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Conserved domains on  [gi|15291989|gb|AAK93263|]
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LD34385p [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Foie-gras_1 super family cl20424
Foie gras liver health family 1; Mutating the gene foie gras in zebrafish has been shown to ...
 1-158 1.61e-56

Foie gras liver health family 1; Mutating the gene foie gras in zebrafish has been shown to affect development; the mutants develop large, lipid-filled hepatocytes in the liver, resembling those in individuals with fatty liver disease. Foie-gras protein is long and has several well-defined domains though none of them has a known function. We have annotated this one as the first. The C-terminus of this region contains TPR repeats.


The actual alignment was detected with superfamily member pfam11817:

Pssm-ID: 463359  Cd Length: 248  Bit Score: 195.30  E-value: 1.61e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15291989     1 MKRRdaameaYAAMQASSEATPTPIQNPLS-LYTEFFGIRavkTGDLVAEQQANMQLCDQERSYNHSAAIIALLSQAMAQ 79
Cdd:pfam11817  99 MARR------SLAEQIPEEDRVPPGQSPASsLASSFYVYD---TYLAPEPHEEYPLSGSEEKGVDHSTLIIALLSRALAE 169

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15291989    80 FKIYKCLRFRKKLAIDMAEEYLKSGDHAKALTLYSLMLPDYRQEKWTTIFTDVLLKTLRCALLSGSVADYIACSVEALS 158
Cdd:pfam11817 170 FSKRKQTRMAALLSLEMAEEYLRLGDWAKALELLRPLTLSYRQEGWWTLLEEVLWALRECALLVGDVKDVLAVDWELLS 248
Gryzun super family cl29758
Gryzun, putative trafficking through Golgi; The proteins featured in this family are all ...
 873-916 6.31e-07

Gryzun, putative trafficking through Golgi; The proteins featured in this family are all eukaryotic, and many of them are annotated as being Gryzun. Gryzun is distantly related to, but distinct from, the Trs130 subunit of the TRAPP complex but is absent from S. cerevisiae. RNAi of human Gryzun blocks Golgi exit. Thus the family is likely to be involved with trafficking of proteins through membranes, perhaps as part of the TRAPP complex.


The actual alignment was detected with superfamily member pfam12742:

Pssm-ID: 453052  Cd Length: 56  Bit Score: 46.99  E-value: 6.31e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 15291989   873 LSISKTDNFICSGHKQLDISIMAYEEKELVYNLYPLQVGWQELP 916
Cdd:pfam12742   9 IIVEESDNFFFSGPKKLNFHMWPGEEQEIPFNFYPLMAGLLYLP 52
 
Name Accession Description Interval E-value
Foie-gras_1 pfam11817
Foie gras liver health family 1; Mutating the gene foie gras in zebrafish has been shown to ...
 1-158 1.61e-56

Foie gras liver health family 1; Mutating the gene foie gras in zebrafish has been shown to affect development; the mutants develop large, lipid-filled hepatocytes in the liver, resembling those in individuals with fatty liver disease. Foie-gras protein is long and has several well-defined domains though none of them has a known function. We have annotated this one as the first. The C-terminus of this region contains TPR repeats.


Pssm-ID: 463359  Cd Length: 248  Bit Score: 195.30  E-value: 1.61e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15291989     1 MKRRdaameaYAAMQASSEATPTPIQNPLS-LYTEFFGIRavkTGDLVAEQQANMQLCDQERSYNHSAAIIALLSQAMAQ 79
Cdd:pfam11817  99 MARR------SLAEQIPEEDRVPPGQSPASsLASSFYVYD---TYLAPEPHEEYPLSGSEEKGVDHSTLIIALLSRALAE 169

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15291989    80 FKIYKCLRFRKKLAIDMAEEYLKSGDHAKALTLYSLMLPDYRQEKWTTIFTDVLLKTLRCALLSGSVADYIACSVEALS 158
Cdd:pfam11817 170 FSKRKQTRMAALLSLEMAEEYLRLGDWAKALELLRPLTLSYRQEGWWTLLEEVLWALRECALLVGDVKDVLAVDWELLS 248
Gryzun-like pfam12742
Gryzun, putative Golgi trafficking; Members of this family are involved in Golgi trafficking.
 873-916 6.31e-07

Gryzun, putative Golgi trafficking; Members of this family are involved in Golgi trafficking.


Pssm-ID: 403829  Cd Length: 56  Bit Score: 46.99  E-value: 6.31e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 15291989   873 LSISKTDNFICSGHKQLDISIMAYEEKELVYNLYPLQVGWQELP 916
Cdd:pfam12742   9 IIVEESDNFFFSGPKKLNFHMWPGEEQEIPFNFYPLMAGLLYLP 52
 
Name Accession Description Interval E-value
Foie-gras_1 pfam11817
Foie gras liver health family 1; Mutating the gene foie gras in zebrafish has been shown to ...
 1-158 1.61e-56

Foie gras liver health family 1; Mutating the gene foie gras in zebrafish has been shown to affect development; the mutants develop large, lipid-filled hepatocytes in the liver, resembling those in individuals with fatty liver disease. Foie-gras protein is long and has several well-defined domains though none of them has a known function. We have annotated this one as the first. The C-terminus of this region contains TPR repeats.


Pssm-ID: 463359  Cd Length: 248  Bit Score: 195.30  E-value: 1.61e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15291989     1 MKRRdaameaYAAMQASSEATPTPIQNPLS-LYTEFFGIRavkTGDLVAEQQANMQLCDQERSYNHSAAIIALLSQAMAQ 79
Cdd:pfam11817  99 MARR------SLAEQIPEEDRVPPGQSPASsLASSFYVYD---TYLAPEPHEEYPLSGSEEKGVDHSTLIIALLSRALAE 169

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15291989    80 FKIYKCLRFRKKLAIDMAEEYLKSGDHAKALTLYSLMLPDYRQEKWTTIFTDVLLKTLRCALLSGSVADYIACSVEALS 158
Cdd:pfam11817 170 FSKRKQTRMAALLSLEMAEEYLRLGDWAKALELLRPLTLSYRQEGWWTLLEEVLWALRECALLVGDVKDVLAVDWELLS 248
Gryzun-like pfam12742
Gryzun, putative Golgi trafficking; Members of this family are involved in Golgi trafficking.
 873-916 6.31e-07

Gryzun, putative Golgi trafficking; Members of this family are involved in Golgi trafficking.


Pssm-ID: 403829  Cd Length: 56  Bit Score: 46.99  E-value: 6.31e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 15291989   873 LSISKTDNFICSGHKQLDISIMAYEEKELVYNLYPLQVGWQELP 916
Cdd:pfam12742   9 IIVEESDNFFFSGPKKLNFHMWPGEEQEIPFNFYPLMAGLLYLP 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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