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Conserved domains on  [gi|14250567|gb|AAH08737|]
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Solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 [Homo sapiens]

Protein Classification

ADP/ATP carrier family protein( domain architecture ID 1000309)

ADP/ATP carrier family protein may provide transport for nucleotides, amino acids, carboxylic acids, fatty acids, cofactors, or inorganic ions across a membrane; similar to mitochondrial adenine nucleotide carriers

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTZ00169 super family cl36523
ADP/ATP transporter on adenylate translocase; Provisional
 3-298 9.68e-160

ADP/ATP transporter on adenylate translocase; Provisional


The actual alignment was detected with superfamily member PTZ00169:

Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 446.91  E-value: 9.68e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14250567    3 EQAISFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADK--QYKGIVDCIVRIPKEQGVLSFWRGNLANVIR 80
Cdd:PTZ00169   2 DKKTNFATDFLMGGISAAISKTAVAPIERVKMLIQTQDSIPEIKSGKvpRYSGIVNCFRRVSKEQGVLSLWRGNTANVIR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14250567   81 YFPTQALNFAFKDKYKQIFlGGVDKHTQFWRYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKsGTEREFRGLGDC 160
Cdd:PTZ00169  82 YFPTQAFNFAFKDYFKNMF-PKYNQKTDFWKFFGVNILSGGLAGASSLLIVYPLDFARTRLASDIGK-GGDREFTGLFDC 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14250567  161 LVKITKSDGIRGLYQGFSVSVQGIIIYRAAYFGVYDTAKGML-PDPKNTHIVVSWMIAQTVTAVAGVVSYPFDTVRRRMM 239
Cdd:PTZ00169 160 LMKISKQTGFLSLYQGFGVSVQGIIVYRGAYFGLYDSAKALLfGNDKNTNILYKWAVAQTVTILAGLISYPFDTVRRRMM 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 14250567  240 MQSGRK-GADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLRGMGGAFVLVLYDELKKVI 298
Cdd:PTZ00169 240 MMSGRKaKSEIQYTGTLDCWKKILKNEGLGGFFKGAWANVLRGAGGALVLVFYDELQKLL 299
 
Name Accession Description Interval E-value
PTZ00169 PTZ00169
ADP/ATP transporter on adenylate translocase; Provisional
 3-298 9.68e-160

ADP/ATP transporter on adenylate translocase; Provisional


Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 446.91  E-value: 9.68e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14250567    3 EQAISFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADK--QYKGIVDCIVRIPKEQGVLSFWRGNLANVIR 80
Cdd:PTZ00169   2 DKKTNFATDFLMGGISAAISKTAVAPIERVKMLIQTQDSIPEIKSGKvpRYSGIVNCFRRVSKEQGVLSLWRGNTANVIR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14250567   81 YFPTQALNFAFKDKYKQIFlGGVDKHTQFWRYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKsGTEREFRGLGDC 160
Cdd:PTZ00169  82 YFPTQAFNFAFKDYFKNMF-PKYNQKTDFWKFFGVNILSGGLAGASSLLIVYPLDFARTRLASDIGK-GGDREFTGLFDC 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14250567  161 LVKITKSDGIRGLYQGFSVSVQGIIIYRAAYFGVYDTAKGML-PDPKNTHIVVSWMIAQTVTAVAGVVSYPFDTVRRRMM 239
Cdd:PTZ00169 160 LMKISKQTGFLSLYQGFGVSVQGIIVYRGAYFGLYDSAKALLfGNDKNTNILYKWAVAQTVTILAGLISYPFDTVRRRMM 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 14250567  240 MQSGRK-GADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLRGMGGAFVLVLYDELKKVI 298
Cdd:PTZ00169 240 MMSGRKaKSEIQYTGTLDCWKKILKNEGLGGFFKGAWANVLRGAGGALVLVFYDELQKLL 299
Mito_carr pfam00153
Mitochondrial carrier protein;
6-101 3.32e-29

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 106.97  E-value: 3.32e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14250567     6 ISFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQiaadKQYKGIVDCIVRIPKEQGVLSFWRGNLANVIRYFPTQ 85
Cdd:pfam00153   3 LSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGSGK----SKGRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAA 78

                          90
                  ....*....|....*.
gi 14250567    86 ALNFAFKDKYKQIFLG 101
Cdd:pfam00153  79 AIYFGTYETLKRLLLK 94
 
Name Accession Description Interval E-value
PTZ00169 PTZ00169
ADP/ATP transporter on adenylate translocase; Provisional
 3-298 9.68e-160

ADP/ATP transporter on adenylate translocase; Provisional


Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 446.91  E-value: 9.68e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14250567    3 EQAISFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADK--QYKGIVDCIVRIPKEQGVLSFWRGNLANVIR 80
Cdd:PTZ00169   2 DKKTNFATDFLMGGISAAISKTAVAPIERVKMLIQTQDSIPEIKSGKvpRYSGIVNCFRRVSKEQGVLSLWRGNTANVIR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14250567   81 YFPTQALNFAFKDKYKQIFlGGVDKHTQFWRYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKsGTEREFRGLGDC 160
Cdd:PTZ00169  82 YFPTQAFNFAFKDYFKNMF-PKYNQKTDFWKFFGVNILSGGLAGASSLLIVYPLDFARTRLASDIGK-GGDREFTGLFDC 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14250567  161 LVKITKSDGIRGLYQGFSVSVQGIIIYRAAYFGVYDTAKGML-PDPKNTHIVVSWMIAQTVTAVAGVVSYPFDTVRRRMM 239
Cdd:PTZ00169 160 LMKISKQTGFLSLYQGFGVSVQGIIVYRGAYFGLYDSAKALLfGNDKNTNILYKWAVAQTVTILAGLISYPFDTVRRRMM 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 14250567  240 MQSGRK-GADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLRGMGGAFVLVLYDELKKVI 298
Cdd:PTZ00169 240 MMSGRKaKSEIQYTGTLDCWKKILKNEGLGGFFKGAWANVLRGAGGALVLVFYDELQKLL 299
Mito_carr pfam00153
Mitochondrial carrier protein;
6-101 3.32e-29

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 106.97  E-value: 3.32e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14250567     6 ISFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQiaadKQYKGIVDCIVRIPKEQGVLSFWRGNLANVIRYFPTQ 85
Cdd:pfam00153   3 LSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGSGK----SKGRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAA 78

                          90
                  ....*....|....*.
gi 14250567    86 ALNFAFKDKYKQIFLG 101
Cdd:pfam00153  79 AIYFGTYETLKRLLLK 94
Mito_carr pfam00153
Mitochondrial carrier protein;
109-206 2.51e-25

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 96.96  E-value: 2.51e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14250567   109 FWRYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKSGTERefRGLGDCLVKITKSDGIRGLYQGFSVSVQGIIIYR 188
Cdd:pfam00153   1 SELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGSGKSKG--RGILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAA 78

                          90
                  ....*....|....*...
gi 14250567   189 AAYFGVYDTAKGMLPDPK 206
Cdd:pfam00153  79 AIYFGTYETLKRLLLKKL 96
Mito_carr pfam00153
Mitochondrial carrier protein;
209-298 7.78e-18

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 76.93  E-value: 7.78e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14250567   209 HIVVSWMIAQTVTAVAGVVSYPFDTVRRRMMMQSGRKGAdiMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLRGMGGAFV- 287
Cdd:pfam00153   4 SFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGSGKS--KGRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAAAIy 81

                          90
                  ....*....|.
gi 14250567   288 LVLYDELKKVI 298
Cdd:pfam00153  82 FGTYETLKRLL 92
PTZ00168 PTZ00168
mitochondrial carrier protein; Provisional
 116-238 1.34e-03

mitochondrial carrier protein; Provisional


Pssm-ID: 185494 [Multi-domain]  Cd Length: 259  Bit Score: 39.52  E-value: 1.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14250567  116 NLASGGAAGATSLCFVYPLDFARTRLAADVGKSGTErefrglgdclvkitksdgIRGLYQGFSVSVQGIIIYRAAYFGVY 195
Cdd:PTZ00168   6 NLVTGALSGVIVDAVLYPIDSIKTNIQAKKSFSFSD------------------IKKLYSGILPTLVGTVPASAFFYCFY 67

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 14250567  196 DTAKGMLPDpKNTHIVVS--WMIAQTVTAV-AGVVSYPFDTVRRRM 238
Cdd:PTZ00168  68 ELSKKLLTE-YRENISKTnlYLISTSIAEItACIVRLPFEIVKQNM 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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