NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|19484092|gb|AAH23442|]
View 

Transmembrane protein 219 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TMEM219 super family cl20824
Transmembrane 219; This protein belongs to a family found in eukaryotes. Proteins in this ...
 48-169 9.47e-11

Transmembrane 219; This protein belongs to a family found in eukaryotes. Proteins in this family are typically between 240 and 315 amino acids in length. The domains in this family vary in length from 202 to 249 amino acids. Its exact function remains unknown, however, it is thought to have a role as a transmembrane protein. More specifically, it is possible that this transmembrane protein may have a role as an insulin-like growth factor binding protein 3-receptor (IGFBP-3R). This receptor binds to the ligand, insulin growth factor 3, which is a p53-induced, apoptosis factor important for cancer prevention.


The actual alignment was detected with superfamily member pfam14940:

Pssm-ID: 464388  Cd Length: 236  Bit Score: 59.79  E-value: 9.47e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19484092    48 LRSPDIPQDWVSFLRSFGQLSLC----------------PMNETVTGTW--------QGPHVVGLLTTLNFGdGPDRNKT 103
Cdd:pfam14940  37 IKNPDITKDWNTFLLSFAELDFCvssnetlkhvledtspPESTHVVSTTlsasliniSVPIHLTLDPSDLFV-GYSPNVT 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19484092   104 qTFQAKIHGSQIGLTGSSAGESVLVT--------------ARVASGRTPGTCLYFSGVPKVLPSSQPPISCSEEGVGNAT 169
Cdd:pfam14940 116 -HLSATVSGSQLGLKGAAAKEEVNITftlpaawsssdvctGKHCEQVVFLTCVTFTAPAHVFPTTRQPPGCNPETVNVST 194
 
Name Accession Description Interval E-value
TMEM219 pfam14940
Transmembrane 219; This protein belongs to a family found in eukaryotes. Proteins in this ...
 48-169 9.47e-11

Transmembrane 219; This protein belongs to a family found in eukaryotes. Proteins in this family are typically between 240 and 315 amino acids in length. The domains in this family vary in length from 202 to 249 amino acids. Its exact function remains unknown, however, it is thought to have a role as a transmembrane protein. More specifically, it is possible that this transmembrane protein may have a role as an insulin-like growth factor binding protein 3-receptor (IGFBP-3R). This receptor binds to the ligand, insulin growth factor 3, which is a p53-induced, apoptosis factor important for cancer prevention.


Pssm-ID: 464388  Cd Length: 236  Bit Score: 59.79  E-value: 9.47e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19484092    48 LRSPDIPQDWVSFLRSFGQLSLC----------------PMNETVTGTW--------QGPHVVGLLTTLNFGdGPDRNKT 103
Cdd:pfam14940  37 IKNPDITKDWNTFLLSFAELDFCvssnetlkhvledtspPESTHVVSTTlsasliniSVPIHLTLDPSDLFV-GYSPNVT 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19484092   104 qTFQAKIHGSQIGLTGSSAGESVLVT--------------ARVASGRTPGTCLYFSGVPKVLPSSQPPISCSEEGVGNAT 169
Cdd:pfam14940 116 -HLSATVSGSQLGLKGAAAKEEVNITftlpaawsssdvctGKHCEQVVFLTCVTFTAPAHVFPTTRQPPGCNPETVNVST 194
 
Name Accession Description Interval E-value
TMEM219 pfam14940
Transmembrane 219; This protein belongs to a family found in eukaryotes. Proteins in this ...
 48-169 9.47e-11

Transmembrane 219; This protein belongs to a family found in eukaryotes. Proteins in this family are typically between 240 and 315 amino acids in length. The domains in this family vary in length from 202 to 249 amino acids. Its exact function remains unknown, however, it is thought to have a role as a transmembrane protein. More specifically, it is possible that this transmembrane protein may have a role as an insulin-like growth factor binding protein 3-receptor (IGFBP-3R). This receptor binds to the ligand, insulin growth factor 3, which is a p53-induced, apoptosis factor important for cancer prevention.


Pssm-ID: 464388  Cd Length: 236  Bit Score: 59.79  E-value: 9.47e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19484092    48 LRSPDIPQDWVSFLRSFGQLSLC----------------PMNETVTGTW--------QGPHVVGLLTTLNFGdGPDRNKT 103
Cdd:pfam14940  37 IKNPDITKDWNTFLLSFAELDFCvssnetlkhvledtspPESTHVVSTTlsasliniSVPIHLTLDPSDLFV-GYSPNVT 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19484092   104 qTFQAKIHGSQIGLTGSSAGESVLVT--------------ARVASGRTPGTCLYFSGVPKVLPSSQPPISCSEEGVGNAT 169
Cdd:pfam14940 116 -HLSATVSGSQLGLKGAAAKEEVNITftlpaawsssdvctGKHCEQVVFLTCVTFTAPAHVFPTTRQPPGCNPETVNVST 194
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH