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Conserved domains on  [gi|116283292|gb|AAH18314|]
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TNPO2 protein, partial [Homo sapiens]

Protein Classification

importin beta family protein( domain architecture ID 707677)

importin beta family protein may function in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KAP95 super family cl27231
Karyopherin (importin) beta [Intracellular trafficking and secretion];
22-763 6.68e-20

Karyopherin (importin) beta [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5215:

Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 95.01  E-value: 6.68e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283292  22 SPNTATQRIVQDKLKQLNQ--FPDFNNYLIFVLTRLKSEDEpTRSLSGLILKNNVKAH-----------YQSFPPPVADF 88
Cdd:COG5215   16 SPDPNARLRAEAQLLELQSgdFEQFISLLVQVLCDLNSNDQ-LRMVAGLILKNSLHANdpelqkgcsqrWLGMRHESKEQ 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283292  89 IKQECLNNIGDASSLIRATIGILITTIASKgEL--QMWPELLPQLC-NLLNSEDYNTCEGAFGALQKICEDSsellDSDA 165
Cdd:COG5215   95 VKGMALRALKSPEPRFCTMAAQLLAAIARM-ELpnSLWPGLMEEMVrNVGDEQPVSGKCESLGICGYHCESE----APED 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283292 166 LNRPLNIMIPKFLQFFKHCSP--KIRSHAIACVNQFIMDrAQALMD---NIDTFIEHLFALAVDDDPEVRKNVCRALVML 240
Cdd:COG5215  170 LIQMSNVILFAIVMGALKNETtsAVRLAALKALMDSLMF-VQGNFCyeeERNYFMQVVCEATQGNDEELQHAAFGCLNKI 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283292 241 LEVRIDRLIPHMHSII-QYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDII--LLK 317
Cdd:COG5215  249 MMLYYKFMQSYMENALaALTGRFMKSQNDEVAIQAVEFWSTICEEEIDGEMEDKYLPEVPAQNHGFARAAVADVLpeLLS 328

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283292 318 GDVEEDeavPDSEQDIkprfhksrtvtlpheaerpdgsedaeddddddalsdWNLRKCSAAALDVLANVFREELLPHLLP 397
Cdd:COG5215  329 LLEKQG---EDYYGDD------------------------------------WNPSMAASSCLQLFAQLKGDKIMRPVLG 369

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283292 398 LLKGLLFHPEWVVKESGILVLGAIAEG-CMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYA-HWVVSQPPDMHL 475
Cdd:COG5215  370 FVEQNIRSESWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIAdHVAMIISPCGHL 449

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283292 476 KPLMTELLKRILDGNKRVqeAACS--------AFATLEEEACTELVPYLSYILDTLVFAFGKYQHKNLL--ILYDAIGTL 545
Cdd:COG5215  450 VLEVSASLIGLMDCPFRS--INCSwrkenlvdHIAKAVREVESFLAKFYLAILNALVKGTELALNESNLrvSLFSALGTL 527

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283292 546 ----ADSVGHHL-NQPEYIQKLMPPLIQ-KWNELKDEDKDLF-PLLECLSSVATALQSGFLPYCEPVYQRCVTLVQKTLA 618
Cdd:COG5215  528 ilicPDAVSDILaGFYDYTSKKLDECISvLGQILATEDQLLVeELQSNYIGVLEAIIRTRRRDIEDVEDQLMELFIRILE 607

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283292 619 QAMMYTQHPEQYEApdkdfmivaldlLSGLAEGLGGHVEQLVarSNIMTLLFQCMQDSMPEVRQSSFALLGDLTKACFIH 698
Cdd:COG5215  608 STKPTTAFGDVYTA------------ISALSTSLEERFEQYA--SKFIPYLTRALNCTDRFVLNSAVGLVGDLANTLGTD 673

                        730       740       750       760       770       780       790
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 116283292 699 VKPCIAEFM---------PILGTNLNPEFISVcnnatwaIGEICMQMGAEMQPYVQMVLNNLVEIINRPTPTQE 763
Cdd:COG5215  674 FNIYADVLMsslvqclssEATHRDLKPAILSV-------FGDIALAIGANFESYLDMIMMLFQQASELDPHSDE 740
 
Name Accession Description Interval E-value
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
22-763 6.68e-20

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 95.01  E-value: 6.68e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283292  22 SPNTATQRIVQDKLKQLNQ--FPDFNNYLIFVLTRLKSEDEpTRSLSGLILKNNVKAH-----------YQSFPPPVADF 88
Cdd:COG5215   16 SPDPNARLRAEAQLLELQSgdFEQFISLLVQVLCDLNSNDQ-LRMVAGLILKNSLHANdpelqkgcsqrWLGMRHESKEQ 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283292  89 IKQECLNNIGDASSLIRATIGILITTIASKgEL--QMWPELLPQLC-NLLNSEDYNTCEGAFGALQKICEDSsellDSDA 165
Cdd:COG5215   95 VKGMALRALKSPEPRFCTMAAQLLAAIARM-ELpnSLWPGLMEEMVrNVGDEQPVSGKCESLGICGYHCESE----APED 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283292 166 LNRPLNIMIPKFLQFFKHCSP--KIRSHAIACVNQFIMDrAQALMD---NIDTFIEHLFALAVDDDPEVRKNVCRALVML 240
Cdd:COG5215  170 LIQMSNVILFAIVMGALKNETtsAVRLAALKALMDSLMF-VQGNFCyeeERNYFMQVVCEATQGNDEELQHAAFGCLNKI 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283292 241 LEVRIDRLIPHMHSII-QYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDII--LLK 317
Cdd:COG5215  249 MMLYYKFMQSYMENALaALTGRFMKSQNDEVAIQAVEFWSTICEEEIDGEMEDKYLPEVPAQNHGFARAAVADVLpeLLS 328

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283292 318 GDVEEDeavPDSEQDIkprfhksrtvtlpheaerpdgsedaeddddddalsdWNLRKCSAAALDVLANVFREELLPHLLP 397
Cdd:COG5215  329 LLEKQG---EDYYGDD------------------------------------WNPSMAASSCLQLFAQLKGDKIMRPVLG 369

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283292 398 LLKGLLFHPEWVVKESGILVLGAIAEG-CMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYA-HWVVSQPPDMHL 475
Cdd:COG5215  370 FVEQNIRSESWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIAdHVAMIISPCGHL 449

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283292 476 KPLMTELLKRILDGNKRVqeAACS--------AFATLEEEACTELVPYLSYILDTLVFAFGKYQHKNLL--ILYDAIGTL 545
Cdd:COG5215  450 VLEVSASLIGLMDCPFRS--INCSwrkenlvdHIAKAVREVESFLAKFYLAILNALVKGTELALNESNLrvSLFSALGTL 527

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283292 546 ----ADSVGHHL-NQPEYIQKLMPPLIQ-KWNELKDEDKDLF-PLLECLSSVATALQSGFLPYCEPVYQRCVTLVQKTLA 618
Cdd:COG5215  528 ilicPDAVSDILaGFYDYTSKKLDECISvLGQILATEDQLLVeELQSNYIGVLEAIIRTRRRDIEDVEDQLMELFIRILE 607

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283292 619 QAMMYTQHPEQYEApdkdfmivaldlLSGLAEGLGGHVEQLVarSNIMTLLFQCMQDSMPEVRQSSFALLGDLTKACFIH 698
Cdd:COG5215  608 STKPTTAFGDVYTA------------ISALSTSLEERFEQYA--SKFIPYLTRALNCTDRFVLNSAVGLVGDLANTLGTD 673

                        730       740       750       760       770       780       790
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 116283292 699 VKPCIAEFM---------PILGTNLNPEFISVcnnatwaIGEICMQMGAEMQPYVQMVLNNLVEIINRPTPTQE 763
Cdd:COG5215  674 FNIYADVLMsslvqclssEATHRDLKPAILSV-------FGDIALAIGANFESYLDMIMMLFQQASELDPHSDE 740
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 408-462 2.14e-14

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 68.16  E-value: 2.14e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 116283292  408 WVVKESGILVLGAIAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRY 462
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
 36-99 2.46e-08

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 51.09  E-value: 2.46e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 116283292    36 KQLNQFPDFNNYLIFVLTRL-KSEDEPTRSLSGLILKNNVKAHYQSFPPPVADFIKQECLNNIGD 99
Cdd:smart00913   3 KQLEQFQKSPGFWLLLLEILaNSEDQYVRQLAAITLKNKITRRWSSLPEEEKEEIKNSLLELLLS 67
 
Name Accession Description Interval E-value
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
22-763 6.68e-20

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 95.01  E-value: 6.68e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283292  22 SPNTATQRIVQDKLKQLNQ--FPDFNNYLIFVLTRLKSEDEpTRSLSGLILKNNVKAH-----------YQSFPPPVADF 88
Cdd:COG5215   16 SPDPNARLRAEAQLLELQSgdFEQFISLLVQVLCDLNSNDQ-LRMVAGLILKNSLHANdpelqkgcsqrWLGMRHESKEQ 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283292  89 IKQECLNNIGDASSLIRATIGILITTIASKgEL--QMWPELLPQLC-NLLNSEDYNTCEGAFGALQKICEDSsellDSDA 165
Cdd:COG5215   95 VKGMALRALKSPEPRFCTMAAQLLAAIARM-ELpnSLWPGLMEEMVrNVGDEQPVSGKCESLGICGYHCESE----APED 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283292 166 LNRPLNIMIPKFLQFFKHCSP--KIRSHAIACVNQFIMDrAQALMD---NIDTFIEHLFALAVDDDPEVRKNVCRALVML 240
Cdd:COG5215  170 LIQMSNVILFAIVMGALKNETtsAVRLAALKALMDSLMF-VQGNFCyeeERNYFMQVVCEATQGNDEELQHAAFGCLNKI 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283292 241 LEVRIDRLIPHMHSII-QYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDII--LLK 317
Cdd:COG5215  249 MMLYYKFMQSYMENALaALTGRFMKSQNDEVAIQAVEFWSTICEEEIDGEMEDKYLPEVPAQNHGFARAAVADVLpeLLS 328

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283292 318 GDVEEDeavPDSEQDIkprfhksrtvtlpheaerpdgsedaeddddddalsdWNLRKCSAAALDVLANVFREELLPHLLP 397
Cdd:COG5215  329 LLEKQG---EDYYGDD------------------------------------WNPSMAASSCLQLFAQLKGDKIMRPVLG 369

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283292 398 LLKGLLFHPEWVVKESGILVLGAIAEG-CMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYA-HWVVSQPPDMHL 475
Cdd:COG5215  370 FVEQNIRSESWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIAdHVAMIISPCGHL 449

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283292 476 KPLMTELLKRILDGNKRVqeAACS--------AFATLEEEACTELVPYLSYILDTLVFAFGKYQHKNLL--ILYDAIGTL 545
Cdd:COG5215  450 VLEVSASLIGLMDCPFRS--INCSwrkenlvdHIAKAVREVESFLAKFYLAILNALVKGTELALNESNLrvSLFSALGTL 527

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283292 546 ----ADSVGHHL-NQPEYIQKLMPPLIQ-KWNELKDEDKDLF-PLLECLSSVATALQSGFLPYCEPVYQRCVTLVQKTLA 618
Cdd:COG5215  528 ilicPDAVSDILaGFYDYTSKKLDECISvLGQILATEDQLLVeELQSNYIGVLEAIIRTRRRDIEDVEDQLMELFIRILE 607

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283292 619 QAMMYTQHPEQYEApdkdfmivaldlLSGLAEGLGGHVEQLVarSNIMTLLFQCMQDSMPEVRQSSFALLGDLTKACFIH 698
Cdd:COG5215  608 STKPTTAFGDVYTA------------ISALSTSLEERFEQYA--SKFIPYLTRALNCTDRFVLNSAVGLVGDLANTLGTD 673

                        730       740       750       760       770       780       790
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 116283292 699 VKPCIAEFM---------PILGTNLNPEFISVcnnatwaIGEICMQMGAEMQPYVQMVLNNLVEIINRPTPTQE 763
Cdd:COG5215  674 FNIYADVLMsslvqclssEATHRDLKPAILSV-------FGDIALAIGANFESYLDMIMMLFQQASELDPHSDE 740
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 408-462 2.14e-14

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 68.16  E-value: 2.14e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 116283292  408 WVVKESGILVLGAIAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRY 462
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
IBN_N pfam03810
Importin-beta N-terminal domain;
32-99 1.58e-10

Importin-beta N-terminal domain;


Pssm-ID: 397745 [Multi-domain]  Cd Length: 72  Bit Score: 57.63  E-value: 1.58e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 116283292   32 QDKLKQLNQFPDFNNYLIFVLTRLKSeDEPTRSLSGLILKNNVKAHYQ----SFPPPVADFIKQECLNNIGD 99
Cdd:pfam03810   2 EKQLEQFEKSPGFWSKLLQILSNSEN-PLEVRQLAALYLKNLITRHWEeeknSLPPEEKEQIKNNLLNLLGS 72
CSE1 COG5657
CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]; ...
 21-186 1.72e-08

CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning];


Pssm-ID: 227944 [Multi-domain]  Cd Length: 947  Bit Score: 58.28  E-value: 1.72e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283292  21 QSPNTATQRIVQDKLKQLNQFPDFNnYLIFVLTRLKSEDEPTRSLSGLILKNNVKAHY-----QSFPPPVADFIKQECLN 95
Cdd:COG5657   14 QSPDPPSVKCAEERLRQWEKQHGFA-LKLLSINLSAFNSMSLRWAALIQFKNYIDKHWreengNSILPDENVLIRDELFS 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283292  96 NIGDASSLIRATIGILITTIASKGELQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDALNRPLNIMIP 175
Cdd:COG5657   93 LIISSSNQLQIQNALAVSRIARLDFPDEWPTLVPDLLSLLSEKDMVTNENSLRVLHHIFKRLRRLFRSDALFLEIAPVLL 172

                        170
                 ....*....|.
gi 116283292 176 KFLQFFKHCSP 186
Cdd:COG5657  173 SILCPFLFSSA 183
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
 36-99 2.46e-08

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 51.09  E-value: 2.46e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 116283292    36 KQLNQFPDFNNYLIFVLTRL-KSEDEPTRSLSGLILKNNVKAHYQSFPPPVADFIKQECLNNIGD 99
Cdd:smart00913   3 KQLEQFQKSPGFWLLLLEILaNSEDQYVRQLAAITLKNKITRRWSSLPEEEKEEIKNSLLELLLS 67
HEAT COG1413
HEAT repeat [General function prediction only];
125-276 3.49e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 44.23  E-value: 3.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283292 125 PELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSelldsdalnrplnimIPKFLQFFKHCSPKIRSHAIACVNQFIMDRA 204
Cdd:COG1413   15 PAAVPALIAALADEDPDVRAAAARALGRLGDPRA---------------VPALLEALKDPDPEVRAAAAEALGRIGDPEA 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 116283292 205 qalmdnidtfIEHLFALAVDDDPEVRKNVCRALVMLLEVRidrliphmhsIIQYMLQRTQDHDENVALEACE 276
Cdd:COG1413   80 ----------VPALIAALKDEDPEVRRAAAEALGRLGDPA----------AVPALLEALKDPDWEVRRAAAR 131
HEAT COG1413
HEAT repeat [General function prediction only];
410-580 5.74e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 40.77  E-value: 5.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283292 410 VKESGILVLGAIAEgcmqgmvpylPELIPHLIQCLSDKKALVRSIACWTLSRyahwvvsqppdMHLKPLMTELLKRILDG 489
Cdd:COG1413    1 VRRAAARALGRLGD----------PAAVPALIAALADEDPDVRAAAARALGR-----------LGDPRAVPALLEALKDP 59

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283292 490 NKRVQEAACSAFATL-EEEACTELVPYLsyildtlvfafgkyQHKNLLILYDAIGTLAdsvghHLNQPEYIqklmPPLIQ 568
Cdd:COG1413   60 DPEVRAAAAEALGRIgDPEAVPALIAAL--------------KDEDPEVRRAAAEALG-----RLGDPAAV----PALLE 116

                        170
                 ....*....|..
gi 116283292 569 KwneLKDEDKDL 580
Cdd:COG1413  117 A---LKDPDWEV 125
HEAT COG1413
HEAT repeat [General function prediction only];
377-517 3.46e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 38.46  E-value: 3.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116283292 377 AAALDVLANVFREELLPHLLPLLKgllfHPEWVVKESGILVLGAIAEgcmqgmvpylPELIPHLIQCLSDKKALVRSIAC 456
Cdd:COG1413    3 RAAARALGRLGDPAAVPALIAALA----DEDPDVRAAAARALGRLGD----------PRAVPALLEALKDPDPEVRAAAA 68

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 116283292 457 WTLSRYAhwvvsqppDMHLKPLMTELLKrilDGNKRVQEAACSAFATL-EEEACTELVPYLS 517
Cdd:COG1413   69 EALGRIG--------DPEAVPALIAALK---DEDPEVRRAAAEALGRLgDPAAVPALLEALK 119
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 186-237 4.77e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 35.81  E-value: 4.77e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 116283292  186 PKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRAL 237
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWAL 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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