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Conserved domains on  [gi|115304784|gb|AAI23506|]
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Usher syndrome 1C binding protein 1 [Bos taurus]

Protein Classification

MCC-bdg_PDZ domain-containing protein( domain architecture ID 10564712)

MCC-bdg_PDZ domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MCC-bdg_PDZ pfam10506
PDZ domain of MCC-2 bdg protein for Usher syndrome; The protein has a high homology to the ...
 294-358 1.46e-21

PDZ domain of MCC-2 bdg protein for Usher syndrome; The protein has a high homology to the tumour suppressor MCC (mutated in colon cancer; or MCC1 hereafter) and was named MCC2. MCC2 protein binds the first PDZ domain of AIE-75 with its C-terminal amino acids -DTFL. A possible role of MCC2 as a tumor suppressor has been put forward. The carboxyl terminus of the predicted protein was DTFL which matched the consensus motif X-S/T-X-phi (phi: hydrophobic amino acid residue) for binding to the PDZ domain of AIE-75.


:

Pssm-ID: 463122 [Multi-domain]  Cd Length: 65  Bit Score: 88.53  E-value: 1.46e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 115304784  294 KLRGNIEKLKCFNRLLSAVLQEYKGRCEGLSMQLGQQEAEATALRLALQYSEHCEEAYSALLTLR 358
Cdd:pfam10506   1 RLQRRIEELKSQNELLSLTLEERKQQSEELSLLLGKYESNATALRLALEYSERCKEAYEVLLALV 65
Smc super family cl34174
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 476-685 3.11e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG1196:

Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.08  E-value: 3.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115304784 476 QIQQDLAATRETLEDLMLQLQLVRREKRALELREAALRAQgpahvllLEQLRWERAQLRTGEANSSGGDSSGGGSTGDEE 555
Cdd:COG1196  236 ELEAELEELEAELEELEAELEELEAELAELEAELEELRLE-------LEELELELEEAQAEEYELLAELARLEQDIARLE 308

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115304784 556 EwpqgppavpggsRGIDGGQVSkmqdpEELTQELSASLTRALGLREQLQSLREELEEVARKGRARRAQSAELNSDLCKAH 635
Cdd:COG1196  309 E------------RRRELEERL-----EELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAE 371

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 115304784 636 STLVMAFRGAHRKQEEQRRKLEQQMTLmEARQAEELAVLEATARALERSR 685
Cdd:COG1196  372 AELAEAEEELEELAEELLEALRAAAEL-AAQLEELEEAEEALLERLERLE 420
 
Name Accession Description Interval E-value
MCC-bdg_PDZ pfam10506
PDZ domain of MCC-2 bdg protein for Usher syndrome; The protein has a high homology to the ...
 294-358 1.46e-21

PDZ domain of MCC-2 bdg protein for Usher syndrome; The protein has a high homology to the tumour suppressor MCC (mutated in colon cancer; or MCC1 hereafter) and was named MCC2. MCC2 protein binds the first PDZ domain of AIE-75 with its C-terminal amino acids -DTFL. A possible role of MCC2 as a tumor suppressor has been put forward. The carboxyl terminus of the predicted protein was DTFL which matched the consensus motif X-S/T-X-phi (phi: hydrophobic amino acid residue) for binding to the PDZ domain of AIE-75.


Pssm-ID: 463122 [Multi-domain]  Cd Length: 65  Bit Score: 88.53  E-value: 1.46e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 115304784  294 KLRGNIEKLKCFNRLLSAVLQEYKGRCEGLSMQLGQQEAEATALRLALQYSEHCEEAYSALLTLR 358
Cdd:pfam10506   1 RLQRRIEELKSQNELLSLTLEERKQQSEELSLLLGKYESNATALRLALEYSERCKEAYEVLLALV 65
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 476-685 3.11e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.08  E-value: 3.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115304784 476 QIQQDLAATRETLEDLMLQLQLVRREKRALELREAALRAQgpahvllLEQLRWERAQLRTGEANSSGGDSSGGGSTGDEE 555
Cdd:COG1196  236 ELEAELEELEAELEELEAELEELEAELAELEAELEELRLE-------LEELELELEEAQAEEYELLAELARLEQDIARLE 308

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115304784 556 EwpqgppavpggsRGIDGGQVSkmqdpEELTQELSASLTRALGLREQLQSLREELEEVARKGRARRAQSAELNSDLCKAH 635
Cdd:COG1196  309 E------------RRRELEERL-----EELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAE 371

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 115304784 636 STLVMAFRGAHRKQEEQRRKLEQQMTLmEARQAEELAVLEATARALERSR 685
Cdd:COG1196  372 AELAEAEEELEELAEELLEALRAAAEL-AAQLEELEEAEEALLERLERLE 420
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 563-685 9.61e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 39.27  E-value: 9.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115304784   563 AVPGGSRGIDGGQVSKMQDPEELTQELSASLTRALGLREQLQSLREELEEVARKGRARRAQSAELNSDLCKAHSTLvmaf 642
Cdd:TIGR02168  660 VITGGSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDL---- 735

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 115304784   643 rgahRKQEEQRRKLEQQMTLMEARQAEELAVLEATARALERSR 685
Cdd:TIGR02168  736 ----ARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAE 774
 
Name Accession Description Interval E-value
MCC-bdg_PDZ pfam10506
PDZ domain of MCC-2 bdg protein for Usher syndrome; The protein has a high homology to the ...
 294-358 1.46e-21

PDZ domain of MCC-2 bdg protein for Usher syndrome; The protein has a high homology to the tumour suppressor MCC (mutated in colon cancer; or MCC1 hereafter) and was named MCC2. MCC2 protein binds the first PDZ domain of AIE-75 with its C-terminal amino acids -DTFL. A possible role of MCC2 as a tumor suppressor has been put forward. The carboxyl terminus of the predicted protein was DTFL which matched the consensus motif X-S/T-X-phi (phi: hydrophobic amino acid residue) for binding to the PDZ domain of AIE-75.


Pssm-ID: 463122 [Multi-domain]  Cd Length: 65  Bit Score: 88.53  E-value: 1.46e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 115304784  294 KLRGNIEKLKCFNRLLSAVLQEYKGRCEGLSMQLGQQEAEATALRLALQYSEHCEEAYSALLTLR 358
Cdd:pfam10506   1 RLQRRIEELKSQNELLSLTLEERKQQSEELSLLLGKYESNATALRLALEYSERCKEAYEVLLALV 65
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 476-685 3.11e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.08  E-value: 3.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115304784 476 QIQQDLAATRETLEDLMLQLQLVRREKRALELREAALRAQgpahvllLEQLRWERAQLRTGEANSSGGDSSGGGSTGDEE 555
Cdd:COG1196  236 ELEAELEELEAELEELEAELEELEAELAELEAELEELRLE-------LEELELELEEAQAEEYELLAELARLEQDIARLE 308

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115304784 556 EwpqgppavpggsRGIDGGQVSkmqdpEELTQELSASLTRALGLREQLQSLREELEEVARKGRARRAQSAELNSDLCKAH 635
Cdd:COG1196  309 E------------RRRELEERL-----EELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAE 371

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 115304784 636 STLVMAFRGAHRKQEEQRRKLEQQMTLmEARQAEELAVLEATARALERSR 685
Cdd:COG1196  372 AELAEAEEELEELAEELLEALRAAAEL-AAQLEELEEAEEALLERLERLE 420
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 563-685 9.61e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 39.27  E-value: 9.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115304784   563 AVPGGSRGIDGGQVSKMQDPEELTQELSASLTRALGLREQLQSLREELEEVARKGRARRAQSAELNSDLCKAHSTLvmaf 642
Cdd:TIGR02168  660 VITGGSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDL---- 735

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 115304784   643 rgahRKQEEQRRKLEQQMTLMEARQAEELAVLEATARALERSR 685
Cdd:TIGR02168  736 ----ARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAE 774
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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