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Conserved domains on  [gi|22800617|gb|AAH13114|]
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AarF domain containing kinase 4 [Homo sapiens]

Protein Classification

ABC1 kinase family protein( domain architecture ID 10195515)

ABC1 (activator of bc1 complex) kinase family protein is an atypical protein kinase belonging to the protein kinase superfamily, similar to the atypical kinases COQ8A and COQ8B, which are involved in the biosynthesis of coenzyme Q (ubiquinone)

CATH:  1.10.510.10
EC:  2.7.-.-
Gene Ontology:  GO:0016301|GO:0016310|GO:0005524
PubMed:  16244704

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ABC1_ADCK3 cd13970
Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3; This ...
175-424 3.85e-130

Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3; This subfamily is composed of the atypical yeast protein kinase Abc1p, its human homolog ADCK3 (also called CABC1), and similar proteins. Abc1p (also called Coq8p) is required for the biosynthesis of Coenzyme Q (ubiquinone or Q), which is an essential lipid component in respiratory electron and proton transport. It is necessary for the formation of a multi-subunit Q-biosynthetic complex and may also function in the regulation of Q synthesis. Human ADCK3 is able to rescue defects in Q synthesis and the phosphorylation state of Coq proteins in yeast Abc1 (or Coq8) mutants. Mutations in ADCK3 cause progressive cerebellar ataxia and atrophy due to Q10 deficiency. In algae and higher plants, ABC1 kinases have proliferated to more than 15 subfamilies, most of which are located in plastids or mitochondria. Subfamily 13 (ABC1K13) of plant ABC1 kinases belongs in this subfamily with yeast Abc1p and human ADCK3. ABC1 kinases are not related to the ATP-binding cassette (ABC) membrane transporter family.


:

Pssm-ID: 270872 [Multi-domain]  Cd Length: 251  Bit Score: 379.55  E-value: 3.85e-130
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22800617 175 IFERVRQSADFMPRWQMLRVLEEELGRDWQAKVASLEEVPFAAASIGQVHQGLLRDGTEVAVKIQYPGIAQSIQSDVQNL 254
Cdd:cd13970   2 ALARLRDSAPPMPWAQLEKVLEAELGEDWRELFAEFDEEPFAAASIGQVHRATLKDGREVAVKVQYPGVAESIDSDLNNL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22800617 255 LAVLKMSAALPAGLFAEQSLQALQQELAWECDYRREAACAQNFRQLLANDPFFRVPAVVKELCTTRVLGMELAGGVPLDQ 334
Cdd:cd13970  82 RRLLKLTGLLPKGLDLDALIAELREELLEECDYEREAANQRRFRELLADDPRFVVPEVIPELSTKRVLTTEFVDGVPLDE 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22800617 335 CQGLSQDLRNQICFQLLTLCLRELFEFRFMQTDPNWANFLYDASSHQVTLLDFGASREFGTEFTDHYIEVVKAAADGDRD 414
Cdd:cd13970 162 AADLSQEERNRIGELLLRLCLRELFEFGFMQTDPNPGNFLYDPEDGRLGLLDFGAVREYPPEFVDGYRRLVRAALEGDRE 241
                       250
                ....*....|
gi 22800617 415 CVLQKSRDLK 424
Cdd:cd13970 242 ALLEASVELG 251
 
Name Accession Description Interval E-value
ABC1_ADCK3 cd13970
Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3; This ...
175-424 3.85e-130

Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3; This subfamily is composed of the atypical yeast protein kinase Abc1p, its human homolog ADCK3 (also called CABC1), and similar proteins. Abc1p (also called Coq8p) is required for the biosynthesis of Coenzyme Q (ubiquinone or Q), which is an essential lipid component in respiratory electron and proton transport. It is necessary for the formation of a multi-subunit Q-biosynthetic complex and may also function in the regulation of Q synthesis. Human ADCK3 is able to rescue defects in Q synthesis and the phosphorylation state of Coq proteins in yeast Abc1 (or Coq8) mutants. Mutations in ADCK3 cause progressive cerebellar ataxia and atrophy due to Q10 deficiency. In algae and higher plants, ABC1 kinases have proliferated to more than 15 subfamilies, most of which are located in plastids or mitochondria. Subfamily 13 (ABC1K13) of plant ABC1 kinases belongs in this subfamily with yeast Abc1p and human ADCK3. ABC1 kinases are not related to the ATP-binding cassette (ABC) membrane transporter family.


Pssm-ID: 270872 [Multi-domain]  Cd Length: 251  Bit Score: 379.55  E-value: 3.85e-130
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22800617 175 IFERVRQSADFMPRWQMLRVLEEELGRDWQAKVASLEEVPFAAASIGQVHQGLLRDGTEVAVKIQYPGIAQSIQSDVQNL 254
Cdd:cd13970   2 ALARLRDSAPPMPWAQLEKVLEAELGEDWRELFAEFDEEPFAAASIGQVHRATLKDGREVAVKVQYPGVAESIDSDLNNL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22800617 255 LAVLKMSAALPAGLFAEQSLQALQQELAWECDYRREAACAQNFRQLLANDPFFRVPAVVKELCTTRVLGMELAGGVPLDQ 334
Cdd:cd13970  82 RRLLKLTGLLPKGLDLDALIAELREELLEECDYEREAANQRRFRELLADDPRFVVPEVIPELSTKRVLTTEFVDGVPLDE 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22800617 335 CQGLSQDLRNQICFQLLTLCLRELFEFRFMQTDPNWANFLYDASSHQVTLLDFGASREFGTEFTDHYIEVVKAAADGDRD 414
Cdd:cd13970 162 AADLSQEERNRIGELLLRLCLRELFEFGFMQTDPNPGNFLYDPEDGRLGLLDFGAVREYPPEFVDGYRRLVRAALEGDRE 241
                       250
                ....*....|
gi 22800617 415 CVLQKSRDLK 424
Cdd:cd13970 242 ALLEASVELG 251
ABC1 pfam03109
ABC1 atypical kinase-like domain; This family includes ABC1 from yeast and AarF from E. coli. ...
178-418 3.51e-81

ABC1 atypical kinase-like domain; This family includes ABC1 from yeast and AarF from E. coli. These proteins have a nuclear or mitochondrial subcellular location in eukaryotes. The exact molecular functions of these proteins is not clear, however yeast ABC1 suppresses a cytochrome b mRNA translation defect and is essential for the electron transfer in the bc 1 complex and E. coli AarF is required for ubiquinone production. It has been suggested that members of the ABC1 family are novel chaperonins. These proteins are unrelated to the ABC transporter proteins.


Pssm-ID: 427143 [Multi-domain]  Cd Length: 245  Bit Score: 253.70  E-value: 3.51e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22800617   178 RVRQSADFMPRWQMLRVLEEELGRDWQAKVASLEEVPFAAASIGQVHQGLLRDGTEVAVKIQYPGIAQSIQSDVQNLLAV 257
Cdd:pfam03109   1 KLQDRAPPFPFEQAKKVIEEELGAPVEEIFAEFDEEPIAAASIAQVHRARLKDGEEVAVKVQRPGVKKRIRSDLLLLRFL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22800617   258 LKMSAALPAGLFA-EQSLQALQQELAWECDYRREAACAQNFRQLLANDPFFRVPAVVKELCTTRVLGMELAGGVPLDQCQ 336
Cdd:pfam03109  81 AKVAKRFFPGFRRlDWLVDEFRKSLPQELDFLREAANAEKFRENFADDPDVYVPKVYWELTTERVLTMEYVDGIKIDDLD 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22800617   337 GLS--QDLRNQICFQLLTLCLRELFEFRFMQTDPNWANFLYDASShQVTLLDFGASREFGTEFTDHYIEVVKAAADGDRD 414
Cdd:pfam03109 161 ALSeaGIDRKEIARRLVELFLEQIFRDGFFHADPHPGNILVRKDG-RIVLLDFGLMGRLDEKFRRLYAELLLALVNRDYK 239

                  ....
gi 22800617   415 CVLQ 418
Cdd:pfam03109 240 RVAE 243
AarF COG0661
Predicted protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme ...
126-506 5.89e-77

Predicted protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]; Predicted protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440425 [Multi-domain]  Cd Length: 487  Bit Score: 250.89  E-value: 5.89e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22800617 126 SGLDSSPFLSEANAERIVQTLCTVRGAALKVGQMLSIQDNsFISPQLQHIFERVRQSADFMPRWQMLRVLEEELGRDWQA 205
Cdd:COG0661  39 TGEERREELRRRRAERLRLALEELGPTFIKLGQLLSTRPD-LLPPEYAEELAKLQDRVPPFPFEEVRAVIEEELGRPLEE 117
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22800617 206 KVASLEEVPFAAASIGQVHQGLLRDGTEVAVKIQYPGIAQSIQSDVQNLLAVLKMSAAL--------PAGLFAEQSlQAL 277
Cdd:COG0661 118 LFAEFDPEPLAAASIGQVHRARLKDGREVAVKVQRPGIEEAIEADLRILRRLARLLERLspegrrldPVEVVDEFA-RSL 196
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22800617 278 QQELawecDYRREAACAQNFRQLLANDPFFRVPAVVKELCTTRVLGMELAGGVPLDQCQGL--SQDLRNQICFQLLTLCL 355
Cdd:COG0661 197 LEEL----DYRREAANAERFRRNFADDPDVYVPKVYWELSTRRVLTMEWIDGIKISDLEALdaAGIDRKRLAERLVRAFL 272
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22800617 356 RELFEFRFMQTDPNWANFLYDAsSHQVTLLDFGASREFGTEFTDHYIEVVKAAADGDRDCVLQKSRDLKFLT-GFETKAF 434
Cdd:COG0661 273 RQVFRDGFFHADPHPGNIFVLP-DGRLVLLDFGMVGRLDPETREGLAELLLALLNRDYDRVAEALLELGFVPpDTDVDEL 351
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22800617 435 sdahVEAVMILGEPFATQGPYDFGSGETARRIQDLIpvlLRHRLCPPPEETYaLHRKLAGAFLACAHLRAHI 506
Cdd:COG0661 352 ----ERALRAVLEPYFGKPLKDISFGELLLELFELA---RRFPLRLPPELVL-LQRTLLTLEGVGRQLDPDF 415
ubiB PRK04750
putative ubiquinone biosynthesis protein UbiB; Reviewed
155-338 2.76e-18

putative ubiquinone biosynthesis protein UbiB; Reviewed


Pssm-ID: 235310 [Multi-domain]  Cd Length: 537  Bit Score: 88.04  E-value: 2.76e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22800617  155 KVGQMLSIQDNSF---ISPQLQHIFERVrqsADFMPRwQMLRVLEEELGRDWQAKVASLEEVPFAAASIGQVHQGLLRD- 230
Cdd:PRK04750  68 KFGQMLSTRRDLFppdIADELALLQDRV---PPFDGA-LARAIIEKALGGPVEEWFDDFDIKPLASASIAQVHFARLKDn 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22800617  231 GTEVAVKIQYPGIAQSIQSDvqnlLAVLKMSAALPAGLFAE-------QSLQALQQELAWECDYRREAACAQNFRQLLAN 303
Cdd:PRK04750 144 GREVVVKVLRPDILPVIDAD----LALMYRLARWVERLLPDgrrlkprEVVAEFEKTLHDELDLMREAANASQLRRNFED 219
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 22800617  304 DPFFRVPAVVKELCTTRVLGMELAGGVPLDQCQGL 338
Cdd:PRK04750 220 SDMLYVPEVYWDYCSETVMVMERMYGIPVSDVAAL 254
 
Name Accession Description Interval E-value
ABC1_ADCK3 cd13970
Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3; This ...
175-424 3.85e-130

Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3; This subfamily is composed of the atypical yeast protein kinase Abc1p, its human homolog ADCK3 (also called CABC1), and similar proteins. Abc1p (also called Coq8p) is required for the biosynthesis of Coenzyme Q (ubiquinone or Q), which is an essential lipid component in respiratory electron and proton transport. It is necessary for the formation of a multi-subunit Q-biosynthetic complex and may also function in the regulation of Q synthesis. Human ADCK3 is able to rescue defects in Q synthesis and the phosphorylation state of Coq proteins in yeast Abc1 (or Coq8) mutants. Mutations in ADCK3 cause progressive cerebellar ataxia and atrophy due to Q10 deficiency. In algae and higher plants, ABC1 kinases have proliferated to more than 15 subfamilies, most of which are located in plastids or mitochondria. Subfamily 13 (ABC1K13) of plant ABC1 kinases belongs in this subfamily with yeast Abc1p and human ADCK3. ABC1 kinases are not related to the ATP-binding cassette (ABC) membrane transporter family.


Pssm-ID: 270872 [Multi-domain]  Cd Length: 251  Bit Score: 379.55  E-value: 3.85e-130
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22800617 175 IFERVRQSADFMPRWQMLRVLEEELGRDWQAKVASLEEVPFAAASIGQVHQGLLRDGTEVAVKIQYPGIAQSIQSDVQNL 254
Cdd:cd13970   2 ALARLRDSAPPMPWAQLEKVLEAELGEDWRELFAEFDEEPFAAASIGQVHRATLKDGREVAVKVQYPGVAESIDSDLNNL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22800617 255 LAVLKMSAALPAGLFAEQSLQALQQELAWECDYRREAACAQNFRQLLANDPFFRVPAVVKELCTTRVLGMELAGGVPLDQ 334
Cdd:cd13970  82 RRLLKLTGLLPKGLDLDALIAELREELLEECDYEREAANQRRFRELLADDPRFVVPEVIPELSTKRVLTTEFVDGVPLDE 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22800617 335 CQGLSQDLRNQICFQLLTLCLRELFEFRFMQTDPNWANFLYDASSHQVTLLDFGASREFGTEFTDHYIEVVKAAADGDRD 414
Cdd:cd13970 162 AADLSQEERNRIGELLLRLCLRELFEFGFMQTDPNPGNFLYDPEDGRLGLLDFGAVREYPPEFVDGYRRLVRAALEGDRE 241
                       250
                ....*....|
gi 22800617 415 CVLQKSRDLK 424
Cdd:cd13970 242 ALLEASVELG 251
ABC1 pfam03109
ABC1 atypical kinase-like domain; This family includes ABC1 from yeast and AarF from E. coli. ...
178-418 3.51e-81

ABC1 atypical kinase-like domain; This family includes ABC1 from yeast and AarF from E. coli. These proteins have a nuclear or mitochondrial subcellular location in eukaryotes. The exact molecular functions of these proteins is not clear, however yeast ABC1 suppresses a cytochrome b mRNA translation defect and is essential for the electron transfer in the bc 1 complex and E. coli AarF is required for ubiquinone production. It has been suggested that members of the ABC1 family are novel chaperonins. These proteins are unrelated to the ABC transporter proteins.


Pssm-ID: 427143 [Multi-domain]  Cd Length: 245  Bit Score: 253.70  E-value: 3.51e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22800617   178 RVRQSADFMPRWQMLRVLEEELGRDWQAKVASLEEVPFAAASIGQVHQGLLRDGTEVAVKIQYPGIAQSIQSDVQNLLAV 257
Cdd:pfam03109   1 KLQDRAPPFPFEQAKKVIEEELGAPVEEIFAEFDEEPIAAASIAQVHRARLKDGEEVAVKVQRPGVKKRIRSDLLLLRFL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22800617   258 LKMSAALPAGLFA-EQSLQALQQELAWECDYRREAACAQNFRQLLANDPFFRVPAVVKELCTTRVLGMELAGGVPLDQCQ 336
Cdd:pfam03109  81 AKVAKRFFPGFRRlDWLVDEFRKSLPQELDFLREAANAEKFRENFADDPDVYVPKVYWELTTERVLTMEYVDGIKIDDLD 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22800617   337 GLS--QDLRNQICFQLLTLCLRELFEFRFMQTDPNWANFLYDASShQVTLLDFGASREFGTEFTDHYIEVVKAAADGDRD 414
Cdd:pfam03109 161 ALSeaGIDRKEIARRLVELFLEQIFRDGFFHADPHPGNILVRKDG-RIVLLDFGLMGRLDEKFRRLYAELLLALVNRDYK 239

                  ....
gi 22800617   415 CVLQ 418
Cdd:pfam03109 240 RVAE 243
AarF COG0661
Predicted protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme ...
126-506 5.89e-77

Predicted protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]; Predicted protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440425 [Multi-domain]  Cd Length: 487  Bit Score: 250.89  E-value: 5.89e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22800617 126 SGLDSSPFLSEANAERIVQTLCTVRGAALKVGQMLSIQDNsFISPQLQHIFERVRQSADFMPRWQMLRVLEEELGRDWQA 205
Cdd:COG0661  39 TGEERREELRRRRAERLRLALEELGPTFIKLGQLLSTRPD-LLPPEYAEELAKLQDRVPPFPFEEVRAVIEEELGRPLEE 117
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22800617 206 KVASLEEVPFAAASIGQVHQGLLRDGTEVAVKIQYPGIAQSIQSDVQNLLAVLKMSAAL--------PAGLFAEQSlQAL 277
Cdd:COG0661 118 LFAEFDPEPLAAASIGQVHRARLKDGREVAVKVQRPGIEEAIEADLRILRRLARLLERLspegrrldPVEVVDEFA-RSL 196
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22800617 278 QQELawecDYRREAACAQNFRQLLANDPFFRVPAVVKELCTTRVLGMELAGGVPLDQCQGL--SQDLRNQICFQLLTLCL 355
Cdd:COG0661 197 LEEL----DYRREAANAERFRRNFADDPDVYVPKVYWELSTRRVLTMEWIDGIKISDLEALdaAGIDRKRLAERLVRAFL 272
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22800617 356 RELFEFRFMQTDPNWANFLYDAsSHQVTLLDFGASREFGTEFTDHYIEVVKAAADGDRDCVLQKSRDLKFLT-GFETKAF 434
Cdd:COG0661 273 RQVFRDGFFHADPHPGNIFVLP-DGRLVLLDFGMVGRLDPETREGLAELLLALLNRDYDRVAEALLELGFVPpDTDVDEL 351
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22800617 435 sdahVEAVMILGEPFATQGPYDFGSGETARRIQDLIpvlLRHRLCPPPEETYaLHRKLAGAFLACAHLRAHI 506
Cdd:COG0661 352 ----ERALRAVLEPYFGKPLKDISFGELLLELFELA---RRFPLRLPPELVL-LQRTLLTLEGVGRQLDPDF 415
ABC1_ADCK3-like cd05121
Activator of bc1 complex (ABC1) kinases (also called aarF domain containing kinase 3) and ...
186-414 7.47e-60

Activator of bc1 complex (ABC1) kinases (also called aarF domain containing kinase 3) and similar proteins; This family is composed of the atypical yeast protein kinase Abc1p, its human homolog ADCK3 (also called CABC1), and similar proteins. Abc1p (also called Coq8p) is required for the biosynthesis of Coenzyme Q (ubiquinone or Q), which is an essential lipid component in respiratory electron and proton transport. It is necessary for the formation of a multi-subunit Q-biosynthetic complex and may also function in the regulation of Q synthesis. Human ADCK3 is able to rescue defects in Q synthesis and the phosphorylation state of Coq proteins in yeast Abc1 (or Coq8) mutants. Mutations in ADCK3 cause progressive cerebellar ataxia and atrophy due to Q10 deficiency. Eukaryotes contain at least two more ABC1/ADCK3-like proteins: in humans, these are the putative atypical protein kinases named ADCK1 and ADCK2. In algae and higher plants, ABC1 kinases have proliferated to more than 15 subfamilies, most of which are located in plastids or mitochondria. Eight of these plant ABC1 kinase subfamilies (ABC1K1-8) are specific for photosynthetic organisms. ABC1 kinases are not related to the ATP-binding cassette (ABC) membrane transporter family.


Pssm-ID: 270691 [Multi-domain]  Cd Length: 247  Bit Score: 198.49  E-value: 7.47e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22800617 186 MPRWQMLRVLEEELGRDWQAKVASLEEVPFAAASIGQVHQGLLRDGTEVAVKIQYPGIAQSIQSDVQNLLAVLKMSAALP 265
Cdd:cd05121   9 FPFEEVRKIIEEELGRPLEEVFAEFDPEPLAAASIAQVHRARLKDGREVAVKVQRPGIEEIIEADLRILRRLARLLERLS 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22800617 266 aGLFAEQSLQALQQELAW----ECDYRREAACAQNFRQLLANDPFFRVPAVVKELCTTRVLGMELAGGVPLDQCQGLSQD 341
Cdd:cd05121  89 -PLLRRLDLVAIVDEFARslleELDFRREARNAERFRKNLKDSPDVYVPKVYPELSTRRVLVMEYIDGVKLTDLEALRAA 167
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 22800617 342 L--RNQICFQLLTLCLRELFEFRFMQTDPNWANFLYDAsSHQVTLLDFGASREFGTEFTDHYIEVVKAAADGDRD 414
Cdd:cd05121 168 GidRKELARRLVDAYLKQIFEDGFFHADPHPGNILVLP-DGRIALLDFGMVGRLDPETREALADLLLALVNGDAE 241
ADCK1-like cd13969
aarF domain containing kinase 1 and similar proteins; This subfamily is composed of ...
193-423 5.68e-39

aarF domain containing kinase 1 and similar proteins; This subfamily is composed of uncharacterized ABC1 kinase-like proteins including the human protein called aarF domain containing kinase 1 (ADCK1). Eukaryotes contain at least three ABC1-like proteins: in humans, these are ADCK3 and the putative protein kinases named ADCK1 and ADCK2. Yeast Abc1p and its human homolog ADCK3 are atypical protein kinases required for the biosynthesis of Coenzyme Q (ubiquinone or Q), which is an essential lipid component in respiratory electron and proton transport. In algae and higher plants, ABC1 kinases have proliferated to more than 15 subfamilies, most of which are located in plastids or mitochondria. Plant subfamilies 14 and 15 (ABC1K14-15) belong to the same group of ABC1 kinases as human ADCK1. ABC1 kinases are not related to the ATP-binding cassette (ABC) membrane transporter family.


Pssm-ID: 270871 [Multi-domain]  Cd Length: 253  Bit Score: 143.01  E-value: 5.68e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22800617 193 RVLEEELGRDWQAKVASLEEVPFAAASIGQVHQGLLRDGTEVAVKIQYPGIAQSIQSDVQNLLAVLKMSAAL----PAGL 268
Cdd:cd13969  16 RVFKEDLGKPPEELFSEFDEEPIASASLAQVHKAKLKDGEEVAVKVQHPDLRKQFAGDLATMEFLVNLVEKLfpdfPFSW 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22800617 269 FAEQSLQALQQELawecDYRREAACAQNFRQLLANDPFFRVPAVVKELCTTRVLGMELAGGVPLDQCQGL-SQDL-RNQI 346
Cdd:cd13969  96 LVDELKKNLPKEL----DFLNEARNAERCAKLFKHRPDVYVPKVYWDLSSKRVLTMEFIDGIKIDDVEALkKLGIdPKEV 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22800617 347 CFQLLTLCLRELFEFRFMQTDPNWANFL----YDASSHQVTLLDFGASREFGTEFTDHYIEVVKAAADGDRDCVLQKSRD 422
Cdd:cd13969 172 ARLLSEAFAEMIFVHGFVHCDPHPGNLLvrknPGPGKPQIVLLDHGLYRELDEEFRLNYCRLWKALILGDEKKIKKYSKA 251

                .
gi 22800617 423 L 423
Cdd:cd13969 252 L 252
UbiB cd13972
Ubiquinone biosynthetic protein UbiB; UbiB is the prokaryotic homolog of yeast Abc1p and human ...
193-388 1.20e-29

Ubiquinone biosynthetic protein UbiB; UbiB is the prokaryotic homolog of yeast Abc1p and human ADCK3 (aarF domain containing kinase 3). It is required for the biosynthesis of Coenzyme Q (ubiquinone or Q), which is an essential lipid component in respiratory electron and proton transport. It is required in the first monooxygenase step in Q biosynthesis. Mutant strains with disrupted ubiB genes lack Q and accumulate octaprenylphenol, a Q biosynthetic intermediate.


Pssm-ID: 270874 [Multi-domain]  Cd Length: 247  Bit Score: 116.92  E-value: 1.20e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22800617 193 RVLEEELGRDWQAKVASLEEVPFAAASIGQVHQGLLRDGTEVAVKIQYPGIAQSIQSDvqnlLAVLKMSAALPAGLFAE- 271
Cdd:cd13972  16 AIIEAELGKPLDALFSDFDEEPVAAASIAQVHKARLLDGREVAVKVLRPGIEKRIERD----LELLRFLARLAERLLPEa 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22800617 272 ------QSLQALQQELAWECDYRREAACAQNFRQLLANDPFFRVPAVVKELCTTRVLGMELAGGVPLDQCQGLSQ---Dl 342
Cdd:cd13972  92 rrlrpvEVVKEFARSLLLELDLRLEAANASELRENFLDDPGFYVPEVYWELTSKNVLTMEWIDGIPISDIEALDAagiD- 170
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 22800617 343 RNQICFQLLTLCLRELFEFRFMQTDPNWANFLYDAsSHQVTLLDFG 388
Cdd:cd13972 171 RKALAERLVEIFFRQVFRDGFFHADMHPGNIFVDP-NGRIIAVDFG 215
ubiB PRK04750
putative ubiquinone biosynthesis protein UbiB; Reviewed
155-338 2.76e-18

putative ubiquinone biosynthesis protein UbiB; Reviewed


Pssm-ID: 235310 [Multi-domain]  Cd Length: 537  Bit Score: 88.04  E-value: 2.76e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22800617  155 KVGQMLSIQDNSF---ISPQLQHIFERVrqsADFMPRwQMLRVLEEELGRDWQAKVASLEEVPFAAASIGQVHQGLLRD- 230
Cdd:PRK04750  68 KFGQMLSTRRDLFppdIADELALLQDRV---PPFDGA-LARAIIEKALGGPVEEWFDDFDIKPLASASIAQVHFARLKDn 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22800617  231 GTEVAVKIQYPGIAQSIQSDvqnlLAVLKMSAALPAGLFAE-------QSLQALQQELAWECDYRREAACAQNFRQLLAN 303
Cdd:PRK04750 144 GREVVVKVLRPDILPVIDAD----LALMYRLARWVERLLPDgrrlkprEVVAEFEKTLHDELDLMREAANASQLRRNFED 219
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 22800617  304 DPFFRVPAVVKELCTTRVLGMELAGGVPLDQCQGL 338
Cdd:PRK04750 220 SDMLYVPEVYWDYCSETVMVMERMYGIPVSDVAAL 254
ADCK2-like cd13971
aarF domain containing kinase 2 and similar proteins; This subfamily is composed of ...
190-422 6.95e-18

aarF domain containing kinase 2 and similar proteins; This subfamily is composed of uncharacterized ABC1 kinase-like proteins including the human protein called aarF domain containing kinase 2 (ADCK2). Eukaryotes contain at least three ABC1-like proteins; in humans, these are ADCK3 and the putative protein kinases named ADCK1 and ADCK2. Yeast Abc1p and its human homolog ADCK3 are atypical protein kinases required for the biosynthesis of Coenzyme Q (ubiquinone or Q), which is an essential lipid component in respiratory electron and proton transport. In algae and higher plants, ABC1 kinases have proliferated to more than 15 subfamilies, most of which are located in plastids or mitochondria. Plant subfamily 10 (ABC1K10) belong to the same group of ABC1 kinases as human ADCK2. ABC1 kinases are not related to the ATP-binding cassette (ABC) membrane transporter family.


Pssm-ID: 270873 [Multi-domain]  Cd Length: 298  Bit Score: 84.20  E-value: 6.95e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22800617 190 QMLRVLEEELGRDWQAKVASLEEVPFAAASIGQVHQGLLRD--------GTEVAVKIQYPGIAQSIQSDVQNLLAVLKMS 261
Cdd:cd13971  13 HTERALEAAFGKDWEDIFEEFDEEPIGSGSIAQVHRAKLKPdyggdgggPRVVAVKVLHPGVREQIERDLAILRLFAKLL 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22800617 262 AALPAG--LFAEQSLQALQQELAWECDYRREAACAQNFRQLLANDPFFRVPAVVKELCTTRVLGMELAGGVPL--DQCQG 337
Cdd:cd13971  93 EAIPPLrwLSLPESVEQFASLMLRQLDLRVEAANLERFRENFKDRKDVSFPKPLYPLVTEEVLVETFEEGVPIsrTVLAH 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22800617 338 LSQDLRNQICFQLLTLCLRELFEFRFM-----------QTDPNWANFLYDASSH-----QVTLLDFGASREFGTEFTDHY 401
Cdd:cd13971 173 GGEPLKRKLARIGLDAFLKMLFVDNFVhgdlhpgnilvRFNDSNRPSLLVSLDArgsppRLVFLDAGLVTELSPQDRRNF 252
                       250       260
                ....*....|....*....|....*
gi 22800617 402 IEVVKAAA--DGDR--DCVLQKSRD 422
Cdd:cd13971 253 IDLFKAVArgDGYKaaELMLERSRS 277
PKc_like cd13968
Catalytic domain of the Protein Kinase superfamily; The PK superfamily contains the large ...
286-388 7.46e-12

Catalytic domain of the Protein Kinase superfamily; The PK superfamily contains the large family of typical PKs that includes serine/threonine kinases (STKs), protein tyrosine kinases (PTKs), and dual-specificity PKs that phosphorylate both serine/threonine and tyrosine residues of target proteins, as well as pseudokinases that lack crucial residues for catalytic activity and/or ATP binding. It also includes phosphoinositide 3-kinases (PI3Ks), aminoglycoside 3'-phosphotransferases (APHs), choline kinase (ChoK), Actin-Fragmin Kinase (AFK), and the atypical RIO and Abc1p-like protein kinases. These proteins catalyze the transfer of the gamma-phosphoryl group from ATP to their target substrates; these include serine/threonine/tyrosine residues in proteins for typical or atypical PKs, the 3-hydroxyl of the inositol ring of D-myo-phosphatidylinositol (PtdIns) or its derivatives for PI3Ks, the 4-hydroxyl of PtdIns for PI4Ks, and other small molecule substrates for APH/ChoK and similar proteins such as aminoglycosides, macrolides, choline, ethanolamine, and homoserine.


Pssm-ID: 270870 [Multi-domain]  Cd Length: 136  Bit Score: 62.84  E-value: 7.46e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22800617 286 DYRREAACAQNFRQLLANDPFFRVPAVVKelcTTRVLGMELAGGVPLDQ--CQGLSQDLRNQICFQLLTLCLRELFEFRF 363
Cdd:cd13968  36 DLESEMDILRRLKGLELNIPKVLVTEDVD---GPNILLMELVKGGTLIAytQEEELDEKDVESIMYQLAECMRLLHSFHL 112
                        90       100
                ....*....|....*....|....*
gi 22800617 364 MQTDPNWANFLYDaSSHQVTLLDFG 388
Cdd:cd13968 113 IHRDLNNDNILLS-EDGNVKLIDFG 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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