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Conserved domains on  [gi|383291314|gb|AAN10345|]
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lethal (2) k05819, isoform C [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MgtA super family cl43151
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
551-669 1.48e-04

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


The actual alignment was detected with superfamily member COG0474:

Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 46.25  E-value: 1.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383291314  551 GFTDHATDRFALEGQLASYRHLQPDVVRRD------IRFARQLQLS--------SKVK-VPF-PHS--LSVVMRENPGGY 612
Cdd:COG0474   355 GEFDPALEELLRAAALCSDAQLEEETGLGDptegalLVAAAKAGLDveelrkeyPRVDeIPFdSERkrMSTVHEDPDGKR 434
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 383291314  613 LsLFTQGTADIILDCCDDFWDGIDLRPLSAQDRKRALDFYQRSA------LtsyctAFAYRPL 669
Cdd:COG0474   435 L-LIVKGAPEVVLALCTRVLTGGGVVPLTEEDRAEILEAVEELAaqglrvL-----AVAYKEL 491
Cation_ATPase_C super family cl47165
Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
1224-1407 1.82e-03

Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.


The actual alignment was detected with superfamily member pfam00689:

Pssm-ID: 376368 [Multi-domain]  Cd Length: 175  Bit Score: 40.69  E-value: 1.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383291314  1224 PLIAISLAHIDVDPKIMNRAT-SKKQTDYDSRAFAFVMWcYGckFIVLVVSLLVSYWMLLPNTqlnpaepateepvleid 1302
Cdd:pfam00689   18 GLPALALGFEPPEPDLMKRPPrKPKEPLFSRKMLRRILL-QG--LLIAILTLLVFFLGLLGFG----------------- 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383291314  1303 ddddpefYQFLYIARSSALLGIILHFVFISVTFVHRDHALWQRNPFTNR--IWAFtcLFLVLIHGIICFVQLLLEDFWVQ 1380
Cdd:pfam00689   78 -------ISESQNAQTMAFNTLVLSQLFNALNARSLRRSLFKIGLFSNKllLLAI--LLSLLLQLLIIYVPPLQAVFGTT 148
                          170       180
                   ....*....|....*....|....*....
gi 383291314  1381 LPN--QWLALLILfggSLLSMLVSELAKF 1407
Cdd:pfam00689  149 PLSleQWLIVLLL---ALVVLLVVELRKL 174
 
Name Accession Description Interval E-value
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
551-669 1.48e-04

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 46.25  E-value: 1.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383291314  551 GFTDHATDRFALEGQLASYRHLQPDVVRRD------IRFARQLQLS--------SKVK-VPF-PHS--LSVVMRENPGGY 612
Cdd:COG0474   355 GEFDPALEELLRAAALCSDAQLEEETGLGDptegalLVAAAKAGLDveelrkeyPRVDeIPFdSERkrMSTVHEDPDGKR 434
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 383291314  613 LsLFTQGTADIILDCCDDFWDGIDLRPLSAQDRKRALDFYQRSA------LtsyctAFAYRPL 669
Cdd:COG0474   435 L-LIVKGAPEVVLALCTRVLTGGGVVPLTEEDRAEILEAVEELAaqglrvL-----AVAYKEL 491
Cation_ATPase_C pfam00689
Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
1224-1407 1.82e-03

Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.


Pssm-ID: 376368 [Multi-domain]  Cd Length: 175  Bit Score: 40.69  E-value: 1.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383291314  1224 PLIAISLAHIDVDPKIMNRAT-SKKQTDYDSRAFAFVMWcYGckFIVLVVSLLVSYWMLLPNTqlnpaepateepvleid 1302
Cdd:pfam00689   18 GLPALALGFEPPEPDLMKRPPrKPKEPLFSRKMLRRILL-QG--LLIAILTLLVFFLGLLGFG----------------- 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383291314  1303 ddddpefYQFLYIARSSALLGIILHFVFISVTFVHRDHALWQRNPFTNR--IWAFtcLFLVLIHGIICFVQLLLEDFWVQ 1380
Cdd:pfam00689   78 -------ISESQNAQTMAFNTLVLSQLFNALNARSLRRSLFKIGLFSNKllLLAI--LLSLLLQLLIIYVPPLQAVFGTT 148
                          170       180
                   ....*....|....*....|....*....
gi 383291314  1381 LPN--QWLALLILfggSLLSMLVSELAKF 1407
Cdd:pfam00689  149 PLSleQWLIVLLL---ALVVLLVVELRKL 174
 
Name Accession Description Interval E-value
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
551-669 1.48e-04

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 46.25  E-value: 1.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383291314  551 GFTDHATDRFALEGQLASYRHLQPDVVRRD------IRFARQLQLS--------SKVK-VPF-PHS--LSVVMRENPGGY 612
Cdd:COG0474   355 GEFDPALEELLRAAALCSDAQLEEETGLGDptegalLVAAAKAGLDveelrkeyPRVDeIPFdSERkrMSTVHEDPDGKR 434
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 383291314  613 LsLFTQGTADIILDCCDDFWDGIDLRPLSAQDRKRALDFYQRSA------LtsyctAFAYRPL 669
Cdd:COG0474   435 L-LIVKGAPEVVLALCTRVLTGGGVVPLTEEDRAEILEAVEELAaqglrvL-----AVAYKEL 491
Cation_ATPase_C pfam00689
Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
1224-1407 1.82e-03

Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.


Pssm-ID: 376368 [Multi-domain]  Cd Length: 175  Bit Score: 40.69  E-value: 1.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383291314  1224 PLIAISLAHIDVDPKIMNRAT-SKKQTDYDSRAFAFVMWcYGckFIVLVVSLLVSYWMLLPNTqlnpaepateepvleid 1302
Cdd:pfam00689   18 GLPALALGFEPPEPDLMKRPPrKPKEPLFSRKMLRRILL-QG--LLIAILTLLVFFLGLLGFG----------------- 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383291314  1303 ddddpefYQFLYIARSSALLGIILHFVFISVTFVHRDHALWQRNPFTNR--IWAFtcLFLVLIHGIICFVQLLLEDFWVQ 1380
Cdd:pfam00689   78 -------ISESQNAQTMAFNTLVLSQLFNALNARSLRRSLFKIGLFSNKllLLAI--LLSLLLQLLIIYVPPLQAVFGTT 148
                          170       180
                   ....*....|....*....|....*....
gi 383291314  1381 LPN--QWLALLILfggSLLSMLVSELAKF 1407
Cdd:pfam00689  149 PLSleQWLIVLLL---ALVVLLVVELRKL 174
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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