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Conserved domains on  [gi|13699236|gb|AAK38369|]
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placental protein 18b [Homo sapiens]

Protein Classification

branched-chain amino acid aminotransferase( domain architecture ID 10107512)

branched-chain amino acid aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BCAT_beta_family cd01557
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the ...
 2-290 5.35e-125

BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate. The enzyme requires pyridoxal 5'-phosphate (PLP) as a cofactor to catalyze the reaction. It has been found that mammals have two foms of the enzyme - mitochondrial and cytosolic forms while bacteria contain only one form of the enzyme. The mitochondrial form plays a significant role in skeletal muscle glutamine and alanine synthesis and in interorgan nitrogen metabolism.Members of this subgroup are widely distributed in all three forms of life.


:

Pssm-ID: 238798  Cd Length: 279  Bit Score: 358.05  E-value: 5.35e-125
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236   2 AAAAL---GQLFEGMKAFKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVR 78
Cdd:cd01557   5 ATHALhygQAVFEGLKAYRTPDGKIVLFRPDENAERLNRSARRLGLPPFSVEEFIDAIKELVKLDADWVPYGGGASLYIR 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236  79 PVLIGNEPSLGVSQPTRALLFVILCPVGAYFPGGSvTPVSLLADPaFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGCE 158
Cdd:cd01557  85 PFIFGTDPQLGVSPALEYLFAVFASPVGAYFKGGE-KGVSALVSS-FRRAAPGGPGAAKAGGNYAASLLAQKEAAEKGYD 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236 159 QVLWLYGPDHQLTEVGTMNIFVYWtheDGvlELVTPPLNGVILPGVVRQSLLDMAQTWGeFRVVERTITMKQLLRALeeg 238
Cdd:cd01557 163 QALWLDGAHGYVAEVGTMNIFFVK---DG--ELITPPLDGSILPGITRDSILELARDLG-IKVEERPITRDELYEAD--- 233

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 13699236 239 rvrEVFGSGTACQVCPVHRILYKDRNlhiPTMENGPELILRFQKELKEIQYG 290
Cdd:cd01557 234 ---EVFATGTAAVVTPVGEIDYRGKE---PGEGEVGPVTKKLYDLLTDIQYG 279
 
Name Accession Description Interval E-value
BCAT_beta_family cd01557
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the ...
 2-290 5.35e-125

BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate. The enzyme requires pyridoxal 5'-phosphate (PLP) as a cofactor to catalyze the reaction. It has been found that mammals have two foms of the enzyme - mitochondrial and cytosolic forms while bacteria contain only one form of the enzyme. The mitochondrial form plays a significant role in skeletal muscle glutamine and alanine synthesis and in interorgan nitrogen metabolism.Members of this subgroup are widely distributed in all three forms of life.


Pssm-ID: 238798  Cd Length: 279  Bit Score: 358.05  E-value: 5.35e-125
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236   2 AAAAL---GQLFEGMKAFKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVR 78
Cdd:cd01557   5 ATHALhygQAVFEGLKAYRTPDGKIVLFRPDENAERLNRSARRLGLPPFSVEEFIDAIKELVKLDADWVPYGGGASLYIR 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236  79 PVLIGNEPSLGVSQPTRALLFVILCPVGAYFPGGSvTPVSLLADPaFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGCE 158
Cdd:cd01557  85 PFIFGTDPQLGVSPALEYLFAVFASPVGAYFKGGE-KGVSALVSS-FRRAAPGGPGAAKAGGNYAASLLAQKEAAEKGYD 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236 159 QVLWLYGPDHQLTEVGTMNIFVYWtheDGvlELVTPPLNGVILPGVVRQSLLDMAQTWGeFRVVERTITMKQLLRALeeg 238
Cdd:cd01557 163 QALWLDGAHGYVAEVGTMNIFFVK---DG--ELITPPLDGSILPGITRDSILELARDLG-IKVEERPITRDELYEAD--- 233

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 13699236 239 rvrEVFGSGTACQVCPVHRILYKDRNlhiPTMENGPELILRFQKELKEIQYG 290
Cdd:cd01557 234 ---EVFATGTAAVVTPVGEIDYRGKE---PGEGEVGPVTKKLYDLLTDIQYG 279
PRK13357 PRK13357
branched-chain amino acid aminotransferase; Provisional
 1-300 2.96e-102

branched-chain amino acid aminotransferase; Provisional


Pssm-ID: 237363  Cd Length: 356  Bit Score: 303.22  E-value: 2.96e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236    1 MAAAAL--GQ-LFEGMKAFKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAA-GTSLY 76
Cdd:PRK13357  57 PAATVLhyGQeIFEGLKAYRHKDGSIVLFRPDANAKRLQRSADRLLMPELPEELFLEAVKQLVKADRDWVPPYGeGASLY 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236   77 VRPVLIGNEPSLGVSQPTRALLFVILCPVGAYFPGGsVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRG 156
Cdd:PRK13357 137 LRPFMIATEPFLGVKPAEEYIFCVIASPVGAYFKGG-VKPVSIWVSDEYDRAAPGGTGAAKVGGNYAASLLAQAEAKEKG 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236  157 CEQVLWLYGPDHQ-LTEVGTMNIF-VYwthEDGVlelVTPPLNGVILPGVVRQSLLDMAQTWGeFRVVERTITMKQLLRA 234
Cdd:PRK13357 216 CDQVLYLDAVEHTyIEEVGGMNFFfIT---KDGT---VTPPLSGSILPGITRDSLLQLAEDLG-LTVEERPVSIDEWQAD 288

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13699236  235 LEEGRVREVFGSGTACQVCPVHRILYKDRNLHIPTMENGPeLILRFQKELKEIQYGIRA--HEWMFPV 300
Cdd:PRK13357 289 AASGEFTEAFACGTAAVITPIGGIKYKDKEFVIGDGEVGP-VTQKLYDELTGIQFGDVEdpHGWIVKV 355
ilvE_II TIGR01123
branched-chain amino acid aminotransferase, group II; Among the class IV aminotransferases are ...
 2-300 2.36e-80

branched-chain amino acid aminotransferase, group II; Among the class IV aminotransferases are two phylogenetically separable groups of branched-chain amino acid aminotransferase (IlvE). The last common ancestor of the two lineages appears also to have given rise to a family of D-amino acid aminotransferases (DAAT). This model represents the IlvE family less similar to the DAAT family. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 233278  Cd Length: 313  Bit Score: 245.82  E-value: 2.36e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236     2 AAAAL--GQ-LFEGMKAFKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDA-AGTSLYV 77
Cdd:TIGR01123  17 GSTVLhyGQeCFEGLKAYRCADGSIVLFRPDANAARLRRSARRLLMPELPDELFLEALRQLVKANKDWVPPYgSGASLYL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236    78 RPVLIGNEPSLGVSQPTRALLFVILCPVGAYFPGGsVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGC 157
Cdd:TIGR01123  97 RPFVIGTEPNLGVRPAPEYLFYVFASPVGAYFKGG-LAPVSIFVTTEYDRAAPGGTGAVKVGGNYAASLLAQAKAAEQGC 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236   158 EQVLWLYGPDHQ-LTEVGTMNIFVYWTheDGvlELVTPPLNGVILPGVVRQSLLDMAQTWGeFRVVERTITMKQLLRALE 236
Cdd:TIGR01123 176 DQVVYLDPVEHTyIEEVGAMNFFFITG--DG--ELVTPPLSGSILPGITRDSLLQLAKDLG-MEVEERRIDIDELKAFVE 250

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13699236   237 EGrvREVFGSGTACQVCPVHRILYKDRNLHIPTMENGpELILRFQKELKEIQYGIRA--HEWMFPV 300
Cdd:TIGR01123 251 AG--EIVFACGTAAVITPVGEIQHGGKEVVFASGQPG-EVTKALYDELTDIQYGDFEdpYGWIVEV 313
IlvE COG0115
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid ...
 9-290 3.44e-61

Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 439885 [Multi-domain]  Cd Length: 285  Bit Score: 195.79  E-value: 3.44e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236   9 LFEGMKAFKGkdqqvRLFRPWLNMDRMLRSAMRLCLP-SFDKLELLECIRRLIEVDKDwvpdaagTSLYVRPVLIGNEPS 87
Cdd:COG0115  30 VFEGIRAYDG-----RLFRLDEHLARLNRSAKRLGIPiPYTEEELLEAIRELVAANGL-------EDGYIRPQVTRGVGG 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236  88 LGVSQPT-RALLFVILCPVGAYFPGGSVTPVSLLADPaFIRAWVGGVGNYKlGGNYGPTVLVQQEALKRGCEQVLWLyGP 166
Cdd:COG0115  98 RGVFAEEyEPTVIIIASPLPAYPAEAYEKGVRVITSP-YRRAAPGGLGGIK-TGNYLNNVLAKQEAKEAGADEALLL-DT 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236 167 DHQLTEVGTMNIFVYwthEDGVLelVTPPLNGVILPGVVRQSLLDMAQTWGeFRVVERTITMKQLLRAleegrvREVFGS 246
Cdd:COG0115 175 DGYVAEGSGSNVFIV---KDGVL--VTPPLSGGILPGITRDSVIELARELG-IPVEERPISLEELYTA------DEVFLT 242

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 13699236 247 GTACQVCPVHRIlykdRNLHIPTMENGPeLILRFQKELKEIQYG 290
Cdd:COG0115 243 GTAAEVTPVTEI----DGRPIGDGKPGP-VTRRLRELYTDIVRG 281
Aminotran_4 pfam01063
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to ...
 8-258 7.65e-32

Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to catalyze the synthesis of D-glutamic acid and D-alanine, which are essential constituents of bacterial cell wall and are the building block for other D-amino acids. Despite the difference in the structure of the substrates, D-AATs and L-ATTs have strong similarity.


Pssm-ID: 395844 [Multi-domain]  Cd Length: 221  Bit Score: 117.84  E-value: 7.65e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236     8 QLFEGMKAFKGkdqqvRLFRPWLNMDRMLRSAMRLCLP-SFDKLELLECIRRLIEVDKDWVPdaagtslYVRPVLIGNEP 86
Cdd:pfam01063   1 GVFETLRVYNG-----KIFFLDEHLARLRRSAKLLGIPlPFDEEDLRKIIEELLKANGLGVG-------RLRLTVSRGPG 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236    87 SLGVSQPT-RALLFVILCPVGAYFPGGSVTPVSLLADPAFIRAwvggvgNYKlGGNYGPTVLVQQEALKRGCEQVLwLYG 165
Cdd:pfam01063  69 GFGLPTSDpTLAIFVSALPPPPESKKKGVISSLVRRNPPSPLP------GAK-TLNYLENVLARREAKAQGADDAL-LLD 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236   166 PDHQLTEVGTMNIFvyWTHEDgvlELVTPPLNGVILPGVVRQSLLDMAQTWGeFRVVERTITMKQLLRAleegrvREVFG 245
Cdd:pfam01063 141 EDGNVTEGSTSNVF--LVKGG---TLYTPPLESGILPGITRQALLDLAKALG-LEVEERPITLADLQEA------DEAFL 208

                         250
                  ....*....|...
gi 13699236   246 SGTACQVCPVHRI 258
Cdd:pfam01063 209 TNSLRGVTPVSSI 221
 
Name Accession Description Interval E-value
BCAT_beta_family cd01557
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the ...
 2-290 5.35e-125

BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate. The enzyme requires pyridoxal 5'-phosphate (PLP) as a cofactor to catalyze the reaction. It has been found that mammals have two foms of the enzyme - mitochondrial and cytosolic forms while bacteria contain only one form of the enzyme. The mitochondrial form plays a significant role in skeletal muscle glutamine and alanine synthesis and in interorgan nitrogen metabolism.Members of this subgroup are widely distributed in all three forms of life.


Pssm-ID: 238798  Cd Length: 279  Bit Score: 358.05  E-value: 5.35e-125
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236   2 AAAAL---GQLFEGMKAFKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVR 78
Cdd:cd01557   5 ATHALhygQAVFEGLKAYRTPDGKIVLFRPDENAERLNRSARRLGLPPFSVEEFIDAIKELVKLDADWVPYGGGASLYIR 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236  79 PVLIGNEPSLGVSQPTRALLFVILCPVGAYFPGGSvTPVSLLADPaFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGCE 158
Cdd:cd01557  85 PFIFGTDPQLGVSPALEYLFAVFASPVGAYFKGGE-KGVSALVSS-FRRAAPGGPGAAKAGGNYAASLLAQKEAAEKGYD 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236 159 QVLWLYGPDHQLTEVGTMNIFVYWtheDGvlELVTPPLNGVILPGVVRQSLLDMAQTWGeFRVVERTITMKQLLRALeeg 238
Cdd:cd01557 163 QALWLDGAHGYVAEVGTMNIFFVK---DG--ELITPPLDGSILPGITRDSILELARDLG-IKVEERPITRDELYEAD--- 233

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 13699236 239 rvrEVFGSGTACQVCPVHRILYKDRNlhiPTMENGPELILRFQKELKEIQYG 290
Cdd:cd01557 234 ---EVFATGTAAVVTPVGEIDYRGKE---PGEGEVGPVTKKLYDLLTDIQYG 279
PRK13357 PRK13357
branched-chain amino acid aminotransferase; Provisional
 1-300 2.96e-102

branched-chain amino acid aminotransferase; Provisional


Pssm-ID: 237363  Cd Length: 356  Bit Score: 303.22  E-value: 2.96e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236    1 MAAAAL--GQ-LFEGMKAFKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAA-GTSLY 76
Cdd:PRK13357  57 PAATVLhyGQeIFEGLKAYRHKDGSIVLFRPDANAKRLQRSADRLLMPELPEELFLEAVKQLVKADRDWVPPYGeGASLY 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236   77 VRPVLIGNEPSLGVSQPTRALLFVILCPVGAYFPGGsVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRG 156
Cdd:PRK13357 137 LRPFMIATEPFLGVKPAEEYIFCVIASPVGAYFKGG-VKPVSIWVSDEYDRAAPGGTGAAKVGGNYAASLLAQAEAKEKG 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236  157 CEQVLWLYGPDHQ-LTEVGTMNIF-VYwthEDGVlelVTPPLNGVILPGVVRQSLLDMAQTWGeFRVVERTITMKQLLRA 234
Cdd:PRK13357 216 CDQVLYLDAVEHTyIEEVGGMNFFfIT---KDGT---VTPPLSGSILPGITRDSLLQLAEDLG-LTVEERPVSIDEWQAD 288

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13699236  235 LEEGRVREVFGSGTACQVCPVHRILYKDRNLHIPTMENGPeLILRFQKELKEIQYGIRA--HEWMFPV 300
Cdd:PRK13357 289 AASGEFTEAFACGTAAVITPIGGIKYKDKEFVIGDGEVGP-VTQKLYDELTGIQFGDVEdpHGWIVKV 355
ilvE_II TIGR01123
branched-chain amino acid aminotransferase, group II; Among the class IV aminotransferases are ...
 2-300 2.36e-80

branched-chain amino acid aminotransferase, group II; Among the class IV aminotransferases are two phylogenetically separable groups of branched-chain amino acid aminotransferase (IlvE). The last common ancestor of the two lineages appears also to have given rise to a family of D-amino acid aminotransferases (DAAT). This model represents the IlvE family less similar to the DAAT family. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 233278  Cd Length: 313  Bit Score: 245.82  E-value: 2.36e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236     2 AAAAL--GQ-LFEGMKAFKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDA-AGTSLYV 77
Cdd:TIGR01123  17 GSTVLhyGQeCFEGLKAYRCADGSIVLFRPDANAARLRRSARRLLMPELPDELFLEALRQLVKANKDWVPPYgSGASLYL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236    78 RPVLIGNEPSLGVSQPTRALLFVILCPVGAYFPGGsVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGC 157
Cdd:TIGR01123  97 RPFVIGTEPNLGVRPAPEYLFYVFASPVGAYFKGG-LAPVSIFVTTEYDRAAPGGTGAVKVGGNYAASLLAQAKAAEQGC 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236   158 EQVLWLYGPDHQ-LTEVGTMNIFVYWTheDGvlELVTPPLNGVILPGVVRQSLLDMAQTWGeFRVVERTITMKQLLRALE 236
Cdd:TIGR01123 176 DQVVYLDPVEHTyIEEVGAMNFFFITG--DG--ELVTPPLSGSILPGITRDSLLQLAKDLG-MEVEERRIDIDELKAFVE 250

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13699236   237 EGrvREVFGSGTACQVCPVHRILYKDRNLHIPTMENGpELILRFQKELKEIQYGIRA--HEWMFPV 300
Cdd:TIGR01123 251 AG--EIVFACGTAAVITPVGEIQHGGKEVVFASGQPG-EVTKALYDELTDIQYGDFEdpYGWIVEV 313
PLPDE_IV cd00449
PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, ...
 8-284 1.63e-76

PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate lyases (ADCL). BCAT catalyzes the reversible transamination reaction between the L-branched-chain amino and alpha-keto acids. DAAT catalyzes the synthesis of D-glutamic acid and D-alanine, and ADCL converts 4-amino-4-deoxychorismate to p-aminobenzoate and pyruvate. Except for a few enzymes, i. e., Escherichia coli and Salmonella BCATs, which are homohexamers arranged as a double trimer, the class IV PLPDEs are homodimers. Homodimer formation is required for catalytic activity.


Pssm-ID: 238254 [Multi-domain]  Cd Length: 256  Bit Score: 234.03  E-value: 1.63e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236   8 QLFEGMKAFKGkdqqvRLFRPWLNMDRMLRSAMRLCLP-SFDKLELLECIRRLIEVDKdwvpdaaGTSLYVRPVLIGNEP 86
Cdd:cd00449   9 GVFEGLRAGKG-----RLFRLDEHLDRLNRSAKRLGLPiPYDREELREALKELVAANN-------GASLYIRPLLTRGVG 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236  87 SLGVSQP--TRALLFVILCPVGAYFPGGSvTPVSLLADPAFIRAWVGGVGNYKLGGNYgPTVLVQQEALKRGCEQVLWLY 164
Cdd:cd00449  77 GLGVAPPpsPEPTFVVFASPVGAYAKGGE-KGVRLITSPDRRRAAPGGTGDAKTGGNL-NSVLAKQEAAEAGADEALLLD 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236 165 GpDHQLTEVGTMNIFVYWtheDGvlELVTPPLNGVILPGVVRQSLLDMAQTWGeFRVVERTITMKQLLRAleegrvREVF 244
Cdd:cd00449 155 D-NGYVTEGSASNVFIVK---DG--ELVTPPLDGGILPGITRDSVIELAKELG-IKVEERPISLDELYAA------DEVF 221

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 13699236 245 GSGTACQVCPVHRILYKDRnlhipTMENGPELILRFQKEL 284
Cdd:cd00449 222 LTGTAAEVTPVTEIDGRGI-----GDGKPGPVTRKLRELL 256
IlvE COG0115
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid ...
 9-290 3.44e-61

Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 439885 [Multi-domain]  Cd Length: 285  Bit Score: 195.79  E-value: 3.44e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236   9 LFEGMKAFKGkdqqvRLFRPWLNMDRMLRSAMRLCLP-SFDKLELLECIRRLIEVDKDwvpdaagTSLYVRPVLIGNEPS 87
Cdd:COG0115  30 VFEGIRAYDG-----RLFRLDEHLARLNRSAKRLGIPiPYTEEELLEAIRELVAANGL-------EDGYIRPQVTRGVGG 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236  88 LGVSQPT-RALLFVILCPVGAYFPGGSVTPVSLLADPaFIRAWVGGVGNYKlGGNYGPTVLVQQEALKRGCEQVLWLyGP 166
Cdd:COG0115  98 RGVFAEEyEPTVIIIASPLPAYPAEAYEKGVRVITSP-YRRAAPGGLGGIK-TGNYLNNVLAKQEAKEAGADEALLL-DT 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236 167 DHQLTEVGTMNIFVYwthEDGVLelVTPPLNGVILPGVVRQSLLDMAQTWGeFRVVERTITMKQLLRAleegrvREVFGS 246
Cdd:COG0115 175 DGYVAEGSGSNVFIV---KDGVL--VTPPLSGGILPGITRDSVIELARELG-IPVEERPISLEELYTA------DEVFLT 242

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 13699236 247 GTACQVCPVHRIlykdRNLHIPTMENGPeLILRFQKELKEIQYG 290
Cdd:COG0115 243 GTAAEVTPVTEI----DGRPIGDGKPGP-VTRRLRELYTDIVRG 281
PLN02782 PLN02782
Branched-chain amino acid aminotransferase
 7-263 1.80e-50

Branched-chain amino acid aminotransferase


Pssm-ID: 215418  Cd Length: 403  Bit Score: 171.57  E-value: 1.80e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236    7 GQ-LFEGMKAFKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNE 85
Cdd:PLN02782 119 GQgLFEGLKAYRKEDGNILLFRPEENAIRMRNGAERMCMPAPTVEQFVEAVKETVLANKRWVPPPGKGSLYIRPLLMGSG 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236   86 PSLGVSqPTRALLFVI-LCPVGAYFPGGsVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGCEQVLWLy 164
Cdd:PLN02782 199 AVLGLA-PAPEYTFLIyVSPVGNYFKEG-VAPINLIVENEFHRATPGGTGGVKTIGNYAAVLKAQSIAKAKGYSDVLYL- 275

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236  165 gpD--HQ--LTEVGTMNIFVYwthEDGVLElvTPPLNGVILPGVVRQSLLDMAQTWGeFRVVERTITMKQLLRAleegrv 240
Cdd:PLN02782 276 --DcvHKkyLEEVSSCNIFIV---KDNVIS--TPAIKGTILPGITRKSIIDVARSQG-FQVEERNVTVDELLEA------ 341

                        250       260
                 ....*....|....*....|...
gi 13699236  241 REVFGSGTACQVCPVHRILYKDR 263
Cdd:PLN02782 342 DEVFCTGTAVVVSPVGSITYKGK 364
PLN03117 PLN03117
Branched-chain-amino-acid aminotransferase; Provisional
 7-291 2.62e-45

Branched-chain-amino-acid aminotransferase; Provisional


Pssm-ID: 178664  Cd Length: 355  Bit Score: 157.02  E-value: 2.62e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236    7 GQ-LFEGMKAFKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNE 85
Cdd:PLN03117  69 GQgLFEGLKAYRTEDGRITLFRPDQNALRMQTGADRLCMTPPSLEQFVEAVKQTVLANKKWVPPPGKGTLYIRPLLIGSG 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236   86 PSLGVSQPTRALLFVILCPVGAYFPGGSvtPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGCEQVLWL-Y 164
Cdd:PLN03117 149 AVLGVAPAPEYTFLIYASPVGNYHKASS--GLNLKVDHKHRRAHSGGTGGVKSCTNYSPVVKSLIEAKSSGFSDVLFLdA 226

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236  165 GPDHQLTEVGTMNIFVYwthEDGVLElvTPPLNGVILPGVVRQSLLDMAQTWGeFRVVERTITMKQLLRAleegrvREVF 244
Cdd:PLN03117 227 ATGKNIEELSACNIFIL---KGNIVS--TPPTSGTILPGVTRKSISELARDIG-YQVEERDVSVDELLEA------EEVF 294

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 13699236  245 GSGTACQVCPVHRILYKDRNLHIPTMENGpeLILRFQKELKEIQYGI 291
Cdd:PLN03117 295 CTGTAVVVKAVETVTFHDKKVKYRTGEEA--LSTKLHLILTNIQMGV 339
PLN02883 PLN02883
Branched-chain amino acid aminotransferase
 9-262 1.67e-42

Branched-chain amino acid aminotransferase


Pssm-ID: 178471  Cd Length: 384  Bit Score: 150.25  E-value: 1.67e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236    9 LFEGMKAFKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSL 88
Cdd:PLN02883 104 LIEGMKAYRGEDGRILLFRPELNAMRMKIGAERMCMHSPSVHQFIEGVKQTVLANRRWVPPPGKGSLYLRPLLFGSGASL 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236   89 GVSQPTRALLFVILCPVGAYFPGGSVTpVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGCEQVLWLYG-PD 167
Cdd:PLN02883 184 GVAAAPEYTFLVFGSPVQNYFKEGTAA-LNLYVEEVIPRAYLGGTGGVKAISNYGPVLEVMRRAKSRGFSDVLYLDAdTG 262

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236  168 HQLTEVGTMNIFVYWTHedgvlELVTPPLNGVILPGVVRQSLLDMAQTWGeFRVVERTITMKQLLRAleegrvREVFGSG 247
Cdd:PLN02883 263 KNIEEVSAANIFLVKGN-----IIVTPATSGTILGGITRKSIIEIALDLG-YKVEERRVPVEELKEA------EEVFCTG 330

                        250
                 ....*....|....*
gi 13699236  248 TACQVCPVHRILYKD 262
Cdd:PLN02883 331 TAAGVASVGSITFKN 345
PLN02259 PLN02259
branched-chain-amino-acid aminotransferase 2
 9-291 1.02e-37

branched-chain-amino-acid aminotransferase 2


Pssm-ID: 177901  Cd Length: 388  Bit Score: 137.55  E-value: 1.02e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236    9 LFEGMKAFKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSL 88
Cdd:PLN02259 108 IYEGTKAYRKENGKLLLFRPDHNAIRMKLGAERMLMPSPSVDQFVNAVKQTALANKRWVPPAGKGTLYIRPLLMGSGPIL 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236   89 GVSQPTRALLFVILCPVGAYFPGGsVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGCEQVLWLYGPDH 168
Cdd:PLN02259 188 GLGPAPEYTFIVYASPVGNYFKEG-MAALNLYVEEEYVRAAPGGAGGVKSITNYAPVLKALSRAKSRGFSDVLYLDSVKK 266

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236  169 Q-LTEVGTMNIFVYWTHedgvlELVTPPLNGVILPGVVRQSLLDMAQTWGeFRVVERTITMKQLLRAleegrvREVFGSG 247
Cdd:PLN02259 267 KyLEEASSCNVFVVKGR-----TISTPATNGTILEGITRKSVMEIASDQG-YQVVEKAVHVDEVMDA------DEVFCTG 334

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 13699236  248 TACQVCPVHRILYKDRNLHIPTMENgpELILRFQKELKEIQYGI 291
Cdd:PLN02259 335 TAVVVAPVGTITYQEKRVEYKTGDE--SVCQKLRSVLVGIQTGL 376
Aminotran_4 pfam01063
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to ...
 8-258 7.65e-32

Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to catalyze the synthesis of D-glutamic acid and D-alanine, which are essential constituents of bacterial cell wall and are the building block for other D-amino acids. Despite the difference in the structure of the substrates, D-AATs and L-ATTs have strong similarity.


Pssm-ID: 395844 [Multi-domain]  Cd Length: 221  Bit Score: 117.84  E-value: 7.65e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236     8 QLFEGMKAFKGkdqqvRLFRPWLNMDRMLRSAMRLCLP-SFDKLELLECIRRLIEVDKDWVPdaagtslYVRPVLIGNEP 86
Cdd:pfam01063   1 GVFETLRVYNG-----KIFFLDEHLARLRRSAKLLGIPlPFDEEDLRKIIEELLKANGLGVG-------RLRLTVSRGPG 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236    87 SLGVSQPT-RALLFVILCPVGAYFPGGSVTPVSLLADPAFIRAwvggvgNYKlGGNYGPTVLVQQEALKRGCEQVLwLYG 165
Cdd:pfam01063  69 GFGLPTSDpTLAIFVSALPPPPESKKKGVISSLVRRNPPSPLP------GAK-TLNYLENVLARREAKAQGADDAL-LLD 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236   166 PDHQLTEVGTMNIFvyWTHEDgvlELVTPPLNGVILPGVVRQSLLDMAQTWGeFRVVERTITMKQLLRAleegrvREVFG 245
Cdd:pfam01063 141 EDGNVTEGSTSNVF--LVKGG---TLYTPPLESGILPGITRQALLDLAKALG-LEVEERPITLADLQEA------DEAFL 208

                         250
                  ....*....|...
gi 13699236   246 SGTACQVCPVHRI 258
Cdd:pfam01063 209 TNSLRGVTPVSSI 221
ilvE_I TIGR01122
branched-chain amino acid aminotransferase, group I; Among the class IV aminotransferases are ...
 10-300 1.86e-22

branched-chain amino acid aminotransferase, group I; Among the class IV aminotransferases are two phylogenetically separable groups of branched-chain amino acid aminotransferase (IlvE). The last common ancestor of the two lineages appears also to have given rise to a family of D-amino acid aminotransferases (DAAT). This model represents the IlvE family more strongly similar to the DAAT family. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 130192  Cd Length: 298  Bit Score: 94.73  E-value: 1.86e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236    10 FEGMKAFKGkDQQVRLFRPWLNMDRMLRSAMRLCLP-SFDKLELLECIRRLIEVDKDwvpdaagTSLYVRPVLIGNEPSL 88
Cdd:TIGR01122  28 FEGIRAYDT-DKGPAIFRLKEHIQRLYDSAKIYRMEiPYSKEELMEATRETLRKNNL-------RSAYIRPLVFRGDGDL 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236    89 GVSQP--TRALLFVILCPVGAYfpggsvtpvslLADPAF---IRAWVGGV---------GNYKLGGNYGPTVLVQQEALK 154
Cdd:TIGR01122 100 GLNPRagYKPDVIIAAWPWGAY-----------LGEEALekgIDAKVSSWrrnapntipTAAKAGGNYLNSLLAKSEARR 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236   155 RGCEQVLWLyGPDHQLTEVGTMNIFVYwthEDGVLelVTPPLNGVILPGVVRQSLLDMAQTWGeFRVVERTITMKQLLRA 234
Cdd:TIGR01122 169 HGYDEAILL-DVEGYVAEGSGENIFIV---KDGVL--FTPPVTSSILPGITRDTVITLAKELG-IEVVEQPISREELYTA 241

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13699236   235 leegrvREVFGSGTACQVCPVHRIlykdRNLHIPTMENGPeLILRFQKELKEIQYG-IRAH-EWMFPV 300
Cdd:TIGR01122 242 ------DEAFFTGTAAEITPIREV----DGRKIGNGRRGP-VTKKLQEAFFDLVTGgTEDYwGWLTYV 298
PRK06606 PRK06606
branched-chain amino acid transaminase;
10-258 3.59e-20

branched-chain amino acid transaminase;


Pssm-ID: 235841  Cd Length: 306  Bit Score: 88.28  E-value: 3.59e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236   10 FEGMKAFKGKDQQVrLFRPWLNMDRMLRSA--MRLCLPsFDKLELLECIRRLIEVDKdwvPDAAgtslYVRP-VLIGNEp 86
Cdd:PRK06606  37 FEGIRAYDTPKGPA-IFRLREHTKRLFNSAkiLRMEIP-YSVDELMEAQREVVRKNN---LKSA----YIRPlVFVGDE- 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236   87 SLGVSQ---PTRALLFVIlcPVGAYFPGGS------------------VTPVslladpafiRAwvggvgnyKLGGNYGPT 145
Cdd:PRK06606 107 GLGVRPhglPTDVAIAAW--PWGAYLGEEAlekgirvkvsswtrhapnSIPT---------RA--------KASGNYLNS 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236  146 VLVQQEALKRGCEQVLWLyGPDHQLTEVGTMNIFVYwthEDGVleLVTPPLNGVILPGVVRQSLLDMAQTWGeFRVVERT 225
Cdd:PRK06606 168 ILAKTEARRNGYDEALLL-DVEGYVSEGSGENIFIV---RDGV--LYTPPLTSSILEGITRDTVITLAKDLG-IEVIERR 240

                        250       260       270
                 ....*....|....*....|....*....|...
gi 13699236  226 ITMKQLLRAleegrvREVFGSGTACQVCPVHRI 258
Cdd:PRK06606 241 ITRDELYIA------DEVFFTGTAAEVTPIREV 267
D-AAT_like cd01558
D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes ...
 10-258 1.45e-18

D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and D-glutamate in addition to other D-amino acids. The enzyme like other members of this superfamily requires PLP as a cofactor. Members of this subgroup are found in all three forms of life.


Pssm-ID: 238799 [Multi-domain]  Cd Length: 270  Bit Score: 83.42  E-value: 1.45e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236  10 FEGMKAFKGKdqqvrLFRPWLNMDRMLRSAMRLCLPS-FDKLELLECIRRLIEvdKDWVPDAAGtslYVRpVLIGNEP-S 87
Cdd:cd01558  28 YEVIRVYNGK-----PFALDEHLDRLYRSAKELRIDIpYTREELKELIRELVA--KNEGGEGDV---YIQ-VTRGVGPrG 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236  88 LGVSQPTRALLFVILCPVGAYFPGGSVTPVSLLADPaFIRaWvgGVGNYKLGgNYGPTVLVQQEALKRGCEQVlWLYGPD 167
Cdd:cd01558  97 HDFPKCVKPTVVIITQPLPLPPAELLEKGVRVITVP-DIR-W--LRCDIKSL-NLLNNVLAKQEAKEAGADEA-ILLDAD 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236 168 HQLTEVGTMNIFVYwthEDGVLelVTPPLNGVILPGVVRQSLLDMAQTWGeFRVVERTITMKQLLRAleegrvREVFGSG 247
Cdd:cd01558 171 GLVTEGSSSNVFIV---KNGVL--VTPPLDNGILPGITRATVIELAKELG-IPVEERPFSLEELYTA------DEVFLTS 238

                       250
                ....*....|.
gi 13699236 248 TACQVCPVHRI 258
Cdd:cd01558 239 TTAEVMPVVEI 249
ADCL_like cd01559
ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent ...
 9-258 4.59e-15

ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most members of this subgroup are likely to function as dimers. The enzyme from E.Coli, the structure of which is available, is a homodimer that is folded into a small and a larger domain. The coenzyme pyridoxal 5; -phosphate resides at the interface of the two domains that is linked by a flexible loop. Members of this subgroup are found in Eukaryotes and bacteria.


Pssm-ID: 238800 [Multi-domain]  Cd Length: 249  Bit Score: 73.11  E-value: 4.59e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236   9 LFEGMKAFKGkdqQVRLFRPWLnmDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKdwVPDAAGTSLYVRPVLIGNEPSL 88
Cdd:cd01559  10 VFETMRALDG---RLFLLDAHL--ARLERSARRLGIPEPDLPRLRAALESLLAAND--IDEGRIRLILSRGPGGRGYAPS 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236  89 GVSQPTRaLLFVILCPVGAYFPGGSV--TPVSLLADPAFIRAwvggvgnyKlGGNYGPTVLVQQEALKRGCEQVLWLYGP 166
Cdd:cd01559  83 VCPGPAL-YVSVIPLPPAWRQDGVRLitCPVRLGEQPLLAGL--------K-HLNYLENVLAKREARDRGADEALFLDTD 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236 167 DHqLTEVGTMNIFvyWTHeDGvlELVTPPLNGVILPGVVRQSLLDMAQTWGEfRVVERTITMKQLLRAleegrvREVFGS 246
Cdd:cd01559 153 GR-VIEGTASNLF--FVK-DG--ELVTPSLDRGGLAGITRQRVIELAAAKGY-AVDERPLRLEDLLAA------DEAFLT 219

                       250
                ....*....|..
gi 13699236 247 GTACQVCPVHRI 258
Cdd:cd01559 220 NSLLGVAPVTAI 231
PRK08320 PRK08320
branched-chain amino acid aminotransferase; Reviewed
 10-258 6.63e-10

branched-chain amino acid aminotransferase; Reviewed


Pssm-ID: 236238 [Multi-domain]  Cd Length: 288  Bit Score: 58.73  E-value: 6.63e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236   10 FEGMKAFKGkdqqvRLFRPWLNMDRMLRSAMRLCL-PSFDKLELLECIrrlIE-VDKDWVPDAagtslYVRPVLIGNEPS 87
Cdd:PRK08320  33 FEGIRAYNG-----RVFRLKEHIDRLYDSAKAIMLeIPLSKEEMTEIV---LEtLRKNNLRDA-----YIRLVVSRGVGD 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236   88 LGV-----SQPTralLFVILCPVGAYFP-----GGSVTPVSlladpafIRAWVGGVGNYKLGG-NYGPTVLVQQEALKRG 156
Cdd:PRK08320 100 LGLdprkcPKPT---VVCIAEPIGLYPGelyekGLKVITVS-------TRRNRPDALSPQVKSlNYLNNILAKIEANLAG 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236  157 CEQVLWLygpDHQ--LTEVGTMNIFVYwthEDGVLelVTPPLNGVILPGVVRQSLLDMAQTWGeFRVVERTITMKQLLRA 234
Cdd:PRK08320 170 VDEAIML---NDEgyVAEGTGDNIFIV---KNGKL--ITPPTYAGALEGITRNAVIEIAKELG-IPVREELFTLHDLYTA 240

                        250       260
                 ....*....|....*....|....
gi 13699236  235 leegrvREVFGSGTACQVCPVHRI 258
Cdd:PRK08320 241 ------DEVFLTGTAAEVIPVVKV 258
PRK13356 PRK13356
branched-chain amino acid aminotransferase;
10-265 4.68e-07

branched-chain amino acid aminotransferase;


Pssm-ID: 237362  Cd Length: 286  Bit Score: 50.34  E-value: 4.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236   10 FEGMKAFKGKdqqvrlfRPWLNM--DRMLRSAMRLCL-PSFDKLEL----LECIRRLievdkdwvpdAAGTSLYVRPVLI 82
Cdd:PRK13356  37 FDGARAFEGV-------TPDLDLhcARVNRSAEALGLkPTVSAEEIealaREGLKRF----------DPDTALYIRPMYW 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236   83 GNEPSLGVSQP----TRALLFVILCPVGAyfPGGSVTPVSlladpAFIRAWVG-GVGNYKLGGNYGPTVLVQQEALKRGC 157
Cdd:PRK13356 100 AEDGFASGVAPdpesTRFALCLEEAPMPE--PTGFSLTLS-----PFRRPTLEmAPTDAKAGCLYPNNARALREARSRGF 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236  158 EQVLWLYGPDHqLTEVGTMNIFVYwthEDGVleLVTPPLNGVILPGVVRQSLLDMAQTWGeFRVVERTITMKQLLRAlee 237
Cdd:PRK13356 173 DNALVLDMLGN-VAETATSNVFMV---KDGV--VFTPVPNGTFLNGITRQRVIALLREDG-VTVVETTLTYEDFLEA--- 242

                        250       260
                 ....*....|....*....|....*...
gi 13699236  238 grvREVFGSGTACQVCPVHRIlyKDRNL 265
Cdd:PRK13356 243 ---DEVFSTGNYSKVVPVTRF--DDRSL 265
PRK06680 PRK06680
D-amino acid aminotransferase; Reviewed
 144-258 5.46e-06

D-amino acid aminotransferase; Reviewed


Pssm-ID: 180656 [Multi-domain]  Cd Length: 286  Bit Score: 46.85  E-value: 5.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236  144 PTVLVQQEALKRGCeQVLWLYGpDHQLTEVGTMNIFVywTHEDGVLelVTPPLNGVILPGVVRQSLLDMAQTWGeFRVVE 223
Cdd:PRK06680 155 PNVLAKQAAKEAGA-QEAWMVD-DGFVTEGASSNAWI--VTKDGKL--VTRPADNFILPGITRHTLIDLAKELG-LEVEE 227

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 13699236  224 RTITMKQLLRAleegrvREVFGSGTACQVCPVHRI 258
Cdd:PRK06680 228 RPFTLQEAYAA------REAFITAASSFVFPVVQI 256
PRK07544 PRK07544
branched-chain amino acid aminotransferase; Validated
 10-258 5.72e-06

branched-chain amino acid aminotransferase; Validated


Pssm-ID: 181025  Cd Length: 292  Bit Score: 46.89  E-value: 5.72e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236   10 FEGMKAFKGKdqqvrLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIeVDKDWVPDAagtslYVRPVLIGNEPSLG 89
Cdd:PRK07544  39 FEGERAYGGK-----IFKLREHSERLRRSAELLDFEIPYSVAEIDAAKKET-LAANGLTDA-----YVRPVAWRGSEMMG 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236   90 VS-QPTRALLFVILCPVGAYF-PGGSVTPVSL-LA-----DPAFIRAwvggvgNYKLGGNYGPTVLVQQEALKRGCEQVL 161
Cdd:PRK07544 108 VSaQQNKIHLAIAAWEWPSYFdPEAKMKGIRLdIAkwrrpDPETAPS------AAKAAGLYMICTISKHAAEAKGYADAL 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236  162 WLygpDH--QLTEVGTMNIFVYwthEDGVLELVTPplnGVILPGVVRQSLLDMAQTWGeFRVVERTItmkqllRALEEGR 239
Cdd:PRK07544 182 ML---DYrgYVAEATGANIFFV---KDGVIHTPTP---DCFLDGITRQTVIELAKRRG-IEVVERHI------MPEELAG 245

                        250
                 ....*....|....*....
gi 13699236  240 VREVFGSGTACQVCPVHRI 258
Cdd:PRK07544 246 FSECFLTGTAAEVTPVSEI 264
PRK12400 PRK12400
D-amino acid aminotransferase; Reviewed
 141-255 9.75e-05

D-amino acid aminotransferase; Reviewed


Pssm-ID: 171470  Cd Length: 290  Bit Score: 43.08  E-value: 9.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236  141 NYGPTVLVQQEALKRGCEQVLWLYgpDHQLTEVGTMNIFVYwthEDGVLelVTPPLNGVILPGVVRQSLLDMAQTWgEFR 220
Cdd:PRK12400 154 NLLPNILAATKAERKGCKEALFVR--NGTVTEGSHSNFFLI---KNGTL--YTHPANHLILNGIIRQYVLSLAKTL-RIP 225

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 13699236  221 VVERTITMKQLLRAleegrvREVFGSGTACQVCPV 255
Cdd:PRK12400 226 VQEELFSVRDVYQA------DECFFTGTTIEILPM 254
PRK12479 PRK12479
branched-chain-amino-acid transaminase;
141-258 7.61e-04

branched-chain-amino-acid transaminase;


Pssm-ID: 183549 [Multi-domain]  Cd Length: 299  Bit Score: 40.32  E-value: 7.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236  141 NYGPTVLVQQEALKRGCEQVLWLyGPDHQLTEVGTMNIFVYwthEDGvlELVTPPLNGVILPGVVRQSLLDMAQTWGeFR 220
Cdd:PRK12479 155 NYLNNVLVKIEAAQAGVLEALML-NQQGYVCEGSGDNVFVV---KDG--KVLTPPSYLGALEGITRNSVIELCERLS-IP 227

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 13699236  221 VVERTITMKQLLRAleegrvREVFGSGTACQVCPVHRI 258
Cdd:PRK12479 228 CEERPFTRHDVYVA------DEVFLTGTAAELIPVVKV 259
PLN02845 PLN02845
Branched-chain-amino-acid aminotransferase-like protein
 141-236 1.26e-03

Branched-chain-amino-acid aminotransferase-like protein


Pssm-ID: 215454 [Multi-domain]  Cd Length: 336  Bit Score: 40.00  E-value: 1.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236  141 NYGPTVLVQQEALKRGCEQVLWLYGpDHQLTEVGTMNI-FVywTHEDgvlELVTPPLNGvILPGVVRQSLLDMAQTW--- 216
Cdd:PLN02845 188 NYLPNALSQMEAEERGAFAGIWLDE-EGFVAEGPNMNVaFL--TNDG---ELVLPPFDK-ILSGCTARRVLELAPRLvsp 260

                         90       100
                 ....*....|....*....|.
gi 13699236  217 GEFRVVE-RTITMKQLLRALE 236
Cdd:PLN02845 261 GDLRGVKqRKISVEEAKAADE 281
PRK07849 PRK07849
aminodeoxychorismate lyase;
10-234 2.18e-03

aminodeoxychorismate lyase;


Pssm-ID: 236114 [Multi-domain]  Cd Length: 292  Bit Score: 39.17  E-value: 2.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236   10 FEGMKAFKGKdqqVRLFRPWLnmDRMLRSAMRLCLPSFDklelLECIRRLIE-VDKDWVPDAAGTSL---YVRpvliGNE 85
Cdd:PRK07849  42 FETLLVRDGR---PCNLEAHL--ERLARSAALLDLPEPD----LDRWRRAVElAIEEWRAPEDEAALrlvYSR----GRE 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236   86 pslGVSQPTralLFVILCPVGAYFPGGSVTPVSLLADPafiRAWVGGVGN---YKLGG----NYGPTVLVQQEALKRGCE 158
Cdd:PRK07849 109 ---SGGAPT---AWVTVSPVPERVARARREGVSVITLD---RGYPSDAAErapWLLAGaktlSYAVNMAALRYAARRGAD 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13699236  159 QVlwlygpdhqltevgtmnIFvywTHEDG-VLE-------------LVTPPLNGVILPGVVRQSLLDMAQTWGeFRVVER 224
Cdd:PRK07849 180 DV-----------------IF---TSTDGyVLEgptstvviatddrLLTPPPWYGILPGTTQAALFEVAREKG-WDCEYR 238

                        250
                 ....*....|
gi 13699236  225 TITMKQLLRA 234
Cdd:PRK07849 239 ALRPADLFAA 248
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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