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Conserved domains on  [gi|23305916|gb|AAN17339|]
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tyrosinase [Danio rerio]

Protein Classification

tyrosinase family protein( domain architecture ID 11026236)

tyrosinase family protein such as tyrosinase, a metal-containing oxidase that catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine

Gene Ontology:  GO:0046872|GO:0016491
PubMed:  29473882|11412044

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tyrosinase pfam00264
Common central domain of tyrosinase; This family also contains polyphenol oxidases and some ...
 172-405 8.84e-42

Common central domain of tyrosinase; This family also contains polyphenol oxidases and some hemocyanins. Binds two copper ions via two sets of three histidines. This family is related to pfam00372.


:

Pssm-ID: 425566  Cd Length: 209  Bit Score: 148.77  E-value: 8.84e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23305916   172 SVYDLFVWMHYYvsrdallggPGNVWAdidfAHESAAFLPWHRVYLLFWEHEIRKLTG--DFNFTIPYWDW-RDAQDCQV 248
Cdd:pfam00264   2 SSYDDFAAIHGI---------PFTPWP----IHGNGLFLPWHRYYLLLFEQALREECGyaDPTGTLPYWDWtDDPTSPGI 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23305916   249 CTDELMG----ARSSLNRSLISPSSVFSSWKVicsqpesYNLREALCDGSPEGPLLRNPGDHDRIRVPRLPTSADVESVL 324
Cdd:pfam00264  69 SSPTSLGgngtFIPPNGGVGEVTNGPFANYTV-------PNLGPHTIRRPPDNALAYNPRCLTRDNPLLKQQLNTLDVVD 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23305916   325 RLTDYetgqmdRRANLSFRNALEGFANPETGLavtgrslMHNSLHVFMNGSMSSVQGSANDPIFIIHHAFIDSIFEQWLR 404
Cdd:pfam00264 142 DLLTY------QPDYTSFSNTLEGDGGNEEGL-------PHNGVHVWVGGDMGDVFTAPNDPIFFLHHANIDRLWAIWQR 208


                  .
gi 23305916   405 R 405
Cdd:pfam00264 209 L 209
EGF_CA super family cl21504
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 89-110 2.05e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


The actual alignment was detected with superfamily member pfam00053:

Pssm-ID: 473889  Cd Length: 49  Bit Score: 36.18  E-value: 2.05e-03
                          10        20
                  ....*....|....*....|..
gi 23305916    89 TCQCAGNYMGFDCGECKFGFFG 110
Cdd:pfam00053  19 QCLCKPGVTGRHCDRCKPGYYG 40
 
Name Accession Description Interval E-value
Tyrosinase pfam00264
Common central domain of tyrosinase; This family also contains polyphenol oxidases and some ...
 172-405 8.84e-42

Common central domain of tyrosinase; This family also contains polyphenol oxidases and some hemocyanins. Binds two copper ions via two sets of three histidines. This family is related to pfam00372.


Pssm-ID: 425566  Cd Length: 209  Bit Score: 148.77  E-value: 8.84e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23305916   172 SVYDLFVWMHYYvsrdallggPGNVWAdidfAHESAAFLPWHRVYLLFWEHEIRKLTG--DFNFTIPYWDW-RDAQDCQV 248
Cdd:pfam00264   2 SSYDDFAAIHGI---------PFTPWP----IHGNGLFLPWHRYYLLLFEQALREECGyaDPTGTLPYWDWtDDPTSPGI 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23305916   249 CTDELMG----ARSSLNRSLISPSSVFSSWKVicsqpesYNLREALCDGSPEGPLLRNPGDHDRIRVPRLPTSADVESVL 324
Cdd:pfam00264  69 SSPTSLGgngtFIPPNGGVGEVTNGPFANYTV-------PNLGPHTIRRPPDNALAYNPRCLTRDNPLLKQQLNTLDVVD 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23305916   325 RLTDYetgqmdRRANLSFRNALEGFANPETGLavtgrslMHNSLHVFMNGSMSSVQGSANDPIFIIHHAFIDSIFEQWLR 404
Cdd:pfam00264 142 DLLTY------QPDYTSFSNTLEGDGGNEEGL-------PHNGVHVWVGGDMGDVFTAPNDPIFFLHHANIDRLWAIWQR 208


                  .
gi 23305916   405 R 405
Cdd:pfam00264 209 L 209
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 89-110 2.05e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 36.18  E-value: 2.05e-03
                          10        20
                  ....*....|....*....|..
gi 23305916    89 TCQCAGNYMGFDCGECKFGFFG 110
Cdd:pfam00053  19 QCLCKPGVTGRHCDRCKPGYYG 40
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
90-113 7.37e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 34.59  E-value: 7.37e-03
                           10        20
                   ....*....|....*....|....
gi 23305916     90 CQCAGNYMGFDCGECKFGFFGANC 113
Cdd:smart00180  20 CECKPNVTGRRCDRCAPGYYGDGP 43
 
Name Accession Description Interval E-value
Tyrosinase pfam00264
Common central domain of tyrosinase; This family also contains polyphenol oxidases and some ...
 172-405 8.84e-42

Common central domain of tyrosinase; This family also contains polyphenol oxidases and some hemocyanins. Binds two copper ions via two sets of three histidines. This family is related to pfam00372.


Pssm-ID: 425566  Cd Length: 209  Bit Score: 148.77  E-value: 8.84e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23305916   172 SVYDLFVWMHYYvsrdallggPGNVWAdidfAHESAAFLPWHRVYLLFWEHEIRKLTG--DFNFTIPYWDW-RDAQDCQV 248
Cdd:pfam00264   2 SSYDDFAAIHGI---------PFTPWP----IHGNGLFLPWHRYYLLLFEQALREECGyaDPTGTLPYWDWtDDPTSPGI 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23305916   249 CTDELMG----ARSSLNRSLISPSSVFSSWKVicsqpesYNLREALCDGSPEGPLLRNPGDHDRIRVPRLPTSADVESVL 324
Cdd:pfam00264  69 SSPTSLGgngtFIPPNGGVGEVTNGPFANYTV-------PNLGPHTIRRPPDNALAYNPRCLTRDNPLLKQQLNTLDVVD 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23305916   325 RLTDYetgqmdRRANLSFRNALEGFANPETGLavtgrslMHNSLHVFMNGSMSSVQGSANDPIFIIHHAFIDSIFEQWLR 404
Cdd:pfam00264 142 DLLTY------QPDYTSFSNTLEGDGGNEEGL-------PHNGVHVWVGGDMGDVFTAPNDPIFFLHHANIDRLWAIWQR 208


                  .
gi 23305916   405 R 405
Cdd:pfam00264 209 L 209
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 89-110 2.05e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 36.18  E-value: 2.05e-03
                          10        20
                  ....*....|....*....|..
gi 23305916    89 TCQCAGNYMGFDCGECKFGFFG 110
Cdd:pfam00053  19 QCLCKPGVTGRHCDRCKPGYYG 40
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
90-113 7.37e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 34.59  E-value: 7.37e-03
                           10        20
                   ....*....|....*....|....
gi 23305916     90 CQCAGNYMGFDCGECKFGFFGANC 113
Cdd:smart00180  20 CECKPNVTGRRCDRCAPGYYGDGP 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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