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Conserved domains on  [gi|15489339|gb|AAH13767|]
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VASN protein, partial [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-223 2.00e-21

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.93  E-value: 2.00e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15489339   1 AGLPGLQLLDLSQNQIASLPSGVFQpLANLSNLDLTANRLHEItNETFRGLRRLERLYLGKNRIRHIqPGAFDTLDRLLE 80
Cdd:COG4886 110 SNLTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKE 186

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15489339  81 LKLqdnelralpplrlprlllldlSHNSLLALEPGILDTANVEALRLAGLGLQQLDEGLfSRLRNLHDLDVSDNQLERVp 160
Cdd:COG4886 187 LDL---------------------SNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDL- 243

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15489339 161 PVIRGLRGLTRLRLAGNtRIAQLRPedLAGLAALQELDVSN-----LSLQALPGDLSGLFPRLRLLAA 223
Cdd:COG4886 244 PELGNLTNLEELDLSNN-QLTDLPP--LANLTNLKTLDLSNnqltdLKLKELELLLGLNSLLLLLLLL 308
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 198-277 4.88e-07

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 53.16  E-value: 4.88e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15489339    198 DVSNLSLQALPgdlSGLFPRLRLLAA---ARNPFNCVCPLSWFGPWVRESHVTLASPEETRCHFPPKNAGRLLLELDYAD 274
Cdd:TIGR00864    1 DISNNKISTIE---EGICANLCNLSEidlSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGIPLLD 77


                   ...
gi 15489339    275 FGC 277
Cdd:TIGR00864   78 SGC 80
fn3 pfam00041
Fibronectin type III domain;
394-463 4.34e-06

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 45.10  E-value: 4.34e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15489339   394 LGIEPVSPTSLRVGLQRYLQGSSVqLRSLRLTYRNLSGPDkRLVTLRLPASLAEYTVTQLRPNATYSVCV 463
Cdd:pfam00041   6 LTVTDVTSTSLTVSWTPPPDGNGP-ITGYEVEYRPKNSGE-PWNEITVPGTTTSVTLTGLKPGTEYEVRV 73
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 337-368 1.38e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.98  E-value: 1.38e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 15489339   337 CPPSTCLNGGTC-HLGTRHHlaCLCPEGFTGLY 368
Cdd:pfam00008   1 CAPNPCSNGGTCvDTPGGYT--CICPEGYTGKR 31
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-223 2.00e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.93  E-value: 2.00e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15489339   1 AGLPGLQLLDLSQNQIASLPSGVFQpLANLSNLDLTANRLHEItNETFRGLRRLERLYLGKNRIRHIqPGAFDTLDRLLE 80
Cdd:COG4886 110 SNLTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKE 186

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15489339  81 LKLqdnelralpplrlprlllldlSHNSLLALEPGILDTANVEALRLAGLGLQQLDEGLfSRLRNLHDLDVSDNQLERVp 160
Cdd:COG4886 187 LDL---------------------SNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDL- 243

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15489339 161 PVIRGLRGLTRLRLAGNtRIAQLRPedLAGLAALQELDVSN-----LSLQALPGDLSGLFPRLRLLAA 223
Cdd:COG4886 244 PELGNLTNLEELDLSNN-QLTDLPP--LANLTNLKTLDLSNnqltdLKLKELELLLGLNSLLLLLLLL 308
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 4-177 1.08e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 73.28  E-value: 1.08e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15489339   4 PGLQLLDLSQNQIASLPSgvFQPLANLSNLDLTANRLHEITNetFRGLRRLERLYLGKNRIRHIQpgAFDTLDRLLELKL 83
Cdd:cd21340  24 KNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVE--GLENLTNLEELHI 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15489339  84 QDNELRAlpplrlprlllldlshNSLLALEPGILDT--ANVEALRLAGLGLQQLDEglFSRLRNLHDLDVSDNQL---ER 158
Cdd:cd21340  98 ENQRLPP----------------GEKLTFDPRSLAAlsNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQIsdlEE 159

                       170
                ....*....|....*....
gi 15489339 159 VPPVIRGLRGLTRLRLAGN 177
Cdd:cd21340 160 LLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
29-86 5.65e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.00  E-value: 5.65e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 15489339    29 NLSNLDLTANRLHEITNETFRGLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDN 86
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 198-277 4.88e-07

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 53.16  E-value: 4.88e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15489339    198 DVSNLSLQALPgdlSGLFPRLRLLAA---ARNPFNCVCPLSWFGPWVRESHVTLASPEETRCHFPPKNAGRLLLELDYAD 274
Cdd:TIGR00864    1 DISNNKISTIE---EGICANLCNLSEidlSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGIPLLD 77


                   ...
gi 15489339    275 FGC 277
Cdd:TIGR00864   78 SGC 80
LRRCT smart00082
Leucine rich repeat C-terminal domain;
226-277 1.05e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 45.88  E-value: 1.05e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 15489339    226 NPFNCVCPLSWFGPWVRESHVTLaSPEETRCHFPPKNAGRlLLELDYADFGC 277
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQ-DPVDLRCASPSSLRGP-LLELLHSEFKC 50
fn3 pfam00041
Fibronectin type III domain;
394-463 4.34e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 45.10  E-value: 4.34e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15489339   394 LGIEPVSPTSLRVGLQRYLQGSSVqLRSLRLTYRNLSGPDkRLVTLRLPASLAEYTVTQLRPNATYSVCV 463
Cdd:pfam00041   6 LTVTDVTSTSLTVSWTPPPDGNGP-ITGYEVEYRPKNSGE-PWNEITVPGTTTSVTLTGLKPGTEYEVRV 73
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 337-368 1.38e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.98  E-value: 1.38e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 15489339   337 CPPSTCLNGGTC-HLGTRHHlaCLCPEGFTGLY 368
Cdd:pfam00008   1 CAPNPCSNGGTCvDTPGGYT--CICPEGYTGKR 31
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 3-87 7.08e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.99  E-value: 7.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15489339    3 LPGLQLLDLSQNQI-ASLPSgvFQPLANLSNLDLTANRLHEITNETFRGLRRLERLYLGKNRIRHIQPGAFDTLDRLLEL 81
Cdd:PLN00113 451 MPSLQMLSLARNKFfGGLPD--SFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSL 528


                 ....*.
gi 15489339   82 KLQDNE 87
Cdd:PLN00113 529 DLSHNQ 534
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 336-370 5.56e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 5.56e-04
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 15489339 336 DC-PPSTCLNGGTCH--LGTRHhlaCLCPEGFTGLYCE 370
Cdd:cd00054   4 ECaSGNPCQNGGTCVntVGSYR---CSCPPGYTGRNCE 38
LRR smart00370
Leucine-rich repeats, outliers;
3-26 1.13e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 36.56  E-value: 1.13e-03
                           10        20
                   ....*....|....*....|....
gi 15489339      3 LPGLQLLDLSQNQIASLPSGVFQP 26
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-223 2.00e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.93  E-value: 2.00e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15489339   1 AGLPGLQLLDLSQNQIASLPSGVFQpLANLSNLDLTANRLHEItNETFRGLRRLERLYLGKNRIRHIqPGAFDTLDRLLE 80
Cdd:COG4886 110 SNLTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKE 186

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15489339  81 LKLqdnelralpplrlprlllldlSHNSLLALEPGILDTANVEALRLAGLGLQQLDEGLfSRLRNLHDLDVSDNQLERVp 160
Cdd:COG4886 187 LDL---------------------SNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDL- 243

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15489339 161 PVIRGLRGLTRLRLAGNtRIAQLRPedLAGLAALQELDVSN-----LSLQALPGDLSGLFPRLRLLAA 223
Cdd:COG4886 244 PELGNLTNLEELDLSNN-QLTDLPP--LANLTNLKTLDLSNnqltdLKLKELELLLGLNSLLLLLLLL 308
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-272 5.87e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 92.69  E-value: 5.87e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15489339   1 AGLPGLQLLDLSQNQIaslpsgvFQPLANLSNLDLTANRLHEITNEtFRGLRRLERLYLGKNRIRHIqPGAFDTLDRLLE 80
Cdd:COG4886  93 GDLTNLTELDLSGNEE-------LSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDL-PEPLGNLTNLKS 163

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15489339  81 LKLqdnelralpplrlprlllldlSHNSLLALEPGILDTANVEALRLAGLGLQQLDEGLfSRLRNLHDLDVSDNQLERVP 160
Cdd:COG4886 164 LDL---------------------SNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPL-GNLTNLEELDLSGNQLTDLP 221

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15489339 161 PVIRGLRGLTRLRLAGNtRIAQLrpEDLAGLAALQELDVSNLSLQALPGdlSGLFPRLRLLAAARNPFNCVCPLSWFGPW 240
Cdd:COG4886 222 EPLANLTNLETLDLSNN-QLTDL--PELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLL 296

                       250       260       270
                ....*....|....*....|....*....|..
gi 15489339 241 VRESHVTLASPEETRCHFPPKNAGRLLLELDY 272
Cdd:COG4886 297 GLNSLLLLLLLLNLLELLILLLLLTTLLLLLL 328
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 4-177 1.08e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 73.28  E-value: 1.08e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15489339   4 PGLQLLDLSQNQIASLPSgvFQPLANLSNLDLTANRLHEITNetFRGLRRLERLYLGKNRIRHIQpgAFDTLDRLLELKL 83
Cdd:cd21340  24 KNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVE--GLENLTNLEELHI 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15489339  84 QDNELRAlpplrlprlllldlshNSLLALEPGILDT--ANVEALRLAGLGLQQLDEglFSRLRNLHDLDVSDNQL---ER 158
Cdd:cd21340  98 ENQRLPP----------------GEKLTFDPRSLAAlsNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQIsdlEE 159

                       170
                ....*....|....*....
gi 15489339 159 VPPVIRGLRGLTRLRLAGN 177
Cdd:cd21340 160 LLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
29-86 5.65e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.00  E-value: 5.65e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 15489339    29 NLSNLDLTANRLHEITNETFRGLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDN 86
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
4-64 9.76e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 9.76e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15489339     4 PGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETFRGLRRLERLYLGKNRI 64
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-157 2.66e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.48  E-value: 2.66e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15489339   1 AGLPGLQLLDLSQNQIASLPSgvFQPLANLSNLDLTANRLHEITNETfrGLRRLERLYLGKNRIRHIQPGAFDTLDRLLE 80
Cdd:COG4886 225 ANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNS 300

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15489339  81 LKLQDNELRALPPLRLPRLLLLDLSHNSLLALEPGILDTANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLE 157
Cdd:COG4886 301 LLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEA 377
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 198-277 4.88e-07

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 53.16  E-value: 4.88e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15489339    198 DVSNLSLQALPgdlSGLFPRLRLLAA---ARNPFNCVCPLSWFGPWVRESHVTLASPEETRCHFPPKNAGRLLLELDYAD 274
Cdd:TIGR00864    1 DISNNKISTIE---EGICANLCNLSEidlSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGIPLLD 77


                   ...
gi 15489339    275 FGC 277
Cdd:TIGR00864   78 SGC 80
LRRCT smart00082
Leucine rich repeat C-terminal domain;
226-277 1.05e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 45.88  E-value: 1.05e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 15489339    226 NPFNCVCPLSWFGPWVRESHVTLaSPEETRCHFPPKNAGRlLLELDYADFGC 277
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQ-DPVDLRCASPSSLRGP-LLELLHSEFKC 50
LRR_8 pfam13855
Leucine rich repeat;
2-40 1.45e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 1.45e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 15489339     2 GLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRL 40
Cdd:pfam13855  23 GLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 27-228 3.88e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.24  E-value: 3.88e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15489339  27 LANLSNLDLTANRLHEITNetFRGLRRLERLYLGKNRIRHIQpgAFDTLDRLLELKLQdnelralpplrlprlllldlsH 106
Cdd:cd21340   1 LKRITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQ---------------------N 55

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15489339 107 NSLLALEpgildtaNVEALRLaglgLQQLD---------EGLfSRLRNLHDLDVSDNQLERVPPV------IRGLRG-LT 170
Cdd:cd21340  56 NQIEKIE-------NLENLVN----LKKLYlggnrisvvEGL-ENLTNLEELHIENQRLPPGEKLtfdprsLAALSNsLR 123

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15489339 171 RLRLAGNtRIAQLrpEDLAGLAALQELDVSN---LSLQALPGDLSGLfPRLRLLAAARNPF 228
Cdd:cd21340 124 VLNISGN-NIDSL--EPLAPLRNLEQLDASNnqiSDLEELLDLLSSW-PSLRELDLTGNPV 180
fn3 pfam00041
Fibronectin type III domain;
394-463 4.34e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 45.10  E-value: 4.34e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15489339   394 LGIEPVSPTSLRVGLQRYLQGSSVqLRSLRLTYRNLSGPDkRLVTLRLPASLAEYTVTQLRPNATYSVCV 463
Cdd:pfam00041   6 LTVTDVTSTSLTVSWTPPPDGNGP-ITGYEVEYRPKNSGE-PWNEITVPGTTTSVTLTGLKPGTEYEVRV 73
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 337-368 1.38e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.98  E-value: 1.38e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 15489339   337 CPPSTCLNGGTC-HLGTRHHlaCLCPEGFTGLY 368
Cdd:pfam00008   1 CAPNPCSNGGTCvDTPGGYT--CICPEGYTGKR 31
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 3-87 7.08e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.99  E-value: 7.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15489339    3 LPGLQLLDLSQNQI-ASLPSgvFQPLANLSNLDLTANRLHEITNETFRGLRRLERLYLGKNRIRHIQPGAFDTLDRLLEL 81
Cdd:PLN00113 451 MPSLQMLSLARNKFfGGLPD--SFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSL 528


                 ....*.
gi 15489339   82 KLQDNE 87
Cdd:PLN00113 529 DLSHNQ 534
LRR_8 pfam13855
Leucine rich repeat;
52-156 7.38e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 7.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15489339    52 RRLERLYLGKNRIRHIQPGAFDTLDRLLELKLqdnelralpplrlprlllldlSHNSllalepgildtanvealrlaglg 131
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDL---------------------SNNL----------------------- 36

                          90       100
                  ....*....|....*....|....*
gi 15489339   132 LQQLDEGLFSRLRNLHDLDVSDNQL 156
Cdd:pfam13855  37 LTTLSPGAFSGLPSLRYLDLSGNRL 61
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 336-370 5.56e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 5.56e-04
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 15489339 336 DC-PPSTCLNGGTCH--LGTRHhlaCLCPEGFTGLYCE 370
Cdd:cd00054   4 ECaSGNPCQNGGTCVntVGSYR---CSCPPGYTGRNCE 38
LRR smart00370
Leucine-rich repeats, outliers;
3-26 1.13e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 36.56  E-value: 1.13e-03
                           10        20
                   ....*....|....*....|....
gi 15489339      3 LPGLQLLDLSQNQIASLPSGVFQP 26
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
3-26 1.13e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 36.56  E-value: 1.13e-03
                           10        20
                   ....*....|....*....|....
gi 15489339      3 LPGLQLLDLSQNQIASLPSGVFQP 26
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
1-229 1.64e-03

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 41.61  E-value: 1.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15489339    1 AGLPG-LQLLDLSQNQIASLPSGVfqPLAnLSNLDLTANRLHEITNETFRGLRRLErLYlgKNRIR----HIQPGafdtl 75
Cdd:PRK15370 237 ATLPDtIQEMELSINRITELPERL--PSA-LQSLDLFHNKISCLPENLPEELRYLS-VY--DNSIRtlpaHLPSG----- 305

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15489339   76 drLLELKLQDNELralpplrlprlllldlshNSLLALEPgildtANVEALRLAGLGLQQLDEGLFSRLRNlhdLDVSDNQ 155
Cdd:PRK15370 306 --ITHLNVQSNSL------------------TALPETLP-----PGLKTLEAGENALTSLPASLPPELQV---LDVSKNQ 357

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15489339  156 L----ERVPPVIrglrglTRLRLAGNTRIAqlRPEDLAglAALQELDVSNLSLQALPGDLSGLF---PRLRLLAAARNPF 228
Cdd:PRK15370 358 ItvlpETLPPTI------TTLDVSRNALTN--LPENLP--AALQIMQASRNNLVRLPESLPHFRgegPQPTRIIVEYNPF 427


                 .
gi 15489339  229 N 229
Cdd:PRK15370 428 S 428
LRR_8 pfam13855
Leucine rich repeat;
167-228 1.65e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 1.65e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15489339   167 RGLTRLRLAGNtRIAQLRPEDLAGLAALQELDVSNLSLQAL-PGDLSGLfPRLRLLAAARNPF 228
Cdd:pfam13855   1 PNLRSLDLSNN-RLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGL-PSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 145-185 1.96e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 1.96e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 15489339   145 NLHDLDVSDNQLERVPPvIRGLRGLTRLRLAGNTRIAQLRP 185
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP-LAKLPNLETLDLSGNNKITDLSD 41
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 27-228 2.52e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.99  E-value: 2.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15489339   27 LANLSNLDLTANRLHEITNETFRGLRRLERLYLGKNRIR-HIQPGAFDtLDRLLELKLQDNELRALPPLRLPRLLLLDLS 105
Cdd:PLN00113 235 LTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFS-LQKLISLDLSDNSLSGEIPELVIQLQNLEIL 313

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15489339  106 H---NSLLALEPGILDT-ANVEALRL----------AGLGLQ---------------QLDEGLFSRlRNLHDLDVSDNQL 156
Cdd:PLN00113 314 HlfsNNFTGKIPVALTSlPRLQVLQLwsnkfsgeipKNLGKHnnltvldlstnnltgEIPEGLCSS-GNLFKLILFSNSL 392

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15489339  157 E-RVPPVIRGLRGLTRLRLAGNTRIAQLrPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRLLAAARNPF 228
Cdd:PLN00113 393 EgEIPKSLGACRSLRRVRLQDNSFSGEL-PSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKF 464
PLN03150 PLN03150
hypothetical protein; Provisional
 122-229 2.66e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.57  E-value: 2.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15489339  122 VEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLE-RVPPVIRGLRGLTRLRLAGNtRIAQLRPEDLAGLAALQELDVS 200
Cdd:PLN03150 420 IDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYN-SFNGSIPESLGQLTSLRILNLN 498

                         90       100       110
                 ....*....|....*....|....*....|
gi 15489339  201 NLSLQA-LPGDLSGlfprlRLLAAARnpFN 229
Cdd:PLN03150 499 GNSLSGrVPAALGG-----RLLHRAS--FN 521
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
107-228 3.35e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.30  E-value: 3.35e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15489339 107 NSLLALEPGILDTANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERVPPVIRGLRGLTRLRLAGNtriaqlrpE 186
Cdd:COG4886  36 ALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN--------E 107

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 15489339 187 DLAGLAALQELDVSNLSLQALPGDLSGLfPRLRLLAAARNPF 228
Cdd:COG4886 108 ELSNLTNLESLDLSGNQLTDLPEELANL-TNLKELDLSNNQL 148
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 4-40 7.00e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 7.00e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 15489339     4 PGLQLLDLSQNQIASLPSgvFQPLANLSNLDLTANRL 40
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNNK 35
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 342-364 9.88e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 33.85  E-value: 9.88e-03
                          10        20
                  ....*....|....*....|...
gi 15489339   342 CLNGGTCHLGTRHHLaCLCPEGF 364
Cdd:pfam12661   1 CQNGGTCVDGVNGYK-CQCPPGY 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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