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Conserved domains on  [gi|34785797|gb|AAH57506|]
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Zgc:85866 protein, partial [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 248-291 2.04e-16

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


:

Pssm-ID: 465952  Cd Length: 44  Bit Score: 72.37  E-value: 2.04e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 34785797   248 CIVQTTGWSQCSRSCGTGISTRITNNNAECKLMKESRICEVRPC 291
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNAECKLVTETRLCQLRPC 44
GHB_like super family cl21545
Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the ...
 302-396 1.24e-10

Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the beta chains of gonadotropins, thyrotropins, follitropins, choriogonadotropins and more. The members are reproductive hormones that consist of two glycosylated chains (alpha and beta), which form a tightly bound dimer.


The actual alignment was detected with superfamily member pfam00007:

Pssm-ID: 473907  Cd Length: 105  Bit Score: 58.19  E-value: 1.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34785797   302 GKKCNRTKKsvmPVKFSYAGCSSLKKYRPRFC-GSCV-------DGR-------CCSPQNTRTIRVKFRCQDGETFNKNV 366
Cdd:pfam00007   1 RKKCIPTNY---TISVEKEGCTSCKTINTTICaGYCYtrdpvykDGRravsqrvCTYRDVTYETVVLPGCPPGVDPTVTY 77

                          90       100       110
                  ....*....|....*....|....*....|
gi 34785797   367 MMIESCKCTKhCPHASEAgFPFYRLYNDIH 396
Cdd:pfam00007  78 PVALSCHCGN-CPTDNSD-CTRLSLQPDSC 105
VWC smart00214
von Willebrand factor (vWF) type C domain;
126-185 4.12e-09

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214564  Cd Length: 59  Bit Score: 52.13  E-value: 4.12e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 34785797    126 CEYSSRIYQNGESFQPNCKHQCTCMDGA-VGCVPL-CPqelslPALGCANPRLAKVPGRCCE 185
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVeCP-----PPPDCPNPERVKPPGECCP 57
IGFBP pfam00219
Insulin-like growth factor binding protein;
60-104 5.46e-07

Insulin-like growth factor binding protein;


:

Pssm-ID: 459717  Cd Length: 53  Bit Score: 46.16  E-value: 5.46e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 34785797    60 CPAVCS---CAPDAPQ------RDACGCCLVCARQLNEDCS-RSEPCDhsKGLEC 104
Cdd:pfam00219   1 CPPPCDperCPPPPPGcpagvvLDGCGCCKVCARQEGEPCGvYTPPCG--KGLRC 53
 
Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 248-291 2.04e-16

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


Pssm-ID: 465952  Cd Length: 44  Bit Score: 72.37  E-value: 2.04e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 34785797   248 CIVQTTGWSQCSRSCGTGISTRITNNNAECKLMKESRICEVRPC 291
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNAECKLVTETRLCQLRPC 44
Cys_knot pfam00007
Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of ...
 302-396 1.24e-10

Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.


Pssm-ID: 394966  Cd Length: 105  Bit Score: 58.19  E-value: 1.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34785797   302 GKKCNRTKKsvmPVKFSYAGCSSLKKYRPRFC-GSCV-------DGR-------CCSPQNTRTIRVKFRCQDGETFNKNV 366
Cdd:pfam00007   1 RKKCIPTNY---TISVEKEGCTSCKTINTTICaGYCYtrdpvykDGRravsqrvCTYRDVTYETVVLPGCPPGVDPTVTY 77

                          90       100       110
                  ....*....|....*....|....*....|
gi 34785797   367 MMIESCKCTKhCPHASEAgFPFYRLYNDIH 396
Cdd:pfam00007  78 PVALSCHCGN-CPTDNSD-CTRLSLQPDSC 105
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 310-379 1.44e-10

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 57.03  E-value: 1.44e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34785797    310 KSVMPVKFSYAGCSSlKKYRPRFC-GSCVD------------GRCCSPQNTRTIRVKFRCQDGETFNKNVMMIESCKCTK 376
Cdd:smart00041   1 KSPVRQTITYNGCTS-VTVKNAFCeGKCGSassysiqdvqhsCSCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEP 79


                   ...
gi 34785797    377 HCP 379
Cdd:smart00041  80 NCP 82
VWC smart00214
von Willebrand factor (vWF) type C domain;
126-185 4.12e-09

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 52.13  E-value: 4.12e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 34785797    126 CEYSSRIYQNGESFQPNCKHQCTCMDGA-VGCVPL-CPqelslPALGCANPRLAKVPGRCCE 185
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVeCP-----PPPDCPNPERVKPPGECCP 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 126-186 2.28e-07

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 47.42  E-value: 2.28e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 34785797   126 CEYSSRIYQNGESFQPNCKHQCTCMDGAVGCVPlcpqeLSLPALGCANPRLAKVPGRCCEE 186
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDK-----IICPPLDCPNPRLEIPPGECCPV 56
IGFBP pfam00219
Insulin-like growth factor binding protein;
60-104 5.46e-07

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 46.16  E-value: 5.46e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 34785797    60 CPAVCS---CAPDAPQ------RDACGCCLVCARQLNEDCS-RSEPCDhsKGLEC 104
Cdd:pfam00219   1 CPPPCDperCPPPPPGcpagvvLDGCGCCKVCARQEGEPCGvYTPPCG--KGLRC 53
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 60-108 9.59e-05

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 40.53  E-value: 9.59e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 34785797     60 CPAVCS--CAPDAPQ------RDACGCCLVCARQLNEDCS-RSEPCdhSKGLECNYGA 108
Cdd:smart00121   3 CPPCDParCPPCPPGcaelvrLDGCGCCPVCARQEGEPCGvYTPRC--APGLRCQPPP 58
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 255-292 8.26e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 34.48  E-value: 8.26e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 34785797    255 WSQCSRSCGTGISTRI--------TNNNAECK-LMKESRICEVRPCS 292
Cdd:smart00209   7 WSPCSVTCGGGVQTRTrsccspppQNGGGPCTgEDVETRACNEQPCP 53
 
Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 248-291 2.04e-16

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


Pssm-ID: 465952  Cd Length: 44  Bit Score: 72.37  E-value: 2.04e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 34785797   248 CIVQTTGWSQCSRSCGTGISTRITNNNAECKLMKESRICEVRPC 291
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNAECKLVTETRLCQLRPC 44
Cys_knot pfam00007
Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of ...
 302-396 1.24e-10

Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.


Pssm-ID: 394966  Cd Length: 105  Bit Score: 58.19  E-value: 1.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34785797   302 GKKCNRTKKsvmPVKFSYAGCSSLKKYRPRFC-GSCV-------DGR-------CCSPQNTRTIRVKFRCQDGETFNKNV 366
Cdd:pfam00007   1 RKKCIPTNY---TISVEKEGCTSCKTINTTICaGYCYtrdpvykDGRravsqrvCTYRDVTYETVVLPGCPPGVDPTVTY 77

                          90       100       110
                  ....*....|....*....|....*....|
gi 34785797   367 MMIESCKCTKhCPHASEAgFPFYRLYNDIH 396
Cdd:pfam00007  78 PVALSCHCGN-CPTDNSD-CTRLSLQPDSC 105
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 310-379 1.44e-10

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 57.03  E-value: 1.44e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34785797    310 KSVMPVKFSYAGCSSlKKYRPRFC-GSCVD------------GRCCSPQNTRTIRVKFRCQDGETFNKNVMMIESCKCTK 376
Cdd:smart00041   1 KSPVRQTITYNGCTS-VTVKNAFCeGKCGSassysiqdvqhsCSCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEP 79


                   ...
gi 34785797    377 HCP 379
Cdd:smart00041  80 NCP 82
VWC smart00214
von Willebrand factor (vWF) type C domain;
126-185 4.12e-09

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 52.13  E-value: 4.12e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 34785797    126 CEYSSRIYQNGESFQPNCKHQCTCMDGA-VGCVPL-CPqelslPALGCANPRLAKVPGRCCE 185
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVeCP-----PPPDCPNPERVKPPGECCP 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 126-186 2.28e-07

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 47.42  E-value: 2.28e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 34785797   126 CEYSSRIYQNGESFQPNCKHQCTCMDGAVGCVPlcpqeLSLPALGCANPRLAKVPGRCCEE 186
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDK-----IICPPLDCPNPRLEIPPGECCPV 56
IGFBP pfam00219
Insulin-like growth factor binding protein;
60-104 5.46e-07

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 46.16  E-value: 5.46e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 34785797    60 CPAVCS---CAPDAPQ------RDACGCCLVCARQLNEDCS-RSEPCDhsKGLEC 104
Cdd:pfam00219   1 CPPPCDperCPPPPPGcpagvvLDGCGCCKVCARQEGEPCGvYTPPCG--KGLRC 53
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 60-108 9.59e-05

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 40.53  E-value: 9.59e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 34785797     60 CPAVCS--CAPDAPQ------RDACGCCLVCARQLNEDCS-RSEPCdhSKGLECNYGA 108
Cdd:smart00121   3 CPPCDParCPPCPPGcaelvrLDGCGCCPVCARQEGEPCGvYTPRC--APGLRCQPPP 58
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 253-291 1.19e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 36.49  E-value: 1.19e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 34785797   253 TGWSQCSRSCGTGISTRI-------TNNNAECKLMKESRICEVRPC 291
Cdd:pfam19028   7 SEWSECSVTCGGGVQTRTrtvivepQNGGRPCPELLERRPCNLPPC 52
Sclerostin pfam05463
Sclerostin (SOST); This family contains several mammalian sclerostin (SOST) proteins. SOST is ...
 342-377 5.15e-03

Sclerostin (SOST); This family contains several mammalian sclerostin (SOST) proteins. SOST is thought to suppress bone formation. Mutations of the SOST gene lead to sclerosteosis, a progressive sclerosing bone dysplasia with an autosomal recessive mode of inheritance. Radiologically, it is characterized by a generalized hyperostosis and sclerosis leading to a markedly thickened and sclerotic skull, with mandible, ribs, clavicles and all long bones also being affected. Due to narrowing of the foramina of the cranial nerves, facial nerve palsy, hearing loss and atrophy of the optic nerves can occur. Sclerosteosis is clinically and radiologically very similar to van Buchem disease, mainly differentiated by hand malformations and a large stature in sclerosteosis patients.


Pssm-ID: 398883  Cd Length: 198  Bit Score: 37.97  E-value: 5.15e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 34785797   342 CSPQNTRTIRVKFRCQDGETFNKNVMMIESCKCTKH 377
Cdd:pfam05463 123 CVNDRTRTQRIQLQCQDGTTRTYKVTVVTSCKCKRY 158
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 255-292 8.26e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 34.48  E-value: 8.26e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 34785797    255 WSQCSRSCGTGISTRI--------TNNNAECK-LMKESRICEVRPCS 292
Cdd:smart00209   7 WSPCSVTCGGGVQTRTrsccspppQNGGGPCTgEDVETRACNEQPCP 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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