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Conserved domains on  [gi|190336779|gb|AAI62558|]
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Anxa2b protein [Danio rerio]

Protein Classification

annexin( domain architecture ID 10446041)

annexin belongs to a family of calcium- and phospholipid-binding proteins that have been implicated in many cellular processes, including channel formation, membrane fusion, vesicle transport, and regulation of phospholipase A2 activity

CATH:  1.10.220.10
Gene Ontology:  GO:0005509|GO:0005544|GO:0048306|GO:0003723
PubMed:  15059252|1646719
SCOP:  4001063
TCDB:  1.A.31

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 108-173 2.22e-24

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 94.08  E-value: 2.22e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 190336779  108 YDAFELKASMKGLGTDEESLIEMVCSRNKEELAEIKKVYKEMFKKDLEKDISGDTSGDFAKLLLAL 173
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 268-333 9.11e-17

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 73.66  E-value: 9.11e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 190336779  268 YFASRLNDAMKGKSVKDKIITRIIVSRCEVDLMKVRIEFKRNFGRSLHQTISEHTKGDYQRALLNL 333
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 37-101 1.97e-16

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 72.51  E-value: 1.97e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 190336779   37 DAAKIETAIKTKGVDEQTIIDILTRRSYLQRSDIAFEYEKRAKKDLVSALKGALSGSLEHLILGL 101
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 193-258 1.39e-12

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 62.11  E-value: 1.39e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 190336779  193 DARTLYEtGVRRKGTDVVTWISIFSERSVSHLQKVFERYKRYSPYDIKESIRMEVKGDLEKSFLTL 258
Cdd:pfam00191   2 DAELLRK-AMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 108-173 2.22e-24

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 94.08  E-value: 2.22e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 190336779  108 YDAFELKASMKGLGTDEESLIEMVCSRNKEELAEIKKVYKEMFKKDLEKDISGDTSGDFAKLLLAL 173
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
121-173 6.67e-19

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 78.99  E-value: 6.67e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 190336779   121 GTDEESLIEMVCSRNKEELAEIKKVYKEMFKKDLEKDISGDTSGDFAKLLLAL 173
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 268-333 9.11e-17

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 73.66  E-value: 9.11e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 190336779  268 YFASRLNDAMKGKSVKDKIITRIIVSRCEVDLMKVRIEFKRNFGRSLHQTISEHTKGDYQRALLNL 333
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 37-101 1.97e-16

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 72.51  E-value: 1.97e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 190336779   37 DAAKIETAIKTKGVDEQTIIDILTRRSYLQRSDIAFEYEKRAKKDLVSALKGALSGSLEHLILGL 101
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
49-101 4.35e-13

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 62.81  E-value: 4.35e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 190336779    49 GVDEQTIIDILTRRSYLQRSDIAFEYEKRAKKDLVSALKGALSGSLEHLILGL 101
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 193-258 1.39e-12

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 62.11  E-value: 1.39e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 190336779  193 DARTLYEtGVRRKGTDVVTWISIFSERSVSHLQKVFERYKRYSPYDIKESIRMEVKGDLEKSFLTL 258
Cdd:pfam00191   2 DAELLRK-AMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
284-333 3.47e-12

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 60.50  E-value: 3.47e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 190336779   284 DKIITRIIVSRCEVDLMKVRIEFKRNFGRSLHQTISEHTKGDYQRALLNL 333
Cdd:smart00335   4 EKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
206-258 5.02e-09

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 51.64  E-value: 5.02e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 190336779   206 GTDVVTWISIFSERSVSHLQKVFERYKRYSPYDIKESIRMEVKGDLEKSFLTL 258
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 108-173 2.22e-24

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 94.08  E-value: 2.22e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 190336779  108 YDAFELKASMKGLGTDEESLIEMVCSRNKEELAEIKKVYKEMFKKDLEKDISGDTSGDFAKLLLAL 173
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
121-173 6.67e-19

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 78.99  E-value: 6.67e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 190336779   121 GTDEESLIEMVCSRNKEELAEIKKVYKEMFKKDLEKDISGDTSGDFAKLLLAL 173
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 268-333 9.11e-17

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 73.66  E-value: 9.11e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 190336779  268 YFASRLNDAMKGKSVKDKIITRIIVSRCEVDLMKVRIEFKRNFGRSLHQTISEHTKGDYQRALLNL 333
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 37-101 1.97e-16

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 72.51  E-value: 1.97e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 190336779   37 DAAKIETAIKTKGVDEQTIIDILTRRSYLQRSDIAFEYEKRAKKDLVSALKGALSGSLEHLILGL 101
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
49-101 4.35e-13

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 62.81  E-value: 4.35e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 190336779    49 GVDEQTIIDILTRRSYLQRSDIAFEYEKRAKKDLVSALKGALSGSLEHLILGL 101
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 193-258 1.39e-12

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 62.11  E-value: 1.39e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 190336779  193 DARTLYEtGVRRKGTDVVTWISIFSERSVSHLQKVFERYKRYSPYDIKESIRMEVKGDLEKSFLTL 258
Cdd:pfam00191   2 DAELLRK-AMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
284-333 3.47e-12

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 60.50  E-value: 3.47e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 190336779   284 DKIITRIIVSRCEVDLMKVRIEFKRNFGRSLHQTISEHTKGDYQRALLNL 333
Cdd:smart00335   4 EKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
206-258 5.02e-09

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 51.64  E-value: 5.02e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 190336779   206 GTDVVTWISIFSERSVSHLQKVFERYKRYSPYDIKESIRMEVKGDLEKSFLTL 258
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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