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Conserved domains on  [gi|49522946|gb|AAH75243|]
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MGC84459 protein [Xenopus laevis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
3-213 4.82e-26

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 106.58  E-value: 4.82e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946   3 FLHGFRRIIFEYQPLVNEILGALGIQDPEQLGASDNSSSLLVGESEKLLALNGLLERHSQSSYYKEGVSYSLLKVAELGL 82
Cdd:COG0666  20 LLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGD 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946  83 VPPAKILLHYGADLSFEDPvTYYTVLHISVLRNQPEMVELLVQSGADINKRDRIHEsSPLDLASeESERLPCLQRLLELG 162
Cdd:COG0666 100 LEIVKLLLEAGADVNARDK-DGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGN-TPLHLAA-ANGNLEIVKLLLEAG 176

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 49522946 163 ADVNAADKNGKTALLHAlassdgVQIHNIENIRLLLEGGANVKATTKDYDT 213
Cdd:COG0666 177 ADVNARDNDGETPLHLA------AENGHLEIVKLLLEAGADVNAKDNDGKT 221
SOCS_ASB6 cd03725
SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a ...
 373-416 1.77e-24

SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor signaling complex. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


:

Pssm-ID: 239695  Cd Length: 44  Bit Score: 94.82  E-value: 1.77e-24
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 49522946 373 HSPPTLKHLCRVFIRQRLQPWPVDVKVKALPLPDRLKWYLLINH 416
Cdd:cd03725   1 SYPPPLKHLCRVFIRLCLRPWPVDVKVKALPLPDRLKWYLLPEH 44
PHA03100 super family cl39094
ankyrin repeat protein; Provisional
 146-289 2.13e-05

ankyrin repeat protein; Provisional


The actual alignment was detected with superfamily member PHA03100:

Pssm-ID: 476869 [Multi-domain]  Cd Length: 422  Bit Score: 46.58  E-value: 2.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946  146 SEESERLPCLQRLLELGADVNAADKNGKTaLLHALASSDGVQIHNIENIRLLLEGGANVKATtkdYDTVFSCIIFLLGET 225
Cdd:PHA03100  42 AKEARNIDVVKILLDNGADINSSTKNNST-PLHYLSNIKYNLTDVKEIVKLLLEYGANVNAP---DNNGITPLLYAISKK 117

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 49522946  226 MGcdqeEAKLINhfcfrvsqLLMAHGADPSECPSH-ESLTHTCLKSFKLHFPLLRFLLESGASYN 289
Cdd:PHA03100 118 SN----SYSIVE--------YLLDNGANVNIKNSDgENLLHLYLESNKIDLKILKLLIDKGVDIN 170
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
3-213 4.82e-26

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 106.58  E-value: 4.82e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946   3 FLHGFRRIIFEYQPLVNEILGALGIQDPEQLGASDNSSSLLVGESEKLLALNGLLERHSQSSYYKEGVSYSLLKVAELGL 82
Cdd:COG0666  20 LLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGD 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946  83 VPPAKILLHYGADLSFEDPvTYYTVLHISVLRNQPEMVELLVQSGADINKRDRIHEsSPLDLASeESERLPCLQRLLELG 162
Cdd:COG0666 100 LEIVKLLLEAGADVNARDK-DGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGN-TPLHLAA-ANGNLEIVKLLLEAG 176

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 49522946 163 ADVNAADKNGKTALLHAlassdgVQIHNIENIRLLLEGGANVKATTKDYDT 213
Cdd:COG0666 177 ADVNARDNDGETPLHLA------AENGHLEIVKLLLEAGADVNAKDNDGKT 221
SOCS_ASB6 cd03725
SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a ...
 373-416 1.77e-24

SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor signaling complex. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239695  Cd Length: 44  Bit Score: 94.82  E-value: 1.77e-24
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 49522946 373 HSPPTLKHLCRVFIRQRLQPWPVDVKVKALPLPDRLKWYLLINH 416
Cdd:cd03725   1 SYPPPLKHLCRVFIRLCLRPWPVDVKVKALPLPDRLKWYLLPEH 44
PHA03095 PHA03095
ankyrin-like protein; Provisional
 63-289 3.44e-14

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 73.91  E-value: 3.44e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946   63 SSYYKEGVSYSLLKVAELglvppaKILLHYGADLSFEDPVTYyTVLHISVLRNQP---EMVELLVQSGADINKRDRiHES 139
Cdd:PHA03095  13 AALYDYLLNASNVTVEEV------RRLLAAGADVNFRGEYGK-TPLHLYLHYSSEkvkDIVRLLLEAGADVNAPER-CGF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946  140 SPLDLASEESERLPCLQRLLELGADVNAADKNGKTAlLHALASSDGVqihNIENIRLLLEGGANVKATTKDYDTVFSCII 219
Cdd:PHA03095  85 TPLHLYLYNATTLDVIKLLIKAGADVNAKDKVGRTP-LHVYLSGFNI---NPKVIRLLLRKGADVNALDLYGMTPLAVLL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946  220 -----------FLLgeTMGCDQEEAK-----LINHFC------FRVSQLLMAHGADPS------ECPSHESLTHTCLKSf 271
Cdd:PHA03095 161 ksrnanvellrLLI--DAGADVYAVDdrfrsLLHHHLqsfkprARIVRELIRAGCDPAatdmlgNTPLHSMATGSSCKR- 237

                        250
                 ....*....|....*...
gi 49522946  272 klhfPLLRFLLESGASYN 289
Cdd:PHA03095 238 ----SLVLPLLIAGISIN 251
Ank_2 pfam12796
Ankyrin repeats (3 copies);
74-169 1.87e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 54.35  E-value: 1.87e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946    74 LLKVAELGLVPPAKILLHYGADLSFEDPvTYYTVLHISVLRNQPEMVELLVQSgadINKRDRIHESSPLDLASeESERLP 153
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDK-NGRTALHLAAKNGHLEIVKLLLEH---ADVNLKDNGRTALHYAA-RSGHLE 75

                          90
                  ....*....|....*.
gi 49522946   154 CLQRLLELGADVNAAD 169
Cdd:pfam12796  76 IVKLLLEKGADINVKD 91
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 374-413 2.24e-09

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 52.55  E-value: 2.24e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 49522946   374 SPPTLKHLCRVFIRQRLQPWPVDvKVKALPLPDRLKWYLL 413
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLG-AIDKLPLPPLLKDYLL 39
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 376-413 4.07e-06

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 43.17  E-value: 4.07e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 49522946    376 PTLKHLCRVFIRQRLQpwpvdvKVKALPLPDRLKWYLL 413
Cdd:smart00969   1 RSLQHLCRLAIRRSLG------GIDKLPLPPRLKDYLL 32
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 146-289 2.13e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 46.58  E-value: 2.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946  146 SEESERLPCLQRLLELGADVNAADKNGKTaLLHALASSDGVQIHNIENIRLLLEGGANVKATtkdYDTVFSCIIFLLGET 225
Cdd:PHA03100  42 AKEARNIDVVKILLDNGADINSSTKNNST-PLHYLSNIKYNLTDVKEIVKLLLEYGANVNAP---DNNGITPLLYAISKK 117

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 49522946  226 MGcdqeEAKLINhfcfrvsqLLMAHGADPSECPSH-ESLTHTCLKSFKLHFPLLRFLLESGASYN 289
Cdd:PHA03100 118 SN----SYSIVE--------YLLDNGANVNIKNSDgENLLHLYLESNKIDLKILKLLIDKGVDIN 170
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 14-181 1.26e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 44.30  E-value: 1.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946    14 YQPLVNEilGALGIQDPEQLGasDNSSSLLVGESEkLLALNGLLERHSQSSYykegVSYSLLKVAELGLV---------- 83
Cdd:TIGR00870  34 YRDLEEP--KKLNINCPDRLG--RSALFVAAIENE-NLELTELLLNLSCRGA----VGDTLLHAISLEYVdaveaillhl 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946    84 ---PPAKILLHYGADLSFEDPVTYYTVLHISVLRNQPEMVELLVQSGADINKR---DRIHESSPLDLASEESERL----- 152
Cdd:TIGR00870 105 laaFRKSGPLELANDQYTSEFTPGITALHLAAHRQNYEIVKLLLERGASVPARacgDFFVKSQGVDSFYHGESPLnaaac 184

                         170       180       190
                  ....*....|....*....|....*....|...
gi 49522946   153 ---PCLQRLL-ELGADVNAADKNGKTaLLHALA 181
Cdd:TIGR00870 185 lgsPSIVALLsEDPADILTADSLGNT-LLHLLV 216
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 38-181 7.38e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 41.92  E-value: 7.38e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946  38 NSSSLLVGESEK-LLALNGLLERHSQSSYYKEGVSYSLLKVAEL-GLVPPAKILLHYGADLSFEdPVT--YY---TVLHI 110
Cdd:cd22192  17 SESPLLLAAKENdVQAIKKLLKCPSCDLFQRGALGETALHVAALyDNLEAAVVLMEAAPELVNE-PMTsdLYqgeTALHI 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946 111 SVLRNQPEMVELLVQSGADINK--------RDRIHE-----SSPLDLA----SEESERLpclqrLLELGADVNAADKNGK 173
Cdd:cd22192  96 AVVNQNLNLVRELIARGADVVSpratgtffRPGPKNliyygEHPLSFAacvgNEEIVRL-----LIEHGADIRAQDSLGN 170


                ....*...
gi 49522946 174 TaLLHALA 181
Cdd:cd22192 171 T-VLHILV 177
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 105-132 1.34e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.03  E-value: 1.34e-03
                           10        20
                   ....*....|....*....|....*...
gi 49522946    105 YTVLHISVLRNQPEMVELLVQSGADINK 132
Cdd:smart00248   3 RTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
3-213 4.82e-26

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 106.58  E-value: 4.82e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946   3 FLHGFRRIIFEYQPLVNEILGALGIQDPEQLGASDNSSSLLVGESEKLLALNGLLERHSQSSYYKEGVSYSLLKVAELGL 82
Cdd:COG0666  20 LLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGD 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946  83 VPPAKILLHYGADLSFEDPvTYYTVLHISVLRNQPEMVELLVQSGADINKRDRIHEsSPLDLASeESERLPCLQRLLELG 162
Cdd:COG0666 100 LEIVKLLLEAGADVNARDK-DGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGN-TPLHLAA-ANGNLEIVKLLLEAG 176

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 49522946 163 ADVNAADKNGKTALLHAlassdgVQIHNIENIRLLLEGGANVKATTKDYDT 213
Cdd:COG0666 177 ADVNARDNDGETPLHLA------AENGHLEIVKLLLEAGADVNAKDNDGKT 221
SOCS_ASB6 cd03725
SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a ...
 373-416 1.77e-24

SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor signaling complex. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239695  Cd Length: 44  Bit Score: 94.82  E-value: 1.77e-24
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 49522946 373 HSPPTLKHLCRVFIRQRLQPWPVDVKVKALPLPDRLKWYLLINH 416
Cdd:cd03725   1 SYPPPLKHLCRVFIRLCLRPWPVDVKVKALPLPDRLKWYLLPEH 44
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
18-254 1.44e-22

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 96.95  E-value: 1.44e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946  18 VNEILGALGIQDPEQLGASDNSSSLLVGESEKLLALNGLLERHSQSSYYKEGVSYSLLKVAELGLVPPAKILLHYGADLS 97
Cdd:COG0666   1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946  98 FEDPVTYYTVLHISVLRNQPEMVELLVQSGADINKRDRIHEsSPLDLASEEsERLPCLQRLLELGADVNAADKNGKTALL 177
Cdd:COG0666  81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGE-TPLHLAAYN-GNLEIVKLLLEAGADVNAQDNDGNTPLH 158

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 49522946 178 HAlassdgVQIHNIENIRLLLEGGANVKATTKDYDTVfsciifLLGETMGCDQEEAKlinhfcfrvsqLLMAHGADP 254
Cdd:COG0666 159 LA------AANGNLEIVKLLLEAGADVNARDNDGETP------LHLAAENGHLEIVK-----------LLLEAGADV 212
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
86-213 3.04e-21

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 93.09  E-value: 3.04e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946  86 AKILLHYGADLSFEDPvTYYTVLHISVLRNQPEMVELLVQSGADINKRDRiHESSPLDLASEeSERLPCLQRLLELGADV 165
Cdd:COG0666 136 VKLLLEAGADVNAQDN-DGNTPLHLAAANGNLEIVKLLLEAGADVNARDN-DGETPLHLAAE-NGHLEIVKLLLEAGADV 212

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 49522946 166 NAADKNGKTALLHAlassdgVQIHNIENIRLLLEGGANVKATTKDYDT 213
Cdd:COG0666 213 NAKDNDGKTALDLA------AENGNLEIVKLLLEAGADLNAKDKDGLT 254
PHA03095 PHA03095
ankyrin-like protein; Provisional
 63-289 3.44e-14

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 73.91  E-value: 3.44e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946   63 SSYYKEGVSYSLLKVAELglvppaKILLHYGADLSFEDPVTYyTVLHISVLRNQP---EMVELLVQSGADINKRDRiHES 139
Cdd:PHA03095  13 AALYDYLLNASNVTVEEV------RRLLAAGADVNFRGEYGK-TPLHLYLHYSSEkvkDIVRLLLEAGADVNAPER-CGF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946  140 SPLDLASEESERLPCLQRLLELGADVNAADKNGKTAlLHALASSDGVqihNIENIRLLLEGGANVKATTKDYDTVFSCII 219
Cdd:PHA03095  85 TPLHLYLYNATTLDVIKLLIKAGADVNAKDKVGRTP-LHVYLSGFNI---NPKVIRLLLRKGADVNALDLYGMTPLAVLL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946  220 -----------FLLgeTMGCDQEEAK-----LINHFC------FRVSQLLMAHGADPS------ECPSHESLTHTCLKSf 271
Cdd:PHA03095 161 ksrnanvellrLLI--DAGADVYAVDdrfrsLLHHHLqsfkprARIVRELIRAGCDPAatdmlgNTPLHSMATGSSCKR- 237

                        250
                 ....*....|....*...
gi 49522946  272 klhfPLLRFLLESGASYN 289
Cdd:PHA03095 238 ----SLVLPLLIAGISIN 251
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
74-208 3.88e-14

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 72.68  E-value: 3.88e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946  74 LLKVAELGLVPPAKILLHYGADLSFEDPvTYYTVLHISVLRNQPEMVELLVQSGADINKRDRIHEsSPLDLAsEESERLP 153
Cdd:COG0666 157 LHLAAANGNLEIVKLLLEAGADVNARDN-DGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGK-TALDLA-AENGNLE 233

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 49522946 154 CLQRLLELGADVNAADKNGKTALLHALASSDGVQIHNIENIRLLLEGGANVKATT 208
Cdd:COG0666 234 IVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 373-413 9.97e-13

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 62.13  E-value: 9.97e-13
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 49522946 373 HSPPTLKHLCRVFIRQRLQPWPvDVKVKALPLPDRLKWYLL 413
Cdd:cd03716   1 STPRSLQHLCRLAIRRCLGRRR-LELIKKLPLPPRLKDYLL 40
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 37-220 2.69e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 68.15  E-value: 2.69e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946   37 DNSSSLLVGESEKLLALNGLlerhSQSSYYKEGVS----YSLLKVAELGLVppaKILLHYGADLsfeDPVTYY--TVLHI 110
Cdd:PHA03100  78 IKYNLTDVKEIVKLLLEYGA----NVNAPDNNGITpllyAISKKSNSYSIV---EYLLDNGANV---NIKNSDgeNLLHL 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946  111 SVLRNQP--EMVELLVQSGADINKRDRIhesspldlaseeserlpclQRLLELGADVNAADKNGKTALLHAlassdgVQI 188
Cdd:PHA03100 148 YLESNKIdlKILKLLIDKGVDINAKNRV-------------------NYLLSYGVPINIKDVYGFTPLHYA------VYN 202

                        170       180       190
                 ....*....|....*....|....*....|..
gi 49522946  189 HNIENIRLLLEGGANVKATTKDYDTvfsCIIF 220
Cdd:PHA03100 203 NNPEFVKYLLDLGANPNLVNKYGDT---PLHI 231
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 374-413 1.70e-11

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 58.64  E-value: 1.70e-11
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 49522946 374 SPPTLKHLCRVFIRQRLQPWPVDvKVKALPLPDRLKWYLL 413
Cdd:cd03587   1 NPRSLQHLCRLAIRRCLGKRRLD-LIDKLPLPPRLKDYLL 39
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 87-209 9.79e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 63.15  E-value: 9.79e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946   87 KILLHYGADLSFEDpVTYYTVLHI-----SVLRNQPEMVELLVQSGADINKRDRIHESSPLDLASEESERLPCLQRLLEL 161
Cdd:PHA03100  52 KILLDNGADINSST-KNNSTPLHYlsnikYNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKKSNSYSIVEYLLDN 130

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 49522946  162 GADVNAADKNGKTaLLHALASSDGVqihNIENIRLLLEGGANVKATTK 209
Cdd:PHA03100 131 GANVNIKNSDGEN-LLHLYLESNKI---DLKILKLLIDKGVDINAKNR 174
Ank_2 pfam12796
Ankyrin repeats (3 copies);
74-169 1.87e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 54.35  E-value: 1.87e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946    74 LLKVAELGLVPPAKILLHYGADLSFEDPvTYYTVLHISVLRNQPEMVELLVQSgadINKRDRIHESSPLDLASeESERLP 153
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDK-NGRTALHLAAKNGHLEIVKLLLEH---ADVNLKDNGRTALHYAA-RSGHLE 75

                          90
                  ....*....|....*.
gi 49522946   154 CLQRLLELGADVNAAD 169
Cdd:pfam12796  76 IVKLLLEKGADINVKD 91
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 374-413 2.24e-09

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 52.55  E-value: 2.24e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 49522946   374 SPPTLKHLCRVFIRQRLQPWPVDvKVKALPLPDRLKWYLL 413
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLG-AIDKLPLPPLLKDYLL 39
Ank_2 pfam12796
Ankyrin repeats (3 copies);
108-207 5.06e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 53.20  E-value: 5.06e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946   108 LHISVLRNQPEMVELLVQSGADINKRDRIHEsSPLDLASeESERLPCLQRLLElGADVNAADkNGKTALLHALASsdgvq 187
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGR-TALHLAA-KNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARS----- 71

                          90       100
                  ....*....|....*....|
gi 49522946   188 iHNIENIRLLLEGGANVKAT 207
Cdd:pfam12796  72 -GHLEIVKLLLEKGADINVK 90
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 87-206 8.29e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 57.20  E-value: 8.29e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946   87 KILLHYGADLSFEDPVTYYTVLHISVLRNQPEMVELLVQSGADINKRDRIhESSPLDLASEESeRLPCLQRLLELGADVN 166
Cdd:PHA02878 151 KLLLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKT-NNSPLHHAVKHY-NKPIVHILLENGASTD 228

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 49522946  167 AADKNGKTALLHALASsdgvqIHNIENIRLLLEGGANVKA 206
Cdd:PHA02878 229 ARDKCGNTPLHISVGY-----CKDYDILKLLLEHGVDVNA 263
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 42-213 4.31e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 52.37  E-value: 4.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946   42 LLVGEseklLALNGLLERHSQSSYYKEGVSYSllkvAELGLVPPAKILLHYGADLSFeDPVTYYTVLHISVLRNQPEMVE 121
Cdd:PHA02876 158 LLIAE----MLLEGGADVNAKDIYCITPIHYA----AERGNAKMVNLLLSYGADVNI-IALDDLSVLECAVDSKNIDTIK 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946  122 LLVQSGADINKRD----------------------------RIHESSPLDLASEESERLPCLQRLLELGADVNAADKNGK 173
Cdd:PHA02876 229 AIIDNRSNINKNDlsllkairnedletslllydagfsvnsiDDCKNTPLHHASQAPSLSRLVPKLLERGADVNAKNIKGE 308

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 49522946  174 TALLhaLASSDGvqiHNIENIRLLLEGGANVKATTKDYDT 213
Cdd:PHA02876 309 TPLY--LMAKNG---YDTENIRTLIMLGADVNAADRLYIT 343
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 86-242 6.46e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 51.42  E-value: 6.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946   86 AKILLHYGADLSFEDPVTYYTVLHISVLRNQPeMVELLVQSGADINKRDRiHESSPLDLASEESERLPCLQRLLELGADV 165
Cdd:PHA02878 184 TELLLSYGANVNIPDKTNNSPLHHAVKHYNKP-IVHILLENGASTDARDK-CGNTPLHISVGYCKDYDILKLLLEHGVDV 261

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 49522946  166 NAADKNGKTALLHalassdgVQIHNIENIRLLLEGGANVKATTKDYDTVFSCIIfllgETMGCDQEEAKLINHFCFR 242
Cdd:PHA02878 262 NAKSYILGLTALH-------SSIKSERKLKLLLEYGADINSLNSYKLTPLSSAV----KQYLCINIGRILISNICLL 327
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 89-205 1.27e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 50.83  E-value: 1.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946   89 LLHYGADL-SFEDPVTyyTVLHISVLRNQPEM-VELLVQSGADINKRDRiHESSPLDLASEESERLPCLQRLLELGADVN 166
Cdd:PHA02876 394 LLDYGADIeALSQKIG--TALHFALCGTNPYMsVKTLIDRGANVNSKNK-DLSTPLHYACKKNCKLDVIEMLLDNGADVN 470

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 49522946  167 AADKNGKTALLHALassdgvQIHNIENIrlLLEGGANVK 205
Cdd:PHA02876 471 AINIQNQYPLLIAL------EYHGIVNI--LLHYGAELR 501
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 118-210 2.91e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 47.89  E-value: 2.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946  118 EMVELLVQSGADINKRDRIHESSPLD--LASEESERLPCLQRLLELGADVNAADKNGKTaLLHALASSDGVqihNIENIR 195
Cdd:PHA02859  67 EILKFLIENGADVNFKTRDNNLSALHhyLSFNKNVEPEILKILIDSGSSITEEDEDGKN-LLHMYMCNFNV---RINVIK 142

                         90
                 ....*....|....*
gi 49522946  196 LLLEGGANVKATTKD 210
Cdd:PHA02859 143 LLIDSGVSFLNKDFD 157
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 376-413 4.07e-06

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 43.17  E-value: 4.07e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 49522946    376 PTLKHLCRVFIRQRLQpwpvdvKVKALPLPDRLKWYLL 413
Cdd:smart00969   1 RSLQHLCRLAIRRSLG------GIDKLPLPPRLKDYLL 32
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 120-176 1.12e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 47.59  E-value: 1.12e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 49522946  120 VELLVQSGADINKRDrIHESSPLDLASEESeRLPCLQRLLELGADVNAADKNGKTAL 176
Cdd:PTZ00322  98 ARILLTGGADPNCRD-YDGRTPLHIACANG-HVQVVRVLLEFGADPTLLDKDGKTPL 152
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 56-217 1.16e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 47.29  E-value: 1.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946   56 LLERHSQSSYYKE-GVSYSLLKVAELGLVPPAKILLHYGadlSFEDPVTY---YTVLHISVLRNQPEMVELLVQSGAD-- 129
Cdd:PHA02875  53 LLMKHGAIPDVKYpDIESELHDAVEEGDVKAVEELLDLG---KFADDVFYkdgMTPLHLATILKKLDIMKLLIARGADpd 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946  130 INKRDRiheSSPLDLASEeSERLPCLQRLLELGADVNAADKNGKTALLHALASSdgvqihNIENIRLLLEGGANVKATTK 209
Cdd:PHA02875 130 IPNTDK---FSPLHLAVM-MGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKG------DIAICKMLLDSGANIDYFGK 199


                 ....*...
gi 49522946  210 DYDTVFSC 217
Cdd:PHA02875 200 NGCVAALC 207
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 87-213 1.36e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 47.37  E-value: 1.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946   87 KILLHYGADLSFEDPVtYYTVLH-ISVLRNQPEMVELLVQSGADINKRDrIHESSPLDLASEESErLPCLQRLLELGADV 165
Cdd:PHA02876 325 RTLIMLGADVNAADRL-YITPLHqASTLDRNKDIVITLLELGANVNARD-YCDKTPIHYAAVRNN-VVIINTLLDYGADI 401

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 49522946  166 NAADKNGKTALLHALASSDGVQihnieNIRLLLEGGANVKATTKDYDT 213
Cdd:PHA02876 402 EALSQKIGTALHFALCGTNPYM-----SVKTLIDRGANVNSKNKDLST 444
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 118-215 1.53e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 47.37  E-value: 1.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946  118 EMVELLVQSGADINKRDRIHeSSPLDLASEESERLPCLQRLLELGADVNAADKNGKTAlLHALASSDGVQIhnienIRLL 197
Cdd:PHA02876 322 ENIRTLIMLGADVNAADRLY-ITPLHQASTLDRNKDIVITLLELGANVNARDYCDKTP-IHYAAVRNNVVI-----INTL 394

                         90
                 ....*....|....*...
gi 49522946  198 LEGGANVKATTKDYDTVF 215
Cdd:PHA02876 395 LDYGADIEALSQKIGTAL 412
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 84-191 1.74e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 46.80  E-value: 1.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946   84 PPAKILLHYGADLSFEDPVTYyTVLHISVLR-NQPEMVELLVQSGADINKRDRIHESSPLDLaSEESERLpcLQRLLELG 162
Cdd:PHA02878 215 PIVHILLENGASTDARDKCGN-TPLHISVGYcKDYDILKLLLEHGVDVNAKSYILGLTALHS-SIKSERK--LKLLLEYG 290

                         90       100
                 ....*....|....*....|....*....
gi 49522946  163 ADVNAADKNGKTALLHALASSDGVQIHNI 191
Cdd:PHA02878 291 ADINSLNSYKLTPLSSAVKQYLCINIGRI 319
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 146-289 2.13e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 46.58  E-value: 2.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946  146 SEESERLPCLQRLLELGADVNAADKNGKTaLLHALASSDGVQIHNIENIRLLLEGGANVKATtkdYDTVFSCIIFLLGET 225
Cdd:PHA03100  42 AKEARNIDVVKILLDNGADINSSTKNNST-PLHYLSNIKYNLTDVKEIVKLLLEYGANVNAP---DNNGITPLLYAISKK 117

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 49522946  226 MGcdqeEAKLINhfcfrvsqLLMAHGADPSECPSH-ESLTHTCLKSFKLHFPLLRFLLESGASYN 289
Cdd:PHA03100 118 SN----SYSIVE--------YLLDNGANVNIKNSDgENLLHLYLESNKIDLKILKLLIDKGVDIN 170
Ank_4 pfam13637
Ankyrin repeats (many copies);
138-184 3.14e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.11  E-value: 3.14e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 49522946   138 ESSPLDLASEeSERLPCLQRLLELGADVNAADKNGKTALLHALASSD 184
Cdd:pfam13637   1 ELTALHAAAA-SGHLELLRLLLEKGADINAVDGNGETALHFAASNGN 46
PHA02798 PHA02798
ankyrin-like protein; Provisional
 102-210 4.49e-05

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 45.60  E-value: 4.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946  102 VTYYTVLHISVLRNQP--EMVELLVQSGADINKRDRiHESSPL-DLAS---EESERLPCLQRLLELGADVNAADKNGKTA 175
Cdd:PHA02798  34 VNEYSIFQKYLQRDSPstDIVKLFINLGANVNGLDN-EYSTPLcTILSnikDYKHMLDIVKILIENGADINKKNSDGETP 112

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 49522946  176 LLHALASSdgvQIHNIENIRLLLEGGANVKATTKD 210
Cdd:PHA02798 113 LYCLLSNG---YINNLEILLFMIENGADTTLLDKD 144
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 48-203 4.71e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 45.37  E-value: 4.71e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946   48 EKLLALNglleRHSQSSYYKEGVSySLLKVAELGLVPPAKILLHYGADLSFEDpVTYYTVLHISVLRNQPEMVELLVQSG 127
Cdd:PHA02875  85 EELLDLG----KFADDVFYKDGMT-PLHLATILKKLDIMKLLIARGADPDIPN-TDKFSPLHLAVMMGDIKGIELLIDHK 158

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 49522946  128 ADINKRDrIHESSPLDLASEESERLPClQRLLELGADVNAADKNGKTALLhalasSDGVQIHNIENIRLLLEGGAN 203
Cdd:PHA02875 159 ACLDIED-CCGCTPLIIAMAKGDIAIC-KMLLDSGANIDYFGKNGCVAAL-----CYAIENNKIDIVRLFIKRGAD 227
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 105-211 6.92e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 45.05  E-value: 6.92e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946  105 YTVLHISVLRNQP-----------EMVELLVQSGADINKRDrIHESSPLDLASEESERLPCLQRLLELGADVNAADKNGK 173
Cdd:PHA02876 264 FSVNSIDDCKNTPlhhasqapslsRLVPKLLERGADVNAKN-IKGETPLYLMAKNGYDTENIRTLIMLGADVNAADRLYI 342

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 49522946  174 TAlLHALASSDgvqiHNIENIRLLLEGGANVKAttKDY 211
Cdd:PHA02876 343 TP-LHQASTLD----RNKDIVITLLELGANVNA--RDY 373
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 14-181 1.26e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 44.30  E-value: 1.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946    14 YQPLVNEilGALGIQDPEQLGasDNSSSLLVGESEkLLALNGLLERHSQSSYykegVSYSLLKVAELGLV---------- 83
Cdd:TIGR00870  34 YRDLEEP--KKLNINCPDRLG--RSALFVAAIENE-NLELTELLLNLSCRGA----VGDTLLHAISLEYVdaveaillhl 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946    84 ---PPAKILLHYGADLSFEDPVTYYTVLHISVLRNQPEMVELLVQSGADINKR---DRIHESSPLDLASEESERL----- 152
Cdd:TIGR00870 105 laaFRKSGPLELANDQYTSEFTPGITALHLAAHRQNYEIVKLLLERGASVPARacgDFFVKSQGVDSFYHGESPLnaaac 184

                         170       180       190
                  ....*....|....*....|....*....|...
gi 49522946   153 ---PCLQRLL-ELGADVNAADKNGKTaLLHALA 181
Cdd:TIGR00870 185 lgsPSIVALLsEDPADILTADSLGNT-LLHLLV 216
PHA03095 PHA03095
ankyrin-like protein; Provisional
 53-185 1.38e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 43.86  E-value: 1.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946   53 LNGLLERHSQSSYYKEGVSYSLLkvaELGLVPPAKILLHYGADLSfedpVTYYTVLHISVLRNqpemvelLVQSGADINK 132
Cdd:PHA03095 187 FRSLLHHHLQSFKPRARIVRELI---RAGCDPAATDMLGNTPLHS----MATGSSCKRSLVLP-------LLIAGISINA 252

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 49522946  133 RDRiHESSPLDLASEESERLPCLqRLLELGADVNAADKNGKTALLHALASSDG 185
Cdd:PHA03095 253 RNR-YGQTPLHYAAVFNNPRACR-RLIALGADINAVSSDGNTPLSLMVRNNNG 303
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 69-204 1.47e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 43.80  E-value: 1.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946   69 GVSYSLLKVAELGlVPPAKILLHYGADLSFEDpVTYYTVLHISVLRNQPEMVELLVQSGADINKRDrIHESSPLDLASeE 148
Cdd:PHA02874  91 GVDTSILPIPCIE-KDMIKTILDCGIDVNIKD-AELKTFLHYAIKKGDLESIKMLFEYGADVNIED-DNGCYPIHIAI-K 166

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 49522946  149 SERLPCLQRLLELGADVNAADKNGKTALLHALASSDgvqihnIENIRLLLEGGANV 204
Cdd:PHA02874 167 HNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGD------YACIKLLIDHGNHI 216
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 374-413 1.61e-04

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 38.73  E-value: 1.61e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 49522946 374 SPPTLKHLCRVFIRQRLqpwPVDvKVKALPLPDRLKWYLL 413
Cdd:cd03717   2 SVRSLQHLCRFVIRQCT---RRD-LIDQLPLPRRLKDYLK 37
PHA02798 PHA02798
ankyrin-like protein; Provisional
 118-219 1.69e-04

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 43.67  E-value: 1.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946  118 EMVELLVQSGADINKRDRIHESsPLD--LASEESERLPCLQRLLELGADVNAADKNGKTALLHALASSDGVQihnIENIR 195
Cdd:PHA02798  90 DIVKILIENGADINKKNSDGET-PLYclLSNGYINNLEILLFMIENGADTTLLDKDGFTMLQVYLQSNHHID---IEIIK 165

                         90       100
                 ....*....|....*....|....*
gi 49522946  196 LLLEGGANVKA-TTKDYDTVFSCII 219
Cdd:PHA02798 166 LLLEKGVDINThNNKEKYDTLHCYF 190
PHA03095 PHA03095
ankyrin-like protein; Provisional
 87-210 1.73e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 43.86  E-value: 1.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946   87 KILLHYGADLSFEDpVTYYTVLHI--SVLRNQPEMVELLVQSGADINKRDRIHESSPLDLASEESERLPCLQRLLELGAD 164
Cdd:PHA03095 171 RLLIDAGADVYAVD-DRFRSLLHHhlQSFKPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVLPLLIAGIS 249

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 49522946  165 VNAADKNGKTALLHALASSdgvqihNIENIRLLLEGGANVKATTKD 210
Cdd:PHA03095 250 INARNRYGQTPLHYAAVFN------NPRACRRLIALGADINAVSSD 289
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 105-135 7.00e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.88  E-value: 7.00e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 49522946   105 YTVLHISVLR-NQPEMVELLVQSGADINKRDR 135
Cdd:pfam00023   3 NTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 38-181 7.38e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 41.92  E-value: 7.38e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946  38 NSSSLLVGESEK-LLALNGLLERHSQSSYYKEGVSYSLLKVAEL-GLVPPAKILLHYGADLSFEdPVT--YY---TVLHI 110
Cdd:cd22192  17 SESPLLLAAKENdVQAIKKLLKCPSCDLFQRGALGETALHVAALyDNLEAAVVLMEAAPELVNE-PMTsdLYqgeTALHI 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946 111 SVLRNQPEMVELLVQSGADINK--------RDRIHE-----SSPLDLA----SEESERLpclqrLLELGADVNAADKNGK 173
Cdd:cd22192  96 AVVNQNLNLVRELIARGADVVSpratgtffRPGPKNliyygEHPLSFAacvgNEEIVRL-----LIEHGADIRAQDSLGN 170


                ....*...
gi 49522946 174 TaLLHALA 181
Cdd:cd22192 171 T-VLHILV 177
TRPV1 cd22196
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 ...
 103-180 1.08e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 (TRPV1), a capsaicin (vanilloid) receptor, is the founding member of the vanilloid TRP subfamily (TRPV). In humans, it is expressed in the brain, kidney, pancreas, testis, uterus, spleen, stomach, small intestine, lung and liver. TRPV1 has been implicated to have function in thermo-sensation (heat), autonomic thermoregulation, nociception, food intake regulation, and multiple functions in the gastrointestinal (GI) tract. The receptor has also been involved in growth cone guidance, long-term depression, endocannabinoid signaling and osmosensing in the central nervous system. TRPV1 is up regulated in several human pathological conditions including vulvodynia, GI inflammation, Crohn's disease and ulcerative colitis. TRPV1 knock-out mice exhibit impaired sensation to thermal-mechanical acute pain. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411980 [Multi-domain]  Cd Length: 649  Bit Score: 41.33  E-value: 1.08e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946 103 TYY---TVLHISVLRNQPEMVELLVQSGADINKR------DRIHESS-------PLDLASeESERLPCLQRLLE---LGA 163
Cdd:cd22196  90 SYYkgqTALHIAIERRNMHLVELLVQNGADVHARasgeffKKKKGGPgfyfgelPLSLAA-CTNQLDIVKFLLEnphSPA 168

                        90
                ....*....|....*..
gi 49522946 164 DVNAADKNGKTaLLHAL 180
Cdd:cd22196 169 DISARDSMGNT-VLHAL 184
SOCS_SOCS2 cd03736
SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the ...
 374-412 1.20e-03

SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate neuronal differentiation by controlling expression of a neurogenic transcription factor, Neurogenin-1. SOCS2 binds to GH receptors and inhibits the activation of STAT5b induced by GH. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239705  Cd Length: 41  Bit Score: 36.36  E-value: 1.20e-03
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 49522946 374 SPPTLKHLCRVFIRQrlqpwpVDVKVKALPLPDRLKWYL 412
Cdd:cd03736   2 STPSLQHLCRITINK------CTRQIQELPLPTRLKDYL 34
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 105-132 1.34e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.03  E-value: 1.34e-03
                           10        20
                   ....*....|....*....|....*...
gi 49522946    105 YTVLHISVLRNQPEMVELLVQSGADINK 132
Cdd:smart00248   3 RTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 116-205 1.51e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 40.88  E-value: 1.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946  116 QPEMVELLVQSGADINKRDRIheSSPL-------DLASEESERLpcLQRLLELGADVNAADKNGKTALLHALASSDgvqI 188
Cdd:PHA02989  49 KIKIVKLLIDNGADVNYKGYI--ETPLcavlrnrEITSNKIKKI--VKLLLKFGADINLKTFNGVSPIVCFIYNSN---I 121

                         90
                 ....*....|....*..
gi 49522946  189 HNIENIRLLLEGGANVK 205
Cdd:PHA02989 122 NNCDMLRFLLSKGINVN 138
PHA02792 PHA02792
ankyrin-like protein; Provisional
 117-235 1.72e-03

ankyrin-like protein; Provisional


Pssm-ID: 165155 [Multi-domain]  Cd Length: 631  Bit Score: 40.70  E-value: 1.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946  117 PEMVELLVQSGADI-NKRDRIHESSPL--DLASEESERLPCLQRLLELGADVNAADKNGKTALLHALASsdgvqiHNIEN 193
Cdd:PHA02792 352 PKVVEYILKNGNVVvEDDDNIINIMPLfpTLSIHESDVLSILKLCKPYIDDINKIDKHGRSILYYCIES------HSVSL 425

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 49522946  194 IRLLLEGGANVKATTKdydTVFSCIIFLLGETMGCDQEEAKL 235
Cdd:PHA02792 426 VEWLIDNGADINITTK---YGSTCIGICVILAHACIPEIAEL 464
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 93-204 1.86e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 40.43  E-value: 1.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49522946   93 GADLSFE---DPVTYYTVLHISVLRNQPEMVELLVQSGADINKRDrIHESSPLDLASEESERlPCLQRLLELGADVNAAD 169
Cdd:PHA02876 131 GNDIHYDkinESIEYMKLIKERIQQDELLIAEMLLEGGADVNAKD-IYCITPIHYAAERGNA-KMVNLLLSYGADVNIIA 208

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 49522946  170 KNGKTALLHALASSdgvqihNIENIRLLLEGGANV 204
Cdd:PHA02876 209 LDDLSVLECAVDSK------NIDTIKAIIDNRSNI 237
Ank_5 pfam13857
Ankyrin repeats (many copies);
105-145 3.04e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.79  E-value: 3.04e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 49522946   105 YTVLHISVLRNQPEMVELLVQSGADINKRDRiHESSPLDLA 145
Cdd:pfam13857  17 YTPLHVAAKYGALEIVRVLLAYGVDLNLKDE-EGLTALDLA 56
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 374-413 3.87e-03

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 34.96  E-value: 3.87e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 49522946    374 SPPTLKHLCRVFIRQRLQPWpvdvKVKALPLPDRLKWYLL 413
Cdd:smart00253   6 NVPSLQHLCRFTIRRCTRTD----QIKTLPLPPKLKDYLS 41
SOCS_WSB_SWIP cd03733
SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily ...
 376-412 3.88e-03

SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh), as well as, their isoforms WSB-2 and SWiP-2. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239702  Cd Length: 39  Bit Score: 35.09  E-value: 3.88e-03
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 49522946 376 PTLKHLCRVFIRQRLQPWpvdvKVKALPLPDRLKWYL 412
Cdd:cd03733   4 SSLQHLCRMALRRVMTTQ----QVLALPIPKKMKEFL 36
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 140-170 5.37e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.57  E-value: 5.37e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 49522946   140 SPLDLASEESERLPCLQRLLELGADVNAADK 170
Cdd:pfam00023   4 TPLHLAAGRRGNLEIVKLLLSKGADVNARDK 34
SOCS_ASB13 cd03729
SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a ...
 374-415 5.58e-03

SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239699  Cd Length: 42  Bit Score: 34.76  E-value: 5.58e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 49522946 374 SPPTLKHLCRVFIRQRLQPWPVDVKVKaLPLPDRLKWYLLIN 415
Cdd:cd03729   2 TPLSLQQLCRINLRKALGTRALEKIAK-LNIPNRIIDYLSYN 42
SOCS_WSB2_SWIP2 cd03745
SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists ...
 376-412 5.77e-03

SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists of WSB-2 (SOCS-box-containing WD-40 protein) and SWiP-2 (SOCS box and WD-repeats in Protein). No functional information is available for WSB2 or SWiP-2, but limited information is available for the isoforms WSB-1 and SWiP-1. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239714  Cd Length: 39  Bit Score: 34.49  E-value: 5.77e-03
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 49522946 376 PTLKHLCRVFIRQRLQPWpvdvKVKALPLPDRLKWYL 412
Cdd:cd03745   4 PSLRHLCRKALRHFLTTY----QVLALPIPKKMKEFL 36
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 104-132 5.91e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 34.16  E-value: 5.91e-03
                          10        20
                  ....*....|....*....|....*....
gi 49522946   104 YYTVLHISVLRNQPEMVELLVQSGADINK 132
Cdd:pfam13606   2 GNTPLHLAARNGRLEIVKLLLENGADINA 30
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 158-215 6.80e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 38.73  E-value: 6.80e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 49522946  158 LLELGADVNAADKNGKTaLLHaLASSDGvqihNIENIRLLLEGGANVKATTKDYDTVF 215
Cdd:PTZ00322 101 LLTGGADPNCRDYDGRT-PLH-IACANG----HVQVVRVLLEFGADPTLLDKDGKTPL 152
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 374-413 8.40e-03

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 34.44  E-value: 8.40e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 49522946 374 SPPTLKHLCRVFIRQ-----RLQpwpVDVKVKALPLPDRLKWYLL 413
Cdd:cd03730   2 NPRSLKHLCRLKIRAcmgrlRLR---CPVFMSFLPLPNRLKAYIL 43
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 373-414 9.94e-03

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 33.95  E-value: 9.94e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 49522946 373 HSPPTLKHLCRVFIRQRLQPwPVDVKVKALPLPDRLKWYLLI 414
Cdd:cd03723   1 GTPRSLQHLCRCAIRKLLGS-RCHKLVPQLSLPTSLKNYLLL 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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