ATP-binding cassette domain of Rad50; The catalytic domains of Rad50 are similar to the ATP-binding cassette of ABC transporters, but are not associated with membrane-spanning domains. The conserved ATP-binding motifs common to Rad50 and the ABC transporter family include the Walker A and Walker B motifs, the Q loop, a histidine residue in the switch region, a D-loop, and a conserved LSGG sequence. This conserved sequence, LSGG, is the most specific and characteristic motif of this family and is thus known as the ABC signature sequence.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146327056   4 IEKMSILGVRSFgiedKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNtfVHDPKVAQETDVRAQIR 83
Cdd:cd03240    1 IDKLSIRNIRSF----HERSEIEFFSPLTLIVGQNGAGKTTIIEALKYALTGELPPNSKGG--AHDPKLIREGEVRAQVK 74

                         90
                 ....*....|....*..
gi 146327056  84 LQFRDVNGELIAVQRSM 100
Cdd:cd03240   75 LAFENANGKKYTITRSL 91

DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146327056   3 RIEKMSILGVRSFgiedKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTK-GNTFVHDPkvaqetDVRAQ 81
Cdd:COG0419    1 KLLRLRLENFRSY----RDTETIDFDDGLNLIVGPNGAGKSTILEAIRYALYGKARSRSKlRSDLINVG------SEEAS 70

                         90
                 ....*....|....*..
gi 146327056  82 IRLQFrDVNGELIAVQR 98
Cdd:COG0419   71 VELEF-EHGGKRYRIER 86

PrkA AAA domain; This is a family of PrkA bacterial and archaeal serine kinases approximately 630 residues long. This is the N-terminal AAA domain.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 146327056    15 FGIEDKDKQIITFFSP----------LTILVGPNGAGKTTIIECLK 50
Cdd:smart00763  54 FGMEEAIERFVNYFKSaaqgleerkqILYLLGPVGGGKSSLVECLK 99

ATP-binding cassette domain of Rad50; The catalytic domains of Rad50 are similar to the ATP-binding cassette of ABC transporters, but are not associated with membrane-spanning domains. The conserved ATP-binding motifs common to Rad50 and the ABC transporter family include the Walker A and Walker B motifs, the Q loop, a histidine residue in the switch region, a D-loop, and a conserved LSGG sequence. This conserved sequence, LSGG, is the most specific and characteristic motif of this family and is thus known as the ABC signature sequence.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146327056   4 IEKMSILGVRSFgiedKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNtfVHDPKVAQETDVRAQIR 83
Cdd:cd03240    1 IDKLSIRNIRSF----HERSEIEFFSPLTLIVGQNGAGKTTIIEALKYALTGELPPNSKGG--AHDPKLIREGEVRAQVK 74

                         90
                 ....*....|....*..
gi 146327056  84 LQFRDVNGELIAVQRSM 100
Cdd:cd03240   75 LAFENANGKKYTITRSL 91

ATP-binding cassette domain of non-transporter proteins; ABC-type Class 2 contains systems involved in cellular processes other than transport. These families are characterized by the fact that the ABC subunit is made up of duplicated, fused ABC modules (ABC2). No known transmembrane proteins or domains are associated with these proteins.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146327056   6 KMSILGVRSFGIEdkdkQIITFFSP-LTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKVAQETDVRAQIRL 84
Cdd:cd03227    1 KIVLGRFPSYFVP----NDVTFGEGsLTIITGPNGSGKSTILDAIGLALGGAQSATRRRSGVKAGCIVAAVSAELIFTRL 76

                 .
gi 146327056  85 Q 85
Cdd:cd03227   77 Q 77

Predicted ATP-dependent endonuclease of the OLD family, contains P-loop ATPase and TOPRIM domains [Replication, recombination and repair];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146327056   3 RIEKMSILGVRSFGiedkdKQIITFFSPLTILVGPNGAGKTTIIECLKYIctgdFPPGTKGNTFVHD-PKVAQETDVRAQ 81
Cdd:COG3593    2 KLEKIKIKNFRSIK-----DLSIELSDDLTVLVGENNSGKSSILEALRLL----LGPSSSRKFDEEDfYLGDDPDLPEIE 72

                         90
                 ....*....|...
gi 146327056  82 IRLQFRDVNGELI 94
Cdd:COG3593   73 IELTFGSLLSRLL 85

Wobble nucleotide-excising tRNase [Translation, ribosomal structure and biogenesis];

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 146327056   1 MSRIEKMSilGVRSFgiedKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGD 56
Cdd:COG4694    2 ITKIKKLK--NVGAF----KDFGWLAFFKKLNLIYGENGSGKSTLSRILRSLELGD 51

Predicted ATPase [General function prediction only];

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 146327056  25 ITFFSPLTILVGPNGAGKTTIIECLKYICtgDFPP--GTKGNTFVHDP 70
Cdd:COG3910   33 LEFHPPVTFFVGENGSGKSTLLEAIAVAA--GFNPegGSKNFRFSTRE 78

ATP-binding cassette domain of the lipid transporters, subfamily A; The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency, degenerative retinopathies, and congenital keratinization disorders. The ABCA1 protein is involved in disorders of cholesterol transport and high-density lipoprotein (HDL) biosynthesis. The ABCA4 (ABCR) protein transports vitamin A derivatives in the outer segments of photoreceptor cells, and therefore, performs a crucial step in the visual cycle. The ABCA genes are not present in yeast. However, evolutionary studies of ABCA genes indicate that they arose as transporters that subsequently duplicated and that certain sets of ABCA genes were lost in different eukaryotic lineages.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 146327056  34 LVGPNGAGKTTIIECLkyicTGDFPPgTKGNTFVHDpkvaqetdvraqirlqfRDVNGELIAVQRSM-VCTQK 105
Cdd:cd03263   33 LLGHNGAGKTTTLKML----TGELRP-TSGTAYING-----------------YSIRTDRKAARQSLgYCPQF 83

AAA domain, putative AbiEii toxin, Type IV TA system; Several members are annotated as being of the abortive phage resistance system, in which case the family would be acting as the toxin for a type IV toxin-antitoxin resistance system.

                          10        20
                  ....*....|....*....|...
gi 146327056   31 LTILVGPNGAGKTTIIECLKYIC 53
Cdd:pfam13304   1 INVLIGPNGSGKSNLLEALRFLA 23

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 146327056     4 IEKMSILGVRSFGiedkDKQIITFFSPLTILVGPNGAGKTTIIECL 49
Cdd:TIGR02169    2 IERIELENFKSFG----KKKVIPFSKGFTVISGPNGSGKSNIGDAI 43

ABC-type branched-chain amino acid transport system, ATPase component LivG [Amino acid transport and metabolism];

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 146327056  34 LVGPNGAGKTTIIECLkyicTGDFPPgTKGntfvhdpkvaqetdvraQIRLQFRDVNG 91
Cdd:COG0411   35 LIGPNGAGKTTLFNLI----TGFYRP-TSG-----------------RILFDGRDITG 70

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 146327056     3 RIEKMSILGVRSFGiedkDKQIITFFSPLTILVGPNGAGKTTIIECLK 50
Cdd:TIGR02168    1 RLKKLELAGFKSFA----DPTTINFDKGITGIVGPNGCGKSNIVDAIR 44

Daunorubicin/doxorubicin resistance ATP-binding protein; DrrA is the ATP-binding protein component of a bacterial exporter complex that confers resistance to the antibiotics daunorubicin and doxorubicin. In addition to DrrA, the complex includes an integral membrane protein called DrrB. DrrA belongs to the ABC family of transporters and shares sequence and functional similarities with a protein found in cancer cells called P-glycoprotein. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region in addition to the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 146327056  34 LVGPNGAGKTTIIECLkyiCTGDFPPGTKGNTFVHDpKVAQETDVRAQIRLQFRD--VNGELIAVQ 97
Cdd:cd03265   31 LLGPNGAGKTTTIKML---TTLLKPTSGRATVAGHD-VVREPREVRRRIGIVFQDlsVDDELTGWE 92

hemin importer ATP-binding subunit; Provisional

                         10        20        30
                 ....*....|....*....|....*....|.
gi 146327056  31 LTILVGPNGAGKTTIIECLkyicTGDFPPGT 61
Cdd:PRK13548  30 VVAILGPNGAGKSTLLRAL----SGELSPDS 56

ATP-binding cassette domain of RecF; RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication fork, allowing it to resume and complete its task. This CD represents the nucleotide binding domain of RecF. RecF belongs to a large superfamily of ABC transporters involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases with a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 146327056  25 ITFFSPLTILVGPNGAGKTTIIECLKYICTGdfppgtKGNTFVHDPKVAQETDVRAQIR 83
Cdd:cd03242   17 LEFEPGVTVLVGENAQGKTNLLEAISLLATG------KSHRTSRDKELIRWGAEEAKIS 69

ATPase/GTPase, AAA15 family [General function prediction only];

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 146327056  13 RSFgiedKDKQIITF------FSPLTILVGPNGAGKTTIIECLKYIC 53
Cdd:COG1106   11 RSF----KDELTLSMvasglrLLRVNLIYGANASGKSNLLEALYFLR 53

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146327056     3 RIEKMSILGVRSFgiedKDKQIITF--FSPLTILVGPNGAGKTTIIECLKYICTGDFPpgTKGNTFVHDPKVAQETDVRA 80
Cdd:TIGR00618    2 KPLRLTLKNFGSY----KGTHTIDFtaLGPIFLICGKTGAGKTTLLDAITYALYGKLP--RRSEVIRSLNSLYAAPSEAA 75

                           90       100
                   ....*....|....*....|....*...
gi 146327056    81 QIRLQFrDVNGELIAVQRSMVCTQKSKK 108
Cdd:TIGR00618   76 FAELEF-SLGTKIYRVHRTLRCTRSHRK 102

leucine/isoleucine/valine transporter ATP-binding subunit; Provisional

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 146327056   9 ILGVRSFGIEDKDKQIITffspltiLVGPNGAGKTTIIECL 49
Cdd:PRK11300  18 LLAVNNVNLEVREQEIVS-------LIGPNGAGKTTVFNCL 51

ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

                         10
                 ....*....|....*....
gi 146327056  31 LTILVGPNGAGKTTIIECL 49
Cdd:cd00267   27 IVALVGPNGSGKSTLLRAI 45

ABC-type cobalamin/Fe3+-siderophores transport system, ATPase component [Inorganic ion transport and metabolism, Coenzyme transport and metabolism];

                         10
                 ....*....|....*....
gi 146327056  31 LTILVGPNGAGKTTIIECL 49
Cdd:COG1120   29 VTALLGPNGSGKSTLLRAL 47

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 146327056    3 RIEKMSILGVRSFgiedkDKQIITFFSPLTILVGPNGAGKTTIIECL 49
Cdd:pfam13175   2 KIKSIIIKNFRCL-----KDTEIDLDEDLTVLIGKNNSGKSSILEAL 43

Predicted ABC-type ATPase or kinase [General function prediction only];

                         10
                 ....*....|....*..
gi 146327056  31 LTILVGPNGAGKTTIIE 47
Cdd:COG4185    6 LYIIAGPNGAGKSTFAR 22

ATP-binding cassette domain of the binding protein-dependent transport systems; This class is comprised of all BPD (Binding Protein Dependent) systems that are largely represented in archaea and eubacteria and are primarily involved in scavenging solutes from the environment. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 146327056  32 TILVGPNGAGKTTIIECLkyicTGDFPPgTKGNTFVHDPKVAQETDVRAQIR 83
Cdd:cd03229   29 VALLGPSGSGKSTLLRCI----AGLEEP-DSGSILIDGEDLTDLEDELPPLR 75

ABC-type uncharacterized transport system, ATPase component [General function prediction only];

                         10
                 ....*....|...
gi 146327056  34 LVGPNGAGKTTII 46
Cdd:COG4152   32 LLGPNGAGKTTTI 44

ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC transporter mediating vitamin B12 uptake. The two ATP-binding cassettes (BtuD) are in close contact with each other, as are the two membrane-spanning subunits (BtuC); this arrangement is distinct from that observed for the E. coli lipid flippase MsbA. The BtuC subunits provide 20 transmembrane helices grouped around a translocation pathway that is closed to the cytoplasm by a gate region, whereas the dimer arrangement of the BtuD subunits resembles the ATP-bound form of the Rad50 DNA repair enzyme. A prominent cytoplasmic loop of BtuC forms the contact region with the ATP-binding cassette and represent a conserved motif among the ABC transporters.

                         10
                 ....*....|....*....
gi 146327056  31 LTILVGPNGAGKTTIIECL 49
Cdd:cd03214   27 IVGILGPNGAGKSTLLKTL 45

ATP-binding cassette domain of the metal-type transporters; This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-siderophore uptake family suggesting that they share a common ancestor. The best characterized metal-type ABC transporters are the YfeABCD system of Y. pestis, the SitABCD system of Salmonella enterica serovar Typhimurium, and the SitABCD transporter of Shigella flexneri. Moreover other uncharacterized homologs of these metal-type transporters are mainly found in pathogens like Haemophilus or enteroinvasive E. coli isolates.

                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 146327056  31 LTILVGPNGAGKTTIIECLkyicTGDFPPgTKGNTFV 67
Cdd:cd03235   27 FLAIVGPNGAGKSTLLKAI----LGLLKP-TSGSIRV 58

Predicted Ser/Thr protein kinase [Signal transduction mechanisms];

                         10        20        30
                 ....*....|....*....|....*....|..
gi 146327056  19 DKDKQIItffspltILVGPNGAGKTTIIECLK 50
Cdd:COG2766  105 GERKRIL-------LLHGPVGSGKSTLARCLK 129

retinal-specific rim ABC transporter; This model describes the photoreceptor protein (rim protein) in eukaryotes. It is the member of ABC transporter superfamily. Rim protein is a membrane glycoprotein which is localized in the photoreceptor outer segment discs. Mutation/s in its genetic loci is implicated in the recessive Stargardt's disease. [Transport and binding proteins, Other]

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 146327056    21 DKQIITFF-SPLTILVGPNGAGKTTIIEclkyICTGDFPPgTKGNTFVHDPKVAQETDVRAQ 81
Cdd:TIGR01257  947 DRLNITFYeNQITAFLGHNGAGKTTTLS----ILTGLLPP-TSGTVLVGGKDIETNLDAVRQ 1003

ABC-type multidrug transport system, ATPase component; The biological function of this family is not well characterized, but display ABC domains similar to members of ABCA subfamily. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 146327056  34 LVGPNGAGKTTIIEclkyICTGDFPPgTKGNTFVHDPKV-AQETDVRAQI 82
Cdd:cd03264   30 LLGPNGAGKTTLMR----ILATLTPP-SSGTIRIDGQDVlKQPQKLRRRI 74

ABC transporter; ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain pfam00664. These four domains may belong to a single polypeptide or belong in different polypeptide chains.

                          10        20
                  ....*....|....*....|....*.
gi 146327056   34 LVGPNGAGKTTIIECLkyicTGDFPP 59
Cdd:pfam00005  16 LVGPNGAGKSTLLKLI----AGLLSP 37

ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];

                         10
                 ....*....|....*....
gi 146327056  31 LTILVGPNGAGKTTIIECL 49
Cdd:COG4988  365 RVALVGPSGAGKSTLLNLL 383

ATP-binding cassette domain of sbcCD; SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 146327056   3 RIEKMSILGVRSFgiedKDKQIITF----FSPLTILVGPNGAGKTTIIECLKY 51
Cdd:cd03279    2 KPLKLELKNFGPF----REEQVIDFtgldNNGLFLICGPTGAGKSTILDAITY 50

ATP-binding cassette domain of the bacitracin-resistance transporter; The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multi-enzyme complex BcrABC. Bacitracin has potent antibiotic activity against gram-positive bacteria. The inhibition of peptidoglycan biosynthesis is the best characterized bacterial effect of bacitracin. The bacitracin resistance of B. licheniformis is mediated by the ABC transporter Bcr which is composed of two identical BcrA ATP-binding subunits and one each of the integral membrane proteins, BcrB and BcrC. B. subtilis cells carrying bcr genes on high-copy number plasmids develop collateral detergent sensitivity, a similar phenomenon in human cells with overexpressed multi-drug resistance P-glycoprotein.

                         10
                 ....*....|....*.
gi 146327056  34 LVGPNGAGKTTIIECL 49
Cdd:cd03268   31 FLGPNGAGKTTTMKII 46

PrkA AAA domain; This is a family of PrkA bacterial and archaeal serine kinases approximately 630 residues long. This is the N-terminal AAA domain.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 146327056    15 FGIEDKDKQIITFFSP----------LTILVGPNGAGKTTIIECLK 50
Cdd:smart00763  54 FGMEEAIERFVNYFKSaaqgleerkqILYLLGPVGGGKSSLVECLK 99