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Conserved domains on  [gi|13814411|gb|AAK41461|]
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Carbonic anhydrase [Saccharolobus solfataricus P2]

Protein Classification

beta-class carbonic anhydrase( domain architecture ID 10130171)

beta-class carbonic anhydrase similar to carbonic anhydrase (CA) that catalyzes the zinc-dependent reversible hydration of carbon dioxide into bicarbonate and a proton, and to carbon disulfide hydrolase that catalyzes the conversion of carbon disulfide into hydrogen sulfide and carbon dioxide, with carbonyl sulfide as an intermediate

Gene Ontology:  GO:0004089|GO:0008270

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
beta_CA_cladeD cd03379
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 27-185 2.48e-59

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


:

Pssm-ID: 239474  Cd Length: 142  Bit Score: 182.45  E-value: 2.48e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13814411  27 DRRLWILTCMDERVHVEEALGIRPEDAHIYRNAGGIVTDDAIRSASLTTNFFGTKEIIVITHTDCGMIRFTGDEVAKYFL 106
Cdd:cd03379   2 ARKLAIVTCMDARLDPEKALGLKLGDAKVIRNAGGRVTDDAIRSLVVSVYLLGTREIIVIHHTDCGMLTFTDEELKEKMK 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13814411 107 DKGVkvnelqidpllpslrlqsTEDFTKWFKFFRDLGANSPDDIALKNAEILKNHPLIPKNVTISAYVYEVETHKLRKP 185
Cdd:cd03379  82 ERGI------------------AEAYGGIDKEFWFLGFDDLEESVREDVERIRNHPLIPDDVPVHGYVYDVKTGKLTEV 142
 
Name Accession Description Interval E-value
beta_CA_cladeD cd03379
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 27-185 2.48e-59

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 239474  Cd Length: 142  Bit Score: 182.45  E-value: 2.48e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13814411  27 DRRLWILTCMDERVHVEEALGIRPEDAHIYRNAGGIVTDDAIRSASLTTNFFGTKEIIVITHTDCGMIRFTGDEVAKYFL 106
Cdd:cd03379   2 ARKLAIVTCMDARLDPEKALGLKLGDAKVIRNAGGRVTDDAIRSLVVSVYLLGTREIIVIHHTDCGMLTFTDEELKEKMK 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13814411 107 DKGVkvnelqidpllpslrlqsTEDFTKWFKFFRDLGANSPDDIALKNAEILKNHPLIPKNVTISAYVYEVETHKLRKP 185
Cdd:cd03379  82 ERGI------------------AEAYGGIDKEFWFLGFDDLEESVREDVERIRNHPLIPDDVPVHGYVYDVKTGKLTEV 142
Pro_CA smart00947
Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the ...
 32-183 2.76e-24

Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In Escherichia coli, CA (gene cynT) is involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (gene cynS). By this action, it prevents the depletion of cellular bicarbonate. In photosynthetic bacteria and plant chloroplast, CA is essential to inorganic carbon fixation. Prokaryotic and plant chloroplast CA are structurally and evolutionary related and form a family distinct from the one which groups the many different forms of eukaryotic CA's.


Pssm-ID: 214929 [Multi-domain]  Cd Length: 154  Bit Score: 93.34  E-value: 2.76e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13814411     32 ILTCMDERVHVEEALGIRPEDAHIYRNAGGIV---TDDAIRSASLTTNFFGTKEIIVITHTDCGMIRFTGDEVAKyFLDK 108
Cdd:smart00947  10 IIGCSDSRVPPELIFGLGPGDLFVIRNAGNIVppyDDGVLASLEYAVEVLGVKEIVVCGHTDCGAVKAALDDEPG-LIDN 88

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 13814411    109 GVKvnelQIDPLLPSLRLQSTEDFTKWFKFFRDLGANspddiaLKNAEILKNHPLIPKnVTISAYVYEVETHKLR 183
Cdd:smart00947  89 WLE----RIRPARERALEELGDVDALEELNVRDQVEN------LRTSPAIREAVAKGK-LKVHGWVYDIETGKLE 152
Pro_CA pfam00484
Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of ...
 30-95 2.92e-10

Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of non-functional homologs related to YbcF.


Pssm-ID: 459828  Cd Length: 156  Bit Score: 56.36  E-value: 2.92e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13814411    30 LWIlTCMDERVHVEEALGIRPEDAHIYRNAGGIV--TDDAIrSASL--TTNFFGTKEIIVITHTDCGMIR 95
Cdd:pfam00484   2 LII-GCSDSRVPPELIFDTGPGDLFVVRNAGNLVppYDLNV-LASIeyAVEVLKVKHIVVCGHSGCGAVK 69
CynT COG0288
Carbonic anhydrase [Inorganic ion transport and metabolism];
30-97 3.04e-08

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 440057  Cd Length: 204  Bit Score: 51.70  E-value: 3.04e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13814411  30 LWIlTCMDERVHVEEALGIRPEDAHIYRNAGGIV--TDDAIrSASLT--TNFFGTKEIIVITHTDCGMIRFT 97
Cdd:COG0288  38 LVI-GCSDSRVPPELIFDQGPGDLFVVRNAGNVVppYDPGV-LASIEyaVEVLGVKLIVVLGHSGCGAVKAA 107
PRK15219 PRK15219
carbonic anhydrase; Provisional
 32-101 4.17e-05

carbonic anhydrase; Provisional


Pssm-ID: 237927 [Multi-domain]  Cd Length: 245  Bit Score: 42.90  E-value: 4.17e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13814411   32 ILTCMDERVHVEEALGIRPEDAHIYRNAGGIVTDDAIRSASLTTNFFGTKEIIVITHTDCGMIRFTGDEV 101
Cdd:PRK15219  94 ILSCIDSRAPAEIILDTGIGETFNSRVAGNISNDDLLGSMEFACAVAGAKVVLVMGHTACGAVKGAIDNV 163
 
Name Accession Description Interval E-value
beta_CA_cladeD cd03379
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 27-185 2.48e-59

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 239474  Cd Length: 142  Bit Score: 182.45  E-value: 2.48e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13814411  27 DRRLWILTCMDERVHVEEALGIRPEDAHIYRNAGGIVTDDAIRSASLTTNFFGTKEIIVITHTDCGMIRFTGDEVAKYFL 106
Cdd:cd03379   2 ARKLAIVTCMDARLDPEKALGLKLGDAKVIRNAGGRVTDDAIRSLVVSVYLLGTREIIVIHHTDCGMLTFTDEELKEKMK 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13814411 107 DKGVkvnelqidpllpslrlqsTEDFTKWFKFFRDLGANSPDDIALKNAEILKNHPLIPKNVTISAYVYEVETHKLRKP 185
Cdd:cd03379  82 ERGI------------------AEAYGGIDKEFWFLGFDDLEESVREDVERIRNHPLIPDDVPVHGYVYDVKTGKLTEV 142
beta_CA cd00382
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 27-184 7.82e-27

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238224 [Multi-domain]  Cd Length: 119  Bit Score: 98.73  E-value: 7.82e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13814411  27 DRRLWILTCMDERVHVEEALGIRPEDAHIYRNAGGIVTD---DAIRSASLTTNFFGTKEIIVITHTDCGMIRFTgdevak 103
Cdd:cd00382   2 KPKALIIGCSDSRVPPELIFGLGPGDLFVVRNAGNLVPPydlDVLASLEYAVEVLGVKHIIVCGHTDCGAVKAL------ 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13814411 104 yfldkgVKVNELQidpllpslrlqstedftkwfkffrdlganspddialkNAEILKNHPLI-----PKNVTISAYVYEVE 178
Cdd:cd00382  76 ------VEENVRE-------------------------------------QVENLRSHPLIqeavaPGELKVHGWVYDIE 112


                ....*.
gi 13814411 179 THKLRK 184
Cdd:cd00382 113 TGKLEV 118
Pro_CA smart00947
Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the ...
 32-183 2.76e-24

Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In Escherichia coli, CA (gene cynT) is involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (gene cynS). By this action, it prevents the depletion of cellular bicarbonate. In photosynthetic bacteria and plant chloroplast, CA is essential to inorganic carbon fixation. Prokaryotic and plant chloroplast CA are structurally and evolutionary related and form a family distinct from the one which groups the many different forms of eukaryotic CA's.


Pssm-ID: 214929 [Multi-domain]  Cd Length: 154  Bit Score: 93.34  E-value: 2.76e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13814411     32 ILTCMDERVHVEEALGIRPEDAHIYRNAGGIV---TDDAIRSASLTTNFFGTKEIIVITHTDCGMIRFTGDEVAKyFLDK 108
Cdd:smart00947  10 IIGCSDSRVPPELIFGLGPGDLFVIRNAGNIVppyDDGVLASLEYAVEVLGVKEIVVCGHTDCGAVKAALDDEPG-LIDN 88

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 13814411    109 GVKvnelQIDPLLPSLRLQSTEDFTKWFKFFRDLGANspddiaLKNAEILKNHPLIPKnVTISAYVYEVETHKLR 183
Cdd:smart00947  89 WLE----RIRPARERALEELGDVDALEELNVRDQVEN------LRTSPAIREAVAKGK-LKVHGWVYDIETGKLE 152
Pro_CA pfam00484
Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of ...
 30-95 2.92e-10

Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of non-functional homologs related to YbcF.


Pssm-ID: 459828  Cd Length: 156  Bit Score: 56.36  E-value: 2.92e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13814411    30 LWIlTCMDERVHVEEALGIRPEDAHIYRNAGGIV--TDDAIrSASL--TTNFFGTKEIIVITHTDCGMIR 95
Cdd:pfam00484   2 LII-GCSDSRVPPELIFDTGPGDLFVVRNAGNLVppYDLNV-LASIeyAVEVLKVKHIVVCGHSGCGAVK 69
CynT COG0288
Carbonic anhydrase [Inorganic ion transport and metabolism];
30-97 3.04e-08

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 440057  Cd Length: 204  Bit Score: 51.70  E-value: 3.04e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13814411  30 LWIlTCMDERVHVEEALGIRPEDAHIYRNAGGIV--TDDAIrSASLT--TNFFGTKEIIVITHTDCGMIRFT 97
Cdd:COG0288  38 LVI-GCSDSRVPPELIFDQGPGDLFVVRNAGNVVppYDPGV-LASIEyaVEVLGVKLIVVLGHSGCGAVKAA 107
beta_CA_cladeC cd03378
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 32-95 1.04e-07

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 239473 [Multi-domain]  Cd Length: 154  Bit Score: 49.45  E-value: 1.04e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 13814411  32 ILTCMDERVHVEEALGIRPEDAHIYRNAGGIVTDDAIRSASLTTNFFGTKEIIVITHTDCGMIR 95
Cdd:cd03378  43 ILSCSDSRVPPEIIFDQGLGDLFVVRVAGNIVDDDVLGSLEYAVEVLGVPLVVVLGHESCGAVA 106
PRK15219 PRK15219
carbonic anhydrase; Provisional
 32-101 4.17e-05

carbonic anhydrase; Provisional


Pssm-ID: 237927 [Multi-domain]  Cd Length: 245  Bit Score: 42.90  E-value: 4.17e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13814411   32 ILTCMDERVHVEEALGIRPEDAHIYRNAGGIVTDDAIRSASLTTNFFGTKEIIVITHTDCGMIRFTGDEV 101
Cdd:PRK15219  94 ILSCIDSRAPAEIILDTGIGETFNSRVAGNISNDDLLGSMEFACAVAGAKVVLVMGHTACGAVKGAIDNV 163
beta_CA_cladeB cd00884
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 34-95 4.62e-05

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238449  Cd Length: 190  Bit Score: 42.53  E-value: 4.62e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13814411  34 TCMDERVHVEEALGIRPEDAHIYRNAGGIVTD-DAIRSASLTT-------NFFGTKEIIVITHTDCGMIR 95
Cdd:cd00884  32 ACSDSRVVPALITQTQPGELFVVRNVGNLVPPyEPDGGFHGTSaaieyavAVLKVEHIVVCGHSDCGGIR 101
beta_CA_cladeA cd00883
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 30-95 6.55e-04

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238448  Cd Length: 182  Bit Score: 39.09  E-value: 6.55e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13814411  30 LWIlTCMDERVHVEEALGIRPEDAHIYRNAGGIV--TDDAIRSaslTTNF----FGTKEIIVITHTDCGMIR 95
Cdd:cd00883  28 LWI-GCSDSRVPENTILGLLPGEVFVHRNIANLVspTDLNCLS---VLQYavdvLKVKHIIVCGHYGCGGVK 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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