NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|27762266|gb|AAO20271|]
View 

annexin 2b [Danio rerio]

Protein Classification

annexin( domain architecture ID 10446041)

annexin belongs to a family of calcium- and phospholipid-binding proteins that have been implicated in many cellular processes, including channel formation, membrane fusion, vesicle transport, and regulation of phospholipase A2 activity

CATH:  1.10.220.10
Gene Ontology:  GO:0005509|GO:0005544|GO:0048306|GO:0003723
PubMed:  15059252|1646719
SCOP:  4001063
TCDB:  1.A.31

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 108-172 7.40e-23

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 89.84  E-value: 7.40e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27762266   108 YDAFEL-KAMKGLGTDEESLIEMVCSRNKEELAEIKKVYKEMFKKDLEKDISGDTSGDFAKLLLAL 172
Cdd:pfam00191   1 YDAELLrKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 267-332 8.76e-17

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 73.66  E-value: 8.76e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27762266   267 YFASRLNDAMKGKSVKDKIITRIIVSRCEVDLMKVRIEFKRNFGRSLHQTISEHTKGDYQRALLNL 332
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 37-101 2.62e-14

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 66.73  E-value: 2.62e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27762266    37 DAAKIETAIKTKGVDEQTIIDILTRRSLLKRSDIAFEYEKRAKKDLVSALKGALSGSLEHLILGL 101
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 192-257 6.47e-13

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 62.88  E-value: 6.47e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27762266   192 DARTLYEtGVRRKGTDVVTWISIFSERSVSHLQKVFERYKRYSPYDLKESIRMEVKGDLEKSFLTL 257
Cdd:pfam00191   2 DAELLRK-AMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 108-172 7.40e-23

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 89.84  E-value: 7.40e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27762266   108 YDAFEL-KAMKGLGTDEESLIEMVCSRNKEELAEIKKVYKEMFKKDLEKDISGDTSGDFAKLLLAL 172
Cdd:pfam00191   1 YDAELLrKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
120-172 6.47e-19

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 78.99  E-value: 6.47e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 27762266    120 GTDEESLIEMVCSRNKEELAEIKKVYKEMFKKDLEKDISGDTSGDFAKLLLAL 172
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 267-332 8.76e-17

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 73.66  E-value: 8.76e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27762266   267 YFASRLNDAMKGKSVKDKIITRIIVSRCEVDLMKVRIEFKRNFGRSLHQTISEHTKGDYQRALLNL 332
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 37-101 2.62e-14

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 66.73  E-value: 2.62e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27762266    37 DAAKIETAIKTKGVDEQTIIDILTRRSLLKRSDIAFEYEKRAKKDLVSALKGALSGSLEHLILGL 101
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 192-257 6.47e-13

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 62.88  E-value: 6.47e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27762266   192 DARTLYEtGVRRKGTDVVTWISIFSERSVSHLQKVFERYKRYSPYDLKESIRMEVKGDLEKSFLTL 257
Cdd:pfam00191   2 DAELLRK-AMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
283-332 3.42e-12

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 60.50  E-value: 3.42e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 27762266    283 DKIITRIIVSRCEVDLMKVRIEFKRNFGRSLHQTISEHTKGDYQRALLNL 332
Cdd:smart00335   4 EKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
49-101 4.32e-11

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 57.42  E-value: 4.32e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 27762266     49 GVDEQTIIDILTRRSLLKRSDIAFEYEKRAKKDLVSALKGALSGSLEHLILGL 101
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
205-257 1.83e-09

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 52.79  E-value: 1.83e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 27762266    205 GTDVVTWISIFSERSVSHLQKVFERYKRYSPYDLKESIRMEVKGDLEKSFLTL 257
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 108-172 7.40e-23

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 89.84  E-value: 7.40e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27762266   108 YDAFEL-KAMKGLGTDEESLIEMVCSRNKEELAEIKKVYKEMFKKDLEKDISGDTSGDFAKLLLAL 172
Cdd:pfam00191   1 YDAELLrKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
120-172 6.47e-19

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 78.99  E-value: 6.47e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 27762266    120 GTDEESLIEMVCSRNKEELAEIKKVYKEMFKKDLEKDISGDTSGDFAKLLLAL 172
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 267-332 8.76e-17

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 73.66  E-value: 8.76e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27762266   267 YFASRLNDAMKGKSVKDKIITRIIVSRCEVDLMKVRIEFKRNFGRSLHQTISEHTKGDYQRALLNL 332
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 37-101 2.62e-14

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 66.73  E-value: 2.62e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27762266    37 DAAKIETAIKTKGVDEQTIIDILTRRSLLKRSDIAFEYEKRAKKDLVSALKGALSGSLEHLILGL 101
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 192-257 6.47e-13

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 62.88  E-value: 6.47e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27762266   192 DARTLYEtGVRRKGTDVVTWISIFSERSVSHLQKVFERYKRYSPYDLKESIRMEVKGDLEKSFLTL 257
Cdd:pfam00191   2 DAELLRK-AMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
283-332 3.42e-12

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 60.50  E-value: 3.42e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 27762266    283 DKIITRIIVSRCEVDLMKVRIEFKRNFGRSLHQTISEHTKGDYQRALLNL 332
Cdd:smart00335   4 EKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
49-101 4.32e-11

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 57.42  E-value: 4.32e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 27762266     49 GVDEQTIIDILTRRSLLKRSDIAFEYEKRAKKDLVSALKGALSGSLEHLILGL 101
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
205-257 1.83e-09

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 52.79  E-value: 1.83e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 27762266    205 GTDVVTWISIFSERSVSHLQKVFERYKRYSPYDLKESIRMEVKGDLEKSFLTL 257
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH