA 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 116 QSLVADSTDDANRGTAFGWLQLTANIGSILG-GLCSVLIApltfmgIPGWRVAFHIVGVISVIVGVLVRVFANDPHFVKD 194
Cdd:cd17325 106 MALIADIAPPEERGRAMGIFSSAIGLGFLIGpLLGGLLAD------ALGYRAPFLVCAALALLALVLALLLLPEPRPPPN 179

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 195 GVDVSNQPGSRKPFctevkdlvreadTVIKIRSFQIIVAQGVTGSFPWSAL-SFAPMWL-ELIGFSHGKTAFLMGLFVAA 272
Cdd:cd17325 180 KRAVSAARLRSGLR------------LLLRDRRLLALFLAIFVLAFAFGALePFLPLYAaELGGLSPAQIGLLFGAQGLA 247

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 273 SSLGGLFGGKMGDFLSTRLPnsgrIILAQISSASAIPLAAIlllvlpddPSTAAIHGLILVLLGLFVSWNAPATnNPIFA 352
Cdd:cd17325 248 SALSQPPAGKLSDRIGRKPL----ILIGLLLSAVALLLLPL--------ATSFWLLLLLLALLGLGLGLVFPAT-LALLA 314

                       330       340       350
                ....*....|....*....|....*....|....*..
gi 28416565 353 EIVPEKSRTSVYALDKSFESILSSFAPPIVGILAQHV 389
Cdd:cd17325 315 DIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAF 351
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 13-392 2.10e-20

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 92.87  E-value: 2.10e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  13 LAGIMERADESLLPGVYKEVGLALHTDPTGLGSLTLLRSMVQAACYPLAAYMAIRHNRAHVIALGAFLWSAATFLVAFSS 92
Cdd:cd06174   3 LGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAP 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  93 TFFQVAVSRALNGIGLALVAPAIQSLVADSTDDANRGTAFGWLQLTANIGSILGGLcsvLIAPLTFMGIPGWRVAFHIVG 172
Cdd:cd06174  83 SFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPL---LGGILASSLGFGWRAVFLIAA 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 173 VISVIVGVLVRVFANDPHFvkdgvdvsnqPGSRKPFCTEVKDLVREADTVIKIRSFQIIVAQGVTGSFPWSALS--FAPM 250
Cdd:cd06174 160 ALALLAAILLLLVVPDPPE----------SARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFStlLPLF 229

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 251 WLELIGFSHGKTAFLMGLFVAASSLGGLFGGKMGDFLSTRLPnsgrIILAQIssasaipLAAILLLVLPDDPSTAAIHGL 330
Cdd:cd06174 230 LLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKP----LLLIGL-------LLMALGLALLLLAPSLLLLLL 298

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 28416565 331 ILVLLGLFVSWNAPATNNpIFAEIVPEKSRTSVYALDKSFESILSSFAPPIVGILAQHVYGY 392
Cdd:cd06174 299 LLLLLGFGLGGLLPLSFA-LIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGL 359
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
35-394 1.89e-16

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 81.08  E-value: 1.89e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  35 ALHTDPTGLGSLTLLRSMVQAACYPLAAYMAIRHNRAHVIALGAFLWSAATFLVAFSSTFFQVAVSRALNGIGLALVAPA 114
Cdd:COG2223  34 EFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAV 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 115 IQSLVADSTDDANRGTAFGWLQLTANIGSILGGlcsvLIAPLtFMGIPGWRVAFHIVGVISVIVGVLVRVFANDPhfvkd 194
Cdd:COG2223 114 GIALVSKWFPPDRRGLALGLAAGGGNLGAAVAA----FLAPL-LIAAFGWRNAFLILGILLLVVAVLAWLFLRDP----- 183

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 195 gvdvsnqPGSRKPfctEVKDLVREADTVIKIRSFQIIVAQGVTGSFPWSALS--FAPMWLELIGFSHGKTAFLMGLFVAA 272
Cdd:COG2223 184 -------PAGAAA---AAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSswLPPYLVDQFGLSAATAGLLAALFALL 253

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 273 SSLGGLFGGkmgdFLSTRLpnsGRIILAQISSASAIplAAILLLVLPDDPSTAAIhGLILVLLGLFVSWNAPATnnPIFA 352
Cdd:COG2223 254 GALGRPLGG----WLSDRI---GGRRVLLIVFALMA--LGLLLLALALGSLWLFL-VLFLLLGLALGGGNGAVF--ALVP 321

                       330       340       350       360
                ....*....|....*....|....*....|....*....|..
gi 28416565 353 EIVPEKSRTSVYALDKSFESILSSFAPPIVGILAQHVYGYKP 394
Cdd:COG2223 322 DIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTA 363
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 63-392 1.02e-14

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 75.33  E-value: 1.02e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  63 YMAIRHNRAHVIALGAFLWSAATFLVAFSSTFFQVAVSRALNGIGLALVAPAIQSLVADSTDDANRGTAFGWLQLTANIG 142
Cdd:cd17316  58 YLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALG 137

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 143 SILGGLCSVLIAPLtFMGIPGWRVAFhivgvISVIVGVLVRVFandphfvkdgvdvsnqpgsrkpfctevkdlvreadtv 222
Cdd:cd17316 138 ALLAALVASLLIPL-LSGDWGWRILF-----LIGALPALLALL------------------------------------- 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 223 IKIRSFQIIVAQGVTGSFPWSALSFAPMWLELI-GFSHGKTAFLMGLFVAASSLGGLFGGKMGDFLstrlpnsGRIILAQ 301
Cdd:cd17316 175 LRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVlGLSPATSSLYLLLISLGALVGALIAGLLSDRI-------GRKKTLV 247

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 302 ISSASAIPLAAILLLVLPDDPSTAAIHGLILVLLGLFVSWNAPAtnnpIFAEIVPEKSRTSVYALDKSFESILSSFAPPI 381
Cdd:cd17316 248 IGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYA----YLAELFPTEVRATGVGLSYNLGRLGGGGAPPL 323

                       330
                ....*....|.
gi 28416565 382 VGILAQHVYGY 392
Cdd:cd17316 324 IALLLASTGGT 334
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 7-287 5.44e-12

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 66.37  E-value: 5.44e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565   7 TLLLVNLAGIMERADESLLPGVYKEVGLALHTDPTGLGSLTLLRSMVQAACYPLAAYMAIRHNRAHVIALGAFLWSAATF 86
Cdd:COG0477  15 ALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASL 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  87 LVAFSSTFFQVAVSRALNGIGLALVAPAIQSLVADSTDDANRGTAFGWLQLTANIGSILGGLCSVLIAPLTfmgipGWRV 166
Cdd:COG0477  95 LCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAAL-----GWRW 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 167 AFhIVGVISVIVGVLVRVFANDPHFVKDGVDVSNQPGSRKPFCTEVKDLVREADTVIKIRSFQIIVAQGVTGSFPWSALS 246
Cdd:COG0477 170 IF-LINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLL 248

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 28416565 247 FAPMWLELIGFSHGKTAFLMGLFVAASSLGGLFGGKMGDFL 287
Cdd:COG0477 249 ALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLL 289
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 43-389 1.10e-11

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 66.17  E-value: 1.10e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  43 LGSLTLLRSMVQAAcypLAAYMAIRHNRAHVIALGAFLWSAATFLVAFSSTFFQVAVSRALNGIGLALVAPAIQSLVADS 122
Cdd:cd17371  39 LGTVTLAGGAIGGI---LGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEY 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 123 TDDANRGTAFGWLQLTANIGSILGGLCSVLIAPLTFMGIpGWRVAFhIVGVISVIVGVLVRVFANDPHfvkdgvdvSNQP 202
Cdd:cd17371 116 VPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEI-AWRVLF-LLGALPALLVLFIRRFVKEPP--------QWQA 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 203 GSRKPFCTEVKDLVREADTVIKIRSFQII--VAQGVTGSFpWSALSFAPMWLELI-GFSHGKTAFLMGLFVAASSLGGLF 279
Cdd:cd17371 186 ARAARRHFADRPSLRELFSPPLLRTTLLAslLATGALGGY-YGITTWLPSYLTGErGLSFEGSAGYLVVTILGGFLGYLA 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 280 GGKMGDFLSTRLpnsgRIILAQISSASAIPlaaiLLLVLPDDPSTAAIhglILVLLGLFVSwNAPATNNPIFAEIVPEKS 359
Cdd:cd17371 265 GGFLADRIGRRN----NFALFALGSAISIL----LYFFLPLSPTLILI---LGFPLGFFAS-GPFSGMGAYLTELFPTAV 332

                       330       340       350
                ....*....|....*....|....*....|
gi 28416565 360 RTSVYALDKSFESILSSFAPPIVGILAQHV 389
Cdd:cd17371 333 RATAQGFCYNVGRIIGALFPFLVGFLATSG 362
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 22-186 9.43e-11

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 63.36  E-value: 9.43e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  22 ESLLPGVYKEVGLAlhtDPTGLGSLTLLRSMVQAACYPLAAYMAIRHNRAHVIALGAFLWSAATFLVAFSSTFFQVAVSR 101
Cdd:cd17325 219 EPFLPLYAAELGGL---SPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLL 295

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 102 ALNGIGLALVAPAIQSLVADSTDDANRGTAFGWLQLTANIGSILGGLCSVLIAPLTfmgipGWRVAFHIVGVISVIVGVL 181
Cdd:cd17325 296 ALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAF-----GFATPFLAAAALLLLAAVL 370


                ....*
gi 28416565 182 VRVFA 186
Cdd:cd17325 371 FLLLR 375
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 43-339 2.33e-10

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 62.37  E-value: 2.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565    43 LGSLTLLRSMVQAAcypLAAYMAIRHNRAHVIALGAFLWSAATFLVAFSSTFFQVAVSRALNGIGLALVAPAIQSLVADS 122
Cdd:TIGR00895  57 LFSAGLIGMAFGAL---FFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEY 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565   123 TDDANRGTAFGWLQLTANIGSILGGLCSVLIAPLTfmgipGWRVAFHIVGVISVIVGVLVRVFANDPhfvKDGVDVSNQP 202
Cdd:TIGR00895 134 APKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVF-----GWRSLFYVGGIAPLLLLLLLMRFLPES---IDFLVSKRPE 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565   203 GSRKPFCTEVKDLVREADTVI--------KIRSFQIIVAQG----------VTGSFPWSALSFAPMWLELI----GFSHG 260
Cdd:TIGR00895 206 TVRRIVNAIAPQMQAEAQSALpeqkstqgTKRSVFKALFQGktaritvllwLLYFMLLVGVYFLTNWLPKLmvelGFSLS 285

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 28416565   261 KTAFLMGLFVAASSLGGLFGGKMGDFLSTRLPNSGRIilaqissasaipLAAILLLVLPDDPSTAAIHGLILVLLGLFV 339
Cdd:TIGR00895 286 LAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLL------------LGAVFAVLVGSTLFSPTLLLLLGAIAGFFV 352
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 73-394 6.77e-10

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 60.71  E-value: 6.77e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  73 VIALGAFLWSAATFLVAFSSTFFQVAVSRALNGIGLALVAPAIQSLVADSTDDANRGTAFGWLQLTANIGSILGGLcsvl 152
Cdd:cd17475  63 VLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAA---- 138

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 153 IAPLTFMGIpGWRVAFHIVGVISVIVGVLVRVFANDPhfvkdgVDVSNQPGSRKPFCTEVKDLVREadtvikiRSFQIIV 232
Cdd:cd17475 139 LLPPLALHY-GWRAAFVVAGLVSILAAVLFWLFYREP------PAASAATESASTLLRSLKEVLRN-------RDVWLIA 204

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 233 AQGVTGSFP-WSALSFAPMWL-ELIGFSHGKTAFLMglfvAASSLGGLFGGKMGDFLSTRLPNSGRIILaqISSASAIPL 310
Cdd:cd17475 205 IAGALLVAPqFALLTFLLLFLhDHLGLSVVAAGALL----AVAQLGGALGRIGLGRVSDRVFGGRRRPV--LVITAAIAA 278

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 311 AAILLLVLPDDPSTAAIHGLILVLLGLFVS-WNAPATNnpIFAEIVPEKSRTSVYALDKSFESILSSFAPPIVGILAQHV 389
Cdd:cd17475 279 AALLVLSLLSPGTPLWLLVLLLILLGLFAIgWNGLYLT--LVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDAT 356


                ....*
gi 28416565 390 YGYKP 394
Cdd:cd17475 357 HSYAP 361
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 73-394 1.06e-09

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 59.89  E-value: 1.06e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  73 VIALGAFLWSAATFLVAFSSTFFQVAVSRALNGIGLALVAPAIQSLVADSTDDANRGTAFGWLQLTANIGSILGGLCSVL 152
Cdd:cd17319  70 VLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGW 149

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 153 IapltfMGIPGWRVAFHIVGVISVIVGVLVRVFandphfvkdgvdvsnqpgsrkpfctevkdlvreadtvikIRSFQIIV 232
Cdd:cd17319 150 L-----LLLFGWRWAFIIEGLLGLLLAVLWWFY---------------------------------------LRQVWGLA 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 233 AQGVTGSFPWSALSFapmWLELIGFS-HGKTAFLMGLFVAASSLGGLFGGKMGDFLSTRLPNSGRIILAQISSASAiplA 311
Cdd:cd17319 186 LGYFGINYALYGLLT---WLPTYLKQaRGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLA---A 259

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 312 AILLLVLPDDPSTAAIHGLILVLLGLFvSWNAPATNNPifAEIVPEKSRTSVYALDKSFESILSSFAPPIVGILAQHVYG 391
Cdd:cd17319 260 VGLLLAYLTTSPVVAVILLSLAGFGIG-AASPVFWSLP--ADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGS 336


                ...
gi 28416565 392 YKP 394
Cdd:cd17319 337 YTA 339
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 8-345 1.59e-09

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 59.49  E-value: 1.59e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565   8 LLLVNLAGIMERADESLLPGVYKEVGLALHTDPTGLGSLTLLRSMVQAACYPLAAYMAIRHNRAHVIALGAFLWSAATFL 87
Cdd:cd17324   1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  88 VAFSSTFFQVAVSRALNGIGLALVAPAIQSLVADSTDDANRGTAFGWLQLTANIGSILGGLCSVLIAPLTfmgipGWRVA 167
Cdd:cd17324  81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLL-----GWRAA 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 168 FHIVGVISVIVGVLVRVFANDphfvkdgvDVSNQPGSRKPFCTEVKDLVReadtvIKIRSFQIIVAQGVTGSF-PWSALs 246
Cdd:cd17324 156 FLAIAVLALLAALLLWRLLPS--------LPPKKPGSLGLLSSLLLLLRN-----PRLRLAYLITFLLFGGFFaLYTYL- 221

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 247 fAPMWLELIGFSHGKTAFLMGLFVAASSLGGLFGGKMGDFLSTRlpnsgriilaQISSASAIPLAAILLLVLPDDPSTAA 326
Cdd:cd17324 222 -APFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRR----------ALLIALLLLAAALLLLTLLGPSPLLL 290

                       330
                ....*....|....*....
gi 28416565 327 IhgLILVLLGLFVSWNAPA 345
Cdd:cd17324 291 L--VGLVLWGLGFFAAHSA 307
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 23-346 2.56e-09

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 58.72  E-value: 2.56e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  23 SLLPGVYKEVGLALHTDPTGLGSLTLLRSMVQAACYPLAAYMAIRHNRAHVIALGAFLWSAATFLVAFSSTFFQVAVSRA 102
Cdd:cd17478  13 GFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVA 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 103 LNGIGLALVAPAIQSLVAdSTDDANRGTAFGWLQLTANIGSILGGLCSVLIapLTFMGIPGWRVAFhivGVISVIVGVLV 182
Cdd:cd17478  93 LAGIGSAAFHPEGARLAS-QAAGGRRGLAMSIFSVGGNLGFALGPLIAAAL--VALFGGLGLLILL---IIPGLAVALLL 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 183 RVFANDPHFVKDGVDVSNQPGSRKpfctevkdlvreadtVIKIRSFQIIVAQGVTGSFPWSALS-FAPMWLELIGFSHGK 261
Cdd:cd17478 167 LRLRPLKKPEAKKAAAKSSARSTL---------------KGVWRALLLLLIIVFLRSWVLSSLTtFLPFYLVQRGYSLVF 231

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 262 TAFLMGLFVAASSLGGLFGGKMGDFLSTRlpnsgRIILaqISSASAIPLAAILLLVlpddPSTAAIhgLILVLLGLFVSW 341
Cdd:cd17478 232 AGLLLSLFLFAGAIGTLIGGPLSDRFGRR-----RVII--ASLLLAAPFLLLFLLT----PGIWSY--ILLVLAGFLLFA 298


                ....*
gi 28416565 342 NAPAT 346
Cdd:cd17478 299 SFPVT 303
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 36-437 3.23e-09

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 58.72  E-value: 3.23e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  36 LHTDPTGLGSLTLLRSMVQAACYPLAAYMAIRHNRAHVIALGAFLWSAATFLVAFSSTFFQVAVSRALNGIGLALVAPAI 115
Cdd:cd17321  26 LGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPAS 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 116 QSLVADSTDDANRGTAFGWLQLTANIGSILGGLCSVLIAPLtfmgiPGWRVAFhivgvisvivgvLVRVfandphfvkdg 195
Cdd:cd17321 106 LALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLEL-----FGWRWIF------------LINV----------- 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 196 vdvsnqpgsrkPFCtevkdlvreADTVIKIRSFQIIVAQGVTGSFPWSALSF-APMWLELI-GFSHGKTAFLMGLFVAAS 273
Cdd:cd17321 158 -----------PIG---------LVALLLARTFSGAVLAAFLLGAALGGLLFlLPLYLQGVlGYSPLQAGLALLPLALAM 217

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 274 SLGGLFGGKMGDFLSTRLPNSGRIILAQISSasaiplaAILLLVLPDDPSTAAIHGLILVLLGLFVSWnAPATNNPIFAe 353
Cdd:cd17321 218 LVAAPLAGRLADRFGPRLVLVAGLLLTAVGL-------LLLALLGADSSVWLLLPGLVLLGLGLGLFA-TPLTNAALSS- 288

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 354 iVPEKSRTSVYALDKSFESILSSFAPPIVGILAQHVYGYKPIPEGSSRSTEIATDrENAASLAKALYTSIGLpMAACCFI 433
Cdd:cd17321 289 -VPKEKAGAASGILNTARQLGGALGVALLGALLTAGLSANLGDSGVAALLSAAAA-AFAAGFHLAFLVAAAL-ALLAALL 365


                ....
gi 28416565 434 YSFL 437
Cdd:cd17321 366 ALLL 369
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
36-145 7.23e-09

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 57.29  E-value: 7.23e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  36 LHTDPTGLGSLTLLRSMVQAACYPLAAYMAIRHNRAHVIALGAFLWSAATFLVAFSSTFFQVAVSRALNGIGLALVAPAI 115
Cdd:COG2814 238 LGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLL 317

                        90       100       110
                ....*....|....*....|....*....|
gi 28416565 116 QSLVADSTDDANRGTAFGWLQLTANIGSIL 145
Cdd:COG2814 318 QALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 59-395 8.53e-09

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 57.22  E-value: 8.53e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  59 PLAAYMAIRHNRAHVIALGAFLWSAATFLVAFSSTFFQVAVSRALNGIGLALVAPAIQSLVADSTDDANRGTAFGWLQLT 138
Cdd:cd17489  49 PFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLA 128

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 139 ANIGSILGGLCSVLIAPLTfmgipGWRVAFHIVGVISVIVGVLVRvfandphFVKDgvdvsnqPGSRKPFCTEVKDLVRE 218
Cdd:cd17489 129 TTLAMALGPALGLFLYQHL-----GFAVLFIVAAVLALLALLLVF-------LVKD-------PPPVAAEEAEAGTRAFR 189

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 219 ADTVIKIRSFQIIVAqgvTGSFPWSA-LSFAPMWLELIGFSHgkTAFLMGLFVAASSLGGLFGGKMGDFLstrlpnsGRI 297
Cdd:cd17489 190 RLVEKKVLPPALILF---LASIAYGAiSTFLPLYAAERGISN--AGLFFTVYAIALLLSRPFSGKLSDRK-------GPK 257

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 298 ILAQISSASAIplAAILLLVLPDDPSTAAIHGlilVLLGLFVSWNAPATNNPIFAEIVPEKsRTSVYALDKSFESILSSF 377
Cdd:cd17489 258 TVIIPGLLLLA--LGLLLLSFAGSPWMLLLAA---VLYGLGFGLLFPALQALAVDLVPPHR-RGAANGTFFIFFDLGIGL 331

                       330
                ....*....|....*...
gi 28416565 378 APPIVGILAQHvYGYKPI 395
Cdd:cd17489 332 GGLLLGLVAEL-FGYRAM 348
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
39-449 1.90e-08

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 56.45  E-value: 1.90e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  39 DPTGLGSLTLLRSMVQAACYPLAAYMAIRHN-----RAHVIALGAFLWSAATFLVAFSSTFFQ------VAVSRALNGIG 107
Cdd:COG2211  44 SAALVGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAIPLALSFVLLFTAPDLSPtgkliyALVTYLLLGLA 123

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 108 LALVAPAIQSLVADSTDDAN-RGTAFGWLQLTANIGSILGGLCSVLIAPLTFMGIP-GWRVAFhIVGVISVIVGVLVRVF 185
Cdd:COG2211 124 YTLVNIPYSALGAELTPDYEeRTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAAlGYRLTA-LIFAVLGLLAFLLTFF 202

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 186 andphFVKDGVDVSNQPGSrkpfcteVKDLVReadTVIKIRSFQIIVAQGVTGSFPWSALS--FAPMWLELIGFSHGKTA 263
Cdd:COG2211 203 -----GTKERPVPEEEKVS-------LKESLK---ALLKNRPFLLLLLAYLLFFLALALVAalLLYYFKYVLGLSAALVG 267

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 264 FLMGLFVAASSLGGLFGGKMGDFLstrlpnsGRIILAQISSASAIPLAAILLLVLPDDPSTAAIhglILVLLGLFVSwNA 343
Cdd:COG2211 268 LLLALYFLAALLGAPLWPRLAKRF-------GKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLV---LAALAGIGLG-AI 336

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 344 PATNNPIFAEIVPE------KSRTSVY-ALDKSFESILSSFAPPIVGILAQHVyGYKPipegssrsteiatDRENAASLA 416
Cdd:COG2211 337 LVLPWAMLADVVDYdewktgRRREGLYfGIFTFAIKLGQALAGALAGLLLALF-GYVA-------------GAAQSPSAL 402

                       410       420       430
                ....*....|....*....|....*....|...
gi 28416565 417 KALYTSIGLPMAACCFIYSFLYRSYPLDRDRAR 449
Cdd:COG2211 403 TGIRLLFFLLPAVLLLLAALLLLFYPLTRERHA 435
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
6-392 2.41e-08

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 56.03  E-value: 2.41e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565   6 MTLLLVNLAGIMERADESLLPGVYKEVGLALHTDPTGLGSLTLLRSMVQAACYPLAAYMAIRHNRAHVIALGAFLWSAAT 85
Cdd:COG2807  18 LLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGL 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  86 FLVAFSSTFFQVAVSRALNGIGLALVAPAIQSLVADSTDDaNRGTAFGWLQLTANIGSILGGLCSVLIAPLTfmgipGWR 165
Cdd:COG2807  98 LLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPD-RVGLMTGLYTAAMGLGAALAAGLTVPLAAAL-----GWR 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 166 VAFHIVGVISVIVGVLVRVFANDPHfvkdgvdvsnQPGSRKPFCTEVKDLVREAdtvikiRSFQIIVAQGVTGSFPWSAL 245
Cdd:COG2807 172 GALAVWALLALLALLLWLPLLRRRP----------AAAAAAPAAASLRSLWRSP------LAWLLTLFFGLQSLLYYAVV 235

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 246 SFAPMWLELIGFSHGKTAFLMGLFVAASSLGGLFGGkmgdFLSTRLPNSGRIILAqissASAIPLAAILLLVLPddPSTA 325
Cdd:COG2807 236 AWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVP----LLADRLGDRRPLLLL----LGLLGLAGLLGLLLA--PGSL 305

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 28416565 326 AIhgLILVLLGLfvswnAPATNNPIFAEIVPEKSRT-----SVYALDKSFESILSSFAPPIVGILAQHVYGY 392
Cdd:COG2807 306 PW--LWAVLLGL-----GQGGLFPLALTLIGLRARTpaeaaALSGMAQSVGYLLAALGPLLVGALHDATGSW 370
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 35-388 3.37e-08

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 55.27  E-value: 3.37e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  35 ALHTDPTGLGSLTLLRSMVQAACYPLAAYMAIRHNRAHVIALGAFLWSAATFLVAFSSTFFQVAVSRALNGIGLALVAPA 114
Cdd:cd17474  28 ALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPL 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 115 IQSLVADSTDDANRGTAFGWLQLTANIGSILGGLCSVLIAPLtfmgipGWRVAFHIVGVISVIVGVLVRVFANDPHfvkD 194
Cdd:cd17474 108 ALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI------SWRYPFFLLAALIPVAFLAILFLLPEPK---E 178

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 195 GVDVSNQPGSRKPFctevkdlvrEADTVIKIRSFQIIVAQGVTGSFPWsaLSFAPMwleLIGFSHGKTAFLMGLFVAASS 274
Cdd:cd17474 179 KAKSSSATKLRDLK---------KALRGRGLLTFLVSAFLYFFLYFAF--LTYLPF---LLELLYGISPIIIGLLFAGWS 244

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 275 LGGLFGGkmgdflstrlPNSGRIILAQISSASAIPLA----AILLLVLPddpstaAIHGLILVLLGLFVSWNAPATNNPI 350
Cdd:cd17474 245 VLLALGS----------LFVGRLLKKRFGARRILVIGlllyALSLLLLG------FVPSLALLLIAIVLFGLGLGLNLPL 308

                       330       340       350       360
                ....*....|....*....|....*....|....*....|..
gi 28416565 351 F----AEIVPEKSRTSVYALDKSFESILSSFAPPIVGILAQH 388
Cdd:cd17474 309 LttlvTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEI 350
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 44-148 2.20e-07

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 53.00  E-value: 2.20e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  44 GSLTLLRSMVQAACYPLAAYMAIRHNRAHVIALGAFLWSAATFLVAFSSTFFQVAVSRALNGIGLALVAPAIQSLVADST 123
Cdd:cd17329  38 GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVT 117

                        90       100
                ....*....|....*....|....*
gi 28416565 124 DDANRGTAFGWLQLTANIGSILGGL 148
Cdd:cd17329 118 TPENRTRAFSLLYWAINLGVAIGPL 142
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 60-168 5.06e-07

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 51.79  E-value: 5.06e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  60 LAAYMAIRHNRAHVIALGAFLWSAATFLV--AFSSTFFQVAVSRALNGIGLALVAPAIQSLVADSTDDANRGTAFGWLQL 137
Cdd:cd17380  53 LGGYLADRFGGKKVLLLAVALWSLATLLTplLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTA 132

                        90       100       110
                ....*....|....*....|....*....|..
gi 28416565 138 TANIGSILGGL-CSVLIAPLtfmgipGWRVAF 168
Cdd:cd17380 133 GSYLGTLLGGLiGPLLLEYY------GWPSVF 158
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 41-394 6.19e-07

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 51.61  E-value: 6.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565    41 TGLGSLTLLRSMVQAACYPLAAYMAIRHNRAHVIALGAFLWSAATFLVAFSSTFFQVAVSRALNGIGLALVAPAIQSLVA 120
Cdd:TIGR00881  30 TDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVT 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565   121 DSTDDANRGTAFGWLQLTANIGsiLGGLCSVLIAPLTFMGipGWRVAFHIVGVISVIVGVLV-RVFANDPHFVKDG-VDV 198
Cdd:TIGR00881 110 KWFSRSERGTWVSFWNCSHNVG--GGLLPPLVLFGIAELY--SWHWVFIVPGIIAIIVSLICfLLLRDSPQSCGLPpAEE 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565   199 SNQPGSRKPFCTEVKDLVREADTVIKI-RSFQIIV---AQGVTGSFPWSALSFAPMWL-ELIGFSHGKTAFLMGLFvaas 273
Cdd:TIGR00881 186 MPNEEPDGDAEKKEEELTKKQIFLQYVlLNKVLWYislGYVFVYVVRTGILDWSPLYLtQEKGFSKEKASWAFTLY---- 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565   274 SLGGLFGGKMGDFLSTRLPNSGRIILAQISSASAIPLAAILLLVLPDDPSTAAIhglILVLLGLFVswnapatNNPIF-- 351
Cdd:TIGR00881 262 ELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLI---CLFALGFLV-------YGPQMli 331

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 28416565   352 ----AEIVPEKSRTSVYALDKSFESILSSFAPPIVGILAQHvYGYKP 394
Cdd:TIGR00881 332 gviaSELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADG-FGWAG 377
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
35-389 7.41e-07

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 51.39  E-value: 7.41e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  35 ALHTDPTGLGSLTLLRSMVQAACYPLAAYMAIRHNRAHVIALGAFLWSAATFLVAFSSTFFQVAVSRALNGIGLALVAPA 114
Cdd:COG0738  37 AFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVA 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 115 IQSLVADSTDDaNRGTAFGWLQLTANIGSILGGLcsvLIAPLTFMGI-PGWRVAFhIVGVISVIVGVLVRVFANDPHFVK 193
Cdd:COG0738 117 ANPYVAALGPE-TAASRLNLLHAFFSLGALLGPL---LGGLLILLGLsLSWHLPY-LILAVLLLLLALLFLRSKLPEIEE 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 194 DGVDVSNQPGSRKpfctevkdlvreadTVIKIRSF-QIIVAQGVTGSFPWSALSFAPMWLELI-GFSHGKTAFLMGLFVA 271
Cdd:COG0738 192 EEEEAAGSAASLK--------------SLLKNPRLlLGGLAIFLYVGAEGAIGDWLPLYLKDVlGLSEATAALGLSLFWG 257

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 272 ASSLGGLFGGkmgdFLSTRLpnsGRIILAQISSASAIplAAILLLVLPDDPSTAAIhglILVLLGLFVSWNAPATnNPIF 351
Cdd:COG0738 258 GMTIGRFLGG----FLLKRF---GPVRLLRLSALLAA--VGLLLALLAPGPWLALI---GLALVGLGLSLMFPTI-FSLA 324

                       330       340       350       360
                ....*....|....*....|....*....|....*....|..
gi 28416565 352 AEIVPEKSRTSVyaldkSFESILSSFA----PPIVGILAQHV 389
Cdd:COG0738 325 LDGLGKRTAAAV-----SAVLIMGIVGgaigPPLIGFLADAF 361
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 59-388 1.60e-06

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 50.30  E-value: 1.60e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  59 PLAAYMAIRHNRAHVIALGAFLWSAATFLVAFSSTFFQVAVSRALNGIGLAL-VAPAIQSLVADSTDDANRgtAFGWLQL 137
Cdd:cd17490  50 PLGILSDRIGKRKLFIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAATwVSFTVLYASYFPPDEAAK--AMGLINL 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 138 TANIGSILGGLCSVLIAPLTfmgipGWRVAFhivgvisvivgvLVRVFANDPHFVKdGVDVSNQPGSRKPFCTEVKDLVR 217
Cdd:cd17490 128 VNNLGQLIAFLIGGLIAEHF-----GMRAPF------------LLAALAGVLGFIL-SLFIKEERREKKPVLTELKELLS 189

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 218 EA-DTVIKIRSFQIIVAQGVTGSFPWsalSFAPMWLELIGFSHGKTAFLMGLFVAASSLGGLFGgkmGDFLSTRLPNSGR 296
Cdd:cd17490 190 VLkDKKLLFFSLLAILQQMITFSTTF---GFTPLIAKQLGASSFQLGLLSIIYLLPNALASLLS---GTLFYKKLGERNT 263

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 297 IILaqissaSAIPLAAILLLVlpddPSTAAIHGLILV--LLGLFVSWNAPATNNPIFaEIVPEKSRTSVYALDKSFESIL 374
Cdd:cd17490 264 III------GFLLLGAYCFLI----PFAPNLTLLYLLqaLNGFGTGILFPLLMSLSI-EGVPAEQRSTAMGFFQAIYALG 332

                       330
                ....*....|....
gi 28416565 375 SSFAPPIVGILAQH 388
Cdd:cd17490 333 MFLGPVLVGIISEA 346
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 35-392 2.23e-06

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 49.58  E-value: 2.23e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  35 ALHTDPTGLGSLTLLRSMVQAACYPLAAYMAIRHNRAHVIALGAFLWSAATFLVAFSSTFFQVAVSRAL-NGIGLALVAP 113
Cdd:cd17355  32 EFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLlGGGGAGTLAA 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 114 AIQSLVADSTDDANRGTAFGwlqltanIGSILGGLCSVLIAPLTFMGIP--GWRVAFHIVGVISVIVGVLVRVFAnDPHF 191
Cdd:cd17355 112 VAFATVAAWWFERRRGLALG-------ILTAGGGLGSLVFLPLGAALIEafGWRTALLVLALLALLVLVPVLLLL-RRRP 183

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 192 VKDGVDVSNQPGSRKPFCTevkdlVREAdtvIKIRSFQIIVAQGVTGSFPWSALSFA-PMWLELIGFSHGKTAFLMGLFV 270
Cdd:cd17355 184 ADLALRAYDDASPASPGST-----LKEA---LRSASFWLLALAFFLCGFAVVGLIVHlVPYLADRGISPAAAAVALALIG 255

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 271 AASSLGGLFGGKMGDFLSTRLPnsgriilaqISSASAIPLAAILLLVLPDDPSTAAIhgLILVLLGLFVSWNAPATNNpI 350
Cdd:cd17355 256 LFNIVGRLLSGWLGDRYSPRRL---------LAASYALRALGLALLLLLPFPPLALL--LFAALFGLGWGATVPLTAA-L 323

                       330       340       350       360
                ....*....|....*....|....*....|....*....|..
gi 28416565 351 FAEIVPEKSRTSVYALDKSFESILSSFAPPIVGILAQHVYGY 392
Cdd:cd17355 324 AARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSY 365
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 51-148 3.48e-06

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 49.11  E-value: 3.48e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  51 SMVQAACYPLAAYMAIRHNRAHVIALGAFLWSAATFLVAFSSTFFQVAVSRALNGIGLALVaPAIQSLVADSTDDANRGT 130
Cdd:cd17330  44 SLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNV-SVAQAYIADITDEEERAK 122

                        90
                ....*....|....*...
gi 28416565 131 AFGWLQLTANIGSILGGL 148
Cdd:cd17330 123 AFGIISAAFGLGFILGPA 140
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 60-146 4.54e-06

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 48.73  E-value: 4.54e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  60 LAAYMAIRHNRAHVIALGAFLWSAATFLVAFSSTFFQVAVSRALNGIGLALVAPAIQSLVADSTDDANRGTAFGWLQLTA 139
Cdd:cd17330 230 LIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQ 309


                ....*..
gi 28416565 140 NIGSILG 146
Cdd:cd17330 310 SLARIIG 316
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 34-388 5.68e-06

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 48.38  E-value: 5.68e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  34 LALHTDPTGLGSLTLLRSMVQAACYPLAAYMAIRHNRAHVIaLGAFLWSAATFLVAF------SSTFFQVAVSRALNGIG 107
Cdd:cd06173  27 LQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLL-ILADLLRALLAAVLAllallgSLSLWLLLVLAFLLGIA 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 108 LALVAPAIQSLVADSTDDANRGTAFGWLQLTANIGSILG-GLCSVLIAPLtfmgipGWRVAFHIVGVISVIVGVLVRvfa 186
Cdd:cd06173 106 SAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGpALGGLLVALL------GPGGAFAINALSFLLSALLLL--- 176

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 187 ndphfvkdGVDVSNQPGSRKPFCTEVKDLVREADTVIKIRSFQIIVAQGVTGSFPWSAL-SFAPMWLELIGfshGKTAFL 265
Cdd:cd06173 177 --------FIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALtVLLPLLAKEVL---GGGAAG 245

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 266 MGLFVAASSLGGLFGGkmgdFLSTRLPNSGRIILAQISSASAIPLAAILLLVLPDDPSTAAihglILVLLGLFVSWNAPa 345
Cdd:cd06173 246 YGLLLAAFGVGALLGA----LLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLA----ALFLLGLAGGLFNV- 316

                       330       340       350       360
                ....*....|....*....|....*....|....*....|...
gi 28416565 346 TNNPIFAEIVPEKSRTSVYALDKSFESILSSFAPPIVGILAQH 388
Cdd:cd06173 317 PLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADA 359
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 59-392 8.59e-06

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 47.95  E-value: 8.59e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  59 PLAAYMAIRHNRAHVIALGAFLWSAATFLVAFSSTFFQVAVSRALNGIGLALVAPAIQSLVADSTDDANRGTAFGWLQLT 138
Cdd:cd17473  53 PLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAA 132

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 139 ANIGSILGGLCSVLIAPLtfmgipGWRVAFhivgvISVIVGVLVRVFAndPHFVKDGVDVSNQPGSRKPfctevkdlvRE 218
Cdd:cd17473 133 MSLGGVVFLLLGGALAEI------GWRAPF-----LVYLLALPVLILV--LLFLPEPARKSKSAASPGA---------AT 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 219 ADTVIKIRSFQIIVAQGVTGSFPWSALSFAPMwleLIGFSHGKTAFLMGLFVAASSLGGLFGGKMGDFLSTRLPNSGRII 298
Cdd:cd17473 191 AAALPWKRVLPIYFLAFLAMLLFYVIPIQLPF---LLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLA 267

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 299 LAQISSASA---IPLAAILLLVLpddpstaaihgLILVLLGLFVSWNAPATNNPIfAEIVPEKSRTSVYALDKSFESILS 375
Cdd:cd17473 268 IGFALMALGfllLALASGLWVVL-----------LGAILAGLGFGLLLPTLNSWA-MSLVPPELRGRAMGIVTSAFFLGQ 335

                       330
                ....*....|....*..
gi 28416565 376 SFAPPIVGILAQHVYGY 392
Cdd:cd17473 336 FLSPLVLGPLVNLTGGL 352
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
36-148 9.06e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 47.97  E-value: 9.06e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  36 LHTDPTGLGSLTLLRSMVQAACYPLAAYMAIRHNRAHVIALGAFLWSAATFLVAFS--STFFQVAVSRALNGIGLALVAP 113
Cdd:COG2211 259 LGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILV 338

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 28416565 114 AIQSLVADSTDDA-------NRGTAFGWLQLTANIGSILGGL 148
Cdd:COG2211 339 LPWAMLADVVDYDewktgrrREGLYFGIFTFAIKLGQALAGA 380
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 36-168 1.30e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 47.42  E-value: 1.30e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  36 LHTDPTGLGSLTLLRSMVQAACYPLAAYMAIRH-NRAHVIALGAFLWSAATFLVAFSSTFFQVAVSRALNGIGLALVAPA 114
Cdd:cd06174 234 GGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLiGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPL 313

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 28416565 115 IQSLVADSTDDANRGTAFGWLQLTANIGSILGGLCSVLIAPLTFmgipGWRVAF 168
Cdd:cd06174 314 SFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF----GLTGAF 363
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 43-168 1.76e-05

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 46.81  E-value: 1.76e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  43 LGSLTLLRSMVQAAcypLAAYMAIRHNRAHVIALGAFLWSAATFLVAFSSTFFQVAVSRALNGIGLALVAPAIQSLVADS 122
Cdd:cd17365  39 VGSAALFGMAIGAL---LAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEY 115

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 28416565 123 TDDANRGTAFGWLQLTANIGSILGGLCSVLIAPLTfmgipGWRVAF 168
Cdd:cd17365 116 APARRRSLAVTLMFCGYPLGAALGGFLAAALIPAF-----GWRSVF 156
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 73-389 1.99e-05

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 46.77  E-value: 1.99e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  73 VIALGAFLWSAATFLVAFSSTFFQVAVSRALNGIGLALVAPAIQSLVADSTDDANRGTAFGWLQLTANIGSILGGLCSVL 152
Cdd:cd17370  67 LVILGYGLSALAKPLLALAGSWQLVLLLRILERLGKGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAAL 146

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 153 IAPLTFMGIpgwRVAFHIVGVISVIVGVLVRVFANDPhfvkdgvdvsnqPGSRKPFCTEVKDLVREADTVIKIrsFQIIV 232
Cdd:cd17370 147 LLYLLGGNY---RTIFLLAAIPALLALLILLFVVKEY------------PRPPKLRKKSKKTSLKKLPKAFWL--YLLAV 209

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 233 AQGVTGSFPWsalSFAPMWLELIGFSHGKTAFLMGLFVAASSLGGLFGGKMGDflstrlpNSGRIILAQISSASAIplAA 312
Cdd:cd17370 210 ALFALGNFSF---AFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSD-------RIGRKKLLILGYLSLA--LA 277

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 28416565 313 ILLLVLPDDPSTAAIhglILVLLGLFVSwnAPATNNPIF-AEIVPEKSRTSVYALDKSFESILSSFAPPIVGILAQHV 389
Cdd:cd17370 278 YLGFALGSSLWLLLL---GFILWGLYMG--AQESIERAAvADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLI 350
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 24-146 2.09e-05

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 46.86  E-value: 2.09e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  24 LLPGVYKEVGLALHTDPTGLGSLTLLRSMVQAACYPLAAYMAIRHNRAHVIaLGAFLWSAATFLV-AFSSTFFQVAVSRA 102
Cdd:cd17388  21 VLPTLLREFVGDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVL-LLSLAGAALDYLLmAFAPTLWWLYLGRI 99

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 28416565 103 LNGIGLALVAPAiQSLVADSTDDANRGTAFGWLQLTANIGSILG 146
Cdd:cd17388 100 IAGITGATGAVA-AAYIADVTPPEQRARNFGLLGAAFGLGFIAG 142
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 60-157 2.47e-05

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 46.45  E-value: 2.47e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  60 LAAYMAIRHNRAHVIALGAFLWSAATFLVAFSSTFFQVAVSRALNGIGLALVAPAIQSLVADSTDDANRGTAFGWLQLTA 139
Cdd:cd06173 263 LLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALN 342

                        90
                ....*....|....*...
gi 28416565 140 NIGSILGGLCSVLIAPLT 157
Cdd:cd06173 343 SGAMPLGALLAGLLADAL 360
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 48-148 2.66e-05

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 46.38  E-value: 2.66e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  48 LLRSMVQAACYPLAAYMAIRHNRAHVIALGAFLWSAATFLVAFSSTFFQVAVSRALNGIGLALVAPAIQSLVADSTDDAN 127
Cdd:cd17370 241 ALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAEL 320

                        90       100
                ....*....|....*....|.
gi 28416565 128 RGTAFGWLQLTANIGSILGGL 148
Cdd:cd17370 321 RGTAYGLFNTVVGIGWLLASL 341
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
35-168 2.79e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 46.40  E-value: 2.79e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  35 ALHTDPTGLGSLTLLRSMVQAACYPLAAYMA--IRHNRAHVIALGAFLWSAATFLVAFSSTFFQVAVSRALNGIGLALVA 112
Cdd:COG2271 210 VRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSdrLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAF 289

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 28416565 113 PAIQSLVADSTDDANRGTAFGWLQLTANIGSILGGLCSVLIAPLTfmgipGWRVAF 168
Cdd:COG2271 290 GLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT-----GYQAAF 340
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 86-393 3.59e-05

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 46.10  E-value: 3.59e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  86 FLVAFSSTFFQVAVSRALNGIgLALVAPAIQSLVADSTDDANRGTAFGWLQLTANIGSILGGLCSVLIAPLTfmgipGWR 165
Cdd:cd17391  81 GLMAFVTNVWQLLILRLLQGV-FSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLF-----GIR 154

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 166 VAFhivgviSVIVGVLVRVFANDPHFVKDGvdvsnqpgsRKPFCTEVKDLVREADTVIKirSFQIIVAQGVTGSFPWSAL 245
Cdd:cd17391 155 NVF------FITGGLLFLAFLLTLFFVKED---------FKPVEKKKMVSTKEVWNSVP--NPSLLISLFVTTFIIQLAN 217

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 246 -SFAP---MWLELIGFSHGKTAFLMGLFVAASSLGGLFG----GKMGDflstRLPNSGRIILAQissasaipLAAILLLV 317
Cdd:cd17391 218 qSIEPiltLYIRQLMGDASNLAFISGLVFSATGVSSLLSaprlGKLGD----RIGHHRILLGAL--------LASALLYI 285

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28416565 318 LPDDPSTAAIHGLILVLLGLFVSWNAPATnNPIFAEIVPEKSRTSVYALDKSFESILSSFAPPIVGILAQHvYGYK 393
Cdd:cd17391 286 PQAFVQTPWQLGILRFLLGLATGGLLPAI-NSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAH-FGYR 359
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 11-146 2.04e-04

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 43.72  E-value: 2.04e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  11 VNLAGIMERADESLLPGVYKEVGLALHTDPTGLGSLTLLRSMVQAACYPLAAYMAIRHNRAHVIALGAFLWSAATFLVAF 90
Cdd:cd17503   1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 28416565  91 SSTFFQVAVSRALNGIGLALVAPAIQSLVADSTDDANRGTAFGWLQLTANIGSILG 146
Cdd:cd17503  81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIG 136
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 55-339 2.40e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 43.32  E-value: 2.40e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  55 AACYPLAAYMAIRHNRAHVIALGAFLWSAATFLVAFSSTFFQVAVSRALNGIGLALVAPAIQSLVADSTDDANRGTAFGW 134
Cdd:cd17477  45 LLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGL 124

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 135 LQLTANIGSILGGLCsvliapLTFMGIPGWRVAFHIVGVISVIVGVLVRVFANDPhfvkdgvdVSNQPGSRKPFctevkd 214
Cdd:cd17477 125 YSTVLGLGFALGPLL------LALVGTAGALPFLIAAVLLLLALVPLLLTRRAAP--------EIEEAESISLR------ 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 215 lvreadTVIKIrSFQIIVAQGVTGSFPWSALSFAPMWLELIGFSHGKTAFLMGLFVAASSLGGLFGGKMGDFLstrlpns 294
Cdd:cd17477 185 ------RLLRI-APLALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRF------- 250

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 28416565 295 GRIILAQISSASAIpLAAILLLVLPDDPSTAAIhglILVLLGLFV 339
Cdd:cd17477 251 DRRRVLLGCALLGA-LAALLLPLVPGLPLALLV---LLFLWGGAA 291
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 43-146 3.66e-04

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 42.59  E-value: 3.66e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  43 LGSLTLLRSMVQAACYPLAAYMAIRHNRAH-VIALGAFLWSAATFLVAFSSTFFQVAVSRALNGIGLALVAPAIQSLVAD 121
Cdd:cd17490 232 LGLLSIIYLLPNALASLLSGTLFYKKLGERnTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIE 311

                        90       100
                ....*....|....*....|....*
gi 28416565 122 STDDANRGTAFGWLQLTANIGSILG 146
Cdd:cd17490 312 GVPAEQRSTAMGFFQAIYALGMFLG 336
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 72-154 3.80e-04

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 42.64  E-value: 3.80e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  72 HVIALGAFLWSAATFLV-AFSSTFFQVAVSRALNGIGLALVAPAIQSLVADSTDDANRGTAFGWLQLTANIGSILGGLCS 150
Cdd:cd17391 270 HRILLGALLASALLYIPqAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLG 349


                ....
gi 28416565 151 VLIA 154
Cdd:cd17391 350 SAIA 353
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 76-168 6.17e-04

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 41.86  E-value: 6.17e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  76 LGAFLWSAATFLVAFSSTFFQVAVSRALNGIGLALVAPAIQSLVADSTDDAN-RGTAFGWLQLTANIGSILGGLCSVLIA 154
Cdd:cd17476  68 IGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPrKNIVFSLFGATAPLGFALGGVFGGLFA 147

                        90
                ....*....|....
gi 28416565 155 PLTfmgipGWRVAF 168
Cdd:cd17476 148 QLA-----WWPWIF 156
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 67-339 8.29e-04

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 41.49  E-value: 8.29e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  67 RHNRAHVIALGAFLWSAATFLVAFSSTFFQVAVSRALNGIGLALVAPAIQSLVADSTDDANRGTAFGWLQLTANIGSILG 146
Cdd:cd17312  64 RSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILA 143

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 147 G-LCSVLIAPLtfmgipGWRVAFhivgVISVIVGVLVRVFandphfvkdgvdvsnqpgsrkpfcteVKDLVREADTVIKI 225
Cdd:cd17312 144 PiLAASLASYY------GWRAAF----LVPGIVGLVVAII--------------------------LFFFLRDSPPYVWV 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 226 RSFQIIVAQGVTGSFpwsaLSFAPMWL-ELIGFSHGKTAFLMGLFvaasSLGGLFGGKMGDFLSTRLPNSGRIILAQISS 304
Cdd:cd17312 188 LSLAYAFVYIVRYAC----LDWGPLYLyEVKGYSLIDAGWFSSLY----EVGGIAGTILAGLLSDKLFGGRRAPIAVIYM 259

                       250       260       270
                ....*....|....*....|....*....|....*
gi 28416565 305 ASAIpLAAILLLVLPDDPSTAAIhglILVLLGLFV 339
Cdd:cd17312 260 LLMT-LSLALFWFFPHNKLLSIV---LLFLIGFFV 290
MFS_YjiJ cd06180
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ...
 60-148 2.98e-03

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340869 [Multi-domain]  Cd Length: 371  Bit Score: 39.98  E-value: 2.98e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  60 LAAYMAIRHNRA-HVIALGAFLWSAATFLVAFSSTFFQVAVSRALNGIGLALVAPAIQSLVADSTDDANRGTAFGWLQLT 138
Cdd:cd06180  52 LLASFLRRRGRArRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAG 131

                        90
                ....*....|
gi 28416565 139 ANIGSILGGL 148
Cdd:cd06180 132 VGLGIALSGL 141
MFS_1 pfam07690
Major Facilitator Superfamily;
244-389 3.29e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 39.71  E-value: 3.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565   244 ALSFAPMWLELIGFSHGKTAFLMGLFVAASSLGGLFGGKMGDFLSTRlpnsgRIILAqissaSAIPLAAILLLVLPDDPS 323
Cdd:pfam07690  16 GPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRR-----RVLLI-----GLLLFALGLLLLLFASSL 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28416565   324 TAAIhgLILVLLGLFVSWNAPATNNpIFAEIVPEKSRTSVYALDKSFESILSSFAPPIVGILAQHV 389
Cdd:pfam07690  86 WLLL--VLRVLQGLGAGALFPAALA-LIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF 148
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 67-133 3.43e-03

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 39.51  E-value: 3.43e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 28416565  67 RHNRAHVIALGAFLWSAATFLVAFSSTFFQVAVSRALNGIGlALVAPAIqSLVADSTDDANRGTAFG 133
Cdd:cd17472  58 RIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSG-AISSVVM-ALLADLTREENRTKAMA 122
Sugar_tr pfam00083
Sugar (and other) transporter;
60-169 5.41e-03

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 39.18  E-value: 5.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565    60 LAAYMAIRHNRAHVIALGAFLWSAATFLVAFS---STFFQVAVSRALNGIGLALVAPAIQSLVADSTDDANRGTAFGWLQ 136
Cdd:pfam00083  65 FAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAkgkWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQ 144

                          90       100       110
                  ....*....|....*....|....*....|...
gi 28416565   137 LTANIGSILGGLCSVLIAplTFMGIPGWRVAFH 169
Cdd:pfam00083 145 LAITFGILLAYIFGLGLN--KTSNSDGWRIPLG 175
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 73-392 6.66e-03

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 38.69  E-value: 6.66e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565  73 VIALGAFLWSAATFLVAFSSTFFQVAVSRA-LNGIGLALVAPAIQSLVAdSTDDANRGTAFGwlqltanIGSILGGLCSV 151
Cdd:cd17352  70 VAIAGGLLAALGLLLSSFATSLWQLYLTYGvLGGLGLGLIYSPAIVIVG-QYFEKKRGLATG-------IAVAGSGVGTF 141

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 152 LIAPLT--FMGIPGWRVAFhivgvisvivgvlvRVFAndphfvkdGVDVSnqpgsrkpfCTEVKDLVReadtVIKIRSFQ 229
Cdd:cd17352 142 VFPPLLryLLDNYGWRGAL--------------LILG--------GLCLN---------LCVCGLLLR----LLKDPTFV 186

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 230 IIVAQGVTGSFPW-SALSFAPMWLELIGFSHGKTAFLMGLFVAASSLGGLFGGKMGDFLSTRLPNsgRIILAQISSAsai 308
Cdd:cd17352 187 LLALGVSFAMLGFfVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLY--LYIFTLLILG--- 261

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28416565 309 plAAILLLVLPDDPSTAAIhglILVLLGLFVSWNApATNNPIFAEIVPEKSRTSVYALDKSFESILSSFAPPIVGILAQH 388
Cdd:cd17352 262 --LSLLAFPLATTYVGLIV---FSVLFGFCSGSYS-SLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDY 335


                ....
gi 28416565 389 VYGY 392
Cdd:cd17352 336 TGDY 339
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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