Chemokine (C-C motif) ligand 22 [Rattus norvegicus]
Protein Classification
C-C motif chemokine( domain architecture ID 10084499)
C-C motif chemokine recruits and activates leukocytes, and plays a major role in both immune response and inflammation-related diseases
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| Chemokine_CC | cd00272 | Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ... |
36-91 | 7.56e-19 | ||
Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. 2HCC) contain an additional disulfide bond which is thought to compensate for the highly conserved Trp missing in these; chemotatic for monocytes, macrophages, eosinophils, basophils, and T cells, but not neutrophils; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates and a few viruses; a subgroup of CC, identified by an N-terminal DCCL motif (Exodus-1, Exodus-2, and Exodus-3), has been shown to inhibit specific types of human cancer cell growth in a mouse model. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CXC (cd00273), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups, and Chemokine_CC_DCCL for the DCCL subgroup of this CD. : Pssm-ID: 238170 Cd Length: 57 Bit Score: 72.66 E-value: 7.56e-19
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| Name | Accession | Description | Interval | E-value | ||
| Chemokine_CC | cd00272 | Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ... |
36-91 | 7.56e-19 | ||
Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. 2HCC) contain an additional disulfide bond which is thought to compensate for the highly conserved Trp missing in these; chemotatic for monocytes, macrophages, eosinophils, basophils, and T cells, but not neutrophils; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates and a few viruses; a subgroup of CC, identified by an N-terminal DCCL motif (Exodus-1, Exodus-2, and Exodus-3), has been shown to inhibit specific types of human cancer cell growth in a mouse model. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CXC (cd00273), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups, and Chemokine_CC_DCCL for the DCCL subgroup of this CD. Pssm-ID: 238170 Cd Length: 57 Bit Score: 72.66 E-value: 7.56e-19
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| SCY | smart00199 | Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved ... |
36-91 | 4.85e-17 | ||
Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response. Pssm-ID: 197570 Cd Length: 59 Bit Score: 68.04 E-value: 4.85e-17
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| IL8 | pfam00048 | Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted ... |
34-91 | 5.23e-17 | ||
Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds. Pssm-ID: 459650 Cd Length: 60 Bit Score: 68.06 E-value: 5.23e-17
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| Name | Accession | Description | Interval | E-value | ||
| Chemokine_CC | cd00272 | Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ... |
36-91 | 7.56e-19 | ||
Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. 2HCC) contain an additional disulfide bond which is thought to compensate for the highly conserved Trp missing in these; chemotatic for monocytes, macrophages, eosinophils, basophils, and T cells, but not neutrophils; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates and a few viruses; a subgroup of CC, identified by an N-terminal DCCL motif (Exodus-1, Exodus-2, and Exodus-3), has been shown to inhibit specific types of human cancer cell growth in a mouse model. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CXC (cd00273), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups, and Chemokine_CC_DCCL for the DCCL subgroup of this CD. Pssm-ID: 238170 Cd Length: 57 Bit Score: 72.66 E-value: 7.56e-19
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| SCY | smart00199 | Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved ... |
36-91 | 4.85e-17 | ||
Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response. Pssm-ID: 197570 Cd Length: 59 Bit Score: 68.04 E-value: 4.85e-17
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| IL8 | pfam00048 | Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted ... |
34-91 | 5.23e-17 | ||
Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds. Pssm-ID: 459650 Cd Length: 60 Bit Score: 68.06 E-value: 5.23e-17
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| Chemokine | cd00169 | Chemokine: small cytokines, including a number of secreted growth factors and interferons ... |
36-91 | 1.18e-11 | ||
Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided into 4 subfamilies based on the arrangement of the two N-terminal cysteines; some members can bind multiple receptors and many chemokine receptors can bind more than one chemokine; this redundancy allows precise control in stimulating the immune system and in contributing to the homeostasis of a cell; when expressed inappropriately, chemokines play a role in autoimmune diseases, vascular irregularities, graft rejection, neoplasia, and allergies; exist as monomers, dimers and multimers, but are believed to function as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine_CXC (cd00273), Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for chemokine subgroups. Pssm-ID: 238098 Cd Length: 59 Bit Score: 54.65 E-value: 1.18e-11
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| Chemokine_CC_DCCL | cd01119 | Chemokine_CC_DCCL: subgroup of the Chemokine_CC subgroup based on the presence of a DCCL ... |
36-91 | 1.17e-10 | ||
Chemokine_CC_DCCL: subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by blocking progression through the cell cycle; DCCL subgroup contains Exodus-1 (also known as CCL20, MIP-3alpha, LARC, ST38 (mouse)), Exodus-2 (also known as CCL21, SLC, 6-Ckine, TCA4, CKbeta9), and Exodus-3 (also known as CCL-19, ELC, MIP-3beta, CKbeta11). Exodus-3 was shown to inhibit the growth of human breast cancer cells in vivo in a mouse model; Exodus-1, -2, and -3 were all shown to significantly inhibit chronic myelogenous leukemia progenitor cell proliferation; Exodus-2 and -3 show potent immunotherapeutic activity toward solid tumors; chemotatic for T cells, B cells, dendritic cells, macrophage progenitor cells, and NK cells; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates. See CDs: Chemokine_CC (cd00272) for the entire CC subgroup, Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CXC (cd00273), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups. Pssm-ID: 238539 Cd Length: 61 Bit Score: 52.02 E-value: 1.17e-10
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| Chemokine_CXC | cd00273 | Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ... |
37-91 | 2.05e-05 | ||
Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members contain an RCxC motif which may be a general requirement for binding to CXC chemokine receptors; those with the ELR motif are chemotatic for neutrophils and have been shown to be angiogenic, while those without the motif act on T and B cells, and are typically angiostatic; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups. Pssm-ID: 238171 Cd Length: 64 Bit Score: 38.78 E-value: 2.05e-05
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| Chemokine_CX3C | cd00274 | Chemokine_CX3C: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ... |
34-91 | 1.77e-04 | ||
Chemokine_CX3C: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteines; differ structurally from the other subgroups in that they are attached to a membrane-spanning domain via a mucin-like stalk and can be proteolytically cleaved to a freely diffusible form; chemotatic for T cells, monocytes, and natural killer cells; function as monomers and are found only in vertebrates and a few viruses; currently only fractalkine (sometimes called neurotactin) has been identified as a member of this subfamily; the primary source of fractalkine is neurons, and they exhibit cell adhesion and chemoattractive properties in the central nervous system. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CXC (cd00273), Chemokine_CC (cd00272), and Chemokine_C (cd00271) for the additional chemokine subgroups. Pssm-ID: 238172 Cd Length: 76 Bit Score: 36.58 E-value: 1.77e-04
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