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Conserved domains on  [gi|18605815|gb|AAH23059|]
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Loss of heterozygosity, 12, chromosomal region 1 homolog (human) [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BORCS5-like cd22789
BLOC-1-related complex subunit 5, and related proteins; This model includes BLOC-1-related ...
 30-186 4.95e-87

BLOC-1-related complex subunit 5, and related proteins; This model includes BLOC-1-related complex subunit 5 (BORCS5), which is also called loss of heterozygosity 12 chromosomal region 1 (LOH12CR1), myristoylated lysosomal protein, or myrlysin. BORCS5 is a component of BLOC-1 related complex (BORC), a multisubunit complex that also contains Lyspersin/C17orf59, Diaskedin/C10orf32, KxDL1, MEF2BNB, BLOS1, BLOS2, and Snapin subunits. BLOC-1 is important for the biogenesis of lysosome-related organelles, and BORC is important for the positioning of the lysosome in the cytoplasm. The BORC complex associates with the lysosomal membrane where it recruits the small GTPase Arl8, which leads in turn to the kinesin-dependent movement of lysosomes toward the plus ends of microtubules in the peripheral cytoplasm. LOH12CR1 may function as a tumor suppressor by inhibiting tumor growth through deregulation of the G1/S checkpoint in human colorectal carcinoma. It has been shown to bind to LKB1, a well-known tumor suppressor gene in colorectal cancer; its expression level could be used as a promising biomarker in patients. This domain has also been found in many hypothetical proteins involved in loss of heterozygosity and thus tumor suppression.


:

Pssm-ID: 439361  Cd Length: 157  Bit Score: 252.98  E-value: 4.95e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18605815  30 KMDDIVVVAQGSQASRNVSNDPDVIKLQEIPTFQPLLKGLLSGQTSPTNAKLEKLDSQQVLQLCLRYQDHLHQCAEAVAF 109
Cdd:cd22789   1 KMDDIVVVNEGTQSSRNVSNDPDLIKLQEIPTFLPLLKGSLNLPGSPDPEVLEKLDPRPLLKLCLRYQDHLRQCAEAVAF 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18605815 110 DQNALVKRIKEMDLSVETLFCFMQERQKRYAKYAEQIQKVNEMSAILRRIQMGIDQTVPLMERLNSMLPEAERLEPF 186
Cdd:cd22789  81 DQNALVKRIKEVDVEIASLSNSLQERQKRYAKYAEQLQKVNELSAQLNRIQMLLDQIVPLLERLNSLLPEEERLEPF 157
 
Name Accession Description Interval E-value
BORCS5-like cd22789
BLOC-1-related complex subunit 5, and related proteins; This model includes BLOC-1-related ...
 30-186 4.95e-87

BLOC-1-related complex subunit 5, and related proteins; This model includes BLOC-1-related complex subunit 5 (BORCS5), which is also called loss of heterozygosity 12 chromosomal region 1 (LOH12CR1), myristoylated lysosomal protein, or myrlysin. BORCS5 is a component of BLOC-1 related complex (BORC), a multisubunit complex that also contains Lyspersin/C17orf59, Diaskedin/C10orf32, KxDL1, MEF2BNB, BLOS1, BLOS2, and Snapin subunits. BLOC-1 is important for the biogenesis of lysosome-related organelles, and BORC is important for the positioning of the lysosome in the cytoplasm. The BORC complex associates with the lysosomal membrane where it recruits the small GTPase Arl8, which leads in turn to the kinesin-dependent movement of lysosomes toward the plus ends of microtubules in the peripheral cytoplasm. LOH12CR1 may function as a tumor suppressor by inhibiting tumor growth through deregulation of the G1/S checkpoint in human colorectal carcinoma. It has been shown to bind to LKB1, a well-known tumor suppressor gene in colorectal cancer; its expression level could be used as a promising biomarker in patients. This domain has also been found in many hypothetical proteins involved in loss of heterozygosity and thus tumor suppression.


Pssm-ID: 439361  Cd Length: 157  Bit Score: 252.98  E-value: 4.95e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18605815  30 KMDDIVVVAQGSQASRNVSNDPDVIKLQEIPTFQPLLKGLLSGQTSPTNAKLEKLDSQQVLQLCLRYQDHLHQCAEAVAF 109
Cdd:cd22789   1 KMDDIVVVNEGTQSSRNVSNDPDLIKLQEIPTFLPLLKGSLNLPGSPDPEVLEKLDPRPLLKLCLRYQDHLRQCAEAVAF 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18605815 110 DQNALVKRIKEMDLSVETLFCFMQERQKRYAKYAEQIQKVNEMSAILRRIQMGIDQTVPLMERLNSMLPEAERLEPF 186
Cdd:cd22789  81 DQNALVKRIKEVDVEIASLSNSLQERQKRYAKYAEQLQKVNELSAQLNRIQMLLDQIVPLLERLNSLLPEEERLEPF 157
LOH1CR12 pfam10158
Tumour suppressor protein; This is a region of 130 amino acids that is the most conserved ...
 61-191 6.91e-69

Tumour suppressor protein; This is a region of 130 amino acids that is the most conserved region of hypothetical proteins involved in loss of heterozygosity and thus tumour suppression. The exact function of family members is not known. This region is also found in subunit 5 of the BLOC-1-related complex, which is also found in the BORC complex. BLOC-1 is important for the biogenesis of lysosome-related organelles, and BORC is important for the positioning of the lysosome in the cytoplasm. The BORC complex associates with the lysosomal membrane where it recruits the small GTPase Arl8, which leads in turn to the kinesin-dependent movement of lysosomes toward the plus ends of microtubules in the peripheral cytoplasm.


Pssm-ID: 287167  Cd Length: 131  Bit Score: 206.20  E-value: 6.91e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18605815    61 TFQPLLKGLLSGQTSPTNAKLEKLDSQQVLQLCLRYQDHLHQCAEAVAFDQNALVKRIKEMDLSVETLFCFMQERQKRYA 140
Cdd:pfam10158   1 RFLPVLRGVISKRTNRTNETLEKLSSQHFINLCTRLQEHFNVCAKAVASDQNKIVARIKEVDASIITLFAETVAHQKQYA 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 18605815   141 KYAEQIQKVNEMSAILRRIQMGIDQTVPLMERLNSMLPEAERLEPFSMKPE 191
Cdd:pfam10158  81 SYAEQFSKVNQISDQLCRIQIILEQNVPSMETLNNILDPDERLEPFVWKPE 131
 
Name Accession Description Interval E-value
BORCS5-like cd22789
BLOC-1-related complex subunit 5, and related proteins; This model includes BLOC-1-related ...
 30-186 4.95e-87

BLOC-1-related complex subunit 5, and related proteins; This model includes BLOC-1-related complex subunit 5 (BORCS5), which is also called loss of heterozygosity 12 chromosomal region 1 (LOH12CR1), myristoylated lysosomal protein, or myrlysin. BORCS5 is a component of BLOC-1 related complex (BORC), a multisubunit complex that also contains Lyspersin/C17orf59, Diaskedin/C10orf32, KxDL1, MEF2BNB, BLOS1, BLOS2, and Snapin subunits. BLOC-1 is important for the biogenesis of lysosome-related organelles, and BORC is important for the positioning of the lysosome in the cytoplasm. The BORC complex associates with the lysosomal membrane where it recruits the small GTPase Arl8, which leads in turn to the kinesin-dependent movement of lysosomes toward the plus ends of microtubules in the peripheral cytoplasm. LOH12CR1 may function as a tumor suppressor by inhibiting tumor growth through deregulation of the G1/S checkpoint in human colorectal carcinoma. It has been shown to bind to LKB1, a well-known tumor suppressor gene in colorectal cancer; its expression level could be used as a promising biomarker in patients. This domain has also been found in many hypothetical proteins involved in loss of heterozygosity and thus tumor suppression.


Pssm-ID: 439361  Cd Length: 157  Bit Score: 252.98  E-value: 4.95e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18605815  30 KMDDIVVVAQGSQASRNVSNDPDVIKLQEIPTFQPLLKGLLSGQTSPTNAKLEKLDSQQVLQLCLRYQDHLHQCAEAVAF 109
Cdd:cd22789   1 KMDDIVVVNEGTQSSRNVSNDPDLIKLQEIPTFLPLLKGSLNLPGSPDPEVLEKLDPRPLLKLCLRYQDHLRQCAEAVAF 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18605815 110 DQNALVKRIKEMDLSVETLFCFMQERQKRYAKYAEQIQKVNEMSAILRRIQMGIDQTVPLMERLNSMLPEAERLEPF 186
Cdd:cd22789  81 DQNALVKRIKEVDVEIASLSNSLQERQKRYAKYAEQLQKVNELSAQLNRIQMLLDQIVPLLERLNSLLPEEERLEPF 157
LOH1CR12 pfam10158
Tumour suppressor protein; This is a region of 130 amino acids that is the most conserved ...
 61-191 6.91e-69

Tumour suppressor protein; This is a region of 130 amino acids that is the most conserved region of hypothetical proteins involved in loss of heterozygosity and thus tumour suppression. The exact function of family members is not known. This region is also found in subunit 5 of the BLOC-1-related complex, which is also found in the BORC complex. BLOC-1 is important for the biogenesis of lysosome-related organelles, and BORC is important for the positioning of the lysosome in the cytoplasm. The BORC complex associates with the lysosomal membrane where it recruits the small GTPase Arl8, which leads in turn to the kinesin-dependent movement of lysosomes toward the plus ends of microtubules in the peripheral cytoplasm.


Pssm-ID: 287167  Cd Length: 131  Bit Score: 206.20  E-value: 6.91e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18605815    61 TFQPLLKGLLSGQTSPTNAKLEKLDSQQVLQLCLRYQDHLHQCAEAVAFDQNALVKRIKEMDLSVETLFCFMQERQKRYA 140
Cdd:pfam10158   1 RFLPVLRGVISKRTNRTNETLEKLSSQHFINLCTRLQEHFNVCAKAVASDQNKIVARIKEVDASIITLFAETVAHQKQYA 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 18605815   141 KYAEQIQKVNEMSAILRRIQMGIDQTVPLMERLNSMLPEAERLEPFSMKPE 191
Cdd:pfam10158  81 SYAEQFSKVNQISDQLCRIQIILEQNVPSMETLNNILDPDERLEPFVWKPE 131
MEKK4_N pfam19431
MEKK4 N-terminal; This domain represents the regulatory N-terminal non-catalytic region of ...
 96-145 3.27e-04

MEKK4 N-terminal; This domain represents the regulatory N-terminal non-catalytic region of Mitogen-activated protein kinase kinase kinase 4 (MEKK4) which contains a putative PH-domain. This N-terminal region acts as an autoinhibitory domain that must be dissociated from the catalytic domain to allow the activation of these kinases.


Pssm-ID: 466077  Cd Length: 974  Bit Score: 40.68  E-value: 3.27e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 18605815    96 YQDHLHQcaEAVAFDQnalVKRIKEMDLSVETLFCFMQERQKRYAKYAEQ 145
Cdd:pfam19431 290 CREHLQR--QRVAFEQ---VKRVMELLEYVEALYPSLQALQKDYEKYAAK 334
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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