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Conserved domains on  [gi|27503689|gb|AAH42574|]
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Hect domain and RLD 3 [Mus musculus]

Protein Classification

E3 ubiquitin-protein ligase HERC family protein( domain architecture ID 18806229)

E3 ubiquitin-protein ligase HERC (HECT and RCC1 domain) family protein similar to human E3 ISG15--protein ligase HERC5, the major E3 ligase for ISG15 conjugation, that functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HECTc cd00078
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
 702-1048 6.13e-142

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


:

Pssm-ID: 238033 [Multi-domain]  Cd Length: 352  Bit Score: 429.29  E-value: 6.13e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689  702 LVLHVRRNHLVGDALRELSIHSDIDLKKPLKVIFDGEEGVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDS-NLLWFSDT 780
Cdd:cd00078    1 LKITVRRDRILEDALRQLSKVSSSDLKKVLEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPDDsGLLYPNPS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689  781 CFV---EHNWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPSLEDLKELSPTEGRSLQELLDYPGEdiEETFCLNF 857
Cdd:cd00078   81 SFAdedHLKLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLSLEDLEELDPELYKSLKELLDNDGD--EDDLELTF 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689  858 TVCR-ESYGVIEQKKLIPGGDRVAVCKDNRQEFVDAYVNYIFQISVHEWYTAFSSGFLKVCGGKVLELFQPAELRAMMVG 936
Cdd:cd00078  159 TIELdSSFGGAVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICG 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689  937 NSNYDWEELEETAVYRGDYSSTHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQ--IIIQSTATGEEYLPV 1014
Cdd:cd00078  239 SEDIDLEDLKKNTEYKGGYSSDSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGFADLNpkFTIRRVGSPDDRLPT 318

                        330       340       350
                 ....*....|....*....|....*....|....
gi 27503689 1015 AHTCYNLLDLPKYSSKEIMKARLTQALDNYEGFS 1048
Cdd:cd00078  319 AHTCFNLLKLPPYSSKEILREKLLYAINEGAGFG 352
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 3-341 1.74e-79

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 263.38  E-value: 1.74e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689    3 CWGYWSLGQPGISSNLQGIVAEpqvcRFVSDRSIKEVACGGNHSVFLLEDGEVYTCGVNTKGQLG--HEREGNKPEQIGA 80
Cdd:COG5184   21 CWGDNSYGQLGDGTTTDRSTPV----RVPGLSNVVAVAAGGDHTCALKADGTVWCWGNNSYGQLGdgTTTDRTTPVKVPG 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689   81 LADqhIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSvAVPRLIQkLNQQTILQVSCGNWHCLALAADGQFFT 160
Cdd:COG5184   97 LTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNR-LTPVQVD-AGLSGVVAIAAGGYHTCALKSDGTVWC 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689  161 WGKNSHGQLGLGkEFPSQTSPQRVRSLEGIplAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLR 240
Cdd:COG5184  173 WGANSYGQLGDG-TTTDRPTPVQVGGLSGV--VAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVAGLT 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689  241 TqkVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSVNDEVNPRRVLELmgSEVTQIACGRQHTLALVpSSGLIYAFG 320
Cdd:COG5184  250 G--VVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGL--SGVVAVAAGSSHTCALL-TDGTVWCWG 324

                        330       340
                 ....*....|....*....|.
gi 27503689  321 CGAKGQLGTGHTCNVkcPSPV 341
Cdd:COG5184  325 DNAYGQLGDGTTTDR--STPV 343
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
313-377 2.34e-07

Regulator of chromosome condensation (RCC1) repeat;


:

Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 48.28  E-value: 2.34e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27503689    313 SGLIYAFGCGAKGQLGTGHTCNVKCPSPVKGhwaahssqlsaradrFKYRVVKQIFSGGDQTFVL 377
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEG---------------LSGNKVVQVACGGDHTVAL 50
 
Name Accession Description Interval E-value
HECTc cd00078
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
 702-1048 6.13e-142

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


Pssm-ID: 238033 [Multi-domain]  Cd Length: 352  Bit Score: 429.29  E-value: 6.13e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689  702 LVLHVRRNHLVGDALRELSIHSDIDLKKPLKVIFDGEEGVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDS-NLLWFSDT 780
Cdd:cd00078    1 LKITVRRDRILEDALRQLSKVSSSDLKKVLEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPDDsGLLYPNPS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689  781 CFV---EHNWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPSLEDLKELSPTEGRSLQELLDYPGEdiEETFCLNF 857
Cdd:cd00078   81 SFAdedHLKLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLSLEDLEELDPELYKSLKELLDNDGD--EDDLELTF 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689  858 TVCR-ESYGVIEQKKLIPGGDRVAVCKDNRQEFVDAYVNYIFQISVHEWYTAFSSGFLKVCGGKVLELFQPAELRAMMVG 936
Cdd:cd00078  159 TIELdSSFGGAVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICG 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689  937 NSNYDWEELEETAVYRGDYSSTHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQ--IIIQSTATGEEYLPV 1014
Cdd:cd00078  239 SEDIDLEDLKKNTEYKGGYSSDSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGFADLNpkFTIRRVGSPDDRLPT 318

                        330       340       350
                 ....*....|....*....|....*....|....
gi 27503689 1015 AHTCYNLLDLPKYSSKEIMKARLTQALDNYEGFS 1048
Cdd:cd00078  319 AHTCFNLLKLPPYSSKEILREKLLYAINEGAGFG 352
HECTc smart00119
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to ...
 726-1047 3.72e-127

Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to E2 enzymes.


Pssm-ID: 214523  Cd Length: 328  Bit Score: 389.67  E-value: 3.72e-127
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689     726 DLKKP-LKVIFDGEEGVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDTCFVEH----NWFHLIGITCGLAIY 800
Cdd:smart00119    1 DLKKRvLEIEFEGEEGLDGGGVTREFFFLLSKELFNPDYGLFRYSPNDYLLYPNPRSGFANeehlSYFRFIGRVLGKALY 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689     801 NSTVVDLHFPLALYKKLLNVKPSLEDLKELSPTEGRSLQEL-LDYPGEDIEEtfcLNFTVCRES-YGVIEQKKLIPGGDR 878
Cdd:smart00119   81 DNRLLDLFFARPFYKKLLGKPVTLHDLESLDPELYKSLKWLlLNNDTSEELD---LTFSIVLTSeFGQVKVVELKPGGSN 157

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689     879 VAVCKDNRQEFVDAYVNYIFQISVHEWYTAFSSGFLKVCGGKVLELFQPAELRAMMVGNSNYDWEELEETAVYRGDYSST 958
Cdd:smart00119  158 IPVTEENKKEYVHLVIEYRLNKGIEKQLEAFREGFSEVIPENLLKLFDPEELELLICGSPEIDVDDLKSNTEYKGGYSAN 237

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689     959 HPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQ--IIIQSTATGEEYLPVAHTCYNLLDLPKYSSKEIMKAR 1036
Cdd:smart00119  238 SQTIKWFWEVVESFTNEERRKLLQFVTGSSRLPVGGFAALSpkFTIRKAGSDDERLPTAHTCFNRLKLPPYSSKEILREK 317

                           330
                    ....*....|.
gi 27503689    1037 LTQALDNYEGF 1047
Cdd:smart00119  318 LLLAINEGKGF 328
HECT pfam00632
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl ...
 760-1050 2.49e-99

HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.


Pssm-ID: 459880  Cd Length: 304  Bit Score: 315.32  E-value: 2.49e-99
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689    760 NPIYGMFTY-YQDSNLLWFSDTCFVEH-----NWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPSLEDLKELSPT 833
Cdd:pfam00632    9 DPNYGLFEYeTEDDRTYWFNPSSSESPdlellDYFKFLGKLLGKAIYNGILLDLPFPPFFYKKLLGEPLTLEDLESIDPE 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689    834 EGRSLQELLDYPgEDIEETFCLNFTVcrESYGVIEQKKLIPGGDRVAVCKDNRQEFVDAYVNYIFQISVHEWYTAFSSGF 913
Cdd:pfam00632   89 LYKSLKSLLNMD-NDDDEDLGLTFTI--PVFGESKTIELIPNGRNIPVTNENKEEYIRLYVDYRLNKSIEPQLEAFRKGF 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689    914 LKVCGGKVLELFQPAELRAMMVGNSNYDWEELEETAVYRGDYSSTHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIY 993
Cdd:pfam00632  166 YSVIPKEALSLFTPEELELLICGSPEIDVEDLKKNTEYDGGYTKNSPTIQWFWEILEEFSPEQRRLFLKFVTGSSRLPVG 245

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 27503689    994 GMASLQ-IIIQS-TATGEEYLPVAHTCYNLLDLPKYSSKEIMKARLTQALDNYEGFSLA 1050
Cdd:pfam00632  246 GFKSLPkFTIVRkGGDDDDRLPTAHTCFNRLKLPDYSSKEILKEKLLIAIEEGEGFGLS 304
HUL4 COG5021
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
392-1050 9.65e-89

Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227354 [Multi-domain]  Cd Length: 872  Bit Score: 304.38  E-value: 9.65e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689  392 TVNQTHYTNLINDETIAVWRQKLTEHNN------ANTVNGVVQILSSAACWNGSFLKKKIDEHFKTSPKI---PGIDLNS 462
Cdd:COG5021  198 AVSNVEKSEPDNVLFGLPYRSALTMRTNflkldtGNLSGEVQALLARYISIKLVIKKLYLGPGPDASSRIstlIIRLSNT 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689  463 TRILFEKLmHSQHSMILEQILnsfescLIPQLSSSPPDVEAMRIYLILPEFpLLQDSKYyiTLTIPLAMAILRLETNPSK 542
Cdd:COG5021  278 NLNRRLSY-ILSHSSFEDSLL------RLNSLFSTRADSFGRTYYLDHDRI-LTQYSRP--LLEETLGESTSFLVVNNDD 347

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689  543 VLDNWWSQACPKYFMKLVTLYKGAVLYLLRGRKTFLipvLFNNYMTatlkLLEKLYKVN---LKVKHVEYDKFY-IPEIS 618
Cdd:COG5021  348 SSSIKDLPHQVGSNPFLEAHPEFSELLKNQSRGTTR---DFRNKPT----GWSSSIEDLgqfLFSDFLTSSSTYeDLRRE 420

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689  619 SLVdiqEDYLMWFLHQSGMKAR--------PSIMQDAVTLcSYPFIFDAQAKTKMLQTDAELQMQVAVNGANLQNVFMLL 690
Cdd:COG5021  421 QLG---RESDESFYVASNVQQQrasregplLSGWKTRLNN-LYRFYFVEHRKKTLTKNDSRLGSFISLNKLDIRRIKEDK 496

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689  691 TLEPLLARS-------PFLVLHVRRNHLVGDALRELSIHSDIDLKKPLKVIFDGEEGVDAGGVTKEFFLLLLKELLNPIY 763
Cdd:COG5021  497 RRKLFYSLKqkakifdPYLHIKVRRDRVFEDSYREIMDESGDDLKKTLEIEFVGEEGIDAGGLTREWLFLLSKEMFNPDY 576

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689  764 GMFTYYQDSNL-LWFSDTCFV--EH-NWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPSLEDLKELSPTEGRSLQ 839
Cdd:COG5021  577 GLFEYITEDLYtLPINPLSSInpEHlSYFKFLGRVIGKAIYDSRILDVQFSKAFYKKLLGKPVSLVDLESLDPELYRSLV 656

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689  840 ELLDYPGEdiEETFCLNFTVCRESYGVIEQKKLIPGGDRVAVCKDNRQEFVDAYVNYIFQISVHEWYTAFSSGFLKVCGG 919
Cdd:COG5021  657 WLLNNDID--ETILDLTFTVEDDSFGESRTVELIPNGRNISVTNENKKEYVKKVVDYKLNKRVEKQFSAFKSGFSEIIPP 734

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689  920 KVLELFQPAELRAMMVG-NSNYDWEELEETAVYRGdYSSTHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASL 998
Cdd:COG5021  735 DLLQIFDESELELLIGGiPEDIDIDDWKSNTAYHG-YTEDSPIIVWFWEIISEFDFEERAKLLQFVTGTSRIPINGFKDL 813

                        650       660       670       680       690
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 27503689  999 Q-------IIIQSTATGEEYLPVAHTCYNLLDLPKYSSKEIMKARLTQALDNYEGFSLA 1050
Cdd:COG5021  814 QgsdgvrkFTIEKGGTDDDRLPSAHTCFNRLKLPEYSSKEKLRSKLLTAINEGAGFGLL 872
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 3-341 1.74e-79

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 263.38  E-value: 1.74e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689    3 CWGYWSLGQPGISSNLQGIVAEpqvcRFVSDRSIKEVACGGNHSVFLLEDGEVYTCGVNTKGQLG--HEREGNKPEQIGA 80
Cdd:COG5184   21 CWGDNSYGQLGDGTTTDRSTPV----RVPGLSNVVAVAAGGDHTCALKADGTVWCWGNNSYGQLGdgTTTDRTTPVKVPG 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689   81 LADqhIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSvAVPRLIQkLNQQTILQVSCGNWHCLALAADGQFFT 160
Cdd:COG5184   97 LTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNR-LTPVQVD-AGLSGVVAIAAGGYHTCALKSDGTVWC 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689  161 WGKNSHGQLGLGkEFPSQTSPQRVRSLEGIplAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLR 240
Cdd:COG5184  173 WGANSYGQLGDG-TTTDRPTPVQVGGLSGV--VAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVAGLT 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689  241 TqkVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSVNDEVNPRRVLELmgSEVTQIACGRQHTLALVpSSGLIYAFG 320
Cdd:COG5184  250 G--VVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGL--SGVVAVAAGSSHTCALL-TDGTVWCWG 324

                        330       340
                 ....*....|....*....|.
gi 27503689  321 CGAKGQLGTGHTCNVkcPSPV 341
Cdd:COG5184  325 DNAYGQLGDGTTTDR--STPV 343
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
208-257 5.71e-15

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 69.85  E-value: 5.71e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 27503689    208 SGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVL 257
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
313-377 2.34e-07

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 48.28  E-value: 2.34e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27503689    313 SGLIYAFGCGAKGQLGTGHTCNVKCPSPVKGhwaahssqlsaradrFKYRVVKQIFSGGDQTFVL 377
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEG---------------LSGNKVVQVACGGDHTVAL 50
 
Name Accession Description Interval E-value
HECTc cd00078
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
 702-1048 6.13e-142

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


Pssm-ID: 238033 [Multi-domain]  Cd Length: 352  Bit Score: 429.29  E-value: 6.13e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689  702 LVLHVRRNHLVGDALRELSIHSDIDLKKPLKVIFDGEEGVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDS-NLLWFSDT 780
Cdd:cd00078    1 LKITVRRDRILEDALRQLSKVSSSDLKKVLEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPDDsGLLYPNPS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689  781 CFV---EHNWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPSLEDLKELSPTEGRSLQELLDYPGEdiEETFCLNF 857
Cdd:cd00078   81 SFAdedHLKLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLSLEDLEELDPELYKSLKELLDNDGD--EDDLELTF 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689  858 TVCR-ESYGVIEQKKLIPGGDRVAVCKDNRQEFVDAYVNYIFQISVHEWYTAFSSGFLKVCGGKVLELFQPAELRAMMVG 936
Cdd:cd00078  159 TIELdSSFGGAVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICG 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689  937 NSNYDWEELEETAVYRGDYSSTHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQ--IIIQSTATGEEYLPV 1014
Cdd:cd00078  239 SEDIDLEDLKKNTEYKGGYSSDSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGFADLNpkFTIRRVGSPDDRLPT 318

                        330       340       350
                 ....*....|....*....|....*....|....
gi 27503689 1015 AHTCYNLLDLPKYSSKEIMKARLTQALDNYEGFS 1048
Cdd:cd00078  319 AHTCFNLLKLPPYSSKEILREKLLYAINEGAGFG 352
HECTc smart00119
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to ...
 726-1047 3.72e-127

Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to E2 enzymes.


Pssm-ID: 214523  Cd Length: 328  Bit Score: 389.67  E-value: 3.72e-127
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689     726 DLKKP-LKVIFDGEEGVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDTCFVEH----NWFHLIGITCGLAIY 800
Cdd:smart00119    1 DLKKRvLEIEFEGEEGLDGGGVTREFFFLLSKELFNPDYGLFRYSPNDYLLYPNPRSGFANeehlSYFRFIGRVLGKALY 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689     801 NSTVVDLHFPLALYKKLLNVKPSLEDLKELSPTEGRSLQEL-LDYPGEDIEEtfcLNFTVCRES-YGVIEQKKLIPGGDR 878
Cdd:smart00119   81 DNRLLDLFFARPFYKKLLGKPVTLHDLESLDPELYKSLKWLlLNNDTSEELD---LTFSIVLTSeFGQVKVVELKPGGSN 157

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689     879 VAVCKDNRQEFVDAYVNYIFQISVHEWYTAFSSGFLKVCGGKVLELFQPAELRAMMVGNSNYDWEELEETAVYRGDYSST 958
Cdd:smart00119  158 IPVTEENKKEYVHLVIEYRLNKGIEKQLEAFREGFSEVIPENLLKLFDPEELELLICGSPEIDVDDLKSNTEYKGGYSAN 237

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689     959 HPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQ--IIIQSTATGEEYLPVAHTCYNLLDLPKYSSKEIMKAR 1036
Cdd:smart00119  238 SQTIKWFWEVVESFTNEERRKLLQFVTGSSRLPVGGFAALSpkFTIRKAGSDDERLPTAHTCFNRLKLPPYSSKEILREK 317

                           330
                    ....*....|.
gi 27503689    1037 LTQALDNYEGF 1047
Cdd:smart00119  318 LLLAINEGKGF 328
HECT pfam00632
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl ...
 760-1050 2.49e-99

HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.


Pssm-ID: 459880  Cd Length: 304  Bit Score: 315.32  E-value: 2.49e-99
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689    760 NPIYGMFTY-YQDSNLLWFSDTCFVEH-----NWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPSLEDLKELSPT 833
Cdd:pfam00632    9 DPNYGLFEYeTEDDRTYWFNPSSSESPdlellDYFKFLGKLLGKAIYNGILLDLPFPPFFYKKLLGEPLTLEDLESIDPE 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689    834 EGRSLQELLDYPgEDIEETFCLNFTVcrESYGVIEQKKLIPGGDRVAVCKDNRQEFVDAYVNYIFQISVHEWYTAFSSGF 913
Cdd:pfam00632   89 LYKSLKSLLNMD-NDDDEDLGLTFTI--PVFGESKTIELIPNGRNIPVTNENKEEYIRLYVDYRLNKSIEPQLEAFRKGF 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689    914 LKVCGGKVLELFQPAELRAMMVGNSNYDWEELEETAVYRGDYSSTHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIY 993
Cdd:pfam00632  166 YSVIPKEALSLFTPEELELLICGSPEIDVEDLKKNTEYDGGYTKNSPTIQWFWEILEEFSPEQRRLFLKFVTGSSRLPVG 245

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 27503689    994 GMASLQ-IIIQS-TATGEEYLPVAHTCYNLLDLPKYSSKEIMKARLTQALDNYEGFSLA 1050
Cdd:pfam00632  246 GFKSLPkFTIVRkGGDDDDRLPTAHTCFNRLKLPDYSSKEILKEKLLIAIEEGEGFGLS 304
HUL4 COG5021
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
392-1050 9.65e-89

Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227354 [Multi-domain]  Cd Length: 872  Bit Score: 304.38  E-value: 9.65e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689  392 TVNQTHYTNLINDETIAVWRQKLTEHNN------ANTVNGVVQILSSAACWNGSFLKKKIDEHFKTSPKI---PGIDLNS 462
Cdd:COG5021  198 AVSNVEKSEPDNVLFGLPYRSALTMRTNflkldtGNLSGEVQALLARYISIKLVIKKLYLGPGPDASSRIstlIIRLSNT 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689  463 TRILFEKLmHSQHSMILEQILnsfescLIPQLSSSPPDVEAMRIYLILPEFpLLQDSKYyiTLTIPLAMAILRLETNPSK 542
Cdd:COG5021  278 NLNRRLSY-ILSHSSFEDSLL------RLNSLFSTRADSFGRTYYLDHDRI-LTQYSRP--LLEETLGESTSFLVVNNDD 347

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689  543 VLDNWWSQACPKYFMKLVTLYKGAVLYLLRGRKTFLipvLFNNYMTatlkLLEKLYKVN---LKVKHVEYDKFY-IPEIS 618
Cdd:COG5021  348 SSSIKDLPHQVGSNPFLEAHPEFSELLKNQSRGTTR---DFRNKPT----GWSSSIEDLgqfLFSDFLTSSSTYeDLRRE 420

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689  619 SLVdiqEDYLMWFLHQSGMKAR--------PSIMQDAVTLcSYPFIFDAQAKTKMLQTDAELQMQVAVNGANLQNVFMLL 690
Cdd:COG5021  421 QLG---RESDESFYVASNVQQQrasregplLSGWKTRLNN-LYRFYFVEHRKKTLTKNDSRLGSFISLNKLDIRRIKEDK 496

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689  691 TLEPLLARS-------PFLVLHVRRNHLVGDALRELSIHSDIDLKKPLKVIFDGEEGVDAGGVTKEFFLLLLKELLNPIY 763
Cdd:COG5021  497 RRKLFYSLKqkakifdPYLHIKVRRDRVFEDSYREIMDESGDDLKKTLEIEFVGEEGIDAGGLTREWLFLLSKEMFNPDY 576

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689  764 GMFTYYQDSNL-LWFSDTCFV--EH-NWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPSLEDLKELSPTEGRSLQ 839
Cdd:COG5021  577 GLFEYITEDLYtLPINPLSSInpEHlSYFKFLGRVIGKAIYDSRILDVQFSKAFYKKLLGKPVSLVDLESLDPELYRSLV 656

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689  840 ELLDYPGEdiEETFCLNFTVCRESYGVIEQKKLIPGGDRVAVCKDNRQEFVDAYVNYIFQISVHEWYTAFSSGFLKVCGG 919
Cdd:COG5021  657 WLLNNDID--ETILDLTFTVEDDSFGESRTVELIPNGRNISVTNENKKEYVKKVVDYKLNKRVEKQFSAFKSGFSEIIPP 734

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689  920 KVLELFQPAELRAMMVG-NSNYDWEELEETAVYRGdYSSTHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASL 998
Cdd:COG5021  735 DLLQIFDESELELLIGGiPEDIDIDDWKSNTAYHG-YTEDSPIIVWFWEIISEFDFEERAKLLQFVTGTSRIPINGFKDL 813

                        650       660       670       680       690
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 27503689  999 Q-------IIIQSTATGEEYLPVAHTCYNLLDLPKYSSKEIMKARLTQALDNYEGFSLA 1050
Cdd:COG5021  814 QgsdgvrkFTIEKGGTDDDRLPSAHTCFNRLKLPEYSSKEKLRSKLLTAINEGAGFGLL 872
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 3-341 1.74e-79

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 263.38  E-value: 1.74e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689    3 CWGYWSLGQPGISSNLQGIVAEpqvcRFVSDRSIKEVACGGNHSVFLLEDGEVYTCGVNTKGQLG--HEREGNKPEQIGA 80
Cdd:COG5184   21 CWGDNSYGQLGDGTTTDRSTPV----RVPGLSNVVAVAAGGDHTCALKADGTVWCWGNNSYGQLGdgTTTDRTTPVKVPG 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689   81 LADqhIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSvAVPRLIQkLNQQTILQVSCGNWHCLALAADGQFFT 160
Cdd:COG5184   97 LTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNR-LTPVQVD-AGLSGVVAIAAGGYHTCALKSDGTVWC 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689  161 WGKNSHGQLGLGkEFPSQTSPQRVRSLEGIplAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLR 240
Cdd:COG5184  173 WGANSYGQLGDG-TTTDRPTPVQVGGLSGV--VAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVAGLT 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689  241 TqkVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSVNDEVNPRRVLELmgSEVTQIACGRQHTLALVpSSGLIYAFG 320
Cdd:COG5184  250 G--VVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGL--SGVVAVAAGSSHTCALL-TDGTVWCWG 324

                        330       340
                 ....*....|....*....|.
gi 27503689  321 CGAKGQLGTGHTCNVkcPSPV 341
Cdd:COG5184  325 DNAYGQLGDGTTTDR--STPV 343
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 38-343 6.56e-73

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 245.27  E-value: 6.56e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689   38 EVACGGNHSVFLLEDGEVYTCGVNTKGQLGHEREGN--KPEQIGALADqhIIHVACGESHSLALSDRGQLFSWGAGSDGQ 115
Cdd:COG5184    2 QVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDrsTPVRVPGLSN--VVAVAAGGDHTCALKADGTVWCWGNNSYGQ 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689  116 LGLMTTEDSvAVPRLIQKLNqqTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGkEFPSQTSPQRVR-SLEGIplAQ 194
Cdd:COG5184   80 LGDGTTTDR-TTPVKVPGLT--GVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDG-TTTNRLTPVQVDaGLSGV--VA 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689  195 VAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTqkVVYISCGEEHTAVLTKSGGVFTFGAGSCGQL 274
Cdd:COG5184  154 IAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGLSG--VVAVAAGGDHSCALKSDGTVWCWGSNSSGQL 231

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27503689  275 GHDSVNDEVNPRRVLELMGseVTQIACGRQHTLALVpSSGLIYAFGCGAKGQLGTGHTCNVKCPSPVKG 343
Cdd:COG5184  232 GDGTTTDRATPVQVAGLTG--VVAIAAGGSHTCALK-SDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPG 297
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 87-343 9.99e-64

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 219.85  E-value: 9.99e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689   87 IHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSvAVPRLIQKLnqQTILQVSCGNWHCLALAADGQFFTWGKNSH 166
Cdd:COG5184    1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDR-STPVRVPGL--SNVVAVAAGGDHTCALKADGTVWCWGNNSY 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689  167 GQLGLGKEFPSQTsPQRVRSLEGIplAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVkLLRTQKVVY 246
Cdd:COG5184   78 GQLGDGTTTDRTT-PVKVPGLTGV--VAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQV-DAGLSGVVA 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689  247 ISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSVNDEVNPRRVLELmgSEVTQIACGRQHTLALVpSSGLIYAFGCGAKGQ 326
Cdd:COG5184  154 IAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGL--SGVVAVAAGGDHSCALK-SDGTVWCWGSNSSGQ 230

                        250
                 ....*....|....*..
gi 27503689  327 LGTGHTCNVKCPSPVKG 343
Cdd:COG5184  231 LGDGTTTDRATPVQVAG 247
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 1-233 1.29e-36

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 141.65  E-value: 1.29e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689    1 MLCWGYWSLGQPGISSNlqgivaepqvcrfvSDRSIkevacggnhsvflledgevytcgvntkgqlgheregnkPEQIGA 80
Cdd:COG5184  170 VWCWGANSYGQLGDGTT--------------TDRPT--------------------------------------PVQVGG 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689   81 LADqhIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSvAVPRLIQKLNqqTILQVSCGNWHCLALAADGQFFT 160
Cdd:COG5184  198 LSG--VVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDR-ATPVQVAGLT--GVVAIAAGGSHTCALKSDGTVWC 272

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 27503689  161 WGKNSHGQLGLGKEfPSQTSPQRVRSLEGIplAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESP 233
Cdd:COG5184  273 WGDNSYGQLGDGTT-TDRSTPVKVPGLSGV--VAVAAGSSHTCALLTDGTVWCWGDNAYGQLGDGTTTDRSTP 342
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 193-377 9.26e-34

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 133.18  E-value: 9.26e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689  193 AQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTqkVVYISCGEEHTAVLTKSGGVFTFGAGSCG 272
Cdd:COG5184    1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPGLSN--VVAVAAGGDHTCALKADGTVWCWGNNSYG 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27503689  273 QLGHDSVNDEVNPRRVLELmgSEVTQIACGRQHTLALVpSSGLIYAFGCGAKGQLGTGHTCNVKCPSPVkghwaahSSQL 352
Cdd:COG5184   79 QLGDGTTTDRTTPVKVPGL--TGVVAVAAGYYHSCALK-SDGTVWCWGDNSSGQLGDGTTTNRLTPVQV-------DAGL 148

                        170       180
                 ....*....|....*....|....*
gi 27503689  353 SAradrfkyrvVKQIFSGGDQTFVL 377
Cdd:COG5184  149 SG---------VVAIAAGGYHTCAL 164
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
208-257 5.71e-15

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 69.85  E-value: 5.71e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 27503689    208 SGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVL 257
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
103-152 2.28e-14

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 67.93  E-value: 2.28e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 27503689    103 GQLFSWGAGSDGQLGLMTTEdSVAVPRLIQKLNQQTILQVSCGNWHCLAL 152
Cdd:pfam00415    2 GRVYTWGRNDYGQLGLGTTE-NVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
155-205 1.07e-13

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 66.39  E-value: 1.07e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 27503689    155 DGQFFTWGKNSHGQLGLGKEFpSQTSPQRVRSLEGIPLAQVAAGGAHSFAL 205
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTE-NVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
260-309 2.81e-13

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 64.85  E-value: 2.81e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 27503689    260 SGGVFTFGAGSCGQLGHDSVNDEVNPRRVLELMGSEVTQIACGRQHTLAL 309
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
52-99 3.80e-13

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 64.46  E-value: 3.80e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 27503689     52 DGEVYTCGVNTKGQLGHEREGNK--PEQIGALADQHIIHVACGESHSLAL 99
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTENVlvPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
36-65 8.18e-09

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 51.66  E-value: 8.18e-09
                           10        20        30
                   ....*....|....*....|....*....|
gi 27503689     36 IKEVACGGNHSVFLLEDGEVYTCGVNTKGQ 65
Cdd:pfam13540    1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
139-168 1.03e-07

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 48.57  E-value: 1.03e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 27503689    139 ILQVSCGNWHCLALAADGQFFTWGKNSHGQ 168
Cdd:pfam13540    1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
313-377 2.34e-07

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 48.28  E-value: 2.34e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27503689    313 SGLIYAFGCGAKGQLGTGHTCNVKCPSPVKGhwaahssqlsaradrFKYRVVKQIFSGGDQTFVL 377
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEG---------------LSGNKVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
86-115 3.00e-07

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 47.42  E-value: 3.00e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 27503689     86 IIHVACGESHSLALSDRGQLFSWGAGSDGQ 115
Cdd:pfam13540    1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
193-221 2.93e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 44.72  E-value: 2.93e-06
                           10        20
                   ....*....|....*....|....*....
gi 27503689    193 AQVAAGGAHSFALSLSGAVFGWGMNNAGQ 221
Cdd:pfam13540    2 VSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
244-273 6.95e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 43.57  E-value: 6.95e-06
                           10        20        30
                   ....*....|....*....|....*....|
gi 27503689    244 VVYISCGEEHTAVLTKSGGVFTFGAGSCGQ 273
Cdd:pfam13540    1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
296-326 5.56e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 40.87  E-value: 5.56e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 27503689    296 VTQIACGRQHTLALVpSSGLIYAFGCGAKGQ 326
Cdd:pfam13540    1 VVSVAAGDNHTLALT-SDGRVYCWGDNSYGQ 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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