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Conserved domains on  [gi|21280973|gb|AAM45064|]
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putative heme A [Arabidopsis thaliana]

Protein Classification

protoheme IX farnesyltransferase( domain architecture ID 10791459)

protoheme IX farnesyltransferase acts in step 1 of the conversion protoheme IX to heme O in heme O biosynthesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN02776 PLN02776
prenyltransferase
 101-431 0e+00

prenyltransferase


:

Pssm-ID: 215415  Cd Length: 341  Bit Score: 574.00  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973  101 LSKAKLSMLVVATSGTGYILGTGNAaISFPGLCYTCAGTMMIAASANSLNQIFEISNDSKMKRTMLRPLPSGRISVPHAV 180
Cdd:PLN02776   1 LSKARLSALVVATSGAGFVLGSGEA-IDLPGLGWTCAGTMLCAASANTLNQVFEVKNDSKMKRTMRRPLPSGRISVPHAV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973  181 AWATIAGASGACLLASKTNMLAAGLASANLVLYAFVYTPLKQLHPINTWVGAVVGAIPPLLGWAAASGQISYNSMILPAA 260
Cdd:PLN02776  80 AWAVVVGAAGVALLAYKTNMLTAGLGAGNILLYAFVYTPLKQIHPANTWVGAVVGAIPPLMGWAAASGQLDAGAMVLAAA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973  261 LYFWQIPHFMALAHLCRNDYAAGGYKMLSLFDPSGKRIAAVALRNCFYMIPLGFIAYDWGLTSSWFCLESTLLTLAIAAT 340
Cdd:PLN02776 160 LYFWQMPHFMALAYMCRDDYAAGGYRMLSLADATGRRTALVALRNCLYLAPLGFLAYDWGVTSSPFALEAALLTAYLAAS 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973  341 AFSFYRDRTMHKARKMFHASLLFLPVFMSGLLLHRVSNDNQQQLVE-----------EAGLTNSVSGEVKTQRRKKRVAQ 409
Cdd:PLN02776 240 AASFYREPTNANARKMFHGSLLYLPAFMALLLLHRVPNDNQVDLRQeseltesldgrAKGREETSLEQVSKRRAPGRVAR 319

                        330       340
                 ....*....|....*....|..
gi 21280973  410 PPVAYASAAPFPFLPAPSFYSP 431
Cdd:PLN02776 320 PPVAYASAAPFPFLPAPSYASP 341
 
Name Accession Description Interval E-value
PLN02776 PLN02776
prenyltransferase
 101-431 0e+00

prenyltransferase


Pssm-ID: 215415  Cd Length: 341  Bit Score: 574.00  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973  101 LSKAKLSMLVVATSGTGYILGTGNAaISFPGLCYTCAGTMMIAASANSLNQIFEISNDSKMKRTMLRPLPSGRISVPHAV 180
Cdd:PLN02776   1 LSKARLSALVVATSGAGFVLGSGEA-IDLPGLGWTCAGTMLCAASANTLNQVFEVKNDSKMKRTMRRPLPSGRISVPHAV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973  181 AWATIAGASGACLLASKTNMLAAGLASANLVLYAFVYTPLKQLHPINTWVGAVVGAIPPLLGWAAASGQISYNSMILPAA 260
Cdd:PLN02776  80 AWAVVVGAAGVALLAYKTNMLTAGLGAGNILLYAFVYTPLKQIHPANTWVGAVVGAIPPLMGWAAASGQLDAGAMVLAAA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973  261 LYFWQIPHFMALAHLCRNDYAAGGYKMLSLFDPSGKRIAAVALRNCFYMIPLGFIAYDWGLTSSWFCLESTLLTLAIAAT 340
Cdd:PLN02776 160 LYFWQMPHFMALAYMCRDDYAAGGYRMLSLADATGRRTALVALRNCLYLAPLGFLAYDWGVTSSPFALEAALLTAYLAAS 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973  341 AFSFYRDRTMHKARKMFHASLLFLPVFMSGLLLHRVSNDNQQQLVE-----------EAGLTNSVSGEVKTQRRKKRVAQ 409
Cdd:PLN02776 240 AASFYREPTNANARKMFHGSLLYLPAFMALLLLHRVPNDNQVDLRQeseltesldgrAKGREETSLEQVSKRRAPGRVAR 319

                        330       340
                 ....*....|....*....|..
gi 21280973  410 PPVAYASAAPFPFLPAPSFYSP 431
Cdd:PLN02776 320 PPVAYASAAPFPFLPAPSYASP 341
cyoE_ctaB TIGR01473
protoheme IX farnesyltransferase; This model describes protoheme IX farnesyltransferase, also ...
 96-374 4.87e-104

protoheme IX farnesyltransferase; This model describes protoheme IX farnesyltransferase, also called heme O synthase, an enzyme that creates an intermediate in the biosynthesis of heme A. Prior to the description of its enzymatic function, this protein was often called a cytochrome o ubiquinol oxidase assembly factor. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 273645  Cd Length: 280  Bit Score: 309.95  E-value: 4.87e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973    96 RCYWELSKAKLSMLVVATSGTGYILGTGNAAISFPGLCYTCAGTMMIAASANSLNQIFEISNDSKMKRTMLRPLPSGRIS 175
Cdd:TIGR01473   1 KDYLQLTKPRIISLLLITAFAGMWLAPGGALVNPPLLLLTLLGTTLAAASANAFNMYIDRDIDKKMKRTRNRPLVTGRIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973   176 VPHAVAWATIAGASGACLLASKTNMLAAGLASANLVLYAFVYT-PLKQLHPINTWVGAVVGAIPPLLGWAAASGQISYNS 254
Cdd:TIGR01473  81 PREALAFGLLLGVLGVAILAAFVNPLAALLGLFGIFFYVIVYTiWLKRRTPQNTVIGGFAGAVPPLIGWAAVTGSISLGA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973   255 MILPAALYFWQIPHFMALAHLCRNDYAAGGYKMLSLFDPSGKRIAAVALRnCFYMIPLGFIAYDWGLTSSWFCLESTLLT 334
Cdd:TIGR01473 161 WLLFAIIFLWQPPHFWALALKYKDDYRAAGIPMLPVVKGERITKRQIALY-TAALLPVSLLLAFLGGTGWLYLIVATLLG 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 21280973   335 LAIAATAFSFYRDRTMH-KARKMFHASLLFLPVFMSGLLLH 374
Cdd:TIGR01473 240 ALFLYLAFKFYRDPTDRkKARKLFKFSLIYLALLFVALLID 280
PT_UbiA_Cox10 cd13957
Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase (also called heme O ...
 99-368 3.69e-99

Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase (also called heme O synthase, heme A:farnesyltransferase, cytochrome c oxidase subunit X [Cox10]) converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of the heme B porphyrin ring with a hydroxyethyl farnesyl side group. It is localized at the mitochondrial inner membrane. Eukaryotic Cox10 is important for the maturation of the heme A prosthetic group of cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, that catalyzes the electron transfer from reduced cytochrome c to oxygen. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260120  Cd Length: 271  Bit Score: 297.04  E-value: 3.69e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973  99 WELSKAKLSMLVVATSGTGYILGTGnAAISFPGLCYTCAGTMMIAASANSLNQIFEISNDSKMKRTMLRPLPSGRISVPH 178
Cdd:cd13957   1 LELTKPRITLLVLLTALAGYLLAPG-GVPDLLLLLLTLLGTALVSASANALNQYIERDIDAKMKRTRNRPLPSGRISPKH 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973 179 AVAWATIAGASGACLLASKTNMLAAGLASANLVLYAFVYTPLKQLH-PINTWVGAVVGAIPPLLGWAAASGQISYNSMIL 257
Cdd:cd13957  80 ALIFGLVLGILGLALLALFVNPLTALLGLLGIFLYVFVYTPLKKRTtPLNTVIGGIAGAIPPLIGWAAATGSLDLGAWLL 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973 258 PAALYFWQIPHFMALAHLCRNDYAAGGYKMLSLFDPSGKRIAAvALRNCFYMIPLGFIAYDWGLTSSWFCLESTLLTLAI 337
Cdd:cd13957 160 FLILFLWQPPHFWALAILYRDDYARAGIPMLPVVKGERRTKRQ-ILLYTLLLVPLSLLLYLLGLTGWIYLVVALLLGLYF 238

                       250       260       270
                ....*....|....*....|....*....|.
gi 21280973 338 AATAFSFYRDRTMHKARKMFHASLLFLPVFM 368
Cdd:cd13957 239 LYLAIKLYRSPDDKWARKLFFASLIYLPLLF 269
CyoE COG0109
Polyprenyltransferase (heme O synthase) [Coenzyme transport and metabolism, Lipid transport ...
 98-373 6.75e-76

Polyprenyltransferase (heme O synthase) [Coenzyme transport and metabolism, Lipid transport and metabolism];


Pssm-ID: 439879  Cd Length: 299  Bit Score: 238.49  E-value: 6.75e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973  98 YWELSKAKLSMLVVATSGTGYILGTGnAAISFPGLCYTCAGTMMIAASANSLNQIFEISNDSKMKRTMLRPLPSGRISVP 177
Cdd:COG0109  19 YLALTKPRIILLLLFTALAGMLLAAG-GLPDLLLLLLTLLGGALAAGAANALNNYIDRDIDALMKRTKNRPLPTGRISPR 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973 178 HAVAWATIAGASGACLLASKTNMLAAGLASANLVLYAFVYTP-LKQLHPINTWVGAVVGAIPPLLGWAAASGQISYNSMI 256
Cdd:COG0109  98 EALIFGLVLGVLGLALLALFVNPLAALLGLLGIFFYVVVYTLwLKRRTPQNIVIGGAAGAMPPLIGWAAVTGSLSLEALL 177

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973 257 LPAALYFWQIPHFMALAHLCRNDYAAGGYKMLslfdPSGKRIAAVALRNCFY---MIPLGFIAYDWGLTSSWFCLESTLL 333
Cdd:COG0109 178 LFLIIFLWTPPHFWALALKRRDDYARAGVPML----PVVKGERRTKRQILLYtllLVPVSLLPYLLGMAGLIYLVVALVL 253

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 21280973 334 TLAIAATAFSFYRDRTMHKARKMFHASLLFLPVFMSGLLL 373
Cdd:COG0109 254 GAWFLYLAVRLYRRPDRKWARKLFKFSILYLTLLFLALLV 293
UbiA pfam01040
UbiA prenyltransferase family;
110-361 2.68e-39

UbiA prenyltransferase family;


Pssm-ID: 460038 [Multi-domain]  Cd Length: 250  Bit Score: 141.60  E-value: 2.68e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973   110 VVATSGTGYILGTGnAAISFPGLCYTCAGTMMIAASANSLNQIFEISNDSKMKRTMLRPLPSGRISVPHAVAWATIAGAS 189
Cdd:pfam01040   1 LLIPALAGLALAAG-GVPDLLLLLLALLGTVLARAAANALNDYYDRDIDAIMPRTPNRPLPSGRISPREALIFALVLLAL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973   190 GACLLASkTNMLAAGLASANLVLYaFVYT-PLKQLHPINTWVGAVVGAIPPLLGWAAASGQISYNSMILPAALYFWQIPH 268
Cdd:pfam01040  80 GLLLLLL-LNPLTALLGLAALLLY-VLYTlRLKRRTLLGQLVGGLAFGLPPLLGWAAVTGSLSPLALLLALALFLWTWAI 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973   269 FMALAHLCRNDYAAGGYKMLSLfdpsgkRIAAVALRNCFYMIPLGFIAYDWGLTSSWFCLESTLLTLAIAATAFSFY--- 345
Cdd:pfam01040 158 ALANDLRDREDDRKAGIKTLPV------VLGRKAARILLALLLAVALLLLLLLLLLLLGGLYLLLALLLAALALLYAarl 231

                         250
                  ....*....|....*....
gi 21280973   346 ---RDRTMHKARKMFHASL 361
Cdd:pfam01040 232 lrlRDPKKDAKAFFFLSSL 250
 
Name Accession Description Interval E-value
PLN02776 PLN02776
prenyltransferase
 101-431 0e+00

prenyltransferase


Pssm-ID: 215415  Cd Length: 341  Bit Score: 574.00  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973  101 LSKAKLSMLVVATSGTGYILGTGNAaISFPGLCYTCAGTMMIAASANSLNQIFEISNDSKMKRTMLRPLPSGRISVPHAV 180
Cdd:PLN02776   1 LSKARLSALVVATSGAGFVLGSGEA-IDLPGLGWTCAGTMLCAASANTLNQVFEVKNDSKMKRTMRRPLPSGRISVPHAV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973  181 AWATIAGASGACLLASKTNMLAAGLASANLVLYAFVYTPLKQLHPINTWVGAVVGAIPPLLGWAAASGQISYNSMILPAA 260
Cdd:PLN02776  80 AWAVVVGAAGVALLAYKTNMLTAGLGAGNILLYAFVYTPLKQIHPANTWVGAVVGAIPPLMGWAAASGQLDAGAMVLAAA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973  261 LYFWQIPHFMALAHLCRNDYAAGGYKMLSLFDPSGKRIAAVALRNCFYMIPLGFIAYDWGLTSSWFCLESTLLTLAIAAT 340
Cdd:PLN02776 160 LYFWQMPHFMALAYMCRDDYAAGGYRMLSLADATGRRTALVALRNCLYLAPLGFLAYDWGVTSSPFALEAALLTAYLAAS 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973  341 AFSFYRDRTMHKARKMFHASLLFLPVFMSGLLLHRVSNDNQQQLVE-----------EAGLTNSVSGEVKTQRRKKRVAQ 409
Cdd:PLN02776 240 AASFYREPTNANARKMFHGSLLYLPAFMALLLLHRVPNDNQVDLRQeseltesldgrAKGREETSLEQVSKRRAPGRVAR 319

                        330       340
                 ....*....|....*....|..
gi 21280973  410 PPVAYASAAPFPFLPAPSFYSP 431
Cdd:PLN02776 320 PPVAYASAAPFPFLPAPSYASP 341
cyoE_ctaB TIGR01473
protoheme IX farnesyltransferase; This model describes protoheme IX farnesyltransferase, also ...
 96-374 4.87e-104

protoheme IX farnesyltransferase; This model describes protoheme IX farnesyltransferase, also called heme O synthase, an enzyme that creates an intermediate in the biosynthesis of heme A. Prior to the description of its enzymatic function, this protein was often called a cytochrome o ubiquinol oxidase assembly factor. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 273645  Cd Length: 280  Bit Score: 309.95  E-value: 4.87e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973    96 RCYWELSKAKLSMLVVATSGTGYILGTGNAAISFPGLCYTCAGTMMIAASANSLNQIFEISNDSKMKRTMLRPLPSGRIS 175
Cdd:TIGR01473   1 KDYLQLTKPRIISLLLITAFAGMWLAPGGALVNPPLLLLTLLGTTLAAASANAFNMYIDRDIDKKMKRTRNRPLVTGRIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973   176 VPHAVAWATIAGASGACLLASKTNMLAAGLASANLVLYAFVYT-PLKQLHPINTWVGAVVGAIPPLLGWAAASGQISYNS 254
Cdd:TIGR01473  81 PREALAFGLLLGVLGVAILAAFVNPLAALLGLFGIFFYVIVYTiWLKRRTPQNTVIGGFAGAVPPLIGWAAVTGSISLGA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973   255 MILPAALYFWQIPHFMALAHLCRNDYAAGGYKMLSLFDPSGKRIAAVALRnCFYMIPLGFIAYDWGLTSSWFCLESTLLT 334
Cdd:TIGR01473 161 WLLFAIIFLWQPPHFWALALKYKDDYRAAGIPMLPVVKGERITKRQIALY-TAALLPVSLLLAFLGGTGWLYLIVATLLG 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 21280973   335 LAIAATAFSFYRDRTMH-KARKMFHASLLFLPVFMSGLLLH 374
Cdd:TIGR01473 240 ALFLYLAFKFYRDPTDRkKARKLFKFSLIYLALLFVALLID 280
PT_UbiA_Cox10 cd13957
Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase (also called heme O ...
 99-368 3.69e-99

Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase (also called heme O synthase, heme A:farnesyltransferase, cytochrome c oxidase subunit X [Cox10]) converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of the heme B porphyrin ring with a hydroxyethyl farnesyl side group. It is localized at the mitochondrial inner membrane. Eukaryotic Cox10 is important for the maturation of the heme A prosthetic group of cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, that catalyzes the electron transfer from reduced cytochrome c to oxygen. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260120  Cd Length: 271  Bit Score: 297.04  E-value: 3.69e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973  99 WELSKAKLSMLVVATSGTGYILGTGnAAISFPGLCYTCAGTMMIAASANSLNQIFEISNDSKMKRTMLRPLPSGRISVPH 178
Cdd:cd13957   1 LELTKPRITLLVLLTALAGYLLAPG-GVPDLLLLLLTLLGTALVSASANALNQYIERDIDAKMKRTRNRPLPSGRISPKH 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973 179 AVAWATIAGASGACLLASKTNMLAAGLASANLVLYAFVYTPLKQLH-PINTWVGAVVGAIPPLLGWAAASGQISYNSMIL 257
Cdd:cd13957  80 ALIFGLVLGILGLALLALFVNPLTALLGLLGIFLYVFVYTPLKKRTtPLNTVIGGIAGAIPPLIGWAAATGSLDLGAWLL 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973 258 PAALYFWQIPHFMALAHLCRNDYAAGGYKMLSLFDPSGKRIAAvALRNCFYMIPLGFIAYDWGLTSSWFCLESTLLTLAI 337
Cdd:cd13957 160 FLILFLWQPPHFWALAILYRDDYARAGIPMLPVVKGERRTKRQ-ILLYTLLLVPLSLLLYLLGLTGWIYLVVALLLGLYF 238

                       250       260       270
                ....*....|....*....|....*....|.
gi 21280973 338 AATAFSFYRDRTMHKARKMFHASLLFLPVFM 368
Cdd:cd13957 239 LYLAIKLYRSPDDKWARKLFFASLIYLPLLF 269
CyoE COG0109
Polyprenyltransferase (heme O synthase) [Coenzyme transport and metabolism, Lipid transport ...
 98-373 6.75e-76

Polyprenyltransferase (heme O synthase) [Coenzyme transport and metabolism, Lipid transport and metabolism];


Pssm-ID: 439879  Cd Length: 299  Bit Score: 238.49  E-value: 6.75e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973  98 YWELSKAKLSMLVVATSGTGYILGTGnAAISFPGLCYTCAGTMMIAASANSLNQIFEISNDSKMKRTMLRPLPSGRISVP 177
Cdd:COG0109  19 YLALTKPRIILLLLFTALAGMLLAAG-GLPDLLLLLLTLLGGALAAGAANALNNYIDRDIDALMKRTKNRPLPTGRISPR 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973 178 HAVAWATIAGASGACLLASKTNMLAAGLASANLVLYAFVYTP-LKQLHPINTWVGAVVGAIPPLLGWAAASGQISYNSMI 256
Cdd:COG0109  98 EALIFGLVLGVLGLALLALFVNPLAALLGLLGIFFYVVVYTLwLKRRTPQNIVIGGAAGAMPPLIGWAAVTGSLSLEALL 177

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973 257 LPAALYFWQIPHFMALAHLCRNDYAAGGYKMLslfdPSGKRIAAVALRNCFY---MIPLGFIAYDWGLTSSWFCLESTLL 333
Cdd:COG0109 178 LFLIIFLWTPPHFWALALKRRDDYARAGVPML----PVVKGERRTKRQILLYtllLVPVSLLPYLLGMAGLIYLVVALVL 253

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 21280973 334 TLAIAATAFSFYRDRTMHKARKMFHASLLFLPVFMSGLLL 373
Cdd:COG0109 254 GAWFLYLAVRLYRRPDRKWARKLFKFSILYLTLLFLALLV 293
PRK04375 PRK04375
protoheme IX farnesyltransferase; Provisional
 98-373 1.32e-53

protoheme IX farnesyltransferase; Provisional


Pssm-ID: 235293  Cd Length: 296  Bit Score: 180.72  E-value: 1.32e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973   98 YWELSKAKLSMLVVATSGTGYILGTGNAaISFPGLCYTCAGTMMIAASANSLNQIFEISNDSKMKRTMLRPLPSGRISVP 177
Cdd:PRK04375  13 YLALTKPRVISLNLFTALGGMLLAPPGV-PPLLLLLLTLLGIALVAGAAGALNNYIDRDIDAKMERTKNRPLVTGRISPR 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973  178 HAVAWATIAGASGACLLASKTNMLAAGLASANLVLYAFVYTP-LKQLHPINTWVGAVVGAIPPLLGWAAASGQISYNSMI 256
Cdd:PRK04375  92 EALIFGLVLGVLGFLLLGLFVNPLAAWLTLAGIFFYVVVYTLwLKRRTPQNIVIGGAAGAMPPLIGWAAVTGSLSWEALI 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973  257 LPAALYFWQIPHFMALAHLCRNDYAAGGYKMLslfdPSGKRIAAVALRNCFY---MIPLGFIAYDWGLTSSWFCLESTLL 333
Cdd:PRK04375 172 LFLIIFLWTPPHFWALAIFRKDDYAAAGIPML----PVVKGIRVTKRQILLYtvlLVAVSLLPVLLGMAGLLYLVVALLL 247

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 21280973  334 TLAIAATAFSFYRDRTMHKARKMFHASLLFLPVFMSGLLL 373
Cdd:PRK04375 248 GAWFLYYAWRLYRKDDRKWARKLFRYSINYLTLLFVALLV 287
UbiA pfam01040
UbiA prenyltransferase family;
110-361 2.68e-39

UbiA prenyltransferase family;


Pssm-ID: 460038 [Multi-domain]  Cd Length: 250  Bit Score: 141.60  E-value: 2.68e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973   110 VVATSGTGYILGTGnAAISFPGLCYTCAGTMMIAASANSLNQIFEISNDSKMKRTMLRPLPSGRISVPHAVAWATIAGAS 189
Cdd:pfam01040   1 LLIPALAGLALAAG-GVPDLLLLLLALLGTVLARAAANALNDYYDRDIDAIMPRTPNRPLPSGRISPREALIFALVLLAL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973   190 GACLLASkTNMLAAGLASANLVLYaFVYT-PLKQLHPINTWVGAVVGAIPPLLGWAAASGQISYNSMILPAALYFWQIPH 268
Cdd:pfam01040  80 GLLLLLL-LNPLTALLGLAALLLY-VLYTlRLKRRTLLGQLVGGLAFGLPPLLGWAAVTGSLSPLALLLALALFLWTWAI 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973   269 FMALAHLCRNDYAAGGYKMLSLfdpsgkRIAAVALRNCFYMIPLGFIAYDWGLTSSWFCLESTLLTLAIAATAFSFY--- 345
Cdd:pfam01040 158 ALANDLRDREDDRKAGIKTLPV------VLGRKAARILLALLLAVALLLLLLLLLLLLGGLYLLLALLLAALALLYAarl 231

                         250
                  ....*....|....*....
gi 21280973   346 ---RDRTMHKARKMFHASL 361
Cdd:pfam01040 232 lrlRDPKKDAKAFFFLSSL 250
UbiA COG0382
4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate ...
 138-266 8.26e-13

4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate polyprenyltransferase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440151  Cd Length: 280  Bit Score: 68.33  E-value: 8.26e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973 138 GTMMIAASANSLNQIFEISNDSKMKRTMLRPLPSGRISVPHAVAWATIAGASGACLLASkTNMLAAGLASANLVLyAFVY 217
Cdd:COG0382  45 GTVLMRSAGYVINDYFDREIDRINERKPNRPLASGRISLREALLLAIVLLLLALALALL-LNPLTFLLALAALAL-AWAY 122

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 21280973 218 TP-LKQLHPI-NTWVGAVVGaIPPLLGWAAASGQISYNSMILPAALYFWQI 266
Cdd:COG0382 123 SLfLKRFTLLgNLVLGLLFG-LGILMGFAAVTGSLPLSAWLLALAAFLWTL 172
PT_UbiA_COQ2 cd13959
4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known ...
 158-266 5.78e-10

4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known as Coq2, catalyzes the prenylation of p-hydroxybenzoate with an all-trans polyprenyl group, an important step in ubiquinone (CoQ) biosynthesis. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260122 [Multi-domain]  Cd Length: 272  Bit Score: 59.79  E-value: 5.78e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973 158 DSKMKRTMLRPLPSGRISVPHAVAWaTIAGASGACLLASKTNMLAAGLASANLVLyAFVY------TPLKQLhpintWVG 231
Cdd:cd13959  61 DAKVPRTKNRPLASGAISVKEALLF-LAVQLLLGLALLLQLNPLTILLSPIALLL-VLIYplmkrfTYWPQL-----VLG 133

                        90       100       110
                ....*....|....*....|....*....|....*
gi 21280973 232 AVVGaIPPLLGWAAASGQISYNSMILPAALYFWQI 266
Cdd:cd13959 134 LAFG-WGPLMGWAAVTGSLPLPALLLYLAVIFWTA 167
PT_UbiA cd13956
UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA ...
 99-373 7.76e-08

UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260119 [Multi-domain]  Cd Length: 271  Bit Score: 53.51  E-value: 7.76e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973  99 WELSKAKLSMLVVATSGTGYILGTGNAAISFPGLCYTCAGTMMIAASANSLNQIFEISNDSKMKRTmlRPLPSGRISVPH 178
Cdd:cd13956   1 LRLMRPYTLLYVLAPALAGAALAGAFAGPLPALLLLALLAVFLGAGAGYALNDYTDRELDAINKPD--RPLPSGRLSPRQ 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973 179 AVAWATIAGASGACLLASkTNMLAAGLASANLVLyAFVYT-PLKQLHPINTWVGAVVGAIPPLLGWAAASGQISYNSMIL 257
Cdd:cd13956  79 ALAFAAALLLVGLALALA-LGPLALLLLLAGLLL-GLAYSlGLKRLKLGGWGVLGYATGLALLPGLGAVAAGGLVPLALL 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973 258 PAALYFWqiphFMALAHLC--RNDY---AAGGYKMLSLFdpSGKRIAAvalRNCFYMIPLGFI----AYDWGLTSSWFcl 328
Cdd:cd13956 157 LALVFLL----LGLGINLYndLPDVegdRAAGIRTLPVR--LGPRRAR---RLAAGLLLAALIlvvlLAVAGLLGPLA-- 225

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 21280973 329 estLLTLAIAATAF---SFYRDRTMHKARKMFHASLLFLPVFMSGLLL 373
Cdd:cd13956 226 ---LLALLAVALLAlraRFARADRLPALPRGFLLLAVYRLLLFAALLL 270
PT_UbiA_DGGGPS cd13961
Geranylgeranylglycerol-phosphate geranylgeranyltransferase; Digeranylgeranylglyceryl phosphate ...
 98-263 4.73e-06

Geranylgeranylglycerol-phosphate geranylgeranyltransferase; Digeranylgeranylglyceryl phosphate synthase (DGGGPS) transfers a geranylgeranyl group from geranylgeranyl diphosphate to (S)-3-O-geranylgeranylglyceryl phosphate to form (S)-2,3-di-O-geranylgeranylglyceryl phosphate, as part of the isoprenoid ether lipid biosynthesis. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260124  Cd Length: 270  Bit Score: 47.88  E-value: 4.73e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973  98 YWELSKAKLS-MLVVATSGTGYILGTGNAAISFPGLCYTCAGTMMIAASANSLNQIFEISNDSKMKRTmlRPLPSGRISV 176
Cdd:cd13961   2 YLELIRPPNLlMAALAQYLGALFALGPLLSLNDLELLLLFLSVFLIAAAGYIINDYFDVEIDRINKPD--RPIPSGRISR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973 177 PHAVAWATIAGASGaCLLASKTNMLAAGLASAN---LVLYAFVytpLKQLHPINTWVGAVVGAIPPLLGWAAASGQIsyN 253
Cdd:cd13961  80 REALILSILLNALG-LILAFLLSPLALLIALLNsllLWLYSHK---LKRTPLIGNLLVALLTGLPFLFGGLAAGNLL--L 153

                       170
                ....*....|
gi 21280973 254 SMILPAALYF 263
Cdd:cd13961 154 IILLLALFAF 163
ubiA PRK12882
prenyltransferase; Reviewed
 95-263 6.56e-05

prenyltransferase; Reviewed


Pssm-ID: 183811  Cd Length: 276  Bit Score: 44.58  E-value: 6.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973   95 ARCYWELSKAKLSMLVVATSGTGYILGTGNAAISFPGLCYTCAgTMMIAASANSLNQIFEISNDsKMKRTMlRPLPSGRI 174
Cdd:PRK12882   4 VRGYLELTRPVNAVVAGVAAFIGAFIAGGILSSPSLTGLAFAA-VFLATGAGNAINDYFDREID-RINRPD-RPIPSGAV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973  175 SVPHAVAWAtIAGASGACLLASKTNMLAAGLASANLVLYAFVYTPLKQLHPI-NTWVGAVVGAIppLLGWAAASGQISYN 253
Cdd:PRK12882  81 SPRGALAFS-ILLFAAGVALAFLLPPLCLAIALFNSLLLVLYAETLKGTPGLgNASVAYLTGST--FLFGGAAVGTEGLL 157

                        170
                 ....*....|
gi 21280973  254 SMILPAALYF 263
Cdd:PRK12882 158 ALLVLFALAA 167
PRK09573 PRK09573
(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase; Reviewed
 142-237 1.44e-03

(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase; Reviewed


Pssm-ID: 181963  Cd Length: 279  Bit Score: 40.33  E-value: 1.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973  142 IAASANSLNQIFEISNDSKMKRTmlRPLPSGRISVPHAVAWATIAGASGACL--LASKTNMLAAGLASANLVLYAFVYtp 219
Cdd:PRK09573  49 VCAGGNVINDIYDIEIDKINKPE--RPIPSGRISLKEAKIFSITLFIVGLILsiFINIYAFLIALLNSILLYLYAKDL-- 124

                         90
                 ....*....|....*....
gi 21280973  220 lKQLHPI-NTWVGAVVGAI 237
Cdd:PRK09573 125 -KKTGLIgNLIVAYLTGLS 142
PT_UbiA_chlorophyll cd13958
Bacteriochlorophyll/chlorophyll synthetase; Chlorophyll synthase catalyzes the last step of ...
 167-264 2.15e-03

Bacteriochlorophyll/chlorophyll synthetase; Chlorophyll synthase catalyzes the last step of chlorophyll (Chl) biosynthesis, the addition of the tetraprenyl (phytyl or geranylgeranyl) side chain. In plant chloroplast, the chlorophyll synthase is located in thylakoid membrane and has been shown to also have a regulatory or channeling function. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260121  Cd Length: 277  Bit Score: 39.91  E-value: 2.15e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973 167 RPLPSGRISVPHAVAWATIAGASGACLLASKTNMLAAGLASANLVL-YAFVYTP--LKQlhpiNTWVG-AVVG----AIP 238
Cdd:cd13958  71 RPIPSGRISEREALWNIWVLLLLSLLVALFLDGPWVFAAAVVGLVLaYIYSAPPlkLKQ----NGWWGnAAVGlsyeGLP 146

                        90       100
                ....*....|....*....|....*.
gi 21280973 239 PLLGWAAASGQISYNSMILpAALYFW 264
Cdd:cd13958 147 WWAGAAAFAGLLTWESLAL-ALLYSI 171
ubiA PRK12884
prenyltransferase; Reviewed
 92-214 2.31e-03

prenyltransferase; Reviewed


Pssm-ID: 183812  Cd Length: 279  Bit Score: 39.55  E-value: 2.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973   92 HHYARCYWELSKAKLSMLVVATSGTGYILGTGNAAISFPGLCYTCAgtMMIAASANSLNQIFEISNDSKMKRTmlRPLPS 171
Cdd:PRK12884   1 RTKMKAYLELLRPEHGLMAGIAVVLGAIIALGGLPLDEALLGFLTA--FFASGSANALNDYFDYEVDRINRPD--RPIPS 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 21280973  172 GRISVPHAVAWATIAGASGACL--LASKTNMLAAGLASANLVLYA 214
Cdd:PRK12884  77 GRISRREALLLAILLFILGLIAayLISPLAFLVVILVSVLGILYN 121
PLN02809 PLN02809
4-hydroxybenzoate nonaprenyltransferase
 136-290 7.86e-03

4-hydroxybenzoate nonaprenyltransferase


Pssm-ID: 178405  Cd Length: 289  Bit Score: 38.13  E-value: 7.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973  136 CAGTMMIAASANSLNQIFEISNDSKMKRTMLRPLPSGRISVPHAVAWATIAGASGACLLASKTNM-LAAGLASANLVlya 214
Cdd:PLN02809  51 GCGALLLRGAGCTINDLLDRDIDKKVERTKLRPIASGALTPFQGVGFLGAQLLLGLGILLQLNNYsRILGASSLLLV--- 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21280973  215 FVYTPLKQLHPintWVGAVVGAI---PPLLGWAAASGQISYnSMILP--AALYFWQIPHFMALAHLCRNDYAAGGYKMLS 289
Cdd:PLN02809 128 FTYPLMKRFTF---WPQAFLGLTfnwGALLGWAAVKGSLDP-AVVLPlyASGVCWTLVYDTIYAHQDKEDDLKVGVKSTA 203


                 .
gi 21280973  290 L 290
Cdd:PLN02809 204 L 204
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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