|
Name |
Accession |
Description |
Interval |
E-value |
| PRK07561 |
PRK07561 |
DNA topoisomerase I subunit omega; Validated |
2-849 |
0e+00 |
|
DNA topoisomerase I subunit omega; Validated
Pssm-ID: 236048 [Multi-domain] Cd Length: 859 Bit Score: 1543.98 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 2 GKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADststktakkpkkderGALVNRMGVDPWHNWDA 81
Cdd:PRK07561 1 GKSLVIVESPAKAKTINKYLGSDYVVKASVGHIRDLPTSASSVPAKEK---------------GALWARMGVDPDHDFEA 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 82 HYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEQPGELNINR 161
Cdd:PRK07561 66 LYEVLPGKEKVVSELKKAAKDADELYLATDPDREGEAIAWHLLEVLGGDDVPVKRVVFNEITKNAIQEAFENPRELDINL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 162 VNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGEALPLQVTHQ 241
Cdd:PRK07561 146 VNAQQARRFLDRLVGYMVSPLLWKKIARGLSAGRVQSVAVRLIVEREREIEAFVPEEYWDIHADLTTPRGDAFEARLTHL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 242 NDKPFRPV---NREQTLAAVSLLEKARYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYIT 318
Cdd:PRK07561 226 DGKKFAPVdllNEAQAEAAVAALEGARYSVASVEDKPTTRKPSAPFTTSTLQQEASRKLGFSVKKTMRIAQRLYEAGYIT 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 319 YMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASK-ENSQEAHEAIRPSDVAVMAESLKDMEADAQKLYQLIWRQ 397
Cdd:PRK07561 306 YMRTDSTNLSQEAINAARGYIGDNYGKKYLPEKPRQYSSKaKNAQEAHEAIRPSDVFRTPDQLKGLEGDAQRLYELIWKR 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 398 FVACQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKG---DEDRTLPAVNKGDALTLLELTPAQHFTKPP 474
Cdd:PRK07561 386 FVASQMAPARYDSTTVTIAAGDAELRATGRVLRFDGFLKVYVEGRDDaldDEDRRLPALKVGDALTLEKLDPTQHFTKPP 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 475 ARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVA 554
Cdd:PRK07561 466 ARYSEASLVKELEKLGIGRPSTYASIISTIQDRGYVRLENRRFYPEKMGRIVTDRLEEFFPRLVDYDFTARMEEELDDIA 545
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 555 NHQAEWKAVLDNFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALspKERCKTTI 634
Cdd:PRK07561 546 NGEADWKPVLDDFYKDFSQQLEKAEELREEGGMRPNQMVITDRDCPTCGRGMGIRTGKTGVFLGCSGYAL--KERCKTTR 623
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 635 NLVPENEVLNVLEGDDAETNALRAKrrcQKCGTAM-------DSYLI----DPKRKLHVC-GNNPTCDGYEIEEGEFRIK 702
Cdd:PRK07561 624 NLTPEEETLNVLEGEDAETRALGAD---PECGTAMvlrsgrfGPYVQegegDKPRRLSLPkGNNPECVGLEIALGLLSLP 700
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 703 gydGPIVECEKCGSEMHLKMGRFGKYMAC--TNDECKNTRKILRNGEVAP---------PKEDPVPLPELPCEKSDAYFV 771
Cdd:PRK07561 701 ---RPVGEHPECGSEIQAKIGRFGPYVKCggTYASLKNTRKVLTIGLNRAvellaepkrPKEDPVPLPELGCPKSGAPFV 777
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 772 LRDGAAGIFL----AANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKDGK 847
Cdd:PRK07561 778 LRDGRYGPYVkhgkANATLPKGRETRAPTVEEALELLAEKPEKLRYLADAPAKDPAGKKAAVKFSRKTKQQYVASEKDGK 857
|
..
gi 16420244 848 AT 849
Cdd:PRK07561 858 AT 859
|
|
| topA_bact |
TIGR01051 |
DNA topoisomerase I, bacterial; This model describes DNA topoisomerase I among the members of ... |
5-637 |
0e+00 |
|
DNA topoisomerase I, bacterial; This model describes DNA topoisomerase I among the members of bacteria. DNA topoisomerase I transiently cleaves one DNA strand and thus relaxes negatively supercoiled DNA during replication, transcription and recombination events. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273416 [Multi-domain] Cd Length: 610 Bit Score: 939.50 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 5 LVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSgsaakksadststktakkpkkdergalvnRMGVDPWHNWDAHYE 84
Cdd:TIGR01051 1 LVIVESPAKAKTIKKYLGDEYEVEASMGHIRDLPKS-----------------------------RLGVDIEKDFEPEYV 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 85 VLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEQPGELNINRVNA 164
Cdd:TIGR01051 52 VSKGKKKVVKELKTLAKKADEVYLATDPDREGEAIAWHLAEVLKPKDPVYKRIVFNEITKKAIRAALKNPREIDMNLVNA 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 165 QQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDAnTTTPSGEALPLQVTHQNDK 244
Cdd:TIGR01051 132 QQARRILDRLVGYTLSPLLWKKVAKGLSAGRVQSVALRLIVDREREIKRFVPEEYWTIDA-TFQKGEETFEALLTEVNGK 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 245 PFRPV---NREQTLAAVSLLEKARYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEA------- 314
Cdd:TIGR01051 211 KLKAGsdlDEAEATALKEQLKGEELVVEEIEKKPKKSRPPPPFTTSTLQQEASRKLGFSAKKTMMIAQRLYEGvstgdgt 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 315 -GYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKE-NSQEAHEAIRPSDVAVMAESLKD-MEADAQKLY 391
Cdd:TIGR01051 291 iGLITYMRTDSTRLSNQAVNEARNLIDKNYGKEYLGPKPKRYKSKEkNAQEAHEAIRPTSVFRTPEELKDyLKRDEFRLY 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 392 QLIWRQFVACQMTPAQYDSTTLTVGA--GEFRLKARGRILRFDGWTKVMPALRKG---DEDRTLPAVNKGDALTLLELTP 466
Cdd:TIGR01051 371 ELIWKRFVASQMADARYDSTSVRLTNedGEYVFKATGRKLIFDGYYKVYVEGSDDpleEKDRILPPLKEGDAVKLVEVKP 450
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 467 AQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQM 546
Cdd:TIGR01051 451 NQHFTQPPARYTEASLVKELEELGIGRPSTYASIISTIQDRGYVKKENKRLYPTELGFAVTDLLEKHFGDVVDYDFTAKM 530
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 547 EDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEKdpeeggMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYalsp 626
Cdd:TIGR01051 531 EKDLDEIAEGKAEWKPVLKNFYTGFSSKVKKLRN------MRIIVDFKTSQDCPLCGRPMVVKLGKYGPFLACSNF---- 600
|
650
....*....|.
gi 16420244 627 kERCKTTINLV 637
Cdd:TIGR01051 601 -PECKYTKSIV 610
|
|
| PRK06599 |
PRK06599 |
DNA topoisomerase I; Validated |
1-742 |
0e+00 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235840 [Multi-domain] Cd Length: 675 Bit Score: 888.05 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 1 MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPtsgsaaKKSadststktakkpkkdergalvnrMGVDPWHNWD 80
Cdd:PRK06599 1 MAKKLVIVESPAKAKTIKKYLGKDYKVLASFGHVRDLP------KKK-----------------------GGVDPDNDFA 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 81 AHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIG---GDDARYSRVVFNEITKNAIRQAFEQPGEL 157
Cdd:PRK06599 52 PKYEIIEGKEKVVDALKKAAKKADAVYLATDPDREGEAIAWHIAEVLKeakLKDKNVKRVVFNEITKKAVQEAIENPRDI 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 158 NINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGEALPLQ 237
Cdd:PRK06599 132 DMDLVDAQQARRALDYLVGFKLSPLLWKKVRRGLSAGRVQSVALRLICEREDEIEAFIPQEYWTIEADLATSNGEPFTAK 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 238 VTHQNDK---PFRPVNREQTLAAVSLLEKARYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEA 314
Cdd:PRK06599 212 LVEVNGKkleKFSITNEEQAKALVKALEGQAYTVDKIEKKERKRNPPPPFITSTLQQEASRKLGFSAKKTMRIAQKLYEG 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 315 --------GYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASK-ENSQEAHEAIRPSDVAVMAESLKD-ME 384
Cdd:PRK06599 292 idlgegtvGLITYMRTDSVRLSNEALDEARKYITKKYGKEYLPAKPRVYKKKsKNAQEAHEAIRPTSINRTPESLKPyLT 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 385 ADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGA--GEFRLKARGRILRFDGWTKVMPA---LRKGDEDRTLPAVNKGDAL 459
Cdd:PRK06599 372 PDQFKLYELIWKRTVASQMAPAILDQTSVDIASenGKYVFRATGSVILFPGFLKVYGEskdDEEEDDEKLLPPLKEGEKL 451
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 460 TLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMN 539
Cdd:PRK06599 452 KLDELLPEQHFTEPPPRYSEASLVKKLEEYGIGRPSTYASIISTLQDREYVELEKKRFIPTDLGRIVNDFLVEHFPKYVD 531
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 540 YDFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEKDPEEGGMRPNQmvlTSIDCPTC-GRKMGIRTASTGVFLG 618
Cdd:PRK06599 532 YDFTAGLEDELDEIAEGKKDWKPVLREFWEPFISNLEKVEEDVRTEKVTQEE---TDETCPKCgGGPLVLKLGKNGKFLG 608
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 619 CSGYalsPKerCKTTINLVPENEVlnvlegddaetnalrakrrcqkcgtamdsylidpkrklhvcgnnptcdgyEIEEGE 698
Cdd:PRK06599 609 CSGY---PE--CKYTKNITRDEDE--------------------------------------------------PIEEEE 633
|
730 740 750 760
....*....|....*....|....*....|....*....|....*
gi 16420244 699 FRikgydgPIVECEKCGSEMHLKMGRFGKYMACTND-ECKNTRKI 742
Cdd:PRK06599 634 IV------EEEKCPKCGGPLVLKKGRYGKFLACSGYpECKHIKPL 672
|
|
| TopA |
COG0550 |
DNA topoisomerase IA [Replication, recombination and repair]; |
3-576 |
0e+00 |
|
DNA topoisomerase IA [Replication, recombination and repair];
Pssm-ID: 440316 [Multi-domain] Cd Length: 541 Bit Score: 864.79 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 3 KALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGsaakksadststktakkpkkdergalvnrMGVDPWHNWDAH 82
Cdd:COG0550 1 KKLVIVESPAKAKTIAKYLGKDYVVTASVGHLRDLPKPE-----------------------------LDVDVENDFEPK 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 83 YEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGgDDARYSRVVFNEITKNAIRQAFEQPGELNINRV 162
Cdd:COG0550 52 YEVIPGKKKQVKELKKLAKKADEVILATDPDREGEAIAWHLLELLG-DKKPVKRVVFNEITKKAIKEAFKNPRDIDMNLV 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 163 NAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPsGEALPLQVTHQN 242
Cdd:COG0550 131 DAQQARRILDRLVGYNLSPLLWKKVKRGLSAGRVQSPALRLIVEREREIEAFVPEEYWTIEATFKTG-GGEFTAKLVKID 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 243 DKpfRPVNREQTLAAVSLLEKARYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRT 322
Cdd:COG0550 210 GK--KILDEEEAEAILAALKGKTFTVTSVEKKPKKRNPPPPFTTSTLQQEASRKLGFSAKKTMSIAQRLYEVGLITYMRT 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 323 DSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVAVMAESLkdmEADAQKLYQLIWRQFVACQ 402
Cdd:COG0550 288 DSVRLSEDAVAAAREYIEALYGKEYLPEKPRVYKTSKNAQEAHEAIRPTGVTRTPESL---SGDEFKLYDLIWKRFLASQ 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 403 MTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALR---KGDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSE 479
Cdd:COG0550 365 MPPAEYETTTVTIEVGGEEFRASGKVIKFPGFLKVYGEGKddeEEEEEKRLPPLKEGEKLKLKKIEPEQHFTKPPPRYTE 444
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 480 ASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAE 559
Cdd:COG0550 445 ASLVKAMEELGIGRPSTYASIIETLQDRGYVEREGKRLVPTELGFIVIDLLEEHFPDLVDYEFTAKMEEKLDEIAEGKLD 524
|
570
....*....|....*..
gi 16420244 560 WKAVLDNFFSDFTQQLD 576
Cdd:COG0550 525 WKDVLEEFYKPFKELVE 541
|
|
| PRK06319 |
PRK06319 |
DNA topoisomerase I/SWI domain fusion protein; Validated |
1-787 |
0e+00 |
|
DNA topoisomerase I/SWI domain fusion protein; Validated
Pssm-ID: 235778 [Multi-domain] Cd Length: 860 Bit Score: 605.66 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 1 MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGsaakksadststktakkpkkdergalvnrMGVDPWHNWD 80
Cdd:PRK06319 1 MKKSLIIVESPAKIKTLQKLLGEGFIFASSLGHIVDLPAKE-----------------------------FGIDIENDFE 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 81 AHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGgDDARYSRVVFNEITKNAIRQAFEQPGELNIN 160
Cdd:PRK06319 52 PDYQILPDKEEVINKICKLAKKCDVVYLSPDPDREGEAIAWHIANQLP-KNTKIQRISFNAITKGAVTEALKHPREIDMA 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 161 RVNAQQARRFMDRVVGYMVSPLLWKKIAR--GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGEALPLQV 238
Cdd:PRK06319 131 LVNAQQARRLLDRIVGYKISPILSRKLQRrsGVSAGRVQSVALKLVVDREKAIEAFVPVEYWNIRVHLKDPKTQKTFWAH 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 239 THQND-----------KPFRPV----NREQTLAAVSLLEKARYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKK 303
Cdd:PRK06319 211 LYSVDgkkwekeipegKTEDEVllinSKEKADHIVELLESATYTVTRVESKEKRRNAYPPFITSTLQQEASRHFRFSSSR 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 304 TMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVA 374
Cdd:PRK06319 291 TMNIAQTLYEGvdldsegatGLITYMRTDSVRTDPEALKQVRKYIEGTFGKEFLPSSPNVYTTKKMAQDAHEAIRPTDIT 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 375 VMAESLKDMEADAQ-KLYQLIWRQFVACQMTPAQYDSTTLTVGAG-EFRLKARGRILRFDGWTKVMPALR----KGDEDR 448
Cdd:PRK06319 371 LTPEKLRSKLTEDQyKLYSLIWKRFVASQMIPAIYDTLAIRITTNkGIDLRATGSLLKFKGFLAVYEEKRddegDEEENI 450
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 449 TLPAVNKGDALTLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTD 528
Cdd:PRK06319 451 HLPKLHEQDVLTKEELSAEQAFTKPLPRFTEASLVKELEKSGIGRPSTYATIMNKIQSREYTLKENQRLRPTELGKIISQ 530
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 529 RLEENFRELMNYDFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEKDpeegGMRPNqmVLTSIDCPTC-GRKMG 607
Cdd:PRK06319 531 FLETNFPRIMDIGFTALMEDELELIADNKKPWKLLLQEFWELFLPVVVTAEKE----AFIPR--IVTEIDCPKChKGKLV 604
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 608 IRTASTGVFLGCSGYalspkerckttinlvpenevlnvlegddaetnalrakrrcqkcgtamdsylidpkrklhvcgnnP 687
Cdd:PRK06319 605 KIWAKNRYFYGCSEY----------------------------------------------------------------P 620
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 688 TCDgYEIEEGE--FRIKGY------DGPiveCEKCGSEMHLKMGRFGKYMACTN-DECKNTRKILRNGEVAPPKEDPVPL 758
Cdd:PRK06319 621 ECD-YKTSEEEltFNKEDYaedtpwDSP---CPLCGGEMKVRHGRFGTFLGCENyPECRGIINIHKKGEEGIEPEETVPC 696
|
810 820
....*....|....*....|....*....
gi 16420244 759 PELPCekSDAYFVLRDGAAGIFLAANTFP 787
Cdd:PRK06319 697 PAIGC--TGHIVKRRSRFNKMFYSCSEYP 723
|
|
| PRK08780 |
PRK08780 |
DNA topoisomerase I; Provisional |
1-616 |
0e+00 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 181555 [Multi-domain] Cd Length: 780 Bit Score: 566.70 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 1 MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLptsgsaakksadststktakKPKKderGAlvnrmgVDPWHNWD 80
Cdd:PRK08780 1 MSKHLVIVESPAKAKTINKYLGKDFTVLASYGHVRDL--------------------VPKE---GA------VDPENGFA 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 81 AHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGG----DDARYSRVVFNEITKNAIRQAFEQPGE 156
Cdd:PRK08780 52 MRYDLIDKNEKHVEAIAKAAKSADDLYLATDPDREGEAISWHLAEILKErgllKDKPMQRVVFTEITPRAIKEAMAKPRD 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 157 LNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSgEALPL 236
Cdd:PRK08780 132 IASDLVDAQQARRALDYLVGFNLSPLLWRKIQRGLSAGRVQSPALRMIVEREEEIEAFIAREYWSIEADCAHPS-QPFNA 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 237 QVTH---QNDKPFRPVNREQTLAAVSLLEKA---RYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQR 310
Cdd:PRK08780 211 KLIKldgQKFEQFTITDGDTAEAARLRIQQAaqgTLHVTDVESKERKRNPAPPFTTSTLQQEASRKLGFTTRRTMQVAQK 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 311 LYEA---------GYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASK-ENSQEAHEAIRPSDVAVMAESL 380
Cdd:PRK08780 291 LYEGvdlgdegsvGLITYMRTDSVNLSQDALAEIRDVIARDYGTASLPDQPNTYKTKsKNAQEAHEAVRPTSALRTPAQV 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 381 KD-MEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAG-EFRLKARGRILRFDGWTKVMPALR------KGDEDRTLPA 452
Cdd:PRK08780 371 ARfLSDDQRRLYELIWKRAVACQMIPATLNTVSVDLAAGsEHVFRATGSTVVVPGFLAVYEEGKddksaeDEDEGRKLPP 450
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 453 VNKGDALTLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEE 532
Cdd:PRK08780 451 MKEGDNVPLERIRAEQHFTEPPPRYTEASLVKALEEYGIGRPSTYASIISTLQFRKYVEMEGRRFRPTDVGRAVNKFLTG 530
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 533 NFRELMNYDFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEK--DPEEGGmrpnQMVLTSIDcPTCGRKMGIRT 610
Cdd:PRK08780 531 HFTRYVDYDFTARLEDDLDAVSRGEKEWIPLMEKFWGPFKELVEEKKDsvDRTEAG----QVRELGTD-PKSGKPVSVRI 605
|
....*.
gi 16420244 611 ASTGVF 616
Cdd:PRK08780 606 GRFGPM 611
|
|
| TOP1Ac |
cd00186 |
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ... |
159-575 |
8.16e-171 |
|
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.
Pssm-ID: 238110 [Multi-domain] Cd Length: 381 Bit Score: 499.44 E-value: 8.16e-171
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 159 INRVNAQQARRFMDRVVGYMVSPLLWKKIAR--GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDAntttpsgealpl 236
Cdd:cd00186 1 ENLVNAQLARRILDRLVGFNLSRLLTKKLRRkgVLSAGRVQSPTLGLIVEREREIKAFVPEDYWEIKE------------ 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 237 qvthqndkpfrpvnreqtlaavsllekarYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGY 316
Cdd:cd00186 69 -----------------------------AVVVSVEKKEKKKNPPPPFTTSTLQQEASSKLGFSAKKTMQIAQKLYEAGL 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 317 ITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQ----YASKENSQEAHEAIRPSDVAVMAESLKDMEADAQKLYQ 392
Cdd:cd00186 120 ITYPRTDSTRLSEEAILEAREYIQAIYGKEYLYPAPLLgrrnPKRGKKEQGAHEAIRPTKVAPTPELEANLSEDEFKLYE 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 393 LIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKGDEDrTLPAVNKGDALTLLELTPAQHFTK 472
Cdd:cd00186 200 LIWRRFLASQMADAKYEETTVTLEIGGEKFKASGKVLLEDGWLEVYPEEKDDEEE-EPPPLKEGDELKLEEVELEEKETQ 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 473 PPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQ 552
Cdd:cd00186 279 PPPRYTEASLIKLMEKRGIGRPSTYASIIETLLDRGYVEKEKKKLIPTELGFAVIELLEKHFPELVDPEFTAKLEEKLDE 358
|
410 420
....*....|....*....|...
gi 16420244 553 VANHQAEWKAVLDNFFSDFTQQL 575
Cdd:cd00186 359 IAEGKKDYQEVLEEFYEEFKKIV 381
|
|
| Topoisom_bac |
pfam01131 |
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ... |
156-565 |
3.51e-158 |
|
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.
Pssm-ID: 426069 [Multi-domain] Cd Length: 410 Bit Score: 468.26 E-value: 3.51e-158
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 156 ELNINRVNAQQARRFMDRVVGYMVSPLLWKKI--ARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGEA 233
Cdd:pfam01131 1 EIDENLVDAQLARRELDWLIGFNLSRLLTLKLkgNKLLSAGRVQTPTLALIVEREREIENFVPEPYWTIEATLKDGGGVF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 234 lplqvTHQNDKPFRPVNREQTLAAVSLLEKARYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYE 313
Cdd:pfam01131 81 -----ANAKWKRGRIFDKEEAEAILEKLKKGTAVVTSVESKEKKKPPPLPFNTTTLQKEASRKLGFSAKKTMSIAQKLYE 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 314 -AGYITYMRTDSTNLSQDA-VNMVRGYIGDNFGKkYLPDNPNQYASK------ENSQ-EAHEAIRPSDVAVMAESLKDme 384
Cdd:pfam01131 156 kHGLITYPRTDSTYLSDDAtLKAILEYLTKNYGK-YLPYAPRLLKKTkgkltvGNAKvTAHEAIRPTGDIPVLPELSD-- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 385 aDAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKgDEDRTLPAVNKGDALTLLEL 464
Cdd:pfam01131 233 -DERKLYELIVRRFLASQMPPAVYETTTVVLEVGGEEFRASGKVILEDGWLKVYPYEKK-EDEEELPELKEGEELKVTQV 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 465 TPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLeENFRELMNYDFTA 544
Cdd:pfam01131 311 EVEEKKTKPPPRYTEASLIKAMEKAGIGTPATRATIIETLLERGYVERKKKSLVPTELGKALVEAL-EKFPDLVDPELTA 389
|
410 420
....*....|....*....|.
gi 16420244 545 QMEDSLDQVANHQAEWKAVLD 565
Cdd:pfam01131 390 ELEEKLDEIAEGKLDWKDVLA 410
|
|
| TOP1Ac |
smart00437 |
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, ... |
272-526 |
1.41e-118 |
|
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit
Pssm-ID: 214663 [Multi-domain] Cd Length: 259 Bit Score: 360.02 E-value: 1.41e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 272 EDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDN 351
Cdd:smart00437 1 EEKEKKKNPPPPFTTSTLQQEASRKLGFSAKKTMQIAQKLYEKGLITYPRTDSTRLSEEAVLEARNYIQKLYGKEYLDLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 352 -----PNQYASKENSQEAHEAIRPSDVAVMAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARG 426
Cdd:smart00437 81 vvllkPRKPRKGKKAQGAHEAIRPTKPIFTPELEKELSEDEFKLYELIWRRFLASQMPDAKYEETKVTIKIGGEKFKAKG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 427 RILRFDGWTKVMPALRKgDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQD 506
Cdd:smart00437 161 KTLLFDGWLKVYPEEKK-EEEIELPTLKKGDELKVEEVEVEEKETKPPARYTEASLIKLMEKRGIGRPSTYASIIETLLD 239
|
250 260
....*....|....*....|
gi 16420244 507 RGYVRVENRRFYAEKMGEIV 526
Cdd:smart00437 240 RGYVTKKKKKLIPTELGIAV 259
|
|
| PRK07219 |
PRK07219 |
DNA topoisomerase I; Validated |
73-793 |
1.37e-104 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235971 [Multi-domain] Cd Length: 822 Bit Score: 342.37 E-value: 1.37e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 73 VDPwhNW--DAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAI---AWHLREVIGGDDARysRVVFNEITKNAI 147
Cdd:PRK07219 68 VDP--AEliDADPVKKITKQNYINALKKLAKDADEIIIATDYDREGELIgkeAYHILREVCQVPVK--RARFSSLTKKEI 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 148 RQAFEQPGELNINRVNAQQARRFMDRVVGYMVSPLLW---KKIARG--LSAGRVQSVAVRLVVEREREIKAFVPEEFWEI 222
Cdd:PRK07219 144 RKAFENPDEIDFNLADAGEARQIIDLYWGAALTRFLSlsvRQLGRWdfLSVGRVQTPTLAFIVDREREIRAFDPEDYWKI 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 223 DAN-TTTPSGEALPLQVTHQNDKPFrpvNREQTLAAVSLLEKARYS-VLEREDKPTSSKPGAPFITSTLQQAASTRLGFG 300
Cdd:PRK07219 224 EALlDKEAQYFYRDLIGGHEAEKFW---DEEEAEEIYEKLKGAKEAtVSSVKKRERTISPPAPFNTTEFLREASKIFGIS 300
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 301 VKKTMMMAQRLYEAGYITYMRTDSTNLSQD------AVNMVRGYIGDNFGKKYLP-DNPNQYASKENSQeAHEAIRPSDV 373
Cdd:PRK07219 301 PKRAMEIAEKLYTAGYISYPRTDNTVYPDDldpkelLKKLSKKKEYGPYAESILEqENIKPTEGKKETT-DHPPIHPVDV 379
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 374 AvmaeSLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKgdEDRTLPAV 453
Cdd:PRK07219 380 P----KREELSDDEWKVYELIVRRFLATLADPAEWEYLKVELDVNGEIFKASGSRLVEEGWHEVYPYEKF--DEKELPDL 453
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 454 NKGDALTLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVrVENRRFYAEKMGEIVTDRLEEN 533
Cdd:PRK07219 454 EEGEKLKVNKIEIEAKETQPPKRYTQSSLIKEMEKRGLGTKATRHDIIEKLYKRGYV-IEGDPPRPTDLGIAVIEALEKY 532
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 534 FRELMNYDFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEKDPEE------GGMRPNQMVLTSI-DCPTCGRKM 606
Cdd:PRK07219 533 APEIVSEEMTAQLEADMQAIEDGKKKKEDVTEESREMLKEILSELKEKRKEigdhlaGSLKAENRSLKTIgKCPECGGDL 612
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 607 GIRTASTGV-FLGCSGYalspkERCKTTINLvPENEVLNVLEgddaetnalrakRRCQKCGTAMDSYLIDPKRKLHVCgn 685
Cdd:PRK07219 613 IIIRTDKGSrFVGCSGY-----PDCRNTFPL-PSTGRIKVLD------------EVCEKCGLPVIKILRGKQTFVVGC-- 672
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 686 nPTCDGYEIEEGEFRIKGydgpivECEKCGSEMHLKMGRFGKYMACTN-DECKNTRKILRNGEVAPPKEDpvplpelpCE 764
Cdd:PRK07219 673 -PDCEAEKEEEDPDEVIG------PCPKCGGELAIKQLKYGSFLGCTNyPKCKYTLPLPRRGKITVTDEK--------CP 737
|
730 740
....*....|....*....|....*....
gi 16420244 765 KSDAYFVLRDGAAGIFLAANTFPKSRETR 793
Cdd:PRK07219 738 ECGLPLLRVKGGFGDELGCCNNPKCNYTE 766
|
|
| TopG2 |
COG1110 |
Reverse gyrase [Replication, recombination and repair]; |
4-568 |
3.91e-86 |
|
Reverse gyrase [Replication, recombination and repair];
Pssm-ID: 440727 [Multi-domain] Cd Length: 1219 Bit Score: 298.81 E-value: 3.91e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 4 ALVIVESPAKAKTINKYLGN-----------------DYV--VKSSVGHIRDLPTSGsaakksadststktakkPKKDER 64
Cdd:COG1110 631 ALVIVESPNKARTIASFFGKpsrrrigglrvyevsigDYLllITASGGHVFDLVTEA-----------------YARGFY 693
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 65 GALVNRMGVDP-----------WHNWDAHYEVLP--------GKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLRE 125
Cdd:COG1110 694 GVLVENGRFIPvydtikrcldcGEQFTDEVEVCPrcgspnivDSLEIVEALRELATEVDEVLIGTDPDTEGEKIGWDVYN 773
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 126 VIGGDDARYSRVVFNEITKNAIRQAFEQPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARG-LSAGRVQSVAVRLV 204
Cdd:COG1110 774 LLRPYAKNIKRIEFHEVTRKAILEALKNPREIDENLVEAQIVRRIEDRWIGFTLSQKLWKVFGNRnLSAGRVQTPVLGWI 853
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 205 VEREREikaFVPEEFWEIDAntTTPSGEalpLQVTHQNDKPFRPVNREQTLAavsllEKARYSVLEREDKPTSSKPgaPF 284
Cdd:COG1110 854 IERYEE---SRKSKKYLIIL--TLENGR---LELSIEDLKEAEEVRKALEKE-----VKVKVKKVEEEEEELNPLP--PY 918
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 285 ITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLpdnpnqYASKENSQEA 364
Cdd:COG1110 919 TTDTLLRDASRRLGLSAEETMRLAQDLFESGLITYHRTDSTRVSDAGIAVAKEYISERFGEEYF------KPRRWGEGGA 992
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 365 HEAIRPSDvAVMAESLKDM------------EADAQKLYQLIWRQFVACQMTPA--QYDSTTLTVGAGEFRLKARG--RI 428
Cdd:COG1110 993 HEAIRPTR-PLDAEDLRRLieegvielpiplTRRHLRLYDLIFRRFMASQMRPAkvEKVKLRVSLELPGGEIEEERivEI 1071
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 429 LRfDGWTKVMPALRKGDEdrtlpaVNKGDaltlLELTPAQHFTKPPAR-FSEASLVKELEKRGIGRPSTYASIISTIQDR 507
Cdd:COG1110 1072 IE-DGFLLIYPPIKVEPE------LKEGE----YKVTEVKIRKVPKVPlYTQGDLVREMKERGIGRPSTYAKIVETLLRR 1140
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 16420244 508 GYVRVENRR--FYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKAVLDNFF 568
Cdd:COG1110 1141 GYVVESKKGkkLVPTKLGIEVYNYLSENFPDLVSEERTRELEEKMDEIEEGEADYQDVLEELY 1203
|
|
| rgy |
TIGR01054 |
reverse gyrase; This model describes reverse gyrase, found in both archaeal and bacterial ... |
4-568 |
1.20e-84 |
|
reverse gyrase; This model describes reverse gyrase, found in both archaeal and bacterial thermophiles. This enzyme, a fusion of a type I topoisomerase domain and a helicase domain, introduces positive supercoiling to increase the melting temperature of DNA double strands. Generally, these gyrases are encoded as a single polypeptide. An exception was found in Methanopyrus kandleri, where enzyme is split within the topoisomerase domain, yielding a heterodimer of gene products designated RgyB and RgyA. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273418 [Multi-domain] Cd Length: 1171 Bit Score: 294.05 E-value: 1.20e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 4 ALVIVESPAKAKTINKYLG-----------------NDYV--VKSSVGHIRDLPTSG----------------SAAKKSA 48
Cdd:TIGR01054 603 ALLVVESPNKARTIARFFGkpsvrkiggsvvyevpvGDLIlmITASGGHVFDLVTDKgfhgvlvengryvpvyTSIKRCR 682
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 49 DSTSTKTAKKPKKDERGAlvnrmgvdpwhnwdahyEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIG 128
Cdd:TIGR01054 683 DCGYQFTEDRESCPKCGS-----------------ENIEDSKSIIEILRELAHEVDEVFIGTDPDTEGEKIGWDLALLLS 745
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 129 GDDARYSRVVFNEITKNAIRQAFEQPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIA-RGLSAGRVQSVAVRLVVER 207
Cdd:TIGR01054 746 PYNPNVKRAEFHEVTRRAILEALESPRSVDENLVKAQVVRRIEDRWIGFTLSQKLWEAFNkRWLSAGRVQTPVLGWIIDR 825
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 208 EREIKAFVPEEFWEIDANtttpsgeALPLQVTHQNDKPFRPVNREQTLAAVSLLEkarysvlEREDKPTsskPGAPFITS 287
Cdd:TIGR01054 826 YRESREKRGYLLIFALES-------DFRLGLEHDNRLEAKEFEKDLTWLDVEDIA-------EREEERN---PLPPYTTD 888
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 288 TLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYlpdnpnQYASKENSQEAHEA 367
Cdd:TIGR01054 889 TMLEDANRKLGLSVKETMQIAQELFENGLITYHRTDSTRVSDVGMRVAKEYLASRLGGEY------FYPREWGEGGAHEC 962
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 368 IRPS------DVAVMAES----LKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRILR-FDGWTK 436
Cdd:TIGR01054 963 IRPTrpldvdDLQRLILEgvieLEGLTREHLRLYDLIFRRFMASQMRPAKVDTKEITLKADGKEAEEEGIVEIvERGFEL 1042
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 437 VMPALRKgdedrtlPAVNKGDALTLLELTPAQHFTKPParFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRR 516
Cdd:TIGR01054 1043 VYPLWRK-------NELEKGSTFIVKDKELRSVPKVYP--YTQGEIVQEMKERGIGRPSTYATIVEKLLRRGYVVESKGF 1113
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|..
gi 16420244 517 FYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKAVLDNFF 568
Cdd:TIGR01054 1114 LIPTKLGIEVYNYLTNRYPKLVSEDRTRELEEAMDKIERGELDYLEVLESVY 1165
|
|
| PRK07726 |
PRK07726 |
DNA topoisomerase 3; |
83-635 |
2.25e-80 |
|
DNA topoisomerase 3;
Pssm-ID: 236078 [Multi-domain] Cd Length: 658 Bit Score: 272.81 E-value: 2.25e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 83 YEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAwhlREVIggDDARY----SRVVFNEITKNAIRQAFEQ--PGE 156
Cdd:PRK07726 73 LVVKKKTAKQFNVVKKLLKQATEIVIATDADREGELIA---REIL--DYCGVrkpiKRLWISSLTDKAIKRAFANlkPGK 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 157 LNINRVNAQQARRFMDRVVGYMVSPLLWKKIARG-----LSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTpsG 231
Cdd:PRK07726 148 ETIPLYYSALARSRADWLVGINMTRAYTLLGRKAgyngvLSVGRVQTPTLALVVRRDEEIENFVPKPYWEVEAHLTP--G 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 232 EALPLQVTHQN---DKPFRPVNREQTLAAVSLLEKARYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMA 308
Cdd:PRK07726 226 ERFTAKWQPSEpyqDEEGRLLDRPLAEQVVARIQGQPAKVTEVETKRKKEYAPLLYDLSELQIDANKRFGLSAKETLDIA 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 309 QRLYE-AGYITYMRTDSTNLSQDAVNMVRGYIGD-NFGKKYLPDNPNQYASKENSQ-------EAHEAIRPSDVAVMAES 379
Cdd:PRK07726 306 QSLYEtHKLITYPRTDSRYLPEDMVATLPEVLNAiSKVDPYLLLAPPVLDPSIRSRawndkkvTAHHAIIPTEQPPNLSK 385
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 380 LKDMEadaQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKGDE-DRTLPAVNKGDA 458
Cdd:PRK07726 386 LSEDE---RKVYDLIARRYLAQFLPPAEYDKTTIELEIAGGTFIAKGKQVVEAGWKALLGKKEEDEEkEQPLPVLAKGDE 462
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 459 LTLLELTPAQHFTKPPARFSEASLV------------KELEKR-----GIGRPSTYASIISTIQDRGYVRVENRRFYAEK 521
Cdd:PRK07726 463 LKVEKGEVKEGQTQPPKRFTEGTLLsameniarfvqdKELKKTlketdGLGTEATRAGIIEKLFKRGYLEKKGKYIHATD 542
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 522 MGEIVTDRLEEnfrELMNYDFTAQMEDSLDQVANHQAEwkavLDNFFSDFTQQLDKAekdPEEGGMRPNQMVLTSID--- 598
Cdd:PRK07726 543 KGKQLIDALPE---ELTSPDMTAKWEQALDQISEGQLS----YQDFMQPLKQWLKQL---VEQAKQSSEKYKFDNLTgpk 612
|
570 580 590
....*....|....*....|....*....|....*..
gi 16420244 599 CPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTIN 635
Cdd:PRK07726 613 CPDCGKPMLKVKGKNGKMLVCQDRECGKRKNVSKKTN 649
|
|
| PRK07220 |
PRK07220 |
DNA topoisomerase I; Validated |
73-666 |
8.62e-75 |
|
DNA topoisomerase I; Validated
Pssm-ID: 180892 [Multi-domain] Cd Length: 740 Bit Score: 259.30 E-value: 8.62e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 73 VDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGG--DDARYSRVVFNEITKNAIRQA 150
Cdd:PRK07220 68 VDARDLIDAEIITTPTQKKIVTALKKLGKEADRVTIATDYDREGELIGVEALNIIKKvnPDIKFDRVRYSAITKKEIERA 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 151 FEQPGELNINRVNAQQARRFMDRVVGYMVSPllWKKIARG------LSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDA 224
Cdd:PRK07220 148 FSNPVEVDFNLADAGHSRQVIDLVWGAALTR--YISLAAGrlgkmfLSVGRVQSPTLALIVDREKEREAFVPTPYWEIYA 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 225 nTTTPSGEalPLQVTHQNDkpfRPVNREQTLAAVSLL-EKARYSVLEREDKptSSKPGAPFITSTLQQAASTrLGFGVKK 303
Cdd:PRK07220 226 -TLENNGE--TFVAQHSTR---RFWEKEEADRVFEKLgKTAEVTEVEKGTK--TDKPPTPFNTTEFISAANS-IGFSAAN 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 304 TMMMAQRLYEAGYITYMRTDST------NLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKENSQEaHEAIRPSDVAVMA 377
Cdd:PRK07220 297 AMRIAESLYTNGYISYPRTDNTvypeslDLREQIEIFAEGPFGEYAQKLLEKGELVPTRGKKETTD-HPPIYPASLAKKS 375
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 378 EslkdMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKgdEDRTLPAVNKGD 457
Cdd:PRK07220 376 E----LKEDEWKVYELVVRRFFATFAGPAEWETMKLRFDIGGEEFRANGSRLTEPGWRWYYPYNAP--EDRLLPELSEGE 449
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 458 ALTLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVR----VENRRFYAekmgeiVTDRLEEN 533
Cdd:PRK07220 450 ELKVKKKEMLDKETQPPGRYGQGRLIKLMEDLGLGTKATRHEIISKLYSRAYIHgnpiQPTNTAFA------VVDALEKY 523
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 534 FRELMNYDFTAQMEDSLDQVANHQAEWKAVLD---NFFSDFTQQLDKAEKDPEE---GGMRPNQMVLTsidCPTCGRKMG 607
Cdd:PRK07220 524 APTITKPDMTSRLEEDMDKIAEGKIKEDAVLEesrEMLEQVFDELDKNREKIREslrEGLREDKIIGK---CPLCGSDLM 600
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 608 IRTASTGV-FLGCSGYAlspkeRCKTTINLVPENEVLnVLEgddaetnalrakRRCQKCG 666
Cdd:PRK07220 601 VRRSKRGSrFIGCEGYP-----ECTFSLPLPKSGQII-VTD------------KVCEAHG 642
|
|
| topA_arch |
TIGR01057 |
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These ... |
79-622 |
1.32e-74 |
|
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These enzymes are involved in the control of DNA topology. DNA topoisomerase I belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273420 [Multi-domain] Cd Length: 618 Bit Score: 255.91 E-value: 1.32e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 79 WDAHYEVLPGKE---KVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDaRYSRVVFNEITKNAIRQAFEQPG 155
Cdd:TIGR01057 67 WVPIFEFDKGKGyvsKYIKALSKLAKGADEYINACDYDIEGEVIGFKALKYFCGVE-RAKRMKFSTLTKQDIRRAYANPE 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 156 ELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARG------LSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTP 229
Cdd:TIGR01057 146 EIDYGMVDAGMARHILDWYWGINLSRALMEAIRAAagrwviLSAGRVQGPTLAFLVEREREINLFVPKPYWVIKATLEKG 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 230 SGEalpLQVTHQNDKPFrpvNREQtlaAVSLLEKARYS----VLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTM 305
Cdd:TIGR01057 226 GGV---FDARPEKWKIW---SEEE---AKSIKEELKKSpwaaVEEVRSERSILKPPPPFDLGTLQREAYRIFGFSPKKTQ 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 306 MMAQRLYEAGYITYMRTDSTNLSQDA------VNMVRGYIGDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVAVMAES 379
Cdd:TIGR01057 297 SIAQELYEEALISYPRTSSQKLPPSInyrailDNLAKGPLYREAAERLLETGVLKPVEGKKEDPAHPAIHPTGEIPSQEL 376
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 380 LKDMEadaqKLYQLIWRQFVACQMTPA--QYDSTTLTVGAGEFRLkARGRILRfDGWTKVMPALRKGDEdrTLPAVNKGD 457
Cdd:TIGR01057 377 SKDEK----KVYDLIVRRFLAAFSEEAirEKSKVLLRIGQEKFRL-SGLRVVK-LGWLEYYHYSKFEEK--ELPPLDRGD 448
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 458 ALTLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVrVENRRFYAEKMGEIVTDRLEENFREL 537
Cdd:TIGR01057 449 KIKVVRVDVRVKETQPPARYDKASLIREMESRGLGTKATRARIIETLYKRGYI-EGKKSIKVTPLGEAVIETLQRYCPEI 527
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 538 MNYDFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEKDPEEGGM---RPNQMVLTSIDCPTCGRKMGIRTASTG 614
Cdd:TIGR01057 528 ISEELTRRFESKLEDIMSGRITKDEVIDEAKKRLRKILEEFKKRLDDIGIelgKSLGSVEVVGKCPKCGGKLVSKYAKKG 607
|
....*...
gi 16420244 615 VFLGCSGY 622
Cdd:TIGR01057 608 RFVGCSNY 615
|
|
| topB |
TIGR01056 |
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase ... |
3-622 |
5.07e-67 |
|
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase III from bacteria and its equivalents encoded on plasmids. The gene is designated topB if found in the bacterial chromosome, traE on conjugative plasmid RP4, etc. These enzymes are involved in the control of DNA topology. DNA topoisomerase III belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273419 [Multi-domain] Cd Length: 660 Bit Score: 235.89 E-value: 5.07e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 3 KALVIVESPAKAKTINKYL------------GNDYVVKSSVGHIRDLPTSGSAAKKSAdstSTKTAKKPKKDERGALVnr 70
Cdd:TIGR01056 1 MTLVLCEKPSQARDLATVLakkkkgngyleiGVGGFVTWAVGHLVELAEPEEYDEKYK---NWRTYDLPLEPEDWQLV-- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 71 mgvdpwhnwdahyeVLPGKEKVVSELKQL--AEKADHIYLATDLDREGEAIA-WHLREVIGGDDARYSRVVFNEITKNAI 147
Cdd:TIGR01056 76 --------------VSDKTKKQFNVIKRIlkENKVDEVVIATDPDREGELIArEILDYLKVTDKVTIKRLWISSLVDSSI 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 148 RQAFEQ--PGELNINRVNAQQARRFMDRVVGYMVSPLLWKK-----IARGLSAGRVQSVAVRLVVEREREIKAFVPEEFW 220
Cdd:TIGR01056 142 RKAFKNlrPKSETEGLYKSGVARARADWLVGINLTRAFTKLgreagNDGVLSVGRVQTPTLAMVVKRENEIKNFVGKPFY 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 221 EIDANTTTPsGEALPLQVTHQNDKPFRPVNREQTLAAVSLLEKARYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFG 300
Cdd:TIGR01056 222 EVSATINKD-EQEFTTEWQPYKDEEERELHEFLAENVVTDLTQKPALVTDIEKERKKTSAPLFYDLSALQEDANKRFGIS 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 301 VKKTMMMAQRLYEAG-YITYMRTDSTNLSQDAVNMVRGYIgdNFGKKYLPDNPNQYASKENSQ---------EAHEAIRP 370
Cdd:TIGR01056 301 AKRTLDIAQKLYETHkLITYPRTDSRYLPEDEKEMLLEVL--DALKVITPALLPIKKRDELTNnrlwndkkiEDHHAIIP 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 371 SDVAVMAESLKDMEAdaqKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKGDED--R 448
Cdd:TIGR01056 379 TGNDFNLSDLSEEER---NVYKLIAQNYLMQFMPKEEYETTTIEIAIGKLMFEAKGKILQDNGWKALLGKQEEDEETedT 455
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 449 TLPAVNKGDALTLLELTPAQHFTKPPARFSEASLVKEL-----------------EKRGIGRPSTYASIISTIQDRGYVR 511
Cdd:TIGR01056 456 TLPAFQKGDELDVETLELLEKQTKPPARYTEGTLLSAMtnpaafvqdkglkktlkETKGLGTEATRADIIENLFKRGFIQ 535
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 512 VENRRFYAEKMGEIVTDRLEEnfrELMNYDFTAQMEDSLDQVANHQAEwkavLDNFFSDFTQ---QLDKAEKDPEEGGMR 588
Cdd:TIGR01056 536 KKKNKIYITKNGKLLCLLLPE---LLTKPDLTAQWEQYLNGISAGEKD----DDDFINTINEmikQTINEEKKNPETIQK 608
|
650 660 670
....*....|....*....|....*....|....
gi 16420244 589 PNqmvltSIDCPTCGRKMgIRTASTGVFLGCSGY 622
Cdd:TIGR01056 609 VA-----KEPVSCGGIAK-CPAKDNGRLIDCKKF 636
|
|
| COG1754 |
COG1754 |
Uncharacterized C-terminal domain of topoisomerase IA [Function unknown]; |
1-639 |
3.58e-66 |
|
Uncharacterized C-terminal domain of topoisomerase IA [Function unknown];
Pssm-ID: 441360 [Multi-domain] Cd Length: 892 Bit Score: 238.18 E-value: 3.58e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 1 MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDErgalvnrmgvdpwhnwD 80
Cdd:COG1754 3 AAVLVVVVVVVVKVPAAKKVLPKYAKKKKGVKAVLKKADVAKADDKVVDDDDKKDDVDDDKKK----------------K 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 81 AHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEQPGELNIN 160
Cdd:COG1754 67 KKLLKAAAKKKKALALALAADDEDEELLAADDELEEEKVIKLLLLELAVERVARAAAVRAAAAEAARLAALLRRRLVLRR 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 161 RVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDAnTTTPSGEALPLQVTH 240
Cdd:COG1754 147 LVRRLLVRLLLLRLVLLLLRLLVARRAARRRRRRRRRRARRRELERRRERARAAEAEEAAAAAA-AAADAGRAAAARDGK 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 241 QNDKPFRPVNREQTLAAVSLLEKARYSVLEREDKPTSSKPgAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEA------ 314
Cdd:COG1754 226 GGGKLAAGGAAAAAAAAAAAAAAAAALAEAAAAAAVREPP-TPTTTTTAQAATTTTTRAAAARTTRSAQQAARRtrlgge 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 315 --GYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVAVMAESLKDMEA--DAQKL 390
Cdd:COG1754 305 gtYTTTTTTTTTTSAAAAAAAAAAAALAAAAAAAYAPPPPYYYKKKAAAAAAAAAAAAAAAARRPPAARAALLsdDRLLL 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 391 YQLIWRQFVACQM----TPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRK---GDEDRTLPAVNKGDALTLLE 463
Cdd:COG1754 385 ELLLLRRTAAAAAaaaaATATTTAAAAAAGAGAVGTAAAGAVFFFGGFLLFAEEEDDdeeDDDDDDLPALEEGLPLLKEG 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 464 LTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFT 543
Cdd:COG1754 465 VLADQHFTQPPPRYTEAPLVKRMEELGIGRPSTYASILSTLADRIYVRLDKRRLIPEDKGRLVTAFLFSFFRRYVEYDFT 544
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 544 AQMEDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEKDPEEGGMRPNQMvLTSID------CPTCGRKMGIRTASTGVFL 617
Cdd:COG1754 545 ADLEEFLDDVSDGELDWKAVLRRFWRDFSAAYDETGDLRISEVLDALED-LGEIDpreinsCPLGTGGLSLRVGRYGPFI 623
|
650 660
....*....|....*....|....*.
gi 16420244 618 GCSGY----ALSPKerCKTTINLVPE 639
Cdd:COG1754 624 ECSNYeprrASIPE--CLAPDELTPE 647
|
|
| PRK05776 |
PRK05776 |
DNA topoisomerase I; Provisional |
2-605 |
1.43e-64 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 235602 [Multi-domain] Cd Length: 670 Bit Score: 229.49 E-value: 1.43e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 2 GKALVIVESPAKAKTIN--------------------KYLGNDYVVKSSVGHIRDLPTsgsaakksadststktakkpkk 61
Cdd:PRK05776 1 GYILVIAEKPKAARKIAealsekpircriygvpywivKRDGKKIVVAPAAGHLFGLHT---------------------- 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 62 DERGALVNRMgvdpwhNWDAHYEVLPGK---EKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGgDDARYSRVV 138
Cdd:PRK05776 59 KSKGFPVFDY------EWKPLYEIDKGSkytKKYYELLSSLSKYADEFINACDYDIEGSVIGYLIIKYLG-DPKKAKRMK 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 139 FNEITKNAIRQAFEQPGELNINRVNAQQARRFMDRVVGYMVSPLLWK--KIARG----LSAGRVQSVAVRLVVEREREIK 212
Cdd:PRK05776 132 FSALTKSDIRRAFRNLETLDYEMINAGIARHELDWLWGINVSRALMSsvRDASGkrviLSAGRVQSPTLKYVVEREIERN 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 213 AFVPEEFWEIDAnTTTPSGEALPLQVThqnDKPFRPVNREQTLAAvSLLEKARYSVLEREDKPTSSKPGAPFITSTLQQA 292
Cdd:PRK05776 212 LFVPLPYFSVSI-IIEKNGYEFTLKYE---NKKFETKEEAKEILE-EIKKTGYLKVTKVEVKIEILEPPPPFNLGDLQVE 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 293 ASTRLGFGVKKTMMMAQRLYEAGYITYMRTDS-------------TNLSQdaVNMVRGYIGD--NFGKKYLpdNPNQyAS 357
Cdd:PRK05776 287 AARIYGFSPYKTQSIAEDLYLDGLISYPRTNSqklpptlnirnilKGLSR--SPQYRPLVNLllKETKGVL--KPVQ-GP 361
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 358 KENSqeAHEAIRPSdvavmAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDST--TLTVGAGEFRLKARGRILRFDGWT 435
Cdd:PRK05776 362 KDDP--AHPAIYPT-----GEPPKNLSKDEFKLYDLIVRRFLASFAAPAVLSNTivTLRVPGFPLVFSASGQRIEERGWL 434
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 436 KVMPaLRKGDEDrTLPAVNKGDALTLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENR 515
Cdd:PRK05776 435 KYYP-FHKFDEE-ELPLLKKGERVKIVDVKVRKSYTKPPSRYSKASLLKWMESVGIGTEATRARIIETLFKRGYLTSNGK 512
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 516 RFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKAVLD---NFFSDFTQQLDKAEKD-PEEGGMRPNQ 591
Cdd:PRK05776 513 YIEVTPLGFGVAEVLEKYFPDIVSVELTRDFEEKLEMIRTGKATREEVIEeakETLNKLLEEFKKNKDEiGEELAKALGL 592
|
650
....*....|....
gi 16420244 592 MVLTSiDCPTCGRK 605
Cdd:PRK05776 593 IKPVG-KCKICGRE 605
|
|
| PRK14973 |
PRK14973 |
DNA topoisomerase I; Provisional |
87-634 |
3.38e-64 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 184936 [Multi-domain] Cd Length: 936 Bit Score: 232.82 E-value: 3.38e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 87 PGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGG--DDARYSRVVFNEITKNAIRQAFEQPGELNINRVNA 164
Cdd:PRK14973 81 PTEKKIVGLIQKLAKKADRVTIATDFDTEGELIGKEAYELVRAvnPKVPIDRARFSAITKEEIVTAFAEPTDLDFALAAA 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 165 QQARRFMDRVVGYMVSPLLWKKIARG----LSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDAnTTTPSGEALPLQVTH 240
Cdd:PRK14973 161 GEARQIIDLIWGASLTRFISLAAHRGgdniLSVGRVQSPTLAMIVDREKEIEAFVPEKYWMLSL-ATEKDGEGIEARHTH 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 241 Q--NDKPFRPVNREQTLAAVSLLEKARYSVLERedKPTsskpgaPFITSTLQQAAStRLGFGVKKTMMMAQRLYEAGYIT 318
Cdd:PRK14973 240 GrfTDSAAAEAAYDATKEPLVVTEVKEGHKVDR--APT------PFDTTTFIVAAS-RLGFSAANAMRIAEDLYMNGYIS 310
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 319 YMRTDSTNL--SQDAVNMVRGYIGDNFGKK--YLPDN--PNQYASKENSQEaHEAIRPSDVAVMAEsLKDmeaDAQKLYQ 392
Cdd:PRK14973 311 YPRTDNTIYpkSLDLNGVLATLAKGAFSKDvaWVKDNrrPVPTRGKKSSTD-HPPIHPTGVATREE-LGD---DRWKLYE 385
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 393 LIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKgdEDRTLPAVNKGDALTLLELTPAQHFTK 472
Cdd:PRK14973 386 LVVRRFLATLSPDAEWATMKVNFDAGGEPYTATGGRLLEAGWRTVYPYSEA--KENILPAFALGEKLPILAVNLEEKETQ 463
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 473 PPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYvrVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQ 552
Cdd:PRK14973 464 PPARYSQSRLIQRMEELGLGTKSTRHEVIGKLVSRKY--IEGNPLRPTLVGRAVTESLEEHAGTITEPDMTQTLEEHMQQ 541
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 553 VANHQAEWKAVLDNFFSDFTQQLDKAEKDPEEGG---MRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYalsPKER 629
Cdd:PRK14973 542 IKERKRTRDDVVTESRKMLHRAFDELEANEAVIGrdiMERTAEELTIGPCPVCGKDLRIKHIGSSQFIGCSGY---PDCT 618
|
....*
gi 16420244 630 CKTTI 634
Cdd:PRK14973 619 FNIGL 623
|
|
| TOPRIM_TopoIA_TopoI |
cd03363 |
TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TOPRIM) domain found in members of the type IA ... |
3-154 |
3.32e-59 |
|
TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TOPRIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173783 [Multi-domain] Cd Length: 123 Bit Score: 197.40 E-value: 3.32e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 3 KALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGsaakksadststktakkpkkdergalvnrMGVDPWHN-WDA 81
Cdd:cd03363 1 KKLVIVESPAKAKTIKKYLGKEYEVLASVGHIRDLPKKG-----------------------------LGVDGEDDgFEP 51
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 16420244 82 HYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIgGDDARYSRVVFNEITKNAIRQAFEQP 154
Cdd:cd03363 52 KYVVIPGKKKVVKELKKLAKKADEIYLATDPDREGEAIAWHLAEVL-KLKKNVKRVVFNEITKEAIKEALKNP 123
|
|
| YrdD |
COG0551 |
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination ... |
43-738 |
3.42e-53 |
|
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination and repair];
Pssm-ID: 440317 [Multi-domain] Cd Length: 695 Bit Score: 197.39 E-value: 3.42e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 43 AAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122
Cdd:COG0551 22 KKKKKKEGKKKGLAGALGLKKKLVDLLLKEKLKKLVENEKLIAELDIKDLKKLKKDKKKKAKALAAALAAADDDAIEAAA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 123 LREVIGGDDARYSRVVFNEITKNAIRQAFEQPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVR 202
Cdd:COG0551 102 AADEEEALKAAEALEAIRKAVVEEVKSRARKRAARAPADVAAAAAAAALARLLLLAAASRALRLLLLLAAGRLRLLSAVA 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 203 LVVEREREIKAFVPEEFWEIDANTTTPSGEALPL---QVTHQNDKPFRPVNREQTLAAVSLLEKARYSVLEREDKPTSSK 279
Cdd:COG0551 182 AGLLELEELLKEFEEEEEEEAAEEEEEEEEAKKKkeeDKKKKKKKKKKDKEEETKAIKKKKKAAEAVLAAKKAAKEAKAK 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 280 PGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYI-----------TYMRTDSTNLSQDAVNMVRGYIGDNFGKKYL 348
Cdd:COG0551 262 KELPTTTTDALPEALATTSLTAAAAASALAAALLEEEGellytggyiryTRTPKSSEADALAALEALKKIAEEPPDERAK 341
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 349 PDNPNQYASKENSQEAHEAIRPSDVAVMAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRI 428
Cdd:COG0551 342 KKKKKAKKKKASEAKETTDHPPIPPTTAAALLELLEDRKLLLELLVRRRFAAAADLAKVEELTKVEEADEEELVEAEGGL 421
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 429 LRFDGWTKVMPAlrKGDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRG 508
Cdd:COG0551 422 LEVLGEEEEDDE--DEEEELLLPPLEEGEPLLLEELLLEKQTTTPPPRYTTELLLKKLEEEGGGGRGTTATIIILILKRR 499
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 509 YVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEKDPEEGGmR 588
Cdd:COG0551 500 YVVLEEKKTTPTELLVEVVLLLLLPFPKLEDTTETAEEEEALLDKEEGKEDKVVEIREEEYPFFKKLLEIAEEEGEEE-L 578
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 589 PNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYalsPKerCKTTINLvPENEVLNVlegddaetnalrakrRCQKCGTA 668
Cdd:COG0551 579 SEEDEVLGEKCPKCGKPLVIKKGRYGKFLGCSNY---PE--CKYTKPL-PKPEVTGV---------------KCPKCGKK 637
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 16420244 669 MDsyLIDPK--RKLHVCGNNPTCDgyeieegeFRIKgyDGPI-VECEKCGSEMHLKMGRFGkymaCTNDECKN 738
Cdd:COG0551 638 LV--LRKSKkgKVFYGCSNYPKCK--------FTEW--DKPVkEPCPKCGSPLVEKKTKKG----CANKLCGY 694
|
|
| PTZ00407 |
PTZ00407 |
DNA topoisomerase IA; Provisional |
5-580 |
1.50e-49 |
|
DNA topoisomerase IA; Provisional
Pssm-ID: 173597 [Multi-domain] Cd Length: 805 Bit Score: 188.23 E-value: 1.50e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 5 LVIVESPAKAKTINKYLGNDYVVKS---SVGHIRDLPTSGSAAKKSADS------------------TSTKTAKKPKKDE 63
Cdd:PTZ00407 12 LVIVESPNKVIKVEGLLSDPKVIPDwsfKQSHLRRIGTGAEKAVAMATTghfmalkeitwspqasspASVVGAGDEPFPS 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 64 RGALVNrmgvdpwhnWDAHYEVLPGK---EKVVSELKQLAEKADHIYLATDLDREGEAIAWH----LREVIGGDDARYSR 136
Cdd:PTZ00407 92 NGTLAE---------YTLEWELLPGRriqETLERYIEEKADNVTEIILATDPDREGELIAVHalqtIKRLYPKLKVPFSR 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 137 VVFNEITKNAIRQAFEQ--PGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAF 214
Cdd:PTZ00407 163 AYMHSITEDGIRKAMRErhVEACDYDLANAAETRHAMDRIFGFLGSSVVRAANSQMRSIGRVQTPALILINEREDKIKAF 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 215 VPEE--FWEIDA--NTTTPSGEALPLQVTHQNDKPFRPVNREQTLAAVSLLEKARYS-----VLEREDKPTSSK--PGAP 283
Cdd:PTZ00407 243 LESNksTFEVQAmcQFPSPHGTTFSQVVTITPDRKGGASHWATEAEARRCLEQWKLNnctgfSVPLEPKPQPSVvpPPQP 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 284 FITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKE---- 359
Cdd:PTZ00407 323 FTMATAIAKANRQLKYSSEMVSGCLQDLFQLGHITYPRTDSTRIDESALPDIYAAVKKEFGKEFLYRLEDRTVSAQegkg 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 360 ---------------------NSQEAHEAIRPSDVAVMAESLKdMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTV--- 415
Cdd:PTZ00407 403 skktgkkrstkqkkgadtpvgNVEDAHEAIRPTNIDTTGESLS-LSPPTRAVYDLVRRNTLAVFMIPMKTEKIVATVkft 481
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 416 -GAGE-FRLKARGRILRFDGWTKvmpALRKGDEDRTLPAV----------------------------------NKGDAL 459
Cdd:PTZ00407 482 sGSGEkLEFELQGKRVVEPGWTR---AFHKGDKGTTGPAEetdeditaveegapvvpslsqeefkaimnlrsqlGSGVQK 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 460 TLLELTPAQ---HFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENR-RFYAEKMGEIVTDRLEENFR 535
Cdd:PTZ00407 559 GFFELRSPQvreNRPVPPLPHSEGTLIEELKNNGVGRPSTYPMIVKTLLARGYIAVNPKgRCETTPVGRMLVETAKSTFP 638
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 536 ELMNYDFTAQMEDSLDQVAN---------------HQAEWkaVLDNFFSDFTQQLDKAEK 580
Cdd:PTZ00407 639 SIVDIGFTAAFEKKLDRIAKpgpakrpallrptnvSQADY--VLSMFLSTFLNYVTEATK 696
|
|
| PRK08173 |
PRK08173 |
DNA topoisomerase III; Validated |
1-515 |
1.60e-47 |
|
DNA topoisomerase III; Validated
Pssm-ID: 236172 [Multi-domain] Cd Length: 862 Bit Score: 182.56 E-value: 1.60e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 1 MGKALVIVESPAKAKTINKYLG-----------NDYVVKSSVGHIRDLptsgsAAKKSADststktakkPKkdeRGAlvn 69
Cdd:PRK08173 1 MSKALIIAEKPSVANDIARALGgftkhdeyfesDEYVLSSAVGHLLEI-----AAPEEYE---------VK---RGK--- 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 70 rmgvdpwhnWD-AHYEVLPGK------EKVVSELKQLAEKA-----DHIYLATDLDREGEAIAWHLREVIGGDDArYSRV 137
Cdd:PRK08173 61 ---------WSfAHLPVIPPHfdlnpiAKTESRLKVLTKLIkrkdvTRLINACDAGREGELIFRLIAQHAKAKKP-VKRL 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 138 VFNEITKNAIRQAFEQ--PGELNINRVNAQQARRFMDRVVGYMVSpllwkkiaRGLSA-------------GRVQSVAVR 202
Cdd:PRK08173 131 WLQSMTPQAIRDGFANlrSDEDMQPLADAARCRSEADWLVGINGT--------RAMTAfnskgggfflttvGRVQTPTLS 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 203 LVVEREREIKAFVPEEFWEIDANTTTPSG--EALPLQVTHQNDKpFRPVNREQTL----AAVSLLEKAR--YSVLEREDK 274
Cdd:PRK08173 203 IVVEREEKIRRFVPRDYWEVRAEFVAAAGfyEGRWFDPKFKKDE-FDPEKRASRLwseaAAEAIVAACRgkPGTVTEESK 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 275 PTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEA-GYITYMRTDSTNLSQDAVNMVRgyigDNFGKkyLPDNPN 353
Cdd:PRK08173 282 PSTQLSPLLFDLTSLQREANGRFGFSAKNTLGLAQALYEKhKVLTYPRTDSRALPEDYLGTVK----QTLEM--LKESNN 355
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 354 --QYASK--------------ENSQEA-HEAIRPSDVAvmAESLKDMEadaQKLYQLIWRQFVACQMTPAQYDSTT-LTV 415
Cdd:PRK08173 356 ylPHAKQildkgwvkpnkrifDNSKISdHFAIIPTLQA--PKSLSEPE---QKLYDLVVKRFLAVFFPAAEFLVTTrITE 430
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 416 GAGEfRLKARGRILRFDGWtKVMPALRKGDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEASLVKELE-------- 487
Cdd:PRK08173 431 VAGH-HFKTEGKVLVNPGW-LAVYGKEAQGADANLVPVQKGEKVKTDKIEAVALTTKPPARYNEATLLSAMEgagklved 508
|
570 580 590
....*....|....*....|....*....|....*.
gi 16420244 488 --------KRGIGRPSTYASIISTIQDRGYVRVENR 515
Cdd:PRK08173 509 delreamaEKGLGTPATRAAIIEGLLGEKYLVREGR 544
|
|
| TOP1Bc |
smart00436 |
Bacterial DNA topoisomeraes I ATP-binding domain; Extension of TOPRIM in Bacterial DNA ... |
134-221 |
3.02e-43 |
|
Bacterial DNA topoisomeraes I ATP-binding domain; Extension of TOPRIM in Bacterial DNA topoisomeraes I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase beta subunit
Pssm-ID: 214662 [Multi-domain] Cd Length: 89 Bit Score: 151.58 E-value: 3.02e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 134 YSRVVFNEITKNAIRQAFEQPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIAR-GLSAGRVQSVAVRLVVEREREIK 212
Cdd:smart00436 1 IKRIEFSEITKKAIREALKNPREIDENLVNAQLARRILDRLIGFNLSRLLTKKLRNgVLSAGRVQTPTLGLIVEREREIK 80
|
....*....
gi 16420244 213 AFVPEEFWE 221
Cdd:smart00436 81 NFVPKPYWE 89
|
|
| TOPRIM_TopoIA |
cd01028 |
TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the ... |
3-154 |
1.24e-42 |
|
TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IA family of DNA topoisomerases (TopoIA). This subgroup contains proteins similar to the Type I DNA topoisomerases: E. coli topisomerases I and III, eukaryotic topoisomerase III and, ATP-dependent reverse gyrase found in archaea and thermophilic bacteria. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA. These enzymes cleave one strand of the DNA duplex, covalently link to the 5' phosphoryl end of the DNA break and allow the other strand of the duplex to pass through the gap. Reverse gyrase is also able to insert positive supercoils in the presence of ATP and negative supercoils in the presence of AMPPNP. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173778 [Multi-domain] Cd Length: 142 Bit Score: 151.61 E-value: 1.24e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 3 KALVIVESPAKAKTINKYLG------------NDYVVKSSVGHIRDLPTsgsaakksadststktakkpkkDERGALVNR 70
Cdd:cd01028 1 KVLIIAEKPSKAKTIAKILGkgskkkgfygegGGYVVTASVGHLLELPF----------------------PEEYVDWDK 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 71 MGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQA 150
Cdd:cd01028 59 DWPLELFPFEPKYVVIPDKKKQLKALKKLAKKADEIVLATDPDREGELIAWEILEVLKCDNKPVKRAWFSEITPKAIREA 138
|
....
gi 16420244 151 FEQP 154
Cdd:cd01028 139 FKNL 142
|
|
| PRK14724 |
PRK14724 |
DNA topoisomerase III; Provisional |
3-629 |
3.18e-37 |
|
DNA topoisomerase III; Provisional
Pssm-ID: 237803 [Multi-domain] Cd Length: 987 Bit Score: 150.88 E-value: 3.18e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 3 KALVIVESPAKAKTI--------------NKYLGND-YVVKSSVGHIRDLptsgsaakKSADSTSTKTAKkpkkderGAL 67
Cdd:PRK14724 2 KTLVIAEKPSVAQDIvraltpvagkfekhDEHFESDsYVVTSAVGHLVEI--------QAPEEFDVKRGK-------WSF 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 68 VNRMGVDPwhnwdaHYEVLPgKEKVVSELK---QLAEKADHIYL--ATDLDREGEAIAWHLREVIGGDDARYSRVV---- 138
Cdd:PRK14724 67 ANLPVIPP------YFDLKP-VDKTKTRLNavvKLAKRKDVTELvnACDAGREGELIFRLIEQYAGGAKGGLGKPVkrlw 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 139 FNEITKNAIRQAFE--QPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARG-----LSAGRVQSVAVRLVVEREREI 211
Cdd:PRK14724 140 LQSMTPQAIRDGFDnlRSDAQMQGLASAARSRSEADWLVGINGTRAMTAFNSRDggfflTTVGRVQTPTLSLVVEREEKI 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 212 KAFVPEEFWEIDANTTTPSGEALPLQVTHQNDKPF--------RPVNREQTLAAVSLLEKARYSVLErEDKPTSSKPGAP 283
Cdd:PRK14724 220 RKFVSRDYWEIHAGFHAEAGEYLGKWFDPQWKKASddpearadRVWSEREARAIADAVRGKAATVTE-ESKPTTQASPLL 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 284 FITSTLQQAASTRLGFGVKKTMMMAQRLYEA-GYITYMRTDSTNLSQDAVNMVRGYIG----------DNFGKKYLPDN- 351
Cdd:PRK14724 299 FDLTSLQREANGKFGFSAKTTLALAQSLYERhKALTYPRTDSRALPEDYLPVAKQTFEmlatsgmrhlAPFAQQALDGNy 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 352 --PNQYASKENSQEAHEAIRPSDVAvmAESLKDMEadaQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRIL 429
Cdd:PRK14724 379 vrPSKRIFDNSKVSDHFAIIPTTQA--PSGLSEAE---QKLYDLVVRRFMAVFFPSAEYQVTTRISQVVGHSFKTEGKVL 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 430 RFDGWTKV--------MPALRKGDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEASLVKELE-------------- 487
Cdd:PRK14724 454 VKPGWLAIygkeaaneVEDAKDGDKGQPLVPVKPGEMVRTEFAEAKGLKTKPPARYSEATLLGAMEsagkqidddelrea 533
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 488 --KRGIGRPSTYASIISTIQDRGYVRVENRRFY-AEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKAVL 564
Cdd:PRK14724 534 mqEKGLGTPATRAAIIEGLLTEKYMLREGRELIpTAKAFQLMTLLRGLGVEELSRAELTGEWEYKLAQMEKGQLSREAFM 613
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 16420244 565 DNfFSDFTQQLDKAEKDPEEGGMrPNQMVLTSIDCPTCG-------RKMGIrTASTGVFLGCS-GYALSPKER 629
Cdd:PRK14724 614 QQ-IAAMTEKLVKKAKEYDRDTI-PGDYATLSTPCPNCGgvvkenyRRYAC-TGANGAGEGCGfSFTKSPAGR 683
|
|
| Topo_Zn_Ribbon |
pfam08272 |
Topoisomerase I zinc-ribbon-like; Some Proteobacteria topoisomerase I contain two ... |
824-862 |
3.63e-20 |
|
Topoisomerase I zinc-ribbon-like; Some Proteobacteria topoisomerase I contain two zinc-ribbon-like domains at the C-terminus that structurally homologous to pfam01396. However, this domain no longer bind zinc. Indeed, only one of the four cysteine residues remains.
Pssm-ID: 462415 [Multi-domain] Cd Length: 39 Bit Score: 84.25 E-value: 3.63e-20
10 20 30
....*....|....*....|....*....|....*....
gi 16420244 824 GNKTVVRFSRKTKQQYVAAEKDGKATGWSAFFVDGKWVE 862
Cdd:pfam08272 1 GNPALVRFSRKTKEQYVLSEVDGKATGWLAAYTDGKWRE 39
|
|
| TOPRIM_TopoIA_TopoIII |
cd03362 |
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type ... |
3-154 |
1.33e-19 |
|
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173782 [Multi-domain] Cd Length: 151 Bit Score: 86.13 E-value: 1.33e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 3 KALVIVESPAKAKTI------------------NKYLGNDYVVKSSVGHIRDLptsgsaakksadststktakkpkkDER 64
Cdd:cd03362 1 MVLIIAEKPSVAKAIakilgggskkkgkgryyeFYGEGGGYVVTWASGHLLEL------------------------DFP 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 65 GALVNRMGVDPWHN----WDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIG-GDDARYSRVVF 139
Cdd:cd03362 57 EEYDPWDKVWPLEDplfpAPFKLKVDKGKKKQFKVLKKLAKRADEIVIATDADREGELIGREILEYAKcVKRKPVKRAWF 136
|
170
....*....|....*
gi 16420244 140 NEITKNAIRQAFEQP 154
Cdd:cd03362 137 SSLTPKAIRRAFKNL 151
|
|
| Toprim |
pfam01751 |
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim ... |
4-142 |
1.59e-18 |
|
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely abolish DnaG type primase activity. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesizes the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases. Type II DNA topoisomerases catalyze the relaxation of DNA supercoiling by causing transient double strand breaks.
Pssm-ID: 396354 [Multi-domain] Cd Length: 93 Bit Score: 81.25 E-value: 1.59e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 4 ALVIVESPAKAKTINKYLG-NDYVVKSSVGHIRDLPTsgsaakksadststktakkpkkdergalvnrmgvdpwhnwdah 82
Cdd:pfam01751 1 ELIIVEGPSDAIALEKALGgGFQAVVAVLGHLLSLEK------------------------------------------- 37
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 83 yevlPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEI 142
Cdd:pfam01751 38 ----GPKKKALKALKELALKAKEVILATDPDREGEAIALKLLELKELLENAGGRVEFSEL 93
|
|
| TOPRIM_TopoIA_RevGyr |
cd03361 |
TopoIA_RevGyr : The topoisomerase-primase (TORPIM) domain found in members of the type IA ... |
4-154 |
7.67e-18 |
|
TopoIA_RevGyr : The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to the ATP-dependent reverse gyrase found in archaea and thermophilic bacteria. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. Reverse gyrase is also able to insert positive supercoils in the presence of ATP and negative supercoils in the presence of AMPPNP. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173781 [Multi-domain] Cd Length: 170 Bit Score: 81.98 E-value: 7.67e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 4 ALVIVESPAKAKTINKYLG-----------------NDYV--VKSSVGHIRDLPTSG----------------SAAKKSA 48
Cdd:cd03361 2 ALMIVESPNKARTIANFFGrpsvrrlgglvvyevstGDGVlmITASGGHVYDLVTKEgghgvveddgryvpvyDSIKRCR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 49 DSTSTKTAKKPKKDERGAlvnrmgvdpwhnwdahyEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIG 128
Cdd:cd03361 82 DCGYQFTEDSDKCPRCGS-----------------ENIDDKLETLEALRELALEVDEVLIATDPDTEGEKIAWDVYLALR 144
|
170 180
....*....|....*....|....*.
gi 16420244 129 GDDARYSRVVFNEITKNAIRQAFEQP 154
Cdd:cd03361 145 PYNKNIKRAEFHEVTRRAILEALRNP 170
|
|
| TOPRIM |
smart00493 |
topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins; |
3-131 |
4.33e-15 |
|
topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins;
Pssm-ID: 214695 [Multi-domain] Cd Length: 75 Bit Score: 70.75 E-value: 4.33e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 3 KALVIVESPAKAKTINKYLGNDYVVKSSVGHIRdlptsgsaakksadststktakkpkkdergalvnrmgvdpwhnwdah 82
Cdd:smart00493 1 KVLIIVEGPADAIALEKAGGKRGNVVALGGHLL----------------------------------------------- 33
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 16420244 83 yevlpgKEKVVSELKQLAEKAdHIYLATDLDREGEAIAWHLREVIGGDD 131
Cdd:smart00493 34 ------SKEQIKLLKKLAKKA-EVILATDPDREGEAIAWELAELLKPAG 75
|
|
| zf-C4_Topoisom |
pfam01396 |
Topoisomerase DNA binding C4 zinc finger; |
708-745 |
1.23e-12 |
|
Topoisomerase DNA binding C4 zinc finger;
Pssm-ID: 307520 [Multi-domain] Cd Length: 39 Bit Score: 62.66 E-value: 1.23e-12
10 20 30
....*....|....*....|....*....|....*....
gi 16420244 708 IVECEKCGSEMHLKMGRFGKYMACTN-DECKNTRKILRN 745
Cdd:pfam01396 1 GGKCPKCGGDLVLKRGRFGKFVGCSNyPECRFTRPLKKN 39
|
|
| TOPRIM |
cd00188 |
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type ... |
3-139 |
1.31e-10 |
|
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from bacterial and archaea, and bacterial DNA repair proteins of the RecR/M family. This domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in nucleotide polymerization by primases and in strand joining in topoisomerases and, as a general acid in strand cleavage by topisomerases and nucleases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173773 [Multi-domain] Cd Length: 83 Bit Score: 58.21 E-value: 1.31e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16420244 3 KALVIVESPAKAKTINKYLGNDYVVKSSVGHIRdlptsgsaakksadststktakkpkkdergalvnrmgvdpwhnwdah 82
Cdd:cd00188 1 KKLIIVEGPSDALALAQAGGYGGAVVALGGHAL----------------------------------------------- 33
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 16420244 83 yevlpgkEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVF 139
Cdd:cd00188 34 -------NKTRELLKRLLGEAKEVIIATDADREGEAIALRLLELLKSLGKKVRRLLL 83
|
|
| Topo_Zn_Ribbon |
pfam08272 |
Topoisomerase I zinc-ribbon-like; Some Proteobacteria topoisomerase I contain two ... |
757-791 |
9.21e-08 |
|
Topoisomerase I zinc-ribbon-like; Some Proteobacteria topoisomerase I contain two zinc-ribbon-like domains at the C-terminus that structurally homologous to pfam01396. However, this domain no longer bind zinc. Indeed, only one of the four cysteine residues remains.
Pssm-ID: 462415 [Multi-domain] Cd Length: 39 Bit Score: 48.82 E-value: 9.21e-08
10 20 30
....*....|....*....|....*....|....*....
gi 16420244 757 PLPELP--CEKSDAYFVLR--DGAAGIFLAANTFPKSRE 791
Cdd:pfam08272 1 GNPALVrfSRKTKEQYVLSevDGKATGWLAAYTDGKWRE 39
|
|
| zf-C4_Topoisom |
pfam01396 |
Topoisomerase DNA binding C4 zinc finger; |
597-638 |
7.09e-05 |
|
Topoisomerase DNA binding C4 zinc finger;
Pssm-ID: 307520 [Multi-domain] Cd Length: 39 Bit Score: 40.70 E-value: 7.09e-05
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 16420244 597 IDCPTCGRKMGIRTASTGVFLGCSGYalsPKerCKTTINLVP 638
Cdd:pfam01396 2 GKCPKCGGDLVLKRGRFGKFVGCSNY---PE--CRFTRPLKK 38
|
|
| |
