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Conserved domains on  [gi|148877497|gb|AAI45657|]
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Homeo box D12 [Mus musculus]

Protein Classification

homeobox domain-containing protein( domain architecture ID 10441114)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes

CATH:  1.10.10.60
Gene Ontology:  GO:0003677
PubMed:  21557080|26464018|27768937|1357790
SCOP:  4000291

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
201-257 4.96e-25

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 94.10  E-value: 4.96e-25
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 148877497  201 RKKRKPYTKQQIAELENEFLVNEFINRQKRKELSNRLNLSDQQVKIWFQNRRMKKKR 257
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 37-123 7.67e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 37.61  E-value: 7.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148877497   37 AALPPISYPRSALPwatTPASCTPAQPATASafgGFSQPYLTGSGPIGLQSPGAKDGPEDQVKfYTPDAPTASEERSRTR 116
Cdd:PHA03247 2816 AALPPAASPAGPLP---PPTSAQPTAPPPPP---GPPPPSLPLGGSVAPGGDVRRRPPSRSPA-AKPAAPARPPVRRLAR 2888


                  ....*..
gi 148877497  117 PPFAPES 123
Cdd:PHA03247 2889 PAVSRST 2895
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
201-257 4.96e-25

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 94.10  E-value: 4.96e-25
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 148877497  201 RKKRKPYTKQQIAELENEFLVNEFINRQKRKELSNRLNLSDQQVKIWFQNRRMKKKR 257
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 201-257 6.55e-22

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 86.14  E-value: 6.55e-22
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 148877497 201 RKKRKPYTKQQIAELENEFLVNEFINRQKRKELSNRLNLSDQQVKIWFQNRRMKKKR 257
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 201-256 3.54e-21

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 83.84  E-value: 3.54e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 148877497   201 RKKRKPYTKQQIAELENEFLVNEFINRQKRKELSNRLNLSDQQVKIWFQNRRMKKK 256
Cdd:smart00389   2 RRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
194-257 1.00e-11

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 61.68  E-value: 1.00e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 148877497 194 GAAPGRARKKRKpyTKQQIAELENEFLVNEFINRQKRKELSNRLNLSDQQVKIWFQNRRMKKKR 257
Cdd:COG5576   47 GSSPPKSKRRRT--TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKK 108
PHA03247 PHA03247
large tegument protein UL36; Provisional
 37-123 7.67e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 37.61  E-value: 7.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148877497   37 AALPPISYPRSALPwatTPASCTPAQPATASafgGFSQPYLTGSGPIGLQSPGAKDGPEDQVKfYTPDAPTASEERSRTR 116
Cdd:PHA03247 2816 AALPPAASPAGPLP---PPTSAQPTAPPPPP---GPPPPSLPLGGSVAPGGDVRRRPPSRSPA-AKPAAPARPPVRRLAR 2888


                  ....*..
gi 148877497  117 PPFAPES 123
Cdd:PHA03247 2889 PAVSRST 2895
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
201-257 4.96e-25

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 94.10  E-value: 4.96e-25
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 148877497  201 RKKRKPYTKQQIAELENEFLVNEFINRQKRKELSNRLNLSDQQVKIWFQNRRMKKKR 257
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 201-257 6.55e-22

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 86.14  E-value: 6.55e-22
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 148877497 201 RKKRKPYTKQQIAELENEFLVNEFINRQKRKELSNRLNLSDQQVKIWFQNRRMKKKR 257
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 201-256 3.54e-21

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 83.84  E-value: 3.54e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 148877497   201 RKKRKPYTKQQIAELENEFLVNEFINRQKRKELSNRLNLSDQQVKIWFQNRRMKKK 256
Cdd:smart00389   2 RRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
194-257 1.00e-11

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 61.68  E-value: 1.00e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 148877497 194 GAAPGRARKKRKpyTKQQIAELENEFLVNEFINRQKRKELSNRLNLSDQQVKIWFQNRRMKKKR 257
Cdd:COG5576   47 GSSPPKSKRRRT--TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKK 108
PHA03247 PHA03247
large tegument protein UL36; Provisional
 37-123 7.67e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 37.61  E-value: 7.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148877497   37 AALPPISYPRSALPwatTPASCTPAQPATASafgGFSQPYLTGSGPIGLQSPGAKDGPEDQVKfYTPDAPTASEERSRTR 116
Cdd:PHA03247 2816 AALPPAASPAGPLP---PPTSAQPTAPPPPP---GPPPPSLPLGGSVAPGGDVRRRPPSRSPA-AKPAAPARPPVRRLAR 2888


                  ....*..
gi 148877497  117 PPFAPES 123
Cdd:PHA03247 2889 PAVSRST 2895
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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