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Conserved domains on  [gi|111600588|gb|AAI19248|]
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Seminal vesicle secretory protein 6 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Svs_4_5_6 super family cl38663
Seminal vesicle secretory proteins 4/5/6; There are seven major proteins involved in murine ...
 42-95 1.27e-07

Seminal vesicle secretory proteins 4/5/6; There are seven major proteins involved in murine seminal vesicle secretion (SVS1-7). Mouse Svs2-Svs6 genes evolved by gene duplication and belong to the same gene family. This domain family is found in SVS4/5 and 6. SVS4 is a basic, thermostable, secretory protein synthesized by rat seminal vesicle epithelium under strict androgen transcriptional control. This protein has potent nonspecies-specific immunomodulatory, anti-inflammatory, and pro-coagulant activities that have been shown to be located in the N-terminal region of Svs4 (fragment 1-70). The N-terminal segment has a high amino-acid sequence similarity with the C-terminal segment 34-66 of uteroglobin, a rabbit steroid-inducible, cytokine-like, multifunctional, secreted protein. Furthermore, SVS4 acts as a sperm capacitation inhibitor, by interacting with SVS3 and SVS2.


The actual alignment was detected with superfamily member pfam17381:

Pssm-ID: 375165  Cd Length: 91  Bit Score: 45.50  E-value: 1.27e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 111600588  42 ANSPKSIVHEEVYEEKKFKRNMV--NGEDGEDSKRASAGEIERSYLRKKeKQRFAQ 95
Cdd:pfam17381 37 SKSPSSIIGEEVSEESSSRRSMSisSSSDGSNMRRSSAGEGESSYAKKK-KSRFAQ 91
 
Name Accession Description Interval E-value
Svs_4_5_6 pfam17381
Seminal vesicle secretory proteins 4/5/6; There are seven major proteins involved in murine ...
 42-95 1.27e-07

Seminal vesicle secretory proteins 4/5/6; There are seven major proteins involved in murine seminal vesicle secretion (SVS1-7). Mouse Svs2-Svs6 genes evolved by gene duplication and belong to the same gene family. This domain family is found in SVS4/5 and 6. SVS4 is a basic, thermostable, secretory protein synthesized by rat seminal vesicle epithelium under strict androgen transcriptional control. This protein has potent nonspecies-specific immunomodulatory, anti-inflammatory, and pro-coagulant activities that have been shown to be located in the N-terminal region of Svs4 (fragment 1-70). The N-terminal segment has a high amino-acid sequence similarity with the C-terminal segment 34-66 of uteroglobin, a rabbit steroid-inducible, cytokine-like, multifunctional, secreted protein. Furthermore, SVS4 acts as a sperm capacitation inhibitor, by interacting with SVS3 and SVS2.


Pssm-ID: 375165  Cd Length: 91  Bit Score: 45.50  E-value: 1.27e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 111600588  42 ANSPKSIVHEEVYEEKKFKRNMV--NGEDGEDSKRASAGEIERSYLRKKeKQRFAQ 95
Cdd:pfam17381 37 SKSPSSIIGEEVSEESSSRRSMSisSSSDGSNMRRSSAGEGESSYAKKK-KSRFAQ 91
 
Name Accession Description Interval E-value
Svs_4_5_6 pfam17381
Seminal vesicle secretory proteins 4/5/6; There are seven major proteins involved in murine ...
 42-95 1.27e-07

Seminal vesicle secretory proteins 4/5/6; There are seven major proteins involved in murine seminal vesicle secretion (SVS1-7). Mouse Svs2-Svs6 genes evolved by gene duplication and belong to the same gene family. This domain family is found in SVS4/5 and 6. SVS4 is a basic, thermostable, secretory protein synthesized by rat seminal vesicle epithelium under strict androgen transcriptional control. This protein has potent nonspecies-specific immunomodulatory, anti-inflammatory, and pro-coagulant activities that have been shown to be located in the N-terminal region of Svs4 (fragment 1-70). The N-terminal segment has a high amino-acid sequence similarity with the C-terminal segment 34-66 of uteroglobin, a rabbit steroid-inducible, cytokine-like, multifunctional, secreted protein. Furthermore, SVS4 acts as a sperm capacitation inhibitor, by interacting with SVS3 and SVS2.


Pssm-ID: 375165  Cd Length: 91  Bit Score: 45.50  E-value: 1.27e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 111600588  42 ANSPKSIVHEEVYEEKKFKRNMV--NGEDGEDSKRASAGEIERSYLRKKeKQRFAQ 95
Cdd:pfam17381 37 SKSPSSIIGEEVSEESSSRRSMSisSSSDGSNMRRSSAGEGESSYAKKK-KSRFAQ 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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