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Conserved domains on  [gi|157423397|gb|AAI53311|]
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Zgc:171626 protein [Danio rerio]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
16-437 1.41e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.63  E-value: 1.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157423397  16 TFTVKQEDLQEQKDLMVLKEETHQQNEMEEKLQ--EITTDEKPTL-NKKTSSRGRPRKSKSACNFSSKqsRKSFSQKSNL 92
Cdd:COG5048    2 TLTSSQSSSSNNSVLSSTPKSTLKSLSNAPRPDscPNCTDSFSRLeHLTRHIRSHTGEKPSQCSYSGC--DKSFSRPLEL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157423397  93 DVHMRVHTREKPYTCEQCGKSFGHIQGF-ENHMRIHTGEKPFSCKQCGKSFSQKANLDVHMRVHTKERPYTCEQCGKSFT 171
Cdd:COG5048   80 SRHLRTHHNNPSDLNSKSLPLSNSKASSsSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157423397 172 -YKQGFTTHMRIHTGERPytcqqceKSFYHPGNFAVHMRIHTGERPYICQQCGKSFYQSGNFAAHMRIHTGERPYSCIQC 250
Cdd:COG5048  160 nTPQSNSLHPPLPANSLS-------KDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157423397 251 GKSFKQNGTLEVHMRT------HTGDRSFICTHCGKHFSQKHDLNIHMRIHTG-EKPHTCTQCGKRFTQKTICDNHMR-- 321
Cdd:COG5048  233 SQLSPKSLLSQSPSSLsssdssSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsv 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157423397 322 IHTGE--KPYRCTE--CGKTFPHKSTLKHHMRTHTGEKPFAC--TQCGKRFT---TKASLKNLMDNHTGTIVLTCDQ--- 389
Cdd:COG5048  313 NHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSpllNNEPPQSLQQYKDLKNDKKSETlsn 392

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 157423397 390 -CEKSLTRKDSIRKH-IRKINSGEDPFRCSECGKGFKHKRSLNTHLKLHI 437
Cdd:COG5048  393 sCIRNFKRDSNLSLHiITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHT 442
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
16-437 1.41e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.63  E-value: 1.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157423397  16 TFTVKQEDLQEQKDLMVLKEETHQQNEMEEKLQ--EITTDEKPTL-NKKTSSRGRPRKSKSACNFSSKqsRKSFSQKSNL 92
Cdd:COG5048    2 TLTSSQSSSSNNSVLSSTPKSTLKSLSNAPRPDscPNCTDSFSRLeHLTRHIRSHTGEKPSQCSYSGC--DKSFSRPLEL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157423397  93 DVHMRVHTREKPYTCEQCGKSFGHIQGF-ENHMRIHTGEKPFSCKQCGKSFSQKANLDVHMRVHTKERPYTCEQCGKSFT 171
Cdd:COG5048   80 SRHLRTHHNNPSDLNSKSLPLSNSKASSsSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157423397 172 -YKQGFTTHMRIHTGERPytcqqceKSFYHPGNFAVHMRIHTGERPYICQQCGKSFYQSGNFAAHMRIHTGERPYSCIQC 250
Cdd:COG5048  160 nTPQSNSLHPPLPANSLS-------KDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157423397 251 GKSFKQNGTLEVHMRT------HTGDRSFICTHCGKHFSQKHDLNIHMRIHTG-EKPHTCTQCGKRFTQKTICDNHMR-- 321
Cdd:COG5048  233 SQLSPKSLLSQSPSSLsssdssSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsv 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157423397 322 IHTGE--KPYRCTE--CGKTFPHKSTLKHHMRTHTGEKPFAC--TQCGKRFT---TKASLKNLMDNHTGTIVLTCDQ--- 389
Cdd:COG5048  313 NHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSpllNNEPPQSLQQYKDLKNDKKSETlsn 392

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 157423397 390 -CEKSLTRKDSIRKH-IRKINSGEDPFRCSECGKGFKHKRSLNTHLKLHI 437
Cdd:COG5048  393 sCIRNFKRDSNLSLHiITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
287-312 5.58e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 5.58e-04
                          10        20
                  ....*....|....*....|....*.
gi 157423397  287 DLNIHMRIHTGEKPHTCTQCGKRFTQ 312
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
16-437 1.41e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.63  E-value: 1.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157423397  16 TFTVKQEDLQEQKDLMVLKEETHQQNEMEEKLQ--EITTDEKPTL-NKKTSSRGRPRKSKSACNFSSKqsRKSFSQKSNL 92
Cdd:COG5048    2 TLTSSQSSSSNNSVLSSTPKSTLKSLSNAPRPDscPNCTDSFSRLeHLTRHIRSHTGEKPSQCSYSGC--DKSFSRPLEL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157423397  93 DVHMRVHTREKPYTCEQCGKSFGHIQGF-ENHMRIHTGEKPFSCKQCGKSFSQKANLDVHMRVHTKERPYTCEQCGKSFT 171
Cdd:COG5048   80 SRHLRTHHNNPSDLNSKSLPLSNSKASSsSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157423397 172 -YKQGFTTHMRIHTGERPytcqqceKSFYHPGNFAVHMRIHTGERPYICQQCGKSFYQSGNFAAHMRIHTGERPYSCIQC 250
Cdd:COG5048  160 nTPQSNSLHPPLPANSLS-------KDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157423397 251 GKSFKQNGTLEVHMRT------HTGDRSFICTHCGKHFSQKHDLNIHMRIHTG-EKPHTCTQCGKRFTQKTICDNHMR-- 321
Cdd:COG5048  233 SQLSPKSLLSQSPSSLsssdssSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsv 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157423397 322 IHTGE--KPYRCTE--CGKTFPHKSTLKHHMRTHTGEKPFAC--TQCGKRFT---TKASLKNLMDNHTGTIVLTCDQ--- 389
Cdd:COG5048  313 NHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSpllNNEPPQSLQQYKDLKNDKKSETlsn 392

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 157423397 390 -CEKSLTRKDSIRKH-IRKINSGEDPFRCSECGKGFKHKRSLNTHLKLHI 437
Cdd:COG5048  393 sCIRNFKRDSNLSLHiITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
70-364 1.64e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.16  E-value: 1.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157423397  70 KSKSACNFSSKQSRKSFSQKSNLDVHMRVHTREKPYTCEQCG-KSFGHIQGFENHMRIHTGEKPFSCKQCgKSFSQKANL 148
Cdd:COG5048  149 NPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSnVSTSIPSSSENSPLSSSYSIPSSSSDQ-NLENSSSSL 227

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157423397 149 DVHMRVHTKERPYTCEQcgksftYKQGFTTHMRIHTGERPYTCQQcEKSFYHPGNFAVHMRIHTGER-PYICQQCGKSFY 227
Cdd:COG5048  228 PLTTNSQLSPKSLLSQS------PSSLSSSDSSSSASESPRSSLP-TASSQSSSPNESDSSSEKGFSlPIKSKQCNISFS 300

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157423397 228 QSGNFAAHMR--IHTGE--RPYSC--IQCGKSFKQNGTLEVHMRTHTGDRSFIC--THCGKHFSQK-----HDLNIHMRI 294
Cdd:COG5048  301 RSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLlnnepPQSLQQYKD 380

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157423397 295 HTGEKPHTCTQCGKRFTQKT----ICDNHMRIHTGEKPYRCTECGKTFPHKSTLKHHMRTHTGEKPFACTQCGK 364
Cdd:COG5048  381 LKNDKKSETLSNSCIRNFKRdsnlSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
157-438 3.03e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 3.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157423397 157 KERPYTCEQCGKSFTYKQGFTTHMRIHTGERPYTC--QQCEKSFYHPGNFAVHMRIHTGERPYIC-QQCGKSFYQSGNFA 233
Cdd:COG5048   30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157423397 234 AHMRIHTGERPYSCIQCGKSFKQNGTLEVHMRTHT---------GDRSFICT-------------HCGKHFSQKHDLNIH 291
Cdd:COG5048  110 LSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISnlrnnplpgNNSSSVNTpqsnslhpplpanSLSKDPSSNLSLLIS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157423397 292 MRIHTGEKPHTCTQCGKRFTQKTICDNHMRIHTGEKPYRCTECGKTFPHKSTLKHHMRTHTGEKPFACTQCGKRFTTKAS 371
Cdd:COG5048  190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTAS 269

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157423397 372 LKNLMDNHTG-------TIVLTCDQCEKSLTRKDSIRKHIRKIN-SGED--PFRCSE--CGKGFKHKRSLNTHLKLHIG 438
Cdd:COG5048  270 SQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRSVNhSGESlkPFSCPYslCGKLFSRNDALKRHILLHTS 348
zf-H2C2_2 pfam13465
Zinc-finger double domain;
287-312 5.58e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 5.58e-04
                          10        20
                  ....*....|....*....|....*.
gi 157423397  287 DLNIHMRIHTGEKPHTCTQCGKRFTQ 312
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
120-144 7.56e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 7.56e-04
                          10        20
                  ....*....|....*....|....*
gi 157423397  120 FENHMRIHTGEKPFSCKQCGKSFSQ 144
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
147-172 8.76e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 8.76e-04
                          10        20
                  ....*....|....*....|....*.
gi 157423397  147 NLDVHMRVHTKERPYTCEQCGKSFTY 172
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
231-256 1.20e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.20e-03
                          10        20
                  ....*....|....*....|....*.
gi 157423397  231 NFAAHMRIHTGERPYSCIQCGKSFKQ 256
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 329-351 1.35e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.35e-03
                          10        20
                  ....*....|....*....|...
gi 157423397  329 YRCTECGKTFPHKSTLKHHMRTH 351
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
347-368 1.38e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.38e-03
                          10        20
                  ....*....|....*....|..
gi 157423397  347 HMRTHTGEKPFACTQCGKRFTT 368
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
319-338 2.12e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.12e-03
                          10        20
                  ....*....|....*....|
gi 157423397  319 HMRIHTGEKPYRCTECGKTF 338
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
91-114 2.34e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.34e-03
                          10        20
                  ....*....|....*....|....
gi 157423397   91 NLDVHMRVHTREKPYTCEQCGKSF 114
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
179-200 6.82e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 6.82e-03
                          10        20
                  ....*....|....*....|..
gi 157423397  179 HMRIHTGERPYTCQQCEKSFYH 200
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 273-295 8.35e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 8.35e-03
                          10        20
                  ....*....|....*....|...
gi 157423397  273 FICTHCGKHFSQKHDLNIHMRIH 295
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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