NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|71051465|gb|AAH27608|]
View 

ZNF486 protein, partial [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
53-111 1.30e-30

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 113.07  E-value: 1.30e-30
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 71051465     53 LQFRDVAVEFSLEEWHCLDTAQQNLYRDVMLENYRHLVFLGIIVSKPDLITCLEQGIKP 111
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
228-503 3.54e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 3.54e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71051465 228 DKAFNQSSTHTtHKKIDTGEKPYKCEECGKAFNRSSHLTTHKITHTREKPYKC--EECGKVFKYFSSFTTHKKIHSGE-- 303
Cdd:COG5048  13 NSVLSSTPKST-LKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNps 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71051465 304 ---------------------------KPYICEECGKAFMYPYTLT--THKIIHTGEQPYK-----CKECDKAFNHPATL 349
Cdd:COG5048  92 dlnskslplsnskasssslsssssnsnDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLPgnnssSVNTPQSNSLHPPL 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71051465 350 S---------------SHKKIHTGEKPYTCDKCGKAFISSSILSKHEKIHTGEKPYKCEECGKAF----TRSSHLTMHKI 410
Cdd:COG5048 172 PanslskdpssnlsllISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpkslLSQSPSSLSSS 251

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71051465 411 IHTGEKPYKCEECG--KAFTWSAGLHKHRRTHTG-EKPYKCEECGKAYTTSSNLTEHK--TTHTGE--KPYKCKE--CGK 481
Cdd:COG5048 252 DSSSSASESPRSSLptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGK 331

                       330       340
                ....*....|....*....|..
gi 71051465 482 AFNWSSDLNKHKRIHIGQKKKK 503
Cdd:COG5048 332 LFSRNDALKRHILLHTSISPAK 353
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
53-111 1.30e-30

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 113.07  E-value: 1.30e-30
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 71051465     53 LQFRDVAVEFSLEEWHCLDTAQQNLYRDVMLENYRHLVFLGIIVSKPDLITCLEQGIKP 111
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 55-93 7.67e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.21  E-value: 7.67e-21
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 71051465    55 FRDVAVEFSLEEWHCLDTAQQNLYRDVMLENYRHLVFLG 93
Cdd:pfam01352   4 FEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 55-92 2.36e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 78.36  E-value: 2.36e-18
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 71051465  55 FRDVAVEFSLEEWHCLDTAQQNLYRDVMLENYRHLVFL 92
Cdd:cd07765   3 FEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
228-503 3.54e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 3.54e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71051465 228 DKAFNQSSTHTtHKKIDTGEKPYKCEECGKAFNRSSHLTTHKITHTREKPYKC--EECGKVFKYFSSFTTHKKIHSGE-- 303
Cdd:COG5048  13 NSVLSSTPKST-LKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNps 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71051465 304 ---------------------------KPYICEECGKAFMYPYTLT--THKIIHTGEQPYK-----CKECDKAFNHPATL 349
Cdd:COG5048  92 dlnskslplsnskasssslsssssnsnDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLPgnnssSVNTPQSNSLHPPL 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71051465 350 S---------------SHKKIHTGEKPYTCDKCGKAFISSSILSKHEKIHTGEKPYKCEECGKAF----TRSSHLTMHKI 410
Cdd:COG5048 172 PanslskdpssnlsllISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpkslLSQSPSSLSSS 251

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71051465 411 IHTGEKPYKCEECG--KAFTWSAGLHKHRRTHTG-EKPYKCEECGKAYTTSSNLTEHK--TTHTGE--KPYKCKE--CGK 481
Cdd:COG5048 252 DSSSSASESPRSSLptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGK 331

                       330       340
                ....*....|....*....|..
gi 71051465 482 AFNWSSDLNKHKRIHIGQKKKK 503
Cdd:COG5048 332 LFSRNDALKRHILLHTSISPAK 353
zf-H2C2_2 pfam13465
Zinc-finger double domain;
377-401 2.44e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.44e-04
                          10        20
                  ....*....|....*....|....*
gi 71051465   377 LSKHEKIHTGEKPYKCEECGKAFTR 401
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
53-111 1.30e-30

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 113.07  E-value: 1.30e-30
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 71051465     53 LQFRDVAVEFSLEEWHCLDTAQQNLYRDVMLENYRHLVFLGIIVSKPDLITCLEQGIKP 111
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 55-93 7.67e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.21  E-value: 7.67e-21
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 71051465    55 FRDVAVEFSLEEWHCLDTAQQNLYRDVMLENYRHLVFLG 93
Cdd:pfam01352   4 FEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 55-92 2.36e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 78.36  E-value: 2.36e-18
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 71051465  55 FRDVAVEFSLEEWHCLDTAQQNLYRDVMLENYRHLVFL 92
Cdd:cd07765   3 FEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
228-503 3.54e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 3.54e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71051465 228 DKAFNQSSTHTtHKKIDTGEKPYKCEECGKAFNRSSHLTTHKITHTREKPYKC--EECGKVFKYFSSFTTHKKIHSGE-- 303
Cdd:COG5048  13 NSVLSSTPKST-LKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNps 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71051465 304 ---------------------------KPYICEECGKAFMYPYTLT--THKIIHTGEQPYK-----CKECDKAFNHPATL 349
Cdd:COG5048  92 dlnskslplsnskasssslsssssnsnDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLPgnnssSVNTPQSNSLHPPL 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71051465 350 S---------------SHKKIHTGEKPYTCDKCGKAFISSSILSKHEKIHTGEKPYKCEECGKAF----TRSSHLTMHKI 410
Cdd:COG5048 172 PanslskdpssnlsllISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpkslLSQSPSSLSSS 251

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71051465 411 IHTGEKPYKCEECG--KAFTWSAGLHKHRRTHTG-EKPYKCEECGKAYTTSSNLTEHK--TTHTGE--KPYKCKE--CGK 481
Cdd:COG5048 252 DSSSSASESPRSSLptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGK 331

                       330       340
                ....*....|....*....|..
gi 71051465 482 AFNWSSDLNKHKRIHIGQKKKK 503
Cdd:COG5048 332 LFSRNDALKRHILLHTSISPAK 353
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
360-497 3.35e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.78  E-value: 3.35e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71051465 360 KPYTCDKCGKAFISSSILSKH--EKIHTGE--KPYKCEE--CGKAFTRSSHLTMHKIIHTGEKPYKC--EECGKAFT--- 428
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSpll 367

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 71051465 429 --WSAGLHKHRRTHTGEKPYKCE--ECGKAYTTSSNLTEHKTTHTGEKP--YKCKECGKAFNWSSDLNKHKRIHI 497
Cdd:COG5048 368 nnEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
229-381 1.09e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.85  E-value: 1.09e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71051465 229 KAFNQSSTHTTHK--KIDTGE--KPYKCEE--CGKAFNRSSHLTTHKITHTREKPYKC--EECGKVFKYFS-----SFTT 295
Cdd:COG5048 297 ISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppQSLQ 376

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71051465 296 HKKIHSGEKPYICE--ECGKAFMYPYTLTTHKIIHTGEQP--YKCKECDKAFNHPATLSSHKKIHTGEKPYTCDKCGKAF 371
Cdd:COG5048 377 QYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456

                       170
                ....*....|
gi 71051465 372 ISSSILSKHE 381
Cdd:COG5048 457 RDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
232-425 4.67e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 4.67e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71051465 232 NQSSTHTTHKKIDTGEKPYkceeCGKAFNRSSHLTTHKITHTR-EKPYKCEECGKVFKYFSSFTTHK--KIHSGE--KPY 306
Cdd:COG5048 247 SLSSSDSSSSASESPRSSL----PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPF 322

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71051465 307 ICEE--CGKAFMYPYTLTTHKIIHTGEQPYKCK--ECDKAFN------HPATLSSHKKIHTGEKPYTCD-KCGKAFISSS 375
Cdd:COG5048 323 SCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSpllnnePPQSLQQYKDLKNDKKSETLSnSCIRNFKRDS 402

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 71051465 376 ILSKHEKIHTGEKP--YKCEECGKAFTRSSHLTMHKIIHTGEKPYKCEECGK 425
Cdd:COG5048 403 NLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 386-469 3.27e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.25  E-value: 3.27e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71051465 386 GEKPYKCE--ECGKAFTRSSHLTMHKiihtgekpyKCEECGKAFTWSAGLHKHRRTHTGEKPYKCEECGKAYTTSSNLTE 463
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                ....*.
gi 71051465 464 HKTTHT 469
Cdd:COG5189 417 HRKHSH 422
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 218-301 2.01e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 2.01e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71051465 218 EKKPlkyiEGDKAFNQSSTHTTHKKIDT--------GEKPYKCE--ECGKAFNRSSHLTTHK-------ITH-------- 272
Cdd:COG5189 314 RKLP----CTNSSSNGKLAHGGERNIDTpsrmlkvkDGKPYKCPveGCNKKYKNQNGLKYHMlhghqnqKLHenpspekm 389

                        90       100       110
                ....*....|....*....|....*....|...
gi 71051465 273 ----TREKPYKCEECGKVFKYFSSFTTHKKiHS 301
Cdd:COG5189 390 nifsAKDKPYRCEVCDKRYKNLNGLKYHRK-HS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
377-401 2.44e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.44e-04
                          10        20
                  ....*....|....*....|....*
gi 71051465   377 LSKHEKIHTGEKPYKCEECGKAFTR 401
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
460-484 4.23e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.23e-04
                          10        20
                  ....*....|....*....|....*
gi 71051465   460 NLTEHKTTHTGEKPYKCKECGKAFN 484
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
404-428 6.70e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.70e-04
                          10        20
                  ....*....|....*....|....*
gi 71051465   404 HLTMHKIIHTGEKPYKCEECGKAFT 428
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
349-373 1.02e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.02e-03
                          10        20
                  ....*....|....*....|....*
gi 71051465   349 LSSHKKIHTGEKPYTCDKCGKAFIS 373
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 414-493 1.22e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.22e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71051465 414 GEKPYKCE--ECGKAFTWSAGLHKHRrthtgekpyKCEECGKAYTTSSNLTEHKTTHTGEKPYKCKECGKAFNWSSDLNK 491
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                ..
gi 71051465 492 HK 493
Cdd:COG5189 417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
264-289 2.57e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.57e-03
                          10        20
                  ....*....|....*....|....*.
gi 71051465   264 HLTTHKITHTREKPYKCEECGKVFKY 289
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
435-457 2.81e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.81e-03
                          10        20
                  ....*....|....*....|...
gi 71051465   435 KHRRTHTGEKPYKCEECGKAYTT 457
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
321-345 3.23e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.23e-03
                          10        20
                  ....*....|....*....|....*
gi 71051465   321 LTTHKIIHTGEQPYKCKECDKAFNH 345
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 330-409 4.46e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 4.46e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71051465 330 GEQPYKCK--ECDKAFNHPATLSSHKKiHTGEKPYTCDKCGKafisssilSKHEKIHTGEKPYKCEECGKAFTRSSHLTM 407
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                ..
gi 71051465 408 HK 409
Cdd:COG5189 417 HR 418
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 250-272 6.45e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 6.45e-03
                          10        20
                  ....*....|....*....|...
gi 71051465   250 YKCEECGKAFNRSSHLTTHKITH 272
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 390-412 9.37e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 9.37e-03
                          10        20
                  ....*....|....*....|...
gi 71051465   390 YKCEECGKAFTRSSHLTMHKIIH 412
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH