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Conserved domains on  [gi|37589461|gb|AAH59016|]
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Ltbp4 protein, partial [Mus musculus]

Protein Classification

calcium-binding EGF-like domain-containing protein; wall-associated receptor kinase family protein( domain architecture ID 11256465)

calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions| wall-associated receptor kinase (WAK) family protein containing the calcium-binding EGF and serine/threonine kinase domains but lacking the WAK galacturonan-binding domain, catalyzes the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates, and may function as a signaling receptor of extracellular matrix component

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 358-399 5.79e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 58.83  E-value: 5.79e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 37589461    358 CSLPILRNITKQICCCSRVGKAWGRGCQLCPPYGSEGFREIC 399
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
861-897 2.12e-07

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.40  E-value: 2.12e-07
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 37589461     861 DINECLEGDFCFPHGECLNTDGSFTCTCAPGYRPGPR 897
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTDGRN 37
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1343-1385 2.75e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.43  E-value: 2.75e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 37589461   1343 VCSRPrLDRQATYTECCCLY-GEAWGMDCALCPAQDSDDFEALC 1385
Cdd:pfam00683    2 RCSNP-LPGNVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1176-1218 5.58e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 47.66  E-value: 5.58e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 37589461   1176 CDNILARNVTWQECCC-TVGEGWGSGCriQQCPGTETAEYQSLC 1218
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPC--ELCPPPGTDEFRELC 44
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 818-850 1.03e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 1.03e-06
                         10        20        30
                 ....*....|....*....|....*....|...
gi 37589461  818 DVDECSSGTPCGLHGQCTNTKGSFHCSCSTGYR 850
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1032-1073 1.24e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 1.24e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 37589461    1032 DVDECRNRSFCGAHAMCQNLPGSFQCVCDQGYEgarDGRHCV 1073
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
903-938 8.00e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 8.00e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 37589461     903 DVDECSEEDLCQSG-ICTNTDGSFECICPPGHRAGPD 938
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 655-692 2.99e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 2.99e-05
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 37589461  655 DVDECtQSPGLCGR-GVCENLPGSFRCVCPAGFRGSACE 692
Cdd:cd00054    1 DIDEC-ASGNPCQNgGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
297-327 4.92e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 4.92e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 37589461     297 DVDECSTGGRCQHG-ECANTRGGYTCVCPDGF 327
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
736-777 1.52e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.52e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 37589461     736 DVDECSrSPSPCAYG-RCENTEGSFKCVCPTGFQPnaaGSECE 777
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
571-607 1.62e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 1.62e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 37589461     571 DIDECRRvPTPCAPG-RCENTPGSFRCVCGTGFQAGPR 607
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
613-654 3.34e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 3.34e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 37589461     613 DVDECRRvPPPCDRG-RCENTPGSFLCVCPAGYQAaphGASCQ 654
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1557-1591 1.18e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 1.18e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 37589461    1557 DVNECdeaeATSPLCVN-ARCVNTDGSFRCICRPGF 1591
Cdd:smart00179    1 DIDEC----ASGNPCQNgGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 694-728 1.62e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.62e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 37589461  694 DVDECAQQPPPCGPGRCDNTAGSFHCACPAGFRSR 728
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
944-982 2.00e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 2.00e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 37589461     944 DIDECRERGPALCGSqRCENSPGSYRCvrDCDPGYHPGP 982
Cdd:smart00179    1 DIDECASGNPCQNGG-TCVNTVGSYRC--ECPPGYTDGR 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1279-1308 2.18e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 2.18e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 37589461 1279 DNDECADEEPACEGGRCVNTVGSYHCTCEP 1308
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPP 30
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 553-574 9.19e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


:

Pssm-ID: 463661  Cd Length: 22  Bit Score: 35.08  E-value: 9.19e-03
                           10        20
                   ....*....|....*....|..
gi 37589461    553 TCACDPGFRLGPQGTRCIDIDE 574
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 358-399 5.79e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 58.83  E-value: 5.79e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 37589461    358 CSLPILRNITKQICCCSRVGKAWGRGCQLCPPYGSEGFREIC 399
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
861-897 2.12e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.40  E-value: 2.12e-07
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 37589461     861 DINECLEGDFCFPHGECLNTDGSFTCTCAPGYRPGPR 897
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTDGRN 37
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1343-1385 2.75e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.43  E-value: 2.75e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 37589461   1343 VCSRPrLDRQATYTECCCLY-GEAWGMDCALCPAQDSDDFEALC 1385
Cdd:pfam00683    2 RCSNP-LPGNVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1176-1218 5.58e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 47.66  E-value: 5.58e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 37589461   1176 CDNILARNVTWQECCC-TVGEGWGSGCriQQCPGTETAEYQSLC 1218
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPC--ELCPPPGTDEFRELC 44
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 818-850 1.03e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 1.03e-06
                         10        20        30
                 ....*....|....*....|....*....|...
gi 37589461  818 DVDECSSGTPCGLHGQCTNTKGSFHCSCSTGYR 850
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1032-1073 1.24e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 1.24e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 37589461    1032 DVDECRNRSFCGAHAMCQNLPGSFQCVCDQGYEgarDGRHCV 1073
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
818-850 2.69e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 2.69e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 37589461     818 DVDECSSGTPCGLHGQCTNTKGSFHCSCSTGYR 850
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 861-893 3.07e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 3.07e-06
                         10        20        30
                 ....*....|....*....|....*....|...
gi 37589461  861 DINECLEGDFCFPHGECLNTDGSFTCTCAPGYR 893
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
903-938 8.00e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 8.00e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 37589461     903 DVDECSEEDLCQSG-ICTNTDGSFECICPPGHRAGPD 938
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1032-1067 8.11e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 8.11e-06
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 37589461 1032 DVDECRNRSFCGAHAMCQNLPGSFQCVCDQGYEGAR 1067
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 655-692 2.99e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 2.99e-05
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 37589461  655 DVDECtQSPGLCGR-GVCENLPGSFRCVCPAGFRGSACE 692
Cdd:cd00054    1 DIDEC-ASGNPCQNgGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
297-327 4.92e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 4.92e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 37589461     297 DVDECSTGGRCQHG-ECANTRGGYTCVCPDGF 327
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 903-934 7.39e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 7.39e-05
                         10        20        30
                 ....*....|....*....|....*....|...
gi 37589461  903 DVDECSEEDLCQ-SGICTNTDGSFECICPPGHR 934
Cdd:cd00054    1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
655-692 1.24e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.24e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 37589461     655 DVDECtQSPGLCGRG-VCENLPGSFRCVCPAGFR-GSACE 692
Cdd:smart00179    1 DIDEC-ASGNPCQNGgTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
736-777 1.52e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.52e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 37589461     736 DVDECSrSPSPCAYG-RCENTEGSFKCVCPTGFQPnaaGSECE 777
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
571-607 1.62e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 1.62e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 37589461     571 DIDECRRvPTPCAPG-RCENTPGSFRCVCGTGFQAGPR 607
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 297-331 1.64e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.64e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 37589461  297 DVDECSTGGRCQ-HGECANTRGGYTCVCPDGFLLDS 331
Cdd:cd00054    1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
613-654 3.34e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 3.34e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 37589461     613 DVDECRRvPPPCDRG-RCENTPGSFLCVCPAGYQAaphGASCQ 654
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
903-932 9.46e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 9.46e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 37589461    903 DVDEC-SEEDLC-QSGICTNTDGSFECICPPG 932
Cdd:pfam07645    1 DVDECaTGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 613-654 9.81e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 9.81e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 37589461  613 DVDECRRVPPPCDRGRCENTPGSFLCVCPAGYqaapHGASCQ 654
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGY----TGRNCE 38
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1042-1072 1.00e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 37.96  E-value: 1.00e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 37589461   1042 CGAHAMCQNLPGSFQCVCDQGYEGarDGRHC 1072
Cdd:pfam12947    8 CHPNATCTNTGGSFTCTCNDGYTG--DGVTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 736-768 1.11e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.11e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 37589461  736 DVDECSrSPSPCAY-GRCENTEGSFKCVCPTGFQ 768
Cdd:cd00054    1 DIDECA-SGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1557-1591 1.18e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 1.18e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 37589461    1557 DVNECdeaeATSPLCVN-ARCVNTDGSFRCICRPGF 1591
Cdd:smart00179    1 DIDEC----ASGNPCQNgGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 694-728 1.62e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.62e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 37589461  694 DVDECAQQPPPCGPGRCDNTAGSFHCACPAGFRSR 728
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
694-728 1.89e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 1.89e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 37589461     694 DVDECAQqPPPCGPG-RCDNTAGSFHCACPAGFRSR 728
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTDG 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
944-982 2.00e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 2.00e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 37589461     944 DIDECRERGPALCGSqRCENSPGSYRCvrDCDPGYHPGP 982
Cdd:smart00179    1 DIDECASGNPCQNGG-TCVNTVGSYRC--ECPPGYTDGR 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1279-1308 2.18e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 2.18e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 37589461 1279 DNDECADEEPACEGGRCVNTVGSYHCTCEP 1308
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPP 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
1279-1308 2.37e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 2.37e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 37589461    1279 DNDECADEEPACEGGRCVNTVGSYHCTCEP 1308
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPP 30
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 822-850 3.60e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 36.42  E-value: 3.60e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 37589461    822 CSSGT-PCGLHGQCTNTKGSFHCSCSTGYR 850
Cdd:pfam12947    1 CSDNNgGCHPNATCTNTGGSFTCTCNDGYT 30
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1557-1595 3.67e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 3.67e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 37589461 1557 DVNECDEAeatSPLCVNARCVNTDGSFRCICRPGFAPTH 1595
Cdd:cd00054    1 DIDECASG---NPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA pfam07645
Calcium-binding EGF domain;
655-685 3.82e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 3.82e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 37589461    655 DVDECTQSPGLCGR-GVCENLPGSFRCVCPAG 685
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1557-1590 4.61e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 4.61e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 37589461   1557 DVNECDEAEATSPlcVNARCVNTDGSFRCICRPG 1590
Cdd:pfam07645    1 DVDECATGTHNCP--ANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 571-603 5.44e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 5.44e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 37589461  571 DIDECRRvPTPCAP-GRCENTPGSFRCVCGTGFQ 603
Cdd:cd00054    1 DIDECAS-GNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
613-643 5.67e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 5.67e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 37589461    613 DVDECRRVPPPCDR-GRCENTPGSFLCVCPAG 643
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
736-766 9.09e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.29  E-value: 9.09e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 37589461    736 DVDECSRSPSPCAY-GRCENTEGSFKCVCPTG 766
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 553-574 9.19e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 35.08  E-value: 9.19e-03
                           10        20
                   ....*....|....*....|..
gi 37589461    553 TCACDPGFRLGPQGTRCIDIDE 574
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 358-399 5.79e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 58.83  E-value: 5.79e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 37589461    358 CSLPILRNITKQICCCSRVGKAWGRGCQLCPPYGSEGFREIC 399
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
861-897 2.12e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.40  E-value: 2.12e-07
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 37589461     861 DINECLEGDFCFPHGECLNTDGSFTCTCAPGYRPGPR 897
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTDGRN 37
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1343-1385 2.75e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.43  E-value: 2.75e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 37589461   1343 VCSRPrLDRQATYTECCCLY-GEAWGMDCALCPAQDSDDFEALC 1385
Cdd:pfam00683    2 RCSNP-LPGNVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1176-1218 5.58e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 47.66  E-value: 5.58e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 37589461   1176 CDNILARNVTWQECCC-TVGEGWGSGCriQQCPGTETAEYQSLC 1218
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPC--ELCPPPGTDEFRELC 44
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 818-850 1.03e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 1.03e-06
                         10        20        30
                 ....*....|....*....|....*....|...
gi 37589461  818 DVDECSSGTPCGLHGQCTNTKGSFHCSCSTGYR 850
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1032-1073 1.24e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 1.24e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 37589461    1032 DVDECRNRSFCGAHAMCQNLPGSFQCVCDQGYEgarDGRHCV 1073
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
818-850 2.69e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 2.69e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 37589461     818 DVDECSSGTPCGLHGQCTNTKGSFHCSCSTGYR 850
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 861-893 3.07e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 3.07e-06
                         10        20        30
                 ....*....|....*....|....*....|...
gi 37589461  861 DINECLEGDFCFPHGECLNTDGSFTCTCAPGYR 893
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
903-938 8.00e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 8.00e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 37589461     903 DVDECSEEDLCQSG-ICTNTDGSFECICPPGHRAGPD 938
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1032-1067 8.11e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 8.11e-06
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 37589461 1032 DVDECRNRSFCGAHAMCQNLPGSFQCVCDQGYEGAR 1067
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 655-692 2.99e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 2.99e-05
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 37589461  655 DVDECtQSPGLCGR-GVCENLPGSFRCVCPAGFRGSACE 692
Cdd:cd00054    1 DIDEC-ASGNPCQNgGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
297-327 4.92e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 4.92e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 37589461     297 DVDECSTGGRCQHG-ECANTRGGYTCVCPDGF 327
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 903-934 7.39e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 7.39e-05
                         10        20        30
                 ....*....|....*....|....*....|...
gi 37589461  903 DVDECSEEDLCQ-SGICTNTDGSFECICPPGHR 934
Cdd:cd00054    1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
655-692 1.24e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.24e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 37589461     655 DVDECtQSPGLCGRG-VCENLPGSFRCVCPAGFR-GSACE 692
Cdd:smart00179    1 DIDEC-ASGNPCQNGgTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
736-777 1.52e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.52e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 37589461     736 DVDECSrSPSPCAYG-RCENTEGSFKCVCPTGFQPnaaGSECE 777
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
571-607 1.62e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 1.62e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 37589461     571 DIDECRRvPTPCAPG-RCENTPGSFRCVCGTGFQAGPR 607
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 297-331 1.64e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.64e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 37589461  297 DVDECSTGGRCQ-HGECANTRGGYTCVCPDGFLLDS 331
Cdd:cd00054    1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
613-654 3.34e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 3.34e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 37589461     613 DVDECRRvPPPCDRG-RCENTPGSFLCVCPAGYQAaphGASCQ 654
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
903-932 9.46e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 9.46e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 37589461    903 DVDEC-SEEDLC-QSGICTNTDGSFECICPPG 932
Cdd:pfam07645    1 DVDECaTGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 613-654 9.81e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 9.81e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 37589461  613 DVDECRRVPPPCDRGRCENTPGSFLCVCPAGYqaapHGASCQ 654
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGY----TGRNCE 38
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1042-1072 1.00e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 37.96  E-value: 1.00e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 37589461   1042 CGAHAMCQNLPGSFQCVCDQGYEGarDGRHC 1072
Cdd:pfam12947    8 CHPNATCTNTGGSFTCTCNDGYTG--DGVTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 736-768 1.11e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.11e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 37589461  736 DVDECSrSPSPCAY-GRCENTEGSFKCVCPTGFQ 768
Cdd:cd00054    1 DIDECA-SGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1557-1591 1.18e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 1.18e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 37589461    1557 DVNECdeaeATSPLCVN-ARCVNTDGSFRCICRPGF 1591
Cdd:smart00179    1 DIDEC----ASGNPCQNgGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 694-728 1.62e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.62e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 37589461  694 DVDECAQQPPPCGPGRCDNTAGSFHCACPAGFRSR 728
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
694-728 1.89e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 1.89e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 37589461     694 DVDECAQqPPPCGPG-RCDNTAGSFHCACPAGFRSR 728
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTDG 35
EGF smart00181
Epidermal growth factor-like domain;
300-332 1.89e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 37.50  E-value: 1.89e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 37589461     300 ECSTGGRCQHGECANTRGGYTCVCPDGFLLDSS 332
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYTGDKR 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
944-982 2.00e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 2.00e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 37589461     944 DIDECRERGPALCGSqRCENSPGSYRCvrDCDPGYHPGP 982
Cdd:smart00179    1 DIDECASGNPCQNGG-TCVNTVGSYRC--ECPPGYTDGR 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1279-1308 2.18e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 2.18e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 37589461 1279 DNDECADEEPACEGGRCVNTVGSYHCTCEP 1308
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPP 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
1279-1308 2.37e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 2.37e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 37589461    1279 DNDECADEEPACEGGRCVNTVGSYHCTCEP 1308
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPP 30
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 822-850 3.60e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 36.42  E-value: 3.60e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 37589461    822 CSSGT-PCGLHGQCTNTKGSFHCSCSTGYR 850
Cdd:pfam12947    1 CSDNNgGCHPNATCTNTGGSFTCTCNDGYT 30
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1557-1595 3.67e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 3.67e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 37589461 1557 DVNECDEAeatSPLCVNARCVNTDGSFRCICRPGFAPTH 1595
Cdd:cd00054    1 DIDECASG---NPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA pfam07645
Calcium-binding EGF domain;
655-685 3.82e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 3.82e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 37589461    655 DVDECTQSPGLCGR-GVCENLPGSFRCVCPAG 685
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1557-1590 4.61e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 4.61e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 37589461   1557 DVNECDEAEATSPlcVNARCVNTDGSFRCICRPG 1590
Cdd:pfam07645    1 DVDECATGTHNCP--ANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 571-603 5.44e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 5.44e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 37589461  571 DIDECRRvPTPCAP-GRCENTPGSFRCVCGTGFQ 603
Cdd:cd00054    1 DIDECAS-GNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
613-643 5.67e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 5.67e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 37589461    613 DVDECRRVPPPCDR-GRCENTPGSFLCVCPAG 643
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
736-766 9.09e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.29  E-value: 9.09e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 37589461    736 DVDECSRSPSPCAY-GRCENTEGSFKCVCPTG 766
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 553-574 9.19e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 35.08  E-value: 9.19e-03
                           10        20
                   ....*....|....*....|..
gi 37589461    553 TCACDPGFRLGPQGTRCIDIDE 574
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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