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Conserved domains on  [gi|16604647|gb|AAL24116|]
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putative RNA polymerase sigma-70 factor [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Sig70-cyanoRpoD super family cl37206
RNA polymerase sigma factor, cyanobacterial RpoD-like family; This family includes a number of ...
247-531 2.35e-100

RNA polymerase sigma factor, cyanobacterial RpoD-like family; This family includes a number of closely related sigma-70 (TIGR02937) factors in the cyanobacteria. All appear most closely related to the essential sigma-70 factor RpoD, and some score above trusted to the RpoD C-terminal domain model (TIGR02393).


The actual alignment was detected with superfamily member TIGR02997:

Pssm-ID: 274382 [Multi-domain]  Cd Length: 298  Bit Score: 305.32  E-value: 2.35e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647   247 LLTAKEEAELISHIQHLLKLEKVKTKLESQNGCEPTIGEWAEAMGISSPVLKSDIHRGRSSREKLITANLRLVVHIAKQY 326
Cdd:TIGR02997  15 LLTPEEEIELARQVQQMMVLEELREELEEQLGREPSKEEWAAAAGLSEAELRQRLRQGQRAKEKMIKANLRLVVSVAKKY 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647   327 QNRGLNFQDLLQEGSMGLMKSVEKFKPQSGCRFATYAYWWIRQSIRKSIFQNSRTIRLPENVYMLLGKVSEARKTCVQEG 406
Cdd:TIGR02997  95 QNRGLELLDLIQEGSLGLERAVEKFDPTRGYKFSTYAYWWIRQGITRAIANQSRTIRLPIHITEKLNKIKKVQRELSQKL 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647   407 NYRPSKEELAGHVGVSTEKLDKLLYNTRTPLSMQQPIWSDQDTTFQEITPDSGiETPTMSVGKQLMRNHVRNLLNVLSPK 486
Cdd:TIGR02997 175 GRTPSEAEIAEALELEPEQVRELLQRARQPVSLDAPVGDEEDTELGDLLEDDG-ESPEEQVERESLRQDLESLLAELTPR 253
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 16604647   487 ERRIIKLRFGIDGGKQRSLSEIGEIYGLSKERVRQLESRALYRLK 531
Cdd:TIGR02997 254 ERQVLRLRFGLDGGEPLTLAEIGRRLNLSRERVRQIEAKALRKLR 298
 
Name Accession Description Interval E-value
Sig70-cyanoRpoD TIGR02997
RNA polymerase sigma factor, cyanobacterial RpoD-like family; This family includes a number of ...
247-531 2.35e-100

RNA polymerase sigma factor, cyanobacterial RpoD-like family; This family includes a number of closely related sigma-70 (TIGR02937) factors in the cyanobacteria. All appear most closely related to the essential sigma-70 factor RpoD, and some score above trusted to the RpoD C-terminal domain model (TIGR02393).


Pssm-ID: 274382 [Multi-domain]  Cd Length: 298  Bit Score: 305.32  E-value: 2.35e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647   247 LLTAKEEAELISHIQHLLKLEKVKTKLESQNGCEPTIGEWAEAMGISSPVLKSDIHRGRSSREKLITANLRLVVHIAKQY 326
Cdd:TIGR02997  15 LLTPEEEIELARQVQQMMVLEELREELEEQLGREPSKEEWAAAAGLSEAELRQRLRQGQRAKEKMIKANLRLVVSVAKKY 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647   327 QNRGLNFQDLLQEGSMGLMKSVEKFKPQSGCRFATYAYWWIRQSIRKSIFQNSRTIRLPENVYMLLGKVSEARKTCVQEG 406
Cdd:TIGR02997  95 QNRGLELLDLIQEGSLGLERAVEKFDPTRGYKFSTYAYWWIRQGITRAIANQSRTIRLPIHITEKLNKIKKVQRELSQKL 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647   407 NYRPSKEELAGHVGVSTEKLDKLLYNTRTPLSMQQPIWSDQDTTFQEITPDSGiETPTMSVGKQLMRNHVRNLLNVLSPK 486
Cdd:TIGR02997 175 GRTPSEAEIAEALELEPEQVRELLQRARQPVSLDAPVGDEEDTELGDLLEDDG-ESPEEQVERESLRQDLESLLAELTPR 253
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 16604647   487 ERRIIKLRFGIDGGKQRSLSEIGEIYGLSKERVRQLESRALYRLK 531
Cdd:TIGR02997 254 ERQVLRLRFGLDGGEPLTLAEIGRRLNLSRERVRQIEAKALRKLR 298
RpoD COG0568
DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) [Transcription]; DNA-directed RNA ...
302-544 6.06e-96

DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) [Transcription]; DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 440334 [Multi-domain]  Cd Length: 268  Bit Score: 292.73  E-value: 6.06e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647 302 HRGRSSREKLITANLRLVVHIAKQYQNRGLNFQDLLQEGSMGLMKSVEKFKPQSGCRFATYAYWWIRQSIRKSIFQNSRT 381
Cdd:COG0568  26 AGDEEAKRKLVEANLRLVVSIAKKYQGRGLPLLDLIQEGNLGLMKAVEKFDPERGFRFSTYATWWIRQAITRAIADQWRT 105
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647 382 IRLPENVYMLLGKVSEARKTCVQEGNYRPSKEELAGHVGVSTEKLDKLLYNTRTPLSMQQPIWSDQDTTFQEITPDSGIE 461
Cdd:COG0568 106 IRLPVHMAETLNKLRRAKRQLLQELGREPTPEEIAEELGVPEEKVREMLRLAREPVSLDAPVGDDEDSELGDLLEDEEAP 185
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647 462 TPTMSVGKQLMRNHVRNLLNVLSPKERRIIKLRFGIDGGKQRSLSEIGEIYGLSKERVRQLESRALYRLKQNMNSHGLHA 541
Cdd:COG0568 186 SPEEALEEELLREELREALDTLTEREREILRLRFGLDDGEPHTLEEIGKEFGVSRERVRQIEAKALRKLRHPLRSRKLRD 265

                ...
gi 16604647 542 YAD 544
Cdd:COG0568 266 YLD 268
PRK07406 PRK07406
RNA polymerase sigma factor RpoD; Validated
203-536 3.98e-89

RNA polymerase sigma factor RpoD; Validated


Pssm-ID: 236012 [Multi-domain]  Cd Length: 373  Bit Score: 278.98  E-value: 3.98e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  203 APKSNDVDDEGYVPQKTSAKKKY-KQGADNDDALQLFLWGPETKQLLTAKEEAELISHIQHLLKLEKVKTKLESQNGCEP 281
Cdd:PRK07406  32 SSENADELSEKEAKAKALARIKIgPKKVYTEDSIRVYLQEIGRIRLLRPDEEIELARKIADLLELEELREQFESELGREP 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  282 TIGEWAEAMGISSPVLKSDIHRGRSSREKLITANLRLVVHIAKQYQNRGLNFQDLLQEGSMGLMKSVEKFKPQSGCRFAT 361
Cdd:PRK07406 112 SDKEWAELVDMPLPKFRRRLMLGRRAKEKMVQSNLRLVVSIAKKYMNRGLSFQDLIQEGSLGLIRAAEKFDHEKGYKFST 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  362 YAYWWIRQSIRKSIFQNSRTIRLPENVYMLLGKVSEARKTCVQEGNYRPSKEELAGHVGVSTEKLDKLLYNTRTPLSMQQ 441
Cdd:PRK07406 192 YATWWIRQAITRAIADQSRTIRLPVHLYETISRIKKTTKVLSQEFGRKPTEEEIAESMEMTIEKLRFIAKSAQLPISLET 271
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  442 PIWSDQDTTFQEITpDSGIETPTMSVGKQLMRNHVRNLLNVLSPKERRIIKLRFGIDGGKQRSLSEIGEIYGLSKERVRQ 521
Cdd:PRK07406 272 PIGKEEDSRLGDFI-EADGETPEDDVAKNLLREDLEGVLATLSPRERDVLRLRYGLDDGRMKTLEEIGQIFNVTRERIRQ 350
                        330
                 ....*....|....*.
gi 16604647  522 LESRALYRLKQ-NMNS 536
Cdd:PRK07406 351 IEAKALRKLRHpNRNS 366
Sigma70_r2 pfam04542
Sigma-70 region 2; Region 2 of sigma-70 is the most conserved region of the entire protein. ...
311-381 1.47e-19

Sigma-70 region 2; Region 2 of sigma-70 is the most conserved region of the entire protein. All members of this class of sigma-factor contain region 2. The high conservation is due to region 2 containing both the -10 promoter recognition helix and the primary core RNA polymerase binding determinant. The core binding helix, interacts with the clamp domain of the largest polymerase subunit, beta prime. The aromatic residues of the recognition helix, found at the C-terminus of this domain are though to mediate strand separation, thereby allowing transcription initiation.


Pssm-ID: 427998 [Multi-domain]  Cd Length: 71  Bit Score: 82.64  E-value: 1.47e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16604647   311 LITANLRLVVHIAKQYQNRGLNFQDLLQEGSMGLMKSVEKFKPQSGCRFATYAYWWIRQSIRKSIFQNSRT 381
Cdd:pfam04542   1 LVERYLPLVYSLARRYLGDGADAEDLVQEGFLGLWRAIERFDPERGVSFSTWLYTIIRNAIIDYLRKQRRT 71
Sigma70_r4 cd06171
Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in ...
473-531 4.85e-11

Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or plastid core RNA polymerase to specific promoter elements located upstream of transcription initiation points. The SR4 of Ec sigma70 and other essential primary SFs contact promoter sequences located 35 base-pairs upstream of the initiation point, recognizing a 6-base-pair -35 consensus TTGACA. Sigma70 related SFs also include SFs which are dispensable for bacterial cell growth for example Ec sigmaS, SFs which activate regulons in response to a specific signal for example heat-shock Ec sigmaH, and a group of SFs which includes the extracytoplasmic function (ECF) SFs and is typified by Ec sigmaE which contains SR2 and -4 only. ECF SFs direct the transcription of genes that regulate various responses including periplasmic stress and pathogenesis. Ec sigmaE SR4 also contacts the -35 element, but recognizes a different consensus (a 7-base-pair GGAACTT). Plant SFs recognize sigma70 type promoters and direct transcription of the major plastid RNA polymerase, plastid-encoded RNA polymerase (PEP).


Pssm-ID: 100119 [Multi-domain]  Cd Length: 55  Bit Score: 57.88  E-value: 4.85e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 16604647 473 RNHVRNLLNVLSPKERRIIKLRFGidggKQRSLSEIGEIYGLSKERVRQLESRALYRLK 531
Cdd:cd06171   1 RERLEEALDKLPEREREVILLRFG----EGLSYEEIAEILGISRSTVRQRLHRALKKLR 55
 
Name Accession Description Interval E-value
Sig70-cyanoRpoD TIGR02997
RNA polymerase sigma factor, cyanobacterial RpoD-like family; This family includes a number of ...
247-531 2.35e-100

RNA polymerase sigma factor, cyanobacterial RpoD-like family; This family includes a number of closely related sigma-70 (TIGR02937) factors in the cyanobacteria. All appear most closely related to the essential sigma-70 factor RpoD, and some score above trusted to the RpoD C-terminal domain model (TIGR02393).


Pssm-ID: 274382 [Multi-domain]  Cd Length: 298  Bit Score: 305.32  E-value: 2.35e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647   247 LLTAKEEAELISHIQHLLKLEKVKTKLESQNGCEPTIGEWAEAMGISSPVLKSDIHRGRSSREKLITANLRLVVHIAKQY 326
Cdd:TIGR02997  15 LLTPEEEIELARQVQQMMVLEELREELEEQLGREPSKEEWAAAAGLSEAELRQRLRQGQRAKEKMIKANLRLVVSVAKKY 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647   327 QNRGLNFQDLLQEGSMGLMKSVEKFKPQSGCRFATYAYWWIRQSIRKSIFQNSRTIRLPENVYMLLGKVSEARKTCVQEG 406
Cdd:TIGR02997  95 QNRGLELLDLIQEGSLGLERAVEKFDPTRGYKFSTYAYWWIRQGITRAIANQSRTIRLPIHITEKLNKIKKVQRELSQKL 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647   407 NYRPSKEELAGHVGVSTEKLDKLLYNTRTPLSMQQPIWSDQDTTFQEITPDSGiETPTMSVGKQLMRNHVRNLLNVLSPK 486
Cdd:TIGR02997 175 GRTPSEAEIAEALELEPEQVRELLQRARQPVSLDAPVGDEEDTELGDLLEDDG-ESPEEQVERESLRQDLESLLAELTPR 253
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 16604647   487 ERRIIKLRFGIDGGKQRSLSEIGEIYGLSKERVRQLESRALYRLK 531
Cdd:TIGR02997 254 ERQVLRLRFGLDGGEPLTLAEIGRRLNLSRERVRQIEAKALRKLR 298
RpoD COG0568
DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) [Transcription]; DNA-directed RNA ...
302-544 6.06e-96

DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) [Transcription]; DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 440334 [Multi-domain]  Cd Length: 268  Bit Score: 292.73  E-value: 6.06e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647 302 HRGRSSREKLITANLRLVVHIAKQYQNRGLNFQDLLQEGSMGLMKSVEKFKPQSGCRFATYAYWWIRQSIRKSIFQNSRT 381
Cdd:COG0568  26 AGDEEAKRKLVEANLRLVVSIAKKYQGRGLPLLDLIQEGNLGLMKAVEKFDPERGFRFSTYATWWIRQAITRAIADQWRT 105
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647 382 IRLPENVYMLLGKVSEARKTCVQEGNYRPSKEELAGHVGVSTEKLDKLLYNTRTPLSMQQPIWSDQDTTFQEITPDSGIE 461
Cdd:COG0568 106 IRLPVHMAETLNKLRRAKRQLLQELGREPTPEEIAEELGVPEEKVREMLRLAREPVSLDAPVGDDEDSELGDLLEDEEAP 185
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647 462 TPTMSVGKQLMRNHVRNLLNVLSPKERRIIKLRFGIDGGKQRSLSEIGEIYGLSKERVRQLESRALYRLKQNMNSHGLHA 541
Cdd:COG0568 186 SPEEALEEELLREELREALDTLTEREREILRLRFGLDDGEPHTLEEIGKEFGVSRERVRQIEAKALRKLRHPLRSRKLRD 265

                ...
gi 16604647 542 YAD 544
Cdd:COG0568 266 YLD 268
PRK07406 PRK07406
RNA polymerase sigma factor RpoD; Validated
203-536 3.98e-89

RNA polymerase sigma factor RpoD; Validated


Pssm-ID: 236012 [Multi-domain]  Cd Length: 373  Bit Score: 278.98  E-value: 3.98e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  203 APKSNDVDDEGYVPQKTSAKKKY-KQGADNDDALQLFLWGPETKQLLTAKEEAELISHIQHLLKLEKVKTKLESQNGCEP 281
Cdd:PRK07406  32 SSENADELSEKEAKAKALARIKIgPKKVYTEDSIRVYLQEIGRIRLLRPDEEIELARKIADLLELEELREQFESELGREP 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  282 TIGEWAEAMGISSPVLKSDIHRGRSSREKLITANLRLVVHIAKQYQNRGLNFQDLLQEGSMGLMKSVEKFKPQSGCRFAT 361
Cdd:PRK07406 112 SDKEWAELVDMPLPKFRRRLMLGRRAKEKMVQSNLRLVVSIAKKYMNRGLSFQDLIQEGSLGLIRAAEKFDHEKGYKFST 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  362 YAYWWIRQSIRKSIFQNSRTIRLPENVYMLLGKVSEARKTCVQEGNYRPSKEELAGHVGVSTEKLDKLLYNTRTPLSMQQ 441
Cdd:PRK07406 192 YATWWIRQAITRAIADQSRTIRLPVHLYETISRIKKTTKVLSQEFGRKPTEEEIAESMEMTIEKLRFIAKSAQLPISLET 271
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  442 PIWSDQDTTFQEITpDSGIETPTMSVGKQLMRNHVRNLLNVLSPKERRIIKLRFGIDGGKQRSLSEIGEIYGLSKERVRQ 521
Cdd:PRK07406 272 PIGKEEDSRLGDFI-EADGETPEDDVAKNLLREDLEGVLATLSPRERDVLRLRYGLDDGRMKTLEEIGQIFNVTRERIRQ 350
                        330
                 ....*....|....*.
gi 16604647  522 LESRALYRLKQ-NMNS 536
Cdd:PRK07406 351 IEAKALRKLRHpNRNS 366
PRK05949 PRK05949
RNA polymerase sigma factor; Validated
247-532 5.44e-73

RNA polymerase sigma factor; Validated


Pssm-ID: 180321 [Multi-domain]  Cd Length: 327  Bit Score: 235.51  E-value: 5.44e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  247 LLTAKEEAELISHIQHLLKLEKVKTKLESQNGCEPTIGEWAEAMGISSPVLKSDIHRGRSSREKLITANLRLVVHIAKQY 326
Cdd:PRK05949  32 LLTHEQEIVYGKQVQQMMSLLEAKEALAKKLGREPSLPEWAEAVNLSETELKQTLKQGKRAKQKMIEANLRLVVAIAKKY 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  327 QNRGLNFQDLLQEGSMGLMKSVEKFKPQSGCRFATYAYWWIRQSIRKSIFQNSRTIRLPENVYMLLGKVSEARKTCVQEG 406
Cdd:PRK05949 112 QKRNMEFLDLIQEGTLGLERGVEKFDPTRGYKFSTYAYWWIRQAITRAIAQQARTIRLPIHITEKLNKIKKTQRELSQKL 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  407 NYRPSKEELAGHVGVSTEKLDKLLYNTRTPLSMQQPIWSDQDTTFQEITPDSGIeTPTMSVGKQLMRNHVRNLLNVLSPK 486
Cdd:PRK05949 192 GRSATPAEIAKELELEPSQIREYLSMARQPISLDVRVGDNQDTELSELLEDEGP-SPDQYITQELLRQDLNNLLAELTPQ 270
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 16604647  487 ERRIIKLRFGIDGGKQRSLSEIGEIYGLSKERVRQLESRALYRLKQ 532
Cdd:PRK05949 271 QREVLTLRFGLEDGKELSLAKVGERLNLSRERVRQLEHQALAHLRR 316
PRK07405 PRK07405
RNA polymerase sigma factor SigD; Validated
247-537 1.61e-68

RNA polymerase sigma factor SigD; Validated


Pssm-ID: 180963 [Multi-domain]  Cd Length: 317  Bit Score: 223.48  E-value: 1.61e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  247 LLTAKEEAELISHIQHLLKLEKVKTKLESQNGCEPTIGEWAEAMGISSPVLKSDIHRGRSSREKLITANLRLVVHIAKQY 326
Cdd:PRK07405  22 LLTHEEEILYGKQVQRLVALQEIREELAEELGREPTDAEWAKAAKLSEEELRSAIAEGEAAKRKMVEANLRLVVSVAKKY 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  327 QNRGLNFQDLLQEGSMGLMKSVEKFKPQSGCRFATYAYWWIRQSIRKSIFQNSRTIRLPENVYMLLGKVSEARKTCVQEG 406
Cdd:PRK07405 102 LKRNVDLLDLIQEGTIGMQRGVEKFDPTKGYRFSTYAYWWIRQAITRAIAEKSRTIRLPIHITEKLNKIKKAQRQLSQQL 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  407 NYRPSKEELAGHVGVSTEKLDKLLYNTRTPLSMQQPIWSDQDTTFQEITPDSGiETPTMSVGKQLMRNHVRNLLNVLSPK 486
Cdd:PRK07405 182 GRAATIGELAEELELTPKQVREYLERARQPLSLDLRVGDNQDTELGELLEDTG-ASPEDFATQSSLQLDLERLMEDLTPQ 260
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 16604647  487 ERRIIKLRFGIDGGKQRSLSEIGEIYGLSKERVRQLESRALYRL---KQNMNSH 537
Cdd:PRK07405 261 QKEVIALRFGLEDGQPLTLAKIGERLNISRERVRQIEREALSKLrkrKANIQEY 314
PRK07921 PRK07921
RNA polymerase sigma factor SigB; Reviewed
233-543 1.43e-66

RNA polymerase sigma factor SigB; Reviewed


Pssm-ID: 181169 [Multi-domain]  Cd Length: 324  Bit Score: 218.83  E-value: 1.43e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  233 DALQLFLWGPETKQLLTAKEEAELISHIQHLLKLEkvkTKLESqngCEPTigewaeamgisSPVLKSDI----HRGRSSR 308
Cdd:PRK07921  26 DLVRVYLNGIGKTALLTAADEVELAKRIEAGLYAE---HLLET---RKRL-----------SEARKRDLaavvRDGEAAR 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  309 EKLITANLRLVVHIAKQYQNRGLNFQDLLQEGSMGLMKSVEKFKPQSGCRFATYAYWWIRQSIRKSIFQNSRTIRLPENV 388
Cdd:PRK07921  89 RHLLEANLRLVVSLAKRYTGRGMPLLDLIQEGNLGLIRAMEKFDYTKGFKFSTYATWWIRQAITRGMADQSRTIRLPVHL 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  389 YMLLGKVSEARKTCVQEGNYRPSKEELAGHVGVSTEKLDKLLYNTRTPLSMQQPIWSDQDTTFQEITPDSGIETPTMSVG 468
Cdd:PRK07921 169 VEQVNKLARIKRELHQQLGREATDEELAEESGIPEEKIADLLEHSRDPVSLDMPVGSDEEAPLGDFIEDSEATSAENAVI 248
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16604647  469 KQLMRNHVRNLLNVLSPKERRIIKLRFGIDGGKQRSLSEIGEIYGLSKERVRQLESRALYRLKQNMNSHGLHAYA 543
Cdd:PRK07921 249 AGLLHTDIRSVLATLDEREQQVIRLRFGLDDGQPRTLDQIGKLFGLSRERVRQIEREVMSKLRNGERADRLRSYA 323
PRK07598 PRK07598
RNA polymerase sigma factor SigC; Validated
245-532 1.70e-63

RNA polymerase sigma factor SigC; Validated


Pssm-ID: 236067 [Multi-domain]  Cd Length: 415  Bit Score: 213.58  E-value: 1.70e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  245 KQLLTAKEEAELISHIQHLLKLEKVKTKLESQNGCEPTIGEWAEAMGIS----SPVLKSDIHR----------------- 303
Cdd:PRK07598  92 KLIVLANAAKEGDEVIKPYLRLIEVRERLTSELGHRPSLERWAKTADISladlKPTLAEGKRRwaeiakltveeleqiqk 171
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  304 -GRSSREKLITANLRLVVHIAKQYQNRGLNFQDLLQEGSMGLMKSVEKFKPQSGCRFATYAYWWIRQSIRKSIFQNSRTI 382
Cdd:PRK07598 172 qGLRAKEHMIKANLRLVVSVAKKYQNRGLELLDLVQEGTLGLERAVEKFDPTKGYRFSTYAYWWIRQGITRAIATQSRTI 251
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  383 RLPENVYMLLGKVSEARKTCVQEGNYRPSKEELAGHVGVSTEKLDKLLYNTRTPLSMQQPIWSDQDTTFQEITPDSGIeT 462
Cdd:PRK07598 252 RLPVHITEKLNKIKKAQRKISQEKGRTPTIEDIAQELEMTPTQVREVLLRVPRSVSLETKVGKDKDTELGDLLETDDI-S 330
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  463 PTMSVGKQLMRNHVRNLLNVLSPKERRIIKLRFGIDGGKQRSLSEIGEIYGLSKERVRQLESRALYRLKQ 532
Cdd:PRK07598 331 PEEMLMRESLQRDLQHLLADLTSRERDVIRMRFGLADGHTYSLAEIGRALDLSRERVRQIESKALQKLRQ 400
PRK05901 PRK05901
RNA polymerase sigma factor; Provisional
247-531 2.30e-59

RNA polymerase sigma factor; Provisional


Pssm-ID: 235640 [Multi-domain]  Cd Length: 509  Bit Score: 204.84  E-value: 2.30e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  247 LLTAKEEAELISHIQHLLKLEKvktKLESQNGCEPTIGEwaEAMGISspvlksdiHRGRSSREKLITANLRLVVHIAKQY 326
Cdd:PRK05901 225 LLNAEEEVELAKRIEAGLYAEE---LLAEGEKLDPELRR--DLQWIG--------RDGKRAKNHLLEANLRLVVSLAKRY 291
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  327 QNRGLNFQDLLQEGSMGLMKSVEKFKPQSGCRFATYAYWWIRQSIRKSIFQNSRTIRLPenVYML-----LGKVseARKT 401
Cdd:PRK05901 292 TNRGLSFLDLIQEGNLGLIKAVEKFDYTKGYKFSTYATWWIRQAITRAMADQARTIRIP--VHMVetinkLGRI--EREL 367
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  402 cVQEGNYRPSKEELAGHVGVSTEK---LDKllYNtRTPLSMQQPIWSDQDTTFQEITPDSGIETPTMSVGKQLMRNHVRN 478
Cdd:PRK05901 368 -LQELGREPTPEELAKEMGFTPEKvreIQK--YN-REPISLDKTIGKEGDSQFGDFIEDSEAVSPVDAVSFTLLQDQLQE 443
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 16604647  479 LLNVLSPKERRIIKLRFGIDGGKQRSLSEIGEIYGLSKERVRQLESRALYRLK 531
Cdd:PRK05901 444 VLETLSEREAGVIRMRFGLTDGQPKTLDEIGQVYGVTRERIRQIESKTLRKLR 496
PRK09210 PRK09210
RNA polymerase sigma factor RpoD; Validated
307-544 3.70e-57

RNA polymerase sigma factor RpoD; Validated


Pssm-ID: 236413 [Multi-domain]  Cd Length: 367  Bit Score: 195.20  E-value: 3.70e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  307 SREKLITANLRLVVHIAKQYQNRGLNFQDLLQEGSMGLMKSVEKFKPQSGCRFATYAYWWIRQSIRKSIFQNSRTIRLPe 386
Cdd:PRK09210 130 AKQRLAEANLRLVVSIAKRYVGRGMLFLDLIQEGNMGLMKAVEKFDYRKGFKFSTYATWWIRQAITRAIADQARTIRIP- 208
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  387 nVYML--LGKVSEARKTCVQEGNYRPSKEELAGHVGVSTEKLDKLLYNTRTPLSMQQPIWSDQDTTFQEITPDSGIETPT 464
Cdd:PRK09210 209 -VHMVetINKLIRVQRQLLQELGREPTPEEIAEEMDMPPEKVREILKIAQEPVSLETPIGEEDDSHLGDFIEDQDATSPA 287
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  465 MSVGKQLMRNHVRNLLNVLSPKERRIIKLRFGIDGGKQRSLSEIGEIYGLSKERVRQLESRALYRLKQNMNSHGLHAYAD 544
Cdd:PRK09210 288 DHAAYELLKEQLEDVLDTLTDREENVLRLRFGLDDGRTRTLEEVGKVFGVTRERIRQIEAKALRKLRHPSRSKQLKDFLE 367
PRK05658 PRK05658
RNA polymerase sigma factor RpoD; Validated
301-531 5.04e-52

RNA polymerase sigma factor RpoD; Validated


Pssm-ID: 235549 [Multi-domain]  Cd Length: 619  Bit Score: 187.31  E-value: 5.04e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  301 IHRG-RSSRE---KLITANLRLVVHIAKQYQNRGLNFQDLLQEGSMGLMKSVEKFKPQSGCRFATYAYWWIRQSIRKSIF 376
Cdd:PRK05658 371 ISKGeAKARRakkEMVEANLRLVISIAKKYTNRGLQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTYATWWIRQAITRSIA 450
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  377 QNSRTIRLPenVYML-----LGKVSeaRKtCVQEGNYRPSKEELAGHVGVSTEKLDKLLYNTRTPLSMQQPIWSDQDTTF 451
Cdd:PRK05658 451 DQARTIRIP--VHMIetinkLNRIS--RQ-MLQEIGREPTPEELAERLGMPEDKVRKVLKIAKEPISLETPIGDDEDSHL 525
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  452 QEITPDSGIETPTMSVGKQLMRNHVRNLLNVLSPKERRIIKLRFGIDGGKQRSLSEIGEIYGLSKERVRQLESRALYRLK 531
Cdd:PRK05658 526 GDFIEDKNAELPIDAAIQESLREATTDVLASLTPREAKVLRMRFGIDMNTDHTLEEVGKQFDVTRERIRQIEAKALRKLR 605
PRK05657 PRK05657
RNA polymerase sigma factor RpoS; Validated
306-539 6.22e-52

RNA polymerase sigma factor RpoS; Validated


Pssm-ID: 235548 [Multi-domain]  Cd Length: 325  Bit Score: 180.15  E-value: 6.22e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  306 SSREKLITANLRLVVHIAKQYQNRGLNFQDLLQEGSMGLMKSVEKFKPQSGCRFATYAYWWIRQSIRKSIFQNSRTIRLP 385
Cdd:PRK05657  86 AARQRMIESNLRLVVKIAKRYLNRGLALLDLIEEGNLGLIRAVEKFDPERGFRFSTYATWWIRQTIERAIMNQTRTIRLP 165
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  386 ENVYMLLGKVSEARKTCVQEGNYRPSKEELAGHVGVSTEKLDKLL-YNTRTpLSMQQPIWSDQDTTFQEITPDSGIETPT 464
Cdd:PRK05657 166 VHVVKELNVYLRAARELEHKLDHEPSAEEIAELLDKPVDDVSRMLaLNERI-TSLDTPLGGDPEKSLLDILADEQENGPE 244
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16604647  465 MSVGKQLMRNHVRNLLNVLSPKERRIIKLRFGIDGGKQRSLSEIGEIYGLSKERVRQLESRALYRLKQNMNSHGL 539
Cdd:PRK05657 245 DTTQDDDMKQSIVKWLFELNDKQREVLARRFGLLGYEAATLEDVAREIGLTRERVRQIQVEALRRLREILQTQGL 319
FliA COG1191
DNA-directed RNA polymerase specialized sigma subunit [Transcription]; DNA-directed RNA ...
308-536 1.87e-39

DNA-directed RNA polymerase specialized sigma subunit [Transcription]; DNA-directed RNA polymerase specialized sigma subunit is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 440804 [Multi-domain]  Cd Length: 236  Bit Score: 143.81  E-value: 1.87e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647 308 REKLITANLRLVVHIAKQYQNRGL-NFQDLLQEGSMGLMKSVEKFKPQSGCRFATYAYWWIRQSIRKSIFQNSrtiRLPE 386
Cdd:COG1191  17 REELIEEYLPLVKKIASRLAGRLPaELDDLIQVGLIGLIEAIDRFDPSKGVSFETYAVPRIRGAILDYLRDED---WVPR 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647 387 NVYMLLGKVSEARKTCVQEGNYRPSKEELAGHVGVSTEKLDKLL--YNTRTPLSMQQPIWSDQDT--TFQEITPDSGIEt 462
Cdd:COG1191  94 SVRELARKIEEAIEELEQELGREPTDEEIAEELGISLEEVQEALeaANAYQLLSLDEPLEDGDDLldLLESGDPEEELE- 172
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16604647 463 ptmsvgKQLMRNHVRNLLNVLSPKERRIIKLRFgidgGKQRSLSEIGEIYGLSKERVRQLESRALYRLKQNMNS 536
Cdd:COG1191 173 ------HEELREALAEAIEQLPERERLVLSLYY----FEELTLKEIAEVLGVSESRVSRLHKKALARLREYLKE 236
rpoH2 PRK07500
RNA polymerase factor sigma-32; Reviewed
302-545 6.62e-34

RNA polymerase factor sigma-32; Reviewed


Pssm-ID: 236033 [Multi-domain]  Cd Length: 289  Bit Score: 130.16  E-value: 6.62e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  302 HRGRSSREKLITANLRLVVHIAKQYQNRGLNFQDLLQEGSMGLMKSVEKFKPQSGCRFATYAYWWIRQSIRKSIFQNSRT 381
Cdd:PRK07500  36 HRDEDALHRIISAHMRLVISMAGKFRRFGLPMNDLIQEGYVGLLEAAARFEPDREVRFSTYATWWIRASIQDYILRNWSI 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  382 IR---------LPENVYMLLGKVSEARKTCVQEGNYRpskeELAGHVGVST---EKLDKLLynTRTPLSMQQPIWSDQDT 449
Cdd:PRK07500 116 VRggtssaqkaLFFNLRRLRARLAQADEELTKQEIHR----EIATALGVSLsdvEMMDARL--SGPDASLNAPQSEEDEG 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  450 TFQEI--------TPDsgiETPTMSVGKQLMRNHVRNLLNVLSPKERRIIKLRFGIDGGkqRSLSEIGEIYGLSKERVRQ 521
Cdd:PRK07500 190 RSERMdflvddspLPD---EQVESSIDGERRRRWLTQALQTLNERELRIIRERRLREDG--ATLEALGEELGISKERVRQ 264
                        250       260
                 ....*....|....*....|....
gi 16604647  522 LESRALYRLKQNMNSHGLHAYADL 545
Cdd:PRK07500 265 IEARALEKLRRALLSQSPEVAYFA 288
rpoH_proteo TIGR02392
alternative sigma factor RpoH; A sigma factor is a DNA-binding protein protein that binds to ...
310-536 1.94e-31

alternative sigma factor RpoH; A sigma factor is a DNA-binding protein protein that binds to the DNA-directed RNA polymerase core to produce the holoenzyme capable of initiating transcription at specific sites. Different sigma factors act in vegetative growth, heat shock, extracytoplasmic functions (ECF), etc. This model represents the clade of sigma factors called RpoH and further restricted to the Proteobacteria. This protein may be called sigma-32, sigma factor H, heat shock sigma factor, and alternative sigma factor RpoH. Note that in some species the single locus rpoH may be replaced by two or more differentially regulated stress response sigma factors. [Cellular processes, Adaptations to atypical conditions, Transcription, Transcription factors]


Pssm-ID: 274107 [Multi-domain]  Cd Length: 270  Bit Score: 122.77  E-value: 1.94e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647   310 KLITANLRLVVHIAKQYQNRGLNFQDLLQEGSMGLMKSVEKFKPQSGCRFATYAYWWIRQSIRKSIFQNSR-----TIRL 384
Cdd:TIGR02392  39 KLVLSHLRFVVKIARGYRGYGLPQADLIQEGNIGLMKAVKRFDPERGVRLVSFAVHWIKAEIHEYILRNWRlvkvaTTKA 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647   385 PENVYMLLGKVSEARKtcvqeGNYRPSK-EELAGHVGVSTEklDKLLYNTR---TPLSMQQPIWSDQDTTFQEIT--PDS 458
Cdd:TIGR02392 119 QRKLFFNLRKMKKRLQ-----GWLNPEEvEAIAEELGVSER--EVREMESRlsgQDMSLNASIDDDEDDGGAPIAylVDK 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647   459 GIETPTMSVGKQ---LMRNHVRNLLNVLSPKERRIIKLRFGIDGGKqrSLSEIGEIYGLSKERVRQLESRALYRLKQNMN 535
Cdd:TIGR02392 192 RSDPEDTLEEEQweeLQRQALANALGSLDARSRRIIEARWLDDDKL--TLQELAAEYGVSAERIRQIEKNAMKKLKAALA 269

                  .
gi 16604647   536 S 536
Cdd:TIGR02392 270 A 270
PRK06596 PRK06596
RNA polymerase factor sigma-32; Reviewed
310-534 2.64e-29

RNA polymerase factor sigma-32; Reviewed


Pssm-ID: 235838 [Multi-domain]  Cd Length: 284  Bit Score: 117.20  E-value: 2.64e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  310 KLITANLRLVVHIAKQYQNRGLNFQDLLQEGSMGLMKSVEKFKPQSGCRFATYAYWWIRQSIRKSIFQNSRTIRlpenvy 389
Cdd:PRK06596  52 QLVLSHLRFVVHIARGYRGYGLPQADLIQEGNIGLMKAVKRFDPEVGVRLVSFAVHWIKAEIHEYILRNWRIVK------ 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  390 mlLGKVSEARKTCVqegNYRPSK-----------EELAGHVGVSTEklDKLLYNTR---TPLSMQQPIWSDQDTTFQEIT 455
Cdd:PRK06596 126 --VATTKAQRKLFF---NLRKAKkrlgwlnpeevEMVAEELGVSEE--EVREMESRlsgQDASLDAPIDDDDEESGAPQD 198
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  456 --PDSGIETPTMSVGKQLMRNHVRNL---LNVLSPKERRIIKLRFGIDGGKqrSLSEIGEIYGLSKERVRQLESRALYRL 530
Cdd:PRK06596 199 ylEDKSSDPADVLEEDNWEDQRRALLadaLEGLDERSRDIIEARWLDDDKS--TLQELAAEYGVSAERVRQIEKNAMKKL 276

                 ....
gi 16604647  531 KQNM 534
Cdd:PRK06596 277 KAAI 280
PRK08215 PRK08215
RNA polymerase sporulation sigma factor SigG;
295-534 1.89e-26

RNA polymerase sporulation sigma factor SigG;


Pssm-ID: 181296 [Multi-domain]  Cd Length: 258  Bit Score: 108.11  E-value: 1.89e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  295 PVLKSD--------IHRG-RSSREKLITANLRLVVHIAKQYQNRGLNFQDLLQEGSMGLMKSVEKFKPQSGCRFATYAYW 365
Cdd:PRK08215  17 PVLKNEemrelferMQNGdKEAREKLINGNLRLVLSVIQRFNNRGENVDDLFQVGCIGLMKAIDNFDLSQNVKFSTYAVP 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  366 WIRQSIRKSIFQNSrTIRLPENVYMLLGKVSEARKTCVQEGNYRPSKEELAGHVGVSTEKLDKLLYNTRTPLSMQQPIWS 445
Cdd:PRK08215  97 MIIGEIRRYLRDNN-PIRVSRSLRDIAYKALQVREKLINENSKEPTVEEIAKELEVPREEVVFALDAIQDPVSLFEPIYH 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  446 DQ-DTTF--QEITPDsgietptmsvgKQLMRNHVRNL-----LNVLSPKERRIIKLRFgIDGGKQrslSEIGEIYGLSKE 517
Cdd:PRK08215 176 DGgDPIYvmDQISDE-----------KNKDENWLEEIalkeaMKKLNDREKLILNLRF-FQGKTQ---MEVAEEIGISQA 240
                        250
                 ....*....|....*..
gi 16604647  518 RVRQLESRALYRLKQNM 534
Cdd:PRK08215 241 QVSRLEKAALKHMRKYI 257
spore_sigF TIGR02885
RNA polymerase sigma-F factor; Members of this protein family are the RNA polymerase sigma ...
305-534 2.57e-25

RNA polymerase sigma-F factor; Members of this protein family are the RNA polymerase sigma factor F. Sigma-F is specifically and universally a component of the Firmicutes lineage endospore formation program, and is expressed in the forespore to turn on expression of dozens of genes. It is closely homologous to sigma-G, which is also expressed in the forespore. [Transcription, Transcription factors, Cellular processes, Sporulation and germination]


Pssm-ID: 131931 [Multi-domain]  Cd Length: 231  Bit Score: 104.41  E-value: 2.57e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647   305 RSSREKLITANLRLVVHIAKQYQNRGLNFQDLLQEGSMGLMKSVEKFKPQSGCRFATYAYWWIRQSIRKSIfQNSRTIRL 384
Cdd:TIGR02885  10 KEARDKLIECNLRLVWSIVKRFLNRGYEPEDLFQIGCIGLVKAIDKFDLSYDVKFSTYAVPMIMGEIKRFL-RDDGIIKV 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647   385 PENVYMLLGKVSEARKTCVQEGNYRPSKEELAGHVGVSTEKLDKLLYNTRTPLSMQQPIWSDQDTTFQEItpdSGIETPT 464
Cdd:TIGR02885  89 SRSLKELARKIRYMKEELSKELGREPTINELAEALGVSPEEIVMALESARSPQSLYDTVHQDDGDPIYLL---DQIADKG 165
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647   465 MSVGKQLMRNHVRNLLNVLSPKERRIIKLRFgidgGKQRSLSEIGEIYGLSKERVRQLESRALYRLKQNM 534
Cdd:TIGR02885 166 SEDSDWLEKIALKEAISKLDERERQIIMLRY----FKDKTQTEVANMLGISQVQVSRLEKKVLKKMKEKL 231
PRK05803 PRK05803
RNA polymerase sporulation sigma factor SigK;
305-538 9.36e-25

RNA polymerase sporulation sigma factor SigK;


Pssm-ID: 180266 [Multi-domain]  Cd Length: 233  Bit Score: 102.72  E-value: 9.36e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  305 RSSREKLITANLRLVVHIAKQYQNRGLNFQDLLQEGSMGLMKSVEKFKPQSGCRFATYAywwirqsirksifqnSRTIrl 384
Cdd:PRK05803  48 EEARNILIERNLRLVAHIVKKFENTGEDVDDLISIGTIGLIKAIESFDAGKGTKLATYA---------------ARCI-- 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  385 pEN-VYMLLgkvsearktcvqegnyRPSKEelaghvgvstekldkllynTRTPLSMQQPIWSDQDTTfqEIT-------- 455
Cdd:PRK05803 111 -ENeILMHL----------------RNLKK-------------------TKKEVSLQDPIGVDKEGN--EISlidilgse 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  456 PDSGIETptmsVGKQLMRNHVRNLLNVLSPKERRIIKLRFGIDGGKQRSLSEIGEIYGLSKERVRQLESRALYRLKQNMN 535
Cdd:PRK05803 153 EDDVIEQ----VELKMEVEKLYKKIDILDEREKEVIEMRYGLGNGKEKTQREIAKALGISRSYVSRIEKRALKKLFKELY 228

                 ...
gi 16604647  536 SHG 538
Cdd:PRK05803 229 RAE 231
PRK05572 PRK05572
RNA polymerase sporulation sigma factor, SigF/SigG family;
308-535 8.85e-21

RNA polymerase sporulation sigma factor, SigF/SigG family;


Pssm-ID: 180137 [Multi-domain]  Cd Length: 252  Bit Score: 91.96  E-value: 8.85e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  308 REKLITANLRLVVHIAKQYQNRGLNFQDLLQEGSMGLMKSVEKFKPQSGCRFATYAYWWIRQSIRKSIfQNSRTIRLPEN 387
Cdd:PRK05572  34 RDTLVEKNLRLVWSVVQRFLNRGYEPDDLFQIGCIGLLKAVDKFDLSYDVKFSTYAVPMIIGEIQRFL-RDDGTVKVSRS 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  388 VYMLLGKVSEARKTCVQEGNYRPSKEELAGHVGVSTEKLDKLLYNTRTPLSMQQPIWSDQD---TTFQEITPDSGietpt 464
Cdd:PRK05572 113 LKETANKIRKDKDELSKELGREPTIEELAEYLGVTPEEVVLAQEASRSPQSIHETVHENDGdpiTLLDQIADQSE----- 187
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16604647  465 msvGKQLMRNHVRNLLNVLSPKERRIIKLRFgidgGKQRSLSEIGEIYGLSKERVRQLESRALYRLKQNMN 535
Cdd:PRK05572 188 ---EDWFDKIALKEAIRELDERERLIVYLRY----FKDKTQSEVAKRLGISQVQVSRLEKKILKQMKEKLD 251
FliA_WhiG TIGR02479
RNA polymerase sigma factor, FliA/WhiG family; Most members of this family are the flagellar ...
311-534 7.64e-20

RNA polymerase sigma factor, FliA/WhiG family; Most members of this family are the flagellar operon sigma factor FliA, controlling transcription of bacterial flagellar genes by RNA polymerase. An exception is the sigma factor WhiG in the genus Streptomyces, involved in the production of sporulating aerial mycelium.


Pssm-ID: 274153 [Multi-domain]  Cd Length: 224  Bit Score: 88.48  E-value: 7.64e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647   311 LITANLRLVVHIAKQYQNR---GLNFQDLLQEGSMGLMKSVEKFKPQSGCRFATYAywwiRQSIRKSIFQNSRTIR-LPE 386
Cdd:TIGR02479   1 LIRRYLPLVKRIAGRLSVGlpsSVELDDLIQAGMFGLLDAIERYDPSRGAKFETYA----VQRIRGAMLDELRRLDwVPR 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647   387 NVYMLLGKVSEARKTCVQEGNYRPSKEELAGHVGVSTEKLDKLLY--NTRTPLSMQQPIWSDQD-TTFQEITPDSGIETP 463
Cdd:TIGR02479  77 SLRQKARKLERAIRELEARLGREPTEEEIAEELGMDLKEYRQALNeiNALSLVSLDELLESGDDgGSLIDRIEDDKSEDP 156
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16604647   464 TMSVGKQLMRNHVRNLLNVLSPKERRIIKLRFgidgGKQRSLSEIGEIYGLSKERVRQLESRALYRLKQNM 534
Cdd:TIGR02479 157 EEELEREELREALAEAIESLSEREQLVLSLYY----YEELNLKEIGEVLGLTESRVSQIHSQALKKLRAKL 223
Sigma70_r2 pfam04542
Sigma-70 region 2; Region 2 of sigma-70 is the most conserved region of the entire protein. ...
311-381 1.47e-19

Sigma-70 region 2; Region 2 of sigma-70 is the most conserved region of the entire protein. All members of this class of sigma-factor contain region 2. The high conservation is due to region 2 containing both the -10 promoter recognition helix and the primary core RNA polymerase binding determinant. The core binding helix, interacts with the clamp domain of the largest polymerase subunit, beta prime. The aromatic residues of the recognition helix, found at the C-terminus of this domain are though to mediate strand separation, thereby allowing transcription initiation.


Pssm-ID: 427998 [Multi-domain]  Cd Length: 71  Bit Score: 82.64  E-value: 1.47e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16604647   311 LITANLRLVVHIAKQYQNRGLNFQDLLQEGSMGLMKSVEKFKPQSGCRFATYAYWWIRQSIRKSIFQNSRT 381
Cdd:pfam04542   1 LVERYLPLVYSLARRYLGDGADAEDLVQEGFLGLWRAIERFDPERGVSFSTWLYTIIRNAIIDYLRKQRRT 71
sigma70-ECF TIGR02937
RNA polymerase sigma factor, sigma-70 family; This model encompasses all varieties of the ...
306-534 2.00e-18

RNA polymerase sigma factor, sigma-70 family; This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.


Pssm-ID: 274357 [Multi-domain]  Cd Length: 158  Bit Score: 82.40  E-value: 2.00e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647   306 SSREKLITANLRLVVHIAKQYQNRGLNFQDLLQEGSMGLMKSVEKFKPQSgcRFATYAYWWIRQSIRKSIFQNSRtirlp 385
Cdd:TIGR02937   1 EAFEELYERYLPLVYRYARRYLGDDADAEDLVQEAFLKLLEALDRFDPEG--SFKAWLFRIARNLILDYLRRKRR----- 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647   386 envymllgkvsearktcvqegnyrpskeelaghvgvstekldkllyntrtplsmqqpiwsDQDTTFQEITPDSGIETPTM 465
Cdd:TIGR02937  74 ------------------------------------------------------------LRRELDLLEELLDSDPSPEE 93
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16604647   466 SVGKQLMRNHVRNLLNVLSPKERRIIKLRFgidgGKQRSLSEIGEIYGLSKERVRQLESRALYRLKQNM 534
Cdd:TIGR02937  94 ELEQEEEREALREALEKLPEREREVLVLRY----LEGLSYKEIAEILGISVGTVKRRLKRARKKLRELL 158
PRK08301 PRK08301
RNA polymerase sporulation sigma factor SigE;
306-535 1.90e-17

RNA polymerase sporulation sigma factor SigE;


Pssm-ID: 236228 [Multi-domain]  Cd Length: 234  Bit Score: 81.83  E-value: 1.90e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  306 SSREKLITANLRLVVHIAKQYQNRGLNFQDLLQEGSMGLMKSVEKFKPQSGCRFATYAywwirqsirksifqnSRTIrlp 385
Cdd:PRK08301  52 AVRSLLIERNLRLVVYIARKFENTGINIEDLISIGTIGLIKAVNTFNPEKKIKLATYA---------------SRCI--- 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  386 EN-VYMLLgkvseaRktcvqegnyRPSKeelaghvgvstekldkllynTRTPLSMQQPIWSDQD-----------TTFQE 453
Cdd:PRK08301 114 ENeILMYL------R---------RNNK--------------------VKAEVSFDEPLNIDWDgnelllsdvlgTDNDI 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  454 ITPDsgIETptmSVGKQLMrnhvRNLLNVLSPKERRIIKLRFGIDGGKQRSLSEIGEIYGLSKERVRQLESRALYRLKQN 533
Cdd:PRK08301 159 IYKD--IED---EVDRKLL----KKALKKLSDREKQIMELRFGLNGGEEKTQKEVADMLGISQSYISRLEKRIIKRLKKE 229

                 ..
gi 16604647  534 MN 535
Cdd:PRK08301 230 IN 231
PRK05911 PRK05911
RNA polymerase sigma factor sigma-28; Reviewed
308-536 2.25e-17

RNA polymerase sigma factor sigma-28; Reviewed


Pssm-ID: 235644 [Multi-domain]  Cd Length: 257  Bit Score: 81.97  E-value: 2.25e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  308 REKLITANLRLVVHIAKQYQN---RGLNFQDLLQEGSMGLMKSVEKFKPQSGCRFATYAYWWIRQSIRKSIFQNSrtiRL 384
Cdd:PRK05911  25 RDVLIEFYLPLVKNVAHRLISgmpSHVKTEDLYASGVEGLVRAVERFDPEKSRRFEGYALFLIKAAIIDDLRKQD---WV 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  385 PENVYMLLGKVSEARKTCVQEGNYRPSKEELAGHVGVSTEKLDKLLYNTRTPLSM----QQPIWSDQDT--TFQEITPDS 458
Cdd:PRK05911 102 PRSVHQKANKLADAMDSLRQSLGKEPTDGELCEYLNISQQELSGWFSSARPALILslneEFPCQSDDEAglALEERIADE 181
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16604647  459 GIETPTMSVGKQLMRNHVRNLLNVLSPKERRIIKLRFgidgGKQRSLSEIGEIYGLSKERVRQLESRALYRLKQNMNS 536
Cdd:PRK05911 182 RAETGYDVVDKKEFSSILAEAILALEEKERKVMALYY----YEELVLKEIGKILGVSESRVSQIHSKALLKLRATLSA 255
PRK07122 PRK07122
RNA polymerase sigma factor SigF; Reviewed
296-534 4.00e-17

RNA polymerase sigma factor SigF; Reviewed


Pssm-ID: 168831 [Multi-domain]  Cd Length: 264  Bit Score: 81.36  E-value: 4.00e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  296 VLKSDIHRGRSSREKLITANLRLVVHIAKQYQNRGLNFQDLLQEGSMGLMKSVEKFKPQSGCRFATYAYWWIRQSIRKSI 375
Cdd:PRK07122  30 GLPAGSPEFQRQRDRIVTRCLPLADHIARRFDGRGEPRDDLVQVARVGLVNAVNRFDVETGSDFVSFAVPTIMGEVRRHF 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  376 FQNSRTIRLPENVYMLLGKVSEARKTCVQEGNYRPSKEELAGHVGVSTEKLDKLL-----YNTrtpLSMQQPIWSDQDTT 450
Cdd:PRK07122 110 RDNSWSVKVPRRLKELHLRLGRATAELSQRLGRAPTASELAAELGMDREEVVEGLvagsaYNT---LSIDSGGGSGDDDA 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  451 fQEITPDSGIETPTMSVGKQlmRNHVRNLLNVLSPKERRIIKLRFgIDGGKQrslSEIGEIYGLSKERVRQLESRALYRL 530
Cdd:PRK07122 187 -RAIADTLGDVDAGLDQIEN--REALRPLLAALPERERTVLVLRF-FESMTQ---TQIAERVGISQMHVSRLLAKTLARL 259

                 ....
gi 16604647  531 KQNM 534
Cdd:PRK07122 260 RDQL 263
Sigma70_r3 pfam04539
Sigma-70 region 3; Region 3 forms a discrete compact three helical domain within the ...
390-467 1.29e-16

Sigma-70 region 3; Region 3 forms a discrete compact three helical domain within the sigma-factor. Region is not normally involved in the recognition of promoter DNA, but as some specific bacterial promoters containing an extended -10 promoter element, residues within region 3 play an important role. Region 3 primarily is involved in binding the core RNA polymerase in the holoenzyme.


Pssm-ID: 427997 [Multi-domain]  Cd Length: 78  Bit Score: 74.56  E-value: 1.29e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16604647   390 MLLGKVSEARKTCVQEGNYRPSKEELAGHVGVSTEKLDKLLYNTRTPLSMQQPIWSDQDTTFQEITPDSGIETPTMSV 467
Cdd:pfam04539   1 ELLNKIKRAQRELEQELGREPTPEEIAEELGLSPEKVREVLEAAREPVSLDTPVGEEEDGELGDLLEDDDIESPEEAV 78
PRK07408 PRK07408
RNA polymerase sigma factor SigF; Reviewed
308-536 1.07e-15

RNA polymerase sigma factor SigF; Reviewed


Pssm-ID: 180965 [Multi-domain]  Cd Length: 256  Bit Score: 76.88  E-value: 1.07e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  308 REKLITANLRLVVHIAKQYQNR-GLNFQDLLQEGSMGLMKSVEKFKPQSGCRFATYAYWWIRQSIRKSIFQNSRTIRLPE 386
Cdd:PRK07408  27 RNQLVELNLGLVRKEAHRWSNQcSEPYEDLVQVGSLGLIRAIERFDPSKGHAFSSFAIPYIRGEIQHYLRDKSPTVRIPR 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  387 NVYMLLGKVSEARKTCVQEGNYRPSKEELAGHVGVSTEKLD--KLLYNTRTPLSMQQPIWSDQD--TTFQEITPDSGIEt 462
Cdd:PRK07408 107 RWQELQRQAKKVRQELRQELGRQPTDQEIAQALDISLEEWQeiKLALQNRTPLSLDAPVNQDEDgsTSLGDLLPDPRYR- 185
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16604647  463 ptmsvGKQLM---RNHVRNLLNVLSPKERRIIKLRFgidgGKQRSLSEIGEIYGLSKERV-RQLEsRALYRLKQNMNS 536
Cdd:PRK07408 186 -----SFQLAqedRIRLQQALAQLEERTREVLEFVF----LHDLTQKEAAERLGISPVTVsRRVK-KGLDQLKKLLQP 253
PRK06288 PRK06288
RNA polymerase sigma factor WhiG; Reviewed
308-531 1.15e-14

RNA polymerase sigma factor WhiG; Reviewed


Pssm-ID: 235770 [Multi-domain]  Cd Length: 268  Bit Score: 74.34  E-value: 1.15e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  308 REKLITANLRLVVHIAKQY-----QNrgLNFQDLLQEGSMGLMKSVEKFKPQSGCRFATYAYwwirQSIRKSIFQNSRTI 382
Cdd:PRK06288  33 REYLILKYSPLVKYVAGRIavgmpQN--VEFDDLVSYGVFGLIDAIEKFDPEREIKFKTYAV----TRIRGAIFDELRSI 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  383 -RLPENVYMLLGKVSEARKTCVQEGNYRPSKEELAGHVGVSTEKLDKLL--YNTRTPLSMQQPIWSDQDT---TFQEITP 456
Cdd:PRK06288 107 dWIPRSVRQKARQIERAIAMLEARLGRTPSDEEIADELGISLEEYNSLLskLSGTSVVSLNDLWFGGDEGdevSLMDTLE 186
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16604647  457 DSGIETPTMSVGKQLMRNHVRNLLNVLSPKERRIIKLRFGIDggkqRSLSEIGEIYGLSKERVRQLESRALYRLK 531
Cdd:PRK06288 187 SPAALNPDEIAEREEIKRVIVEAIKTLPEREKKVLILYYYED----LTLKEIGKVLGVTESRISQLHTKAVLQLR 257
PRK07670 PRK07670
FliA/WhiG family RNA polymerase sigma factor;
334-532 3.33e-14

FliA/WhiG family RNA polymerase sigma factor;


Pssm-ID: 181075 [Multi-domain]  Cd Length: 251  Bit Score: 72.38  E-value: 3.33e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  334 QDLLQEGSMGLMKSVEKFKPQSGCRFATYAYWwirqSIRKSIFQNSRTI-RLPENVYMLLGKVSEARKTCVQEGNYRPSK 412
Cdd:PRK07670  53 DDLKSLGMLGLYDALEKFDPSRDLKFDTYASF----RIRGAIIDGLRKEdWLPRSMREKTKKVEAAIEKLEQRYMRNVTP 128
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  413 EELAGHVGVSTEKL-----DKLLYNTrtpLSM-QQPIWSDQDTTFQEITPDSGIETPTMSVGKQLMRNHVRNLLNVLSPK 486
Cdd:PRK07670 129 KEVAAELGMTEEEVeatmnEGFFANL---LSIdEKTHDQDDGENVSVTIRDDKTPTPEEKLLKEELIEELAEKIKQLSEK 205
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 16604647  487 ERRIIKLRFGidggKQRSLSEIGEIYGLSKERVRQLESRALYRLKQ 532
Cdd:PRK07670 206 EQLVISLFYK----EELTLTEIGQVLNLSTSRISQIHSKALFKLKK 247
Sigma70_r4 pfam04545
Sigma-70, region 4; Region 4 of sigma-70 like sigma-factors are involved in binding to the -35 ...
479-532 2.93e-13

Sigma-70, region 4; Region 4 of sigma-70 like sigma-factors are involved in binding to the -35 promoter element via a helix-turn-helix motif. Due to the way Pfam works, the threshold has been set artificially high to prevent overlaps with other helix-turn-helix families. Therefore there are many false negatives.


Pssm-ID: 461347 [Multi-domain]  Cd Length: 50  Bit Score: 63.99  E-value: 2.93e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 16604647   479 LLNVLSPKERRIIKLRFGidggKQRSLSEIGEIYGLSKERVRQLESRALYRLKQ 532
Cdd:pfam04545   1 ALASLPPRERQVLVLRYG----EGLTLEEIGERLGISRERVRQIEKRALRKLRK 50
PRK08583 PRK08583
RNA polymerase sigma factor SigB; Validated
309-532 5.94e-13

RNA polymerase sigma factor SigB; Validated


Pssm-ID: 236306 [Multi-domain]  Cd Length: 257  Bit Score: 68.95  E-value: 5.94e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  309 EKLITANLRLVVHIAKQYQNRGLNFQDLLQEGSMGLMKSVEKFKPQSGCRFATYAYWWIRQSIRKSIFQNSRTIRLPENV 388
Cdd:PRK08583  32 EKLVKHYKNLVESLAYKYSKGQSHHEDLVQVGMVGLLGAIRRYDPSFGRSFEAFAVPTIIGEIKRYLRDKTWSVHVPRRI 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  389 YMLLGKVSEARKTCVQEGNYRPSKEELAGHVGVSTEKLDKLL-----YNTrtpLSMQQPIWSDQD---TTFQEI--TPDS 458
Cdd:PRK08583 112 KELGPKIKKAVDELTTELQRSPKISEIADRLGVSEEEVLEAMemgksYQA---LSVDHSIEADSDgstVTLLDIvgQQED 188
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16604647  459 GIEtptmSVGKQLMrnhVRNLLNVLSPKERRIIKLRFgIDGGKQRslsEIGEIYGLSKERVRQLESRALYRLKQ 532
Cdd:PRK08583 189 GYE----LTEQRMI---LEKILPVLSDREKSIIQCTF-IENLSQK---ETGERLGISQMHVSRLQRQAIKKLRE 251
fliA PRK06986
flagellar biosynthesis sigma factor; Validated
304-535 2.20e-12

flagellar biosynthesis sigma factor; Validated


Pssm-ID: 235901 [Multi-domain]  Cd Length: 236  Bit Score: 66.79  E-value: 2.20e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  304 GRSSREKLITANLRLVVHIAKQYQNR---GLNFQDLLQEGSMGLMKSVEKFKPQSGCRFATYAywwiRQSIRKSIFQNSR 380
Cdd:PRK06986   6 GKMDQDELVEQYAPLVKRIALRLKARlpaSVDLDDLIQAGMIGLLEAARRYDGEQGASFETYA----GQRIRGAMLDELR 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  381 tiRL---PENVYMLLGKVSEARKTCVQEGNYRPSKEELAGHVGVSTEKLDKLLYNTRTPLSMqqPI--WSDQDTTFQEIT 455
Cdd:PRK06986  82 --SLdwvPRSVRRNAREVAQAIRQLEQELGREPTDTEVAEKLGLSLEEYREMLLDTNISQLF--SIdeLRGEHGDSILVT 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  456 PDSGIETPTMSVGKQLMRNHVRNLLNVLSPKERRIIKLRFgidggkQR--SLSEIGEIYGLSKERVRQLESRALYRLKQN 533
Cdd:PRK06986 158 EDHQDEDPLQQLEDEELREALVEAIESLPEREQLVLSLYY------QEelNLKEIGAVLGVSESRVSQIHSQAIKRLRAR 231

                 ..
gi 16604647  534 MN 535
Cdd:PRK06986 232 LG 233
Sigma70_r4 cd06171
Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in ...
473-531 4.85e-11

Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or plastid core RNA polymerase to specific promoter elements located upstream of transcription initiation points. The SR4 of Ec sigma70 and other essential primary SFs contact promoter sequences located 35 base-pairs upstream of the initiation point, recognizing a 6-base-pair -35 consensus TTGACA. Sigma70 related SFs also include SFs which are dispensable for bacterial cell growth for example Ec sigmaS, SFs which activate regulons in response to a specific signal for example heat-shock Ec sigmaH, and a group of SFs which includes the extracytoplasmic function (ECF) SFs and is typified by Ec sigmaE which contains SR2 and -4 only. ECF SFs direct the transcription of genes that regulate various responses including periplasmic stress and pathogenesis. Ec sigmaE SR4 also contacts the -35 element, but recognizes a different consensus (a 7-base-pair GGAACTT). Plant SFs recognize sigma70 type promoters and direct transcription of the major plastid RNA polymerase, plastid-encoded RNA polymerase (PEP).


Pssm-ID: 100119 [Multi-domain]  Cd Length: 55  Bit Score: 57.88  E-value: 4.85e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 16604647 473 RNHVRNLLNVLSPKERRIIKLRFGidggKQRSLSEIGEIYGLSKERVRQLESRALYRLK 531
Cdd:cd06171   1 RERLEEALDKLPEREREVILLRFG----EGLSYEEIAEILGISRSTVRQRLHRALKKLR 55
RpoE COG1595
DNA-directed RNA polymerase specialized sigma subunit, sigma24 family [Transcription]; ...
461-539 3.50e-06

DNA-directed RNA polymerase specialized sigma subunit, sigma24 family [Transcription]; DNA-directed RNA polymerase specialized sigma subunit, sigma24 family is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 441203 [Multi-domain]  Cd Length: 181  Bit Score: 47.68  E-value: 3.50e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16604647 461 ETPTMSVGKQLMRNHVRNLLNVLSPKERRIIKLRFgIDGgkqRSLSEIGEIYGLSKERVRQLESRALYRLKQNMNSHGL 539
Cdd:COG1595 106 ADPEEALEAEELLEALLAALERLPPRQREVLVLRY-LEG---LSYAEIAEILGISEGTVKSRLSRARKKLREALEEEGA 180
PRK08295 PRK08295
RNA polymerase sporulation sigma factor SigH;
309-510 1.72e-04

RNA polymerase sporulation sigma factor SigH;


Pssm-ID: 181361 [Multi-domain]  Cd Length: 208  Bit Score: 42.97  E-value: 1.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  309 EKLITANLRLVVHIAKQYQNRGLNFQDLLQEGSMGLMKSVEKFKPQSGCRFATYAYWWIRQSIRKSIFQNSRTIRLPENV 388
Cdd:PRK08295  27 EYLIEKYKNFVRAKARSYFLIGADREDIVQEGMIGLYKAIRDYDKDKLSSFKSFAELCITRQIITAIKTANRQKHIPLNS 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16604647  389 YmllgkVSearktcvqegnyrpskeelaghvgvstekLDKLLYNtrtplsmqqpiwSDQDTTFQEITPDSGIETP-TMSV 467
Cdd:PRK08295 107 Y-----VS-----------------------------LDKPIYD------------EESDRTLLDVISEAKVTDPeELII 140
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 16604647  468 GKQLMRNHVRNLLNVLSPKERRIIKLRfgIDGgkqRSLSEIGE 510
Cdd:PRK08295 141 SKEELEDIEEKIEELLSELEKEVLELY--LDG---KSYQEIAE 178
PRK09648 PRK09648
RNA polymerase sigma factor ShbA;
473-532 7.20e-03

RNA polymerase sigma factor ShbA;


Pssm-ID: 236607 [Multi-domain]  Cd Length: 189  Bit Score: 38.03  E-value: 7.20e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16604647  473 RNHVRNLLNVLSPKERRIIKLRF--GIdggkqrSLSEIGEIYGLSKERVRQLESRALYRLKQ 532
Cdd:PRK09648 130 SNRMRELLDTLPEKQREILILRVvvGL------SAEETAEAVGSTPGAVRVAQHRALARLRA 185
Sigma70_r4_2 pfam08281
Sigma-70, region 4; Region 4 of sigma-70 like sigma-factors are involved in binding to the -35 ...
476-530 9.79e-03

Sigma-70, region 4; Region 4 of sigma-70 like sigma-factors are involved in binding to the -35 promoter element via a helix-turn-helix motif.


Pssm-ID: 400535 [Multi-domain]  Cd Length: 54  Bit Score: 34.35  E-value: 9.79e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 16604647   476 VRNLLNVLSPKERRIIKLRFgIDGgkqRSLSEIGEIYGLSKERVRQLESRALYRL 530
Cdd:pfam08281   4 LLRALEELPPRQREVFLLRY-LEG---LSYAEIAELLGISEGTVKSRLSRARKKL 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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