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Conserved domains on  [gi|51330093|gb|AAH80268|]
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Zgc:91996 [Danio rerio]

Protein Classification

BRCT domain-containing protein( domain architecture ID 13667286)

BRCT (BRCA1 C-terminus) domain-containing protein may interact with DNA, and participate in DNA-damage checkpoint or DNA-repair pathways

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
XRCC1_N pfam01834
XRCC1 N terminal domain;
1-148 5.15e-90

XRCC1 N terminal domain;


:

Pssm-ID: 460356  Cd Length: 148  Bit Score: 274.89  E-value: 5.15e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51330093     1 MPELKLKHVVSCSSEDNTHKADNLLSSDTYRKWKAARPGEKQVSVILQLEKEEQIHSIDIGNEGSAFIEVLVGHSTSVKD 80
Cdd:pfam01834   1 MPPIKLKHVVSCSSEDPVHPAENLLKSDTYRKWKCAKPGEKQASVELQLERASQITSIDIGNEGSAFVEVLVGRSSWPDD 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 51330093    81 QDFEVLLVTSSFMSPTESRNGTNTNRVRFFGPGQLVKAQSQEKWDRVKIVCSQPYSKTIAYGISFIKL 148
Cdd:pfam01834  81 QDFEVLLVTSSFMTPSESKNGTNRNRVRMFGKDKLNSSAAEEKWDRVKIVCTQPFNKTVQYGLSFIKF 148
BRCT_XRCC1_rpt2 cd17707
Second (C-terminal) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and ...
 522-615 9.56e-57

Second (C-terminal) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar proteins; XRCC1 is a DNA repair protein that corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. It forms homodimers and interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB), DNA ligase III (LIG3), APTX, APLF, and APEX1. XRCC1 contains an N-terminal XRCC1-specific domain and two BRCT domains. This model corresponds to the second BRCT domain.


:

Pssm-ID: 349340  Cd Length: 94  Bit Score: 185.93  E-value: 9.56e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51330093 522 ELPDFLKGKRFYLYGKFPDNQKRLLLRYIIAFNGAVEDYMSEKVQFVITSEGWDDSFEDALMENGSLSFVKPTWIFAIND 601
Cdd:cd17707   1 ELPDFFSGKHFFLYGDFPADERRLLKRYITAFNGEVEDYMSDKVTFVVTNQEWDDNFDEALAENPSLAFVRPRWIYACHE 80

                        90
                ....*....|....
gi 51330093 602 RQKMLPYQPYTVVP 615
Cdd:cd17707  81 KQKLLPCQPYLVVP 94
BRCT_XRCC1_rpt1 cd17725
First (central) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar ...
 324-403 1.17e-53

First (central) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar proteins; XRCC1 is a DNA repair protein that corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. It forms homodimers and interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB), DNA ligase III (LIG3), APTX, APLF, and APEX1. XRCC1 contains an N-terminal XRCC1-specific domain and two BRCT domains. This family corresponds to the first one.


:

Pssm-ID: 349357 [Multi-domain]  Cd Length: 80  Bit Score: 177.47  E-value: 1.17e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51330093 324 GVVFVLSGFQNPFRADLRDKALALGARYRPDWTPDATHLICAFANTPKYSQVKAAGGIIVRKEWVMDCHKNKQKISCKRY 403
Cdd:cd17725   1 GVVFVLSGFQNPFRGELRDKALEMGAKYRPDWTADCTHLICAFANTPKYKQVKGAGGIIVSKEWILDCYKKKKRLPWKRY 80
 
Name Accession Description Interval E-value
XRCC1_N pfam01834
XRCC1 N terminal domain;
1-148 5.15e-90

XRCC1 N terminal domain;


Pssm-ID: 460356  Cd Length: 148  Bit Score: 274.89  E-value: 5.15e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51330093     1 MPELKLKHVVSCSSEDNTHKADNLLSSDTYRKWKAARPGEKQVSVILQLEKEEQIHSIDIGNEGSAFIEVLVGHSTSVKD 80
Cdd:pfam01834   1 MPPIKLKHVVSCSSEDPVHPAENLLKSDTYRKWKCAKPGEKQASVELQLERASQITSIDIGNEGSAFVEVLVGRSSWPDD 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 51330093    81 QDFEVLLVTSSFMSPTESRNGTNTNRVRFFGPGQLVKAQSQEKWDRVKIVCSQPYSKTIAYGISFIKL 148
Cdd:pfam01834  81 QDFEVLLVTSSFMTPSESKNGTNRNRVRMFGKDKLNSSAAEEKWDRVKIVCTQPFNKTVQYGLSFIKF 148
BRCT_XRCC1_rpt2 cd17707
Second (C-terminal) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and ...
 522-615 9.56e-57

Second (C-terminal) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar proteins; XRCC1 is a DNA repair protein that corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. It forms homodimers and interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB), DNA ligase III (LIG3), APTX, APLF, and APEX1. XRCC1 contains an N-terminal XRCC1-specific domain and two BRCT domains. This model corresponds to the second BRCT domain.


Pssm-ID: 349340  Cd Length: 94  Bit Score: 185.93  E-value: 9.56e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51330093 522 ELPDFLKGKRFYLYGKFPDNQKRLLLRYIIAFNGAVEDYMSEKVQFVITSEGWDDSFEDALMENGSLSFVKPTWIFAIND 601
Cdd:cd17707   1 ELPDFFSGKHFFLYGDFPADERRLLKRYITAFNGEVEDYMSDKVTFVVTNQEWDDNFDEALAENPSLAFVRPRWIYACHE 80

                        90
                ....*....|....
gi 51330093 602 RQKMLPYQPYTVVP 615
Cdd:cd17707  81 KQKLLPCQPYLVVP 94
BRCT_XRCC1_rpt1 cd17725
First (central) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar ...
 324-403 1.17e-53

First (central) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar proteins; XRCC1 is a DNA repair protein that corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. It forms homodimers and interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB), DNA ligase III (LIG3), APTX, APLF, and APEX1. XRCC1 contains an N-terminal XRCC1-specific domain and two BRCT domains. This family corresponds to the first one.


Pssm-ID: 349357 [Multi-domain]  Cd Length: 80  Bit Score: 177.47  E-value: 1.17e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51330093 324 GVVFVLSGFQNPFRADLRDKALALGARYRPDWTPDATHLICAFANTPKYSQVKAAGGIIVRKEWVMDCHKNKQKISCKRY 403
Cdd:cd17725   1 GVVFVLSGFQNPFRGELRDKALEMGAKYRPDWTADCTHLICAFANTPKYKQVKGAGGIIVSKEWILDCYKKKKRLPWKRY 80
BRCT_2 pfam16589
BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found ...
 523-611 1.20e-14

BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found on many RAP1 proteins, usually at the very N-terminus. The function in human at least of a BRCT is to contribute to the heterogeneity of the telomere DNA length, but that may not be its general function, which remains unknown.


Pssm-ID: 465186 [Multi-domain]  Cd Length: 84  Bit Score: 69.32  E-value: 1.20e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51330093   523 LPDFLKGKRFYLYGkFPDNQKRLLLRYIIAFNGAVEDYMSEKVQFVITSEGWDDSfedaLMENGSLSFVKPTWIFAINDR 602
Cdd:pfam16589   1 LPNLFEPLRFYINA-IPSPSRSKLKRLIEANGGTVVDNINPAVYIVIAPYNKTDK----LAENTKLGVVSPQWIFDCVKK 75


                  ....*....
gi 51330093   603 QKMLPYQPY 611
Cdd:pfam16589  76 GKLLPLENY 84
BRCT pfam00533
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ...
 317-391 1.49e-14

BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.


Pssm-ID: 425736 [Multi-domain]  Cd Length: 75  Bit Score: 68.86  E-value: 1.49e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 51330093   317 PFNRILEGVVFVLSGFQNPFRADLRDKALALGARYRPDWTPDATHLICAfANTPKYSQVKAAGGIIVRKEWVMDC 391
Cdd:pfam00533   1 PKEKLFSGKTFVITGLDGLERDELKELIEKLGGKVTDSLSKKTTHVIVE-ARTKKYLKAKELGIPIVTEEWLLDC 74
BRCT smart00292
breast cancer carboxy-terminal domain;
321-391 4.84e-10

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 56.23  E-value: 4.84e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 51330093    321 ILEGVVFVLSG-FQNPFRADLRDKALALGARYRPDWT-PDATHLICAFANTPKYS--QVKAAGGIIVRKEWVMDC 391
Cdd:smart00292   3 LFKGKTFYITGsFDKEERDELKELIEALGGKVTSSLSsKTTTHVIVGSPEGGKLEllKAIALGIPIVKEEWLLDC 77
BRCT smart00292
breast cancer carboxy-terminal domain;
524-598 1.25e-07

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 49.30  E-value: 1.25e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 51330093    524 PDFLKGKRFYLYGKFPDNQKRLLLRYIIAFNGAVEDYMSEK-VQFVITSEGWDDSFEDALMENGSLSFVKPTWIFA 598
Cdd:smart00292   1 PKLFKGKTFYITGSFDKEERDELKELIEALGGKVTSSLSSKtTTHVIVGSPEGGKLELLKAIALGIPIVKEEWLLD 76
 
Name Accession Description Interval E-value
XRCC1_N pfam01834
XRCC1 N terminal domain;
1-148 5.15e-90

XRCC1 N terminal domain;


Pssm-ID: 460356  Cd Length: 148  Bit Score: 274.89  E-value: 5.15e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51330093     1 MPELKLKHVVSCSSEDNTHKADNLLSSDTYRKWKAARPGEKQVSVILQLEKEEQIHSIDIGNEGSAFIEVLVGHSTSVKD 80
Cdd:pfam01834   1 MPPIKLKHVVSCSSEDPVHPAENLLKSDTYRKWKCAKPGEKQASVELQLERASQITSIDIGNEGSAFVEVLVGRSSWPDD 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 51330093    81 QDFEVLLVTSSFMSPTESRNGTNTNRVRFFGPGQLVKAQSQEKWDRVKIVCSQPYSKTIAYGISFIKL 148
Cdd:pfam01834  81 QDFEVLLVTSSFMTPSESKNGTNRNRVRMFGKDKLNSSAAEEKWDRVKIVCTQPFNKTVQYGLSFIKF 148
BRCT_XRCC1_rpt2 cd17707
Second (C-terminal) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and ...
 522-615 9.56e-57

Second (C-terminal) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar proteins; XRCC1 is a DNA repair protein that corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. It forms homodimers and interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB), DNA ligase III (LIG3), APTX, APLF, and APEX1. XRCC1 contains an N-terminal XRCC1-specific domain and two BRCT domains. This model corresponds to the second BRCT domain.


Pssm-ID: 349340  Cd Length: 94  Bit Score: 185.93  E-value: 9.56e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51330093 522 ELPDFLKGKRFYLYGKFPDNQKRLLLRYIIAFNGAVEDYMSEKVQFVITSEGWDDSFEDALMENGSLSFVKPTWIFAIND 601
Cdd:cd17707   1 ELPDFFSGKHFFLYGDFPADERRLLKRYITAFNGEVEDYMSDKVTFVVTNQEWDDNFDEALAENPSLAFVRPRWIYACHE 80

                        90
                ....*....|....
gi 51330093 602 RQKMLPYQPYTVVP 615
Cdd:cd17707  81 KQKLLPCQPYLVVP 94
BRCT_XRCC1_rpt1 cd17725
First (central) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar ...
 324-403 1.17e-53

First (central) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar proteins; XRCC1 is a DNA repair protein that corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. It forms homodimers and interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB), DNA ligase III (LIG3), APTX, APLF, and APEX1. XRCC1 contains an N-terminal XRCC1-specific domain and two BRCT domains. This family corresponds to the first one.


Pssm-ID: 349357 [Multi-domain]  Cd Length: 80  Bit Score: 177.47  E-value: 1.17e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51330093 324 GVVFVLSGFQNPFRADLRDKALALGARYRPDWTPDATHLICAFANTPKYSQVKAAGGIIVRKEWVMDCHKNKQKISCKRY 403
Cdd:cd17725   1 GVVFVLSGFQNPFRGELRDKALEMGAKYRPDWTADCTHLICAFANTPKYKQVKGAGGIIVSKEWILDCYKKKKRLPWKRY 80
BRCT cd00027
C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The ...
 325-391 6.17e-15

C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The BRCT (BRCA1 C-terminus) domain is found within many DNA damage repair and cell cycle checkpoint proteins. BRCT domains interact with each other forming homo/hetero BRCT multimers, but are also involved in BRCT-non-BRCT interactions and interactions within DNA strand breaks. BRCT tandem repeats bind to phosphopeptides; it has been shown that the repeats in human BRCA1 bind specifically to pS-X-X-F motifs, mediating the interaction between BRCA1 and the DNA helicase BACH1, or BRCA1 and CtIP, a transcriptional corepressor. It is assumed that BRCT repeats play similar roles in many signaling pathways associated with the response to DNA damage.


Pssm-ID: 349339 [Multi-domain]  Cd Length: 68  Bit Score: 69.70  E-value: 6.17e-15
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 51330093 325 VVFVLSGFQNPFRADLRDKALALGARYRPDWTPDATHLICAFANTPKYSQVKAAGGI-IVRKEWVMDC 391
Cdd:cd00027   1 LVICFSGLDDEEREELKKLIEALGGKVSESLSSKVTHLIAKSPSGEKYYLAALAWGIpIVSPEWLLDC 68
BRCT_2 pfam16589
BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found ...
 523-611 1.20e-14

BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found on many RAP1 proteins, usually at the very N-terminus. The function in human at least of a BRCT is to contribute to the heterogeneity of the telomere DNA length, but that may not be its general function, which remains unknown.


Pssm-ID: 465186 [Multi-domain]  Cd Length: 84  Bit Score: 69.32  E-value: 1.20e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51330093   523 LPDFLKGKRFYLYGkFPDNQKRLLLRYIIAFNGAVEDYMSEKVQFVITSEGWDDSfedaLMENGSLSFVKPTWIFAINDR 602
Cdd:pfam16589   1 LPNLFEPLRFYINA-IPSPSRSKLKRLIEANGGTVVDNINPAVYIVIAPYNKTDK----LAENTKLGVVSPQWIFDCVKK 75


                  ....*....
gi 51330093   603 QKMLPYQPY 611
Cdd:pfam16589  76 GKLLPLENY 84
BRCT pfam00533
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ...
 317-391 1.49e-14

BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.


Pssm-ID: 425736 [Multi-domain]  Cd Length: 75  Bit Score: 68.86  E-value: 1.49e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 51330093   317 PFNRILEGVVFVLSGFQNPFRADLRDKALALGARYRPDWTPDATHLICAfANTPKYSQVKAAGGIIVRKEWVMDC 391
Cdd:pfam00533   1 PKEKLFSGKTFVITGLDGLERDELKELIEKLGGKVTDSLSKKTTHVIVE-ARTKKYLKAKELGIPIVTEEWLLDC 74
BRCT_TopBP1_rpt2_like cd17731
second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 320-395 1.09e-11

second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the second BRCT domain.


Pssm-ID: 349363 [Multi-domain]  Cd Length: 77  Bit Score: 60.63  E-value: 1.09e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 51330093 320 RILEGVVFVLSGFQNPFRADLRDKALALGARYRPDWTPDATHLICAFANTPKYSQVKAAGGI-IVRKEWVMDCHKNK 395
Cdd:cd17731   1 PPFKGLVICVTGFDSEERKEIQQLVEQNGGSYSPDLSKNCTHLIAGSPSGQKYEFARKWNSIhIVTPEWLYDSIEAG 77
BRCT_DNA_ligase_III cd18431
BRCT domain of DNA ligase 3 (LIG3) and similar proteins; LIG3 (EC 6.5.1.1), also termed DNA ...
 523-607 3.04e-10

BRCT domain of DNA ligase 3 (LIG3) and similar proteins; LIG3 (EC 6.5.1.1), also termed DNA ligase III, or polydeoxyribonucleotide synthase [ATP] 3, functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.


Pssm-ID: 349384 [Multi-domain]  Cd Length: 78  Bit Score: 56.55  E-value: 3.04e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51330093 523 LPDFLKGKRFYLYGKFPDnQKRLLLRYIIAFNG-AVEDYMSEKVQFVITSEGWDDsfedalmENGSLSFVKPTWIFAIND 601
Cdd:cd18431   1 LPDIFTGVKVYLPGSVED-DYKKLKRYFIAYDGdVVEEYDEEDATHVVVDRDDKL-------GNPSAKVVSPEWLWDCIK 72


                ....*.
gi 51330093 602 RQKMLP 607
Cdd:cd18431  73 KQKLVP 78
BRCT smart00292
breast cancer carboxy-terminal domain;
321-391 4.84e-10

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 56.23  E-value: 4.84e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 51330093    321 ILEGVVFVLSG-FQNPFRADLRDKALALGARYRPDWT-PDATHLICAFANTPKYS--QVKAAGGIIVRKEWVMDC 391
Cdd:smart00292   3 LFKGKTFYITGsFDKEERDELKELIEALGGKVTSSLSsKTTTHVIVGSPEGGKLEllKAIALGIPIVKEEWLLDC 77
BRCT_CTDP1 cd17729
BRCT domain of RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1) and similar ...
 320-391 5.71e-10

BRCT domain of RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1) and similar proteins; CTDP1 (EC 3.1.3.16), also termed TFIIF-associating CTD phosphatase, or TFIIF- associating RNA polymerase C-terminal domain phosphatase (FCP1), promotes the activity of RNA polymerase II through processively dephosphorylating 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. It plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation.


Pssm-ID: 349361 [Multi-domain]  Cd Length: 97  Bit Score: 56.39  E-value: 5.71e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 51330093 320 RILEGVVFVLSGF----QNPFRADLRDKALALGARYRPDWTPDATHLICAFANTPKYSQVKAAGGI-IVRKEWVMDC 391
Cdd:cd17729  12 KVLKGCVIVFSGViptgIDPERSRLWKLAESLGAKVVTDLSPRTTHLVAAKLGTEKVKQALKMPGIhVVHPDWLWAC 88
PTCB-BRCT pfam12738
twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. ...
 329-387 9.18e-08

twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. BRCT domains are peptide- and phosphopeptide-binding modules. BRCT domains are present in a number of proteins involved in DNA checkpoint controls and DNA repair.


Pssm-ID: 463687 [Multi-domain]  Cd Length: 63  Bit Score: 49.12  E-value: 9.18e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 51330093   329 LSGFQNPFRADLRDKALALGARYRPDWTPDATHLICAFANTPKYSQVKAAGGIIVRKEW 387
Cdd:pfam12738   5 VTGFDGDDREGLQKLIEAMGAEYTKDLTKSVTHLICKSGEGEKYEKAKEWGIPVVSPLW 63
BRCT smart00292
breast cancer carboxy-terminal domain;
524-598 1.25e-07

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 49.30  E-value: 1.25e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 51330093    524 PDFLKGKRFYLYGKFPDNQKRLLLRYIIAFNGAVEDYMSEK-VQFVITSEGWDDSFEDALMENGSLSFVKPTWIFA 598
Cdd:smart00292   1 PKLFKGKTFYITGSFDKEERDELKELIEALGGKVTSSLSSKtTTHVIVGSPEGGKLELLKAIALGIPIVKEEWLLD 76
BRCT_TopBP1_rpt6 cd17727
sixth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 322-393 2.52e-07

sixth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the sixth BRCT domain.


Pssm-ID: 349359 [Multi-domain]  Cd Length: 75  Bit Score: 48.36  E-value: 2.52e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 51330093 322 LEGVVFVLSGFQNPFRADLRDKALALGARYRPDWTPDATHLICAFANTPKYSQVKAA---GGIIVRKEWVMDCHK 393
Cdd:cd17727   1 LKGVVICVSKKLSKRQGELNKIAASLGAEYRWTYDESCTHFIYQGKANDTNREYKSAkeqGKFIVSPHWLYACKE 75
BRCT_Rev1 cd17719
BRCT domain of DNA repair protein Rev1 and similar proteins; REV1, also termed alpha ...
 321-405 2.55e-07

BRCT domain of DNA repair protein Rev1 and similar proteins; REV1, also termed alpha integrin-binding protein 80, or AIBP80, or Rev1-like terminal deoxycytidyl transferase, is a DNA template-dependent dCMP transferase required for mutagenesis induced by UV light.


Pssm-ID: 349351 [Multi-domain]  Cd Length: 87  Bit Score: 48.72  E-value: 2.55e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51330093 321 ILEGVVFVLSGFQNPFRADLRDKALALGARYRPDWTPD-ATHLICAFANTPKYSQVKAAGGI-IVRKEWVMDCHKNKQKI 398
Cdd:cd17719   1 IFKGVVIYVNGYTDPSADELKRLILLHGGQYEHYYSRSrVTHIIATNLPGSKIKKLKKARNYkVVRPEWIVDSIKAGRLL 80


                ....*..
gi 51330093 399 SCKRYLM 405
Cdd:cd17719  81 PEAPYLL 87
BRCT_BRC1_like_rpt4 cd18438
fourth BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar ...
 326-391 3.07e-07

fourth BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. Members in this family contains six BRCT domains. This family corresponds to the fourth repeat.


Pssm-ID: 349391 [Multi-domain]  Cd Length: 68  Bit Score: 47.76  E-value: 3.07e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 51330093 326 VFVLSGFQNPFRADLRDKALALGARYRPDWTPDATHLICAFANTPKYSQVKAAGGIIVRKEWVMDC 391
Cdd:cd18438   2 KITITNYTGAARQYLEKLILALGATYTKNLKPDNTHLITASPEGEKYEAAKEWNIPIVNHLWLYDS 67
BRCT_2 pfam16589
BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found ...
 321-403 8.10e-07

BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found on many RAP1 proteins, usually at the very N-terminus. The function in human at least of a BRCT is to contribute to the heterogeneity of the telomere DNA length, but that may not be its general function, which remains unknown.


Pssm-ID: 465186 [Multi-domain]  Cd Length: 84  Bit Score: 46.97  E-value: 8.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51330093   321 ILEGVVFVLSGFQNPFRADLRDKALALGARYRPDWTPDATHLICAFANTPKysQVKAAGGIIVRKEWVMDCHKNKQKISC 400
Cdd:pfam16589   4 LFEPLRFYINAIPSPSRSKLKRLIEANGGTVVDNINPAVYIVIAPYNKTDK--LAENTKLGVVSPQWIFDCVKKGKLLPL 81


                  ...
gi 51330093   401 KRY 403
Cdd:pfam16589  82 ENY 84
BRCT_TopBP1_rpt7 cd17738
seventh BRCT domain of DNA topoisomerase 2-binding protein 1; TopBP1, also termed DNA ...
 326-395 1.57e-06

seventh BRCT domain of DNA topoisomerase 2-binding protein 1; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the seventh BRCT domain. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is missing in this group.


Pssm-ID: 349370 [Multi-domain]  Cd Length: 75  Bit Score: 46.02  E-value: 1.57e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 51330093 326 VFVLSGFQNPFRADLRDKALALGARY--RPDWTPDATHLICAfanTPKYSQvK-----AAGGIIVRKEWVMDCHKNK 395
Cdd:cd17738   3 VFLLSGFSEDEKKELISIIEKLGGKVldSDEFDPKCTHLICG---KPSRSE-KflaacAAGKWILHPSYIEASAKAG 75
BRCT_Rad4_rpt1 cd17740
first BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar ...
 320-393 3.15e-06

first BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar proteins; Rad4, also termed P74, or protein cut5, is an essential component for DNA replication and the checkpoint control system which couples the S and M phases. It may directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Rad4 contains four BRCT repeats. The family corresponds to the first one.


Pssm-ID: 349371  Cd Length: 82  Bit Score: 45.55  E-value: 3.15e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 51330093 320 RILEGVVFVLSGFQNPFRADLRDKALALGARYRPDWTPDATHLICAFANTPKYSQVKAAGG--IIVRKEWVMDCHK 393
Cdd:cd17740   1 KPLSGIVLCCTSIPAEQRTEIATKASKMGAAYTADLTSDVTHLVAGQVNTTKYKFAARSRPdiKVMTVEWVEHLYE 76
BRCT_PAXIP1_rpt3 cd17711
third BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 324-399 5.43e-06

third BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the third BRCT domain.


Pssm-ID: 349343  Cd Length: 81  Bit Score: 44.56  E-value: 5.43e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51330093 324 GVVFVLSGFQN----PFRADLRDKALALGARYRPDWTPDATHLICAFANTPKYSQVKAAGGIIVRKEWVMDCHKNKQKIS 399
Cdd:cd17711   1 GCVFFIADYPEqmgdQEIATWKKVIEEHGGEVVDEYSPRVTHVICESQDSPEYQQALRDGKRVVTAYWLNDVLKRGKLLP 80
BRCT_PAXIP1_rpt4 cd17730
fourth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 325-391 6.47e-06

fourth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the fourth BRCT domain.


Pssm-ID: 349362 [Multi-domain]  Cd Length: 73  Bit Score: 44.16  E-value: 6.47e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 51330093 325 VVFVLSGFQNPFRADLRDKALALGARYRPDWTPDATHLICAFANTPKYSQVKAAGGIIVRKEWVMDC 391
Cdd:cd17730   1 QVISVTGFDGSEREDIKRMIELMGAKYTGYLTRSNTHLICKRPEGEKYEKAKEWRIPVVNAQWLEDI 67
BRCT_microcephalin_rpt1 cd17716
first (N-terminal) BRCT domain of microcephalin and similar proteins; Microcephalin is a DNA ...
 325-396 6.24e-05

first (N-terminal) BRCT domain of microcephalin and similar proteins; Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. It has been implicated in chromosome condensation and DNA damage induced cellular responses. It may play a role in neurogenesis and regulation of the size of the cerebral cortex. Microcephalin contains three BRCT repeats. This family corresponds to the first repeat.


Pssm-ID: 349348 [Multi-domain]  Cd Length: 78  Bit Score: 41.41  E-value: 6.24e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 51330093 325 VVFV---LSGFQN---PFRADLRDkalaLGARYRPDWTPDATHLICAFANTPKYSQVKAAGGIIVRKEWVMDCHKNKQ 396
Cdd:cd17716   3 VAYVdvrSGDGADrssAFRSILEE----LGAKVVKRLTKTVTHVVFKDGSQSTLEKAKKRNVKLVSPLWVEACKETGK 76
BRCT_PAXIP1_rpt2 cd17710
second BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 321-400 8.05e-05

second BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the second BRCT domain.


Pssm-ID: 349342 [Multi-domain]  Cd Length: 81  Bit Score: 41.45  E-value: 8.05e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51330093 321 ILEGVVFVLSGFqnpfRADLRDKALAL----GARYRPDWTPDATHLICAFANTPKYSQVKAAGGI-IVRKEWVMDCHKNK 395
Cdd:cd17710   1 LFSGVVVCPSQI----SAEDRLKLWAMvtfhGGKCQLNLDKKCTHLVTGKASGAKYECALKHEGIkIVTPDWVTDCIKAK 76


                ....*
gi 51330093 396 QKISC 400
Cdd:cd17710  77 TLLDE 81
BRCT_CHS5_like cd17742
BRCT domain of yeast chitin biosynthesis protein CHS5 and similar proteins; CHS5, also termed ...
 339-395 2.45e-04

BRCT domain of yeast chitin biosynthesis protein CHS5 and similar proteins; CHS5, also termed protein CAL3, is a component of the CHS5/6 complex which mediates export of specific cargo proteins, including chitin synthase CHS3. It is also involved in targeting FUS1 to sites of polarized growth.


Pssm-ID: 349373 [Multi-domain]  Cd Length: 77  Bit Score: 40.01  E-value: 2.45e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 51330093 339 DLRDKALALGARYRPDWTPDATHLICAFANTPKYSQVKAAGGIIVRKEWVMDCHKNK 395
Cdd:cd17742  18 ELEQCLERIGAKPTDRVAIDTTHFVCTVPSGPEYEKAKEMNIPIVRPEWLRACEVEK 74
BRCT_Rad4_rpt2 cd17746
second BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and ...
 329-387 2.86e-04

second BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar proteins; Rad4, also termed P74, or protein cut5, is an essential component for DNA replication and the checkpoint control system which couples S and M phases. It may directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Rad4 contains four BRCT repeats. The family corresponds to the second one.


Pssm-ID: 349377 [Multi-domain]  Cd Length: 91  Bit Score: 40.30  E-value: 2.86e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 51330093 329 LSGFQNPFRADLRDKALALGARYRPDWTPDATHLICAFANTPKYSQVKAAGGIIVRKEW 387
Cdd:cd17746  14 LTNIGQPERSRIENYVLKHGGTFCPDLTRDVTHLIAGTSSGRKYEYALKWKINVVCVEW 72
BRCT_Bard1_rpt1 cd17734
first BRCT domain of BRCA1-associated RING domain protein 1 (Bard1) and similar proteins; ...
 325-398 5.63e-04

first BRCT domain of BRCA1-associated RING domain protein 1 (Bard1) and similar proteins; Bard1, also termed BARD-1, or RING-type E3 ubiquitin transferase BARD1, is a critical factor in BRCA1-mediated tumor suppression and may also serve as a target for tumorigenic lesions in some human cancers. It associates with BRCA1 (breast cancer-1) to form a heterodimeric BRCA1/BARD1 complex that is responsible for maintaining genomic stability through nuclear functions involving DNA damage signaling and repair, transcriptional regulation, and cell cycle control. The BRCA1/BARD1 complex catalyzes autoubiquitination of BRCA1 and trans ubiquitination of other protein substrates. Its E3 ligase activity is dramatically reduced in the presence of UBX domain protein 1 (UBXN1). BARD-1 contains an N-terminal C3HC4-type RING-HC finger that binds BRCA1, and a C-terminal region with three ankyrin repeats and tandem BRCT domains that bind CstF-50 (cleavage stimulation factor) to modulate mRNA processing and RNAP II stability in response to DNA damage. The family corresponds to the first BRCT domain.


Pssm-ID: 349366  Cd Length: 80  Bit Score: 39.12  E-value: 5.63e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51330093 325 VVFVLSGFQNPFRADLRDKALALGARYRPDWTPDATHLICAFA------NTPKYSQVKAAGGIIVRKEWVMDCHKNKQKI 398
Cdd:cd17734   1 LVLLGSGLSSEQKKLLEKLAQLLKAKVVTEFSPEVTHVVVPADergvcpRTMKYLMGILAGKWIVSFEWVEACLKAKKLV 80
BRCT_BRC1_like_rpt2 cd18436
second BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar ...
 345-393 1.16e-03

second BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. The family also includes Cryptococcus neoformans DNA ligase 4 (LIG4, also known as DNA ligase IV or polydeoxyribonucleotide synthase [ATP] 4), which is involved in dsDNA break repair, and plays a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologus end-joining. Members in this family contains six BRCT domains. This family corresponds to the second repeat.


Pssm-ID: 349389 [Multi-domain]  Cd Length: 75  Bit Score: 37.98  E-value: 1.16e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 51330093 345 LALGARYRPDWTPDATHLICAFANTPKYSQV---KAAGGIIVRKEWVMDCHK 393
Cdd:cd18436  24 LALGGQYSDELTRDVTHLIALSPDGDKYKTAlkrPELNIKIVLPHWFDDCFK 75
LIG3_BRCT pfam16759
DNA ligase 3 BRCT domain; The BRCT domain of DNA ligase 3 (LIG3) binds to the C-terminal BRCT ...
 523-596 1.27e-03

DNA ligase 3 BRCT domain; The BRCT domain of DNA ligase 3 (LIG3) binds to the C-terminal BRCT domain of the scaffolding protein X-ray repair cross-complementing protein 1 (XRCC1) and mediates homo- and heterodimerization.


Pssm-ID: 465260  Cd Length: 77  Bit Score: 37.73  E-value: 1.27e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 51330093   523 LPDFLKGKRFYLYGKFPDNQKrlLLRYIIAFNGA-VEDYMSEKVQFVITSEGWDDSFEDalmeNGSLSFVKPTWI 596
Cdd:pfam16759   2 LPDIFTGVRLFLPPSVPDFSK--LRRYFIAYDGDlVQEYDLDSATHVVVPKDSAKEKEE----SSGAKHVTASWI 70
BRCT_nibrin cd17741
BRCT domain of nibrin and similar proteins; Nibrin (NBN), also termed Nijmegen breakage ...
 325-393 5.09e-03

BRCT domain of nibrin and similar proteins; Nibrin (NBN), also termed Nijmegen breakage syndrome protein 1 (NBS1), or cell cycle regulatory protein p95, is a novel DNA double-strand break repair protein that is mutated in Nijmegen breakage syndrome. It is a component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The BRCT (Breast Cancer Suppressor Protein BRCA1, carboxy-terminal) domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/hetero BRCT multimers, BRCT-non-BRCT interactions, and interactions within DNA strand breaks. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is absent in this group.


Pssm-ID: 349372 [Multi-domain]  Cd Length: 74  Bit Score: 36.04  E-value: 5.09e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51330093 325 VVFVLSGFQNPFRADLRDKALALGARYRPDWTPDATHLICAFAN-TPKYSQVKAAGGIIVRKEWVMDCHK 393
Cdd:cd17741   3 LVVCSSCLDSEEKKKLKQIIAKLGGKVVNEWTEECTHLVMSKIKvTVKVICALISGKPIVTPEYLDALLE 72
BRCT_DNA_ligase_III cd18431
BRCT domain of DNA ligase 3 (LIG3) and similar proteins; LIG3 (EC 6.5.1.1), also termed DNA ...
 321-397 8.06e-03

BRCT domain of DNA ligase 3 (LIG3) and similar proteins; LIG3 (EC 6.5.1.1), also termed DNA ligase III, or polydeoxyribonucleotide synthase [ATP] 3, functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.


Pssm-ID: 349384 [Multi-domain]  Cd Length: 78  Bit Score: 35.75  E-value: 8.06e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 51330093 321 ILEGVVFVLSGFQNPFRADLRDKALALGARYRPDWTP-DATHLIcafanTPKYSQVKAAGGIIVRKEWVMDCHKNKQK 397
Cdd:cd18431   4 IFTGVKVYLPGSVEDDYKKLKRYFIAYDGDVVEEYDEeDATHVV-----VDRDDKLGNPSAKVVSPEWLWDCIKKQKL 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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