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Conserved domains on  [gi|50925441|gb|AAH78725|]
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Egfl7 protein [Rattus norvegicus]

Protein Classification

calcium-binding EGF-like domain-containing protein( domain architecture ID 11167512)

calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EMI pfam07546
EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final ...
 29-99 3.90e-18

EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al. This is to stop the family overlapping with other domains.


:

Pssm-ID: 462204  Cd Length: 69  Bit Score: 76.69  E-value: 3.90e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 50925441    29 RRVCTVGVSG---GSISETFVQRVYQPYLTTCDGHRACSTYRTIYRTAYRIAYRhspglTPSRPRYACCPGWKR 99
Cdd:pfam07546   1 RNVCAYKVVScvvVTGTESYVQPVYKPYLTWCAGHRRCSTYRTTYRPAYRQVYK-----TVTRLEWRCCPGWGG 69
EGF_CA pfam07645
Calcium-binding EGF domain;
142-171 1.55e-05

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 41.07  E-value: 1.55e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 50925441   142 DVDECSTGEARCPQR--CVNTVGSYWCQCWEG 171
Cdd:pfam07645   1 DVDECATGTHNCPANtvCVNTIGSFECRCPDG 32
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 116-139 9.36e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 33.09  E-value: 9.36e-03
                          10        20
                  ....*....|....*....|....*
gi 50925441   116 CGNEGSCIRP-GRCRCPVGWQGDTC 139
Cdd:pfam07974   2 CSGRGTCVNQcGKCVCDSGYQGATC 26
 
Name Accession Description Interval E-value
EMI pfam07546
EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final ...
 29-99 3.90e-18

EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al. This is to stop the family overlapping with other domains.


Pssm-ID: 462204  Cd Length: 69  Bit Score: 76.69  E-value: 3.90e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 50925441    29 RRVCTVGVSG---GSISETFVQRVYQPYLTTCDGHRACSTYRTIYRTAYRIAYRhspglTPSRPRYACCPGWKR 99
Cdd:pfam07546   1 RNVCAYKVVScvvVTGTESYVQPVYKPYLTWCAGHRRCSTYRTTYRPAYRQVYK-----TVTRLEWRCCPGWGG 69
EGF_CA pfam07645
Calcium-binding EGF domain;
142-171 1.55e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 41.07  E-value: 1.55e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 50925441   142 DVDECSTGEARCPQR--CVNTVGSYWCQCWEG 171
Cdd:pfam07645   1 DVDECATGTHNCPANtvCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
142-171 1.33e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 1.33e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 50925441    142 DVDECSTGEA-RCPQRCVNTVGSYWCQCWEG 171
Cdd:smart00179   1 DIDECASGNPcQNGGTCVNTVGSYRCECPPG 31
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 135-171 2.42e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 38.52  E-value: 2.42e-03
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 50925441 135 QGDTCQiDVDECSTGEARCPQRCVNTVGSYWCQCWEG 171
Cdd:cd01475 180 QGKICV-VPDLCATLSHVCQQVCISTPGSYLCACTEG 215
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 116-139 9.36e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 33.09  E-value: 9.36e-03
                          10        20
                  ....*....|....*....|....*
gi 50925441   116 CGNEGSCIRP-GRCRCPVGWQGDTC 139
Cdd:pfam07974   2 CSGRGTCVNQcGKCVCDSGYQGATC 26
 
Name Accession Description Interval E-value
EMI pfam07546
EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final ...
 29-99 3.90e-18

EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al. This is to stop the family overlapping with other domains.


Pssm-ID: 462204  Cd Length: 69  Bit Score: 76.69  E-value: 3.90e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 50925441    29 RRVCTVGVSG---GSISETFVQRVYQPYLTTCDGHRACSTYRTIYRTAYRIAYRhspglTPSRPRYACCPGWKR 99
Cdd:pfam07546   1 RNVCAYKVVScvvVTGTESYVQPVYKPYLTWCAGHRRCSTYRTTYRPAYRQVYK-----TVTRLEWRCCPGWGG 69
EGF_CA pfam07645
Calcium-binding EGF domain;
142-171 1.55e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 41.07  E-value: 1.55e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 50925441   142 DVDECSTGEARCPQR--CVNTVGSYWCQCWEG 171
Cdd:pfam07645   1 DVDECATGTHNCPANtvCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
142-171 1.33e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 1.33e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 50925441    142 DVDECSTGEA-RCPQRCVNTVGSYWCQCWEG 171
Cdd:smart00179   1 DIDECASGNPcQNGGTCVNTVGSYRCECPPG 31
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 135-171 2.42e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 38.52  E-value: 2.42e-03
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 50925441 135 QGDTCQiDVDECSTGEARCPQRCVNTVGSYWCQCWEG 171
Cdd:cd01475 180 QGKICV-VPDLCATLSHVCQQVCISTPGSYLCACTEG 215
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 116-139 9.36e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 33.09  E-value: 9.36e-03
                          10        20
                  ....*....|....*....|....*
gi 50925441   116 CGNEGSCIRP-GRCRCPVGWQGDTC 139
Cdd:pfam07974   2 CSGRGTCVNQcGKCVCDSGYQGATC 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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