NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|15277891|gb|AAH12938|]
View 

TBL2 protein [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
76-398 1.02e-43

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 158.15  E-value: 1.02e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15277891  76 NFTHRLLAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDflQREHRSMRAnveldHATLVR---FSPDCRaFI 152
Cdd:COG2319 106 DLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT--GKLLRTLTG-----HSGAVTsvaFSPDGK-LL 177

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15277891 153 VWLANGDTLRVFKMTKREDgGYTFTAtpedfpkkHKAPVIDIGIANTGKFIMTASSDTTVLIWSLK-GQVLSTINTNQMN 231
Cdd:COG2319 178 ASGSDDGTVRLWDLATGKL-LRTLTG--------HTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGHSGS 248

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15277891 232 NTHAAVSPCGRFVASCGFTPDVKVWEVcfgKKGEfqevvRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDve 311
Cdd:COG2319 249 VRSVAFSPDGRLLASGSADGTVRLWDL---ATGE-----LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-- 318

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15277891 312 ykkkqDPYLLKTGRfeeAAGAAPCRLALSPNAQVLALASG-SSIHLYNTRRGEKEECFeRVHGECIANLSFDITGRFLAS 390
Cdd:COG2319 319 -----TGKLLRTLT---GHTGAVRSVAFSPDGKTLASGSDdGTVRLWDLATGELLRTL-TGHTGAVTSVAFSPDGRTLAS 389


                ....*....
gi 15277891 391 CG-DRAVRL 398
Cdd:COG2319 390 GSaDGTVRL 398
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
76-398 1.02e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 158.15  E-value: 1.02e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15277891  76 NFTHRLLAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDflQREHRSMRAnveldHATLVR---FSPDCRaFI 152
Cdd:COG2319 106 DLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT--GKLLRTLTG-----HSGAVTsvaFSPDGK-LL 177

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15277891 153 VWLANGDTLRVFKMTKREDgGYTFTAtpedfpkkHKAPVIDIGIANTGKFIMTASSDTTVLIWSLK-GQVLSTINTNQMN 231
Cdd:COG2319 178 ASGSDDGTVRLWDLATGKL-LRTLTG--------HTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGHSGS 248

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15277891 232 NTHAAVSPCGRFVASCGFTPDVKVWEVcfgKKGEfqevvRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDve 311
Cdd:COG2319 249 VRSVAFSPDGRLLASGSADGTVRLWDL---ATGE-----LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-- 318

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15277891 312 ykkkqDPYLLKTGRfeeAAGAAPCRLALSPNAQVLALASG-SSIHLYNTRRGEKEECFeRVHGECIANLSFDITGRFLAS 390
Cdd:COG2319 319 -----TGKLLRTLT---GHTGAVRSVAFSPDGKTLASGSDdGTVRLWDLATGELLRTL-TGHTGAVTSVAFSPDGRTLAS 389


                ....*....
gi 15277891 391 CG-DRAVRL 398
Cdd:COG2319 390 GSaDGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 82-399 1.54e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 130.15  E-value: 1.54e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15277891  82 LAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQrehrsMRANVELDHA-TLVRFSPDcRAFIVWLANGDT 160
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGEL-----LRTLKGHTGPvRDVAASAD-GTYLASGSSDKT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15277891 161 LRVFKMTKREDgGYTFTAtpedfpkkHKAPVIDIGIANTGKFIMTASSDTTVLIWSL-KGQVLSTINTNQMNNTHAAVSP 239
Cdd:cd00200  75 IRLWDLETGEC-VRTLTG--------HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVeTGKCLTTLRGHTDWVNSVAFSP 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15277891 240 CGRFVASCGFTPDVKVWEVcfgKKGEFQEVvrafeLKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDveyKKKQdpy 319
Cdd:cd00200 146 DGTFVASSSQDGTIKLWDL---RTGKCVAT-----LTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS---TGKC--- 211

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15277891 320 lLKTGRFEEaagAAPCRLALSPNAQVLALASG-SSIHLYNTRRGEKEECFERVHGECIAnLSFDITGRFLASCG-DRAVR 397
Cdd:cd00200 212 -LGTLRGHE---NGVNSVAFSPDGYLLASGSEdGTIRVWDLRTGECVQTLSGHTNSVTS-LAWSPDGKRLASGSaDGTIR 286


                ..
gi 15277891 398 LF 399
Cdd:cd00200 287 IW 288
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 86-118 2.06e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.70  E-value: 2.06e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 15277891     86 LKSHSGNISCMDFSSNGKYLATCADDRTIRIWS 118
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
86-118 6.01e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.58  E-value: 6.01e-09
                          10        20        30
                  ....*....|....*....|....*....|...
gi 15277891    86 LKSHSGNISCMDFSSNGKYLATCADDRTIRIWS 118
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
76-398 1.02e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 158.15  E-value: 1.02e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15277891  76 NFTHRLLAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDflQREHRSMRAnveldHATLVR---FSPDCRaFI 152
Cdd:COG2319 106 DLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT--GKLLRTLTG-----HSGAVTsvaFSPDGK-LL 177

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15277891 153 VWLANGDTLRVFKMTKREDgGYTFTAtpedfpkkHKAPVIDIGIANTGKFIMTASSDTTVLIWSLK-GQVLSTINTNQMN 231
Cdd:COG2319 178 ASGSDDGTVRLWDLATGKL-LRTLTG--------HTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGHSGS 248

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15277891 232 NTHAAVSPCGRFVASCGFTPDVKVWEVcfgKKGEfqevvRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDve 311
Cdd:COG2319 249 VRSVAFSPDGRLLASGSADGTVRLWDL---ATGE-----LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-- 318

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15277891 312 ykkkqDPYLLKTGRfeeAAGAAPCRLALSPNAQVLALASG-SSIHLYNTRRGEKEECFeRVHGECIANLSFDITGRFLAS 390
Cdd:COG2319 319 -----TGKLLRTLT---GHTGAVRSVAFSPDGKTLASGSDdGTVRLWDLATGELLRTL-TGHTGAVTSVAFSPDGRTLAS 389


                ....*....
gi 15277891 391 CG-DRAVRL 398
Cdd:COG2319 390 GSaDGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
80-415 5.59e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 142.36  E-value: 5.59e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15277891  80 RLLAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWStkdfLQREHRSMRANVELDHATLVRFSPDCRaFIVWLANGD 159
Cdd:COG2319  68 GALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWD----LATGLLLRTLTGHTGAVRSVAFSPDGK-TLASGSADG 142

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15277891 160 TLRVFKMTKREDgGYTFTAtpedfpkkHKAPVIDIGIANTGKFIMTASSDTTVLIWSLK-GQVLSTINTNQMNNTHAAVS 238
Cdd:COG2319 143 TVRLWDLATGKL-LRTLTG--------HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAVRSVAFS 213

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15277891 239 PCGRFVASCGFTPDVKVWEVcfgKKGEFQevvraFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDveykkkqdp 318
Cdd:COG2319 214 PDGKLLASGSADGTVRLWDL---ATGKLL-----RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA--------- 276

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15277891 319 yllkTG---RFEEAAGAAPCRLALSPNAQVLALASG-SSIHLYNTRRGEKEECFERvHGECIANLSFDITGRFLASCG-D 393
Cdd:COG2319 277 ----TGellRTLTGHSGGVNSVAFSPDGKLLASGSDdGTVRLWDLATGKLLRTLTG-HTGAVRSVAFSPDGKTLASGSdD 351

                       330       340
                ....*....|....*....|..
gi 15277891 394 RAVRLFHNTPGHRamVEEMQGH 415
Cdd:COG2319 352 GTVRLWDLATGEL--LRTLTGH 371
WD40 COG2319
WD40 repeat [General function prediction only];
82-309 1.32e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.81  E-value: 1.32e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15277891  82 LAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDflQREHRSMRANVELDHAtlVRFSPDCRafivWLANGD-- 159
Cdd:COG2319 196 LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT--GKLLRTLTGHSGSVRS--VAFSPDGR----LLASGSad 267

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15277891 160 -TLRVFKMTkredggytfTATPEDFPKKHKAPVIDIGIANTGKFIMTASSDTTVLIWSLK-GQVLSTINTNQMNNTHAAV 237
Cdd:COG2319 268 gTVRLWDLA---------TGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAVRSVAF 338

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15277891 238 SPCGRFVASCGFTPDVKVWEVCFGKKGEfqevvrafELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTD 309
Cdd:COG2319 339 SPDGKTLASGSDDGTVRLWDLATGELLR--------TLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 82-399 1.54e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 130.15  E-value: 1.54e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15277891  82 LAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQrehrsMRANVELDHA-TLVRFSPDcRAFIVWLANGDT 160
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGEL-----LRTLKGHTGPvRDVAASAD-GTYLASGSSDKT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15277891 161 LRVFKMTKREDgGYTFTAtpedfpkkHKAPVIDIGIANTGKFIMTASSDTTVLIWSL-KGQVLSTINTNQMNNTHAAVSP 239
Cdd:cd00200  75 IRLWDLETGEC-VRTLTG--------HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVeTGKCLTTLRGHTDWVNSVAFSP 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15277891 240 CGRFVASCGFTPDVKVWEVcfgKKGEFQEVvrafeLKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDveyKKKQdpy 319
Cdd:cd00200 146 DGTFVASSSQDGTIKLWDL---RTGKCVAT-----LTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS---TGKC--- 211

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15277891 320 lLKTGRFEEaagAAPCRLALSPNAQVLALASG-SSIHLYNTRRGEKEECFERVHGECIAnLSFDITGRFLASCG-DRAVR 397
Cdd:cd00200 212 -LGTLRGHE---NGVNSVAFSPDGYLLASGSEdGTIRVWDLRTGECVQTLSGHTNSVTS-LAWSPDGKRLASGSaDGTIR 286


                ..
gi 15277891 398 LF 399
Cdd:cd00200 287 IW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 76-358 3.99e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 112.81  E-value: 3.99e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15277891  76 NFTHRLLAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDflQREHRSMRAnveldHATLVR---FSPDCRafI 152
Cdd:cd00200  37 DLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET--GECVRTLTG-----HTSYVSsvaFSPDGR--I 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15277891 153 VWLANGD-TLRVFKMTKREDgGYTFTAtpedfpkkHKAPVIDIGIANTGKFIMTASSDTTVLIWSLK-GQVLSTINTNQM 230
Cdd:cd00200 108 LSSSSRDkTIKVWDVETGKC-LTTLRG--------HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRtGKCVATLTGHTG 178

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15277891 231 NNTHAAVSPCGRFVASCGFTPDVKVWEVCFGKKGEfqevvrafELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDV 310
Cdd:cd00200 179 EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLG--------TLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRT 250

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 15277891 311 EYKKKQdpyllktgrFEEAAGAAPCrLALSPNAQVlaLASGS---SIHLYN 358
Cdd:cd00200 251 GECVQT---------LSGHTNSVTS-LAWSPDGKR--LASGSadgTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
187-409 7.80e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.04  E-value: 7.80e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15277891 187 HKAPVIDIGIANTGKFIMTASSDTTVLIW-SLKGQVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVCFGKkge 265
Cdd:COG2319  35 LAAAVASLAASPDGARLAAGAGDLTLLLLdAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGL--- 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15277891 266 fqevvRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDtdveykkkqdpylLKTGR----FEEAAGAAPCrLALSP 341
Cdd:COG2319 112 -----LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD-------------LATGKllrtLTGHSGAVTS-VAFSP 172

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15277891 342 NAQVLALASG-SSIHLYNTRRGEKEECFeRVHGECIANLSFDITGRFLASCG-DRAVRLF--------HNTPGHRAMV 409
Cdd:COG2319 173 DGKLLASGSDdGTVRLWDLATGKLLRTL-TGHTGAVRSVAFSPDGKLLASGSaDGTVRLWdlatgkllRTLTGHSGSV 249
WD40 COG2319
WD40 repeat [General function prediction only];
76-219 5.53e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.49  E-value: 5.53e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15277891  76 NFTHRLLAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDflQREHRSMRANVelDHATLVRFSPDCRaFIVWL 155
Cdd:COG2319 274 DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAT--GKLLRTLTGHT--GAVRSVAFSPDGK-TLASG 348

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15277891 156 ANGDTLRVFKMTKREDGgYTFTAtpedfpkkHKAPVIDIGIANTGKFIMTASSDTTVLIWSLKG 219
Cdd:COG2319 349 SDDGTVRLWDLATGELL-RTLTG--------HTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
206-415 4.86e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.24  E-value: 4.86e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15277891 206 ASSDTTVLIWSLKGQVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVcfgkkgefQEVVRAFELKGHSAAVHSF 285
Cdd:COG2319  13 SADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDA--------AAGALLATLLGHTAAVLSV 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15277891 286 AFSNDSRRMASVSKDGTWKLWDTDveykkkqDPYLLKTGRFEEAAGAApcrLALSPNAQVLALASG-SSIHLYNTRRGEK 364
Cdd:COG2319  85 AFSPDGRLLASASADGTVRLWDLA-------TGLLLRTLTGHTGAVRS---VAFSPDGKTLASGSAdGTVRLWDLATGKL 154

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 15277891 365 EECFERvHGECIANLSFDITGRFLASCG-DRAVRLFHNTPGHRamVEEMQGH 415
Cdd:COG2319 155 LRTLTG-HSGAVTSVAFSPDGKLLASGSdDGTVRLWDLATGKL--LRTLTGH 203
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 86-118 2.06e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.70  E-value: 2.06e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 15277891     86 LKSHSGNISCMDFSSNGKYLATCADDRTIRIWS 118
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
86-118 6.01e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.58  E-value: 6.01e-09
                          10        20        30
                  ....*....|....*....|....*....|...
gi 15277891    86 LKSHSGNISCMDFSSNGKYLATCADDRTIRIWS 118
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 273-307 2.22e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.00  E-value: 2.22e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 15277891    273 FELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWD 307
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
274-307 6.06e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 6.06e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 15277891   274 ELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWD 307
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 185-216 8.01e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.21  E-value: 8.01e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 15277891    185 KKHKAPVIDIGIANTGKFIMTASSDTTVLIWS 216
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH