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Conserved domains on  [gi|183986298|gb|AAI66590|]
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Fbxw9 protein [Rattus norvegicus]

Protein Classification

F-box/WD repeat-containing protein( domain architecture ID 1903488)

F-box/WD repeat-containing protein functions as the substrate-recognition component of an SCF (Skp1-Cullin-F-box protein) ubiquitin-protein ligase that is involved in ubiquitin-dependent degradation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
F-box_SF super family cl45894
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 87-123 1.92e-11

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


The actual alignment was detected with superfamily member cd22135:

Pssm-ID: 459239  Cd Length: 45  Bit Score: 57.67  E-value: 1.92e-11
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 183986298  87 LLEICAYLDARVVLHVLPCVCQALHNLVRDRVTWRLR 123
Cdd:cd22135    9 LLHICSYLDARFVLHVLPLVCKTFRDILSDETTWRIR 45
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 171-260 7.12e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 61.20  E-value: 7.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 183986298 171 GHFASIDAVLLLQGGTLCLSGSRDRNVNLWDLRhlGKEPSRVLVkalgtqgnsTHKGWVWSLAAQDHR--VCSGSWDSTV 248
Cdd:cd00200   49 GHTGPVRDVAASADGTYLASGSSDKTIRLWDLE--TGECVRTLT---------GHTSYVSSVAFSPDGriLSSSSRDKTI 117

                         90
                 ....*....|..
gi 183986298 249 KLWDMAADGQQF 260
Cdd:cd00200  118 KVWDVETGKCLT 129
 
Name Accession Description Interval E-value
F-box_FBXW9 cd22135
F-box domain found in F-box/WD repeat-containing protein 9 (FBXW9) and similar proteins; FBXW9, ...
 87-123 1.92e-11

F-box domain found in F-box/WD repeat-containing protein 9 (FBXW9) and similar proteins; FBXW9, also called F-box and WD-40 domain-containing protein 9, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438907  Cd Length: 45  Bit Score: 57.67  E-value: 1.92e-11
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 183986298  87 LLEICAYLDARVVLHVLPCVCQALHNLVRDRVTWRLR 123
Cdd:cd22135    9 LLHICSYLDARFVLHVLPLVCKTFRDILSDETTWRIR 45
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 171-260 7.12e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 61.20  E-value: 7.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 183986298 171 GHFASIDAVLLLQGGTLCLSGSRDRNVNLWDLRhlGKEPSRVLVkalgtqgnsTHKGWVWSLAAQDHR--VCSGSWDSTV 248
Cdd:cd00200   49 GHTGPVRDVAASADGTYLASGSSDKTIRLWDLE--TGECVRTLT---------GHTSYVSSVAFSPDGriLSSSSRDKTI 117

                         90
                 ....*....|..
gi 183986298 249 KLWDMAADGQQF 260
Cdd:cd00200  118 KVWDVETGKCLT 129
WD40 COG2319
WD40 repeat [General function prediction only];
170-254 1.92e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 57.61  E-value: 1.92e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 183986298 170 DGHFASIDAVLLLQGGTLCLSGSRDRNVNLWDLRhlGKEPSRVLvkalgtqgnSTHKGWVWSLA--AQDHRVCSGSWDST 247
Cdd:COG2319  327 TGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA--TGELLRTL---------TGHTGAVTSVAfsPDGRTLASGSADGT 395


                 ....*..
gi 183986298 248 VKLWDMA 254
Cdd:COG2319  396 VRLWDLA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 225-252 1.10e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.10e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 183986298   225 HKGWVWSLA--AQDHRVCSGSWDSTVKLWD 252
Cdd:smart00320  11 HTGPVTSVAfsPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
225-252 2.08e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 2.08e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 183986298  225 HKGWVWSLA--AQDHRVCSGSWDSTVKLWD 252
Cdd:pfam00400  10 HTGSVTSLAfsPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
F-box_FBXW9 cd22135
F-box domain found in F-box/WD repeat-containing protein 9 (FBXW9) and similar proteins; FBXW9, ...
 87-123 1.92e-11

F-box domain found in F-box/WD repeat-containing protein 9 (FBXW9) and similar proteins; FBXW9, also called F-box and WD-40 domain-containing protein 9, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438907  Cd Length: 45  Bit Score: 57.67  E-value: 1.92e-11
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 183986298  87 LLEICAYLDARVVLHVLPCVCQALHNLVRDRVTWRLR 123
Cdd:cd22135    9 LLHICSYLDARFVLHVLPLVCKTFRDILSDETTWRIR 45
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 171-260 7.12e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 61.20  E-value: 7.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 183986298 171 GHFASIDAVLLLQGGTLCLSGSRDRNVNLWDLRhlGKEPSRVLVkalgtqgnsTHKGWVWSLAAQDHR--VCSGSWDSTV 248
Cdd:cd00200   49 GHTGPVRDVAASADGTYLASGSSDKTIRLWDLE--TGECVRTLT---------GHTSYVSSVAFSPDGriLSSSSRDKTI 117

                         90
                 ....*....|..
gi 183986298 249 KLWDMAADGQQF 260
Cdd:cd00200  118 KVWDVETGKCLT 129
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 171-252 1.41e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.43  E-value: 1.41e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 183986298 171 GHFASIDAVLLLQGGTLCLSGSRDRNVNLWDLRHlgKEPSRVLVKalgtqgnstHKGWVWSLAAQDH--RVCSGSWDSTV 248
Cdd:cd00200  217 GHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRT--GECVQTLSG---------HTNSVTSLAWSPDgkRLASGSADGTI 285


                 ....
gi 183986298 249 KLWD 252
Cdd:cd00200  286 RIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
170-254 1.92e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 57.61  E-value: 1.92e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 183986298 170 DGHFASIDAVLLLQGGTLCLSGSRDRNVNLWDLRhlGKEPSRVLvkalgtqgnSTHKGWVWSLA--AQDHRVCSGSWDST 247
Cdd:COG2319  327 TGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA--TGELLRTL---------TGHTGAVTSVAfsPDGRTLASGSADGT 395


                 ....*..
gi 183986298 248 VKLWDMA 254
Cdd:COG2319  396 VRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
170-264 2.15e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 57.61  E-value: 2.15e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 183986298 170 DGHFASIDAVLLLQGGTLCLSGSRDRNVNLWDLRhlGKEPSRVLvkalgtqgnSTHKGWVWSLA--AQDHRVCSGSWDST 247
Cdd:COG2319  243 TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA--TGELLRTL---------TGHSGGVNSVAfsPDGKLLASGSDDGT 311

                         90
                 ....*....|....*..
gi 183986298 248 VKLWDmAADGQQFGEIK 264
Cdd:COG2319  312 VRLWD-LATGKLLRTLT 327
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 171-256 2.83e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.57  E-value: 2.83e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 183986298 171 GHFASIDAVLLLQGGTLCLSGSRDRNVNLWDLRhlGKEPSRVLvkalgtqgnSTHKGWVWSLAAQD--HRVCSGSWDSTV 248
Cdd:cd00200  133 GHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLR--TGKCVATL---------TGHTGEVNSVAFSPdgEKLLSSSSDGTI 201


                 ....*...
gi 183986298 249 KLWDMAAD 256
Cdd:cd00200  202 KLWDLSTG 209
WD40 COG2319
WD40 repeat [General function prediction only];
170-254 1.07e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.30  E-value: 1.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 183986298 170 DGHFASIDAVLLLQGGTLCLSGSRDRNVNLWDLRhlgkepSRVLVKALgtqgnSTHKGWVWSLA--AQDHRVCSGSWDST 247
Cdd:COG2319  285 TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA------TGKLLRTL-----TGHTGAVRSVAfsPDGKTLASGSDDGT 353


                 ....*..
gi 183986298 248 VKLWDMA 254
Cdd:COG2319  354 VRLWDLA 360
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 170-252 7.83e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 52.34  E-value: 7.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 183986298 170 DGHFASIDAVLLLQGGTLCLSGSRDRNVNLWDLRhlGKEPSRVLVkalgtqgnsTHKGWVWSLA--AQDHRVCSGSWDST 247
Cdd:cd00200    6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE--TGELLRTLK---------GHTGPVRDVAasADGTYLASGSSDKT 74


                 ....*
gi 183986298 248 VKLWD 252
Cdd:cd00200   75 IRLWD 79
WD40 COG2319
WD40 repeat [General function prediction only];
170-259 8.27e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.61  E-value: 8.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 183986298 170 DGHFASIDAVLLLQGGTLCLSGSRDRNVNLWDLRhlGKEPSRVLvkalgtqgnSTHKGWVWSLA--AQDHRVCSGSWDST 247
Cdd:COG2319  201 TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA--TGKLLRTL---------TGHSGSVRSVAfsPDGRLLASGSADGT 269

                         90
                 ....*....|..
gi 183986298 248 VKLWDmAADGQQ 259
Cdd:COG2319  270 VRLWD-LATGEL 280
WD40 COG2319
WD40 repeat [General function prediction only];
171-254 1.51e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.84  E-value: 1.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 183986298 171 GHFASIDAVLLLQGGTLCLSGSRDRNVNLWDLRhlGKEPSRVLvkalgtqgnSTHKGWVWSLA--AQDHRVCSGSWDSTV 248
Cdd:COG2319  160 GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA--TGKLLRTL---------TGHTGAVRSVAfsPDGKLLASGSADGTV 228


                 ....*.
gi 183986298 249 KLWDMA 254
Cdd:COG2319  229 RLWDLA 234
WD40 COG2319
WD40 repeat [General function prediction only];
171-264 2.27e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.45  E-value: 2.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 183986298 171 GHFASIDAVLLLQGGTLCLSGSRDRNVNLWDLRhlGKEPSRVLvkalgtqgnSTHKGWVWSLA--AQDHRVCSGSWDSTV 248
Cdd:COG2319  118 GHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA--TGKLLRTL---------TGHSGAVTSVAfsPDGKLLASGSDDGTV 186

                         90
                 ....*....|....*.
gi 183986298 249 KLWDmAADGQQFGEIK 264
Cdd:COG2319  187 RLWD-LATGKLLRTLT 201
WD40 COG2319
WD40 repeat [General function prediction only];
113-264 2.56e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.07  E-value: 2.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 183986298 113 LVRDRVTWRLRAQRRVRSPYPVVEEENFDWPAACIELEQHLARWAEDGQRTEYfcLADGHFASIDAVLLLQGGTLCLSGS 192
Cdd:COG2319   20 LLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLA--TLLGHTAAVLSVAFSPDGRLLASAS 97

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 183986298 193 RDRNVNLWDLRhlGKEPSRVLVKalgtqgnstHKGWVWSLA--AQDHRVCSGSWDSTVKLWDmAADGQQFGEIK 264
Cdd:COG2319   98 ADGTVRLWDLA--TGLLLRTLTG---------HTGAVRSVAfsPDGKTLASGSADGTVRLWD-LATGKLLRTLT 159
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 171-253 1.36e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.49  E-value: 1.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 183986298 171 GHFASIDAVLLLQGGTLCLSGSRDRNVNLWDLRhlGKEPSRVLVKalgtqgnstHKGWVWSLAAQDHR--VCSGSWDSTV 248
Cdd:cd00200  175 GHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS--TGKCLGTLRG---------HENGVNSVAFSPDGylLASGSEDGTI 243


                 ....*
gi 183986298 249 KLWDM 253
Cdd:cd00200  244 RVWDL 248
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 225-252 1.10e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.10e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 183986298   225 HKGWVWSLA--AQDHRVCSGSWDSTVKLWD 252
Cdd:smart00320  11 HTGPVTSVAfsPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
225-252 2.08e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 2.08e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 183986298  225 HKGWVWSLA--AQDHRVCSGSWDSTVKLWD 252
Cdd:pfam00400  10 HTGSVTSLAfsPDGKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 225-254 2.58e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 38.47  E-value: 2.58e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 183986298 225 HKGWVWSLAAQDH--RVCSGSWDSTVKLWDMA 254
Cdd:cd00200    8 HTGGVTCVAFSPDgkLLATGSGDGTIKVWDLE 39
WD40 pfam00400
WD domain, G-beta repeat;
170-201 3.73e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 3.73e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 183986298  170 DGHFASIDAVLLLQGGTLCLSGSRDRNVNLWD 201
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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