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Conserved domains on  [gi|79158603|gb|AAI07986|]
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Srp72 protein, partial [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 187-431 6.24e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 60.13  E-value: 6.24e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603 187 GELGQAMKKLQKAEELCRKSLAEDSDmtEEDIDAELAVIHSQmayviqlQGRTEDALQLYSQVIKLKPSDVGLLAvtanN 266
Cdd:COG2956  49 GNLYRRRGEYDRAIRIHQKLLERDPD--RAEALLELAQDYLK-------AGLLDRAEELLEKLLELDPDDAEALR----L 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603 267 IITINKDQNvfdskkkvKLTNAEGVEHKLAKKQLQAIEI--NKALLAMYTNQADQCNKLLSSLQTQNPTHPRPVLIQVAQ 344
Cdd:COG2956 116 LAEIYEQEG--------DWEKAIEVLERLLKLGPENAHAycELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAEL 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603 345 LCREKQHSKAIELLQRFSDQHPESASGIKLtMAQLYLTQGHVTKACDILKSIEEFKYKPGMISALITMYTHEEDIDSAID 424
Cdd:COG2956 188 YLEQGDYEEAIAALERALEQDPDYLPALPR-LAELYEKLGDPEEALELLRKALELDPSDDLLLALADLLERKEGLEAALA 266


                ....*..
gi 79158603 425 VFSQAIQ 431
Cdd:COG2956 267 LLERQLR 273
SRP_TPR_like super family cl25252
Putative TPR-like repeat; This is a family of microsporidial sequences that are likely to fold ...
 46-151 1.85e-08

Putative TPR-like repeat; This is a family of microsporidial sequences that are likely to fold into a TPR-like structure. Many sequences are annotated as being signal recognition proteins.


The actual alignment was detected with superfamily member pfam17004:

Pssm-ID: 435703 [Multi-domain]  Cd Length: 109  Bit Score: 52.39  E-value: 1.85e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603    46 RCKIVCLIQNGGFKEALnvinthtkSLTSDMiGFEKAYCEYRLNRVENALKTIQGIpeQTDKLKELYGQVLYRLERYDEc 125
Cdd:pfam17004  18 RFKVIALIHLDKYKEAL--------KYAKKG-SFEKAYALYKLKKYKKALKILRKM--DSEGSRVLASQCLYFLGYYNK- 85

                          90       100
                  ....*....|....*....|....*.
gi 79158603   126 laVYKDLirnSQDEYEEERKTNLSAV 151
Cdd:pfam17004  86 --AYKIL---SECKRDDEIVVNLQAM 106
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 187-431 6.24e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 60.13  E-value: 6.24e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603 187 GELGQAMKKLQKAEELCRKSLAEDSDmtEEDIDAELAVIHSQmayviqlQGRTEDALQLYSQVIKLKPSDVGLLAvtanN 266
Cdd:COG2956  49 GNLYRRRGEYDRAIRIHQKLLERDPD--RAEALLELAQDYLK-------AGLLDRAEELLEKLLELDPDDAEALR----L 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603 267 IITINKDQNvfdskkkvKLTNAEGVEHKLAKKQLQAIEI--NKALLAMYTNQADQCNKLLSSLQTQNPTHPRPVLIQVAQ 344
Cdd:COG2956 116 LAEIYEQEG--------DWEKAIEVLERLLKLGPENAHAycELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAEL 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603 345 LCREKQHSKAIELLQRFSDQHPESASGIKLtMAQLYLTQGHVTKACDILKSIEEFKYKPGMISALITMYTHEEDIDSAID 424
Cdd:COG2956 188 YLEQGDYEEAIAALERALEQDPDYLPALPR-LAELYEKLGDPEEALELLRKALELDPSDDLLLALADLLERKEGLEAALA 266


                ....*..
gi 79158603 425 VFSQAIQ 431
Cdd:COG2956 267 LLERQLR 273
SRP_TPR_like pfam17004
Putative TPR-like repeat; This is a family of microsporidial sequences that are likely to fold ...
 46-151 1.85e-08

Putative TPR-like repeat; This is a family of microsporidial sequences that are likely to fold into a TPR-like structure. Many sequences are annotated as being signal recognition proteins.


Pssm-ID: 435703 [Multi-domain]  Cd Length: 109  Bit Score: 52.39  E-value: 1.85e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603    46 RCKIVCLIQNGGFKEALnvinthtkSLTSDMiGFEKAYCEYRLNRVENALKTIQGIpeQTDKLKELYGQVLYRLERYDEc 125
Cdd:pfam17004  18 RFKVIALIHLDKYKEAL--------KYAKKG-SFEKAYALYKLKKYKKALKILRKM--DSEGSRVLASQCLYFLGYYNK- 85

                          90       100
                  ....*....|....*....|....*.
gi 79158603   126 laVYKDLirnSQDEYEEERKTNLSAV 151
Cdd:pfam17004  86 --AYKIL---SECKRDDEIVVNLQAM 106
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 21-500 6.10e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 52.39  E-value: 6.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603    21 NGDFTRALKAVNKILHENKDDVTALRCKIVCLIQNGGFKEALNVINTHTKsLTSDMIG--FEKAYCEYRLNRVENALKTI 98
Cdd:TIGR02917 172 ENRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIA-LRPNNIAvlLALATILIEAGEFEEAEKHA 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603    99 QGIPEQT-DKLKELYgqvlyrlerydeclavYKDLIRNSQDEYEEERkTNLSAVLAAQStwentppedlglpeSSYELCY 177
Cdd:TIGR02917 251 DALLKKApNSPLAHY----------------LKALVDFQKKNYEDAR-ETLQDALKSAP--------------EYLPALL 299

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603   178 NAACCLIGQGELGQAMKKLQKAEelcrkslaedsDMTEEDIDAELavihsqMAYVIQL-QGRTEDALQLYSQVIKLKPSD 256
Cdd:TIGR02917 300 LAGASEYQLGNLEQAYQYLNQIL-----------KYAPNSHQARR------LLASIQLrLGRVDEAIATLSPALGLDPDD 362

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603   257 VGLLAVtANNIITINKDqnvFDSKKKVkLTNAEGVEHKLAKKQLQaieinKALLAMYTNQADQCNKLLSSLQTQNPTHPR 336
Cdd:TIGR02917 363 PAALSL-LGEAYLALGD---FEKAAEY-LAKATELDPENAAARTQ-----LGISKLSQGDPSEAIADLETAAQLDPELGR 432

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603   337 PVLIQVAQLCREKQHSKAIELLQRFSDQHPESASGIKLtMAQLYLTQGHVTKACDILKsiEEFKYKPGMISALI---TMY 413
Cdd:TIGR02917 433 ADLLLILSYLRSGQFDKALAAAKKLEKKQPDNASLHNL-LGAIYLGKGDLAKAREAFE--KALSIEPDFFPAAAnlaRID 509

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603   414 THEEDIDSAIDVFSQAIQYYqseqPGssiHLSLVREAANYKLKYGRKKEATSDLEQLWRQNTNDIHTLAQLISAYsLVDQ 493
Cdd:TIGR02917 510 IQEGNPDDAIQRFEKVLTID----PK---NLRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQYY-LGKG 581


                  ....*..
gi 79158603   494 DKAKALS 500
Cdd:TIGR02917 582 QLKKALA 588
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 20-139 1.94e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 38.63  E-value: 1.94e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603  20 QNGDFTRALKAVNKILHENKDDVTALRCKIVCLIQNGGFKEALNVINthtKSLTSD----MIGFEKAYCEYRLNRVENAL 95
Cdd:COG4783  16 LAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLH---EALELDpdepEARLNLGLALLKAGDYDEAL 92

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 79158603  96 ----KTIQGIPEQTDKLKELyGQVLYRLERYDECLAVYKDLIRNSQDE 139
Cdd:COG4783  93 alleKALKLDPEHPEAYLRL-ARAYRALGRPDEAIAALEKALELDPDD 139
PRK11788 PRK11788
tetratricopeptide repeat protein; Provisional
 308-431 3.52e-03

tetratricopeptide repeat protein; Provisional


Pssm-ID: 236983 [Multi-domain]  Cd Length: 389  Bit Score: 39.79  E-value: 3.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603  308 ALLAMYTNQADQCNKLLSSLQTQNPTHPRPVLIQvAQLC-REKQHSKAIELLQRFSDQHPESASGIKLTMAQLYLTQGHV 386
Cdd:PRK11788 187 AQQALARGDLDAARALLKKALAADPQCVRASILL-GDLAlAQGDYAAAIEALERVEEQDPEYLSEVLPKLMECYQALGDE 265

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 79158603  387 TKACDILKSIEEfkYKPGmISALITMYTH---EEDIDSAIDVFSQAIQ 431
Cdd:PRK11788 266 AEGLEFLRRALE--EYPG-ADLLLALAQLleeQEGPEAAQALLREQLR 310
TPR_12 pfam13424
Tetratricopeptide repeat;
191-255 6.63e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 35.83  E-value: 6.63e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 79158603   191 QAMKKLQKAEELCRKSLAEDSDMTEEDiDAELAVIHSQMAYVIQLQGRTEDALQLYSQVIKLKPS 255
Cdd:pfam13424  14 RRLGRYDEALELLEKALEIARRLLGPD-HPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 187-431 6.24e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 60.13  E-value: 6.24e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603 187 GELGQAMKKLQKAEELCRKSLAEDSDmtEEDIDAELAVIHSQmayviqlQGRTEDALQLYSQVIKLKPSDVGLLAvtanN 266
Cdd:COG2956  49 GNLYRRRGEYDRAIRIHQKLLERDPD--RAEALLELAQDYLK-------AGLLDRAEELLEKLLELDPDDAEALR----L 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603 267 IITINKDQNvfdskkkvKLTNAEGVEHKLAKKQLQAIEI--NKALLAMYTNQADQCNKLLSSLQTQNPTHPRPVLIQVAQ 344
Cdd:COG2956 116 LAEIYEQEG--------DWEKAIEVLERLLKLGPENAHAycELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAEL 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603 345 LCREKQHSKAIELLQRFSDQHPESASGIKLtMAQLYLTQGHVTKACDILKSIEEFKYKPGMISALITMYTHEEDIDSAID 424
Cdd:COG2956 188 YLEQGDYEEAIAALERALEQDPDYLPALPR-LAELYEKLGDPEEALELLRKALELDPSDDLLLALADLLERKEGLEAALA 266


                ....*..
gi 79158603 425 VFSQAIQ 431
Cdd:COG2956 267 LLERQLR 273
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 235-499 1.97e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 58.59  E-value: 1.97e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603 235 LQGRTEDALQLYSQVIKLKPSDVGLLAVTANniitinkdqnVFDSKKKVKltNAEGVEHKLAKKQLQAIEINKALLAMY- 313
Cdd:COG2956  20 LNGQPDKAIDLLEEALELDPETVEAHLALGN----------LYRRRGEYD--RAIRIHQKLLERDPDRAEALLELAQDYl 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603 314 -TNQADQCNKLLSSLQTQNPTHPRpVLIQVAQLC-REKQHSKAIELLQRFSDQHPESASgIKLTMAQLYLTQGHVTKACD 391
Cdd:COG2956  88 kAGLLDRAEELLEKLLELDPDDAE-ALRLLAEIYeQEGDWEKAIEVLERLLKLGPENAH-AYCELAELYLEQGDYDEAIE 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603 392 ILKSIeeFKYKPGMISALITM---YTHEEDIDSAIDVFSQAIQyyqsEQPGSSIHLSLVREAAnykLKYGRKKEATSDLE 468
Cdd:COG2956 166 ALEKA--LKLDPDCARALLLLaelYLEQGDYEEAIAALERALE----QDPDYLPALPRLAELY---EKLGDPEEALELLR 236

                       250       260       270
                ....*....|....*....|....*....|.
gi 79158603 469 QLWRQNTNDIHTLAQLISAYSLVDQDKAKAL 499
Cdd:COG2956 237 KALELDPSDDLLLALADLLERKEGLEAALAL 267
SRP_TPR_like pfam17004
Putative TPR-like repeat; This is a family of microsporidial sequences that are likely to fold ...
 46-151 1.85e-08

Putative TPR-like repeat; This is a family of microsporidial sequences that are likely to fold into a TPR-like structure. Many sequences are annotated as being signal recognition proteins.


Pssm-ID: 435703 [Multi-domain]  Cd Length: 109  Bit Score: 52.39  E-value: 1.85e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603    46 RCKIVCLIQNGGFKEALnvinthtkSLTSDMiGFEKAYCEYRLNRVENALKTIQGIpeQTDKLKELYGQVLYRLERYDEc 125
Cdd:pfam17004  18 RFKVIALIHLDKYKEAL--------KYAKKG-SFEKAYALYKLKKYKKALKILRKM--DSEGSRVLASQCLYFLGYYNK- 85

                          90       100
                  ....*....|....*....|....*.
gi 79158603   126 laVYKDLirnSQDEYEEERKTNLSAV 151
Cdd:pfam17004  86 --AYKIL---SECKRDDEIVVNLQAM 106
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 307-499 2.30e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 55.51  E-value: 2.30e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603 307 KALLAMYTNQADQCNKLLSSLQTQNPTHPrPVLIQVAQLCREK-QHSKAIELLQRFSDQHPESASgIKLTMAQLYLTQGH 385
Cdd:COG2956  14 KGLNYLLNGQPDKAIDLLEEALELDPETV-EAHLALGNLYRRRgEYDRAIRIHQKLLERDPDRAE-ALLELAQDYLKAGL 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603 386 VTKACDILKS-IEEFKYKPGMISALITMYTHEEDIDSAIDVFSQAI---------------QYYQSEQPGSSI------- 442
Cdd:COG2956  92 LDRAEELLEKlLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLklgpenahaycelaeLYLEQGDYDEAIealekal 171

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 79158603 443 -----HLSLVREAANYKLKYGRKKEATSDLEQLWRQNTNDIHTLAQLISAY-SLVDQDKAKAL 499
Cdd:COG2956 172 kldpdCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYeKLGDPEEALEL 234
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 21-500 6.10e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 52.39  E-value: 6.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603    21 NGDFTRALKAVNKILHENKDDVTALRCKIVCLIQNGGFKEALNVINTHTKsLTSDMIG--FEKAYCEYRLNRVENALKTI 98
Cdd:TIGR02917 172 ENRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIA-LRPNNIAvlLALATILIEAGEFEEAEKHA 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603    99 QGIPEQT-DKLKELYgqvlyrlerydeclavYKDLIRNSQDEYEEERkTNLSAVLAAQStwentppedlglpeSSYELCY 177
Cdd:TIGR02917 251 DALLKKApNSPLAHY----------------LKALVDFQKKNYEDAR-ETLQDALKSAP--------------EYLPALL 299

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603   178 NAACCLIGQGELGQAMKKLQKAEelcrkslaedsDMTEEDIDAELavihsqMAYVIQL-QGRTEDALQLYSQVIKLKPSD 256
Cdd:TIGR02917 300 LAGASEYQLGNLEQAYQYLNQIL-----------KYAPNSHQARR------LLASIQLrLGRVDEAIATLSPALGLDPDD 362

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603   257 VGLLAVtANNIITINKDqnvFDSKKKVkLTNAEGVEHKLAKKQLQaieinKALLAMYTNQADQCNKLLSSLQTQNPTHPR 336
Cdd:TIGR02917 363 PAALSL-LGEAYLALGD---FEKAAEY-LAKATELDPENAAARTQ-----LGISKLSQGDPSEAIADLETAAQLDPELGR 432

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603   337 PVLIQVAQLCREKQHSKAIELLQRFSDQHPESASGIKLtMAQLYLTQGHVTKACDILKsiEEFKYKPGMISALI---TMY 413
Cdd:TIGR02917 433 ADLLLILSYLRSGQFDKALAAAKKLEKKQPDNASLHNL-LGAIYLGKGDLAKAREAFE--KALSIEPDFFPAAAnlaRID 509

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603   414 THEEDIDSAIDVFSQAIQYYqseqPGssiHLSLVREAANYKLKYGRKKEATSDLEQLWRQNTNDIHTLAQLISAYsLVDQ 493
Cdd:TIGR02917 510 IQEGNPDDAIQRFEKVLTID----PK---NLRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQYY-LGKG 581


                  ....*..
gi 79158603   494 DKAKALS 500
Cdd:TIGR02917 582 QLKKALA 588
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 110-434 3.13e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 49.99  E-value: 3.13e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603 110 ELYGQVLYRLERYDECLAVYKDLIRNSQDEYEEERKTNLSAVLAAQSTWENTPPEDLGLPESSYELC-YNAACCLIGQGE 188
Cdd:COG3914   7 LALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAAlLLLAALLELAAL 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603 189 LGQAMKKLQKAEELCRKSLAedsdmteedIDAELAVIHSQMAYVIQLQGRTEDALQLYSQVIKLKPSDVGLLavtaNNII 268
Cdd:COG3914  87 LLQALGRYEEALALYRRALA---------LNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAY----LNLG 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603 269 TINKDQNVFDskkkvkltnaegvehklakkqlQAIEI-NKALlamytnqadqcnkllsslqTQNPTHPRpVLIQVAQLCR 347
Cdd:COG3914 154 EALRRLGRLE----------------------EAIAAlRRAL-------------------ELDPDNAE-ALNNLGNALQ 191

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603 348 E-KQHSKAIELLQRFSDQHPESASgIKLTMAQLYLTQGHVTKACDILKSIEEFKYKPGMISALITMYTHEediDSAIDVF 426
Cdd:COG3914 192 DlGRLEEAIAAYRRALELDPDNAD-AHSNLLFALRQACDWEVYDRFEELLAALARGPSELSPFALLYLPD---DDPAELL 267


                ....*...
gi 79158603 427 SQAIQYYQ 434
Cdd:COG3914 268 ALARAWAQ 275
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 20-262 9.21e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.42  E-value: 9.21e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603  20 QNGDFTRALKAVNKILHENKDDVTALRCKIVCLIQNGGFKEAlnvINTHTKSLTSDMiGFEKAYCE----Y----RLNRV 91
Cdd:COG2956  20 LNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRA---IRIHQKLLERDP-DRAEALLElaqdYlkagLLDRA 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603  92 ENALKTIQGIPEQTDKLKELYGQVLYRLERYDECLAVYKDLIRNSQDEyeeerkTNLSAVLAAQSTWENTPPEDLGLPES 171
Cdd:COG2956  96 EELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPEN------AHAYCELAELYLEQGDYDEAIEALEK 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603 172 SYELCYNAACCLIGQGELGQAMKKLQKAEELCRKSLAedsdmteedIDAELAVIHSQMAYVIQLQGRTEDALQLYSQVIK 251
Cdd:COG2956 170 ALKLDPDCARALLLLAELYLEQGDYEEAIAALERALE---------QDPDYLPALPRLAELYEKLGDPEEALELLRKALE 240

                       250
                ....*....|.
gi 79158603 252 LKPSDVGLLAV 262
Cdd:COG2956 241 LDPSDDLLLAL 251
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 308-503 2.74e-04

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 43.36  E-value: 2.74e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603 308 ALLAMYTNQADQCNKLLSSLQTQNPTHPRPVLIQVAQLC-REKQHSKAIELLQRFSDQHPESASGIKLtMAQLYLTQGHV 386
Cdd:COG3071  57 ARAAQALGDYERRDEYLAQALELAPEAELAVLLTRAELLlDQGQAEQALATLEALRAGAPRHPQVLRL-LLQAYRQLGDW 135

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603 387 TKACDILKSIEEFK-YKPGMISALITMyTHEEDIDSAIDVFSQAIQYYQSeQPGSSIHL-SLVREAANYKLKYGRKKEAT 464
Cdd:COG3071 136 EELLELLPALRKHKaLSAEEAQALERR-AYLGLLRQAARDAEALKALWKA-LPRAERRDpELAAAYARALIALGDHDEAE 213

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 79158603 465 SDLEQLWRQNTNDihtlaQLISAYSLVDQDKAKALSKHL 503
Cdd:COG3071 214 RLLREALKRQWDP-----RLVRLYGRLQGGDPAKQLKRA 247
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
174-260 3.15e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 42.69  E-value: 3.15e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603 174 ELCYNAACCLIGQGELGQAMKKLQKAEELCRKSLAedsdmteedIDAELAVIHSQMAYVIQLQGRTEDALQLYSQVIKLK 253
Cdd:COG0457   2 ELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALE---------LDPDDAEALYNLGLAYLRLGRYEEALADYEQALELD 72


                ....*..
gi 79158603 254 PSDVGLL 260
Cdd:COG0457  73 PDDAEAL 79
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 191-470 4.29e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.15  E-value: 4.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603   191 QAMKKLQKAEELCRKSLAEDSDMTEEDIdaelavihsQMAYVIQLQGRTEDALQLYSQVIKLKPSDVGLLAVTANNIITI 270
Cdd:TIGR02917 646 AVMKNYAKAITSLKRALELKPDNTEAQI---------GLAQLLLAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQ 716

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603   271 NKDQNVFDSKKKVkltnaegveHKLAKKQLQAIEINKALLAmyTNQADQCNKLLSSLQTQNPTHPRPVLIQVAQLCREKQ 350
Cdd:TIGR02917 717 KDYPAAIQAYRKA---------LKRAPSSQNAIKLHRALLA--SGNTAEAVKTLEAWLKTHPNDAVLRTALAELYLAQKD 785

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603   351 HSKAIELLQRFSDQHPESASGIKlTMAQLYLTQ------GHVTKAcdilksieeFKYKPGMISALIT---MYTHEEDIDS 421
Cdd:TIGR02917 786 YDKAIKHYQTVVKKAPDNAVVLN-NLAWLYLELkdpralEYAERA---------LKLAPNIPAILDTlgwLLVEKGEADR 855

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 79158603   422 AIDVFSQAIQyYQSEQPGSSIHLSLVREAAnyklkyGRKKEATSDLEQL 470
Cdd:TIGR02917 856 ALPLLRKAVN-IAPEAAAIRYHLALALLAT------GRKAEARKELDKL 897
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
191-256 1.37e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 40.76  E-value: 1.37e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 79158603 191 QAMKKLQKAEELCRKSLAedsdmteedIDAELAVIHSQMAYVIQLQGRTEDALQLYSQVIKLKPSD 256
Cdd:COG0457  53 LRLGRYEEALADYEQALE---------LDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDD 109
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 20-139 1.94e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 38.63  E-value: 1.94e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603  20 QNGDFTRALKAVNKILHENKDDVTALRCKIVCLIQNGGFKEALNVINthtKSLTSD----MIGFEKAYCEYRLNRVENAL 95
Cdd:COG4783  16 LAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLH---EALELDpdepEARLNLGLALLKAGDYDEAL 92

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 79158603  96 ----KTIQGIPEQTDKLKELyGQVLYRLERYDECLAVYKDLIRNSQDE 139
Cdd:COG4783  93 alleKALKLDPEHPEAYLRL-ARAYRALGRPDEAIAALEKALELDPDD 139
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 343-477 2.32e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 38.63  E-value: 2.32e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603 343 AQLCREKQHSKAIELLQRFSDQHPESASgIKLTMAQLYLTQGHVTKACDIL-KSIEEFKYKPGMISALITMYTHEEDIDS 421
Cdd:COG4783  12 QALLLAGDYDEAEALLEKALELDPDNPE-AFALLGEILLQLGDLDEAIVLLhEALELDPDEPEARLNLGLALLKAGDYDE 90

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 79158603 422 AIDVFSQAIQyYQSEQPGSSIHLSLVREAAnyklkyGRKKEATSDLEQLWRQNTND 477
Cdd:COG4783  91 ALALLEKALK-LDPEHPEAYLRLARAYRAL------GRPDEAIAALEKALELDPDD 139
PRK11788 PRK11788
tetratricopeptide repeat protein; Provisional
 308-431 3.52e-03

tetratricopeptide repeat protein; Provisional


Pssm-ID: 236983 [Multi-domain]  Cd Length: 389  Bit Score: 39.79  E-value: 3.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603  308 ALLAMYTNQADQCNKLLSSLQTQNPTHPRPVLIQvAQLC-REKQHSKAIELLQRFSDQHPESASGIKLTMAQLYLTQGHV 386
Cdd:PRK11788 187 AQQALARGDLDAARALLKKALAADPQCVRASILL-GDLAlAQGDYAAAIEALERVEEQDPEYLSEVLPKLMECYQALGDE 265

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 79158603  387 TKACDILKSIEEfkYKPGmISALITMYTH---EEDIDSAIDVFSQAIQ 431
Cdd:PRK11788 266 AEGLEFLRRALE--EYPG-ADLLLALAQLleeQEGPEAAQALLREQLR 310
TPR_12 pfam13424
Tetratricopeptide repeat;
191-255 6.63e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 35.83  E-value: 6.63e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 79158603   191 QAMKKLQKAEELCRKSLAEDSDMTEEDiDAELAVIHSQMAYVIQLQGRTEDALQLYSQVIKLKPS 255
Cdd:pfam13424  14 RRLGRYDEALELLEKALEIARRLLGPD-HPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
ANAPC3 pfam12895
Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of ...
 79-131 6.64e-03

Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. The protein members of this family contain TPR repeats just as those of Apc7 do, and it appears that these TPR units bind the C-termini of the APC co-activators CDH1 and CDC20.


Pssm-ID: 463743 [Multi-domain]  Cd Length: 82  Bit Score: 35.69  E-value: 6.64e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 79158603    79 FEKAYCEYRLNRVENALKTIQ--GIPEQTDKLKELYGQVLYRLERYDECLAVYKD 131
Cdd:pfam12895  27 YLLAQCLFLNGQYKRAYELLRkaKLNGSSLGCRYLFAQCLLKLKKYDEALDALGK 81
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 187-398 6.75e-03

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 39.20  E-value: 6.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603   187 GELGQAMKKLQKAEELcrkslaedsdmteediDAELAVIHSQMAYVIQLQGRTEDALQLYSQVIKLKPS--DVgllavtA 264
Cdd:TIGR00990 413 GEFAQAGKDYQKSIDL----------------DPDFIFSHIQLGVTQYKEGSIASSMATFRRCKKNFPEapDV------Y 470

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79158603   265 NNIITINKDQNVFDskkkvkltnaegvehKLAKKQLQAIEINKALLAMYTNQADQCNKLLSSLQTQnpthprpvliqvaq 344
Cdd:TIGR00990 471 NYYGELLLDQNKFD---------------EAIEKFDTAIELEKETKPMYMNVLPLINKALALFQWK-------------- 521

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 79158603   345 lcreKQHSKAIELLQRFSDQHPESASGiKLTMAQLYLTQGHVTKAcdiLKSIEE 398
Cdd:TIGR00990 522 ----QDFIEAENLCEKALIIDPECDIA-VATMAQLLLQQGDVDEA---LKLFER 567
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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