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Conserved domains on  [gi|33585440|gb|AAH55429|]
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Junctophilin 4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
4-143 2.02e-24

Uncharacterized conserved protein [Function unknown];


:

Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 103.11  E-value: 2.02e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33585440   4 GGKFDFDDGGCYVGGWEAGRAHGYGVCTGPGAqGEYSGCWAHG-FESLGVFTGPGGHSYQGHWQQGKREGLGVER-KSRW 81
Cdd:COG4642 116 GGVLEGDDGGGYGGGTADGGRGGGGIYTFPNG-DVYEGEFKNGkPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTyANGD 194

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 33585440  82 TYRGEWLGGLKGRSGVWESVSGLRYAGLWKDGFQDGYGTETYSDGGTYQGQWQAGKRHGYGV 143
Cdd:COG4642 195 VYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGT 256
COG4642 super family cl34799
Uncharacterized conserved protein [Function unknown];
281-336 6.97e-10

Uncharacterized conserved protein [Function unknown];


The actual alignment was detected with superfamily member COG4642:

Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 60.36  E-value: 6.97e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 33585440 281 VYAGEWRADRRSGFGVSQRSNGLRYEGEWLGNQRHGYGRTTRPDGSREEGKYKRNR 336
Cdd:COG4642 149 VYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQ 204
PRK07003 super family cl35530
DNA polymerase III subunit gamma/tau;
369-606 9.70e-06

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK07003:

Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 48.69  E-value: 9.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33585440  369 RAVSAARQRQEIAAARAADALLKAVAASSVAEKAVEAARMAKLIAQDLQPMLEAPGR-RPRQDSEGSDTEPLDEDSPGVY 447
Cdd:PRK07003 378 GAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPAtADRGDDAADGDAPVPAKANARA 457

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33585440  448 ENGLTPSEGSPELPSSPASSRQPW---RPPACRSPLPPGGDQGPFSSPKAwpeewggagAQAEELAGYEAEDEAGMQG-P 523
Cdd:PRK07003 458 SADSRCDERDAQPPADSGSASAPAsdaPPDAAFEPAPRAAAPSAATPAAV---------PDARAPAAASREDAPAAAApP 528

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33585440  524 GPRDGSPllggcSDSSGSLREEEGEDEEPLPPLRApAGtepepiamlvLRGSSSRGHDAGCLTEELGEPAATERPAQPGA 603
Cdd:PRK07003 529 APEARPP-----TPAAAAPAARAGGAAAALDVLRN-AG----------MRVSSDRGARAAAAAKPAAAPAAAPKPAAPRV 592


                 ...
gi 33585440  604 ANP 606
Cdd:PRK07003 593 AVQ 595
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
4-143 2.02e-24

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 103.11  E-value: 2.02e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33585440   4 GGKFDFDDGGCYVGGWEAGRAHGYGVCTGPGAqGEYSGCWAHG-FESLGVFTGPGGHSYQGHWQQGKREGLGVER-KSRW 81
Cdd:COG4642 116 GGVLEGDDGGGYGGGTADGGRGGGGIYTFPNG-DVYEGEFKNGkPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTyANGD 194

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 33585440  82 TYRGEWLGGLKGRSGVWESVSGLRYAGLWKDGFQDGYGTETYSDGGTYQGQWQAGKRHGYGV 143
Cdd:COG4642 195 VYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGT 256
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 5-143 2.82e-20

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 95.29  E-value: 2.82e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33585440    5 GKFDFDDGGCYVGGWEAGRAHGYGVCTGP-GA--QGEYSGCWAHGFeslGVFTGPGGHSYQGHWQQGKREGLGVER---- 77
Cdd:PLN03185  24 GKYLWSDGCMYEGEWRRGMRHGNGKISWPsGAtyEGEFSGGYMHGS---GTYTGTDGTTYKGRWRLNLKHGLGYQRypng 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33585440   78 ----------------KSRW----TYRGEWLGGLKGRSGVWESVSGLRYAGLWKDGFQDGYGTETYSDGGTYQGQWQAGK 137
Cdd:PLN03185 101 dvfegswiqglqegpgKYTWangnVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMMHGFGVYTWSDGGCYVGTWTRGL 180


                 ....*.
gi 33585440  138 RHGYGV 143
Cdd:PLN03185 181 KDGKGV 186
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
281-336 6.97e-10

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 60.36  E-value: 6.97e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 33585440 281 VYAGEWRADRRSGFGVSQRSNGLRYEGEWLGNQRHGYGRTTRPDGSREEGKYKRNR 336
Cdd:COG4642 149 VYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQ 204
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
369-606 9.70e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 48.69  E-value: 9.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33585440  369 RAVSAARQRQEIAAARAADALLKAVAASSVAEKAVEAARMAKLIAQDLQPMLEAPGR-RPRQDSEGSDTEPLDEDSPGVY 447
Cdd:PRK07003 378 GAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPAtADRGDDAADGDAPVPAKANARA 457

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33585440  448 ENGLTPSEGSPELPSSPASSRQPW---RPPACRSPLPPGGDQGPFSSPKAwpeewggagAQAEELAGYEAEDEAGMQG-P 523
Cdd:PRK07003 458 SADSRCDERDAQPPADSGSASAPAsdaPPDAAFEPAPRAAAPSAATPAAV---------PDARAPAAASREDAPAAAApP 528

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33585440  524 GPRDGSPllggcSDSSGSLREEEGEDEEPLPPLRApAGtepepiamlvLRGSSSRGHDAGCLTEELGEPAATERPAQPGA 603
Cdd:PRK07003 529 APEARPP-----TPAAAAPAARAGGAAAALDVLRN-AG----------MRVSSDRGARAAAAAKPAAAPAAAPKPAAPRV 592


                 ...
gi 33585440  604 ANP 606
Cdd:PRK07003 593 AVQ 595
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 281-340 2.26e-05

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 47.52  E-value: 2.26e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 33585440  281 VYAGEWRADRRSGFGVSQRSNGLRYEGEWLGNQRHGYGRTTRPDGSREEGKYKRNrLVHG 340
Cdd:PLN03185  33 MYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLN-LKHG 91
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 305-327 1.31e-03

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 36.23  E-value: 1.31e-03
                          10        20
                  ....*....|....*....|...
gi 33585440   305 YEGEWLGNQRHGYGRTTRPDGSR 327
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
304-324 1.47e-03

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 36.16  E-value: 1.47e-03
                           10        20
                   ....*....|....*....|.
gi 33585440    304 RYEGEWLGNQRHGYGRTTRPD 324
Cdd:smart00698   2 RYEGEWRNGKRHGRGVYTYAN 22
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
128-143 3.86e-03

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 35.01  E-value: 3.86e-03
                           10
                   ....*....|....*.
gi 33585440    128 TYQGQWQAGKRHGYGV 143
Cdd:smart00698   2 RYEGEWRNGKRHGRGV 17
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
4-143 2.02e-24

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 103.11  E-value: 2.02e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33585440   4 GGKFDFDDGGCYVGGWEAGRAHGYGVCTGPGAqGEYSGCWAHG-FESLGVFTGPGGHSYQGHWQQGKREGLGVER-KSRW 81
Cdd:COG4642 116 GGVLEGDDGGGYGGGTADGGRGGGGIYTFPNG-DVYEGEFKNGkPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTyANGD 194

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 33585440  82 TYRGEWLGGLKGRSGVWESVSGLRYAGLWKDGFQDGYGTETYSDGGTYQGQWQAGKRHGYGV 143
Cdd:COG4642 195 VYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGT 256
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
4-143 8.82e-22

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 95.41  E-value: 8.82e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33585440   4 GGKFDFDDGGCYVGGWEAGRAHGYGVCTGPGAQGEYSGCWAHGFESLGVFTGPGGHSYQGHWQQGKREGLGV-ERKSRWT 82
Cdd:COG4642  93 GGEGGFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTlTYADGDR 172

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 33585440  83 YRGEWLGGLKGRSGVWESVSGLRYAGLWKDGFQDGYGTETYSDGGTYQGQWQAGKRHGYGV 143
Cdd:COG4642 173 YEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGT 233
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 5-143 2.82e-20

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 95.29  E-value: 2.82e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33585440    5 GKFDFDDGGCYVGGWEAGRAHGYGVCTGP-GA--QGEYSGCWAHGFeslGVFTGPGGHSYQGHWQQGKREGLGVER---- 77
Cdd:PLN03185  24 GKYLWSDGCMYEGEWRRGMRHGNGKISWPsGAtyEGEFSGGYMHGS---GTYTGTDGTTYKGRWRLNLKHGLGYQRypng 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33585440   78 ----------------KSRW----TYRGEWLGGLKGRSGVWESVSGLRYAGLWKDGFQDGYGTETYSDGGTYQGQWQAGK 137
Cdd:PLN03185 101 dvfegswiqglqegpgKYTWangnVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMMHGFGVYTWSDGGCYVGTWTRGL 180


                 ....*.
gi 33585440  138 RHGYGV 143
Cdd:PLN03185 181 KDGKGV 186
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
4-133 2.11e-19

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 88.47  E-value: 2.11e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33585440   4 GGKFDFDDGGCYVGGWEAGRAHGYGVCTGPGaQGEYSGCWAHG-FESLGVFTGPGGHSYQGHWQQGKREGLGV-ERKSRW 81
Cdd:COG4642 139 GGIYTFPNGDVYEGEFKNGKPHGQGTLTYAD-GDRYEGEFKNGkRHGQGTLTYANGDVYEGEFKNGQRHGQGTyTYADGD 217

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 33585440  82 TYRGEWLGGLKGRSGVWESVSGLRYAGLWKDGFQDGYGTETYSDGGTYQGQW 133
Cdd:COG4642 218 RYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGTMTYADGSVYEGEW 269
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
10-333 5.19e-17

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 81.54  E-value: 5.19e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33585440  10 DDGGCYVGGWEAGRAHGYGVCTGPGAQGEYSGCWAHGFESLGVFTGPGGHSYQGHWQQGKREGLGVERK----------- 78
Cdd:COG4642  41 PGGGGYGGGADGGGGGGGGTGVAGGGGGEGGVTAAGGGGGGGGGKGDGGDGGGGEGGFGGGGGGGGGKKggggggggvle 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33585440  79 --SRWTYRGEWLGGLKGRSGVWESVSGLRYAGLWKDGFQDGYGTETYSDGGTYQGQWQAGKRHGYGVRQSvpyhqaallr 156
Cdd:COG4642 121 gdDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTY---------- 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33585440 157 sprrtsldsghsdpptpppplplpgdeggspASGSR--GGFVlagpgdadgassrkrtpaaggffrrslllSGLRAGgrr 234
Cdd:COG4642 191 -------------------------------ANGDVyeGEFK-----------------------------NGQRHG--- 207

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33585440 235 sslgskRGSLRSevssevgstgppgseASGppaaappaliegsatEVYAGEWRADRRSGFGVSQRSNGLRYEGEWLGNQR 314
Cdd:COG4642 208 ------QGTYTY---------------ADG---------------DRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKR 251

                       330
                ....*....|....*....
gi 33585440 315 HGYGRTTRPDGSREEGKYK 333
Cdd:COG4642 252 HGQGTMTYADGSVYEGEWK 270
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
281-336 6.97e-10

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 60.36  E-value: 6.97e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 33585440 281 VYAGEWRADRRSGFGVSQRSNGLRYEGEWLGNQRHGYGRTTRPDGSREEGKYKRNR 336
Cdd:COG4642 149 VYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQ 204
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 56-148 1.32e-08

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 57.92  E-value: 1.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33585440   56 PGGHSYQGHWQQGKREGLGverKSRW----TYRGEWLGGLKGRSGVWESVSGLRYAGLWKDGFQDGYGTETYSDGGTYQG 131
Cdd:PLN03185   6 SNGDFYSGSLLGNVPEGPG---KYLWsdgcMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKG 82

                         90
                 ....*....|....*..
gi 33585440  132 QWQAGKRHGYGvRQSVP 148
Cdd:PLN03185  83 RWRLNLKHGLG-YQRYP 98
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
275-340 1.13e-06

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 50.34  E-value: 1.13e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 33585440 275 EGSATEVYAGEWRADRRSGFGVSQRSNGLRYEGEWLGNQRHGYGRTTRPDGSREEGKYKRNRLvHG 340
Cdd:COG4642 120 EGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKR-HG 184
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
369-606 9.70e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 48.69  E-value: 9.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33585440  369 RAVSAARQRQEIAAARAADALLKAVAASSVAEKAVEAARMAKLIAQDLQPMLEAPGR-RPRQDSEGSDTEPLDEDSPGVY 447
Cdd:PRK07003 378 GAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPAtADRGDDAADGDAPVPAKANARA 457

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33585440  448 ENGLTPSEGSPELPSSPASSRQPW---RPPACRSPLPPGGDQGPFSSPKAwpeewggagAQAEELAGYEAEDEAGMQG-P 523
Cdd:PRK07003 458 SADSRCDERDAQPPADSGSASAPAsdaPPDAAFEPAPRAAAPSAATPAAV---------PDARAPAAASREDAPAAAApP 528

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33585440  524 GPRDGSPllggcSDSSGSLREEEGEDEEPLPPLRApAGtepepiamlvLRGSSSRGHDAGCLTEELGEPAATERPAQPGA 603
Cdd:PRK07003 529 APEARPP-----TPAAAAPAARAGGAAAALDVLRN-AG----------MRVSSDRGARAAAAAKPAAAPAAAPKPAAPRV 592


                 ...
gi 33585440  604 ANP 606
Cdd:PRK07003 593 AVQ 595
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 281-340 2.26e-05

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 47.52  E-value: 2.26e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 33585440  281 VYAGEWRADRRSGFGVSQRSNGLRYEGEWLGNQRHGYGRTTRPDGSREEGKYKRNrLVHG 340
Cdd:PLN03185  33 MYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLN-LKHG 91
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 305-327 1.31e-03

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 36.23  E-value: 1.31e-03
                          10        20
                  ....*....|....*....|...
gi 33585440   305 YEGEWLGNQRHGYGRTTRPDGSR 327
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
304-324 1.47e-03

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 36.16  E-value: 1.47e-03
                           10        20
                   ....*....|....*....|.
gi 33585440    304 RYEGEWLGNQRHGYGRTTRPD 324
Cdd:smart00698   2 RYEGEWRNGKRHGRGVYTYAN 22
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
5-67 2.63e-03

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 39.94  E-value: 2.63e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 33585440   5 GKFDFDDGGCYVGGWEAGRAHGYGVCTGpgAQGE-YSGCWAHG-FESLGVFTGPGGHSYQGHWQQ 67
Cdd:COG4642 209 GTYTYADGDRYEGEFKNGKRHGQGTLTY--ADGDrYEGEFKNGkRHGQGTMTYADGSVYEGEWKN 271
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 280-332 3.53e-03

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 40.59  E-value: 3.53e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 33585440  280 EVYAGEWRADRRSGFGVSQRSNGLRYEGEWLGNQRHGYGRTTRPDGSREEGKY 332
Cdd:PLN03185   9 DFYSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEF 61
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
128-143 3.86e-03

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 35.01  E-value: 3.86e-03
                           10
                   ....*....|....*.
gi 33585440    128 TYQGQWQAGKRHGYGV 143
Cdd:smart00698   2 RYEGEWRNGKRHGRGV 17
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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