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Conserved domains on  [gi|23197952|gb|AAN15503|]
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cleavage stimulation factor 50K chain [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 115-426 6.53e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 157.50  E-value: 6.53e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23197952 115 ESKTLSEHKSVVRCARFSPDGMFFATGGADTSIKLFevpkvkqmisgDTQARPLIRTFYDHAEPINDLDFHPRSTILISS 194
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVW-----------DLETGELLRTLKGHTGPVRDVAASADGTYLASG 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23197952 195 AKDNCIKFFDFSKTTAKRAFKvfQDTHNVRSISFHPSGEFLLAGTDHPIPHLYDVNTYQCFlpSNFPdsGVSGAINQVRY 274
Cdd:cd00200  70 SSDKTIRLWDLETGECVRTLT--GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCL--TTLR--GHTDWVNSVAF 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23197952 275 SSTGSIYITASKDGAIRLFDGVSAKCVRSIgNAHgKSEVTSAVFTKDQRFVLSSGKDSTVKLWEIGSGRMVKEYLGaKRV 354
Cdd:cd00200 144 SPDGTFVASSSQDGTIKLWDLRTGKCVATL-TGH-TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG-HEN 220

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 23197952 355 KLRSqAIFNDTEEFVISIDEASNeVVTWDARTADKVAKWPSnHNGAPRWIEHSPVESVFVTCGIDRSIRFWK 426
Cdd:cd00200 221 GVNS-VAFSPDGYLLASGSEDGT-IRVWDLRTGECVQTLSG-HTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 115-426 6.53e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 157.50  E-value: 6.53e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23197952 115 ESKTLSEHKSVVRCARFSPDGMFFATGGADTSIKLFevpkvkqmisgDTQARPLIRTFYDHAEPINDLDFHPRSTILISS 194
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVW-----------DLETGELLRTLKGHTGPVRDVAASADGTYLASG 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23197952 195 AKDNCIKFFDFSKTTAKRAFKvfQDTHNVRSISFHPSGEFLLAGTDHPIPHLYDVNTYQCFlpSNFPdsGVSGAINQVRY 274
Cdd:cd00200  70 SSDKTIRLWDLETGECVRTLT--GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCL--TTLR--GHTDWVNSVAF 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23197952 275 SSTGSIYITASKDGAIRLFDGVSAKCVRSIgNAHgKSEVTSAVFTKDQRFVLSSGKDSTVKLWEIGSGRMVKEYLGaKRV 354
Cdd:cd00200 144 SPDGTFVASSSQDGTIKLWDLRTGKCVATL-TGH-TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG-HEN 220

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 23197952 355 KLRSqAIFNDTEEFVISIDEASNeVVTWDARTADKVAKWPSnHNGAPRWIEHSPVESVFVTCGIDRSIRFWK 426
Cdd:cd00200 221 GVNS-VAFSPDGYLLASGSEDGT-IRVWDLRTGECVQTLSG-HTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
114-425 1.60e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 157.00  E-value: 1.60e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23197952 114 HESKTLSEHKSVVRCARFSPDGMFFATGGADTSIKLFevpkvkqmisgDTQARPLIRTFYDHAEPINDLDFHPRSTILIS 193
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW-----------DLATGKLLRTLTGHSGAVTSVAFSPDGKLLAS 179

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23197952 194 SAKDNCIKFFDFSKTTAKRAFKVfqDTHNVRSISFHPSGEFLLAGTDHPIPHLYDVNTYQCFLPSNFPDSGVSGainqVR 273
Cdd:COG2319 180 GSDDGTVRLWDLATGKLLRTLTG--HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRS----VA 253

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23197952 274 YSSTGSIYITASKDGAIRLFDGVSAKCVRSIGnaHGKSEVTSAVFTKDQRFVLSSGKDSTVKLWEIGSGRMVKEYLGakR 353
Cdd:COG2319 254 FSPDGRLLASGSADGTVRLWDLATGELLRTLT--GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG--H 329

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 23197952 354 VKLRSQAIFNDTEEFVISideAS--NEVVTWDARTADKVAKWpSNHNGAPRWIEHSPVESVFVTCGIDRSIRFW 425
Cdd:COG2319 330 TGAVRSVAFSPDGKTLAS---GSddGTVRLWDLATGELLRTL-TGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 112-151 2.73e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 2.73e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 23197952    112 PKHESKTLSEHKSVVRCARFSPDGMFFATGGADTSIKLFE 151
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
117-151 6.26e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 6.26e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 23197952   117 KTLSEHKSVVRCARFSPDGMFFATGGADTSIKLFE 151
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 178-339 3.16e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 39.88  E-value: 3.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23197952  178 PINDLDFHP-RSTILISSAKDNCIKFFD-----FSKTTAKRAFKVFQDTHNVRSISFHPSGEFLLA--GTDHPIpHLYDV 249
Cdd:PTZ00421  77 PIIDVAFNPfDPQKLFTASEDGTIMGWGipeegLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLAsaGADMVV-NVWDV 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23197952  250 NTyqcflpsnfpdsGVSGA--------INQVRYSSTGSIYITASKDGAIRLFDGVSAKCVRSIGnAHGKSEVTSAVFTKD 321
Cdd:PTZ00421 156 ER------------GKAVEvikchsdqITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLWAKR 222

                        170       180
                 ....*....|....*....|..
gi 23197952  322 QRFVLSSG----KDSTVKLWEI 339
Cdd:PTZ00421 223 KDLIITLGcsksQQRQIMLWDT 244
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 115-426 6.53e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 157.50  E-value: 6.53e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23197952 115 ESKTLSEHKSVVRCARFSPDGMFFATGGADTSIKLFevpkvkqmisgDTQARPLIRTFYDHAEPINDLDFHPRSTILISS 194
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVW-----------DLETGELLRTLKGHTGPVRDVAASADGTYLASG 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23197952 195 AKDNCIKFFDFSKTTAKRAFKvfQDTHNVRSISFHPSGEFLLAGTDHPIPHLYDVNTYQCFlpSNFPdsGVSGAINQVRY 274
Cdd:cd00200  70 SSDKTIRLWDLETGECVRTLT--GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCL--TTLR--GHTDWVNSVAF 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23197952 275 SSTGSIYITASKDGAIRLFDGVSAKCVRSIgNAHgKSEVTSAVFTKDQRFVLSSGKDSTVKLWEIGSGRMVKEYLGaKRV 354
Cdd:cd00200 144 SPDGTFVASSSQDGTIKLWDLRTGKCVATL-TGH-TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG-HEN 220

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 23197952 355 KLRSqAIFNDTEEFVISIDEASNeVVTWDARTADKVAKWPSnHNGAPRWIEHSPVESVFVTCGIDRSIRFWK 426
Cdd:cd00200 221 GVNS-VAFSPDGYLLASGSEDGT-IRVWDLRTGECVQTLSG-HTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
114-425 1.60e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 157.00  E-value: 1.60e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23197952 114 HESKTLSEHKSVVRCARFSPDGMFFATGGADTSIKLFevpkvkqmisgDTQARPLIRTFYDHAEPINDLDFHPRSTILIS 193
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW-----------DLATGKLLRTLTGHSGAVTSVAFSPDGKLLAS 179

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23197952 194 SAKDNCIKFFDFSKTTAKRAFKVfqDTHNVRSISFHPSGEFLLAGTDHPIPHLYDVNTYQCFLPSNFPDSGVSGainqVR 273
Cdd:COG2319 180 GSDDGTVRLWDLATGKLLRTLTG--HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRS----VA 253

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23197952 274 YSSTGSIYITASKDGAIRLFDGVSAKCVRSIGnaHGKSEVTSAVFTKDQRFVLSSGKDSTVKLWEIGSGRMVKEYLGakR 353
Cdd:COG2319 254 FSPDGRLLASGSADGTVRLWDLATGELLRTLT--GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG--H 329

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 23197952 354 VKLRSQAIFNDTEEFVISideAS--NEVVTWDARTADKVAKWpSNHNGAPRWIEHSPVESVFVTCGIDRSIRFW 425
Cdd:COG2319 330 TGAVRSVAFSPDGKTLAS---GSddGTVRLWDLATGELLRTL-TGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
117-341 1.16e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.81  E-value: 1.16e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23197952 117 KTLSEHKSVVRCARFSPDGMFFATGGADTSIKLFevpkvkqmisgDTQARPLIRTFYDHAEPINDLDFHPRSTILISSAK 196
Cdd:COG2319 198 RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW-----------DLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSA 266

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23197952 197 DNCIKFFDFSKTTAKRAFKvfQDTHNVRSISFHPSGEFLLAGTDHPIPHLYDVNTYQCFlpsnFPDSGVSGAINQVRYSS 276
Cdd:COG2319 267 DGTVRLWDLATGELLRTLT--GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL----RTLTGHTGAVRSVAFSP 340

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 23197952 277 TGSIYITASKDGAIRLFDGVSAKCVRSIgNAHGkSEVTSAVFTKDQRFVLSSGKDSTVKLWEIGS 341
Cdd:COG2319 341 DGKTLASGSDDGTVRLWDLATGELLRTL-TGHT-GAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 114-338 1.60e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 124.37  E-value: 1.60e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23197952 114 HESKTLSEHKSVVRCARFSPDGMFFATGGADTSIKLFEVPKVKQmisgdtqarplIRTFYDHAEPINDLDFHPRSTILIS 193
Cdd:cd00200  84 ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKC-----------LTTLRGHTDWVNSVAFSPDGTFVAS 152

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23197952 194 SAKDNCIKFFDFSKTTAKRAFKVFQDthNVRSISFHPSGE-FLLAGTDHPIpHLYDVNTYQCF--LpsnfpdSGVSGAIN 270
Cdd:cd00200 153 SSQDGTIKLWDLRTGKCVATLTGHTG--EVNSVAFSPDGEkLLSSSSDGTI-KLWDLSTGKCLgtL------RGHENGVN 223

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 23197952 271 QVRYSSTGSIYITASKDGAIRLFDGVSAKCVRSIGnAHgKSEVTSAVFTKDQRFVLSSGKDSTVKLWE 338
Cdd:cd00200 224 SVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLS-GH-TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 113-204 2.61e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.81  E-value: 2.61e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23197952 113 KHESKTLSEHKSVVRCARFSPDGMFFATGGADTSIKLFevpkvkqmisgDTQARPLIRTFYDHAEPINDLDFHPRSTILI 192
Cdd:cd00200 209 GKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW-----------DLRTGECVQTLSGHTNSVTSLAWSPDGKRLA 277

                        90
                ....*....|..
gi 23197952 193 SSAKDNCIKFFD 204
Cdd:cd00200 278 SGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 112-151 2.73e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 2.73e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 23197952    112 PKHESKTLSEHKSVVRCARFSPDGMFFATGGADTSIKLFE 151
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 168-204 4.42e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 4.42e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 23197952    168 LIRTFYDHAEPINDLDFHPRSTILISSAKDNCIKFFD 204
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
117-151 6.26e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 6.26e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 23197952   117 KTLSEHKSVVRCARFSPDGMFFATGGADTSIKLFE 151
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
168-204 2.20e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.20e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 23197952   168 LIRTFYDHAEPINDLDFHPRSTILISSAKDNCIKFFD 204
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 117-339 4.76e-05

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 45.06  E-value: 4.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23197952   117 KTLSEHKSVVRCARFSPDGMFFATGGADTSIKLFEVPKVKqmiSGDTQARPLIRTFYDHAEPINDLDFH----------- 185
Cdd:pfam20426 118 QSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGR---SSEKRSRNTQTEFPRKDHVIAETPFHilcghddiitc 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23197952   186 ----PRSTILISSAKD-NCIkffdfskttakraFKVFQDTHNVRSISfHPSGEFL--LAGTDHPIP----------HLYD 248
Cdd:pfam20426 195 lyvsVELDIVISGSKDgTCI-------------FHTLREGRYVRSIR-HPSGCPLskLVASRHGRIvlyadddlslHLYS 260

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23197952   249 VNTYQcfLPSnfpdSGVSGAINQVRYSSTGSIYITASKDGAIRLFDGVSAKCVRSIGNAhGKSeVTSAVFTKDQRFvLSS 328
Cdd:pfam20426 261 INGKH--IAS----SESNGRLNCIELSSCGEFLVCAGDQGQIVVRSMNSLEVVRRYNGI-GKI-ITSLTVTPEECF-LAG 331

                         250
                  ....*....|.
gi 23197952   329 GKDSTVKLWEI 339
Cdd:pfam20426 332 TKDGSLLVYSI 342
WD40 COG2319
WD40 repeat [General function prediction only];
115-153 2.23e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 43.36  E-value: 2.23e-04
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 23197952 115 ESKTLSEHKSVVRCARFSPDGMFFATGGADTSIKLFEVP 153
Cdd:COG2319 364 LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 pfam00400
WD domain, G-beta repeat;
299-338 2.42e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 2.42e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 23197952   299 KCVRSIgNAHgKSEVTSAVFTKDQRFVLSSGKDSTVKLWE 338
Cdd:pfam00400   2 KLLKTL-EGH-TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 297-338 2.82e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 2.82e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 23197952    297 SAKCVRSIgNAHgKSEVTSAVFTKDQRFVLSSGKDSTVKLWE 338
Cdd:smart00320   1 SGELLKTL-KGH-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 178-339 3.16e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 39.88  E-value: 3.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23197952  178 PINDLDFHP-RSTILISSAKDNCIKFFD-----FSKTTAKRAFKVFQDTHNVRSISFHPSGEFLLA--GTDHPIpHLYDV 249
Cdd:PTZ00421  77 PIIDVAFNPfDPQKLFTASEDGTIMGWGipeegLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLAsaGADMVV-NVWDV 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23197952  250 NTyqcflpsnfpdsGVSGA--------INQVRYSSTGSIYITASKDGAIRLFDGVSAKCVRSIGnAHGKSEVTSAVFTKD 321
Cdd:PTZ00421 156 ER------------GKAVEvikchsdqITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLWAKR 222

                        170       180
                 ....*....|....*....|..
gi 23197952  322 QRFVLSSG----KDSTVKLWEI 339
Cdd:PTZ00421 223 KDLIITLGcsksQQRQIMLWDT 244
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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