NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|45445390|gb|AAM68271|]
View 

pippin [Drosophila melanogaster]

Protein Classification

sugar porter family MFS transporter( domain architecture ID 13024188)

sugar porter family major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of sugar or polyol substrates such as glucose, galactose, trehalose, and arabinose, among others

CATH:  1.20.1250.20
SCOP:  3000310
TCDB:  2.A.1.1

Graphical summary

 Zoom to residue level

show extra options Â»

Show site features     Horizontal zoom: Ã—

List of domain hits

Name Accession Description Interval E-value
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
59-495 1.20e-152

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 443.56  E-value: 1.20e-152
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  59 ILATCAVLLLSAGCGMPIGFSAILLPQLMDNNSTEIPIDVETGSWIASVHSLATPFGSLLSGPLADYLGRRRTLILSVIP 138
Cdd:cd17358   1 LLATFVANLGSFSFGIAVGWSSPALPSLMSDNSLSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIP 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 139 LLLGWSTLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETAEPNLRSLLIGAPYVAYSSGILMVYSLGSMMYWRSVAW 218
Cdd:cd17358  81 CILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFLPWRTLAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 219 CANVLPLLSMVSISFIPETPAWLLRNGHEKRALQALSFLRGSEISAQKELNDMKQRLAKERVTTKtnENIFQLCCQRVAI 298
Cdd:cd17358 161 IGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSLQFLRGKDADISKEAAEIQEELAELEKEAK--ESSFSDLFQRKYL 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 299 KPLVIVIVFSLLQMFSGTFIVIFYAVDMISEFGAEFDSKQAAIATAVVRVICCMVFCVVLIFVRRRRIMIVSGIGSGLFC 378
Cdd:cd17358 239 KPLVIGLGLMLFQQLSGINAVIFYASSIFDEAGSGLDPNTATIIIGVVQVVGTLVATLLVDRLGRRPLLLVSAIGMGIGL 318
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 379 LVLSVYQYARFD-QPKMSYDVFVGAGCLLGYIIFNTALMVMPGIMIGELFPARIRGRTAGGVFASMNVALFIFAKKFPAL 457
Cdd:cd17358 319 LALGLYFYLQEHgALLSSVSWLPLVGLVIYIISFSIGLGPLPWVIMSEIFPAKIKGLAGSLVTLVNWLFAFIVTKTFPFL 398
                       410       420       430
                ....*....|....*....|....*....|....*...
gi 45445390 458 QAMLKMRGVFLVFGVSSFLLTAFMCLFQPETKGRSLEH 495
Cdd:cd17358 399 TLAWGASGTFWIFAGICGLALVFVLLFVPETKGKSLEE 436
 
Name Accession Description Interval E-value
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
59-495 1.20e-152

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 443.56  E-value: 1.20e-152
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  59 ILATCAVLLLSAGCGMPIGFSAILLPQLMDNNSTEIPIDVETGSWIASVHSLATPFGSLLSGPLADYLGRRRTLILSVIP 138
Cdd:cd17358   1 LLATFVANLGSFSFGIAVGWSSPALPSLMSDNSLSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIP 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 139 LLLGWSTLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETAEPNLRSLLIGAPYVAYSSGILMVYSLGSMMYWRSVAW 218
Cdd:cd17358  81 CILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFLPWRTLAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 219 CANVLPLLSMVSISFIPETPAWLLRNGHEKRALQALSFLRGSEISAQKELNDMKQRLAKERVTTKtnENIFQLCCQRVAI 298
Cdd:cd17358 161 IGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSLQFLRGKDADISKEAAEIQEELAELEKEAK--ESSFSDLFQRKYL 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 299 KPLVIVIVFSLLQMFSGTFIVIFYAVDMISEFGAEFDSKQAAIATAVVRVICCMVFCVVLIFVRRRRIMIVSGIGSGLFC 378
Cdd:cd17358 239 KPLVIGLGLMLFQQLSGINAVIFYASSIFDEAGSGLDPNTATIIIGVVQVVGTLVATLLVDRLGRRPLLLVSAIGMGIGL 318
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 379 LVLSVYQYARFD-QPKMSYDVFVGAGCLLGYIIFNTALMVMPGIMIGELFPARIRGRTAGGVFASMNVALFIFAKKFPAL 457
Cdd:cd17358 319 LALGLYFYLQEHgALLSSVSWLPLVGLVIYIISFSIGLGPLPWVIMSEIFPAKIKGLAGSLVTLVNWLFAFIVTKTFPFL 398
                       410       420       430
                ....*....|....*....|....*....|....*...
gi 45445390 458 QAMLKMRGVFLVFGVSSFLLTAFMCLFQPETKGRSLEH 495
Cdd:cd17358 399 TLAWGASGTFWIFAGICGLALVFVLLFVPETKGKSLEE 436
Sugar_tr pfam00083
Sugar (and other) transporter;
89-497 4.51e-43

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 159.36  E-value: 4.51e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390    89 NNSTEIPIDVETGsWIASVHSLATPFGSLLSGPLADYLGRRRTLI----LSVIP-LLLGWSTlaIAKSIKVVIFARFLCG 163
Cdd:pfam00083  37 SVSSLAALSVLSG-LIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLianvLFVIGaVLQGAAK--GKWSVYQLIVGRVLVG 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390   164 FATGILGGPGQVYIAETAEPNLRSLLIGAPYVAYSSGILMVY--SLGSMMYWRSVAWC-----ANVLPLLSMVSISFIPE 236
Cdd:pfam00083 114 IGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYifGLGLNKTSNSDGWRiplglQLVPALLLIIGLLFLPE 193
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390   237 TPAWLLRNGHEKRALQALSFLRGSEiSAQKELNDMKQRLAKERVTTKTNENIFQLCCQRVaiKPLVIVIVFSLLQMFSGT 316
Cdd:pfam00083 194 SPRWLVEKGRLEEAREVLAKLRGVP-DVDRELDEIKDSLEAGQEAEKASWKELFSTKTRR--QRLLIGVMLQIFQQLTGI 270
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390   317 FIVIFYAVDMISEFGAEfDSKQAAIATAVVRviccMVFCVVLIFVR----RRRIMIVSGIGSGLFCLVLSVYQYARFDQP 392
Cdd:pfam00083 271 NAIFYYSTTIFENLGLS-DSFLVTIIVGVVN----FVFTFIAIFLVdrfgRRPLLLLGAAGMAICFVILGIVALLGVSKS 345
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390   393 KmSYDVFVGAGCLLGYIIFNTALMVMPGIMIGELFPARIRGRTAGGVFASMNVALFIFAKKFPALQAMLKMRGVFLVFGV 472
Cdd:pfam00083 346 D-WAGIVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIGLGYTFFIFAG 424
                         410       420
                  ....*....|....*....|....*
gi 45445390   473 SSFLLTAFMCLFQPETKGRSLEHIE 497
Cdd:pfam00083 425 LLVLFIIFVFFFVPETKGRTLEEID 449
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
102-496 5.99e-38

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 145.56  E-value: 5.99e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390   102 SWIASVHSLATPFGSLLSGPLADYLGRRRTLILSVIPLLLGW---STLAIAKSIKVVIFARFLCGFATGILGGPGQVYIA 178
Cdd:TIGR00879  74 GLVVSIFLVGGFIGALFAGWLSDRFGRKKSLLIIALLFVIGAilmGLAAFALSVEMLIVGRVLLGIGVGIASALVPMYLS 153
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390   179 ETAEPNLRSLLIGAPYVAYSSGILMVYSLGSM--MYWRSVAWCAN-----VLPLLSMVSISFIPETPAWLLRNGHEKRAL 251
Cdd:TIGR00879 154 EIAPKALRGALTSLYQLAITFGILVAYGFGSGkvSLNNTLGWRIPlglqlIPAGLLFLGLFFLPESPRWLVGKGRVEEAR 233
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390   252 QALSFLRGSEISAQKELnDMKQRLAKERVTTKTNENIFQLC---CQRVAIKPLVIVIVFSLLQMFSGTFIVIFYAVDMIS 328
Cdd:TIGR00879 234 KSLARLRGTSGEDKELL-DELELIDIKRSIEKRSVQPSWGSlfsSTRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFE 312
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390   329 EFGaeFDSKQAAIATAVVRVI-CCMVFCVVLIFVR--RRRIMIVSGIGSGLFCLVLS--VYQYARFDQPKMSYdVFVGAG 403
Cdd:TIGR00879 313 NAG--VSTDHAFLVSIIVGAVnFAFTFVAIFLVDRfgRRPLLLIGAAGMAICLFVLGilGASFVTGSSKSSGN-VAIVFI 389
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390   404 CLLGyIIFNTALMVMPGIMIGELFPARIRGRTAGGVFASMNVALFIFAKKFPALQAMLKMRGVFLVFGVSSFLLTAFMCL 483
Cdd:TIGR00879 390 LLFI-AFFAMGWGPVPWVIVSEIFPLSLRPKGISIAVAANWLANFIVGFLFPTMLESIGVGGVFIFFGGLNVLGLIFVYF 468
                         410
                  ....*....|...
gi 45445390   484 FQPETKGRSLEHI 496
Cdd:TIGR00879 469 FLPETKGRTLEEI 481
xylE PRK10077
D-xylose transporter XylE; Provisional
115-501 9.48e-28

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 116.33  E-value: 9.48e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  115 GSLLSGPLADYLGRRRTLILSVIPLLLG-----WSTLAIAKS--------IKVVIFaRFLCGFATGILGGPGQVYIAETA 181
Cdd:PRK10077  71 GGALGGYCSNRFGRRDSLKIAAVLFFISalgsaWPEFGFTSIgpdntgyvPEFVIY-RIIGGIGVGLASMLSPMYIAEIA 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  182 EPNLRSLLIGAPYVAYSSGILMVYSL-------GSMMYWRSVAW----CANVLP-LLSMVSISFIPETPAWLLRNGHEKR 249
Cdd:PRK10077 150 PAHIRGKLVSFNQFAIIFGQLVVYFVnyfiarsGDASWLNTDGWrymfASEAIPaLLFLMLLYFVPETPRYLMSRGKQEQ 229
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  250 ALQALSFLRGSEiSAQKELNDMKQRLAKERVTTktnENIFQLccqrvAIKPLVIVIVFSLLQMFSGTFIVIFYAVDMISE 329
Cdd:PRK10077 230 AEGILRKIMGNT-LATQALQEIKHSLDHGRKTG---GKLLMF-----GVGVIVIGVMLSVFQQFVGINVVLYYAPEIFKT 300
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  330 FGAEFDSkqAAIATAVVRVICcMVFCVVLIFV----RRRRIMIVSGIGSGLFCLVLSVYQYARFdqpkmsydvfVGAGCL 405
Cdd:PRK10077 301 LGASTDI--ALLQTIIVGVIN-LTFTVLAIMTvdkfGRKPLQIIGALGMAIGMFSLGTAFYTQA----------PGIVAL 367
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  406 LGYIIFNTALMVMPG----IMIGELFPARIRGRTAGGVFASMNVALFIFAKKFPALQAMLKMRGVF------LVFGVSSF 475
Cdd:PRK10077 368 LSMLFYVAAFAMSWGpvcwVLLSEIFPNAIRGKALAIAVAAQWIANYFVSWTFPMMDKNSWLVAHFhngfsyWIYGCMGV 447
                        410       420
                 ....*....|....*....|....*.
gi 45445390  476 LLTAFMCLFQPETKGRSLEHIEDYFN 501
Cdd:PRK10077 448 LAALFMWKFVPETKGKTLEEMEALWE 473
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
57-446 1.98e-21

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 95.81  E-value: 1.98e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  57 HQILATCAVLLLSAGCGMPIGFSAILLPQLMDnnstEIPIDVETGSWIASVHSLATPFGSLLSGPLADYLGRRRTLILSV 136
Cdd:COG2814   7 RRWLALLALALGAFLSGLGIGIVLPALPLIAA----DLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 137 IPLLLGWSTLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETAEPNLRSLLIGAPYVAYSSGILMVYSLGSMMY---- 212
Cdd:COG2814  83 LLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAdlfg 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 213 WRSVAWCANVLPLLSMVSISF-IPETPAwllrnghekralqalsFLRGSEISAQKELndmkqrlakervttktnenifql 291
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRlLPESRP----------------AARARLRGSLREL----------------------- 203
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 292 ccqrVAIKPLVIVIVFSLLQMFSGTFIVIFYAVDMISEFGaeFDSKQAAIATAVVrVICCMVFCVVLIF----VRRRRIM 367
Cdd:COG2814 204 ----LRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLG--LSASAAGLLLALF-GLGGVLGALLAGRladrFGRRRLL 276
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 45445390 368 IVSGIGSGLFCLVLSVYQyarfdqpkmSYDVFVGAGCLLGyiIFNTALMVMPGIMIGELFPARIRGRTAGGVFASMNVA 446
Cdd:COG2814 277 LIGLLLLALGLLLLALAG---------SLWLLLLALFLLG--FGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
 
Name Accession Description Interval E-value
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
59-495 1.20e-152

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 443.56  E-value: 1.20e-152
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  59 ILATCAVLLLSAGCGMPIGFSAILLPQLMDNNSTEIPIDVETGSWIASVHSLATPFGSLLSGPLADYLGRRRTLILSVIP 138
Cdd:cd17358   1 LLATFVANLGSFSFGIAVGWSSPALPSLMSDNSLSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIP 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 139 LLLGWSTLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETAEPNLRSLLIGAPYVAYSSGILMVYSLGSMMYWRSVAW 218
Cdd:cd17358  81 CILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFLPWRTLAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 219 CANVLPLLSMVSISFIPETPAWLLRNGHEKRALQALSFLRGSEISAQKELNDMKQRLAKERVTTKtnENIFQLCCQRVAI 298
Cdd:cd17358 161 IGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSLQFLRGKDADISKEAAEIQEELAELEKEAK--ESSFSDLFQRKYL 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 299 KPLVIVIVFSLLQMFSGTFIVIFYAVDMISEFGAEFDSKQAAIATAVVRVICCMVFCVVLIFVRRRRIMIVSGIGSGLFC 378
Cdd:cd17358 239 KPLVIGLGLMLFQQLSGINAVIFYASSIFDEAGSGLDPNTATIIIGVVQVVGTLVATLLVDRLGRRPLLLVSAIGMGIGL 318
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 379 LVLSVYQYARFD-QPKMSYDVFVGAGCLLGYIIFNTALMVMPGIMIGELFPARIRGRTAGGVFASMNVALFIFAKKFPAL 457
Cdd:cd17358 319 LALGLYFYLQEHgALLSSVSWLPLVGLVIYIISFSIGLGPLPWVIMSEIFPAKIKGLAGSLVTLVNWLFAFIVTKTFPFL 398
                       410       420       430
                ....*....|....*....|....*....|....*...
gi 45445390 458 QAMLKMRGVFLVFGVSSFLLTAFMCLFQPETKGRSLEH 495
Cdd:cd17358 399 TLAWGASGTFWIFAGICGLALVFVLLFVPETKGKSLEE 436
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
60-494 2.02e-47

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 170.06  E-value: 2.02e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  60 LATCAVLLLSAGCGMPIGFSAILLPQLMDNNSTEIPIDVETGSWIASVHSLATPFGSLLSGPLADYLGRRRTLILSVIPL 139
Cdd:cd17433   2 LATFAAVLGPLSFGFVLGYSSPAIPSLQRIADPALRLDDAAASWFGSVVTLGAAAGGVLGGWIVDRAGRKLSLMLCSVPF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 140 LLGWSTLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETAEPNLRSLLIGAPYVAYSSGILMVYSLGSMMYWRSVAWC 219
Cdd:cd17433  82 IAGFTVITAAQNVWMLYVGRLLTGLASGVTSLVVPVYISEIAHPRVRGTLGSCVQLMVVIGIMGAYLAGLVLDWRWLAVL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 220 ANVLPLLSMVSISFIPETPAWLLRNGHEKRALQALSFLRGSEISAQKELNDMKQRLAKERVTTKTNEnifqlCCQRVAIK 299
Cdd:cd17433 162 GSIPPTLMLLLMCFMPETPRFLLTQHRRQEAMAALRFLRGPDQGWEWECIGIEQSFHLEEQSFSLAL-----LKQPGIYK 236
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 300 PLVIVIVFSLLQMFSGTFIVIFYAVDMISEfgAEF-DSKQAAIATAVVRVICCMVFCVVLIFVRRRRIMIVSGIgsgLFC 378
Cdd:cd17433 237 PLIIGVSLMAFQQLTGINAVMFYAETIFEE--AKFkDSSVASVIVAAIQVLFTAVAALIMDRAGRKVLLVLSGV---VMV 311
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 379 LVLSVYQYARFDqpkmSYDVFVgAGCLLGYiifntalMVMPGIMIGELFPARIRGRTAGGVFASMNVALFIFAKKFPALQ 458
Cdd:cd17433 312 FSTAAFGWLAVG----SMGFFI-AGFAVGW-------GPIPWLVMSEIFPLHVRGVASGICVLTNWLMAFLVTKEFSSLM 379
                       410       420       430
                ....*....|....*....|....*....|....*.
gi 45445390 459 AMLKMRGVFLVFGVSSFLLTAFMCLFQPETKGRSLE 494
Cdd:cd17433 380 EVLSSYGTFWLFSAFCAFSVLFTLFCVPETKGKTLE 415
Sugar_tr pfam00083
Sugar (and other) transporter;
89-497 4.51e-43

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 159.36  E-value: 4.51e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390    89 NNSTEIPIDVETGsWIASVHSLATPFGSLLSGPLADYLGRRRTLI----LSVIP-LLLGWSTlaIAKSIKVVIFARFLCG 163
Cdd:pfam00083  37 SVSSLAALSVLSG-LIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLianvLFVIGaVLQGAAK--GKWSVYQLIVGRVLVG 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390   164 FATGILGGPGQVYIAETAEPNLRSLLIGAPYVAYSSGILMVY--SLGSMMYWRSVAWC-----ANVLPLLSMVSISFIPE 236
Cdd:pfam00083 114 IGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYifGLGLNKTSNSDGWRiplglQLVPALLLIIGLLFLPE 193
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390   237 TPAWLLRNGHEKRALQALSFLRGSEiSAQKELNDMKQRLAKERVTTKTNENIFQLCCQRVaiKPLVIVIVFSLLQMFSGT 316
Cdd:pfam00083 194 SPRWLVEKGRLEEAREVLAKLRGVP-DVDRELDEIKDSLEAGQEAEKASWKELFSTKTRR--QRLLIGVMLQIFQQLTGI 270
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390   317 FIVIFYAVDMISEFGAEfDSKQAAIATAVVRviccMVFCVVLIFVR----RRRIMIVSGIGSGLFCLVLSVYQYARFDQP 392
Cdd:pfam00083 271 NAIFYYSTTIFENLGLS-DSFLVTIIVGVVN----FVFTFIAIFLVdrfgRRPLLLLGAAGMAICFVILGIVALLGVSKS 345
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390   393 KmSYDVFVGAGCLLGYIIFNTALMVMPGIMIGELFPARIRGRTAGGVFASMNVALFIFAKKFPALQAMLKMRGVFLVFGV 472
Cdd:pfam00083 346 D-WAGIVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIGLGYTFFIFAG 424
                         410       420
                  ....*....|....*....|....*
gi 45445390   473 SSFLLTAFMCLFQPETKGRSLEHIE 497
Cdd:pfam00083 425 LLVLFIIFVFFFVPETKGRTLEEID 449
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
102-496 5.99e-38

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 145.56  E-value: 5.99e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390   102 SWIASVHSLATPFGSLLSGPLADYLGRRRTLILSVIPLLLGW---STLAIAKSIKVVIFARFLCGFATGILGGPGQVYIA 178
Cdd:TIGR00879  74 GLVVSIFLVGGFIGALFAGWLSDRFGRKKSLLIIALLFVIGAilmGLAAFALSVEMLIVGRVLLGIGVGIASALVPMYLS 153
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390   179 ETAEPNLRSLLIGAPYVAYSSGILMVYSLGSM--MYWRSVAWCAN-----VLPLLSMVSISFIPETPAWLLRNGHEKRAL 251
Cdd:TIGR00879 154 EIAPKALRGALTSLYQLAITFGILVAYGFGSGkvSLNNTLGWRIPlglqlIPAGLLFLGLFFLPESPRWLVGKGRVEEAR 233
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390   252 QALSFLRGSEISAQKELnDMKQRLAKERVTTKTNENIFQLC---CQRVAIKPLVIVIVFSLLQMFSGTFIVIFYAVDMIS 328
Cdd:TIGR00879 234 KSLARLRGTSGEDKELL-DELELIDIKRSIEKRSVQPSWGSlfsSTRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFE 312
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390   329 EFGaeFDSKQAAIATAVVRVI-CCMVFCVVLIFVR--RRRIMIVSGIGSGLFCLVLS--VYQYARFDQPKMSYdVFVGAG 403
Cdd:TIGR00879 313 NAG--VSTDHAFLVSIIVGAVnFAFTFVAIFLVDRfgRRPLLLIGAAGMAICLFVLGilGASFVTGSSKSSGN-VAIVFI 389
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390   404 CLLGyIIFNTALMVMPGIMIGELFPARIRGRTAGGVFASMNVALFIFAKKFPALQAMLKMRGVFLVFGVSSFLLTAFMCL 483
Cdd:TIGR00879 390 LLFI-AFFAMGWGPVPWVIVSEIFPLSLRPKGISIAVAANWLANFIVGFLFPTMLESIGVGGVFIFFGGLNVLGLIFVYF 468
                         410
                  ....*....|...
gi 45445390   484 FQPETKGRSLEHI 496
Cdd:TIGR00879 469 FLPETKGRTLEEI 481
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
102-491 2.18e-36

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 140.47  E-value: 2.18e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 102 SWIASVHSLATPFGSLLSGPLADYLGRRRTLILSVIPLLLGwSTLA----IAKSIKVVIFARFLCGFATGILGGPGQVYI 177
Cdd:cd17357  52 SLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVS-SLLMflskSAKSPELLIFGRFLVGIACGLSTGFVPMYL 130
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 178 AETAEPNLRSLLIGAPYVAYSSGIL------MVYSLGSMMYWRSVAWCANVLPLLSMVSISFIPETPAWLLRNGHEK-RA 250
Cdd:cd17357 131 QEISPSELRGALGSLTQIGVTLGILlgqvfgLPSVLGTETLWPYLLFFPGIPALLQLAALPFFPESPKFLLISKGDEeEA 210
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 251 LQALSFLRGSEISAQKELNDMKQRlaKERVTTKTNENIFQLCCQRVAIKPLVIVIVFSLLQMFSGTFIVIFYAVDMISEF 330
Cdd:cd17357 211 EKSLKFLRGIEDDVDQELEEIKKE--SEQMGDQKQVSLMQLLRDPSLRLPLLLVLVVSASQQFSGINAIFFYSTFIFENA 288
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 331 GaeFDSKQAAIATAVVRVICCMVFCVVLIFVR---RRRIMIVSGIGSGLFCLVLSVYQYARFDQPKMSYdvfVGAGCLLG 407
Cdd:cd17357 289 G--FSPQLAEWANLGIGIVNVLSTIVGPFLIEkvgRRPLLLISLSVCAVALLLMSVFLFLSEQNSWMSY---GCIVAIFL 363
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 408 YII-FNTALMVMPGIMIGELFPARIRGRTAGGVFASMNVALFIFAKKFPALQAMLKMrGVFLVFGVSSFLLTAFMCLFQP 486
Cdd:cd17357 364 FIFfFAIGLGPIPWFIGAELFPQAPRSAAQSLGSSVNWTSNFIVGMAFPPLQSIGGG-FVFIIFAIPCALFLLYLYRYLP 442

                ....*
gi 45445390 487 ETKGR 491
Cdd:cd17357 443 ETKGR 447
MFS_GLUT6_Class3 cd17434
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
60-494 7.36e-35

Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340992 [Multi-domain]  Cd Length: 417  Bit Score: 135.73  E-value: 7.36e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  60 LATCAVLLLSAGCGMPIGFSAILLPQLMDNNSTEIPIDVETGSWIASVHSLATPFGSLLSGPLADYLGRRRTLILSVIPL 139
Cdd:cd17434   2 LAVFSAVLGNFSFGYALVYTSPVIPALEQGDDPRLHLNVHQISWFGSVFTLGAAAGGLSAMFLNDRLGRKLSIMFSAVPS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 140 LLGWSTLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETAEPNLRSLLIGAPYVAYSSGILMVYSLGSMMYWRSVAWC 219
Cdd:cd17434  82 ALGYLLMGSAQGIWMLLLGRFLTGFAGGITAASIPVYVSEISHPGVRGALGACPQIMAVFGSLALYALGLLLPWRWLAVA 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 220 ANVLPLLSMVSISFIPETPAWLLRNGHEKRALQALSFLRGSEISAQKELNDMKQRLAKERVTTKTNEnifqlCCQRVAIK 299
Cdd:cd17434 162 GEVPVVIMILLLCFMPNSPRFLISKGKDEKALKALAWLRGPNTDYMTEFEQIKDNIRKQSSRLSWAE-----LKTPSYYK 236
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 300 PLVIVIVFSLLQMFSGTFIVIFYAVDMISEFGAEFDSKQAAIATAVVRVICCMVFCVVLIFVRRRRIMIVSGIgsglfcl 379
Cdd:cd17434 237 PILIAVVMRFLQQLTGITPILVYLEPIFHLTAVILEPKYDAALVGAVRLLSVAIAASLMDKAGRKILLFTSAF------- 309
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 380 vlsvyqyarfdqpkmsydVFVGAGCLLGYIIFNTALMVMPGIMIG----------ELFPARIRGRTAGGVFASMNVALFI 449
Cdd:cd17434 310 ------------------LMFAANLSMGLIPLIAAMLFIMGYAMGwgpitwllmsEILPLKARGVASGLCVVVSWITAFV 371
                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*
gi 45445390 450 FAKKFPALQAMLKMRGVFLVFGVSSFLLTAFMCLFQPETKGRSLE 494
Cdd:cd17434 372 LTQLFLPVVVTFGLQVPFLFFAAVCAVSIIFTACCVPETKGRTLE 416
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
102-496 4.66e-34

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 133.90  E-value: 4.66e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 102 SWIASVHSLATPFGSLLSGPLADYLGRRRTL----ILSVIP-LLLGWSTlaIAKSIKVVIFARFLCGFATGILGGPGQVY 176
Cdd:cd17432  53 SLTVSIFPLGGLFGSLLVGPLVIRLGRKGTLllnnIFAIVAaILMGLSK--IAKSFEMIIVGRFLVGINAGISLNVVPMY 130
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 177 IAETAEPNLRSLLIGAPYVAYSSGILMV------YSLGSMMYWrSVAWCANVLP-LLSMVSISFIPETPAWLL-RNGHEK 248
Cdd:cd17432 131 LGESAPKNLRGAVGLVPAIFITLGILLGqvlglrELLGNEEGW-PLLLALTGVPaLLQLLTLPFFPESPRYLLiEKGDEE 209
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 249 RALQALSFLRGSEiSAQKELNDMKQRLAKERvtTKTNENIFQLCCQRVAIKPLVIVIVFSLLQMFSGTFIVIFYAVDMIS 328
Cdd:cd17432 210 AARKALQRLRGKE-DVDDEMEEMLEEQRAEK--GVGTVSVLELFRDRSVRWQLISIIVLMAGQQLCGINAIYFYADSIFL 286
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 329 EFGAEFDSKQ-AAIATAVVRVICCMVFCVVLIFVRRRRIMIVSGIGSGLFCLVLSVYQYARFDQPKMSYdvfVGAGCLLG 407
Cdd:cd17432 287 EAGIPEDKIQyVTVGTGACEVLATITCVLVIERLGRRPLLIGGFGLMAVWCAVLTVALSLQNTVSWMPY---LSIVCIFA 363
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 408 YII-FNTALMVMPGIMIGELFPARIRgRTAGGVFASMN-VALFIFAKKFPALQAMLKMRgVFLVFGVSSFLLTAFMCLFQ 485
Cdd:cd17432 364 YIAsFGIGPAGVPFILTTEIFDQSSR-PAAFMVAGSLNwLSNFLVGLLFPFIQEGLGAY-CFLVFAVICLLTAIYIFFVL 441
                       410
                ....*....|.
gi 45445390 486 PETKGRSLEHI 496
Cdd:cd17432 442 PETKGKTFLEI 452
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
103-487 1.92e-33

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 130.77  E-value: 1.92e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 103 WIASVHSLATPFGSLLSGPLADYLGRRRTLILSVIPLLLGWSTLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETAE 182
Cdd:cd17359  40 LVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAP 119
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 183 PNLRSLLIGAPYVAYSSGILMVY------------SLGSMMYWRSVAWCANVLPLLSMVSISFIPETPAWLLRNGHekra 250
Cdd:cd17359 120 AEIRGRLVSLNQLMIVFGQLLAYivnylianaggaDWLGAEGWRWMLGLEAIPAILFLLGMLFIPESPRWLVSKGK---- 195
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 251 lqalsflrgseisaqkelndmkqrlakervttktnenifqlccqrvaiKPLVIVIVFSLLQMFSGTFIVIFYAVDMISEF 330
Cdd:cd17359 196 ------------------------------------------------PILIIGIGLAIFQQFVGINVIFYYGPEIFQNA 227
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 331 GaeFDSKQAAIATAVVRVICcMVFCVVLIF----VRRRRIMIVSGIGSGLFCLVLSVYQYARFDQPKMSYDVFVgagCLL 406
Cdd:cd17359 228 G--FSENAALLQTIGIGVVN-VIFTIIAILlvdkVGRKPLLLIGSIGMAISLLLIGTAFYFAPGSQASGIVALV---LIL 301
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 407 GYII-FNTALMVMPGIMIGELFPARIRGRTAG-GVFAsMNVALFIFAKKFPALQAMLKMRGVFLVFGVSSFLLTAFMCLF 484
Cdd:cd17359 302 LFVAfFAMSWGPVTWVLLSEIFPNRIRGLAMGiAVFF-LWIANFLVSLTFPILLAAFGLAFTFLIFAVICVLAFLFVWKF 380

                ...
gi 45445390 485 QPE 487
Cdd:cd17359 381 VPE 383
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
114-496 6.41e-32

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 126.70  E-value: 6.41e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 114 FGSLLSGPLADYLGRRRTLILSVIPLLLGWSTLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETAEPNLRSLLIGAP 193
Cdd:cd17362  54 LGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLK 133
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 194 YVAYSSGILMVYSLGSMMY-----WRSVAWCANVLPLLSMVSISFIPETPAWllrnghekralqalsflrgseisaqkel 268
Cdd:cd17362 134 ELFIVLGILLGYVSGYAFAdvvggWRYMYGLAAPPALLLGIGMWFLPPSPRW---------------------------- 185
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 269 ndmkqrlakervttktnenifqlccQRVAIKPLVIVIVFSLLQMFSGTFIVIFYAVDMISE--FGAEFDSKQAAIATAVV 346
Cdd:cd17362 186 -------------------------QGNYRKPLIIGLGLVLFQQITGQPSVLYYAATIFKSagFSAASDATLVSVGLGVF 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 347 RVICCMVFCVVLIFVRRRRIMI--VSGIGSGLFCLVLsvyqYARFDQPKMSYDVFVGAGCLLGYI-IFNTALMVMPGIMI 423
Cdd:cd17362 241 KLLMTIVAVLLVDKLGRRPLLLggVSGMVVSLFLLAA----YNLFVQMGPAGLAWLSLVALLLYVgAYQISFGPISWLMV 316
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 45445390 424 GELFPARIRGRtAGGVFASMNVAL-FIFAKKFPALQAMLKMRGVFLVFGVSSFLLTAFMCLFQPETKGRSLEHI 496
Cdd:cd17362 317 SEIFPLRVRGR-AIALAVLVNFGSnALVSLAFLPLQELIGLPGTFLGFGVIGVLALLFIYFTVPETKGLSLEEI 389
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
84-487 2.00e-30

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 121.91  E-value: 2.00e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  84 PQLMDNNSTEIPIDVETGSWIASVHSLATPFGSLLSGPLADYLGRRRTLILSVIPLLLGWSTLAIAKSIKVVIFARFLCG 163
Cdd:cd17315  19 ALLYIAKDLGFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLG 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 164 FATGILGGPGQVYIAETAEPNLRSLLIGAPYVAYSSGILMVYSLGSMM-YWRSVAWcanvlplLSMVSISFIpetPAWLL 242
Cdd:cd17315  99 LGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALsLSPPGWW-------RLMFALAAV---PALLQ 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 243 rnghekraLQALSFLRGSeisaqkelndmkqrlakervttktnenifqlccqrvaiKPLVIVIVFSLLQMFSGTFIVIFY 322
Cdd:cd17315 169 --------LLLMFFLPES--------------------------------------RALLVGVGLQLLQQLTGINAVMYY 202
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 323 AVDMISEFGAEFDSKQAAIATAVVRVICCMVFCVVLIFVRRRRIMIVSGIGSGLFCLVLSVYQYARFDQPKMSYdvfVGA 402
Cdd:cd17315 203 APTIFKSAGGGTASILASIIVGVVNLLATLVAIRLVDKVGRRPLLLIGFAGMAASLLLLAIAFLLPALAKAAGW---LAL 279
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 403 GCLLGYII-FNTALMVMPGIMIGELFPARIRGRTAGGVFASMNVALFIFAKKFPALQAMLKMRGVFLVFGVSSFLLTAFM 481
Cdd:cd17315 280 LGILLYIAaFAMGAGPVPWLLLSEIFPLRIRGKGMAIATLVNWIFNFIVGLTFLIMVSTIGLAGVFIFFAAVCLLALVFV 359

                ....*.
gi 45445390 482 CLFQPE 487
Cdd:cd17315 360 FFFVPE 365
xylE PRK10077
D-xylose transporter XylE; Provisional
115-501 9.48e-28

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 116.33  E-value: 9.48e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  115 GSLLSGPLADYLGRRRTLILSVIPLLLG-----WSTLAIAKS--------IKVVIFaRFLCGFATGILGGPGQVYIAETA 181
Cdd:PRK10077  71 GGALGGYCSNRFGRRDSLKIAAVLFFISalgsaWPEFGFTSIgpdntgyvPEFVIY-RIIGGIGVGLASMLSPMYIAEIA 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  182 EPNLRSLLIGAPYVAYSSGILMVYSL-------GSMMYWRSVAW----CANVLP-LLSMVSISFIPETPAWLLRNGHEKR 249
Cdd:PRK10077 150 PAHIRGKLVSFNQFAIIFGQLVVYFVnyfiarsGDASWLNTDGWrymfASEAIPaLLFLMLLYFVPETPRYLMSRGKQEQ 229
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  250 ALQALSFLRGSEiSAQKELNDMKQRLAKERVTTktnENIFQLccqrvAIKPLVIVIVFSLLQMFSGTFIVIFYAVDMISE 329
Cdd:PRK10077 230 AEGILRKIMGNT-LATQALQEIKHSLDHGRKTG---GKLLMF-----GVGVIVIGVMLSVFQQFVGINVVLYYAPEIFKT 300
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  330 FGAEFDSkqAAIATAVVRVICcMVFCVVLIFV----RRRRIMIVSGIGSGLFCLVLSVYQYARFdqpkmsydvfVGAGCL 405
Cdd:PRK10077 301 LGASTDI--ALLQTIIVGVIN-LTFTVLAIMTvdkfGRKPLQIIGALGMAIGMFSLGTAFYTQA----------PGIVAL 367
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  406 LGYIIFNTALMVMPG----IMIGELFPARIRGRTAGGVFASMNVALFIFAKKFPALQAMLKMRGVF------LVFGVSSF 475
Cdd:PRK10077 368 LSMLFYVAAFAMSWGpvcwVLLSEIFPNAIRGKALAIAVAAQWIANYFVSWTFPMMDKNSWLVAHFhngfsyWIYGCMGV 447
                        410       420
                 ....*....|....*....|....*.
gi 45445390  476 LLTAFMCLFQPETKGRSLEHIEDYFN 501
Cdd:PRK10077 448 LAALFMWKFVPETKGKTLEEMEALWE 473
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
88-500 3.28e-26

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 110.42  E-value: 3.28e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  88 DNNSTEIPIDVETGSwIASVHSLATPFGSLLSGPLADYLGRRRTLILSVIPLLLGWS-TLAIAKSIKVVIFARFLCGFAT 166
Cdd:cd17356  35 DNTGTYYPSSSRQGL-IVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIiQVAAIGKWYQLIVGRIIAGLGV 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 167 GILGGPGQVYIAETAEPNLRSLLIGAPYVAYSSGILMVY-------SLGSMMYWRsVAWCANVLP-LLSMVSISFIPETP 238
Cdd:cd17356 114 GFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGILVAYcinygthKLDGSAQWR-IPLGLQIVWgLLLLIGMFFLPESP 192
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 239 AWLLRnghekralqalsflrgseisaqkelndmkqrlakervttktnenifqlccqrvaikpLVIVIVFSLLQMFSGTFI 318
Cdd:cd17356 193 RWLYR---------------------------------------------------------TILGIMLQLFQQLTGINY 215
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 319 VIFYAVDMISEFGAEFDSK-QAAIATAVVRVICCMVFCVVLIFVRRRRIMIVSGIG-SGLFCLVLSVYQYARFDQPKMSY 396
Cdd:cd17356 216 FFYYGTTIFQSTGLTGSSPlLTSIILYIVNFVSTIPGLFFVDKFGRRTCLLIGAAGmSICLFIYAAVGVRYLIPNPQSGT 295
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 397 DVFVGAGCLLGYI-----IFNTALMVMPGIMIGELFPARIRGRTAGGVFASMNVALFIFAKKFPALQAMLKMrGVFLVFG 471
Cdd:cd17356 296 SNKSAGNGMIVFIclfifSFATTWGPIAWVYVAEVFPLRVRSKGMALATAFNWLWNFLISFFTPFIIGSIGF-KYYYIFA 374
                       410       420
                ....*....|....*....|....*....
gi 45445390 472 VSSFLLTAFMCLFQPETKGRSLEHIEDYF 500
Cdd:cd17356 375 GCNLLAFIVVFFFVPETKGLTLEEIDELF 403
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
106-491 3.87e-25

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 108.19  E-value: 3.87e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 106 SVHSLATPFGSLLSGPLADYLGRRRTL----ILSVI-PLLLGWSTLAiaKSIKVVIFARFLCGFATGILGGPGQVYIAET 180
Cdd:cd17431  57 AIFSVGGMIGSFSVGLFVNRFGRRNSMlynnLLAFAgAALMGLSKLA--KSYEMLILGRFIIGLYCGLTTGLVPMYIGEI 134
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 181 AEPNLRSLLIGAPYVAYSSGILM--VYSLGSMM----YWRSVAWCANVLPLLSMVSISFIPETPAWLLRN-GHEKRALQA 253
Cdd:cd17431 135 SPTALRGALGTLHQLGIVVGILIsqIFGLEFILgteeLWPLLLGFTIVPAILQLALLPFCPESPRYLLINrNEEEEAKSV 214
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 254 LSFLRGSEiSAQKELNDMKQRlaKERVTTKTNENIFQLCCQRVAIKPLVIVIVFSLLQMFSGTFIVIFYAVDMISEFGAE 333
Cdd:cd17431 215 LKKLRGTT-DVSEDIQEMKEE--SRQMMREKKVTILELFRSSSYRQPIIIAIVLQLSQQLSGINAVFYYSTSIFEKAGVQ 291
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 334 fDSKQAAIATAVVRVIccmvFCVVLIF-VRR--RRIMIVSGIGSGLFCLVLSVYQYARFDQ-PKMSYdvfVGAGCLLGYI 409
Cdd:cd17431 292 -QPVYATIGAGVVNTI----FTVVSLFlVERagRRTLHLIGLGGMAICAILMTIALLLLEGyPWMSY---VSIVAIFGFV 363
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 410 I-FNTALMVMPGIMIGELFPARIRGRtAGGVFASMN-VALFIFAKKFPALqAMLKMRGVFLVFGVSSFLLTAFMCLFQPE 487
Cdd:cd17431 364 AfFEIGPGPIPWFIVAELFSQGPRPA-AMAVAGFSNwTSNFIVGMCFQYI-ANLCGPYVFIIFTVFLLTFFIFTYFKVPE 441

                ....
gi 45445390 488 TKGR 491
Cdd:cd17431 442 TKGK 445
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
57-446 1.98e-21

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 95.81  E-value: 1.98e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  57 HQILATCAVLLLSAGCGMPIGFSAILLPQLMDnnstEIPIDVETGSWIASVHSLATPFGSLLSGPLADYLGRRRTLILSV 136
Cdd:COG2814   7 RRWLALLALALGAFLSGLGIGIVLPALPLIAA----DLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 137 IPLLLGWSTLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETAEPNLRSLLIGAPYVAYSSGILMVYSLGSMMY---- 212
Cdd:COG2814  83 LLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAdlfg 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 213 WRSVAWCANVLPLLSMVSISF-IPETPAwllrnghekralqalsFLRGSEISAQKELndmkqrlakervttktnenifql 291
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRlLPESRP----------------AARARLRGSLREL----------------------- 203
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 292 ccqrVAIKPLVIVIVFSLLQMFSGTFIVIFYAVDMISEFGaeFDSKQAAIATAVVrVICCMVFCVVLIF----VRRRRIM 367
Cdd:COG2814 204 ----LRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLG--LSASAAGLLLALF-GLGGVLGALLAGRladrFGRRRLL 276
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 45445390 368 IVSGIGSGLFCLVLSVYQyarfdqpkmSYDVFVGAGCLLGyiIFNTALMVMPGIMIGELFPARIRGRTAGGVFASMNVA 446
Cdd:COG2814 277 LIGLLLLALGLLLLALAG---------SLWLLLLALFLLG--FGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
104-487 1.58e-20

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 93.10  E-value: 1.58e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 104 IASVHSLATPFGSLLSGPLADYLGRRRTLILSVIPLLLGWSTLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETAEP 183
Cdd:cd17360  40 IVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPP 119
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 184 NLRSLLI--------GAPYVAYSSGILMVYSLGSmmyWRSVAWCANVLPLLSMVSISFIPETPAWllrnGHEKRALQALS 255
Cdd:cd17360 120 RIRGRLVtinvlfitGGQFVAYVINGAFSYLPGG---WRWMLGLAAVPAVLQFIGLLFLPESPRW----PSTRRALIVGC 192
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 256 FLRgseisaqkelndmkqrlakervttktnenifqlccqrvaikplvivivfsLLQMFSGTFIVIFYAVDMISEFGaeFD 335
Cdd:cd17360 193 GLQ--------------------------------------------------AFQQFSGINTVMYYSATILQMAG--FK 220
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 336 SKQAAIATAVVRVICCMVFCVVLIF----VRRRRIMIVSGIGSGLFCLVLSVYqyarfdqpkmsydvFVGAGCLLGYIIF 411
Cdd:cd17360 221 DNQNAIWLSLIVAGTNFIFTIVGMYlidkFGRRKLLLISLFGVIVALVVLAVW--------------LALVGLILYLAFF 286
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 45445390 412 NTALMVMPGIMIGELFPARIRGrTAGGVFASMN-VALFIFAKKFPALQAMLKMRGVFLVFGVSSFLLTAFMCLFQPE 487
Cdd:cd17360 287 APGMGPVPWTVNSEIYPLWARG-TGGGCAAAVNwVFNLLVSQTFLTLTQAIGPYGTFLLFAGLAVLGLIFIYFCVPE 362
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
43-441 1.75e-20

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 93.58  E-value: 1.75e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390    43 DEQDDDAANRRGMMHQILATCAVLLlsagCGMPIGFSAILLPQLmdnnSTEIPIDVETGSWIASVHSLATPFGSLLSGPL 122
Cdd:TIGR00895   4 NNIRKQPLSRYQWRAIILSFLIMLM----DGYDLAAMGFAAPAI----SAEWGLDPVQLGFLFSAGLIGMAFGALFFGPL 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390   123 ADYLGRRRTLILSVIPLLLGWSTLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETAEPNLRSLLIGAPYVAYSSGIL 202
Cdd:TIGR00895  76 ADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAA 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390   203 MVYSLGSMMY----WRSVAWCANVLPLLSM-VSISFIPETPAWLLRNGHEKRALQALSFLRGSEISAQKELNDMKQRLAK 277
Cdd:TIGR00895 156 VGGFLAGWLIpvfgWRSLFYVGGIAPLLLLlLLMRFLPESIDFLVSKRPETVRRIVNAIAPQMQAEAQSALPEQKSTQGT 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390   278 ERVTTKTnenIFQlcCQRVAIKPLVIVIVFSLLQMFsgtFIVIFYAVDMISEFGaeFDSKQAAIATAVVR---VICCMVF 354
Cdd:TIGR00895 236 KRSVFKA---LFQ--GKTARITVLLWLLYFMLLVGV---YFLTNWLPKLMVELG--FSLSLAATGGALFNfggVIGSIIF 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390   355 CVVLIFVRRRRIMIVSGIGSglfclVLSVYQYARFDQPkmsyDVFVGAGCLLGyIIFNTALMVMPGIMiGELFPARIRGR 434
Cdd:TIGR00895 306 GWLADRLGPRVTALLLLLGA-----VFAVLVGSTLFSP----TLLLLLGAIAG-FFVNGGQSGLYALM-ALFYPTAIRAT 374

                  ....*..
gi 45445390   435 TAGGVFA 441
Cdd:TIGR00895 375 GVGWAIG 381
MFS_PLT cd17437
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...
92-496 1.48e-17

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340995 [Multi-domain]  Cd Length: 387  Bit Score: 84.76  E-value: 1.48e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  92 TEIPIDVETGSWiasvhSLATPFGSLLSGPLADYLGRRRTLILSVIPLLLGWSTLAIAKSIKVVIFARFLCGFATGILGG 171
Cdd:cd17437  30 SDVQEEVLIGSL-----NIISLVGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYPVLMVGRFVAGIGVGFALM 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 172 PGQVYIAETAEPNLRSLLIGAPYVAYSSGILMVY-------SLGSMMYWRSVAWCANVLPLLSMVSISFIPETPAWllrn 244
Cdd:cd17437 105 IAPVYTAEVAPASSRGFLTSFPEIFINIGILLGYvsnyafsGLPLHVGWRLMLGVGAVPSLFLAIGVLAMPESPRW---- 180
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 245 ghekralqalsflrgseisaqkelndmkqrlakervttktnenifqlccqRVAIKPLVIVIV-FSLLQMFSGTFIVIFYA 323
Cdd:cd17437 181 --------------------------------------------------TPAVRRMLIAALgIHFFQQASGIDAVVLYS 210
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 324 VDMISEFGAEFDSKQ--AAIATAVVRVICCMVFCVVLIFVRRRRIMIVSGIGS--GLFCLVLSVYQYARFDQpKMSYDVF 399
Cdd:cd17437 211 PRIFKKAGIKSKDKLllATVAVGVTKTLFILVATFLLDKVGRRPLLLTSTGGMtlSLTALATSLTFIDRNGG-GLTWALV 289
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 400 VGAGCLLGYI-IFNTALMVMPGIMIGELFPARIRGRTAGGVFASMNVALFIFAKKFPALQAMLKMRGVFLVFGVSSFLLT 478
Cdd:cd17437 290 LAITAVCSFVaFFSIGAGPITWVYSSEIFPLRLRAQGASLGVVVNRLMSGTVSMTFLSMSKAITTGGTFFLFAGVAAAAW 369
                       410
                ....*....|....*...
gi 45445390 479 AFMCLFQPETKGRSLEHI 496
Cdd:cd17437 370 VFFYFFLPETKGKSLEEI 387
MFS_GLUT12_Class3 cd17435
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
114-496 3.26e-17

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340993 [Multi-domain]  Cd Length: 376  Bit Score: 83.31  E-value: 3.26e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 114 FGSLLSGPLADYLGRRRTLILSVIPLLLGWSTLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETAEPNLRSLLIGAP 193
Cdd:cd17435  51 LASLTGGVLIDRYGRRTAIILTSCLLVLGSLLLVCSVSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLN 130
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 194 YVAYSSGILMVYSLGSMMY-----WRSVAWCANVLPLLSMVSISFIPETPAWLLRNghekralqalsflrgseisaqkel 268
Cdd:cd17435 131 ELMIVIGILLAYISNYAFAnvsngWKYMFGLVIPLAALQAIAMYFLPPSPRFLVMK------------------------ 186
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 269 NDMKQRLakervttktnenifqlccqrvaikplVIVIVFSLLQMFSGTFIVIFYAVDMISEFGaeFDSKQAA----IATA 344
Cdd:cd17435 187 DNMRARL--------------------------LIGLTLVFFVQITGQPNILFYASTVLKSVG--FQSNEAAslasTGVG 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 345 VVRVICCMvfcvvlifvrrRRIMIVSGIGSGLFCLVLSVYQYARFdqpkMSYDVFVGAGCLLGYII-FNTALMVMPGIMI 423
Cdd:cd17435 239 VVKVVSTI-----------PAIFLVDKVGSKTFLCIGSSVMAVSL----VTMGLWLSLASLLVYVAaFSIGLGPMPWLVL 303
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 45445390 424 GELFPARIRGRtAGGVFASMNVAL-FIFAKKFPALQAMLKMRGVFLVFGVSSFLLTAFMCLFQPETKGRSLEHI 496
Cdd:cd17435 304 SEIFPGGIRGR-AMALTSSMNWGInLLISLTFLTVTELIGLPWVCFIYTAMSLASLVFVIMFVPETKGCSLEQI 376
MFS_1 pfam07690
Major Facilitator Superfamily;
65-451 9.21e-17

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 81.70  E-value: 9.21e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390    65 VLLLSAGCGMPIGFSAILLPQLMdnnSTEIPIDVETGSWIASVHSLATPFGSLLSGPLADYLGRRRTLILSVIPLLLGWS 144
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLL---AEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390   145 TLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETAEPNLRSLLIGAPYVAYSSGILMVYSLGSMMY----WRSVAWCA 220
Cdd:pfam07690  78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAslfgWRAAFLIL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390   221 NVLPLLSMVsisfipetPAWLLRNGHEKRALQALSFLRGSEISAQKELndmkqrlakervttktnenifqlccqrvaIKP 300
Cdd:pfam07690 158 AILSLLAAV--------LLLLPRPPPESKRPKPAEEARLSLIVAWKAL-----------------------------LRD 200
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390   301 LVIVIVFSLLQMFSGTFIVIFYAVDMISEFGaeFDSKQAAIATAVVRVICCMVFCVVLIFVRR---RRIMIVSGIGSGLF 377
Cdd:pfam07690 201 PVLWLLLALLLFGFAFFGLLTYLPLYQEVLG--LSALLAGLLLGLGGLLGAIGRLLLGRLSDRlgrRRRLLLALLLLILA 278
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 45445390   378 CLVLSVYQYArfDQPKMSYDVFVGAGclLGYIIFNTALMVmpgiMIGELFPARIRGRTAGGVFASMNVALFIFA 451
Cdd:pfam07690 279 ALGLLLLSLT--LSSLWLLLALLLLG--FGFGLVFPALNA----LVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
65-480 1.07e-16

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 81.70  E-value: 1.07e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  65 VLLLSAGCGMPIGFSAILLPQLMdnnsTEIPIDVETGSWIASVHSLATPFGSLLSGPLADYLGRRRTLILSVIPLLLGWS 144
Cdd:cd06174   1 LLLGFFLTGLARGLISPLLPALL----QSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGAL 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 145 TLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETAEPNLRSLLIGAPYVAYSSGILMVYSLGSMMY------WRSVAW 218
Cdd:cd06174  77 LFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAsslgfgWRAVFL 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 219 CANVLPLLSMVSISFIPETPAWllrnghekralqalsflrgseisaqkelndmKQRLAKERVTTKTNENIFQLccqRVAI 298
Cdd:cd06174 157 IAAALALLAAILLLLVVPDPPE-------------------------------SARAKNEEASSKSVLKLLKR---VLKN 202
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 299 KPLVIVIVFSLLQMFSGTFIVIFYAVDMISEFGAEFDSKQAAIATAVVRVICCMVFCVVLI--FVRRRRIMIVSGIGSGL 376
Cdd:cd06174 203 PGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSdrLIGRKPLLLIGLLLMAL 282
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 377 FCLVLSvyqyarfdqpkMSYDVFVGAGCLLGYIIFNTALMVMPGIMIGELFPARIRGrTAGGVFASMNVALFIFAkkfPA 456
Cdd:cd06174 283 GLALLL-----------LAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRG-TAFGLLNTFGFLGGAIG---PL 347
                       410       420
                ....*....|....*....|....*....
gi 45445390 457 LQAMLKM-----RGVFLVFGVSSFLLTAF 480
Cdd:cd06174 348 LAGFLLAatfglTGAFLVLAVLLLLAAIL 376
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
49-243 6.37e-16

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 78.31  E-value: 6.37e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  49 AANRRGMMHQILATCAVLLLSAGCGMPIGFSAILLPQLmdnnSTEIPIDVETGSWIASVHSLATPFGSLLSGPLADYLGR 128
Cdd:COG0477   3 STDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSI----AADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGR 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 129 RRTLILSVIPLLLGWSTLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETAEPNLRSLLIGAPYVAYSSGILMVYSLG 208
Cdd:COG0477  79 KRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLG 158
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 45445390 209 SMMY----WRSVAWCANVLPLLSMVSISFIPETPAWLLR 243
Cdd:COG0477 159 GLLVaalgWRWIFLINAPLGLLALVLRLRLPESRGLLLA 197
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
53-492 2.61e-14

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 74.53  E-value: 2.61e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  53 RGMMHQILATCAVLLLSAGCGMPIGFSAILLPQLMDNNSTEIpidvetgSWIASVHSLATPFGSLLSGPLADYLGRRRTL 132
Cdd:COG2223   1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQL-------GLLFAIPVLVGALLRIPLGFLVDRFGPRRVL 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 133 ILSVIPLLLGWSTLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETAEPNLRSLLIGAPYVAYSSGILMVYSLGSMMY 212
Cdd:COG2223  74 LIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLI 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 213 ----WRSVAWCANVLPLLSMVSIS-FIPETPAwllrnghekralqalsflrGSEISAQKELNDMKQrLAKERVTtktnen 287
Cdd:COG2223 154 aafgWRNAFLILGILLLVVAVLAWlFLRDPPA-------------------GAAAAAKASLRDQLE-ALRDPRF------ 207
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 288 ifqlccqrvaikpLVIVIVFSLlqMFSGTFIVIFYAVDMISEFgAEFDSKQAAIATAVVrVICCMVFCVVLIF----VRR 363
Cdd:COG2223 208 -------------WLLSLLYFG--TFGSFIGFSSWLPPYLVDQ-FGLSAATAGLLAALF-ALLGALGRPLGGWlsdrIGG 270
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 364 RRIMIVSGIGSGLFCLVLSVYQyarfdqpkMSYDVFVGAGCLLG--YIIFNTALMvmpgIMIGELFPARIRGRTAGGVFA 441
Cdd:COG2223 271 RRVLLIVFALMALGLLLLALAL--------GSLWLFLVLFLLLGlaLGGGNGAVF----ALVPDIFPTKNAGAVYGLVGA 338
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|..
gi 45445390 442 SMNVALFIFAKKFPALQAMLK-MRGVFLVFGVSSFLLTAFMCLFQPETKGRS 492
Cdd:COG2223 339 AGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLYRRPRRAA 390
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
76-484 2.72e-14

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 74.18  E-value: 2.72e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  76 IGFSAILLPQLMDNNSTEIpidveTGSWIASVHSLATPFGSLLSGPLADYLGRRRTLILSVipLLLGWSTLAIA--KSIK 153
Cdd:cd17316  18 IGFVAPVLAAEFSLGLSLL-----QTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTL--LLFGLATLLIGllPTPI 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 154 VVIFARFLCGFATGILGGPGQVYIAETAEPNLRSLLIGAPYVAYSSGILMVYSLGSMMYWRSVAWCANVLPLLSMVSISF 233
Cdd:cd17316  91 LLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGWRILFLIGALPAL 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 234 IpetpAWLLRnghekralqalsflrgseisaqkelndmkqrlakervttktnenifqlccqrvaiKPLVIVIVFSLLQMF 313
Cdd:cd17316 171 L----ALLLR-------------------------------------------------------RRTLLLILLWFFISF 191
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 314 SGTFIVIFYAVDMISEFGaeFDSKQAAIATAVVRV--ICCMVFCVVLI-FVRRRRIMIVSGIGSGLFCLVLSVYqyarfd 390
Cdd:cd17316 192 GYYGLTTFLPTYLQTVLG--LSPATSSLYLLLISLgaLVGALIAGLLSdRIGRKKTLVIGLILSGILALPLFYL------ 263
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 391 qpkMSYDVFVGAGCLLGYIIFNTALMVMPGIMIGELFPARIRGrTAGGVFASMNVALFIFAkkFPALQAMLKMRGVFLVF 470
Cdd:cd17316 264 ---LSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRA-TGVGLSYNLGRLGGGGA--PPLIALLLASTGGTGVP 337
                       410
                ....*....|....*.
gi 45445390 471 GVSSFLLT--AFMCLF 484
Cdd:cd17316 338 ALILALLAivALIVAL 353
MFS_GLUT10_Class3 cd17436
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
114-496 4.58e-14

Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340994 [Multi-domain]  Cd Length: 376  Bit Score: 73.68  E-value: 4.58e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 114 FGSLLSGPLADYLGRRRTLILSVIPLLLGWSTLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETAEPNLRSLLIGAP 193
Cdd:cd17436  51 LASLIGGFLIDRHGRRTSILGSNLVLLAGSLILTLAGSFFWLVIGRAVVGFAISVSSMACCIYVSEMVTPHQRGLLVSLY 130
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 194 YVAYSSGILMVYSL-----GSMMYWRSVAWCANVLPLLSMVSISFIPETPAWL-LRNGHEKRALQALSFLrgseisaqke 267
Cdd:cd17436 131 EAGITVGILISYALnyffsNVLTGWRYMFGLAIIPAAIQFASILLLPKKPEVLnIKDNMRRRTLVGLGLV---------- 200
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 268 lndmkqrlakervttktnenifqlccqrvaikplvivivfsLLQMFSGTFIVIFYAVDMISEFGAEFDSKQ--AAIATAV 345
Cdd:cd17436 201 -----------------------------------------LFQQFTGQPNVLCYASTIFRSVGFQSNSSAvlASVGLGV 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 346 VRVICCMVfcvVLIFVRR--RRIMIVSGigsglfCLVLSVYQYArfdqpkmsYDVFVGAGCLLGYI-IFNTALMVMPGIM 422
Cdd:cd17436 240 VKVIATLL---AMLFADRagRRSLLIAG------CSVMAVSVSG--------IGLWITLLCLMAFVsAFSIGFGPMTWLV 302
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 45445390 423 IGELFPARIRGRtAGGVFASMNVAL-FIFAKKFPALQAMLKMRGVFLVFGVSSFLLTAFMCLFQPETKGRSLEHI 496
Cdd:cd17436 303 LSEIYPADIRGR-AFSFCNSFNWAAnLLITLSFLDLIDVIGLSWTFLLYGVVGVAGVVFIYLFVPETKGQSLEEI 376
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
77-488 8.00e-14

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 73.11  E-value: 8.00e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  77 GFSAILLPQLMDNNSTEIPID-VETGSwIASVHSLATPFGSLLSGPLADYLGRRRTLILSVIPLLLGWSTLAIAKSIKVV 155
Cdd:cd17371  12 GFDLLLLGLVLPALIAEFGLDeAEAGL-LGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 156 IFARFLCGFATGILGGPGQVYIAETAEPNLRSLLIGAPYVAYSSGILMVYSLGSMMY--------WRSVAWCAnVLPLLS 227
Cdd:cd17371  91 LILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFpllppeiaWRVLFLLG-ALPALL 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 228 MVSI-SFIPETPAWLlrnghEKRALQALSFLRGSeisaqkelndmkQRLAKERVTTKTNenifqlccqrvaikpLVIVIV 306
Cdd:cd17371 170 VLFIrRFVKEPPQWQ-----AARAARRHFADRPS------------LRELFSPPLLRTT---------------LLASLL 217
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 307 FSLLQmFSGTFIVIFYAVDMISEFGAEFDSKQAAIATAVVRVIC---CMVFCVVLIfvRRRRIMIVSGIGSGLFclVLSV 383
Cdd:cd17371 218 ATGAL-GGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLgylAGGFLADRI--GRRNNFALFALGSAIS--ILLY 292
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 384 YQYARfdqpkmSYDVFVGAGCLLGYI---IFNTALMVMPgimigELFPARIRGrTAGGVFASMNVALFIFakkFPALQAM 460
Cdd:cd17371 293 FFLPL------SPTLILILGFPLGFFasgPFSGMGAYLT-----ELFPTAVRA-TAQGFCYNVGRIIGAL---FPFLVGF 357
                       410       420       430
                ....*....|....*....|....*....|..
gi 45445390 461 LKMRG----VFLVFGVSSFLLTAFMCLFQPET 488
Cdd:cd17371 358 LATSGslgtAIAVFAAVYYIAGLVLALLLPET 389
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
80-489 4.96e-13

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 70.67  E-value: 4.96e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  80 AILLPQLMDnnstEIPIDVETGSWIASVHSLATPFGSLLSGPLADYLGRRRTLILSVIPLLLGWSTLAIAKSIKVVIFAR 159
Cdd:COG2271  30 SVAAPPLQA----DLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLR 105
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 160 FLCGFATGILGGPGQVYIAETAEPNLRSLLIGAPYVAYSSGILMVYSLGSMMY----WRSVAWCANVLPLLsmvsisfip 235
Cdd:COG2271 106 FLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLaafgWRAAFLILGLPGLL--------- 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 236 etpawllrnghekralqalsflrgseisaqkelndmkqrlakervttktnenifqlccqrVAIKPLVIVIVFSLLQMFSG 315
Cdd:COG2271 177 ------------------------------------------------------------LALLRFWLLALAYFLVYFAL 196
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 316 TFIVIFYAVDMISEFGaeFDSKQAAIATAVVrVICCMVFCVVL------IFVRRRRIMIVSGIGSGLFCLVLSVYQyarf 389
Cdd:COG2271 197 YGFLTWLPTYLVEVRG--LSLAQAGLLLSLP-FLAGIVGSLLGgwlsdrLGRRRKLVLAIGLLLAALALLLLALLP---- 269
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 390 dqpkmsyDVFVGAGCLLGYIIFNTALMVMPGIMIGELFPARIRGRTAGGVFASMNVALFIFAKKFPALQAMLKMRGVFLV 469
Cdd:COG2271 270 -------SPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLL 342
                       410       420
                ....*....|....*....|
gi 45445390 470 FGVSSFLLTAFMCLFQPETK 489
Cdd:COG2271 343 LAALALLAALLALLLLRETR 362
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
102-235 4.33e-11

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 64.14  E-value: 4.33e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 102 SWIASVHSLATPFGSLLSGPLADYLGRRRTLILSVIPLLLGWSTLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETA 181
Cdd:cd17317  28 ALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIV 107
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 45445390 182 EPNLRSLLIGAPYVAYSSGILMVYSLGSMM-YWRSVAWCANVLPLLSMVSISFIP 235
Cdd:cd17317 108 GPKYRSFVGILFGLFWALGYMLLALLAYLIrDWRWLQLAISLPGLLFLLLLWWLP 162
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
110-489 7.79e-11

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 63.85  E-value: 7.79e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 110 LATPFGSLLSGPLADYLGRRRTLILSV---------IPLLLGWSTLAIAKSIkVVIFARFLCGFATGILGGPGQVYIAET 180
Cdd:cd17367  51 LMRPIGGWLFGRLADRIGRRAALTLSVslmaagslvIAVTPTYATIGIWAPI-ILLLARLLQGLSVGGEYGTSATYLSEV 129
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 181 AEPNLRSL--------LIGAPYVAYSSGILMVYSLG-SMMY---WRSVAWCANVLPLLSMvsisfipetpaWLLRNGHEK 248
Cdd:cd17367 130 APPGRRGFyssfqyvtLIGGQLLALGVLLVLQHTLGeDQMAawgWRIPFLLGGVLAVVVL-----------WLRRGLEET 198
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 249 RALQalsflrgseisAQKELNDMKQRLAKERVTTKtnenifqlccqrvaiKPLVIVIVFSLLqmfsGTfiVIFYAVD--- 325
Cdd:cd17367 199 ESFE-----------AIAESNEASAGTLRELRRHP---------------RELLLVVGLTAG----GT--LAFYTWTtyl 246
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 326 ---MISEFGaeFDSKQAAIATAVVRViccmVFCVVLIF-------VRRRRIMIVSGIGSGLFCLVLSVYqyarFDQPKMS 395
Cdd:cd17367 247 qkfLVNTAG--FSKGDATWITTAALL----VFMLLQPLggrlsdrIGRRPLLLFFGIGGTLATVPLLSA----LDHTDSP 316
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 396 YDVFVGAGCLLGYIIFNTALMvmpGIMIGELFPARIRgrtAGGVFASMNVALFIFAKKFPALQAMLK---MRGVFLVFGV 472
Cdd:cd17367 317 YTAFALVLVGLVFLSGYTSIN---AVVKAELFPTHVR---ALGVGLPYALAVAIFGGTAPYVALWLKsigHEWVFFWYVA 390
                       410
                ....*....|....*..
gi 45445390 473 SSFLLTAFMCLFQPETK 489
Cdd:cd17367 391 GLIAISLVVYLRMPETR 407
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
115-494 7.91e-11

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 64.27  E-value: 7.91e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390   115 GSLLSGPLADYLGRRRTLILS-VIPLLLGWSTlAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETAEPNLR---SLLI 190
Cdd:TIGR00898 143 GSFVFGYLSDRFGRKKVLLLStLVTAVSGVLT-AFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRaivGTLI 221
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390   191 GapyVAYSSGILMVYSLGSM-MYWRSVAWCANVLPLLSMVSISFIPETPAWLLRNGHEKRALQALsfLRGSEISAQKELN 269
Cdd:TIGR00898 222 Q---VFFSLGLVLLPLVAYFiPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKIL--QRIAKINGKKLPA 296
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390   270 DMKQ-RLAKERVTTKTNENIFQLCCQRVAIKPLVIVIvfslLQMFSGTFIVIFYAVDMiSEFGaeFDSKQAAIATAVVRV 348
Cdd:TIGR00898 297 EVLSlSLEKDLSSSKKQYSFLDLFRTPNLRKTTLCLM----MLWFTTAFSYYGLVLDL-GNLG--GNIYLDLFISGLVEL 369
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390   349 ICCMVFCVVLIFVRRRRIMIVSGIGSGLFCLVLsvyqyarFDQPKMSYD-----VFVGAGCLlgyiifnTALMVMPGIMI 423
Cdd:TIGR00898 370 PAKLITLLLIDRLGRRYTMAASLLLAGVALLLL-------LFVPVDLYFlrtalAVLGKFGI-------TSAFQMVYLYT 435
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 45445390   424 GELFPARIRgRTAGGVFASMNVALFIFAKKFpalqAMLKMRGVFL---VFGVSSfLLTAFMCLFQPETKGRSLE 494
Cdd:TIGR00898 436 AELYPTVVR-NLGVGVCSTMARVGSIISPFL----VYLGEKWLFLplvLFGGLA-LLAGILTLFLPETKGVPLP 503
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
102-481 1.77e-10

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 62.59  E-value: 1.77e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 102 SWIASVHSLATPFGSLLSGPLADYLGRRRTLILSVipLLLGWSTL--AIAKSIKVVIFARFLCGFATGILGGPGQVYIAE 179
Cdd:cd17325  34 GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGL--LLLAVSTLlfAFATSYWQLLLARFLQGLASAAVWPAAMALIAD 111
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 180 TAEPNLRSLLIGAPYVAYSSGILMVYSLGSMMY----WRSVAWCANVLPLLSMVSISFIPETPawllRNGHEKRALQALS 255
Cdd:cd17325 112 IAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLAdalgYRAPFLVCAALALLALVLALLLLPEP----RPPPNKRAVSAAR 187
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 256 FLRGSEISAQKelndmkqrlakervttktnenifqlccqrvaiKPLVIVIVFSLLQMFSGTFIVIFYAVDMISEFGaeFD 335
Cdd:cd17325 188 LRSGLRLLLRD--------------------------------RRLLALFLAIFVLAFAFGALEPFLPLYAAELGG--LS 233
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 336 SKQAAIATAVVRVIC--CMVFCVVLIFVRRRRIMIVSGIGSGLFCLVLsvyqYARFDQPKMSYDVFVGAGclLGYIIFNT 413
Cdd:cd17325 234 PAQIGLLFGAQGLASalSQPPAGKLSDRIGRKPLILIGLLLSAVALLL----LPLATSFWLLLLLLALLG--LGLGLVFP 307
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 45445390 414 ALMVmpgiMIGELFPARIRGRTAGGVFASMNVALFIFAKKFPALQAMLKMRGVFLVFGVSSFLLTAFM 481
Cdd:cd17325 308 ATLA----LLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLF 371
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
96-229 5.41e-10

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 61.06  E-value: 5.41e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  96 IDVETGSWIASVHSLATPFGSLLSGPLADYLGRRRTLILSVIPLLLGWSTLAIAKSIKVVIFARFLCGFATGILGGPGQV 175
Cdd:cd17365  31 LSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAIT 110
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 45445390 176 YIAETAEPNLRSLLIGAPYVAYSSGILMVYSLGSMMY----WRSVAWCANVLPLLSMV 229
Cdd:cd17365 111 LVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIpafgWRSVFLLGGVPPLILLP 168
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
65-234 9.67e-10

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 60.26  E-value: 9.67e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  65 VLLLSAGCG-------MPIGfsaiLLPQLmdnnSTEIPIDVETGSWIASVHSLATPFGSLLSGPLADYLGRRRTLILSVI 137
Cdd:cd17324   1 LLALALAAFaigtteyVIQG----LLPDI----ARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLL 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 138 PLLLGWSTLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETAEPNLRSLLIGAPYVAYSSGILMVYSLGSMMY----W 213
Cdd:cd17324  73 LFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGqllgW 152
                       170       180
                ....*....|....*....|.
gi 45445390 214 RSVAWCANVLPLLSMVSISFI 234
Cdd:cd17324 153 RAAFLAIAVLALLAALLLWRL 173
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
64-201 2.05e-09

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 59.22  E-value: 2.05e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  64 AVLLLSAGCGMPIGFSAILLPQLMDNNSTeipIDVETGSWIASVHSLATPFGSLLSGPLADYLGRRRTLILSVIPLLLGW 143
Cdd:COG2814 211 LLLLLAFLLGFGFFALFTYLPLYLQEVLG---LSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGL 287
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 45445390 144 STLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETAEPNLRSLLIGAPYVAYSSGI 201
Cdd:COG2814 288 LLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
2_A_01_02 TIGR00880
Multidrug resistance protein;
110-237 1.48e-08

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 53.42  E-value: 1.48e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390   110 LATPFGSLLSGPLADYLGRRRTLILSVIPLLLGWSTLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETAEPNLRSLL 189
Cdd:TIGR00880   9 LGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVA 88
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 45445390   190 IGAPYVAYSSGILMVYSLGSMMY----WRSVAWCANVLPLLSMVSISFI-PET 237
Cdd:TIGR00880  89 LGLMSAGIALGPLLGPPLGGVLAqflgWRAPFLFLAILALAAFILLAFLlPET 141
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
93-258 3.88e-08

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 55.74  E-value: 3.88e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390   93 EIPIDVETGSWIASVHSLATPFGSLLSGPLADYLGRRRTLILSVipLLLGWSTL--AIAKSIKVVIFARFLcgfaTGI-L 169
Cdd:PRK11551  44 EFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSV--ALFGLFSLatAQAWDFPSLLVARLL----TGVgL 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  170 GGPGQVYIA---ETAEPNLRSLLIGAPYV------AYSSGILMVYSLGSMmyWRSVAWCANVLPLLSM-VSISFIPETPA 239
Cdd:PRK11551 118 GGALPNLIAltsEAVGPRLRGTAVSLMYCgvpfggALASVIGVLAAGDAA--WRHIFYVGGVGPLLLVpLLMRWLPESRA 195
                        170
                 ....*....|....*....
gi 45445390  240 WLLRNGHEKralQALSFLR 258
Cdd:PRK11551 196 FAQAAGAGK---QRAPVLR 211
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
65-211 7.57e-08

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 54.53  E-value: 7.57e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  65 VLLLSAGCGMPIGFSAILLPQLMdnnSTEIPIDVETGSWIASVHSLATPFGSLLSGPLADYLGRRRTLILSVI--PLLLG 142
Cdd:cd17316 182 LILLWFFISFGYYGLTTFLPTYL---QTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLIlsGILAL 258
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 143 WSTLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETAEPNLRSLLIGAPY-VAYSSGILMVYSLGSMM 211
Cdd:cd17316 259 PLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYnLGRLGGGGAPPLIALLL 328
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
51-235 1.53e-07

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 53.70  E-value: 1.53e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  51 NRRGMMHQILATCAVLLLSagcGMPIGFSAILLPQLMDNNSteipIDVETGSWIASVHSLATPFGSLLSGPLADYLGRRR 130
Cdd:COG0738   2 SKKNYRRALIAIYLLFFLW---GFATALWGPLIPALKDAFG----LSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKR 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 131 TLILSVIPLLLGWSTLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAEtAEPNLRSLLIGAPYVAYSSGILMVYSLGSM 210
Cdd:COG0738  75 GLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAA-LGPETAASRLNLLHAFFSLGALLGPLLGGL 153
                       170       180       190
                ....*....|....*....|....*....|..
gi 45445390 211 M-------YWRSVAWCANVLPLLSMVSISFIP 235
Cdd:COG0738 154 LillglslSWHLPYLILAVLLLLLALLFLRSK 185
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
104-481 2.16e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 52.98  E-value: 2.16e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 104 IASVHSLATPFGSLLSGPLADYLGRRRTLILSVIPLLLGWSTLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETAEP 183
Cdd:cd17489  36 VVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPP 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 184 NLRSLLIGapYVAYSSGILMVY--SLGSMMY----WRSVAWCANVLPLLSMVSISFIPETPawllrnghekralqalsfl 257
Cdd:cd17489 116 SRRGEGIG--YYGLATTLAMALgpALGLFLYqhlgFAVLFIVAAVLALLALLLVFLVKDPP------------------- 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 258 rgseiSAQKELNDMKQRLAKERVttktnenifqlccQRVAIKPLVIVIVFSLLQMFSGTFIVIFYAVDMISEFGAEFDSk 337
Cdd:cd17489 175 -----PVAAEEAEAGTRAFRRLV-------------EKKVLPPALILFLASIAYGAISTFLPLYAAERGISNAGLFFTV- 235
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 338 qAAIATAVVRVICcmvfCVVLIFVRRRRIMIVSGIGSGLFCLVLSVYQYARfdqpkmsydVFVGAGCLLGyiIFNTALMV 417
Cdd:cd17489 236 -YAIALLLSRPFS----GKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPW---------MLLLAAVLYG--LGFGLLFP 299
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 45445390 418 MPGIMIGELFPARIRGRTAGGVFASMNVALFIFAKKFPALQAMLKMRGVFLVFGVSSFLLTAFM 481
Cdd:cd17489 300 ALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLY 363
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
65-485 5.19e-07

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 51.81  E-value: 5.19e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  65 VLLLSAGCgMPIGFSAILLPQLMDNNSTEIPIDVETGSWIASVHSLATPFGSLLSGPLADYLGRRRTLILSVIPLLLGWS 144
Cdd:cd17473   2 ITLLLAST-LTVMAGAAIAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 145 TLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETAEPNLRSLLIGAPYVAYSSGILMVYSLGSM---MYWR------S 215
Cdd:cd17473  81 AGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGAlaeIGWRapflvyL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 216 VAwcanvLPLLSMVSIsFIPETpawllrnghekralqalsflrgseisAQKELNDMKQRLAKERVTTktnenifqlccqr 295
Cdd:cd17473 161 LA-----LPVLILVLL-FLPEP--------------------------ARKSKSAASPGAATAAALP------------- 195
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 296 vaiKPLVIVIVFSLLQMFSGTFIVIFYAVDMISEFGAeFDSKQAAIATAVVRViccMVFCVVLIF---VRRRRIMIVSGI 372
Cdd:cd17473 196 ---WKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGG-GSAALIGLALAIASL---AGAIGALLFgrlKRRLGKRRLLAI 268
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 373 GSGLFCLVLSVYQYARFDQPKMSYDVFVGAGCllGYIIFNTALMVMpgimigELFPARIRGRTAGGVFASMNVALF---- 448
Cdd:cd17473 269 GFALMALGFLLLALASGLWVVLLGAILAGLGF--GLLLPTLNSWAM------SLVPPELRGRAMGIVTSAFFLGQFlspl 340
                       410       420       430
                ....*....|....*....|....*....|....*..
gi 45445390 449 IFAkkfPALQAMLKMRGVFLVFGVSSFLLTAFMCLFQ 485
Cdd:cd17473 341 VLG---PLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
59-235 7.72e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 51.41  E-value: 7.72e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  59 ILATCAVLLLSAGCGMPIGFSAILLPQLMdnnSTEIPIDVETGSWIASVHSLATPFGSLLSGPLADYLGRRR--TLILSV 136
Cdd:COG2271 179 LLRFWLLALAYFLVYFALYGFLTWLPTYL---VEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGL 255
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 137 IPLLLGWSTLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETAEPNLRSLLIGAPY-VAYSSGILMVYSLGSMM---Y 212
Cdd:COG2271 256 LLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNtFGFLGGALGPLLVGYLLdatG 335
                       170       180
                ....*....|....*....|...
gi 45445390 213 WRSVAWCANVLPLLSMVSISFIP 235
Cdd:COG2271 336 YQAAFLLLAALALLAALLALLLL 358
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
299-489 9.15e-07

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 51.13  E-value: 9.15e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 299 KPLVIVIVFSLLQMFSGTFIVIFYAVDMISEFGAEFDSKQAAIATAVVRVICCMVFCVVLI-FVRRRRIMIVSGIGSGLF 377
Cdd:COG2814   9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLAdRFGRRRVLLLGLLLFALG 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 378 CLVLSVYQyarfdqpkmSYDVFVGAGCLLGyiIFNTALMVMPGIMIGELFPARIRGRTAGGVFASMNVALFIFAKKFPAL 457
Cdd:COG2814  89 SLLCALAP---------SLWLLLAARFLQG--LGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLL 157
                       170       180       190
                ....*....|....*....|....*....|..
gi 45445390 458 QAMLKMRGVFLVFGVSSFLLTAFMCLFQPETK 489
Cdd:COG2814 158 ADLFGWRWVFLVNAVLALLALLLLLRLLPESR 189
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
63-239 1.00e-06

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 51.07  E-value: 1.00e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  63 CAVLLLSAGCGMPIGFSAILLPQLMDNNSTEIpidvetgSWIASVHSLATPFGSLLSGPLADYLGRRRTLILSVIPLLLG 142
Cdd:cd17329   6 IGSFLNRLGFFMVWPFMAIYLHQQLGLSASIV-------GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALG 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 143 WSTLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETAEPNLRSLLIGAPYVAYSSGILMVYSLGSMMY---WRSVAWC 219
Cdd:cd17329  79 FALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLlysFRLLFLA 158
                       170       180
                ....*....|....*....|.
gi 45445390 220 ANVLPLLSM-VSISFIPETPA 239
Cdd:cd17329 159 AAVLFLLAAlVLLFLLPETRP 179
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
102-191 1.23e-06

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 50.64  E-value: 1.23e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 102 SWIASVHSLATPFGSLLSGPLADYLGRRRTLILSVIPLLLGWSTLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETA 181
Cdd:cd17502  33 SWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLV 112
                        90
                ....*....|
gi 45445390 182 EPNLRSLLIG 191
Cdd:cd17502 113 PPRERGKYQG 122
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
57-234 1.69e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 50.27  E-value: 1.69e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  57 HQILATCAVLLLSAGC-GMPIGFSAILLPQLMDNNSTEIpidvetgSWIASVHSLATPFGSLLSGPLADYLGRRRTLILS 135
Cdd:cd17325 199 RRLLALFLAIFVLAFAfGALEPFLPLYAAELGGLSPAQI-------GLLFGAQGLASALSQPPAGKLSDRIGRKPLILIG 271
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 136 VIPLLLGWSTLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETAEPNLRSLLIGAPYVAYSSGILMVYSLGSMMY--- 212
Cdd:cd17325 272 LLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYdaf 351
                       170       180
                ....*....|....*....|...
gi 45445390 213 -WRSVAWCANVLPLLSMVSISFI 234
Cdd:cd17325 352 gFATPFLAAAALLLLAAVLFLLL 374
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
110-487 2.88e-06

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 49.56  E-value: 2.88e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 110 LATPFGSLLSGPLADYLGRRRTLILSVIPLLLGWSTLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETAEPNLRSLL 189
Cdd:cd17361  62 LAGLVASLLASYVTRKWGRKPSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYLSEMAPAKLRGAL 141
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 190 IGAPYVAYSSGILMV----YSLGSMMY--WRSVAWCANVLPLLSMVSISFIPETPAwllrnghekralqalsflrgseiS 263
Cdd:cd17361 142 NIGFQLAITIGILIAnlinYGTSKIKPngWRLSLGLAAVPALILLLGSLFLPETPN-----------------------S 198
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 264 AQkelndmkqrlakervttktnenifqlccqrvaikpLVIVIVFSLLQMFSGTFIVIFYAVDMISEFGaeFDSKQAAIAT 343
Cdd:cd17361 199 PQ-----------------------------------LVIAILIPFFQQLTGINVIMFYAPVLFQTLG--FGSDASLISA 241
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 344 AVVRVICCMVFCVVLIFVRR--RRIMIVSGIGSGLFCLVLS----VYQYARFDQPKMSYDVFVGAGCLLGYIIFNTALMV 417
Cdd:cd17361 242 VITGAVNVVSTLVSIYLVDRfgRRFLLLEGGVQMLASQVAIgillAVKFGDGGELPKAYAIAVVVLICLYVAAFAWSWGP 321
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 45445390 418 MPGIMIGELFPARIrgRTAGGVFASMNVALFIFAKKFPALQAMLKMR-GVFLVFGVSSFLLTAFMCLFQPE 487
Cdd:cd17361 322 LGWLVPSEIFPLET--RSAGQSLTVAVNFLFTFVIAQAFLSMLCAMKfGIFLFFAGWVVVMSLFVYFLLPE 390
MFS_1 pfam07690
Major Facilitator Superfamily;
304-507 3.02e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 49.34  E-value: 3.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390   304 VIVFSLLQMFSGTFIVIFYAVDMISEFGAEFDSKQAAIATAVVRVICCMVFCVVLI-FVRRRRIMIVSGIGSGLFCLVLS 382
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSdRFGRRRVLLIGLLLFALGLLLLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390   383 VYQyarfdqpkmSYDVFVGAGCLLGyiIFNTALMVMPGIMIGELFPARIRGRTAGGVFASMNVALFIFAKKFPALQAMLK 462
Cdd:pfam07690  81 FAS---------SLWLLLVLRVLQG--LGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG 149
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 45445390   463 MRGVFLVFGVSSFLLTAFMCLFQPETKGRSLEHIEDYFNGDNWLW 507
Cdd:pfam07690 150 WRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAW 194
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
45-229 3.43e-06

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 49.49  E-value: 3.43e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  45 QDDDAANRRGMMHQILATCAVLLLSAGCGMPIGFSAILLPQLMDnnstEIPIDVETGSWIASVHSLATPFGSLLSGPLAD 124
Cdd:COG2807   3 TTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRA----DLGLSATQAGLLTTLPLLAFGLFAPLAPRLAR 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 125 YLGRRRTLILSVIPLLLGWSTLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETAePNLRSLLIGapyvAYSSGILMV 204
Cdd:COG2807  79 RFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWF-PDRVGLMTG----LYTAAMGLG 153
                       170       180       190
                ....*....|....*....|....*....|...
gi 45445390 205 YSLGSMMY--------WRSVAWCANVLPLLSMV 229
Cdd:COG2807 154 AALAAGLTvplaaalgWRGALAVWALLALLALL 186
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
110-432 3.66e-06

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 49.45  E-value: 3.66e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 110 LATPFGSLLSGPLADYLGRRRTLILSVipLLLGWSTLAI-----AKSIKVV-----IFARFLCGFATGILGGPGQVYIAE 179
Cdd:cd17369  55 LARPLGGVVFGHFGDRIGRKKTLVLTL--LLMGIATFLIgllptYAQIGILapillVLLRLLQGLALGGEWGGAVLMAVE 132
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 180 TAEPNLRSLLIGAPYVAYSSGILM---VYSLGSMMY---------WRSVAWCANVLPLLSMVSISFIPETPAwllrnghe 247
Cdd:cd17369 133 HAPPKRRGFYGSFPQLGAPVGLLLatgVFLLLSALLsdeaflswgWRIPFLLSAVLVAVGLYIRLRLEETPV-------- 204
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 248 kralqalsFLRgseisaQKELNDMKQRLAKERVTTKtnenifqlccqrvaiKPLVIVIVFSLLQMFSGTFIVIFYAVdmi 327
Cdd:cd17369 205 --------FRR------AKEAGQVVRAPLVEVLRRH---------------WRALLLAIGLRLAENVLFYLFTTFAL--- 252
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 328 sEFGAEFDSKQAAIATAVVrVICCMVFCVVLIF-------VRRRRIMIVSGIGSGLFclvlsVYQYARFDQPKMSYDVFV 400
Cdd:cd17369 253 -SYATQTLGVDRSTVLLAV-LIASVVAAITIPLfgwlsdrVGRRPVYLAGALLAALF-----AFPFFWLLDTGSTWLIVL 325
                       330       340       350
                ....*....|....*....|....*....|..
gi 45445390 401 GAgcLLGYIIFNTALMVMPGIMIGELFPARIR 432
Cdd:cd17369 326 AA--VVVLGVLHGMMYGPQAAFLAELFPTRVR 355
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
102-191 4.63e-06

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 48.73  E-value: 4.63e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 102 SWIASVHSLATPFGSLLSGPLADYLGRRRTLILSVIPLLLGWSTLAIAKSIKVVIFARFLCGFATGILgGPGQVYIAETA 181
Cdd:cd17330  37 GLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNV-SVAQAYIADIT 115
                        90
                ....*....|
gi 45445390 182 EPNLRSLLIG 191
Cdd:cd17330 116 DEEERAKAFG 125
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
102-484 1.36e-05

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 47.61  E-value: 1.36e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 102 SWIASVHSLATPFGSLLSGPLADYLGRRRTLILS-----VIPLLLGWSTLAIAKSIKVVIFARFLCGFATGILGGPGQVY 176
Cdd:cd06173  37 GLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILAdllraLLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQAL 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 177 IAETAEPNLRSLLIGAPYVAYSSGILMVYSLGSMMY----WRSVAWCANVLPLLSMVSISFIPETPAwllRNGHEKRALQ 252
Cdd:cd06173 117 LPELVPKEQLVRANALNSLATQLARIIGPALGGLLVallgPGGAFAINALSFLLSALLLLFIRRPPP---AAPGESSSLL 193
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 253 ALSFLRGseisaqkelndmkqrlakervttktneniFQLCCQRVAIKPLVIVIVFSLLQMFSGTFIVIFYAVDMIsefga 332
Cdd:cd06173 194 LRDLREG-----------------------------LRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVL----- 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 333 EFDSKQAAIATAVVRV--ICCMVFC-VVLIFVRRRRIMIVSGIGSGLFCLVLSvyqyarfdqpkMSYDVFVGAGCLLGYI 409
Cdd:cd06173 240 GGGAAGYGLLLAAFGVgaLLGALLLgRLSKRRRRGRLLLIGALLLGLALLVLG-----------LSPSLWLLLAALFLLG 308
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 45445390 410 IFNTALMVMPGIMIGELFPARIRGRTAGGVFASMNVALFIFAKKFPALQAMLKMRGVFLVFGVSSFLLTAFMCLF 484
Cdd:cd06173 309 LAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
60-235 1.52e-05

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 47.18  E-value: 1.52e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  60 LATCAVLLLSAGCGMPIGFSAIllPQLMdnnsTEIPIDVETGSWIASVHSLATPFGSLLSGPLADYLGRRRTLILSVIPL 139
Cdd:cd17323   1 VFIISFLTFVVTFGSSIYSPAL--PQIA----EDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIF 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 140 LLGWSTLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETAEPNLRSLLIGapyvAYSSGILMVYSLGSMM-------- 211
Cdd:cd17323  75 VIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMG----VYSLGPLLGPALGPIIggfitqsl 150
                       170       180
                ....*....|....*....|....
gi 45445390 212 YWRSVAWCANVLPLLSMVSISFIP 235
Cdd:cd17323 151 GWRWIFWFLAIISGFCLILIFLFL 174
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
80-208 1.89e-05

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 46.80  E-value: 1.89e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  80 AILLPQLMdnnsTEIPIDVETGSWIASVHSLATPFGSLLSGPLADYLGRRRTLILSVIPLLLGWSTLAIAKSIKVVIFAR 159
Cdd:cd17503  16 NVALPTIM----GDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFR 91
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 45445390 160 FLCGFATGILGGPGQVYIAETAEPNLRSLLIGapyvAYSSGILMVYSLG 208
Cdd:cd17503  92 ILQGFGGGVLIPLAQTILLRIYPPEKRGAAMG----LVGLVILLAPAIG 136
MFS_CitA cd17368
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ...
113-249 2.47e-05

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340926 [Multi-domain]  Cd Length: 407  Bit Score: 46.60  E-value: 2.47e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 113 PFGSLLSGPLADYLGRRRTLILSVIPLLLGWSTLAIAKSIK--------VVIFARFLCGFATGILGGPGQVYIAETAEPN 184
Cdd:cd17368  54 PIGAIVLGAYADRIGRKPAMTLTLAIMALGTLLIALAPTYAtigiaaplLVLLARLLQGFAAGGEVGGVTAYLVEAAPPG 133
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 45445390 185 LR----SLLIGAPYVAYSSGILMVYSLGSMMYWRSVA-WCANVLPLLSMVSISFI-------PETPAWLLRNGHEKR 249
Cdd:cd17368 134 RRgfytSWQSASQQVAIVAGALVGYLLSLTLTAEALAeWGWRIPFFIGLLIIPLGlwlrrslEETEAFLERKARPTR 210
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
54-229 5.45e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 45.50  E-value: 5.45e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  54 GMMHQILATCAVLLLSAGCGMPIGFSAILLPQLMdnnSTEIPIDVETGSWIASVHSLATPFGSLLSGPLADYL-GRRRTL 132
Cdd:cd06174 197 KRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFL---LDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLiGRKPLL 273
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 133 ILSVIPLLLGWSTLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETAEPNLRSLLIGAPYVAYSSGILMVYSLGSMMY 212
Cdd:cd06174 274 LIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLL 353
                       170       180
                ....*....|....*....|..
gi 45445390 213 -----WRSVAWCANVLPLLSMV 229
Cdd:cd06174 354 aatfgLTGAFLVLAVLLLLAAI 375
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
97-200 6.45e-05

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 45.70  E-value: 6.45e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  97 DVETGSWIASVHSLATPFGSLLSGPLADYLGRRRTLILSVIPLLLGWSTLAIAKSIKVVIFARFLCGFATGILgGPGQVY 176
Cdd:cd06179  30 PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQ-GLGAAV 108
                        90       100
                ....*....|....*....|....
gi 45445390 177 IAETAEPNLRSLLIGAPYVAYSSG 200
Cdd:cd06179 109 ASELVPNKYRGLVQGVVNLVASPG 132
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
103-265 6.94e-05

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 45.74  E-value: 6.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390   103 WIASVHSLATPFGSLLSGPLADYLGRRRTLI--LSVIPLLLGWSTLaiAKSIKVVIFARFLCGFatGILGGPGQV--YIA 178
Cdd:TIGR01299 206 MLGLIVYLGMMVGAFFWGGLADKLGRKQCLLicLSVNGFFAFFSSF--VQGYGFFLFCRLLSGF--GIGGAIPIVfsYFA 281
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390   179 ETAEPNLRS---------LLIGAPYVAYSSGILM-----VYSLGS---MMYWRS-VAWCAnvLP-LLSMVSISFIPETPA 239
Cdd:TIGR01299 282 EFLAQEKRGehlswlcmfWMIGGIYAAAMAWAIIphygwSFQMGSayqFHSWRVfVIVCA--FPcVFAIGALTFMPESPR 359
                         170       180
                  ....*....|....*....|....*.
gi 45445390   240 WLLRNGHEKRALQALSFLRGSEISAQ 265
Cdd:TIGR01299 360 FFLENGKHDEAWMILKLIHDTNMRAK 385
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
83-169 7.60e-05

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 44.88  E-value: 7.60e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  83 LPQLMdnnsTEIPIDVETGSWIASVHSLATPFGSLLSGPLADYLGRRRTLILSVIPLLLGWSTLAIAKSIKVVIFARFLC 162
Cdd:cd17504  19 LPTIQ----REFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQ 94

                ....*..
gi 45445390 163 GFATGIL 169
Cdd:cd17504  95 GIGGAVF 101
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
73-218 9.89e-05

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 44.62  E-value: 9.89e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  73 GMPIGFSAILLPQLMDNNSteipIDVETGSWIASVHSLATPFGSLLSGPLADYLGRRRTLILSVIPLLLGWSTLAIAKSI 152
Cdd:cd17333   9 GLTDALLGILGPSLEEAFN----LNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSI 84
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 45445390 153 KVVIFARFLCGFATGILGGPGQVYIAeTAEPNLRSLLIGAPYVAYSSGILMVYSLGSMMYWRSVAW 218
Cdd:cd17333  85 YLFVVLMFLAGLGAGILDTGANTFVG-ALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELSW 149
MFS_1 pfam07690
Major Facilitator Superfamily;
64-203 1.37e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 44.33  E-value: 1.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390    64 AVLLLSAGCGMPIGFSAI--LLPQLMDnnstEIPIDVETGSWIASVHSLATPFGSLLSGPLADYLGRRRTLILSV---IP 138
Cdd:pfam07690 202 VLWLLLALLLFGFAFFGLltYLPLYQE----VLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALlllIL 277
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 45445390   139 LLLGWSTLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETAEPNLRSLLIGAPYVAYSSGILM 203
Cdd:pfam07690 278 AALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGAL 342
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
80-218 2.47e-04

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 43.32  E-value: 2.47e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  80 AILLPQLMDnnstEIPIDVETGSWIASVHSLATPFGSLLSGPLADYLGRRRTLILSVIPLLLGWSTLAIAKSIKVVIFAR 159
Cdd:cd17321  16 NVALPTIAR----DLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAAR 91
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 45445390 160 FLCGFATGILGGPGQVYIAETAEPNLRSLLIGAPYVAYSSGILMVYSLGSMM----YWRSVAW 218
Cdd:cd17321  92 ALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLlelfGWRWIFL 154
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
101-237 4.41e-04

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 42.65  E-value: 4.41e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 101 GSWIASVHSLATPFGSLLSGPLADYLGRRRTLILSVIPLLLGWSTLAIAKSIKVVIFARFLCGFATGILGGPGQVyIAET 180
Cdd:cd17389  66 GGLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAI-VADV 144
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 45445390 181 AEPNLRS---LLIGapyVAYSSGilmvYSLGSMM--------------YWRSVAWCANVLPLLSMVSIS-FIPET 237
Cdd:cd17389 145 TSPKKRSkgmALIG---VAFSLG----FIIGPMIgayfasftrslgevFFSMPALFALVLALADLLFIFfFLPET 212
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
305-489 6.91e-04

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 41.88  E-value: 6.91e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 305 IVFSLLQMFSGTFI-VIFYAVDMiSEFGAEFDSKQAAIATAVVRVICCMVFCVVLIFVRRRRIMIVSG-IGSGLFCLVLS 382
Cdd:cd17364 210 IAFYGQNLFQSTIIsAIGFSKTM-NAYQELFNIAVGQLIIALAGTVPGYWFTVFLIDRIGRKKIQMMGfFGMTIFLLILA 288
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 383 VYqyarFDQPKMSYDVFVgAGCLLGYIIFNTALMVMPGIMIGELFPARIRGRTAGGVFASMNVALFIFAKKFPALQAMLK 462
Cdd:cd17364 289 GP----YDHWKISTIGFF-VLYGLTFFFSNFGPNTTTFIVPAEVFPARVRSTCHGISAASGKIGAIVGSFLFLSLTQNIG 363
                       170       180
                ....*....|....*....|....*..
gi 45445390 463 MRGVFLVFGVSSfLLTAFMCLFQPETK 489
Cdd:cd17364 364 VRNVLIILAGVA-LLGIILTLLFPEEK 389
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
104-191 7.00e-04

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 41.83  E-value: 7.00e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 104 IASVHSLATPFGSLLSGPLADYLGRRRTLILSVIPLLLGWSTLAIAKSIKVVIFARFLCGFATGILGGpGQVYIAETAEP 183
Cdd:cd17390  36 IGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFKHTQSL-CKAYLSDLVSE 114

                ....*...
gi 45445390 184 NLRSLLIG 191
Cdd:cd17390 115 QERSRVLG 122
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
115-267 9.53e-04

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 41.83  E-value: 9.53e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 115 GSLLSGPLADYLGRRRTLILSVIPLLLGWSTLAIAKSIKVVIFARFLCGFAtgiLGGPGQVYIAETAEPNLRS------- 187
Cdd:cd17438  50 GAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLFCRLISGFG---IGGSLPIVFAYFSEFLAREkrgehls 126
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 188 -----LLIGAPYV-AYSSGILMVYSLGSMM-------YWRS-VAWCAnvLP-LLSMVSISFIPETPAWLLRNGHEKRALQ 252
Cdd:cd17438 127 wlcmfWMIGGLYAsAMAWSIIPHYGWGFSMgtnyhfhSWRVfVIICA--LPcIASIIALKFMPESPRFLLEMGKHDEAWM 204
                       170
                ....*....|....*
gi 45445390 253 ALSFLRGSEISAQKE 267
Cdd:cd17438 205 ILKNIHDTNMRAKGT 219
MFS_SLC22A17 cd17445
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ...
75-204 1.25e-03

Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341003 [Multi-domain]  Cd Length: 346  Bit Score: 41.30  E-value: 1.25e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  75 PIGFSAILLPQLMDNNSTEIPIDVETGsWIASVHS----LATPFGSLLSGPLADYLGRRRTLILSVIPLLLGWSTLAIAK 150
Cdd:cd17445   9 DAGWNYTGLPGLTNNIVTEWDLVCSRY-WLVPLEQvcfiLGFASGYLCLGYTADRLGRRRTLLLSLTLAVPFGVLVAVAA 87
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 45445390 151 SIKVVIFARFLCGFATGilGGPGQVYIA--ETAEPNLRSLligapyVAYSSGILMV 204
Cdd:cd17445  88 SPSLFMAMRFLLGAALA--GVYLTLYLTrlELCDPPQRLL------VAMAGGLTMV 135
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
102-238 1.37e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 41.02  E-value: 1.37e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 102 SWIASVHSLATPFGSLLSGPLADYLGRRRTLILSVIPLLLGWSTLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETA 181
Cdd:cd17474  37 GLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLF 116
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 182 EPNLRSLLIGAPYVAYSSGILMVYSLGS---MMYWRSVAWCANVLPLLSMVSISFIPETP 238
Cdd:cd17474 117 EGGERAKAMGLYEAALGLGIAVGPLLGGllaAISWRYPFFLLAALIPVAFLAILFLLPEP 176
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
114-229 1.44e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 41.00  E-value: 1.44e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 114 FGSLLSGPLADYLGRRRTLILSVIPLLLGWSTLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETAePNLRSLLIGAP 193
Cdd:cd17324 249 VGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLA-PEARGLASSLY 327
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 45445390 194 YVAYSSGILMVYSLGSMMY----WRSVAWCANVLPLLSMV 229
Cdd:cd17324 328 LAAYNLGGALGAALGGLVLdhggWAGVGWVGAALLLLALL 367
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
92-267 1.79e-03

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 41.05  E-value: 1.79e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  92 TEIPIDVETGSWIASVHSLATPFGSLLSGPLADYLGRRRTLI--LSVIPLLLGWSTLaiAKSIKVVIFARFLCGFATGIL 169
Cdd:cd17440  27 TDMCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLicMSVNGFFAFLSSF--VQGYGLFLFCRLLSGFGIGGA 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 170 GGPGQVYIAETAEPNLRS---------LLIGAPYVAYSSGILM-----VYSLGSMMYWRS----VAWCAnvLPLLS-MVS 230
Cdd:cd17440 105 VPTVFSYFAEVLAREKRGehlswlcmfWMIGGIYASAMAWAIIphygwSFSMGSAYQFHSwrvfVIVCA--LPCVSsVVA 182
                       170       180       190
                ....*....|....*....|....*....|....*..
gi 45445390 231 ISFIPETPAWLLRNGHEKRALQALSFLRGSEISAQKE 267
Cdd:cd17440 183 LTFMPESPRFLLEVGKHDEAWMILKQIHDTNMRARGQ 219
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
305-517 2.27e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 40.49  E-value: 2.27e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 305 IVFSLLQMFSGTFIVIFYAVDMISEFGaeFDSKQAAIATAVVRVICcMVFCVVLIFV----RRRRIMIVSGIGSGLFCLV 380
Cdd:cd06174   1 LLLGFFLTGLARGLISPLLPALLQSFG--LSASQLGLLFALFSLGY-ALLQPLAGLLadrfGRRPVLLLGLLLFALGALL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 381 LSVYQyarfdqpkmSYDVFVGAGCLLGyiIFNTALMVMPGIMIGELFPARIRGR----TAGGVFASMNVALFIFAkkFPA 456
Cdd:cd06174  78 FAFAP---------SFWLLLLGRFLLG--LGSGLIDPAVLALIADLFPERERGRalglLQAFGSVGGILGPLLGG--ILA 144
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 45445390 457 LQAMLKMRGVFLVFGVSSFLLTAFMCLFQPETKGRSLEHIEDYFNGDNWLWFRRDRGYKTV 517
Cdd:cd06174 145 SSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGL 205
2A0109 TIGR00887
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ...
100-496 2.99e-03

phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]


Pssm-ID: 129965 [Multi-domain]  Cd Length: 502  Bit Score: 40.10  E-value: 2.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390   100 TGSWIASVHSLATPFGSLLSGPLADYLGRRR----TLILSVI-PLLLGWSTLAIAKS-IKVVIFARFLCGFatGIlGG-- 171
Cdd:TIGR00887  57 VSAAVNGSASIGTLAGQLFFGWLADKLGRKRvygmELIIMIIaTVASGLSPGSSPKSvMATLCFWRFWLGV--GI-GGdy 133
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390   172 PGQVYI-AETAEPNLRSLLIGAPYV-----AYSSGILMVYSLGSM----------------------MYWRSVAWCANVL 223
Cdd:TIGR00887 134 PLSAIItSEFATKKWRGAMMAAVFAmqgfgILAGAIVALIVLAGFkhsleaaadeasctgscvpavdYMWRILIGFGAVP 213
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390   224 PLLSMVSISFIPETPAWLLRngHEKRALQAlsflrGSEISAQKELN-----DMKQRLAKERVTTKTN-ENIFQLCCQRVA 297
Cdd:TIGR00887 214 ALLALYFRLTIPETPRYTAD--VAKDVEQA-----ASDMSAVLQVKieaepDEVEKASTAVEVPKASwSDFFTHFFKWRH 286
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390   298 IKPLV--------IVIVFSLLQMFSGT-FIVIFYavdmiSEFGAEFDSKQAAIATAV---VRVICCMV----FCVVLIFV 361
Cdd:TIGR00887 287 GKHLLgtagswflLDIAFYGVNLNQKViLSAIGY-----SPPAATNNAYEELYKTAVgnlIIALAGTVpgywVTVFLVDI 361
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390   362 RRRRIMIVSGIG-SGLFCLVLSVyqyarfdqpkmSYDVFVGAGCLLGYIIF--------NTALMVMPgimiGELFPARIR 432
Cdd:TIGR00887 362 IGRKPIQLMGFFiLTVLFFVLGF-----------AYNHLSTHGFLAIYVLAqffanfgpNATTFIVP----GEVFPTRYR 426
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 45445390   433 GrTAGGVFASMNVA-------LFIFAKKFPALQ----AMLKMRGVFLVFGVSSFLLTAFMCLFqPETKGRSLEHI 496
Cdd:TIGR00887 427 S-TAHGISAASGKAgaiigqfGFLYLAQHGDPTkgypTGIWMGHVLEIFALFMFLGILFTLLI-PETKGKSLEEL 499
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
302-481 3.30e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 39.85  E-value: 3.30e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 302 VIVIVFSLLQMFSGTFIVIF--YAVDMISEFGaeFDSKQAAIATA---VVRVICCMVFCVVLIFVRRRRIMIVSGIGSGL 376
Cdd:COG2271  10 RILALLFLAYFLNYLDRSNLsvAAPPLQADLG--LSAAQLGLLASaffLGYALGQIPAGLLADRFGRRRVLAIGLLLWGL 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 377 FCLVLSVYQyarfdqpkmSYDVFVGAGCLLGyiIFNTALMVMPGIMIGELFPARIRGRTAGGVFASMNVALFIFAKKFPA 456
Cdd:COG2271  88 ATLLFGFAT---------SFWQLLLLRFLLG--LGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGW 156
                       170       180
                ....*....|....*....|....*
gi 45445390 457 LQAMLKMRGVFLVFGVSSFLLTAFM 481
Cdd:COG2271 157 LLAAFGWRAAFLILGLPGLLLALLR 181
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
113-213 4.58e-03

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 39.51  E-value: 4.58e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 113 PFGSLlsgplADYLGRRRTLILSVIPLLLGWSTLAIAKSIKVVIFARFLCGfaTGILGGPGQVYIAETAEPNLRSL---L 189
Cdd:cd17472  51 PFGLL-----SDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQG--SGAISSVVMALLADLTREENRTKamaL 123
                        90       100       110
                ....*....|....*....|....*....|
gi 45445390 190 IGAPY-----VAYSSGILMVYSLG-SMMYW 213
Cdd:cd17472 124 IGASIgiafaISMVLGPLLAAHLGvSGLFL 153
MFS_ProP cd17366
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ...
106-189 4.82e-03

Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340924 [Multi-domain]  Cd Length: 377  Bit Score: 39.26  E-value: 4.82e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 106 SVHSLATPFGSLLSGPLADYLGRRRtlILSVIPLLLGWSTLAIA-----KSIKVV-----IFARFLCGFATGILGGPGQV 175
Cdd:cd17366  47 AVAFLVRPLGGLVFGPLGDKYGRQK--VLAITIILMAASTFCIGllptyATIGVWapillLLARMVQGFSTGGEYGGAAT 124
                        90
                ....*....|....
gi 45445390 176 YIAETAEPNLRSLL 189
Cdd:cd17366 125 FVAEYAPDRKRGFL 138
MFS_YjiJ cd06180
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ...
73-239 5.36e-03

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340869 [Multi-domain]  Cd Length: 371  Bit Score: 39.21  E-value: 5.36e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  73 GMPIG--FSAILLPQLMDnnstEIPIDVETGSWIASVHSLATPFGSLLSGPLADYLGRRRTLILSVIPLLLGWSTLAIAK 150
Cdd:cd06180  10 AMGIGrfAYTPLLPLMLA----ELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 151 SIKVVIFARFLCGFATGILGGPGQVYIAETAEPNLRSLLIGAPYVAYSSGILM---------VYSLGSMMYWRSVAWCAN 221
Cdd:cd06180  86 GFAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALsgllvpaglGGGLSWRAGWLALALLSA 165
                       170
                ....*....|....*...
gi 45445390 222 VLPLLSMVSISFIPETPA 239
Cdd:cd06180 166 VLLLLSFLLLRRGPSAPT 183
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
115-200 5.99e-03

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 38.81  E-value: 5.99e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 115 GSLLSGPLADYLGRRRTLILSVIPLLLGWSTLAIAKSIKVVIFARFLCGFATGILGGPGQVYIAETAEPNLRSLLIGAPY 194
Cdd:cd17374  51 GALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHRALAITLTS 130

                ....*.
gi 45445390 195 VAYSSG 200
Cdd:cd17374 131 CFFSIG 136
PRK12307 PRK12307
MFS transporter;
77-240 6.80e-03

MFS transporter;


Pssm-ID: 237051 [Multi-domain]  Cd Length: 426  Bit Score: 39.14  E-value: 6.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390   77 GFSAILLPQLMDNNSTEIPIDVETGSWIASVHSLATPFGSLLSGPLADYLGRRRTLILSVIPLLLGWSTLAIAKSIKVVI 156
Cdd:PRK12307  31 GFDFMLIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLT 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390  157 FARFLCGFATGILGGPGQVYIAETAEPNLRSLLIGAPYVAYSSG-ILMVY---SLGSMMYWRSvAWCANVLPLLSMVSI- 231
Cdd:PRK12307 111 LSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGnIIAAYfmpSFAEAYGWRA-AFFVGLLPVLLVIYIr 189

                 ....*....
gi 45445390  232 SFIPETPAW 240
Cdd:PRK12307 190 ARAPESKEW 198
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
114-165 7.57e-03

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 38.74  E-value: 7.57e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 45445390  114 FGSLLSGPLADYLGRRRTLILSVIPLLLGWSTLAIAKSIKVVIFARFLCGFA 165
Cdd:PRK11102  41 IGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
110-167 8.47e-03

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 38.71  E-value: 8.47e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 45445390 110 LATPFGSLLSGPLADYLGRRRTLILSVIPLLLGWSTLAIAKSIKVVIFARFLCGFATG 167
Cdd:cd17320  45 LGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAA 102
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
103-254 9.13e-03

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 38.62  E-value: 9.13e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 103 WIASVHSLATPFGSLLSGPLADYLGRRRTLILSVIPLLLGWSTLAIAKSIKVVIFARFLCGFatGILGGPGQV--YIAET 180
Cdd:cd17363  38 MLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYGFFLFCRLLSGI--GIGGSIPIVfsYFAEF 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45445390 181 AEPNLRS---------LLIGAPYVAYSS-GILMVYSLGSMM-------YWRS-VAWCAnvLP-LLSMVSISFIPETPAWL 241
Cdd:cd17363 116 LAREKRGehlswlcmfWMIGGLYASAMAwAIIPHYGWGFSMgtayqfhSWRVfVIVCA--LPsVASVVALTFMPESPRFL 193
                       170
                ....*....|...
gi 45445390 242 LRNGHEKRALQAL 254
Cdd:cd17363 194 LEVGKHDEAWMIL 206
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH
HHS Vulnerability Disclosure