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Conserved domains on  [gi|23138792|gb|AAH37878|]
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Solute carrier family 35, member F3 [Homo sapiens]

Protein Classification

solute carrier family 35 protein( domain architecture ID 20005166)

solute carrier family 35 protein such as solute carrier family 35 member F3 (SLC35F3), which may be a thiamine transporter; belongs to the DMT (drug/metabolite transporter) superfamily

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhaT super family cl34009
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
 162-345 1.15e-07

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


The actual alignment was detected with superfamily member COG0697:

Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 52.92  E-value: 1.15e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23138792 162 TLTNYLYLHAIKKINTTDVSVLFCCNKAFVFLLSWIVLRDRFMGVRIVAAILAIAGIVMMTYADGFHSHCV-IGIALVVA 240
Cdd:COG0697  77 ALAFLLFFLALQYTPAALAALLLALAPLFVALLAALLLGERLSRRRWLGLLLGFAGVLLIVGPGGGGGGGSlLGDLLALL 156

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23138792 241 SASMSALYKVLFKLLLGSAKfgeaalflSILGVFNILFITCIPIILYFTKVEYWSSFDDIPWGNLcGFSVLLLTF--NIV 318
Cdd:COG0697 157 AALSWALYTVLTRRLSRRLD--------PLTLTFWQMLVGALLLLPLALLTGLPLPLSAAAWLAL-LYLGLFGTAlaYLL 227

                       170       180
                ....*....|....*....|....*..
gi 23138792 319 LNFGIAVTYPTLMSLGIVLSIPVNAVI 345
Cdd:COG0697 228 WFRALRRLGASRAAPLTYLEPVFAVLL 254
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
 68-223 2.18e-04

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


:

Pssm-ID: 307170  Cd Length: 136  Bit Score: 41.03  E-value: 2.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23138792    68 WGVAVVLCVCSSWAGSTQLAKLTFRKFDAPFTLTWFATNWNFLFFPLYYvghvckstekqsvkqryreccrFFGDNGLTL 147
Cdd:pfam00892   2 KGILLALLAALIWAIYFVFSKILLRRISPLTLTFWRFLIAGILLLPFAL----------------------FTGGKLVIP 59

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 23138792   148 KVFFTKAAPFGVLWT-LTNYLYLHAIKKINTTDVSVLFCCNKAFVFLLSWIVLRDRFMGVRIVAAILAIAGIVMMTY 223
Cdd:pfam00892  60 LKSWLALLYLGVLGTfLGFLLYFYGLKYVSASNASVITSLSPVFTLILSVLLLGEKLTLKQLLGIVLILLGVLLILL 136
LGIC_TM super family cl38911
transmembrane domain of Cys-loop neurotransmitter-gated ion channels; This superfamily ...
 11-80 1.56e-03

transmembrane domain of Cys-loop neurotransmitter-gated ion channels; This superfamily contains the transmembrane domain of Cys-loop neurotransmitter-gated ion channels, which include nicotinic acetylcholine receptor (nAChR), serotonin 5-hydroxytryptamine receptor (5-HT3), type-A gamma-aminobutyric acid receptor (GABAAR), and glycine receptor (GlyR). These ligand-gated ion channels (LGICs) are found across metazoans and have close homologs in bacteria. They are vital for communication throughout the nervous system where the sign of synaptic connections (excitatory or inhibitory) is determined by the charge of the ions that flow through these channels. In general, channels that conduct positive ions are excitatory, whereas channels that conduct negative ions are inhibitory. The transmembrane region consists of four transmembrane-spanning alpha-helical segments (M1-M4) that are linked by loops. The intracellular loop that links M1 and M2 determines the ion selectivity of the channel. GABAAR and GlyR are anionic channels, both mediating fast inhibitory synaptic transmission. Cl- ions are selectively conducted through the GABAAR receptor pore, resulting in hyperpolarization of the neuron. nAChR is a non-selective cation channel that is permeable to Na+ and K+, and some subunit combinations are also permeable to Ca2+. Na+ enters and K+ exits to allow net flow of positively charged ions inward. 5-HT3, a cation-selective channel, binds serotonin and is permeable to Na+, K+, and Ca2+. It mediates neuronal depolarization and excitation within the central and peripheral nervous systems. These ligand-gated chloride channels are critical not only for maintaining appropriate neuronal activity, but have long been important therapeutic targets: benzodiazepines, barbiturates, some intravenous and volatile anaesthetics, alcohol, strychnine, picrotoxin, and ivermectin all derive their biological activity from acting on the inhibitory half of the Cys-loop receptor family.


The actual alignment was detected with superfamily member cd19065:

Pssm-ID: 476813  Cd Length: 176  Bit Score: 39.19  E-value: 1.56e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23138792  11 LSACNSPVLTLtkvEGEERPRDSPGPAEAQAPagveAGGRASRRCWTcsrAQLKKIFWGVAVVLCVCSSW 80
Cdd:cd19065  93 LGAKSSPSPAP---RGEQREHGNPGPHPEEAP----GRGKGSQRSWA---EAADRIFFLVYVVGVLCSQF 152
 
Name Accession Description Interval E-value
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
 162-345 1.15e-07

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 52.92  E-value: 1.15e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23138792 162 TLTNYLYLHAIKKINTTDVSVLFCCNKAFVFLLSWIVLRDRFMGVRIVAAILAIAGIVMMTYADGFHSHCV-IGIALVVA 240
Cdd:COG0697  77 ALAFLLFFLALQYTPAALAALLLALAPLFVALLAALLLGERLSRRRWLGLLLGFAGVLLIVGPGGGGGGGSlLGDLLALL 156

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23138792 241 SASMSALYKVLFKLLLGSAKfgeaalflSILGVFNILFITCIPIILYFTKVEYWSSFDDIPWGNLcGFSVLLLTF--NIV 318
Cdd:COG0697 157 AALSWALYTVLTRRLSRRLD--------PLTLTFWQMLVGALLLLPLALLTGLPLPLSAAAWLAL-LYLGLFGTAlaYLL 227

                       170       180
                ....*....|....*....|....*..
gi 23138792 319 LNFGIAVTYPTLMSLGIVLSIPVNAVI 345
Cdd:COG0697 228 WFRALRRLGASRAAPLTYLEPVFAVLL 254
SLC35F pfam06027
Solute carrier family 35; This is a family of putative solute carrier proteins from eukaryotes.
 165-338 1.12e-05

Solute carrier family 35; This is a family of putative solute carrier proteins from eukaryotes.


Pssm-ID: 283644 [Multi-domain]  Cd Length: 299  Bit Score: 47.06  E-value: 1.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23138792   165 NYLYLHAIKKINTTDVSVLFCCNKAFVFLLSWIVLRDRFMGVRIVAAILAIAGIVMMTYAD-------GFHSHCVIGIAL 237
Cdd:pfam06027  87 NYLVVKAYQYTTMTSVQLLDCWAIPVVLVLSWFFLKTRYRLMHIIGVVVCILGVVMMVGSDvlagrraYSGSNPLKGDFL 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23138792   238 VVASASMSALYKVLFKLLLGSAKFGEAALFLSILGVfnilFITCIPIILYFTKVEYWSSFDDIPWGNLCGFSVLLLTFNI 317
Cdd:pfam06027 167 VLAGATLYAVSNVTEEYIVKKLSRVEFLGMLGLFGA----IISGIQLAIFERKELYAIHWDWEIGLLFVGFALCMFLLYS 242

                         170       180
                  ....*....|....*....|.
gi 23138792   318 VLNFGIAVTYPTLMSLGIVLS 338
Cdd:pfam06027 243 LMPILIKMTSATSVNLSLLTS 263
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
 68-223 2.18e-04

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 41.03  E-value: 2.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23138792    68 WGVAVVLCVCSSWAGSTQLAKLTFRKFDAPFTLTWFATNWNFLFFPLYYvghvckstekqsvkqryreccrFFGDNGLTL 147
Cdd:pfam00892   2 KGILLALLAALIWAIYFVFSKILLRRISPLTLTFWRFLIAGILLLPFAL----------------------FTGGKLVIP 59

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 23138792   148 KVFFTKAAPFGVLWT-LTNYLYLHAIKKINTTDVSVLFCCNKAFVFLLSWIVLRDRFMGVRIVAAILAIAGIVMMTY 223
Cdd:pfam00892  60 LKSWLALLYLGVLGTfLGFLLYFYGLKYVSASNASVITSLSPVFTLILSVLLLGEKLTLKQLLGIVLILLGVLLILL 136
LGIC_TM_ZAC cd19065
transmembrane domain of zinc-activated ligand-gated ion channel; This family contains ...
 11-80 1.56e-03

transmembrane domain of zinc-activated ligand-gated ion channel; This family contains transmembrane (TM) domain of zinc-activated ligand-gated ion channel (ZAC). The transmembrane region consists of four transmembrane-spanning alpha-helical segments (M1-M4) that are linked by loops. The intracellular loop that links M1 and M2 determines the ion selectivity of the channel. ZAC displays low sequence similarity to other members in the superfamily, with closest matches to the human serotonin 5-HT3 receptor (5-HT3R) subunits 5-HT3A and 5-HT3B, and nAChR alpha7 subunits that exhibit approximately 15% amino acid sequence identity to ZAC. Expression of ZAC has been detected in human fetal whole brain, spinal cord, pancreas, placenta, prostate, thyroid, trachea, and stomach, as well as in adult hippocampus, striatum, amygdala, and thalamus. ZAC forms an ion channel gated by Zn2+, Cu2+, and H+, and is non-selectively permeable to monovalent cations. However, the role of ZAC in Zn2+, Cu2+, and H+ signaling is as yet unknown.


Pssm-ID: 349867  Cd Length: 176  Bit Score: 39.19  E-value: 1.56e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23138792  11 LSACNSPVLTLtkvEGEERPRDSPGPAEAQAPagveAGGRASRRCWTcsrAQLKKIFWGVAVVLCVCSSW 80
Cdd:cd19065  93 LGAKSSPSPAP---RGEQREHGNPGPHPEEAP----GRGKGSQRSWA---EAADRIFFLVYVVGVLCSQF 152
 
Name Accession Description Interval E-value
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
 162-345 1.15e-07

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 52.92  E-value: 1.15e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23138792 162 TLTNYLYLHAIKKINTTDVSVLFCCNKAFVFLLSWIVLRDRFMGVRIVAAILAIAGIVMMTYADGFHSHCV-IGIALVVA 240
Cdd:COG0697  77 ALAFLLFFLALQYTPAALAALLLALAPLFVALLAALLLGERLSRRRWLGLLLGFAGVLLIVGPGGGGGGGSlLGDLLALL 156

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23138792 241 SASMSALYKVLFKLLLGSAKfgeaalflSILGVFNILFITCIPIILYFTKVEYWSSFDDIPWGNLcGFSVLLLTF--NIV 318
Cdd:COG0697 157 AALSWALYTVLTRRLSRRLD--------PLTLTFWQMLVGALLLLPLALLTGLPLPLSAAAWLAL-LYLGLFGTAlaYLL 227

                       170       180
                ....*....|....*....|....*..
gi 23138792 319 LNFGIAVTYPTLMSLGIVLSIPVNAVI 345
Cdd:COG0697 228 WFRALRRLGASRAAPLTYLEPVFAVLL 254
SLC35F pfam06027
Solute carrier family 35; This is a family of putative solute carrier proteins from eukaryotes.
 165-338 1.12e-05

Solute carrier family 35; This is a family of putative solute carrier proteins from eukaryotes.


Pssm-ID: 283644 [Multi-domain]  Cd Length: 299  Bit Score: 47.06  E-value: 1.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23138792   165 NYLYLHAIKKINTTDVSVLFCCNKAFVFLLSWIVLRDRFMGVRIVAAILAIAGIVMMTYAD-------GFHSHCVIGIAL 237
Cdd:pfam06027  87 NYLVVKAYQYTTMTSVQLLDCWAIPVVLVLSWFFLKTRYRLMHIIGVVVCILGVVMMVGSDvlagrraYSGSNPLKGDFL 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23138792   238 VVASASMSALYKVLFKLLLGSAKFGEAALFLSILGVfnilFITCIPIILYFTKVEYWSSFDDIPWGNLCGFSVLLLTFNI 317
Cdd:pfam06027 167 VLAGATLYAVSNVTEEYIVKKLSRVEFLGMLGLFGA----IISGIQLAIFERKELYAIHWDWEIGLLFVGFALCMFLLYS 242

                         170       180
                  ....*....|....*....|.
gi 23138792   318 VLNFGIAVTYPTLMSLGIVLS 338
Cdd:pfam06027 243 LMPILIKMTSATSVNLSLLTS 263
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
 68-223 2.18e-04

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 41.03  E-value: 2.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23138792    68 WGVAVVLCVCSSWAGSTQLAKLTFRKFDAPFTLTWFATNWNFLFFPLYYvghvckstekqsvkqryreccrFFGDNGLTL 147
Cdd:pfam00892   2 KGILLALLAALIWAIYFVFSKILLRRISPLTLTFWRFLIAGILLLPFAL----------------------FTGGKLVIP 59

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 23138792   148 KVFFTKAAPFGVLWT-LTNYLYLHAIKKINTTDVSVLFCCNKAFVFLLSWIVLRDRFMGVRIVAAILAIAGIVMMTY 223
Cdd:pfam00892  60 LKSWLALLYLGVLGTfLGFLLYFYGLKYVSASNASVITSLSPVFTLILSVLLLGEKLTLKQLLGIVLILLGVLLILL 136
LGIC_TM_ZAC cd19065
transmembrane domain of zinc-activated ligand-gated ion channel; This family contains ...
 11-80 1.56e-03

transmembrane domain of zinc-activated ligand-gated ion channel; This family contains transmembrane (TM) domain of zinc-activated ligand-gated ion channel (ZAC). The transmembrane region consists of four transmembrane-spanning alpha-helical segments (M1-M4) that are linked by loops. The intracellular loop that links M1 and M2 determines the ion selectivity of the channel. ZAC displays low sequence similarity to other members in the superfamily, with closest matches to the human serotonin 5-HT3 receptor (5-HT3R) subunits 5-HT3A and 5-HT3B, and nAChR alpha7 subunits that exhibit approximately 15% amino acid sequence identity to ZAC. Expression of ZAC has been detected in human fetal whole brain, spinal cord, pancreas, placenta, prostate, thyroid, trachea, and stomach, as well as in adult hippocampus, striatum, amygdala, and thalamus. ZAC forms an ion channel gated by Zn2+, Cu2+, and H+, and is non-selectively permeable to monovalent cations. However, the role of ZAC in Zn2+, Cu2+, and H+ signaling is as yet unknown.


Pssm-ID: 349867  Cd Length: 176  Bit Score: 39.19  E-value: 1.56e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23138792  11 LSACNSPVLTLtkvEGEERPRDSPGPAEAQAPagveAGGRASRRCWTcsrAQLKKIFWGVAVVLCVCSSW 80
Cdd:cd19065  93 LGAKSSPSPAP---RGEQREHGNPGPHPEEAP----GRGKGSQRSWA---EAADRIFFLVYVVGVLCSQF 152
RibN COG2510
Riboflavin transporter RibN, EamA domain [Coenzyme transport and metabolism];
158-224 2.69e-03

Riboflavin transporter RibN, EamA domain [Coenzyme transport and metabolism];


Pssm-ID: 442000  Cd Length: 138  Bit Score: 37.86  E-value: 2.69e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 23138792 158 GVLWTLTNYLYLHAIKKINTTDVSVLFCCNKAFVFLLSWIVLRDRFMGVRIVAAILAIAGIVMMTYA 224
Cdd:COG2510  72 GLATGLSWLFYFRALKLGPASIVAPIDKLSPVFTVLLSVLFLGERLTLKQIIGILLIVAGVILLSLK 138
RhtA COG5006
Threonine/homoserine efflux transporter RhtA [Amino acid transport and metabolism];
154-251 5.89e-03

Threonine/homoserine efflux transporter RhtA [Amino acid transport and metabolism];


Pssm-ID: 444030 [Multi-domain]  Cd Length: 290  Bit Score: 38.26  E-value: 5.89e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23138792 154 AAPFGVLWTLTNYLYLHAIKKINTTDVSVLFCCNKAFVFLLSWIVLRDrfmgvrIVAAILAIAGIVMMTYA-DGFHSHCV 232
Cdd:COG5006  71 LLLYGVALAGMNLLFYLAIARIPLGIAVALEFLGPLAVALLGSRRRRD------LLWVALALAGVVLLLPVgLSGGSLDP 144

                        90
                ....*....|....*....
gi 23138792 233 IGIALVVASASMSALYKVL 251
Cdd:COG5006 145 VGVLFALGAAACWALYILL 163
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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