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Conserved domains on  [gi|116497115|gb|AAI26163|]
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ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 [Homo sapiens]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 73-344 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467717  Cd Length: 272  Bit Score: 580.63  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115  73 TAARAFRKQMEDCCDPAHLFAMTKMNSPMGKSMWYDGEFLYSFTIDNSTYSLFPQATPFQLPLKKCAVVGNGGILKKSGC 152
Cdd:cd23989    1 TAVEAFRKLLEDCCDPKRLFAVTKHNSPLGKNLWFDGEFLHSHTVDNETYSLFPQDTPLQLPLKKCSVVGNGGILKNSGC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 153 GRQIDEANFVMRCNLPPLSSEYTKDVGSKSQLVTANPSIIRQRFQNLLWSRKTFVDNMKIYNHSYIYMPAFSMKTGTEPS 232
Cdd:cd23989   81 GQQIDRADFVMRCNLPPLSREYTDDVGTKTQLVTANPSIIDKRFQNLLWSRKSFVESMKVYGRSYIYMPAFSMKTGTDPS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 233 LRVYYTLSDVGANQTVLFANPNFLRSIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVAIYGFWPFSVNMHEQPISHHYY 312
Cdd:cd23989  161 LRVYYTLADVGANQTVLFANPNFLRNVGKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDERTISHHYY 240

                        250       260       270
                 ....*....|....*....|....*....|..
gi 116497115 313 DNVLPFSGFHAMPEEFLQLWYLHKIGALRMQL 344
Cdd:cd23989  241 DNVLPDSGFHAMPEEFLQLWHLHKSGVLRMQL 272
 
Name Accession Description Interval E-value
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 73-344 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 580.63  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115  73 TAARAFRKQMEDCCDPAHLFAMTKMNSPMGKSMWYDGEFLYSFTIDNSTYSLFPQATPFQLPLKKCAVVGNGGILKKSGC 152
Cdd:cd23989    1 TAVEAFRKLLEDCCDPKRLFAVTKHNSPLGKNLWFDGEFLHSHTVDNETYSLFPQDTPLQLPLKKCSVVGNGGILKNSGC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 153 GRQIDEANFVMRCNLPPLSSEYTKDVGSKSQLVTANPSIIRQRFQNLLWSRKTFVDNMKIYNHSYIYMPAFSMKTGTEPS 232
Cdd:cd23989   81 GQQIDRADFVMRCNLPPLSREYTDDVGTKTQLVTANPSIIDKRFQNLLWSRKSFVESMKVYGRSYIYMPAFSMKTGTDPS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 233 LRVYYTLSDVGANQTVLFANPNFLRSIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVAIYGFWPFSVNMHEQPISHHYY 312
Cdd:cd23989  161 LRVYYTLADVGANQTVLFANPNFLRNVGKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDERTISHHYY 240

                        250       260       270
                 ....*....|....*....|....*....|..
gi 116497115 313 DNVLPFSGFHAMPEEFLQLWYLHKIGALRMQL 344
Cdd:cd23989  241 DNVLPDSGFHAMPEEFLQLWHLHKSGVLRMQL 272
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 94-339 3.32e-103

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 304.14  E-value: 3.32e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115   94 MTKMNSPMGKSMWYdGEFLYSFTIDNSTYSLFPQATPFQ-LPLKKCAVVGNGGILKKSGCGRQIDEANFVMRCNLPPLsS 172
Cdd:pfam00777   2 LTKENFPLGEWIRY-SEWWLPFTVTEELLELLPKVSPFDnKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPT-K 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115  173 EYTKDVGSKSQLVTANP-SIIRQRFQNLLWS--RKTFVDNMKIYNH--SYIYMPAFSMKTGTEPSLRVYYTLSDVGANQT 247
Cdd:pfam00777  80 GYEKDVGSKTTLRTMNPeSAIDSKYGNLGFShpRDPFVEFVLVPFKgrDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPVD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115  248 ---VLFANPNFLRSIGKFW-KSRGIHAKRLSTGLFLVSAALGLCEEVAIYGFWPFsvnMHEQPISHHYYDNVLP----FS 319
Cdd:pfam00777 160 pdkVLFLHPDFLRYVANFWlRSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPF---LDSRGNSHHYYDNVLMkkggFY 236

                         250       260
                  ....*....|....*....|
gi 116497115  320 GFHAMPEEFLQLWYLHKIGA 339
Cdd:pfam00777 237 GVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 73-344 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 580.63  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115  73 TAARAFRKQMEDCCDPAHLFAMTKMNSPMGKSMWYDGEFLYSFTIDNSTYSLFPQATPFQLPLKKCAVVGNGGILKKSGC 152
Cdd:cd23989    1 TAVEAFRKLLEDCCDPKRLFAVTKHNSPLGKNLWFDGEFLHSHTVDNETYSLFPQDTPLQLPLKKCSVVGNGGILKNSGC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 153 GRQIDEANFVMRCNLPPLSSEYTKDVGSKSQLVTANPSIIRQRFQNLLWSRKTFVDNMKIYNHSYIYMPAFSMKTGTEPS 232
Cdd:cd23989   81 GQQIDRADFVMRCNLPPLSREYTDDVGTKTQLVTANPSIIDKRFQNLLWSRKSFVESMKVYGRSYIYMPAFSMKTGTDPS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 233 LRVYYTLSDVGANQTVLFANPNFLRSIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVAIYGFWPFSVNMHEQPISHHYY 312
Cdd:cd23989  161 LRVYYTLADVGANQTVLFANPNFLRNVGKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDERTISHHYY 240

                        250       260       270
                 ....*....|....*....|....*....|..
gi 116497115 313 DNVLPFSGFHAMPEEFLQLWYLHKIGALRMQL 344
Cdd:cd23989  241 DNVLPDSGFHAMPEEFLQLWHLHKSGVLRMQL 272
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 73-344 4.67e-172

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 479.45  E-value: 4.67e-172
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115  73 TAARAFRKQMEDCCDPAHLFAMTKMNSPMGKSMWYDGEFLYSFTIDNSTYSLFPQATPFQ-LPLKKCAVVGNGGILKKSG 151
Cdd:cd23971    1 TEHQQFRSELRSCCNASHELVVTQENTPLGSKIHYEGERKKTITVNEKLFSMLPKESPFSnKPLKTCAVVGNGGILKNSS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 152 CGRQIDEANFVMRCNLPPLSseYTKDVGSKSQLVTANPSIIRQRFQNLLWSRKTFVDNMKIYNHSYIYMPAFSMKTGTEP 231
Cdd:cd23971   81 CGREIDSADFVIRCNLPPLN--DSKDVGSKTNLVTANPSILREKFHNLKKRRRPFVERMKVYGNALLLLPAFSYTSNTEP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 232 SLRVYYTLSDVGANQTVLFANPNFLRSIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVAIYGFWPFSVNMHEQPISHHY 311
Cdd:cd23971  159 SLRALYTLEDFGSPQKVLFFNPEYLRNLSRYWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDLDGNPISHHY 238

                        250       260       270
                 ....*....|....*....|....*....|...
gi 116497115 312 YDNVLPFSGFHAMPEEFLQLWYLHKIGALRMQL 344
Cdd:cd23971  239 YDNVLPKKGVHAMPEEFLRYLKLHSQGVLRLHL 271
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 78-344 2.60e-117

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 340.58  E-value: 2.60e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115  78 FRKQMEDCCDPAHLFAMTKMNSPMGKSMWYDGEFLYSFTIDNSTYSLFPQATPFQ-LPLKKCAVVGNGGILKKSGCGRQI 156
Cdd:cd23991    6 FRSELSSCCNAVQNFIVSQNNTPLGTNLTYEVEPKKKILITENIFRMFPKSQPFRgYPYKQCAVVGNGGILKNSSCGAEI 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 157 DEANFVMRCNLPPLSSEYTKDVGSKSQLVTANPSIIRQRFQNLLWSRKTFVDNMKIYNHSYIYMPAFSMKTGTEPSLRVY 236
Cdd:cd23991   86 DQADFVFRCNLPPTGGNISKDVGSKTNLVTANPSIISIKYAKLNERRKPFLETVSVYGDAFLLLPAFSYRSNTALSFKVY 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 237 YTLSDVGANQTVLFANPNFLRSIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVAIYGFWPFSVNMHEQPISHHYYDNVL 316
Cdd:cd23991  166 YTLEDFKAKQKVIFFHPIYLKHLAQFWRSKGVQVYRLSTGLMITSAALELCEEVKLYGFWPFSKNTEGKPISHHYYDNQL 245

                        250       260
                 ....*....|....*....|....*...
gi 116497115 317 PFSGFHAMPEEFLQLWYLHKIGALRMQL 344
Cdd:cd23991  246 PKPGFHSMPKEFYQLLQLHSKGILKLQF 273
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 73-344 1.65e-109

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 320.75  E-value: 1.65e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115  73 TAARAFRKQMEDCCDPAHLFAmTKMNSPMGKSMWYDGEFLYSFTIDNSTYSLFPQATPF-QLPLKKCAVVGNGGILKKSG 151
Cdd:cd23963    1 TALDKFRKELERLLNTRKLFL-TQKNTPLGDVLYYSYFKKKTFKITKSLYELLPKTSPFsHKRYKTCAVVGNSGILLGSG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 152 CGRQIDEANFVMRCNLPPLsSEYTKDVGSKSQLVTANPSIIRQRFQNLL--WSRKTFVDNMKIYNHSYIYMPAFSMKTGT 229
Cdd:cd23963   80 CGKEIDSHDFVIRCNLPPI-KGFEKDVGRKTNLTTLNPSILKRRYNSLKknRDRDKFLNRLKEYNGSILWYPKFSFKSST 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 230 EPSLRVYYTLSDVGANQTVLFANPNFLRSIGKFWKSRGIhAKRLSTGLFLVSAALGLCEEVAIYGFWPFSVNMHEQPISH 309
Cdd:cd23963  159 NLLLKAARALKKNGLNLTVVYSNPEHFLAVQKFWKRRGL-EKRPSTGLYLVSLALTFCDEIHLYGFWPFPTDPNGRPVPY 237

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 116497115 310 HYYDNVLP--FSGFHAMPEEFLQLWYLHKIGALRMQL 344
Cdd:cd23963  238 HYYDDLSPstKNKVHNMPEEFKLLRELHKKGVLKLHT 274
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 94-339 3.32e-103

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 304.14  E-value: 3.32e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115   94 MTKMNSPMGKSMWYdGEFLYSFTIDNSTYSLFPQATPFQ-LPLKKCAVVGNGGILKKSGCGRQIDEANFVMRCNLPPLsS 172
Cdd:pfam00777   2 LTKENFPLGEWIRY-SEWWLPFTVTEELLELLPKVSPFDnKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPT-K 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115  173 EYTKDVGSKSQLVTANP-SIIRQRFQNLLWS--RKTFVDNMKIYNH--SYIYMPAFSMKTGTEPSLRVYYTLSDVGANQT 247
Cdd:pfam00777  80 GYEKDVGSKTTLRTMNPeSAIDSKYGNLGFShpRDPFVEFVLVPFKgrDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPVD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115  248 ---VLFANPNFLRSIGKFW-KSRGIHAKRLSTGLFLVSAALGLCEEVAIYGFWPFsvnMHEQPISHHYYDNVLP----FS 319
Cdd:pfam00777 160 pdkVLFLHPDFLRYVANFWlRSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPF---LDSRGNSHHYYDNVLMkkggFY 236

                         250       260
                  ....*....|....*....|
gi 116497115  320 GFHAMPEEFLQLWYLHKIGA 339
Cdd:pfam00777 237 GVHDMPFEFKLLQKLHKEGV 256
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 73-342 4.13e-96

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 286.73  E-value: 4.13e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115  73 TAARAFRKQMEDCCDPAHLFAMTKMNSPMGKSMWYDGEFLYSFTIDNSTYSLFPQATPF-QLPLKKCAVVGNGGILKKSG 151
Cdd:cd23990    1 TEANAFKSSLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINSEIFKMFPKDMPYsRSQFKKCAVVGNGGILKNSK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 152 CGRQIDEANFVMRCNLPPLSSEYTKDVGSKSQLVTANPSIIRQRFQNLLWSRKTFVDNMKIYNHSYIYMPAFSMKTGTEP 231
Cdd:cd23990   81 CGREIDSADFVFRCNLPPISEKYVRDVGVKTDVVTINPSIITERFHKLEKWRRPFYEVLQVYENASVVLPAFYNTRNTDV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 232 SLRVYYTLSDVGANQTVLFANPNFLRSIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVAIYGFWPFSVNMHEQPISHHY 311
Cdd:cd23990  161 SIRVKYVLDDFESQQAVYYFHPQYLLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNPSGIFITHHY 240

                        250       260       270
                 ....*....|....*....|....*....|.
gi 116497115 312 YDNVLPFSGFHAMPEEFLQLWYLHKIGALRM 342
Cdd:cd23990  241 YDNVKPRPGFHAMPSEIFNFLHMHSRGILRV 271
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 71-344 1.81e-75

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 234.60  E-value: 1.81e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115  71 NQTAARAFRKQMEDCCDPAHLFAMTKMNSPMGKSMWYD-GEFLYSFTIDNSTYSLFPQATPFQ-LPLKKCAVVGNGGILK 148
Cdd:cd23970    2 NKTALLHQRKEIRQYFDVIKNISLTKKDVRIGQLMHFDySSHKYVFSISPNLRSLLPEVSPFQnKHYNTCAVVGNSGILT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 149 KSGCGRQIDEANFVMRCNLPPLSSeYTKDVGSKSQLVTANPSIIRQRFQNLL--WSRKTFVDNMKIYNHSYIYMPAFSMK 226
Cdd:cd23970   82 NSQCGNEIDKSDFVFRCNFAPTEG-FEKDVGRKTNLTTFNPSILEKYYNNLLtiQDRNNFFLSLKKLDGAILWIPAFFFH 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 227 TGTEPSLRVYYTLSDVGANQTVLFANP-NFLRSIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVAIYGFWPFSVNMHEQ 305
Cdd:cd23970  161 TSATVTRTLVDFFVEHRGQLKVQLAWPgNIMQHVNRYWKTKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPTGT 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 116497115 306 PISHHYYDN-----VLPFSGFHAMPEEFLQLWYLHKIGALRMQL 344
Cdd:cd23970  241 PLPYHYYDKkgtkfTTKWQESHQLPAEFVLLYKMHGAGVLKLTL 284
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 73-343 1.73e-69

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 218.82  E-value: 1.73e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115  73 TAARAFRKQMEDCCDPAHLFAMTKMNSPMGKSMWYDGEFLYSFTIDNSTYSLFPQATPFQLPL-KKCAVVGNGGILKKSG 151
Cdd:cd23969    1 TEVLRMRKWILKFFDPEKDISVLKSQVKPGDRMHYEIDRHKTVNITQDLYQLLPEVSPLKGKHfRTCAVVGNSGILLNSG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 152 CGRQIDEANFVMRCNLPPLSsEYTKDVGSKSQLVTANPSIIRQRF---QNLLWSRKtFVDNMKIYNHSYIYMPAFSMKTG 228
Cdd:cd23969   81 CGQEIDSHDFVIRCNLAPVE-GYEKDVGTKSNLTTMNPSVIPHAYgdlVNATDKEK-FVERLRQLGDSILWIPAFVSKGG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 229 TEpslRVYYTLSDV---GANQTVLFANPNFLRSIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVAIYGFWPFSVNMHEQ 305
Cdd:cd23969  159 EE---HVQWTNEIIlkhKLNVKTAYPPLRLNHAIRGYWLTTKFRIKRPSTGLLMYTLATRFCDEIHLYGFYPFSEDGNGR 235

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 116497115 306 PISHHYYDNvLPFS---GFHAMPEEFLQLWYLHKIGALRMQ 343
Cdd:cd23969  236 AVKYHYYDN-RKYLttaRPHKMPEEFRALRSLHQRGALRLH 275
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 114-342 1.30e-56

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 185.91  E-value: 1.30e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 114 SFTIDNSTYSLFPQATPFQ-LPLKKCAVVGNGGILKKSGCGRQIDEANFVMRCNLPPLSsEYTKDVGSKSQLVTANPSII 192
Cdd:cd23987   42 TMNISQNLYELLPRTSPLKnKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVE-EYAKDVGTKTDLVTMNPSVV 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 193 RQRFQNLL---WSRKtFVDNMKIYNHSYIYMPAFSMKTGTEPSLRVYYTLSDVGANQTVLFANPNFLRSIGKFWKSRGIH 269
Cdd:cd23987  121 QRAFEDLVnetWKEK-FLQRLQSLNGSILWIPAFMAKGGEERVEWVNDLILKHHINVRTAYPSLRLLHAVRGYWLTNKVH 199

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 116497115 270 AKRLSTGLFLVSAALGLCEEVAIYGFWPFSVNMHEQPISHHYYDNV----LPFSGFHAMPEEFLQLWYLHKIGALRM 342
Cdd:cd23987  200 IKRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNQNPVKYHYYDSLkygyTSQASPHTMPLEFKALKNLHQQGALKL 276
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 114-342 1.16e-53

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 178.22  E-value: 1.16e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 114 SFTIDNSTYSLFPQATPFQ-LPLKKCAVVGNGGILKKSGCGRQIDEANFVMRCNLPPLSsEYTKDVGSKSQLVTANPSII 192
Cdd:cd23988   42 TLNISQNLHSLLPEVSPMKnRRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVV-EFAADVGTKSDFITMNPSVV 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 193 RQRFQNLL--WSRKTFVDNMKIYNHSYIYMPAFSMKTGTEpslRVYYTLSDVGANQ-TVLFANPNF--LRSIGKFWKSRG 267
Cdd:cd23988  121 QRAFGGFRneSDREKFVHRLSMLNDSVLWIPAFMVKGGEK---HVEWVNALILKNKlKVRTAYPSLrlIHAVRGYWLTNK 197

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 116497115 268 IHAKRLSTGLFLVSAALGLCEEVAIYGFWPFSVNMHEQPISHHYYDNV----LPFSGFHAMPEEFLQLWYLHKIGALRM 342
Cdd:cd23988  198 VNIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDANGNPVKYHYYDDLkyryFSNAGPHRMPLEFKTLNVLHNRGALKL 276
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 138-320 3.53e-26

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 103.21  E-value: 3.53e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 138 CAVVGNGGILKKSGCGRQIDEANFVMRCNLPPlSSEYTKDVGSKSQLvtanpsiirqRFQNLLWSRKtFVDNMKIYNHSY 217
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAP-TKGFEKDVGSKTTF----------RVLNSKWAGF-YLRGPRCGCHPL 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 218 IYM-PAFSMKTGTEPSLRVYYTLSDVGANQTVLFANPNF----------LRSIGKFWKSRGIHAkrlSTGLFLVSAALGL 286
Cdd:cd19952   69 PLEeEVVLILSRAAAADFKRLKRRKKRHDNAVLLLTDPApdllsyvrkrLEKLGLKSFFGGNAP---SSGLLAVLLALQL 145

                        170       180       190
                 ....*....|....*....|....*....|....
gi 116497115 287 CEEVAIYGFWPFSVNMHEQPisHHYYDNVLPFSG 320
Cdd:cd19952  146 CDSVDLYGFGVDSGHAPKVP--YHYYDLVEAEEG 177
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 137-341 3.02e-23

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 97.71  E-value: 3.02e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 137 KCAVVGNGGILKKSGCGRQIDEANFVMRCNLpPLSSEYTKDVGSKSQLVTANP--SIIRQRFQNLLWSRKTFVDNM-KIY 213
Cdd:cd23964   84 RCAVVGNGGILNGSGKGKEIDAHDYVFRVNH-ALTKGFEKDVGTKTSFYTFFPesLHNSLLKHVPQDKDTKYLFIPfKIR 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 214 nhSYIYMPAFS----MKTGTEPSLRVYYTLSDVGANQTVLFANPNFLRSIGKFW-KSRGIHakRLSTGLFLVSAALGLCE 288
Cdd:cd23964  163 --DYDYLDAVLsgkpVPDGCDKGKRPPPLFGPKLNATNVRLLHPDFIRYLFNRWlNSSTSY--RPTTGALMLLTALHTCD 238

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 116497115 289 EVAIYGF---WPFSVnmheqpishHYYDN----VLPFSGFHAMPEEfLQLW-YLHKIGALR 341
Cdd:cd23964  239 QVSVYGFgydPRFSL---------HYYDKtfvkFTVFYANHDFTNE-RKLWrKLHEEGIIN 289
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 137-342 8.26e-17

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 79.80  E-value: 8.26e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 137 KCAVVGNGGILKKSGCGRQIDEANFVMRCNlPPLSSEYTKDVGSKSQLVTANPSIIRQR--------FQNLLWSRKTFVD 208
Cdd:cd23974   86 RCAVVGNGGILNGSRMGAEIDGHDYVFRVN-GAITKGFEKDVGRRTSFYTFSTNTLMNSlrayagvgFNGPPQSKETRYI 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 209 NMKIYNHSYIYMPAFSMKT----GTEPSLR-VYYTLSDVGANQTVLFaNPNFLRSI-GKFWKSRGIHAK-----RLSTGL 277
Cdd:cd23974  165 FLPDHDRDYLLVKAALTHTpidrGRDKSKRpSKYFGKDVTAEKFKIY-HPDFIRYLrNRFLWSPILNTKqrdiyRPSTGA 243

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 116497115 278 FLVSAALGLCEEVAIYGFwpfsVNMHEQPISHHYYDNVLPFSGF---HAMPEEfLQLWY-LHKIGALRM 342
Cdd:cd23974  244 VMLLAALHTCDQVSAYGF----MTPDYGKYSDHYYDKTYHKVVFyanHDLRLE-MQLWQkLHKAGLIKL 307
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 137-342 2.04e-15

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 75.39  E-value: 2.04e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 137 KCAVVGNGGILKKSGCGRQIDEANFVMRCNLPPLSSeYTKDVGSKSQLVTANPsiirQRFQNLLWSRKTFVDNMKIYNHS 216
Cdd:cd23966   79 RCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKG-FEKDVGSKTTHHFMYP----ESAVDLDPGVHLVLVPFKVLDLQ 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 217 YIyMPAFSMKTGTepslRVYYTL-SDVGANQT-VLFANPNFLRSIGKFWKSRgiHAKRLSTGLFLVSAALGLCEEVAIYG 294
Cdd:cd23966  154 WL-ISALTTGEIT----RTYTPVkRFIKADKDkVLVINPAFIKYVHDNWTEH--HGRYPSTGFLALIFALHICDEVSVFG 226

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 295 F-------WpfsvnmheqpisHHYYDNVLPFSGF-----HAMPEEFLQLWYLHKIGALRM 342
Cdd:cd23966  227 FgadskgnW------------HHYWEKNRSAGAFrktgvHDADFESDIIKKLAKEGKIRV 274
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 130-317 2.25e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 71.82  E-value: 2.25e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 130 PFQLPLKKCAVVGNGGILKKSGCGRQIDEANFVMRCNLPPlSSEYTKDVGSKSQL-VTANPS---IIRQRFQNLLWSRKT 205
Cdd:cd23976   10 PLKMHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAP-TRGYGKDVGNKTSLrVIAHSSiqrILRNRNELLNVSQGT 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 206 FV------DNMK------IYNHsyiympaFSMKTGTEPSLRVYytlsdVGANQTVLFANPNFLRSIGKfwkSRGIHAKRL 273
Cdd:cd23976   89 VFifwgpsNYMRrdgkglVYNN-------LQLMNQILPKLKVY-----TITRHKMLQFDELFKRETGK---DRKISNTWL 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 116497115 274 STGLFLVSAALGLCEEVAIYGFWP--FSVNMHEQPISHHYYDNVLP 317
Cdd:cd23976  154 STGWFTMIIALELCDRINVYGMVPpdFCRDPNHPSVPYHYYEPSGP 199
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 136-314 3.51e-14

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 71.84  E-value: 3.51e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 136 KKCAVVGNGGILKKSGCGRQIDEANFVMRCNLPPlSSEYTKDVGSKSQLVTANPSIIRQRFQN---LLWSRKTF------ 206
Cdd:cd23980   82 RRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAP-TEGFEADVGSKTTHHFVYPESFRELAQNvsmILVPFKTLdlewvi 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 207 -VDNMKIYNHSYIYMPAfsmktgtepSLRVyytlsdvgANQTVLFANPNFLRSIGKFWKSRgiHAKRLSTGLFLVSAALG 285
Cdd:cd23980  161 sATTTGTISHTYVPVPR---------KIKV--------KKEKILIYHPAFIKYVFDRWLQG--HGRYPSTGILSVIFSLH 221

                        170       180
                 ....*....|....*....|....*....
gi 116497115 286 LCEEVAIYGFWPFSvnmheQPISHHYYDN 314
Cdd:cd23980  222 VCDEVDLYGFGADS-----KGNWHHYWEN 245
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 118-342 2.31e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 69.85  E-value: 2.31e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 118 DNSTYSLFPqatPFQLPLK--KCAVVGNGGILKKSGCGRQIDEANFVMRCNlPPLSSEYTKDVGSKSQLV-----TANPS 190
Cdd:cd23972   66 DSANAKLFF---PRDTPGKciRCAVVGNGGILNGSRQGRAIDAHDYVFRLN-GAVIKGFEEDVGTKTSFYgftvnTMKNS 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 191 IIrqRFQNLLWSRKTFVDNMKiynhsYIYMPAfsmktgtepSLRVYYTLS------------DVGANQTVLFA------- 251
Cdd:cd23972  142 LI--SYWNLGFTRTPQGQDLQ-----YIFIPS---------DIRDYVMLRsailgvpvpeglDKGDRPHKYFGpeasakk 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 252 ----NPNFLRSI-GKFWKSRGI-----HAKRLSTGLFLVSAALGLCEEVAIYGFwpfsVNMHEQPISHHYYDNV---LPF 318
Cdd:cd23972  206 fkllHPDFISYLtDRFLKSKLLnthygHLYMPSTGALMLLTALHTCDQVSAYGF----ITSNYWKFSDHYYERKkkpLVF 281

                        250       260
                 ....*....|....*....|....*
gi 116497115 319 SGFHAMPEEfLQLW-YLHKIGALRM 342
Cdd:cd23972  282 YANHDMLLE-AALWrRLHKAGILQL 305
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 134-337 3.11e-13

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 67.70  E-value: 3.11e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 134 PLKKCAVVGNGGILKKSGCGRQIDEANFVMRCNLPPLSSeYTKDVGSKSQLVTANP-SIIRQRFQN-------------- 198
Cdd:cd23967    1 SCRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKG-YEKDVGSKTTFRMFYPeSAFRDPEEYdsdwllvlvpfksm 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 199 -LLWsRKTFVDNMKIYNHSyiympaFSMKtgtEPSLRVyytlsDVGANQTVLFaNPNFLRS----IGKFWKSRGIHAKRL 273
Cdd:cd23967   80 dLLW-LQAVIKGKKPNGKG------GFWK---KIATSV-----PKPPKKIRIL-NPYILQEaafdLIGLPMNGKQGKNVP 143

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 116497115 274 STGLFLVSAALGLCEEVAIYGFwPFSVNMHEQPIshHYYDNVL----PFSGFHAMPEEFLqlwYLHKI 337
Cdd:cd23967  144 TTGIIAIVMALHYCDEVDIAGF-GYDPSDPNAPL--HYYDSLTmkaiKRSWTHNVTKEKK---YLKKL 205
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 136-314 1.69e-12

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 66.82  E-value: 1.69e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 136 KKCAVVGNGGILKKSGCGRQIDEANFVMRCNLPPlSSEYTKDVGSKS----------QLVTANPSIIRQRFQ--NLLWsr 203
Cdd:cd23979   81 RRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAP-TVGFEADVGSRTthhfmypesaKNLPANVSFVLVPFKtlDLLW-- 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 204 ktFVDNMKIYNHSYIYMPafsmktgTEPSLRVyytlsdvgANQTVLFANPNFLRSIGKFWKSRgiHAKRLSTGLFLVSAA 283
Cdd:cd23979  158 --ITSALSTGQIRFTYAP-------VKQFLRV--------DKDKVQIYNPAFFKYIHDRWTEH--HGRYPSTGMLVLFFA 218

                        170       180       190
                 ....*....|....*....|....*....|.
gi 116497115 284 LGLCEEVAIYGFWPFSvnmheQPISHHYYDN 314
Cdd:cd23979  219 LHVCDEVNVYGFGADS-----RGNWHHYWEN 244
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 137-342 2.20e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 67.08  E-value: 2.20e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 137 KCAVVGNGGILKKSGCGRQIDEANFVMRCNlPPLSSEYTKDVGSKS-------QLVTANPSIIRQR-FQNLLWSRKT--- 205
Cdd:cd23973   85 RCAVVGNGGILNGSKMGQEIDSHDYVFRVN-GAVIKGYEEDVGTRTsfyvhtaHSITSSLMILQKRgFKNIPQDKDIkyi 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 206 -FVDNMKIYNhsyiYMPAFsMKTGTEPS--LRVYYTLSDVGANQT---VLFANPNFLRSI-GKFWKSRGIHAK-----RL 273
Cdd:cd23973  164 lFPEGPRDYQ----WLEAL-LKNKTIPSgaYYGRRPRSYFSGDFTedkYLVLHPDFLRYVkNRFLRSKTLKGKywaiyRP 238

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 116497115 274 STGLFLVSAALGLCEEVAIYGFwpfsvnMHE--QPISHHYYDNV---LPFSGFHAMPEEfLQLW-YLHKIGALRM 342
Cdd:cd23973  239 TTGAFLLLTALHLCDTVSAYGF------ITEdyRKYPDHYYDKKktkLVFYINHDFRLE-KKLWkRLHDEKIIKL 306
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 136-313 1.45e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 63.34  E-value: 1.45e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 136 KKCAVVGNGGILKKSGCGRQIDEANFVMRCNLPPlSSEYTKDVGSKSQLV----TANPSIIRQR---FQN------LLW- 201
Cdd:cd23977    2 RRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAP-TAGYEADVGNRSSLRvvshTSVPLLLRNQgyfFQQsrdtkyVIWg 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 202 -SRK-TFVDNMKIYNhsyiympAFSMKTGTEPSLRVyYTLSDvganQTVLFANPNFLRSIGkfwKSRGIHAKRLSTGLFL 279
Cdd:cd23977   81 pERNmDRDGGGKTYR-------ALLTLAKMYPHLQV-YTLTE----EKMAYCDGVFQNETG---KNRMKSGSFLSTGWFT 145

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 116497115 280 VSAALGLCEEVAIYGFWPFSV--NMHEQPISHHYYD 313
Cdd:cd23977  146 MILALELCEEILVYGMVSDSYcrNKNHSSVPYHYYE 181
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 136-313 3.74e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 62.26  E-value: 3.74e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 136 KKCAVVGNGGILKKSGCGRQIDEANFVMRCNLPPLSSeYTKDVGSKSQL-VTANPSIIRQRFQNLLWSRKTFVDNMKIyn 214
Cdd:cd23965    2 DTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRG-YEKDVGRRTTIrVVSHSSLPRLLRNAILLLAGTRAPTVVV-- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 215 hsyIYMPAFSMKTGTEPSLRV------------YYTLSDVGanqtVLFANPNFLRSIGkfwKSRGIHAKRLSTGLFLVSA 282
Cdd:cd23965   79 ---FWGPETKMNKDGAGKYNLlrslskkypdveFYSLTPEK----MDYADELFEKETG---KSRIKSGTWLSTGWFTMLL 148

                        170       180       190
                 ....*....|....*....|....*....|...
gi 116497115 283 ALGLCEEVAIYGFWP--FSVNMHEQPISHHYYD 313
Cdd:cd23965  149 ALDVCDEIKVYGMVPenYCREHPNSKVPYHYYE 181
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 134-316 7.36e-11

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 60.83  E-value: 7.36e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 134 PLKKCAVVGNGGILKKSGCGRQIDEANFVMRCNLPPLsSEYTKDVGSKSQL-------VTANPSIIRQ----------RF 196
Cdd:cd23982    1 RCRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPV-RGFEKDVGSKTTIrlfypesAQFDPGIENDpdtllvlvpfKP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 197 QNLLWSRKTFVDNMKIynhsyiympafsMKTGTEPSLRVYytlsDVGANQT-VLfaNPNFLRSIG-KFWKSRGIHAK--R 272
Cdd:cd23982   80 LDFYWLYEILSNEKRV------------RKGFWKQPPRIW----DANPKQIrIL--NPYYTYVAAtKLLQVPGQRKKkqK 141

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 116497115 273 LSTGLFLVSAALGLCEEVAIYGF-WPFSVNmHEQPIshHYYDNVL 316
Cdd:cd23982  142 PTTGLLAITLALHLCDEVHIAGFgYPDNGN-SNQPI--HYYNQIT 183
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 122-327 1.42e-10

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 61.13  E-value: 1.42e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 122 YSLFPQATPFQLPLKKCAVVGNGGILKKSGCGRQIDEANFVMRCNLPPLsSEYTKDVGSK-------SQLVTAN-----P 189
Cdd:cd23968   32 YPFPESSLENTKRYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPT-KGFEKDVGSKttlrlinSQILSKPefnflT 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 190 SIIRQRFQNLLWSRKTFVDNMKI--YNHSYIYMPAFSMKTGTEPSLRVYytlsdvganqtvlFANPNFLRsigKFWK--- 264
Cdd:cd23968  111 DPLYRNVTLLVWDPSSYNVNLEKwyKKPDFDFFPNYIKYRRRHPEEPFY-------------LIDPRFLW---RLWDilq 174

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 265 ---SRGIHAKRLSTGLFLVSAALGLCEEVAIYGFWPfSVNMHEQpisHHYYDNVL----PFSGFHAMPEE 327
Cdd:cd23968  175 eytPEKIKPNPPSSGFIGIVLMLHLCDWVDVYEYVP-SVRQTDR---CHYYDVEKdlacTLGAWHPLAAE 240
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 134-315 1.71e-10

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 59.76  E-value: 1.71e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 134 PLKKCAVVGNGGILKKSGCGRQIDEANFVMRCNLPPLSSeYTKDVGSKSQLVTANP-SIIRQRFQNllwSRKTFVDNMKI 212
Cdd:cd23984    1 SCKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIG-YENDVGKRTTFRLCYPeSIFSDPSHY---DPNTTVVLIPF 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 213 YNHSYIYMPAFSMK-----TG--TEPSLRVYYTLSDVganqTVLfaNPNFLRSIGKFW---------KSRGIHAkrlSTG 276
Cdd:cd23984   77 KPHDLRWLLDLLMGkkvsaKGfwKKPALNLIYKPNQI----RIL--NPFILRIAAYELlhfpkrfpkEKKPKHP---TTG 147

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 116497115 277 LFLVSAALGLCEEVAIYGfwpFSVNMHEQPISHHYYDNV 315
Cdd:cd23984  148 IIAITLALHICNEVHIAG---FKYDFSNLNSTLHYYGNE 183
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 136-315 1.15e-09

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 57.62  E-value: 1.15e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 136 KKCAVVGNGGILKKSGCGRQIDEANFVMRCNLPPLSSeYTKDVGSKSQLVTANPSIIRQRFQNLLWSRKTFVDNMKIYNH 215
Cdd:cd23981    3 RRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKG-FEKDVGSKTTLRITYPEGAIQKPEQYEKDSLFVLAGFKWQDF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 216 SY----IYMPAFSMKTGTEPSLRVYYTlsdvGANQTVLFANPNFLRS-----IGKFWKSRGIHAKRLST-GLFLVSAALG 285
Cdd:cd23981   82 KWlkyiVYKEKVSASDGFWKSVATRVP----REPHEIRILNPYFIQEaafsfIGLPFNNGLMGRGNIPTlGSVAITMALH 157

                        170       180       190
                 ....*....|....*....|....*....|
gi 116497115 286 LCEEVAIYGFwPFSVNMHEQPIshHYYDNV 315
Cdd:cd23981  158 NCDEVAVAGF-GYDMNTPNAPL--HYYETI 184
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 137-313 2.63e-09

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 56.79  E-value: 2.63e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 137 KCAVVGNGGILKKSGCGRQIDEANFVMRCNLPPLSSeYTKDVGSKSQL-VTANPSIIR-----QRFQNLLwSRKTFVdnm 210
Cdd:cd23978    3 QCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTG-YEKDVGNKTTLrVVAHSSVYRvlrrpQEFLNRT-PETTLI--- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 211 kiynhsyIYMPAFSMKTGTEPSL-RVYYTLSDVGANQTVLFANPNFLRSIGKFW-----KSRGIHAKRLSTGLFLVSAAL 284
Cdd:cd23978   78 -------FWGPPNKMQKDGKSNLfRIIQRASMTFPNMSAFVVSPRRMRQFDDLFrgetgRDRKKSHSWLSTGWFTMVIAV 150

                        170       180       190
                 ....*....|....*....|....*....|..
gi 116497115 285 GLCEEVAIYGFWPF---SVNMHEQPISHHYYD 313
Cdd:cd23978  151 ELCDNVHVYGMVPPnycSKRPTPKKMPYHYYE 182
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 134-186 6.57e-09

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 56.25  E-value: 6.57e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 134 PLKKCAVVGNGGILKKSGCGRQIDEANFVMRCNLPPlSSEYTKDVGSK-------SQLVT 186
Cdd:cd23985   44 PLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAP-TAGFQQDVGTKttirlinSQLVT 102
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 134-315 8.51e-09

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 55.13  E-value: 8.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 134 PLKKCAVVGNGGILKKSGCGRQIDEANFVMRCNLPPLSSeYTKDVGSKSQLVTANP-----SIIRQRFQNL--------- 199
Cdd:cd23983    1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQG-YSQDVGNKTTIRMTYPegapkSEQEYDPTSLfvavlfksv 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 200 ---------------LWSRKTF-----------VDNMKIYNHSYIYMPAFSMKTGTEPSLRvyytlsdvganqtvlfanp 253
Cdd:cd23983   80 dfawlkamvkkeplsFWSRLFFwkevadsiplkPSQFRILNPLIIKETALDILQYPEPQSR------------------- 140

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 116497115 254 nflrsigkFWKSRGIHAkrlSTGLFLVSAALGLCEEVAIYGfwpFSVNMHEQPISHHYYDNV 315
Cdd:cd23983  141 --------LWGWDKNVP---TLGVTAVVLATHLCDEVSLAG---FGYDLSQPHAPLHYYDSV 188
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 135-329 3.96e-07

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 50.61  E-value: 3.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 135 LKKCAVVGNGGILKKSGCGRQIDEANFVMRCNLPPlSSEYTKDVGSKSQLVTANPSII---RQRFQN---------LLWS 202
Cdd:cd23986   49 FRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAP-TRGYEKDVGNKTTIRIINSQILtnpNHHFIDsslykdvilVAWD 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 203 RKTFVDNMKIYNHSyiymPAFSMKTgtePSLRvyYTLSDvgANQTVLFANPNFlrsIGKFWK------SRGIHAKRLSTG 276
Cdd:cd23986  128 PAPYSANLHKWYKK----PDYNLFT---PYVQ--YRKRN--PNQPFYILHPKF---IWQLWDiiqentQEKIQPNPPSSG 193

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 116497115 277 LFLVSAALGLCEEVAIYGFWPfsvNMHEQPISHH---YYDNVLPFSGFHAMPEEFL 329
Cdd:cd23986  194 FIGILIMMSMCREVHVYEYIP---SVRQTDLCHYherYYDAACTLGAYHPLLYEKL 246
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 138-313 5.79e-04

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 40.69  E-value: 5.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 138 CAVVGNGGILKKSGCGRQIDEANFVMRCNLPPlSSEYTKDVGSKSQ----------LVTANPSIIRQRFQNLLWSRKTFV 207
Cdd:cd23975    4 CAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAP-TKGYEEDVGKRTTirvvshtsvpLLLKNPDYFFKETNETIYVIWGPF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116497115 208 DNMKIYNHSYIYmPAFSMKTGTEPSLRVYYTlsdvgANQTVLFANPNFLRSIGkfwKSRGIHAKRLSTGLFLVSAALGLC 287
Cdd:cd23975   83 RNMRKDGKGIVY-NMLKKAVESYPQAKIYVT-----TEKRMSYCDTVFKKETG---KDRVQSGSYLSTGWFTLILAMDAC 153

                        170       180
                 ....*....|....*....|....*...
gi 116497115 288 EEVAIYGFWPFSVNMHE--QPISHHYYD 313
Cdd:cd23975  154 YGIHVYGMINDTYCKTEgyRKVPYHYYE 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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