Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 30851203 140 QLQadGKTCKDFDECSVYG-TCSQLCTNTDGSFICGCVEGYLLQPDNRS 187
Cdd:cd01475 178 KFQ--GKICVVPDLCATLShVCQQVCISTPGSYLCACTEGYALLEDNKT 224

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                          10        20        30
                  ....*....|....*....|....*....|
gi 30851203   119 GCQHHCVPTLDGPTCYCNSSFQLQADGKTC 148
Cdd:pfam14670   7 GCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                        10        20        30
                ....*....|....*....|....*....|....
gi 30851203  27 CSPKQFACRDQiTCISKGWRCDGERDCPDGSDEA 60
Cdd:cd00112   1 CPPNEFRCANG-RCIPSSWVCDGEDDCGDGSDEE 33

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 30851203 140 QLQadGKTCKDFDECSVYG-TCSQLCTNTDGSFICGCVEGYLLQPDNRS 187
Cdd:cd01475 178 KFQ--GKICVVPDLCATLShVCQQVCISTPGSYLCACTEGYALLEDNKT 224

Low-density lipoprotein receptor domain class A;

                          10        20        30
                  ....*....|....*....|....*....|....
gi 30851203    71 RCQPNEHNCLGTElCVPMSRLCNGVQDCMDGSDE 104
Cdd:pfam00057   2 TCSPNEFQCGSGE-CIPRSWVCDGDPDCGDGSDE 34

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                        10        20        30
                ....*....|....*....|....*....|...
gi 30851203  72 CQPNEHNClGTELCVPMSRLCNGVQDCMDGSDE 104
Cdd:cd00112   1 CPPNEFRC-ANGRCIPSSWVCDGEDDCGDGSDE 32

Calcium-binding EGF-like domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 30851203    150 DFDECSVYGTCSQ--LCTNTDGSFICGCVEGY 179
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGY 32

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                        10        20        30
                ....*....|....*....|....*....|....
gi 30851203  27 CSPKQFACRDQiTCISKGWRCDGERDCPDGSDEA 60
Cdd:cd00112   1 CPPNEFRCANG-RCIPSSWVCDGEDDCGDGSDEE 33

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 30851203 140 QLQadGKTCKDFDECSVYG-TCSQLCTNTDGSFICGCVEGYLLQPDNRS 187
Cdd:cd01475 178 KFQ--GKICVVPDLCATLShVCQQVCISTPGSYLCACTEGYALLEDNKT 224

Low-density lipoprotein receptor domain class A;

                          10        20        30
                  ....*....|....*....|....*....|....
gi 30851203    71 RCQPNEHNCLGTElCVPMSRLCNGVQDCMDGSDE 104
Cdd:pfam00057   2 TCSPNEFQCGSGE-CIPRSWVCDGDPDCGDGSDE 34

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                        10        20        30
                ....*....|....*....|....*....|...
gi 30851203  72 CQPNEHNClGTELCVPMSRLCNGVQDCMDGSDE 104
Cdd:cd00112   1 CPPNEFRC-ANGRCIPSSWVCDGEDDCGDGSDE 32

Calcium-binding EGF-like domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 30851203    150 DFDECSVYGTCSQ--LCTNTDGSFICGCVEGY 179
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGY 32