NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|18175627|gb|AAL59899|]
View 

unknown protein [Arabidopsis thaliana]

Protein Classification

ATP-binding protein( domain architecture ID 16031656)

ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain may function as an ATPase, similar to Arabidopsis thaliana BCS1-like protein

CATH:  3.40.50.300
EC:  3.6.1.-
Gene Ontology:  GO:0005524|GO:0016887
PubMed:  15037234|18466635|16689629
SCOP:  4003976

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 218-391 1.76e-68

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


:

Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 216.45  E-value: 1.76e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 218 IKSDLIKFSKSKDYYKKIGKAWKRGYLLFGPPGTGKSTMIAAMANFLEYDVYDLELTTVKDNTHLRRLLIETSAK-SIIV 296
Cdd:cd19510   1 IIDDLKDFIKNEDWYNDRGIPYRRGYLLYGPPGTGKSSFIAALAGELDYDICDLNLSEVVLTDDRLNHLLNTAPKqSIIL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 297 IEDIDCSLNLTGQRkkkeeeeedgddkntiekkmMMKNEGENKESKVTLSGLLNFIDGLWSacGGERIIVFTTNFVDKLD 376
Cdd:cd19510  81 LEDIDAAFESREHN--------------------KKNPSAYGGLSRVTFSGLLNALDGVAS--SEERIVFMTTNHIERLD 138

                       170
                ....*....|....*
gi 18175627 377 PALIRKGRMDKHIEM 391
Cdd:cd19510 139 PALIRPGRVDMKIYM 153
AAA_assoc pfam14363
Domain associated at C-terminal with AAA; This domain is found in association with the AAA ...
 39-123 1.25e-29

Domain associated at C-terminal with AAA; This domain is found in association with the AAA family, pfam00004.


:

Pssm-ID: 464152  Cd Length: 95  Bit Score: 111.49  E-value: 1.25e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627    39 FLYRLFGRFYPYIQITFHEYSGehFKRSEAYLGIQSYLSKDSSAR-AKKLKANTTKGSKSIVLSMDDKEEITDDFEGIRV 117
Cdd:pfam14363  12 KLARLFSRFSPYLTIVIDEFDG--FSRNELYDAAQTYLSTKISPSsARRLKASKSPKSKSLVLSLDDNEEVTDVFEGVKL 89


                  ....*.
gi 18175627   118 WWQSKK 123
Cdd:pfam14363  90 WWTLVV 95
 
Name Accession Description Interval E-value
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 218-391 1.76e-68

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 216.45  E-value: 1.76e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 218 IKSDLIKFSKSKDYYKKIGKAWKRGYLLFGPPGTGKSTMIAAMANFLEYDVYDLELTTVKDNTHLRRLLIETSAK-SIIV 296
Cdd:cd19510   1 IIDDLKDFIKNEDWYNDRGIPYRRGYLLYGPPGTGKSSFIAALAGELDYDICDLNLSEVVLTDDRLNHLLNTAPKqSIIL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 297 IEDIDCSLNLTGQRkkkeeeeedgddkntiekkmMMKNEGENKESKVTLSGLLNFIDGLWSacGGERIIVFTTNFVDKLD 376
Cdd:cd19510  81 LEDIDAAFESREHN--------------------KKNPSAYGGLSRVTFSGLLNALDGVAS--SEERIVFMTTNHIERLD 138

                       170
                ....*....|....*
gi 18175627 377 PALIRKGRMDKHIEM 391
Cdd:cd19510 139 PALIRPGRVDMKIYM 153
AAA_assoc pfam14363
Domain associated at C-terminal with AAA; This domain is found in association with the AAA ...
 39-123 1.25e-29

Domain associated at C-terminal with AAA; This domain is found in association with the AAA family, pfam00004.


Pssm-ID: 464152  Cd Length: 95  Bit Score: 111.49  E-value: 1.25e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627    39 FLYRLFGRFYPYIQITFHEYSGehFKRSEAYLGIQSYLSKDSSAR-AKKLKANTTKGSKSIVLSMDDKEEITDDFEGIRV 117
Cdd:pfam14363  12 KLARLFSRFSPYLTIVIDEFDG--FSRNELYDAAQTYLSTKISPSsARRLKASKSPKSKSLVLSLDDNEEVTDVFEGVKL 89


                  ....*.
gi 18175627   118 WWQSKK 123
Cdd:pfam14363  90 WWTLVV 95
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 243-393 1.36e-18

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 81.87  E-value: 1.36e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627   243 YLLFGPPGTGKSTMIAAMAN-----FLEYDVYDLELTTVKDNTHLRRLLIE---TSAKSIIVIEDIDCslnLTGQRkkke 314
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKelgapFIEISGSELVSKYVGESEKRLRELFEaakKLAPCVIFIDEIDA---LAGSR---- 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 18175627   315 eeeedgddkntiekkmmmkNEGENKESKVTLSGLLNFIDGLwSACGGERIIVFTTNFVDKLDPALIrkGRMDKHIEMSY 393
Cdd:pfam00004  74 -------------------GSGGDSESRRVVNQLLTELDGF-TSSNSKVIVIAATNRPDKLDPALL--GRFDRIIEFPL 130
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 197-390 2.13e-17

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 83.13  E-value: 2.13e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 197 VTFEHPA-TFDTLAMEENKKEEIKSDLIKFSKSKDYYKKIGKAWKRGYLLFGPPGTGKsTMIA-AMANFLEYDVYDLELT 274
Cdd:COG1222  68 VPAESPDvTFDDIGGLDEQIEEIREAVELPLKNPELFRKYGIEPPKGVLLYGPPGTGK-TLLAkAVAGELGAPFIRVRGS 146

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 275 TVKD--------NthLRRL--LIETSAKSIIVIEDIDcslnltgqrkkkeeeeedgddknTIEKKMMmkNEGENKESKVT 344
Cdd:COG1222 147 ELVSkyigegarN--VREVfeLAREKAPSIIFIDEID-----------------------AIAARRT--DDGTSGEVQRT 199

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 18175627 345 LSGLLNFIDGlWSACGGERIIVfTTNFVDKLDPALIRKGRMDKHIE 390
Cdd:COG1222 200 VNQLLAELDG-FESRGDVLIIA-ATNRPDLLDPALLRPGRFDRVIE 243
ftsH CHL00176
cell division protein; Validated
 180-405 6.87e-13

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 70.85  E-value: 6.87e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627  180 YSNTPGQSHGNNSKwSHVTFEHPA----TFDTLA-MEENKKE--EIKSdlikFSKSKDYYKKIGKAWKRGYLLFGPPGTG 252
Cdd:CHL00176 154 FKGGPGQNLMNFGK-SKARFQMEAdtgiTFRDIAgIEEAKEEfeEVVS----FLKKPERFTAVGAKIPKGVLLVGPPGTG 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627  253 KSTMIAAMANFLEYDVYDLELTTVKD------NTHLRRLL--IETSAKSIIVIEDIDcslnltgqrkkkeeeeedgddkn 324
Cdd:CHL00176 229 KTLLAKAIAGEAEVPFFSISGSEFVEmfvgvgAARVRDLFkkAKENSPCIVFIDEID----------------------- 285

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627  325 TIEKKMMMKNEGENKESKVTLSGLLNFIDGLWSACGgeRIIVFTTNFVDKLDPALIRKGRMDKHIEMSYCCFEA----FK 400
Cdd:CHL00176 286 AVGRQRGAGIGGGNDEREQTLNQLLTEMDGFKGNKG--VIVIAATNRVDILDAALLRPGRFDRQITVSLPDREGrldiLK 363


                 ....*
gi 18175627  401 VLAKN 405
Cdd:CHL00176 364 VHARN 368
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 215-455 2.38e-10

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 63.00  E-value: 2.38e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627   215 KEEIKS--DLIKFS-KSKDYYKKIGKAWKRGYLLFGPPGTGKSTMIAAMANFLEYDVYDLELTTV------KDNTHLRRL 285
Cdd:TIGR01243 184 KEAKEKirEMVELPmKHPELFEHLGIEPPKGVLLYGPPGTGKTLLAKAVANEAGAYFISINGPEImskyygESEERLREI 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627   286 L--IETSAKSIIVIEDIDcslnltgqrkkkeeeeedgddknTIEKKmmmKNEGENKESKVTLSGLLNFIDGLWSAcgGER 363
Cdd:TIGR01243 264 FkeAEENAPSIIFIDEID-----------------------AIAPK---REEVTGEVEKRVVAQLLTLMDGLKGR--GRV 315

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627   364 IIVFTTNFVDKLDPALIRKGRMDKHIEMSYCCFEAfkvlAKNYLDVEESEMFEEIKRLLEvEEIKMTPADVGENLLPKSe 443
Cdd:TIGR01243 316 IVIGATNRPDALDPALRRPGRFDREIVIRVPDKRA----RKEILKVHTRNMPLAEDVDLD-KLAEVTHGFVGADLAALA- 389

                         250
                  ....*....|..
gi 18175627   444 KEGGETCLKRLI 455
Cdd:TIGR01243 390 KEAAMAALRRFI 401
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 240-270 6.26e-04

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 40.43  E-value: 6.26e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 18175627    240 KRGYLLFGPPGTGKSTMIAAMANFLEYDVYD 270
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPPGGG 32
 
Name Accession Description Interval E-value
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 218-391 1.76e-68

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 216.45  E-value: 1.76e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 218 IKSDLIKFSKSKDYYKKIGKAWKRGYLLFGPPGTGKSTMIAAMANFLEYDVYDLELTTVKDNTHLRRLLIETSAK-SIIV 296
Cdd:cd19510   1 IIDDLKDFIKNEDWYNDRGIPYRRGYLLYGPPGTGKSSFIAALAGELDYDICDLNLSEVVLTDDRLNHLLNTAPKqSIIL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 297 IEDIDCSLNLTGQRkkkeeeeedgddkntiekkmMMKNEGENKESKVTLSGLLNFIDGLWSacGGERIIVFTTNFVDKLD 376
Cdd:cd19510  81 LEDIDAAFESREHN--------------------KKNPSAYGGLSRVTFSGLLNALDGVAS--SEERIVFMTTNHIERLD 138

                       170
                ....*....|....*
gi 18175627 377 PALIRKGRMDKHIEM 391
Cdd:cd19510 139 PALIRPGRVDMKIYM 153
AAA_assoc pfam14363
Domain associated at C-terminal with AAA; This domain is found in association with the AAA ...
 39-123 1.25e-29

Domain associated at C-terminal with AAA; This domain is found in association with the AAA family, pfam00004.


Pssm-ID: 464152  Cd Length: 95  Bit Score: 111.49  E-value: 1.25e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627    39 FLYRLFGRFYPYIQITFHEYSGehFKRSEAYLGIQSYLSKDSSAR-AKKLKANTTKGSKSIVLSMDDKEEITDDFEGIRV 117
Cdd:pfam14363  12 KLARLFSRFSPYLTIVIDEFDG--FSRNELYDAAQTYLSTKISPSsARRLKASKSPKSKSLVLSLDDNEEVTDVFEGVKL 89


                  ....*.
gi 18175627   118 WWQSKK 123
Cdd:pfam14363  90 WWTLVV 95
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 215-390 2.59e-21

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 90.42  E-value: 2.59e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 215 KEEIKsDLIKFSKSKDYYKKIGKAWKRGYLLFGPPGTGKSTMIAAMANFLEYDVYDLELTTVKDN------THLRRL--L 286
Cdd:cd19481   2 KASLR-EAVEAPRRGSRLRRYGLGLPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKyvgeseKNLRKIfeR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 287 IETSAKSIIVIEDIDcslNLTGQRKkkeeeeedgddkntiekkmmmkNEGENKESKVTLSGLLNFIDGLwsaCGGERIIV 366
Cdd:cd19481  81 ARRLAPCILFIDEID---AIGRKRD----------------------SSGESGELRRVLNQLLTELDGV---NSRSKVLV 132

                       170       180
                ....*....|....*....|....*
gi 18175627 367 F-TTNFVDKLDPALIRKGRMDKHIE 390
Cdd:cd19481 133 IaATNRPDLLDPALLRPGRFDEVIE 157
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 243-393 1.36e-18

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 81.87  E-value: 1.36e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627   243 YLLFGPPGTGKSTMIAAMAN-----FLEYDVYDLELTTVKDNTHLRRLLIE---TSAKSIIVIEDIDCslnLTGQRkkke 314
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKelgapFIEISGSELVSKYVGESEKRLRELFEaakKLAPCVIFIDEIDA---LAGSR---- 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 18175627   315 eeeedgddkntiekkmmmkNEGENKESKVTLSGLLNFIDGLwSACGGERIIVFTTNFVDKLDPALIrkGRMDKHIEMSY 393
Cdd:pfam00004  74 -------------------GSGGDSESRRVVNQLLTELDGF-TSSNSKVIVIAATNRPDKLDPALL--GRFDRIIEFPL 130
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 197-390 2.13e-17

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 83.13  E-value: 2.13e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 197 VTFEHPA-TFDTLAMEENKKEEIKSDLIKFSKSKDYYKKIGKAWKRGYLLFGPPGTGKsTMIA-AMANFLEYDVYDLELT 274
Cdd:COG1222  68 VPAESPDvTFDDIGGLDEQIEEIREAVELPLKNPELFRKYGIEPPKGVLLYGPPGTGK-TLLAkAVAGELGAPFIRVRGS 146

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 275 TVKD--------NthLRRL--LIETSAKSIIVIEDIDcslnltgqrkkkeeeeedgddknTIEKKMMmkNEGENKESKVT 344
Cdd:COG1222 147 ELVSkyigegarN--VREVfeLAREKAPSIIFIDEID-----------------------AIAARRT--DDGTSGEVQRT 199

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 18175627 345 LSGLLNFIDGlWSACGGERIIVfTTNFVDKLDPALIRKGRMDKHIE 390
Cdd:COG1222 200 VNQLLAELDG-FESRGDVLIIA-ATNRPDLLDPALLRPGRFDRVIE 243
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
 204-389 1.48e-16

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 77.27  E-value: 1.48e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 204 TFDTLAMEENKKEEIKsDLIKFSKSKDYYKKIGKAWKRGYLLFGPPGTGKsTMIA-AMAN-------------FLEY--- 266
Cdd:cd19501   2 TFKDVAGCEEAKEELK-EVVEFLKNPEKFTKLGAKIPKGVLLVGPPGTGK-TLLAkAVAGeagvpffsisgsdFVEMfvg 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 267 ----DVYDLeLTTVKDNthlrrllietsAKSIIVIEDIDcslnltgqrkkkeeeeedgddknTIEKKMMMKNEGENKESK 342
Cdd:cd19501  80 vgasRVRDL-FEQAKKN-----------APCIVFIDEID-----------------------AVGRKRGAGLGGGHDERE 124

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 18175627 343 VTLSGLLNFIDGLWSACGgerIIVF-TTNFVDKLDPALIRKGRMDKHI 389
Cdd:cd19501 125 QTLNQLLVEMDGFESNTG---VIVIaATNRPDVLDPALLRPGRFDRQV 169
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 205-390 4.78e-16

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 79.96  E-value: 4.78e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 205 FDTLAMEENKKEEIKSDLIKFSKSKDYYKKIGKAWKRGYLLFGPPGTGKSTMIAAMANFLEYDVYDLELTTVKD----NT 280
Cdd:COG0464 156 LDDLGGLEEVKEELRELVALPLKRPELREEYGLPPPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLVSkyvgET 235

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 281 --HLRRLL--IETSAKSIIVIEDIDcslNLTGQRkkkeeeeedgddkntiekkmmmkNEGENKESKVTLSGLLNFIDGLw 356
Cdd:COG0464 236 ekNLREVFdkARGLAPCVLFIDEAD---ALAGKR-----------------------GEVGDGVGRRVVNTLLTEMEEL- 288

                       170       180       190
                ....*....|....*....|....*....|....
gi 18175627 357 sacGGERIIVFTTNFVDKLDPALIRkgRMDKHIE 390
Cdd:COG0464 289 ---RSDVVVIAATNRPDLLDPALLR--RFDEIIF 317
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 212-390 4.39e-15

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 73.14  E-value: 4.39e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 212 ENKKEEIKSDLIKFSKSKDYYKKIGKAWKRGYLLFGPPGTGKSTMIAAMAN-----FLEYDVYDLELTTVKDNTHLRRLL 286
Cdd:cd19502   9 DEQIREIREVVELPLKHPELFEELGIEPPKGVLLYGPPGTGKTLLAKAVANhtdatFIRVVGSELVQKYIGEGARLVREL 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 287 IE---TSAKSIIVIEDIDcslnltgqrkkkeeeeedgddknTIEKKMMMKNEGENKESKVTLSGLLNFIDGlWSACGGER 363
Cdd:cd19502  89 FEmarEKAPSIIFIDEID-----------------------AIGAKRFDSGTGGDREVQRTMLELLNQLDG-FDPRGNIK 144

                       170       180
                ....*....|....*....|....*..
gi 18175627 364 IIvFTTNFVDKLDPALIRKGRMDKHIE 390
Cdd:cd19502 145 VI-MATNRPDILDPALLRPGRFDRKIE 170
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 232-390 7.62e-14

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 69.24  E-value: 7.62e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 232 YKKIGKAWKRGYLLFGPPGTGKSTMIAAMANFLEYDVYDLELTTV------KDNTHLRRLLIETS--AKSIIVIEDIDcs 303
Cdd:cd19503  26 FRALGLKPPRGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIvskylgESEKNLREIFEEARshAPSIIFIDEID-- 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 304 lNLTGQRkkkeeeeedgddkntiekkmmmKNEGENKESKVtLSGLLNFIDGLWSAcgGERIIVFTTNFVDKLDPALIRKG 383
Cdd:cd19503 104 -ALAPKR----------------------EEDQREVERRV-VAQLLTLMDGMSSR--GKVVVIAATNRPDAIDPALRRPG 157


                ....*..
gi 18175627 384 RMDKHIE 390
Cdd:cd19503 158 RFDREVE 164
ftsH CHL00176
cell division protein; Validated
 180-405 6.87e-13

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 70.85  E-value: 6.87e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627  180 YSNTPGQSHGNNSKwSHVTFEHPA----TFDTLA-MEENKKE--EIKSdlikFSKSKDYYKKIGKAWKRGYLLFGPPGTG 252
Cdd:CHL00176 154 FKGGPGQNLMNFGK-SKARFQMEAdtgiTFRDIAgIEEAKEEfeEVVS----FLKKPERFTAVGAKIPKGVLLVGPPGTG 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627  253 KSTMIAAMANFLEYDVYDLELTTVKD------NTHLRRLL--IETSAKSIIVIEDIDcslnltgqrkkkeeeeedgddkn 324
Cdd:CHL00176 229 KTLLAKAIAGEAEVPFFSISGSEFVEmfvgvgAARVRDLFkkAKENSPCIVFIDEID----------------------- 285

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627  325 TIEKKMMMKNEGENKESKVTLSGLLNFIDGLWSACGgeRIIVFTTNFVDKLDPALIRKGRMDKHIEMSYCCFEA----FK 400
Cdd:CHL00176 286 AVGRQRGAGIGGGNDEREQTLNQLLTEMDGFKGNKG--VIVIAATNRVDILDAALLRPGRFDRQITVSLPDREGrldiLK 363


                 ....*
gi 18175627  401 VLAKN 405
Cdd:CHL00176 364 VHARN 368
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 212-391 2.04e-12

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 69.03  E-value: 2.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627  212 ENKKEEIKsDLIKFSKSK-DYYKKIGKAWKRGYLLFGPPGTGKSTMIAAMAN-----FLEYDVYDLELTTVKDNTHLRRL 285
Cdd:PTZ00361 189 EQQIQEIK-EAVELPLTHpELYDDIGIKPPKGVILYGPPGTGKTLLAKAVANetsatFLRVVGSELIQKYLGDGPKLVRE 267

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627  286 LI---ETSAKSIIVIEDIDcslnltgqrkkkeeeeedgddknTIEKKMMMKNEGENKESKVTLSGLLNFIDGlWSACGGE 362
Cdd:PTZ00361 268 LFrvaEENAPSIVFIDEID-----------------------AIGTKRYDATSGGEKEIQRTMLELLNQLDG-FDSRGDV 323

                        170       180
                 ....*....|....*....|....*....
gi 18175627  363 RIIVfTTNFVDKLDPALIRKGRMDKHIEM 391
Cdd:PTZ00361 324 KVIM-ATNRIESLDPALIRPGRIDRKIEF 351
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 215-389 3.86e-12

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 64.23  E-value: 3.86e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 215 KEEIKSDLIKFSKSKDYYKKIGKAWKRGYLLFGPPGTGKSTMIAAMA-----NFLEYDVYDLELTTVKDNTHLRRLLIET 289
Cdd:cd19511   2 KRELKEAVEWPLKHPDAFKRLGIRPPKGVLLYGPPGCGKTLLAKALAseaglNFISVKGPELFSKYVGESERAVREIFQK 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 290 ---SAKSIIVIEDIDcslNLTGQRkkkeeeeedgddkntiekkmmmkneGENKESKVT---LSGLLNFIDGLWSACGgeR 363
Cdd:cd19511  82 arqAAPCIIFFDEID---SLAPRR-------------------------GQSDSSGVTdrvVSQLLTELDGIESLKG--V 131

                       170       180
                ....*....|....*....|....*.
gi 18175627 364 IIVFTTNFVDKLDPALIRKGRMDKHI 389
Cdd:cd19511 132 VVIAATNRPDMIDPALLRPGRLDKLI 157
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 215-389 5.11e-11

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 60.97  E-value: 5.11e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 215 KEEIKSDLIKFSKSKDYYKKIGKAWKRGYLLFGPPGTGKSTMIAAM-----ANFLEydVYDLELTTV---KDNTHLRRLL 286
Cdd:cd19529   2 KQELKEAVEWPLLKPEVFKRLGIRPPKGILLYGPPGTGKTLLAKAVatesnANFIS--VKGPELLSKwvgESEKAIREIF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 287 IET--SAKSIIVIEDIDcslNLTGQRkkkeeeeedgddkntiekkmmmkneGENKESKVT---LSGLLNFIDGLWSAcgG 361
Cdd:cd19529  80 RKArqVAPCVIFFDEID---SIAPRR-------------------------GTTGDSGVTervVNQLLTELDGLEEM--N 129

                       170       180
                ....*....|....*....|....*...
gi 18175627 362 ERIIVFTTNFVDKLDPALIRKGRMDKHI 389
Cdd:cd19529 130 GVVVIAATNRPDIIDPALLRAGRFDRLI 157
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
205-423 9.07e-11

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 62.21  E-value: 9.07e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 205 FDTLAMEENKKEEIKsDLIKFSKSKDYYKKIGKAWKRGYLLFGPPGTGKSTMIAAMANFLEYDVYDLELTTV------KD 278
Cdd:COG1223   1 LDDVVGQEEAKKKLK-LIIKELRRRENLRKFGLWPPRKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSLigsylgET 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 279 NTHLRRLLIET-SAKSIIVIEDIDcslnltgqrkkkeeeeedgddknTIEKKMMMKNegENKESKVTLSGLLNFIDGLws 357
Cdd:COG1223  80 ARNLRKLFDFArRAPCVIFFDEFD-----------------------AIAKDRGDQN--DVGEVKRVVNALLQELDGL-- 132

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 18175627 358 acGGERIIVFTTNFVDKLDPALIRkgRMDKHIEMSYCCFEAFKVLAKNYLDVEESEMFEEIKRLLE 423
Cdd:COG1223 133 --PSGSVVIAATNHPELLDSALWR--RFDEVIEFPLPDKEERKEILELNLKKFPLPFELDLKKLAK 194
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 217-389 1.82e-10

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 59.73  E-value: 1.82e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 217 EIKSDLIKFSKSKDYYKKIGKAWKRGYLLFGPPGTGKsTMIA-AMANFLEYDVYDLELTTV------KDNTHLRRLLIE- 288
Cdd:cd19518  11 ELCELLIHPILPPEYFQHLGVEPPRGVLLHGPPGCGK-TMLAnAIAGELKVPFLKISATEIvsgvsgESEEKIRELFDQa 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 289 -TSAKSIIVIEDIDCslnLTGQRkkkeeeeedgddkNTIEKKMmmknegenkESKVtLSGLLNFIDGL--WSACGGERII 365
Cdd:cd19518  90 iSNAPCIVFIDEIDA---ITPKR-------------ESAQREM---------ERRI-VSQLLTCMDELnnEKTAGGPVLV 143

                       170       180
                ....*....|....*....|....
gi 18175627 366 VFTTNFVDKLDPALIRKGRMDKHI 389
Cdd:cd19518 144 IGATNRPDSLDPALRRAGRFDREI 167
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
204-389 2.24e-10

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 63.13  E-value: 2.24e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627  204 TFDTLAMEENKKEEIkSDLIKFSKSKDYYKKIGKAWKRGYLLFGPPGTGKSTMIAAMAN-----FLEYDVYDLELTTVKD 278
Cdd:PRK10733 150 TFADVAGCDEAKEEV-AELVEYLREPSRFQKLGGKIPKGVLMVGPPGTGKTLLAKAIAGeakvpFFTISGSDFVEMFVGV 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627  279 NTHLRRLLIETSAKS---IIVIEDIDcslnltgqrkkkeeeeedgddknTIEKKMMMKNEGENKESKVTLSGLLNFIDGL 355
Cdd:PRK10733 229 GASRVRDMFEQAKKAapcIIFIDEID-----------------------AVGRQRGAGLGGGHDEREQTLNQMLVEMDGF 285

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 18175627  356 WsacGGERIIVF-TTNFVDKLDPALIRKGRMDKHI 389
Cdd:PRK10733 286 E---GNEGIIVIaATNRPDVLDPALLRPGRFDRQV 317
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 232-391 2.37e-10

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 59.37  E-value: 2.37e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 232 YKKIGKAWKRGYLLFGPPGTGKSTMIAAMANflEYDVYDLELT--------TVKDNTHLRRLLIETS--AKSIIVIEDID 301
Cdd:cd19519  26 FKAIGIKPPRGILLYGPPGTGKTLIARAVAN--ETGAFFFLINgpeimsklAGESESNLRKAFEEAEknAPAIIFIDEID 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 302 cslnltgqrkkkeeeeedgddknTIEKKmmmKNEGENKESKVTLSGLLNFIDGLWSAcgGERIIVFTTNFVDKLDPALIR 381
Cdd:cd19519 104 -----------------------AIAPK---REKTHGEVERRIVSQLLTLMDGLKQR--AHVIVMAATNRPNSIDPALRR 155

                       170
                ....*....|
gi 18175627 382 KGRMDKHIEM 391
Cdd:cd19519 156 FGRFDREIDI 165
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 215-455 2.38e-10

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 63.00  E-value: 2.38e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627   215 KEEIKS--DLIKFS-KSKDYYKKIGKAWKRGYLLFGPPGTGKSTMIAAMANFLEYDVYDLELTTV------KDNTHLRRL 285
Cdd:TIGR01243 184 KEAKEKirEMVELPmKHPELFEHLGIEPPKGVLLYGPPGTGKTLLAKAVANEAGAYFISINGPEImskyygESEERLREI 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627   286 L--IETSAKSIIVIEDIDcslnltgqrkkkeeeeedgddknTIEKKmmmKNEGENKESKVTLSGLLNFIDGLWSAcgGER 363
Cdd:TIGR01243 264 FkeAEENAPSIIFIDEID-----------------------AIAPK---REEVTGEVEKRVVAQLLTLMDGLKGR--GRV 315

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627   364 IIVFTTNFVDKLDPALIRKGRMDKHIEMSYCCFEAfkvlAKNYLDVEESEMFEEIKRLLEvEEIKMTPADVGENLLPKSe 443
Cdd:TIGR01243 316 IVIGATNRPDALDPALRRPGRFDREIVIRVPDKRA----RKEILKVHTRNMPLAEDVDLD-KLAEVTHGFVGADLAALA- 389

                         250
                  ....*....|..
gi 18175627   444 KEGGETCLKRLI 455
Cdd:TIGR01243 390 KEAAMAALRRFI 401
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
 232-393 6.86e-10

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 60.93  E-value: 6.86e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627  232 YKKIGKAWKRGYLLFGPPGTGKSTMIAAMAN-----FLEydVYDLELTT---------VKDNTHLRRllieTSAKSIIVI 297
Cdd:PTZ00454 171 YEQIGIDPPRGVLLYGPPGTGKTMLAKAVAHhttatFIR--VVGSEFVQkylgegprmVRDVFRLAR----ENAPSIIFI 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627  298 EDIDcslnltgqrkkkeeeeedgddknTIEKKMMMKNEGENKESKVTLSGLLNFIDGLWSACGGERIIvfTTNFVDKLDP 377
Cdd:PTZ00454 245 DEVD-----------------------SIATKRFDAQTGADREVQRILLELLNQMDGFDQTTNVKVIM--ATNRADTLDP 299

                        170
                 ....*....|....*.
gi 18175627  378 ALIRKGRMDKHIEMSY 393
Cdd:PTZ00454 300 ALLRPGRLDRKIEFPL 315
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 212-389 1.18e-09

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 56.98  E-value: 1.18e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 212 ENKKEEIKSDLIKFSKSKDYYKKIGKAWkRGYLLFGPPGTGKSTMIAAMAN-----FLEYDVYDLELTTVKDNTHLRRLL 286
Cdd:cd19509   5 DDAKEALKEAVILPSLRPDLFPGLRGPP-RGILLYGPPGTGKTLLARAVASesgstFFSISASSLVSKWVGESEKIVRAL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 287 IETSAK---SIIVIEDIDcslNLTGQRKkkeeeeedgddkntiekkmmmknEGENKESKVTLSGLLNFIDGLWSACGGER 363
Cdd:cd19509  84 FALARElqpSIIFIDEID---SLLSERG-----------------------SGEHEASRRVKTEFLVQMDGVLNKPEDRV 137

                       170       180
                ....*....|....*....|....*.
gi 18175627 364 IIVFTTNFVDKLDPALIRkgRMDKHI 389
Cdd:cd19509 138 LVLGATNRPWELDEAFLR--RFEKRI 161
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
 230-389 1.43e-09

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 57.30  E-value: 1.43e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 230 DYYKKIGKAWKrGYLLFGPPGTGKSTMIAAMANFLEYDVYDLELTTVKDNTH-----LRRLLIETS---AKSIIVIEDID 301
Cdd:cd19522  24 EFFKGIRRPWK-GVLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTSKYRgesekLVRLLFEMArfyAPTTIFIDEID 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 302 CSLNLTGqrkkkeeeeedgddkntiekkmmmkNEGENKESKVTLSGLLNFIDGLWSACGGER-----IIVFTTNFVDKLD 376
Cdd:cd19522 103 SICSRRG-------------------------TSEEHEASRRVKSELLVQMDGVGGASENDDpskmvMVLAATNFPWDID 157

                       170
                ....*....|...
gi 18175627 377 PALIRkgRMDKHI 389
Cdd:cd19522 158 EALRR--RLEKRI 168
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 212-423 2.63e-08

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 56.45  E-value: 2.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627   212 ENKKEEIKSDLIKFSKSKDYYKKIGKAWKRGYLLFGPPGTGKSTMIAAM-----ANFLEYDVYDLELTTVKDNTHLRRLL 286
Cdd:TIGR01243 459 EEVKQELREAVEWPLKHPEIFEKMGIRPPKGVLLFGPPGTGKTLLAKAVatesgANFIAVRGPEILSKWVGESEKAIREI 538

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627   287 IE---TSAKSIIVIEDIDCslnltgqrkkkeeeeedgddkntiekkmMMKNEGENKESKVT---LSGLLNFIDGLWSACG 360
Cdd:TIGR01243 539 FRkarQAAPAIIFFDEIDA----------------------------IAPARGARFDTSVTdriVNQLLTEMDGIQELSN 590

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18175627   361 geRIIVFTTNFVDKLDPALIRKGRMDKHIEM----SYCCFEAFKVLAKNyLDVEESEMFEEIKRLLE 423
Cdd:TIGR01243 591 --VVVIAATNRPDILDPALLRPGRFDRLILVpppdEEARKEIFKIHTRS-MPLAEDVDLEELAEMTE 654
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 215-389 6.43e-08

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 52.13  E-value: 6.43e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 215 KEEIKSDLIKFSKSKDYYKKIGKAWKRGYLLFGPPGTGKSTMIAAM-----ANFLEydVYDLELTTV---KDNTHLRRLL 286
Cdd:cd19528   2 KRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIanecqANFIS--VKGPELLTMwfgESEANVRDIF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 287 --IETSAKSIIVIEDIDcslnltgqrkkkeeeeedgddknTIEKKMMMKNEGENKESKVTLSGLLNFIDGLWSAcgGERI 364
Cdd:cd19528  80 dkARAAAPCVLFFDELD-----------------------SIAKARGGNIGDAGGAADRVINQILTEMDGMNTK--KNVF 134

                       170       180
                ....*....|....*....|....*
gi 18175627 365 IVFTTNFVDKLDPALIRKGRMDKHI 389
Cdd:cd19528 135 IIGATNRPDIIDPAILRPGRLDQLI 159
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 240-393 3.41e-07

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 49.84  E-value: 3.41e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 240 KRGYLLFGPPGTGKSTMIAAMANFLEYDVYDL------ELTTVKD--------NTHLRRLLIETSAKSIIVIEDIDcsln 305
Cdd:cd00009  19 PKNLLLYGPPGTGKTTLARAIANELFRPGAPFlylnasDLLEGLVvaelfghfLVRLLFELAEKAKPGVLFIDEID---- 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 306 ltgqrkkkeeeeedgddkntiekkmmmknegenKESKVTLSGLLNFIDGL--WSACGGERIIVFTTNFVDKLDPALIRKG 383
Cdd:cd00009  95 ---------------------------------SLSRGAQNALLRVLETLndLRIDRENVRVIGATNRPLLGDLDRALYD 141

                       170
                ....*....|
gi 18175627 384 RMDKHIEMSY 393
Cdd:cd00009 142 RLDIRIVIPL 151
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
 241-387 4.81e-07

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 49.82  E-value: 4.81e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 241 RGYLLFGPPGTGKSTMIAAMAN----------FLEYDVYDLELTTVKDNTHLRRLLIETSAK---SIIVIEDIDcslNLT 307
Cdd:cd19517  35 RGVLFHGPPGTGKTLMARALAAecskggqkvsFFMRKGADCLSKWVGEAERQLRLLFEEAYRmqpSIIFFDEID---GLA 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 308 GQRkkkeeeeedgddkntiekkmmmKNEGENKESKVtLSGLLNFIDGLWSAcgGERIIVFTTNFVDKLDPALIRKGRMDK 387
Cdd:cd19517 112 PVR----------------------SSKQEQIHASI-VSTLLALMDGLDNR--GQVVVIGATNRPDALDPALRRPGRFDR 166
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 232-390 8.82e-07

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 50.99  E-value: 8.82e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627  232 YKKIGKAWKRGYLLFGPPGTGKsTMIA-AMAN-----FLEydVYDLELttVK----DNTHLRRLLIETSAK---SIIVIE 298
Cdd:PRK03992 157 FEEVGIEPPKGVLLYGPPGTGK-TLLAkAVAHetnatFIR--VVGSEL--VQkfigEGARLVRELFELAREkapSIIFID 231

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627  299 DIDcslnltgqrkkkeeeeedgddknTI-EKKMMMKNEGEnKESKVTLSGLLNFIDGlWSACGGERIIVfTTNFVDKLDP 377
Cdd:PRK03992 232 EID-----------------------AIaAKRTDSGTSGD-REVQRTLMQLLAEMDG-FDPRGNVKIIA-ATNRIDILDP 285

                        170
                 ....*....|...
gi 18175627  378 ALIRKGRMDKHIE 390
Cdd:PRK03992 286 AILRPGRFDRIIE 298
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 212-387 1.32e-06

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 48.57  E-value: 1.32e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 212 ENKKEEIKSDLIKFSKSKDYYKKiGKAWK--RGYLLFGPPGTGKsTMIA------AMANFLEYDVYDLELTTVKDNTHLR 283
Cdd:cd19520   6 DEVITELKELVILPLQRPELFDN-SRLLQppKGVLLYGPPGCGK-TMLAkatakeAGARFINLQVSSLTDKWYGESQKLV 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 284 RLLIETSAK---SIIVIEDIDCSLnltGQRkkkeeeeedgdDKNTIEKKMMMKNEgenkeskvtlsgLLNFIDGLwSACG 360
Cdd:cd19520  84 AAVFSLASKlqpSIIFIDEIDSFL---RQR-----------SSTDHEATAMMKAE------------FMSLWDGL-STDG 136

                       170       180
                ....*....|....*....|....*...
gi 18175627 361 GERIIVF-TTNFVDKLDPALIRkgRMDK 387
Cdd:cd19520 137 NCRVIVMgATNRPQDLDEAILR--RMPK 162
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 215-387 2.16e-06

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 47.48  E-value: 2.16e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 215 KEEIKSDLIKFSKSKDYYKKIGKAWKRGYLLFGPPGTGKSTMIAAMA-----NFLEYDVYDLELTTVKDNTHLRRLLIE- 288
Cdd:cd19530   5 REELTMSILRPIKRPDIYKALGIDLPTGVLLYGPPGCGKTLLAKAVAnesgaNFISVKGPELLNKYVGESERAVRQVFQr 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 289 --TSAKSIIVIEDIDCslnLTGQRkkkeeeeedgddkntiekkmmmkNEGENKESKVTLSGLLNFIDGLwsacgGERIIV 366
Cdd:cd19530  85 arASAPCVIFFDEVDA---LVPKR-----------------------GDGGSWASERVVNQLLTEMDGL-----EERSNV 133

                       170       180
                ....*....|....*....|....
gi 18175627 367 F---TTNFVDKLDPALIRKGRMDK 387
Cdd:cd19530 134 FviaATNRPDIIDPAMLRPGRLDK 157
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 191-310 3.45e-06

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 47.16  E-value: 3.45e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 191 NSKWSHVtfehpatfdtlAMEENKKEEIKSDLIKFSKSKDYYKKIGKAWkRGYLLFGPPGTGKSTMIAAMA-----NFLE 265
Cdd:cd19521   3 NVKWEDV-----------AGLEGAKEALKEAVILPVKFPHLFTGNRKPW-SGILLYGPPGTGKSYLAKAVAteansTFFS 70

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 18175627 266 YDVYDLELTTVKDNTHLRRLLIE---TSAKSIIVIEDIDcslNLTGQR 310
Cdd:cd19521  71 VSSSDLVSKWMGESEKLVKQLFAmarENKPSIIFIDEVD---SLCGTR 115
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 237-382 4.55e-06

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 46.77  E-value: 4.55e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 237 KAWKRGYLLFGPPGTGKsTMIA------AMANFLEYDVYDLELTTVKDNTHLRRLLIETSAK---SIIVIEDIDcSLnlt 307
Cdd:cd19524  30 RAPARGLLLFGPPGNGK-TMLAkavaaeSNATFFNISAASLTSKYVGEGEKLVRALFAVARElqpSIIFIDEVD-SL--- 104

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 18175627 308 gqrkkkeeeeedgddkntiekkMMMKNEGENKESKVTLSGLLNFIDGLWSAcGGERIIVF-TTNFVDKLDPALIRK 382
Cdd:cd19524 105 ----------------------LSERSEGEHEASRRLKTEFLIEFDGVQSN-GDDRVLVMgATNRPQELDDAVLRR 157
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 240-387 4.18e-05

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 44.04  E-value: 4.18e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 240 KRGYLLFGPPGTGKSTMIAAMA-----NFLEydVYDLELTTV---KDNTHLRRLL--IETSAKSIIVIEDIDcslNLTGQ 309
Cdd:cd19527  26 RSGILLYGPPGTGKTLLAKAIAtecslNFLS--VKGPELINMyigESEANVREVFqkARDAKPCVIFFDELD---SLAPS 100

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18175627 310 RKkkeeeeedgddkNTIEKKMMMKNegenkeskvTLSGLLNFIDGLwSACGGERIIVFTTNFVDKLDPALIRKGRMDK 387
Cdd:cd19527 101 RG------------NSGDSGGVMDR---------VVSQLLAELDGM-SSSGQDVFVIGATNRPDLLDPALLRPGRFDK 156
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 187-382 6.56e-05

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 43.82  E-value: 6.56e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 187 SHGNNSKWSHVtfehpatfdtlAMEENKKEEIKSDLIKFSKSKDYYKKIgKAWKRGYLLFGPPGTGKsTMIA------AM 260
Cdd:cd19525  14 DHGPPINWADI-----------AGLEFAKKTIKEIVVWPMLRPDIFTGL-RGPPKGILLFGPPGTGK-TLIGkciasqSG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18175627 261 ANFLEYDVYDLELTTVKDNTHLRRLLIETS---AKSIIVIEDIDcslNLTGQRkkkeeeeedgddkntiekkmmmkNEGE 337
Cdd:cd19525  81 ATFFSISASSLTSKWVGEGEKMVRALFSVArckQPAVIFIDEID---SLLSQR-----------------------GEGE 134

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 18175627 338 NKESKVTLSGLLNFIDGLWSACGGERIIVFTTNFVDKLDPALIRK 382
Cdd:cd19525 135 HESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARRR 179
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 240-270 6.26e-04

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 40.43  E-value: 6.26e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 18175627    240 KRGYLLFGPPGTGKSTMIAAMANFLEYDVYD 270
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPPGGG 32
PRK04195 PRK04195
replication factor C large subunit; Provisional
 220-271 6.80e-04

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 42.22  E-value: 6.80e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 18175627  220 SDLIKFSKSKDYYKKIGKAWKRGY-----LLFGPPGTGKSTMIAAMANFLEYDVYDL 271
Cdd:PRK04195  14 SDVVGNEKAKEQLREWIESWLKGKpkkalLLYGPPGVGKTSLAHALANDYGWEVIEL 70
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
204-261 3.18e-03

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 40.02  E-value: 3.18e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 18175627 204 TFDTLAMEENKKEEIKsDLIKFSKSKDYYKKIGKAWKRGYLLFGPPGTGKsTMIA-AMA 261
Cdd:COG0465 140 TFDDVAGVDEAKEELQ-EIVDFLKDPEKFTRLGAKIPKGVLLVGPPGTGK-TLLAkAVA 196
PRK06851 PRK06851
hypothetical protein; Provisional
 231-272 4.16e-03

hypothetical protein; Provisional


Pssm-ID: 235878  Cd Length: 367  Bit Score: 39.56  E-value: 4.16e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 18175627  231 YYKKIGKAWKRGYLLFGPPGTGKSTMIAAMANFLEYDVYDLE 272
Cdd:PRK06851  21 LYDSIIDGANRIFILKGGPGTGKSTLMKKIGEEFLEKGYDVE 62
GPN2 cd17871
GPN-loop GTPase 2; GPN-loop GTPase 2 (GPN2) is a small GTPase required for proper localization ...
 242-265 5.08e-03

GPN-loop GTPase 2; GPN-loop GTPase 2 (GPN2) is a small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). It forms heterodimers with GPN1 or GPN3.


Pssm-ID: 349780  Cd Length: 196  Bit Score: 38.29  E-value: 5.08e-03
                        10        20
                ....*....|....*....|....
gi 18175627 242 GYLLFGPPGTGKSTMIAAMANFLE 265
Cdd:cd17871   2 GQVVIGPPGSGKTTYCKGMQQFLS 25
RecA-like_Pch2-like cd19508
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...
 205-264 5.10e-03

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion


Pssm-ID: 410916 [Multi-domain]  Cd Length: 199  Bit Score: 38.20  E-value: 5.10e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18175627 205 FDTLAMEENKKEEIKS---DLIKFSKSKDYYKKIgkAWKRGYLLFGPPGTGKSTMIAAMANFL 264
Cdd:cd19508  16 WESLIYDSNLKSRLLDyvtTTLLFSDKNVNTNLI--TWNRLVLLHGPPGTGKTSLCKALAQKL 76
DEXXQc_Upf1-like cd17934
DEXXQ-box helicase domain of Upf1-like helicase; The Upf1-like helicase family includes UPF1, ...
 244-264 9.61e-03

DEXXQ-box helicase domain of Upf1-like helicase; The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), coronavirus Nsp13, and similar proteins. They belong to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438708 [Multi-domain]  Cd Length: 121  Bit Score: 36.06  E-value: 9.61e-03
                        10        20
                ....*....|....*....|.
gi 18175627 244 LLFGPPGTGKSTMIAAMANFL 264
Cdd:cd17934   3 LIQGPPGTGKTTTIAAIVLQL 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH