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Conserved domains on  [gi|16307459|gb|AAH10277|]
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Expressed sequence AI449175 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 15-51 7.44e-17

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 73.66  E-value: 7.44e-17
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 16307459    15 LVSFEDLVVHFTQDEWDLLAPSQKTLYGDVMLETFRN 51
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRN 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
147-398 9.56e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.01  E-value: 9.56e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16307459 147 GSQPVRKSYECNQCGKTLSSYNSLQRHQKIHIEErPYKCQQCTKAFRCLNALQ------SHERIHTGEKPYECKHCGTAF 220
Cdd:COG5048 192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPKSLLSQspsslsSSDSSSSASESPRSSLPTASS 270

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16307459 221 SRLTHLRLHEKVHTG-EKHYECKQCNIVFKSQSSYHRHK------IMHGETFYNCKE-CGKSFIYPSLLQMHERTHTGEK 292
Cdd:COG5048 271 QSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsvnhsGESLKPFSCPYSlCGKLFSRNDALKRHILLHTSIS 350

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16307459 293 PYECKLC-------GKTFRYHSSIRLHERTHTGEKPYECKH--CGKAFTRQSYLQFHERSHTGEKPYECK--ECGKAFRH 361
Cdd:COG5048 351 PAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNR 430

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 16307459 362 HSYLRLHERRHTGEKPYQCGQCGRSFSRQSSFKRHQS 398
Cdd:COG5048 431 HYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 15-51 7.44e-17

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 73.66  E-value: 7.44e-17
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 16307459    15 LVSFEDLVVHFTQDEWDLLAPSQKTLYGDVMLETFRN 51
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRN 37
KRAB smart00349
krueppel associated box;
16-58 5.65e-16

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 71.85  E-value: 5.65e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 16307459     16 VSFEDLVVHFTQDEWDLLAPSQKTLYGDVMLETFRNFTDTGCE 58
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 16-51 8.27e-13

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 62.18  E-value: 8.27e-13
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 16307459  16 VSFEDLVVHFTQDEWDLLAPSQKTLYGDVMLETFRN 51
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYEN 36
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
147-398 9.56e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.01  E-value: 9.56e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16307459 147 GSQPVRKSYECNQCGKTLSSYNSLQRHQKIHIEErPYKCQQCTKAFRCLNALQ------SHERIHTGEKPYECKHCGTAF 220
Cdd:COG5048 192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPKSLLSQspsslsSSDSSSSASESPRSSLPTASS 270

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16307459 221 SRLTHLRLHEKVHTG-EKHYECKQCNIVFKSQSSYHRHK------IMHGETFYNCKE-CGKSFIYPSLLQMHERTHTGEK 292
Cdd:COG5048 271 QSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsvnhsGESLKPFSCPYSlCGKLFSRNDALKRHILLHTSIS 350

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16307459 293 PYECKLC-------GKTFRYHSSIRLHERTHTGEKPYECKH--CGKAFTRQSYLQFHERSHTGEKPYECK--ECGKAFRH 361
Cdd:COG5048 351 PAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNR 430

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 16307459 362 HSYLRLHERRHTGEKPYQCGQCGRSFSRQSSFKRHQS 398
Cdd:COG5048 431 HYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
336-361 3.17e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.17e-04
                          10        20
                  ....*....|....*....|....*.
gi 16307459   336 YLQFHERSHTGEKPYECKECGKAFRH 361
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 15-51 7.44e-17

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 73.66  E-value: 7.44e-17
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 16307459    15 LVSFEDLVVHFTQDEWDLLAPSQKTLYGDVMLETFRN 51
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRN 37
KRAB smart00349
krueppel associated box;
16-58 5.65e-16

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 71.85  E-value: 5.65e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 16307459     16 VSFEDLVVHFTQDEWDLLAPSQKTLYGDVMLETFRNFTDTGCE 58
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 16-51 8.27e-13

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 62.18  E-value: 8.27e-13
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 16307459  16 VSFEDLVVHFTQDEWDLLAPSQKTLYGDVMLETFRN 51
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYEN 36
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
147-398 9.56e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.01  E-value: 9.56e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16307459 147 GSQPVRKSYECNQCGKTLSSYNSLQRHQKIHIEErPYKCQQCTKAFRCLNALQ------SHERIHTGEKPYECKHCGTAF 220
Cdd:COG5048 192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPKSLLSQspsslsSSDSSSSASESPRSSLPTASS 270

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16307459 221 SRLTHLRLHEKVHTG-EKHYECKQCNIVFKSQSSYHRHK------IMHGETFYNCKE-CGKSFIYPSLLQMHERTHTGEK 292
Cdd:COG5048 271 QSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsvnhsGESLKPFSCPYSlCGKLFSRNDALKRHILLHTSIS 350

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16307459 293 PYECKLC-------GKTFRYHSSIRLHERTHTGEKPYECKH--CGKAFTRQSYLQFHERSHTGEKPYECK--ECGKAFRH 361
Cdd:COG5048 351 PAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNR 430

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 16307459 362 HSYLRLHERRHTGEKPYQCGQCGRSFSRQSSFKRHQS 398
Cdd:COG5048 431 HYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
336-361 3.17e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.17e-04
                          10        20
                  ....*....|....*....|....*.
gi 16307459   336 YLQFHERSHTGEKPYECKECGKAFRH 361
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
281-305 4.01e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.01e-04
                          10        20
                  ....*....|....*....|....*
gi 16307459   281 LQMHERTHTGEKPYECKLCGKTFRY 305
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
310-333 1.07e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.07e-03
                          10        20
                  ....*....|....*....|....
gi 16307459   310 RLHERTHTGEKPYECKHCGKAFTR 333
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
163-289 1.38e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 1.38e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16307459 163 TLSSYNSLQRHQKIHIEERPYKCQQCTKAFRCLNALQSHERIHTGEKPYECKHCGTAFSRLTHL---RLHEKVHTGEKHY 239
Cdd:COG5048  14 SVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLelsRHLRTHHNNPSDL 93

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 16307459 240 ECKQCNIVFKSQSSY-HRHKIMHGETFYNCKECGKSFIYPSLLQMHERTHT 289
Cdd:COG5048  94 NSKSLPLSNSKASSSsLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSIS 144
zf-H2C2_2 pfam13465
Zinc-finger double domain;
364-389 1.54e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.54e-03
                          10        20
                  ....*....|....*....|....*.
gi 16307459   364 YLRLHERRHTGEKPYQCGQCGRSFSR 389
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
169-194 2.91e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.91e-03
                          10        20
                  ....*....|....*....|....*.
gi 16307459   169 SLQRHQKIHIEERPYKCQQCTKAFRC 194
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
197-222 3.34e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.34e-03
                          10        20
                  ....*....|....*....|....*.
gi 16307459   197 ALQSHERIHTGEKPYECKHCGTAFSR 222
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 318-373 4.85e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.93  E-value: 4.85e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16307459 318 GEKPYECK--HCGKAFTRQSYLQFH---------------ERSHTG----EKPYECKECGKAFRHHSYLRLHeRRHT 373
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHmlhghqnqklhenpsPEKMNIfsakDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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