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Conserved domains on  [gi|16768490|gb|AAL28464|]
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GM06077p [Drosophila melanogaster]

Protein Classification

protein HGH1( domain architecture ID 10513361)

protein HGH1 is an armadillo repeat protein that binds to the dynamic central domain III of eukaryotic elongation factor 2 (eEF2) via a bipartite interface; contains both DUF383 and DUF384 domains

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF383 pfam04063
Domain of unknown function (DUF383);
103-275 6.99e-60

Domain of unknown function (DUF383);


:

Pssm-ID: 461153  Cd Length: 188  Bit Score: 191.60  E-value: 6.99e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16768490   103 ITNEQSDLADPWSMVLSNLTRVESLVHEILD--------TLERDDHTLPRLAKAF---AQLDYNKKkAKLHYLAPIFCNL 171
Cdd:pfam04063   2 ITDPKSPLADLACMLLSNLTKSDSICKSLLElkrssepeDLSSSGLAIDQLVDLFvkgADGGYNKH-ANYDYLAYVFANL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16768490   172 TQVSRGREL----CCHRKYELLEKLLPFASFEgSVVRRGGTIGILKNVCFDTVYHDVILNEQS-SILVAILQPLCGPEEF 246
Cdd:pfam04063  81 SQLPEGRKYfltpQEYDGVVPLSKLLVFTEHD-SVIRRGGVASTIKNCCFDTEAHEWLLSEEEiDILPYLLLPLAGPEEY 159

                         170       180
                  ....*....|....*....|....*....
gi 16768490   247 SDEDNELLPIELQYLPESKTREEDPDLRK 275
Cdd:pfam04063 160 DEEDMEKLPPELQLLPPDKKREPDPDIRL 188
DUF384 pfam04064
Domain of unknown function (DUF384);
280-338 3.80e-21

Domain of unknown function (DUF384);


:

Pssm-ID: 461154  Cd Length: 55  Bit Score: 85.58  E-value: 3.80e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 16768490   280 CLLQLCSTRRSREILRSRGVYEILREYHKWEakvgKDSDCLLACENVVDILIKKEEEIG 338
Cdd:pfam04064   1 SLLLLCTTREGREYLRSKGVYPILRELHKWE----EDEKVREACERLVQLLIRDEEEEG 55
 
Name Accession Description Interval E-value
DUF383 pfam04063
Domain of unknown function (DUF383);
103-275 6.99e-60

Domain of unknown function (DUF383);


Pssm-ID: 461153  Cd Length: 188  Bit Score: 191.60  E-value: 6.99e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16768490   103 ITNEQSDLADPWSMVLSNLTRVESLVHEILD--------TLERDDHTLPRLAKAF---AQLDYNKKkAKLHYLAPIFCNL 171
Cdd:pfam04063   2 ITDPKSPLADLACMLLSNLTKSDSICKSLLElkrssepeDLSSSGLAIDQLVDLFvkgADGGYNKH-ANYDYLAYVFANL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16768490   172 TQVSRGREL----CCHRKYELLEKLLPFASFEgSVVRRGGTIGILKNVCFDTVYHDVILNEQS-SILVAILQPLCGPEEF 246
Cdd:pfam04063  81 SQLPEGRKYfltpQEYDGVVPLSKLLVFTEHD-SVIRRGGVASTIKNCCFDTEAHEWLLSEEEiDILPYLLLPLAGPEEY 159

                         170       180
                  ....*....|....*....|....*....
gi 16768490   247 SDEDNELLPIELQYLPESKTREEDPDLRK 275
Cdd:pfam04063 160 DEEDMEKLPPELQLLPPDKKREPDPDIRL 188
DUF384 pfam04064
Domain of unknown function (DUF384);
280-338 3.80e-21

Domain of unknown function (DUF384);


Pssm-ID: 461154  Cd Length: 55  Bit Score: 85.58  E-value: 3.80e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 16768490   280 CLLQLCSTRRSREILRSRGVYEILREYHKWEakvgKDSDCLLACENVVDILIKKEEEIG 338
Cdd:pfam04064   1 SLLLLCTTREGREYLRSKGVYPILRELHKWE----EDEKVREACERLVQLLIRDEEEEG 55
 
Name Accession Description Interval E-value
DUF383 pfam04063
Domain of unknown function (DUF383);
103-275 6.99e-60

Domain of unknown function (DUF383);


Pssm-ID: 461153  Cd Length: 188  Bit Score: 191.60  E-value: 6.99e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16768490   103 ITNEQSDLADPWSMVLSNLTRVESLVHEILD--------TLERDDHTLPRLAKAF---AQLDYNKKkAKLHYLAPIFCNL 171
Cdd:pfam04063   2 ITDPKSPLADLACMLLSNLTKSDSICKSLLElkrssepeDLSSSGLAIDQLVDLFvkgADGGYNKH-ANYDYLAYVFANL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16768490   172 TQVSRGREL----CCHRKYELLEKLLPFASFEgSVVRRGGTIGILKNVCFDTVYHDVILNEQS-SILVAILQPLCGPEEF 246
Cdd:pfam04063  81 SQLPEGRKYfltpQEYDGVVPLSKLLVFTEHD-SVIRRGGVASTIKNCCFDTEAHEWLLSEEEiDILPYLLLPLAGPEEY 159

                         170       180
                  ....*....|....*....|....*....
gi 16768490   247 SDEDNELLPIELQYLPESKTREEDPDLRK 275
Cdd:pfam04063 160 DEEDMEKLPPELQLLPPDKKREPDPDIRL 188
DUF384 pfam04064
Domain of unknown function (DUF384);
280-338 3.80e-21

Domain of unknown function (DUF384);


Pssm-ID: 461154  Cd Length: 55  Bit Score: 85.58  E-value: 3.80e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 16768490   280 CLLQLCSTRRSREILRSRGVYEILREYHKWEakvgKDSDCLLACENVVDILIKKEEEIG 338
Cdd:pfam04064   1 SLLLLCTTREGREYLRSKGVYPILRELHKWE----EDEKVREACERLVQLLIRDEEEEG 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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