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Conserved domains on  [gi|56971383|gb|AAH88343|]
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Ncoa3 protein, partial [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF1518 pfam07469
Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually ...
 155-212 1.71e-06

Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually found tandemly repeated in the nuclear receptor coactivator family (NCOA1/2/3, also known as the SRC/p160 nuclear receptor coactivator family, which are ligand-dependent transcription factors.


:

Pssm-ID: 462174  Cd Length: 58  Bit Score: 44.37  E-value: 1.71e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 56971383   155 SMDGVLAGSAMPQAPPQQFPYATNYGMGQPPEPAFGRGSSPPSAMMSSRMGPSQNAMV 212
Cdd:pfam07469   1 GMGGQFGGPRNPQAQPQQFPYPPNYGMSQQPDPAFTSALSPQSPMMSPRMGPSQSPMM 58
PABP-1234 super family cl31127
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 118-286 5.92e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


The actual alignment was detected with superfamily member TIGR01628:

Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 37.86  E-value: 5.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56971383   118 QKRELMNHHLQQQRMammmsQPQPQAFSPPPNVTASPSMDGVLAGSAMP--QAPPQQFPYATNYGMGQPPEPAFGRGSSP 195
Cdd:TIGR01628 362 QRKEQRRAHLQDQFM-----QLQPRMRQLPMGSPMGGAMGQPPYYGQGPqqQFNGQPLGWPRMSMMPTPMGPGGPLRPNG 436

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56971383   196 PSAMMSSRMGPS--QNAMVQHPQTAPMYQSSemkgwpsgnlARNGSFPQQQFAPQANPaaynmvhmnssgSHLGQMTMTP 273
Cdd:TIGR01628 437 LAPMNAVRAPSRnaQNAAQKPPMQPVMYPPN----------YQSLPLSQDLPQPQSTA------------SQGGQNKKLA 494

                         170
                  ....*....|...
gi 56971383   274 MPMSGMPMGpDQK 286
Cdd:TIGR01628 495 QVLASATPQ-MQK 506
 
Name Accession Description Interval E-value
DUF1518 pfam07469
Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually ...
 155-212 1.71e-06

Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually found tandemly repeated in the nuclear receptor coactivator family (NCOA1/2/3, also known as the SRC/p160 nuclear receptor coactivator family, which are ligand-dependent transcription factors.


Pssm-ID: 462174  Cd Length: 58  Bit Score: 44.37  E-value: 1.71e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 56971383   155 SMDGVLAGSAMPQAPPQQFPYATNYGMGQPPEPAFGRGSSPPSAMMSSRMGPSQNAMV 212
Cdd:pfam07469   1 GMGGQFGGPRNPQAQPQQFPYPPNYGMSQQPDPAFTSALSPQSPMMSPRMGPSQSPMM 58
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 118-286 5.92e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 37.86  E-value: 5.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56971383   118 QKRELMNHHLQQQRMammmsQPQPQAFSPPPNVTASPSMDGVLAGSAMP--QAPPQQFPYATNYGMGQPPEPAFGRGSSP 195
Cdd:TIGR01628 362 QRKEQRRAHLQDQFM-----QLQPRMRQLPMGSPMGGAMGQPPYYGQGPqqQFNGQPLGWPRMSMMPTPMGPGGPLRPNG 436

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56971383   196 PSAMMSSRMGPS--QNAMVQHPQTAPMYQSSemkgwpsgnlARNGSFPQQQFAPQANPaaynmvhmnssgSHLGQMTMTP 273
Cdd:TIGR01628 437 LAPMNAVRAPSRnaQNAAQKPPMQPVMYPPN----------YQSLPLSQDLPQPQSTA------------SQGGQNKKLA 494

                         170
                  ....*....|...
gi 56971383   274 MPMSGMPMGpDQK 286
Cdd:TIGR01628 495 QVLASATPQ-MQK 506
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 133-280 6.04e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 38.09  E-value: 6.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56971383   133 AMMMSQPQPQAFSPPPNVTASPSMDGVLAGSAMPQAPPQQFPYATNYGMGQPPEPAFGRGS--------SPPSAMMSSRM 204
Cdd:pfam09770 201 AAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHpvtilqrpQSPQPDPAQPS 280

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 56971383   205 GPSQNAMVQHPQTAPMYQSSEMKGWPSGNLARNGSFPQQQFAPQANPAAYNMVHMNSSGSHLGQMTMTPMPMSGMP 280
Cdd:pfam09770 281 IQPQAQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQAPIITHPQQLAQLS 356
 
Name Accession Description Interval E-value
DUF1518 pfam07469
Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually ...
 155-212 1.71e-06

Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually found tandemly repeated in the nuclear receptor coactivator family (NCOA1/2/3, also known as the SRC/p160 nuclear receptor coactivator family, which are ligand-dependent transcription factors.


Pssm-ID: 462174  Cd Length: 58  Bit Score: 44.37  E-value: 1.71e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 56971383   155 SMDGVLAGSAMPQAPPQQFPYATNYGMGQPPEPAFGRGSSPPSAMMSSRMGPSQNAMV 212
Cdd:pfam07469   1 GMGGQFGGPRNPQAQPQQFPYPPNYGMSQQPDPAFTSALSPQSPMMSPRMGPSQSPMM 58
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 118-286 5.92e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 37.86  E-value: 5.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56971383   118 QKRELMNHHLQQQRMammmsQPQPQAFSPPPNVTASPSMDGVLAGSAMP--QAPPQQFPYATNYGMGQPPEPAFGRGSSP 195
Cdd:TIGR01628 362 QRKEQRRAHLQDQFM-----QLQPRMRQLPMGSPMGGAMGQPPYYGQGPqqQFNGQPLGWPRMSMMPTPMGPGGPLRPNG 436

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56971383   196 PSAMMSSRMGPS--QNAMVQHPQTAPMYQSSemkgwpsgnlARNGSFPQQQFAPQANPaaynmvhmnssgSHLGQMTMTP 273
Cdd:TIGR01628 437 LAPMNAVRAPSRnaQNAAQKPPMQPVMYPPN----------YQSLPLSQDLPQPQSTA------------SQGGQNKKLA 494

                         170
                  ....*....|...
gi 56971383   274 MPMSGMPMGpDQK 286
Cdd:TIGR01628 495 QVLASATPQ-MQK 506
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 133-280 6.04e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 38.09  E-value: 6.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56971383   133 AMMMSQPQPQAFSPPPNVTASPSMDGVLAGSAMPQAPPQQFPYATNYGMGQPPEPAFGRGS--------SPPSAMMSSRM 204
Cdd:pfam09770 201 AAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHpvtilqrpQSPQPDPAQPS 280

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 56971383   205 GPSQNAMVQHPQTAPMYQSSEMKGWPSGNLARNGSFPQQQFAPQANPAAYNMVHMNSSGSHLGQMTMTPMPMSGMP 280
Cdd:pfam09770 281 IQPQAQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQAPIITHPQQLAQLS 356
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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